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Preprint ARTICLE | doi:10.20944/preprints201701.0059.v1

Optimization of Lactoperoxidase and Lactoferrin Separation on an Ion-Exchange Chromatography Step

Naeimeh Faraji, Yan Zhang, Ajay K. Ray

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cation exchange chromatography; minor milk protein; response surface modeling; simulation; steric mass action (SMA); optimization

Online: 12 January 2017 (09:59:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0372.v1

Geodesic structure of generalized Vaidya spacetime through the K-essence

Bivash Majumder, Maxim Khlopov, Saibal Ray, Goutam Manna

Subject: Physical Sciences, Theoretical Physics Keywords: Geodesic structure; Euler-Lagrange equation; K-essence geometry; Vaidya spacetime

Online: 6 November 2023 (16:32:50 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201705.0050.v1

Interconnection between Wheat ABCC13 Transporter and Auxin-Related Genes during Lateral Root Development

Kaushal K. Bhati, Anil Kumar, Ajay Kumar Pandey

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ABCC transporter; lateral roots; Triticum aestivum; auxin; transport inhibition

Online: 8 May 2017 (07:48:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2011.v1

Gamma Ray Pulsars and Opportunities for the MACE Telescope

Atul Pathania, K. K. Singh, Kuldeep Kumar Yadav

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Pulsars; gamma-rays; MACE Telescope

Online: 29 June 2023 (07:23:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0564.v1

A Taxonomy of AI Techniques for Security and Privacy in Cyber-Physical Systems

Ajay Bandi

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Internet of Things (IoT); Beyond 5G; 6G communications; Autonomous systems; Control systems; Real-time systems; Industry 4.0; Aversrial Machine Learning

Online: 10 July 2023 (10:12:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0132.v1

SARS-CoV19-2 Spike Protein Mutation Patterns: A Global Scenario

Renukaradhya K. Math, Mallikarjun Goni, Palaksha K. Javaregowda, Ajay S. Khandagale, AjayKumar Oli

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: coronavirus; spike protein; database; sequence alignment; mutation; homology model; hydrophobic amino acids

Online: 7 July 2020 (16:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0052.v1

Structure of Zn and Na Borophosphate Glasses by X-ray and Neutron Diffraction

Uwe Hoppe, Parker T. Freudenberger, Richard K Brow, Jozef Bednarcik, Alex C. Hannon

Subject: Chemistry And Materials Science, Ceramics And Composites Keywords: borophosphate glasses; short-range order; neutron diffraction; X-ray diffraction

Online: 1 May 2024 (07:15:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0204.v1

Progress and Perspectives of Spectroscopic Studies at Carbon K-edge Using Novel Soft X-ray Pulsed Sources

Zeinab Ebrahimpour, Marcello Coreno, Luca Giannessi, Massimo Ferrario, Augusto Marcelli, Federico Nguyen, Seyed Javad Rezvani, Francesco Stellato, Fabio Villa

Subject: Physical Sciences, Condensed Matter Physics Keywords: Soft X-ray FEL; HHG pulses; time-resolved X-ray spectroscopy; Carbon K-edge; Conical inter-sections; EuPRAXIA@SPARC_LAB

Online: 10 November 2022 (11:47:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0391.v2

Role of Traditional Ethnobotanical Knowledge and Indigenous Communities in Achieving Sustainable Development Goals

Ajay Kumar, Sushil Kumar, Komal Komal, Nirala Ramachiary, Pardeep Singh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Sustainable Development Goals; Ethnobotany; Human Health; Poverty; Traditional Knowledge; Sustainable Agriculture

Online: 20 January 2021 (11:04:41 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0601.v1

Successful Aging and Chronic Osteoarthritis

Ray Marks

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: aging; disability; healthy aging; osteoarthritis; pain, rehabilitation, successful aging

Online: 30 July 2018 (22:20:03 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202107.0633.v1

Biofortification - Associated Costs and Finding Alternatives?

Avik Ray

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Biofortification; Agro-biodiversity; HarvestPlus; Hidden Hunger; Orphan Crops; Wild edibles

Online: 28 July 2021 (16:18:29 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202006.0255.v1

CD44 Alternative Splice Variants v6 and v10

Ahmed Aquib, Ajay Kumar Yadav

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: U87MG; CD44; splice factor

Online: 21 June 2020 (10:45:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1453.v1

Energy and Probability Density Computation for Muonic Hydrogen

Ajay S., Suvrata P. Hegde

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: Muonic hydrogen; energy eigenvalues; probability density distribution; hydrogen spectra; programming

Online: 22 May 2023 (02:42:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0886.v1

The Periodicity of Nuclear Magnetic Moments and Nucleon Binding Energies in Light Nuclides: Implications for Nuclear Structure

Ray Walsh

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: nuclear periodicity; nuclear structure; shell model; nucleon pairing effect; quark structure; representational nuclear chemistry; nucleon binding energy; nuclear magnetic moment

Online: 13 September 2023 (11:13:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0429.v1

Sums and Partial Sums of Horadam Sequences: The Sum Formulas of $\sum_{k=0}^{n}x^{k}W_{k}$ and $ \sum_{k=n}^{n+m}x^{k}W_{k}$ via Generating Functions

Yüksel Soykan

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Horadam numbers; Horadam sequence; sum; partial sum; Fibonacci numbers; Lucas numbers

Online: 27 December 2021 (13:48:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1211.v1

A Closer Look at the Perivascular Unit in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus

Melvin Ray Hayden

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Diabetic cerebral microvascular disease; Enlarged perivascular spaces; Glymphatic system; Neurovascular unit; Perisynaptic astrocyte endfeet; Perivascular astrocyte endfeet; Pervascular spaces; Perivascular unit; Postcapillary venule

Online: 15 December 2023 (18:12:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0437.v1

A Study On Sums of Cubes of Generalized Fibonacci Numbers: Closed Formulas of $\sum_{k=0}^{n}x^{k}W_{k}^{3}$ and $\sum_{k=1}^{n}x^{k}W_{-k}^{3} $

Yüksel Soykan

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Fibonacci numbers; Lucas numbers; Pell numbers; Jacobsthal numbers; sum formulas

Online: 24 April 2020 (10:35:07 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202111.0294.v1

Flexible, Biocompatible PET Sheets: a Platform for Attachment, Proliferation and Differentiation of Eukaryotic Cells

Soumen Samanta, Diana Gaad, Eva Cabet, Alain Lilienbaum, Ajay Singh, Dinesh Kumar Aswal, Mohamed Chehimi

Subject: Chemistry And Materials Science, Biomaterials Keywords: Flexible materials; diazonium salts; surface modification; biocompatible polymers; adhesive; adhesion; eukaryotic cells; muscle fibers

Online: 16 November 2021 (14:36:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0396.v1

Exhaustive Computational Studies on Pyrimidine Derivatives as GPR119 agonist for the Development of Compounds against NIDDM

Priyanshu Nema, Shivangi Agarwal, Shivam Kumar Kori, Ajay Kumar, Varsha Kashaw, Vandana Soni, Arun K Iyer, Sushil Kumar Kashaw

Subject: Biology And Life Sciences, Life Sciences Keywords: Pyrimidine; Homology Modelling; Pharmacophore Mapping; 3D-QSAR; Molecular Docking; ADMET; Drug Design

Online: 9 October 2023 (09:36:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0352.v1

Proteins Nsp12 and 13 of SARS-CoV-2 Have Mitochondrial Recognition Signal: A Connection with Cellular Mitochondrial Dysfunction and Disease Manifestation

Upasana Ray, Feroza Begum

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; ARDS; non-structural proteins; mitochondria

Online: 29 June 2020 (10:40:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0021.v1

Development of Modify Random Waypoint Mobility Model of Routing Protocol for the Mobile Ad-Hoc Network

Ajay Vyas, Margam Suthar

Subject: Engineering, Electrical And Electronic Engineering Keywords: Protocol; Mobile ad hoc network; Mobility Model; Random Waypoint Mobility; throughput.

Online: 4 January 2022 (20:35:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0170.v1

Evaulation of a Model for Urban Vegetation Barriers’ Effects on Air Pollution

Ray F. Nassar

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Air pollution; environmental hazards; Volatile Organic Compounds

Online: 8 January 2021 (16:59:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0190.v1

Na and K Intake from Lunches Served in a Japanese Company Cafeteria and the Estimated Improvement in the Dietary Na/K Ratio Using Low-Na/K Seasonings and Dairy to Prevent Hypertension

Nagako Okuda, Aya Higashiyama, Kozo Tanno, Yuki Yonekura, Makoto Miura, Hiroshi Kuno, Toru Nakajima, Tomomi Nagahata, Hirokazu Taniguchi, Koki Kosami, Kyoko Kojima, Akira Okayama

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: hypertension; nutrition; sodium; potassium; Japanese; company cafeteria; seasoning; dairy

Online: 2 April 2024 (10:37:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0498.v1

Cerebral Microbleeds Associate with Brain Endothelial Cell Activation-Dysfunction and Blood-Brain Barrier Dysfunction-Disruption with an Increased Risk of Hemorrhagic and Ischemic Stroke That Is Capable of Exacerbating Neurodegeneration

Melvin Ray Hayden

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimers Disease; BBB; Cerebral microbleeds; Dementia; Hypertension; MRI; Neurovascular unit; cerebral small vessel disease; Transmission electron microscopy

Online: 8 May 2024 (12:47:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0363.v1

Linking Omics and Gene Editing Tools for Rapid Improvement of Traditional Food Plants for Diversified Foods and Sustainable Food Security

Ajay Kumar, Anju T, Sushil Kumar, Sushil Satish Chhapekar, Sajana Sreedharan, Sonam Singh, Nirala Ramchiary, Su Ryun Choi, Yong Pyo Lim

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Traditional food crops; Climate change; Food security; Omics; Translational genomics; Gene editing

Online: 14 June 2021 (13:02:24 CEST)

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The indigenous communities across the globe especially in the rural areas consume locally available plants known as Traditional Food Plants (TFPs) for their nutritional and health-related needs. Recent research shows that many of the traditional food plants are highly nutritious as they contain health beneficial metabolites, vitamins, mineral elements and other nutrients. Excessive reliance on the mainstream staple crops has its own disadvantages. TFPs are nowadays considered important crops of the future and can act as supplementary foods for the burgeoning global population. They can also act as emergency foods in times of pandemics and other situations like COVID-19. The current situation necessitates locally available alternative nutritious TFPs for sustainable food production. To increase the cultivation or improve the traits in TFPs, it is essential to understand the molecular basis of the genes that regulate some important traits such as nutritional components and resilience to biotic and abiotic stresses. The integrated use of modern omics and gene editing technologies provide great opportunities to better understand the genetic and molecular basis of superior nutrient content, climate-resilient traits and adaptation to local agroclimatic zones. Recently, realising the importance and benefits of TFPs, scientists have shown interest in the prospection and sequencing of traditional food plants for their improvements, further cultivation and mainstreaming. Integrated omics such as genomics, transcriptomics, proteomics, metabolomics and ionomics are successfully used in plants and have provided a comprehensive understanding of gene-protein-metabolite networks. Combined use of omics and editing tools has led to successful editing of beneficial traits in few TFPs. This suggests that there is ample scope of integrated use of modern omics and editing tools/techniques for improvement of TFPs and their use for sustainable food production. In this article, we highlight the importance, scope and progress towards improvement of TFPs for valuable traits by integrated use of omics and gene editing techniques.

Working Paper ARTICLE

A Health SDI: The Benefits of and A Call-to-Action for Building a Global Health SDI

Ajay Gupta, Ramani Peruvemba, Paul A. Churchyard

Subject: Public Health And Healthcare, Other Keywords: Spatial Data Infrastructure; Social Determinants of Health; Healthcare; Health; Geospatial Data Analytics; Geocoding; GeoHealth; GIS; Open Standards; Population Health; Disaster Response; Emergency Response

Online: 23 October 2019 (10:27:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints201706.0078.v1

On-chip High-finesse Fabry-Perot Microcavities for Optical Sensing and Quantum Information

Mohammad H. Bitarafan, Ray G. DeCorby

Subject: Physical Sciences, Optics And Photonics Keywords: Fabry-Perot microcavities; sensing; cavity QED; microcavity lasers

Online: 16 June 2017 (10:38:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0259.v1

Paying Homage to Microvessel Remodeling and Small Vessel Disease in Neurodegeneration: Implications for the Development of Late-Onset Alzheimer’s Disease

Melvin Ray Hayden

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Brain endothelial cells; Blood-brain barrier; Dementia; Late-onset Alzheimer's disease; Microvessel remodeling; Neurodegeneration; Neurovascular unit; Small vessel disease

Online: 3 September 2024 (16:58:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.2015.v1

Antonio Mazzotti, Laura Langone, Simone Ottavio Zielli, Elena Artioli, Alberto Arceri, Lorenzo Brognara, Francesco Traina, Cesare Faldini

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Subtalar arthrorisis; Pediatric; flatfoot; hallux valgus angle; Intermetatarsal angle

Online: 30 April 2024 (15:02:54 CEST)

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Introduction: Subtalar Arthroereisis (STA) is a surgical intervention for pediatric flexible flatfoot (PFF), primarily targeting hindfoot alignment by limiting excessive subtalar eversion. However, its effects on forefoot parameters remain underexplored. This study aims to investigate radiological changes following STA in pediatric patients. Materials and Methods: A retrospective analysis was conducted on consecutive patients treated with STA for PFF. First ray-related angles, including Hallux Valgus Angle (HVA) and Inter-Metatarsal Angle (IMA), alongside hindfoot radiological parameters such as Meary, Calcaneal Pitch, and Costa Bartani angles, were assessed. Subgroup analysis by gender was performed, and correlations between demographic and pre-operative radiological parameters were examined. Results: Forty-one patients (81 feet) with a mean age of 11.6 years were included, with a mean follow-up duration of 6.4 months. No significant differences were observed in first ray-related an-gles pre- and post-operatively, with mean IMA changing from 7.97° to 7.18° and mean HV angles from 9.51° to 8.66°. Noteworthy improvements were seen in flat foot angles, including Meary, Calcaneal Pitch, and Costa Bartani angles, postoperatively. Age subgroup analysis revealed similar trends in IMA and HVA changes between Group A (operated before peak growth) and Group B (operated later). Higher preoperative angles tended to improve, while lower preoperative IMA and HVA tended to worsen postoperatively, all remaining within normal ranges. Conclusion: STA showed positive radiological outcomes for PFF treatment, while negligible changes in first ray-related angles were observed. Age subgroup analysis indicated similar trends regardless of operation timing. Higher preoperative angles tended to improve, while lower preoperative angles tended to worsen postoperatively, despite all falling within non-pathological ranges. Further re-search is warranted to confirm this correlation.

Preprint ARTICLE | doi:10.20944/preprints202305.2066.v1

All-Optical, Air-Coupled Ultrasonic Detection of Low-pressure Gas Leaks and Observation of Jet Tones in the MHz Range

Kyle G. Scheuer, Ray G. DeCorby

Subject: Physical Sciences, Acoustics Keywords: jet tone; leak detection; air-coupled ultrasound; optical ultrasound detection; optomechanics; buckled dome microcavity

Online: 30 May 2023 (07:30:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1671.v1

3D Printed K-band Radar Stealth Lightweight Material with Lotus Leaf Structure

Chuangji Liu, Yingjie Xu, Beiqing Huang, Wan Zhang, Yuxin Wang

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: K-band radar stealth; UV cured polymer composites; 3D printing technology; biomimetic lotus leaf antireflection structure; self-cleaning surface; lightweight material

Online: 23 August 2024 (04:10:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0344.v1

Low-energy Cosmic Rays and Associated MeV Gamma-ray Emissions in the Protoplanetary System

Xulei Sun, Shuying Zheng, Zhaodong Shi, Bing Liu, Ruizhi Yang

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Protoplanetary disk; Low-energy cosmic rays; Gamma rays; Nuclear de-excitation lines

Online: 4 July 2024 (00:18:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0442.v1

UAV-based Survey of Glaciers in Himalayas: Opportunities and Challenges

RAAJ Ramsankaran, P.J. Navinkumar, Ajay Dashora, Anil Kulkarni

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Digital Elevation Models; ortho-mosaicked images; glacier; remote sensing; Unmanned Aerial Vehicle

Online: 28 February 2020 (13:34:22 CET)

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Preprint REVIEW | doi:10.20944/preprints201608.0021.v1

E-waste Management in South Africa: Case Study: Cathode Ray Tubes Recycling Opportunities

Pontsho Ledwaba, Ndabenhle Sosibo

Subject: Environmental And Earth Sciences, Environmental Science Keywords: electrical and electronic waste; recycling; legislative frameworks; environmental management; landfilling

Online: 3 August 2016 (12:33:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0555.v2

An Update on the Chemistry, Pharmacology and Dose Calculations of Mepivacaine Hydrochloride for Podiatrists in the United Kingdom

Ian Reilly, Nicola Burt, Rebecca Reilly, Ajay Swami

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Mepivacaine; Scandonest; local anaesthesia; pharmacology; maximum safe dose; podiatry

Online: 19 January 2021 (10:39:01 CET)

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Preprint TECHNICAL NOTE | doi:10.3390/sci2020030

On Singular Perturbation of Neutron Point Kinetics in the Dynamic Model of a PWR Nuclear Power Plant

Xiangyi Chen, Asok Ray

Subject: Physical Sciences, Applied Physics Keywords: PWR nuclear power plants; point kinetics; singular perturbation

Online: 26 April 2020 (00:00:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0066.v1

Thrombo-inflammation in COVID-19 and Sickle Cell Disease: Two Faces of the Same Coin

Kate Chander Chiang, Ajay Gupta, Prithu Sundd, Lakshmanan Krishnamurti

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Sickle Cell Disease; COVID-19; SARS-CoV-2; Vaso-occlusive Crisis; Pain; Thromboxane; Prostaglandin D2; Thrombo-inflammation; Acute Chest Syndrome; Ramatroban

Online: 5 December 2022 (08:00:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0039.v1

Efficacy and Utilization of Unmanned Aerial System (Uas) as Operational Tools for Disaster Management in India

Kunal Sharma, Rahul Devarani, Ajay Gangwar, Raja Chakrabarty

Subject: Computer Science And Mathematics, Robotics Keywords: Disaster, Operational Strategies, UAV, Drones, Man Made & Natural Disaster, CBRNE

Online: 3 October 2018 (11:08:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0725.v1

Impact of Pre-harvest Fruit Bagging Technology on Growth and Quality Traits in Litchi cv. Rose Scented under Indian Prospective

Satish Chand, Rajat Sharma, Ranjan Srivastava, Ajay Kumar Chandra

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: litchi; fruit bagging; bag colours; dates; quality

Online: 31 August 2020 (16:25:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0374.v2

On Soft Lebesgue Measure

Sujay Goldar, Subhasis Ray

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Soft Set, Soft Element, Soft Real Number, Soft Interval, Soft Sequence, Soft Lebesgue Measure.

Online: 8 December 2022 (07:52:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0115.v1

Internet of Things Aware Secure Dew Computing Architecture for Distributed Hotspot Network: A Conceptual Study

Partha Pratim Ray, Karolj Skala

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Dew computing; Internet of Things; Blockchain; Hotspot Network

Online: 5 August 2022 (03:46:27 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202102.0618.v1

The Concept of Training Image-Based Geostatistics for Spatial Distribution of Hydraulic Conductivity

Fiaz Hussain, Ray-Shyan Wu

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Interpolation; Hydraulic Conductivity; Multi-Point Geostatistics; Training Image

Online: 26 February 2021 (12:47:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0221.v1

Solar Wind Charge-Exchange X-ray Emissions from the O⁵⁺ Ions in the Earth’s Magnetosheath

Zhicheng Zhang, Fei He, Xiao-Xin Zhang, Guiyun Liang, Xueyi Wang, Yong Wei

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: solar wind charge-exchange (SWCX); earth magnetosheath; X-Ray spectrum; interplanetary shock; bow shock; Magnetopause

Online: 2 April 2024 (15:13:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0005.v1

Hydrodynamic Simulation of a Cloudburst Event in Asi Ganga Valley of Indian Himalayan Region Using MIKE11 and Geomatics Techniques

Vasanta Govind Kumar Villuri, Kamal Jain, Ajay Gairola, Srinivas Pasupuleti

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Cloudburst; GIS; MIKE11; DEM; Hydrodynamic model

Online: 1 December 2017 (10:33:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0202.v1

Fish Protein and Lipid Interactions on the Digestibility and Bioavailability of Starch and Protein from Durum Wheat Pasta

Ajay Desai, Margaret Brennan, Xinbo Guo, Xin-An Zeng, Charles Brennan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: pasta; salmon powder; glycaemic index; protein digestibility; polyphenols; antioxidant activity; bioaccessibility

Online: 17 December 2018 (15:59:54 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202007.0193.v1

HnRNPA1 and Its Effect in the Expression of ABCC (ABCC4 and ABCC6) Transporter in Glioma Cell Lines

Tundup Namgail, Dinesh Kumar, Vidhi Vashistha, Ahmed Aquib, Ajay Yadav

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: hnRNPA1; ABCC

Online: 9 July 2020 (12:30:11 CEST)

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Glioblastoma multiforme (GBM) is classified as WHO grade IV Astrocytoma & is the most common highly aggressive form of primary brain tumor. Garde IV tumor are highly recurrent even after treatment, with patient survival rate is less than two years from the time of diagnosis. This might be due to overexpression of one of the factors such as ATP-binding cassette transporters (ABC transporters) responsible for drug resistance. ABCC transporter family a member of ABC transporter was found to mostly responsible for multi drug resistance (MDR) in cancer cells. On the other hand, heterogeneous nuclear ribonucleoprotein (hnRNP's) an alternative splicing factor play different role in various cellular process such as nucleic acid metabolism, transcription and translation regulation, among them hnRNPA1 is best studied and its aberrant deregulation favor development of cancer. This study was focused on to study the function of hnRNPA1 in the expression analysis of ABCC transporter (responsible for MDR) in glioma cell lines. The expression of ABCC transporter (ABCC4 and ABCC6) gene was examined in two glioma cell line i.e. U87MG and T98G in normal and knockdown two alternative variants of hnRNPA1 by Quantitative Realtime PCR and Reverse Transcription PCR. We found that ABCC4 was significantly overexpressed in hnRNPA1 Variant 2 knockdown cells (si hnRNPA1 V2) in U87 (3-fold) and in T98G (18.34-fold), While hnRNPA1 Variant 1 knockdown cells (hnRNPA1 V1i) does not shows any significant effect. Further, the expression of ABCC6 was decreased in both hnRNPA1 V1i (0.40-fold) and hnRNPA1 V2i (0.48-fold) in U87. Reverse transcription-based result was complemented with normal PCR based detection strategy after running in agarose gel for U87MG and T98G glioma cell line. Finally, this result indicates that hnRNPA1 an alternative splicing factor regulate the expression of ABCC4 and ABCC6 transporter which are responsible for multiple drug resistance in cancer. This information will help in future for the development of an alternative method for the treatment of drug resistance cases in brain tumor and other tumors by targeting hnRNPA1 splicing factor.

Preprint ARTICLE | doi:10.20944/preprints202103.0278.v1

Utilization of Mosque as A Part of Early Warning Systems to Reduce Flood Damage in Samarinda City, Indonesia

Riyan Benny Sukmara, Ray Shyan Wu

Subject: Engineering, Civil Engineering Keywords: flooding, early warning, damage, mosque

Online: 10 March 2021 (13:01:45 CET)

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Samarinda City is one of the most attractive cities in Borneo Island (Indonesia) and also as a capital city of EastBorneo Province. The expansion of urban areas becomes essential due to rapid population and housing demand. Base on the statistical report, the annual population growth rate is 0.018% from the year 2016-2017 with a total population of 843446 inhabitants. Many natural disasters occur in some areas in this city, especially flooding. This natural disaster occurs almost every year, many people suffered and forced to evacuate. In 2018 there is 3 flood event with 28311 people was suffered and evacuated, and 5170 houses were flooded [1]. During the flood event, it was very possible to gain damages to their property and make traffic stuck. One common way to reducing the damages is using Early Warning Systems (EWS). Early warning is a major element for disaster risk reduction, including damages. To prevent and mitigate the impact of a disaster, many countries had taken action to build various methods of a public warning system. An effective early warning system focused on people-centered and comprises the following element, such as risk knowledge, technical monitoring and service, communication and dissemination of warnings, and community response capability [2]. Related to the existing condition which Samarinda is a Muslim-dominated city and obviously has a lot of a number of mosques. This is a good potency to develop an early warning system because every mosque has a loudspeaker for echoing Adzan (Muslim prayer-calling). With this existing condition, the loudspeaker can be utilized as a flood outdoor-voice warning announcer. The aim of this study is to briefly introduce the strategy of dissemination early warning by utilizing mosques. The hope of early warning dissemination is giving enough time to the people to evacuate their property to reduce damages and possibly to giving information to avoiding traffic stuck (in a certain location)due to flooding. The results of this study can be used as input for decision-makers to develop effective flood management strategies and policies, especially in the case of an early warning system where not well-developed in Samarinda.

Preprint ARTICLE | doi:10.20944/preprints202305.2216.v1

Impact of Cooperation and Intra-Specific Competition of Prey on the Stability of Prey-Predator Models with Refuge

Soumyadip Pal, Fahad Al Basir, Santanu Ray

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Mathematical modeling; Bifurcation analysis; Global stability; Direction of Hopf bifurcation; Numerical simulations

Online: 31 May 2023 (10:42:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2009.v1

Characterization of Na_0.5Bi_0.5TiO₃ Single Crystals by X-ray Diffraction, Scanning Electron Microscopy, X-ray Photoelectron Spectroscopy, Optical Absorption, Electric and Thermoelectric Properties Studies

Jan J.Suchanicz, Kamila Kluczewska-Chmielarz, Grzegorz Jagło, Andrzej Kruk, Antoni Kania, Dorota Sitko, Michalina Nowakowska-Malczyk, Marcin Łapiński, Grzegorz Stachowski, Tatiana Kruzina

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Na_0.5Bi_0.5TiO₃ single crystals; insulator-metal transition; electrical conductivities; relaxation process

Online: 30 May 2024 (10:42:39 CEST)

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High-quality and large-size single crystals of lead-free Na0.5Bi0.5TiO3 were grown using the Czo-chralski technique. The crystals had pure perovskite structure with rhombohedral symmetry and were translucent in the visible and near infrared spectral ranges recorded in the interval 350-1050 nm. The energy gaps determined from the X-ray photoelectron spectroscopy (XPS) and optical measurements were approximately 2.92 eV. The current-voltage characteristics, depolarization current, dc (σdc) and ac (σac) electrical conductivity, and Seebeck coefficient of the crystals were investigated. The frequency/temperature-dependent electrical properties were also measured and analyzed through complex impedance spectroscopy. An overlapping reversible insulator-metal transition (resistive switching) on nanoscales, caused by the electric field, was detected. This was the first time that most of these investigations were performed for this material. The following conductivity mechanisms of NBT single crystals were identified: (i) quasi-free electron and hole conduction and hopping-charges mechanism at low temperatures, (ii) small polaron conductivity in the middle temperature range, and (iii) a significant contribution of the oxygen vacancies to conductivity in the high temperature range. The activation energy values determined from the conductivity data, the imaginary part of the electric impedance and the modulus indicate that the relaxation process in the high-temperature range is attributable to both single and double ionized oxygen vacancies, in combination with the hopping of electrons between Ti4+ and Ti3+. P-type electrical conductivity was also found. These discoveries create new possibilities of reducing the electrical conductivity of NBT and improving the process of effectively poling this material. The density of the electronic states was investigated using an ab initio method. The energy gap cal-culated for NBT (R3c) was 2.8 eV, and is well comparable to those determined from XPS and optical measurements. Our results indicate the possibility of tuning material properties by inten-tionally creating non-stoichiometry/structural defects (oxygen vacancies, cation excess and cation deficiency).

Preprint ARTICLE | doi:10.20944/preprints201703.0016.v1

A 14-bit Hybrid Incremental Sigma-Delta/Cyclic ADC for X-ray Linear Array Sensor

Yuze Niu, Yacong Zhang, Zhuo Zhang, Miaomiao Fan, Wengao Lu, Zhongjian Chen

Subject: Engineering, Electrical And Electronic Engineering Keywords: hybrid ADC; sigma-delta ADC; cyclic ADC; pseudo-differential OTA; X-ray sensor

Online: 2 March 2017 (08:37:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.1367.v1

Beyond Anticoagulation: A Comprehensive Review of Non-Vitamin K Oral Anticoagulants (NOACs) in Inflammation and Protease-Activated Receptor Signaling

Shirin Jannati, Rajashree Patnaik, Yajnavalka Banerjee

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: NOAC; Anti-Inflammation; Protease-Activated-Receptor Signaling; Factor Xa; Thrombin.

Online: 20 June 2024 (00:16:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0862.v1

Enabling Low-Dose In Vivo Benchtop X-ray Fluorescence Computed Tomography through Deep Learning-Based Denoising

Naghmeh Mahmoodian, Mohammad Rezapourian, Asim Abdulsamad Inamdar, Kunal Kumar, Melanie Fachet, Christoph Hoeschen

Subject: Engineering, Bioengineering Keywords: Deep learning; Artificial Intelligence; Xray Fluorescence; XFCT; AI; DL

Online: 14 March 2024 (12:26:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0377.v1

Magnetic Field Perturbations to a Soft X-Ray Activated Fe (II) Molecular Spin State Transition

Guanhua Hao, Alpha T. N'Diaye, Thilini K. Ekanayaka, Ashley S. Dale, Xuanyuan Jiang, Esha Mishra, Corbyn Mellinger, Saeed Yazdani, John W. Freeland, Jian Zhang, Ruihua Cheng, Xiaoshan Xu, Peter A. Dowben

Subject: Physical Sciences, Condensed Matter Physics Keywords: Spin crossover; Fe(II); activation barriers; X-ray excitation; magnetic field effects; [Fe{H2B(pz)2}2(bipy)]; molecular multiferroic.

Online: 18 August 2021 (11:30:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0020.v1

Some Integral Transforms of the Generalized k-Mittag-Leffler Function

Feng Qi, Kottakkaran Sooppy Nisar

Subject: Computer Science And Mathematics, Analysis Keywords: integral transform; generalized k-Mittag-Leer function; generalized Wright function; generalized k-Wright function; gamma function

Online: 8 October 2016 (10:41:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0133.v1

Tangles with k Ropes and 2k Hands

Aashna Hari, Emma Li, Rachel Liu

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: tangles; isomorphism; analogs of groups; matrices; group presentation

Online: 4 December 2023 (04:16:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0433.v1

Astrosat SXT X-ray Spectrum Changes over the 35-Day Cycle in Hercules X-1

Denis Leahy, Riddhiman Sharma

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: binaries; eclipsing — star; neutron— stars; individual (HZ Her/ Her X-1)

Online: 7 June 2024 (08:00:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0003.v2

Overexpression of a Membrane Transport System MSMEG_1381 and MSMEG_1382 Confers Multidrug Resistance in Mycobacterium smegmatis

Salini S., Balaji Muralikrishnan, Sinchana Bhat, Sudeep Ghate, Shyama Prasad Rao, R. Ajay Kumar, Krishna Kurthkoti

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Drug resistance; Efflux pump; TetR transcriptional regulator; Mycobacteria; MmpL

Online: 24 May 2022 (11:32:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0057.v1

Hijacking the Host Immune Cells by Dengue Virus: Molecular Interplay of Receptors and Dengue Virus Envelope

Feroza Begum, Sandeepan Das, Debica Mukherjee, Upasana Ray

Subject: Biology And Life Sciences, Virology Keywords: DENV; tropism; receptors; entry; immune cells

Online: 5 August 2019 (08:14:40 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202007.0174.v2

Cracking the Secret Code of the Selectivity Ratio Between K⁺ and Na⁺ Ions in the KcsA K⁺ Channel

Yongwoon Jung, Sangyong Nam

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: KcsA K+ channel; K+ ion and N+ ion; Selectivity Filter; Snug-fit Mechanism; Selectivity Ratio; Brownian Dynamics

Online: 3 August 2020 (04:57:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0847.v1

MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic Potential

Junjiang Fu, Saber Imani, Mei-Yi Wu, Ray-Chang Wu

Subject: Biology And Life Sciences, Life Sciences Keywords: microRNA; miR‐34; tumor suppressor; miRNA therapy

Online: 10 August 2023 (10:53:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0052.v1

A Study of McVittie Spacetime in Stationary and Dynamical Regime

Indranath Bhattacharyya, Saibal Ray, Riju Nag, Samudra Sundar Nag

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Einstein equations; McVittie solution; black hole; dark energy; embedded spacetime

Online: 6 June 2022 (03:17:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0766.v1

The Importance of Vitamin K and the Vitamins K and D Combined for the Calcium Metabolism and Bone Health: A Review

Jan O. Aaseth, Trine Elisabeth Finnes, Merete Askim, Jan Alexander

Subject: Public Health And Healthcare, Health Policy And Services Keywords: vitamin K; osteocalcin; matrix Gla protein; osteoporosis; vascular calcification; bone loss

Online: 12 June 2024 (14:41:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0587.v1

Women of Color in the Health Professions: A Scoping Review of the Literature

Olihe Okoro, Omolayo Umaru, Meghana Ray

Subject: Social Sciences, Gender And Sexuality Studies Keywords: Intersectionality; Healthcare professions; Women of color; Pharmacy; Racial/Ethnic inequity; Gender inequity; Discrimination; Professional advancement; Underrepresentation

Online: 9 November 2023 (07:29:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0351.v1

BCG Vaccination Strategy for Preventaion against COVID-19: Hype or Hope?

Keshav Rajarshi, Aroni Chatterjee, Shashikant Ray

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; BCG immunization; SARS-CoV-2; immunity and tuberculosis

Online: 19 April 2020 (13:55:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0974.v1

Role of Artificial Intelligence in Autonomous Vehicles

Ajay Atmaram Waghmare, Subramaniam GANESAN, Jingshu Chen

Subject: Engineering, Automotive Engineering Keywords: Autonomous vehicles (AVs); Artificial intelligence (AI); Perception algorithms; Decision-making systems; Control mechanisms; Explainable AI; Federated learning; Reinforcement learning; Deep neural net

Online: 14 August 2024 (07:09:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0644.v1

Healthcare Policies to Eliminate Neglected Tropical Diseases (NTDs) in India: A Roadmap

Ajay Chandra, S D Sreeganga, Nibedita Rath, Arkalgud Ramaprasad

Subject: Public Health And Healthcare, Health Policy And Services Keywords: neglected diseases; healthcare policy; India; ontology; framework; roadmap

Online: 8 August 2023 (08:55:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.2038.v1

Harnessing Mechanical Forces for Cancer Treatment

Alka Kumari, S. Manasa Veena, Rashmita Luha, Ajay Tijore

Subject: Biology And Life Sciences, Life Sciences Keywords: mechanical force; apoptosis; tumor; tumor microenvironment; mechanomedicine

Online: 31 July 2023 (11:36:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0061.v1

Coastal Upwelling in the Bay of Bengal: Role of Local and Remote Windstress

Sthitapragya Ray, Debadatta Swain, M. M. Ali, Mark A. Bourassa

Subject: Environmental And Earth Sciences, Oceanography Keywords: Coastal upwelling; Upwelling index; Scatterometer; Wind stress; Kelvin Wave; Ekman Transport

Online: 5 July 2022 (05:36:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0914.v1

Dependence of Cucumber Productivity and Nutrient Uptake on the Composition of the Growing Media and Nitrogen Fertilization

Rita Čepulienė, Lina Marija Butkevičienė, Vaida Steponavičienė

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: wood fiber; cucumber productivity; nutrient uptake; physicochemical properties of growing media

Online: 11 July 2024 (04:52:38 CEST)

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:Peat substrate is made from peat from drained peatlands, which is a limited resource. A realistic estimate is that 50% of the world’s wetlands have been lost. Peat is used in horticulture, especially for the cultivation of vegetables in greenhouses. The consequences of peatland exploitation are an in-crease in the greenhouse effect and a decrease in carbon stocks. Wood fiber can be used as an al-ternative to peat. The chemical properties of the growing media interact and change continuously due to the small volume of the growing media, which is limited by the growing container. This study aims to gain new knowledge on the impact of nutrient changes in the microbial degradation of carbon compounds in wood fiber and mixtures with peat substrate on the content and uptake of nutrients required by plants. Cucumbers (Cucumis sativus L.) variety “Dirigent H” developed in the Netherlands, were cultivated in growing media of peat substrate and wood fiber: (1) peat substrate (PS); (2) wood fiber (WF); (3) wood fiber and peat substrate 50/50 v/v (WF/PS 50/50); (4) wood fiber and peat substrate 25/75 v/v (WF/PS 25/75). The rates of fertilization were the following: (1) con-ventional fertilization (CF); (2) N13; (3) N23; (4) N30. The experiment was carried out in three repli-cations. As the amount of wood fiber increased, the humidity and pH of the growing medium in-creased. Fertilization of cucumbers with different rates of nitrogen influenced the nutrient uptake. Plants grown in 50/50 and 25/75 growing media had the best Cu uptake when fertilized with N23. When the plants grown in the wood fiber media and the 50/50 media were fertilized with N13, N23, and N30, the Mn content in the growing media at the end of the growing season was significantly lower than the Mn content in the media with conventional fertilization. Thus, nitrogen improved the uptake of Mn by plants grown not only in the wood fiber but also in combinations with peat sub-strate. Growing plants in wood fiber and fertilizing them with N13 can result in optimum uptake of micronutrients. The number and mass of cucumber fruits per plant were influenced by the amount of wood fiber in the growing media and the application of nitrogen fertilizer. The highest number of fruits and mass of fruits per plant was obtained significantly higher when cucumbers were grown on WF/PS 50/50 growing media with additional N13 fertilization.

Preprint ARTICLE | doi:10.20944/preprints202405.0471.v1

Nutrient Use Efficiency and Cucumber Productivity as a Function of Nitrogen Fertilization Rate and Wood Fiber Content in the Growing Media

Rita Čepulienė, Lina Marija Butkevičienė, Vaida Steponavičienė

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: nutrient uptake; cucumber productivity; wood fiber; physicochemical properties of growing media

Online: 8 May 2024 (08:54:07 CEST)

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: Greenhouse plants are usually grown in containers filled with growing media. Peat is the main component of the growing media used in greenhouses. However, peat substrate is made from peat from drained peatlands, which is a limited resource. Wood fiber can be an alternative to use as a growing media for controlled-climate crops. The chemical properties of the growing media interact and change continuously due to the small volume of the growing media, which is limited by the vegetative container. Therefore, this study aims to gain new knowledge on the impact of nutrient changes in the microbial degradation of carbon compounds in wood fiber and mixtures with peat substrate on the content and uptake of nutrients required by plants. Cucumbers (Cucumis sativus L.) were cultivated in growing media of peat substrate and wood fiber: (1) peat substrate (PS); (2) wood fiber (WF); (3) wood fiber and peat substrate 50/50 v/v (WF/PS 50/50); (4) wood fiber and peat substrate 25/75 v/v (WF/PS 25/75). The rates of fertilization were the following: (1) conventional fertilization (CF); (2) N13; (3) N23; (4) N30. Fertilization of cucumbers with different rates of nitrogen influenced the nutrient uptake. Plants grown in WF/PS 50/50 and WF/PS 25/75 growing media had the best Cu uptake when fertilized with N23. When the plants grown in the wood fiber media and the 50/50 media were fertilized with N13, N23, and N30, the Mn content in the growing media at the end of the growing season was significantly lower than the Mn content in the media with conventional fertilization. Thus, nitrogen improved the uptake of Mn by plants grown not only in the wood fiber but also in combinations with peat substrate. Growing plants in wood fiber and fertilizing them with N13 can result in optimum uptake of micronutrients. The number and mass of cucumber fruits per plant were influenced by the amount of wood fiber in the growing media and the application of nitrogen fertilizer. The highest number of fruits and mass of fruits per plant was obtained significantly higher when cucumbers were grown on WF/PS 50/50 growing media with additional N13 fertilization.

Preprint ARTICLE | doi:10.20944/preprints201711.0147.v1

A Comparative Analysis of the Proteins and Lipids in Breast, Leg, and Thigh Meats of a Commercial Domesticated Turkey

W. Keith Ray, Sherry B. Hildreth, Judith M. Jervis, Richard F. Helm

Subject: Biology And Life Sciences, Food Science And Technology Keywords: glycolysis; lipidome; meat; mitochondria; oxidation; proteome; turkey

Online: 23 November 2017 (03:11:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0038.v1

Coastal Upwelling in the western Bay of Bengal: Role of Local and Remote Windstress

Sthitapragya Ray, Debadatta Swain, M. M. Ali, Mark A. Bourassa

Subject: Environmental And Earth Sciences, Oceanography Keywords: Coastal upwelling; Upwelling index; Scatterometer; Wind stress; Kelvin Wave; Ekman Transport

Online: 2 September 2022 (09:57:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0106.v1

Characterization of Osteoarthritis in a Medial Meniscectomy-Induced Animal Model Using Contrast-Enhanced X-Ray Microtomography

Takehito Sugasawa, Tomoaki Kuji, Kai Aoki, Koki Yanazawa, Akiko Takenouchi, Makoto Watanabe, Yoshiya Tome, Yoshinori Takeuchi, Yuichi Aita, Naoya Yahagi, Yasuhiro Shishikura, Seikou Ono, Yasuko Yoshida, Yasushi Kawamai, Kazuhiro Takekoshi

Subject: Biology And Life Sciences, Biophysics Keywords: osteoarthritis; synovitis; articular cartilage; microfocus X-ray CT; 3D analysis

Online: 9 February 2020 (15:49:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1134.v1

Investigating Genetic Diversity and Population Structure in Rice Breeding from Association Mapping of 116 Accessions Using 64 Polymorphic SSR Markers

Alok kumar Singh, Devendra Kumar, Donato Gemmati, Ranjith Kumar Ellur, Ashutosh Singh, Veronica Tisato, D.K. Dwivedi, Sanjay Kumar Singh, Kishor Kumar Sadasivuni, Nawaz Ahmad Khan, Ajay Vikram Singh

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Rice; Population structure; Genetic diversity; PIC; Association mapping; Variability

Online: 20 March 2024 (04:45:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0281.v2

Mutation Hot Spots in Spike Protein of SARS-CoV-2 Virus

Feroza Begum, Arup Kumar Banerjee, Upasana Ray

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; S protein; RBD; S1; S2

Online: 7 September 2020 (04:15:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0068.v1

Researcher Conduct Determines Data Reliability

Mark N. Wass, Larry Ray, Martin Michaelis

Subject: Social Sciences, Behavior Sciences Keywords: reproducibility crisis; replication crisis; data reliability; bias; publication bias; meta-research

Online: 5 April 2018 (10:54:09 CEST)

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Working Paper ARTICLE

k-Means+++: Outliers-Resistant Clustering

Adiel Statman, Liat Rozenberg, Dan Feldman

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Clustering; Approximation; Outliers

Online: 19 November 2020 (10:54:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1501.v1

X-ray Microtomography Analysis of Integrated Crop-Livestock Production Impact on Soil Pore Architecture

José V. Gaspareto, Luiz Fernando Pires

Subject: Environmental And Earth Sciences, Soil Science Keywords: Computed tomography; Image analysis; Minimum tillage; No-tillage; Soil structure; Soil management; Soil porous structure

Online: 23 May 2024 (07:35:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0064.v1

Identification of Secondary Phases in Cu₂ZnSnS₄ Layers by In-depth Resolved X-ray Photoelectron Spectroscopy Analysis

Xianfeng Zhang, M. Kobayashi

Subject: Chemistry And Materials Science, Other Keywords: secondary phases; CZTS film; XPS

Online: 12 January 2017 (11:04:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0136.v1

Nonsingular phantom cosmology in Five Dimensional f(R,T) Gravity

Rakesh Ranjan Sahoo, Kamal Lochan Mahanta, Saibal Ray

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Phantom energy; LRS Bianchi type-I; $f(R,T)$ theory; $5d$ spacetimes

Online: 8 August 2022 (08:11:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0524.v1

Flood Management in Samarinda, Indonesia: Recent Progress

Riyan Benny Sukmara, Ray Shyan Wu, Ariyaningsih Ariyaningsih

Subject: Engineering, Automotive Engineering Keywords: urban flooding; flood management; flood disaster; Samarinda;

Online: 23 February 2021 (15:46:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0388.v1

On the Use of Pharmacies to Establish a Defibrillator Network: A Data Driven Case Study for the Area of the Peloponnese

Manolis Wallace, Christos Champilomatis, Panagiota Ventirozou, Georgios Pappas, Vassilis Poulopoulos, Costas Vassilakis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Defibrillator network; pharmacies; population coverage.

Online: 4 July 2024 (05:57:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0153.v1

Cosmic-Ray Extremely Distributed Observatory: Status and Perspectives

Dariusz Gora

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: Cosmic-rays; Citizien Science; Extensive air showers

Online: 8 October 2018 (15:45:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0195.v1

Digital Miniature Cathode Ray Magnetometer

Marcos Turqueti, Gustav Wagner, Azriel Goldschmidt, Rebecca Carney

Subject: Engineering, Electrical And Electronic Engineering Keywords: Magnetometer; Magnetic Probe; Imager; Cathode Ray; Undulator; DSP; CMOS sensor; Cryo-genic; Cold Electronics; Magnetoencephalography

Online: 4 January 2024 (03:38:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0227.v1

On the Ray-Wavefront Duality

Antonio Diaz-Cano, Francisco Gonzalez-Gascon, Luis Sanchez-Soto

Subject: Physical Sciences, Optics And Photonics Keywords: geometrical optics; ray equation; eikonal equation; wavefronts

Online: 18 February 2022 (09:02:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0298.v2

Cosmic Ray Extremely Distributed Observatory

Piotr Homola, Dmitriy Beznosko, Gopal Bhatta, Łukasz Bibrzycki, Łukasz Bratek, Michalina Borczyńska, Nikolay M. Budnev, Dariusz Burakowski, David Edwin Alvarez-Castillo, Kevin Almeida Cheminant, Aleksander Ćwikła, Punsiri Dam-o, Niraj Dhital, Alan Duffy, Piotr Głownia, Krzysztof Gorzkiewicz, Dariusz Góra, Alok C. Gupta, Zuzana Hlávková, Martin Homola, Joanna Jałocha, Robert Kamiński, Michał Karbowiak, Marcin Kasztelan, Renata Kierepko, Marek Knap, Péter Kovács, Szymon Kuliński, Bartosz Łozowski, Marek Magryś, Mikhail V. Medvedev, Justyna Mędrala, Jerzy W. Mietelski, Justyna Miszczyk, Alona Mozgova, Antonio Napolitano, Vahab Nazari, Y. Jack Ng, Michał Niedźwiecki, Cristina Oancea, Bogusław Ogan, Gabriela Opiła, Krzysztof Oziomek, Maciej Pawlik, Marcin Piekarczyk, Bożena Poncyljusz, Jerzy Pryga, Matías Rosas, Krzysztof Rzecki, Jilberto Zamora-Saa, Katarzyna Smelcerz, Karel Smolek, Weronika Stanek, Jarosław Stasielak, Slawomir Stuglik, Jolanta Sulma, Oleksandr Sushchov, Manana Svanidze, Kyle Tam, Arman Tursunov, José-M. Vaquero, Tadeusz Wibig, Krzysztof W. Woźniak

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: cosmic rays; cosmic ray ensembles; extensive air showers; large scale cosmic ray correlations; CREDO Collaboration

Online: 15 October 2020 (16:13:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0089.v1

Scale-Dependent Light Scattering Analysis of Textured Structures on LED Light Extraction Enhancement Using Hybrid Full-Wave Finite-Difference Time-Domain and Ray-Tracing Methods

Tsung-Xian Lee, Ching-Chia Chou

Subject: Physical Sciences, Optics And Photonics Keywords: Light-emitting diodes; Light extraction efficiency; Textured structures; Light scattering; BSDF, BRDF, and BTDF

Online: 15 March 2017 (00:12:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0364.v1

K-Ras Binds Calmodulin-Related centrin1 With Potential Implications for K-Ras Driven Cancer Cell Stemness

Ganesh babu Manoharan, Christina Laurini, Sara Bottone, Nesrine Ben Fredj, Daniel Kwaku Abankwa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: K-Ras; centrin; calmodulin; mitosis; centrosome; BRET

Online: 5 May 2023 (11:41:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0113.v1

Vehicle PEPS System with Intelligent Internet of Things

Ray-I Chang, Tzu-Chieh Lin, Jeng-Wei Lin

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Passive Entry Passive Start; Smart Watch; Electrocardiogram; Long Short-Term Memory; Auto Encoder; Collective Decision

Online: 4 December 2023 (04:26:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0995.v1

Rationale and Protocol of ETERNITY-ITA Study: Use of Etelcalcetide for Preserving Vitamin K-Dependent Protein Activity Italian Study

Maria Fusaro, Andrea Aghi, Carmela Marino, Francesca Mallamaci, Mario Plebani, Martina Zaninotto, Maria Grano, Silvia Concetta Colucci, Maurizio Gallieni, Thomas L. Nickolas, Sandro Giannini, Stefania Sella, Paolo Simioni, Alberto Bazzocchi, Giuseppe Guglielmi, Fulvia Taddei, Enrico Schileo, Maria Carmela Versace, Giovanni Luigi Tripepi

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Bone fractures; Etecalcetide; Hemodialysis; Vascular calcification; Vitamin K.

Online: 14 August 2024 (07:14:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1553.v1

Anti-Cancer and Anti-Diabetics Potentials of Punicalagin Derivatives Extracted from Peeled of Pomegranate (Punica granatum)

Sabina Yasmin, Ajay Kumar Yadav, Rosolonjatovo Heriniavo Michael, Shabana Khatun, Sarthak Chauhan, Manoj Kurmi, Simranjit Kaur, Nazima Haider, Ajay Kumar Sah, Akash Kumar, Sumeet Gupta, Pritam Singh, Kavita Munjal, Mohammad Yousuf Ansari

Subject: Medicine And Pharmacology, Pharmacy Keywords: Punicalagin; hepatoprotective; polyphenols

Online: 22 August 2023 (10:10:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0051.v3

Quantum and Quantum-Inspired Stereographic K Nearest-Neighbour Clustering

Ark Kumar Modi, Alonso Viladomat Jasso, Roberto Ferrara, Janis Noetzel, Christian Deppe, Maximilian Schädler, Fred Fung

Subject: Physical Sciences, Quantum Science And Technology Keywords: Quantum K-Means; Quantum Machine Learning; Quantum Computing; K-Means Clustering; 6G Communication; Quadrature Amplitude Modulation; Quantum-Classical Hybrid Algorithms; Quantum-Inspired Algorithms

Online: 19 September 2023 (04:33:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0049.v1

Vitamin K and the Visual System: A Narrative Review

Michael A. Mong

Subject: Medicine And Pharmacology, Ophthalmology Keywords: vitamin K; vitamin K1; vitamin K2; eye; visual function; cognitive function; vitamin K-dependent protein; matrix Gla protein; ferroptosis

Online: 3 February 2023 (01:15:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0140.v1

A Comparison of K-Means and Mean Shift Algorithms

Mehak Nigar Shumaila

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: K-Mean, Mean-Shift, Performance, Accuracy

Online: 5 August 2021 (11:00:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0179.v1

Growth Curve Models and Clustering Techniques for the Study of New Sugarcane Hybrids: An Integrated Approach with K-Means, K-Medoids, and DBSCAN

Carlos David Carretillo Moctezuma, María Guzmán Martínez, Flaviano Godínez Jaimes, José Concepción García Preciado, Ramón Reyes Carreto, José Torrones Salgado, Edgar Pérez Arriaga

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Growth curves; clustering; varieties; sucrose percentage

Online: 3 September 2024 (10:59:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1221.v1

Anisotropic Fractional Cosmology: K-Essence Theory

J. Socorro, J Juan Rosales, L Toledo Sesma

Subject: Physical Sciences, Mathematical Physics Keywords: Fractional derivative; Fractional Quantum Cosmology; K-essence formalism; Classical and Quantum exact solutions

Online: 19 September 2023 (15:23:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0101.v1

On Generalized k-Fractional Derivative Operator

Gauhar Rahman, Kottakkaran Sooppy Nisar, Shahid Mubeen

Subject: Computer Science And Mathematics, Analysis Keywords: beta function; k-beta function; hypergeometric function; k-hypergeometric function; Mellin transform; fractional derivative; Appell's function; k-Mittag-Leffler function

Online: 15 December 2017 (06:44:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.2125.v1

Homing and Engraftment of Hematopoietic Stem Cells Following Transplantation: A Pre-clinical Perspective

Tanvir Hasan, Ajay Ratan Pasala, Dhuha Hassan, Justine Hanotaux, David S Allan, Harinad B Maganti

Subject: Medicine And Pharmacology, Transplantation Keywords: Hematopoietic stem cell transplantation; xeno-transplantation; homing; engraftment; clonal hematopoiesis; clonal leukemogenesis; competitive repopulation.

Online: 27 December 2023 (13:57:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0313.v3

Small-Object Detection in Remote Sensing Images with End-to-End Edge-Enhanced GAN and Object Detector Network

Jakaria Rabbi, Nilanjan Ray, Matthias Schubert, Subir Chowdhury, Dennis Chao

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: object detection; faster region-based convolutional neural network (FRCNN); single-shot multibox detector (SSD); super-resolution; remote sensing imagery; edge enhancement; satellites

Online: 29 April 2020 (13:33:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1623.v2

Methodologies Toward Optimization of Y₂O₃:Eu@SiO₂ Nanoparticles as Photosensitizers for X-Ray Activated Photodynamic Therapy (XPDT) of Cancer

Hannah J. Zhang, Tristan Ide, Maharajan Sivasubramanian, Lara Leoni, Jeffrey S. Souris, Divya Brahmbhatt, Eve Tanios, Ariel Pan, Shih-Hsun Cheng, Nai-Tzu Chen, Leu-Wei Lo, Chin-Tu Chen

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Cancer; Y₂O₃:Eu@SiO₂Nanoparticles; Photodynamic Therapy; Photosensitizer ; ;

Online: 23 July 2024 (09:47:03 CEST)

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Traditional photodynamic therapy (PDT) is often limited in its efficacy by insufficient light penetration, inefficient photosensitizer energy transfer, and inadequate target tissue oxygenation. X-ray activated PDT (XPDT), using nanoparticle (NPs) photosensitizers comprised of europium-doped yttrium oxide cores encased within silica shells (Y₂O₃:Eu@SiO₂), offers the potential of overcoming most of these limitations. Aimed at maximizing the generation of reactive oxygen species (ROS), this study reports methodologies for investigation of the effects of synthesis conditions on the characteristics of Y₂O₃:Eu@SiO₂NP. Transmission electronic microscope (TEM) revealed that the NP core diameter was linearly, positively correlated with condensation time (R2 = 0.7357, p < 0.05) and linearly, negatively correlated with urea concentration (R2 = 0.958, p < 0.05). The addition of cetyltrimethylammonium bromide (CTAB) during core synthesis demonstrated enhanced particle dispersion. Silica coating via APTES-1 and TEOS-3 conditions resulted in Y₂O₃:Eu@SiO₂ NPs that generated the highest ROS, with 8.7-fold and 8.9-fold increase respectively in relative fluorescence intensity at 8 Gy irradiation compared to a 5.2-fold increase in PBS under the same condition. In vivo evaluation using 18F-fluorothymidine positron emission tomography (18F-FLT PET) of mouse xenografts of a human prototypical cancer (ovarian) revealed a 55% reduction in tumor proliferation of radiation-sensitive CAOV3 tumors treated with Y₂O₃:Eu@SiO₂ NPs compared to a 19% reduction in tumor proliferation of radiation-resistant SKOV3 tumors on the fourth day post-treatment. Taken together, these findings suggest Y₂O₃:Eu@SiO₂ NPs can serve as effective photosensitizers for XPDT and their performance characteristics can be optimized by selecting synthesis conditions and parameters to deliver the desirable therapeutic effects, offering novel approaches to circumventing many of the limitations of conventional PDT in the treatment of cancer.

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