Formaldehyde, sulfuric acid and salicylic acid were combined to create 3,3’-methylenebis[2-hydroxybenzoic acid] (MHB) ligand, which was subsequently permitted to bind with zinc ions. The ligand and its zinc (II) complex (Zn-MHB) have been described by a combination of elemental analyses, spectral (UV-Vis, IR, MS, NMR), XRD, TEM as well as TGA measurement. The ligand has been suggested to coordinate to the zinc center in tetradentate manner forming binuclear tetrahedral complex. An X-ray analysis indicated a considerable difference between MHB (crystalline) and Zn-MHB (amorphous). UV-Vis spectra were used to determine the optical properties such as bandgap, refractive index, optical conductivity and penetration depth. Possibility of employing the samples for optoelectronic applications was indicated from the band gap values which underlie the range of semiconductors. TEM revealed spherical shapes and mutation of ligand particles into nano-scale by complexation. The antimicrobial potential of the MHB towards gram-positive and negative bacterial growths has been investigated. The results suggested that it would be possible to employ MHB to stop bacterial development, particularly salmonella typhimurium. Cytotoxicity of the MHB was assessed against two types of mammalian cells: VERO (the kidney of an African green monkey) and HFB4 (human skin melanocytes). Lower sensitivity was observed in VERO cells.

There are overwhelming empirical evidences highlighting the contribution of indiscriminate antibiotic usage (ABU) in food animals to the overall burden of antibiotic resistance (ABR) in humans, thus making antibiotic use the main selective pressure driving antibiotic resistance. Social and behavioral perspective on antibiotic use and resistance in poultry is limited. Our study therefore aimed at obtaining information on antibiotic usage, awareness of ABR, and the attitude and perceptions towards prudent antibiotic usage and ABR. A cross-sectional survey using a structured questionnaire was conducted in 125 poultry farms in Kwara state in December 2019. Most farmers (69.6%, n=87/125) were aware of ABR and had satisfactory knowledge about ABR with a mean knowledge score of 3.16±1.47. The age, gender, level of education of farmers, and their flock size were significantly associated with a satisfactory knowledge of ABR (p<0.05). Tertiary education was significantly associated with ABR awareness (OR: 4.7; 95% CI: 0.0690, 0.654; p=0.007) and the ABR knowledge level (OR: 7.8269; 95% CI: 3.2693, 18.7381; p < 0.01). Higher flock size was significantly associated with a satisfactory knowledge of ABR (OR: 9.4551; 95%CI: 3.7928, 23.5707; p<0.01). Most of the poultry farmers (68%) had positive attitudes towards prudent antibiotic use with a mean score of 2.75±0.89. On the contrary, only 32.8% of poultry farmers had a good perception of ABR with a mean perception score of 4.95±1.12. The ABR knowledge level was significantly associated with the perceptions of farmers (p<0.05) but not their attitudes toward ABU and ABR (P=0.083). There was evidence of unprescribed use of antibiotics in poultry and a failure to observe antibiotic withdrawal periods. These constitute a risk of exposure to unacceptable levels of drug residues from poultry products and an increased risk of ABR. Improving education and communication on antibiotic stewardship programs are crucial to prevent the looming antibiotic apocalypse.

This preliminary study introduces the incorporation and chemical stabilization of sulfur waste into geopolymers matrix and explores the concept of material production for further environmental and engineering solutions. Geopolymers were synthesized by dissolving sulfur in the alkaline activator of sodium hydroxide and sodium silicate in different proportions. The Alkaline solution was then mixed with metakaolin to synthesize the geopolymer matrix. Adding sulfur from 0 wt.% to 5 wt.%, compared with metakaolin, was found to lead to an increase in the compressive strength of the geopolymer from 22.5 MPa to 29.9MPa. When sulfur is between 5 wt.% and 15 wt.%, a decrease in compressive strength was observed to 15.7 MPa, which can be explained by defects and voids in the geopolymer microstructure through the solubility of excess sulfur and thus the formation of defects and voids in the geopolymer microstructure. Because of the incorporation of sulfur into the geo-polymer, a compact and dense microstructure is formed as reported in the SEM analysis. XRD analysis shows that besides quartz and Analcime, a new phase, Al2·H10·O17·S3, is also formed as a result of sulfur dissolution in alkaline activator of geopolymer.

The work reports a facile synthesis of high thermally-stable nanocrystalline anatase TiO2 nanoparticles (NPs) doped with different atomic concentrations (0.5, 1.0, 3.0, and 6.0%) of Gd3+ and Nd3+ ions by a template-free and one-step solvothermal process, using titanium(IV) butoxide as titanium precursor and dimethyl sulfoxide (DMSO) as solvent. The structure and morphology of the Gd3+, Nd3+, and 0.5%Gd3+-0.5%Nd3+/doped TiO2 NPs have been characterized by using various analytical techniques. The Gd3+/ and Nd3+/TiO2 molar ratios were found to have a pronounced impact on the crystalline structure, size, and morphology of TiO2 NPs. X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) studies revealed the proper substitution of Ti4+ by Gd3+ and Nd3+ ions in the TiO2 host lattice. The as-prepared Gdx/TiO2, Ndx/TiO2, and Gd1.0/Ndx/TiO2 bimetallic NPs, x = 0.5, 1.0, 3.0, and 6%, have been investigated as electrocatalysts for hydrogen evolution reaction (HER) in 1.0 M KOH solution using a variety of electrochemical techniques. At any doping percentage, the Gd1.0/Ndx/TiO2 bimetallic NPs showed higher HER catalytic performance than their corresponding counterparts i.e. Gdx/TiO2 and Ndx/TiO2. Upon increasing the Nd content from 0.5 to 6.0%, the HER catalytic performance of the Gd1.0/Ndx/TiO2 bimetallic NPs was generally enhanced. Among the studied materials, the bimetallic Gd1.0/Nd6.0/TiO2 NPs emerged as the most promising catalyst with an onset potential of -22 mV vs. RHE, a Tafel slope of 109 mV dec-1, and an exchange current density of 0.72 mA cm-2. Such HER electrochemical kinetic parameters are close to those recorded by the commercial Pt/C (onset potential: -15 mV, Tafel slope: 106 mV dec-1, and exchange current density: 0.80 mA cm-2), and also comparable with those measured by the most active electrocatalysts reported in the literature. The synergistic interaction of Gd and Nd is thought to be the major cause of the bimetallic catalyst's activity.

This study was conducted to compare the fertility and hatchability performance of the indigenous helmeted guinea fowls and exotic birds of the French strain, and predict egg weight from egg indices in Nigeria. A total of 300 randomly selected 8-month old guinea fowls comprising 150 indigenous (30 males and 120 females) and 150 French strain (30 males and 120 females) were utilized in the study. From these, a total of 240 randomly selected eggs (120 per genetic group) were used separately for the reproductive and egg quality assessment. The fertility and hatchability parameters were subjected to descriptive statistics, while the seventeen egg quality parameters were analysed using T-test, phenotypic correlation, principal component analysis, multiple linear regression and CHAID decision tree. Percentage fertility (90.0 versus 73.3%) and hatchability (66.7 versus 56.8%) were higher in the French strain compared to their indigenous counterparts. The egg quality parameters of the French strain were higher (P<0.05) than those of their indigenous counterparts with the exception of egg shell index (18.88±0.79 versus 16.41±0.69) and haugh unit (92.37±3.13 versus 91.09±3.22). However, the mean yolk/albumen ratio was similar (P>0.05). The phenotypic correlation coefficients between egg weight and egg quality indices in both genetic groups ranged from low to high values [-0.05-0.95 (indigenous); -0.19-0.96 (French strain)]. Three principal components sufficiently accounted for the variations in the egg quality traits of both genetic groups. The CHAID algorithm was more consistent in egg weight prediction with egg width as the primary explanatory variable. The present information may guide breeding and management strategies geared towards the improvement of the reproductive and egg quality traits of the helmeted guinea fowls.

The coevolution of species drives diversity in animals and plants and contributes to natural selection, whereas in host–parasite coevolution, a parasite may complete an incomplete evolutionary/developmental function by utilizing the host cell’s machinery. Analysis of related older data suggests that Plasmodium falciparum (P. falciparum), the pathogen of malaria tropica, cannot survive outside its human host because it is unable to perform the evolutionarily first protein glycosylation of serologically A-like, O-GalNAcα1-Ser/Thr-R, Tn antigen (“T nouvelle”) formation, owing to its inability for synthesizing the amino sugar N-acetyl-d-galactosamine (GalNAc). This parasite breaks the species barrier via hijacking the host's physiological A-like/Tn formation through abundantly expressing serine residues and creating hybrid A-like/Tn structures, which in the human blood group O(H) are attacked by the germline-encoded nonimmune polyreactive immunoglobulin M (IgM), exerting the highly anti-A/B/H-aggressive isoagglutinin activities. These activities physiologically undergo the ABO(H) blood group phenotype formation, occurring on the surfaces of red blood cells (RBC), epithelial and endothelial cells and on plasma proteins by identical glycosylation, performed by the ABO(H)-allelic glycotransferases, phenotypically downregulating the anti-A/B/H-reactive IgM (isoagglutinin) activities in the non-O blood groups. ABO(H) phenotype diversity, this way glycosidically linked and molecularly connected to humoral immunity, becomes exposed to the evolution.

The increasing cancer burden is a major health concern in Arab countries with variations in cancer profiles. Given the limited oncology research output and scarce data on cancer trial participation in the Arab region, this study explored the therapeutic cancer trial landscape in Arab countries over the past 20 years. A bibliometric analysis of the PubMed database was conducted on primary publications of therapeutic trials with a participating Arab center. Arab countries participated in 320 published cancer-related therapeutic trials (2000‒2021). There was a consistent increase in the number of trials, sample size, multiregional site participation, and number of randomized trials. However, most trials were small, did not receive external funding, and included a single Arab site. Compared with Arab-only trials, trials with joint non-Arab sites were larger (p = .003) and more likely to be externally funded (p < .001). Citation numbers and journal impact factors were higher in trial publications with joint non-Arab authorship than those without (p < .001, for both). Despite improving conduct and publication records of oncology trials with Arab centers, cancer trial participation remains limited in Arab countries. Concerted efforts are required to encourage sponsorship and international collaboration in this region.

In this study, the olive pomace was considered because of its importance in the environment. So, this study carried out to estimate the total nitrogen content and the fatty acids profile of olive pomace. The olive pomace samples were collected from Irbid, Jarash, Ajloun and Mafraq during the harvesting season 2014 to study the biochemical characteristics of fatty acid composition and the total nitrogen (TN) content. The total nitrogen content was determined by standard Kjeldahl method and the fatty acid profile was detected by gas chromatography (GC). The results show that the total nitrogen content ranged from (0.39 ± 0.0) to (0.62 ± 0.02) with statistically significant difference suggesting that the composition of matrices and their percentage may be responsible for composition of amendments. The calculated total protein percentage ranged between (2.43 ± 0.00) to (3.87 ± 0.17). Also, 13 different fatty acids were quantitatively profiled and quantitated. Oleic acid (C 18:1) was found to be the highest percentage of all other fatty acids and ranged between (59.03%) and (63.81%), moreover the C 18:1/C 18:2 (oil quality) was calculated and C.V% showed variation meaning that nutritional implication could affect the oxidative stability of oils. In conclusion, OP by-product could give a sustainable and alternative-cheap source for fertilizers, pharmaceutical industries, cosmetics and other industries.

As part of our ongoing silybin project, this study aims to introduce a basic nitrogen-containing group to 7-OH of 3,5,20-O-trimethyl-2,3-dehydrosilybin or 3-OH of 5,7,20-O-trimethyl-2,3-dehydrosilybin via an appropriate linker for in vitro evaluation as potential anti-prostate cancer agents. The synthetic approaches to 7-O-substituted-3,5,20-O-trimethyl- 2,3-dehydrosilybins through a five-step procedure and to 3-O-substituted-5,7,20-O-trimethyl-2,3- dehydrosilybins via a four-step transformation have been developed. Thirty-two nitrogen-containing derivatives of silybin have been achieved through these synthetic methods for the evaluation of their antiproliferative activities towards both androgen-sensitive (LNCaP) and androgen-insensitive prostate cancer cell lines (PC-3 and DU145) using WST-1 cell proliferation assay. These derivatives exhibited greater in vitro antiproliferative potency than silybin. Among them, 11, 29, 31, 37, and 40 were identified as five optimal derivatives with IC50 values in the range of 1.40–3.06 µM, a 17- to 52-fold improvement in potency as compared with silybin. All these five optimal derivatives can arrest the PC-3 cell cycle in the G0/G1 phase and promote PC-3 cell apoptosis. Derivatives 11, 37, and 40 are more effective than 29 and 31 in activating PC-3 cell apoptosis.

Protein degradation is a biological phenomena essential for cellular homeostasis and survivor. Selective protein degradation is performed by the ubiquitination system which selectively target proteins that need to be eliminated and lead them to proteasome degradation. In this review, we focus on the ubiquitin-conjugating enzyme E2 O (UBE2O) and highlight the role of UBE2O in many biological and physiological process. We further discuss the UBE2O implications in various human diseases, particularly in leukemias and solid cancers and suggest how UBE2O targeting could be novel strategy in the treatment of different human neoplasia.

In this paper, we introduce a novel controlled quantum communication protocol utilizing a quantum random walk involving one sender, one receiver, and multiple controllers. Inspired by classical random walk theory, quantum random walk serves as the foundation of our proposed protocol. With this protocol, we demonstrate the ability to transfer any n- dimensional quantum state to any party facilitated by any m number of controllers. Furthermore, any of the (m+1) individuals has the freedom to accept the role of the receiver. Rigorous testing of the protocol’s performance is conducted through quantum state tomography. We have run different variations of the circuits in IBMQ QASM simulator. Additionally, we explore the effectiveness of a weak measurement-based protocol designed to mitigate amplitude-damping noise’s detrimental effects on quantum states. By analyzing fidelity versus amplitude damping noise-strength plots for scenarios with and without the weak measurement protocol, we provide valuable insights into its protective capabilities across various levels of noise. These find- ings illuminate the protocol’s potential applications in quantum information processing

A new two-step method for developing a nanocomposite of polypropylene (PP) decorated with photocatalytically active TiO2 nanoparticles (nTiO2) is proposed. This method involves low-temperature plasma functionalization of polypropylene followed by ultrasound-assisted anchoring of nTiO2. The nanoparticles, polymeric substrate, and resultant nanocomposite were thoroughly characterized using nanoparticle tracking analysis (NTA), microscopic observations (SEM, TEM, EDX), spectroscopic investigations (XPS, FTIR), thermogravimetric analysis (TG/DTA), and water contact angle (WCA) measurements. The photocatalytic activity of the nanocomposites was evaluated through the degradation of methyl orange. The individual TiO2 nanoparticles ranged from 2-6 nm in size. Oxygen plasma treatment of PP generated surface functional groups (mainly -OH and -C=O), transforming the surface from hydrophobic to hydrophilic, which facilitated efficient deposition of nTiO2. Optimized plasma treatment and sonochemical deposition parameters resulted in an active photocatalytic nTiO2/PP system, degrading 80% of methyl orange under UVA irradiation in 200 minutes. The proposed approach is considered versatile for the functionalization of polymeric materials with photoactive nanoparticles and, in a broader perspective, can be utilized for the fabrication of self-cleaning surfaces.

Choking and foreign body aspiration are significant causes of mortality and morbidity in young youngsters. This study aimed to investigate the effects of education programs on school students ' knowledge, attitude, and practice towards a choking person. This quasi-experimental study with a pretest-posttest control group design included a total of 282 school students. The students were divided into an intervention group (n = 141) and a control group (n = 141). After both groups completed the pretest, the intervention group received an education program on first aid for a choking person. Then, both groups were subjected to a posttest at the end of the program. The descriptive and inferential statistics analyzed the data. There were no significant differences between the two groups within the study parameters at the pretest (P = > 0.05). However, at posttest, a significant difference was observed in the knowledge (p = 0.001), attitude (p = 0.024), and practice (p = 0.001) of the intervention group compared to the control group. The intervention group showed significant improvement in the students’ knowledge, attitudes, and practices regarding first aid for a choking person. We suggest a continuous training program to improve the competency of first aid for a choking person.

The objective of this study was to investigate the impact of athletes' respiratory muscle strength, as assessed through maximal inspiratory (MIP) and expiratory pressure (MEP), on aerobic endurance, as indicated by maximal oxygen consump-tion (Max VO2) kinetics. Respiratory muscle strength was assessed using a digital spirometer (Pony FX Cosmed, Italy), while maximal oxygen utilization capacity was measured using a breath-by-breath automatic portable gas analysis system (Cosmed K5, Italy). Statistical analysis was conducted utilizing SPSS 22.0. Based on the standardized regression coefficients (β), it was found that MEP (mean ± SD: 130.95 ± 42.82) and inspiratory diaphragmatic circumference values significantly influenced ventilatory equivalent (VE), oxygen consumption (VO2), and carbon dioxide pro-duction (VCO2). Conversely, the remaining predictor variables did not exhibit a sig-nificant effect on VE (mean ± SD: 134.80 ± 36.69), VO2 (mean ± SD: 3877.52 ± 868.47 ml), and VCO2 (mean ± SD: 4301.27 ± 1001.07 ml). In contrast, measurements of chest circumference (mean ± SD: 91.40 ± 10.72 cm), MEP, and diaphragmatic cir-cumference during inspiration (mean ± SD: 95.20 ± 10.21 cm) were found to signifi-cantly impact Max VO2 (mean ± SD: 58.52 ± 10.74 ml/kg/min), while the other pre-dictor variables did not demonstrate a significant effect on Max VO2. Conclusively, the study revealed that measured values of diaphragmatic circumference during inspiration and MEP exerted a notable influence on Max VO2, VE, VO2, and VCO2. Our findings underscore the importance of considering respiratory muscle strength in assessing and enhancing athletes' aerobic performance. These insights contribute to a deeper understanding of the interplay between respiratory function and exercise capacity, offering potential avenues for optimizing training regimens and perfor-mance outcomes in athletic contexts.

This study inscribes itself in the global discussion about the issue of environmental awareness, beliefs and behaviors. Here we focus on the role that cultural differences and scientific media dieting play in explaining heterogeneities in students' awareness and expectations about the two environmental issues of deforestation and species (plant and animal) extinction in the Middle East and North America. To this end, we use the cross-sectional survey data of the OECD's Program for International Student Assessment (PISA) 2015, along with seemingly unrelated Bi-variate ordered Probit modeling techniques. The results show that compared to their North American Counterparts, students' in the Middle East are 14.2% less aware of, and 14.5% less optimistic about the issue of deforestation, while 38.9% less aware of, and 59.0% less optimistic about the issue of species extinction. In addition, we found that science club attendance and broad science reading in books are the two most effective communication media for raising students awareness about the two environmental issues. In fact, every one level increase in students' awareness is found to raise their optimism by 20.4% for the issue of deforestation, and 15.0% for the issue of plant and animal extinction. Therefore raising young people environmental awareness and optimism through proper communication strategies, could be invaluable for achieving an economic development in line with our need to preserve the natural environment and ecosystem services for generations to come.

Silybin is a natural compound extensively studied for its hepatoprotective, neuroprotective and anti-cancer properties. Envisioning the enhancement of silybin potential by suitable modifications in its chemical structure, here, a series of new 7-O alkyl silybins derivatives were synthesized by Mitsunobu reaction starting from the silybins and tyrosol-based phenols, such as tyrosol (TYR, 3), 3-methoxytyrosol (MTYR, 4) and 3-hydroxytyrosol (HTYR, 5). This research sought to explore the antioxidant and anticancer properties of new eighteen derivatives and their mechanisms. In particular, the antioxidant properties of new derivatives outlined by DPPH assay, showed a very pronounced activity depending on the tyrosyl moiety (HTYR&gt;MTYR&gt;&gt;TYR). A significant contribution of the HTYR moiety was observed for silybins and 2,3-dehydro-silybin based derivatives. According to the very potent antioxidant activity, 2,3-dehydro-silybin derivatives 15ab, 15a and 15b exerted the most potent anticancer activity in human prostate cancer PC-3 cells. Furthermore, flow cytometric analysis for cell cycle and apoptosis revealed that 15ab, 15a and 15b induce strong G1 phase arrest and increase late apoptotic population in PC-3 cells. Additionally, western blotting for apoptotic marker cleaved caspase-3 confirmed apoptosis induction by these silybin derivatives in PC-3 cells. These findings hold significant importance in the investigation of anticancer properties of silybin derivatives and strongly encourage swift investigation in pre-clinical models and clinical trials.

This paper investigates the role of English language proficiency (ELP) as a measure of cultural integration on U.S. immigrant families’ economic integration, as measured by annual earnings, and health care market integration, as captured by annual medical care spending. Bayesian Markov Chain Monte Carlo (MCMC) estimation of a mixed bivariate ordered probit (MBOP) model of annual earnings and medical care spending is conducted using a nationally representative pooled cross-sectional sample data from the U.S. National Health Interview Surveys (NHIS). The results reveal that limited English proficiency is associated with lower marginal earnings propensities (-$44.83, -$50.66, and -$56.97), and higher marginal medical care spending propensities ($8.09, $6.09, and $4.32) for each of the three decreasing levels of ELP. Furthermore, we find a small yet statistically significant positive 7.2% correlation between immigrant families’ annual earnings and medical care spending propensities. Therefore investing to raise immigrants’ families ELP in the U.S. would not only contribute to more effective socio-economic integration, but also strengthen the U.S. workforce and economy for decades to come.

To improve efficacy and safety of sunscreen emulsions, UV‐filter skin permeation could be kept as low as possible by reducing UV‐filter content or changing emulsion composition. In this work, different lipid phase ratio (12, 14 and 16% w/w) were assessed for their ability to affect the technological and sensory properties of O/W emulsions in which bemotrizinol (BMTZ), a broad spectrum sunscreen agent, was incorporated free or loaded into nanostructured lipid nanocarriers (NLC) to reduce its release from the vehicle and, hence, its skin permeation. The following technological properties were evaluated in vitro by suitable methodologies: spreadability, viscosity, pH, occlusion factor, BMTZ release, sun protection factor (SPF). Sensory attributes were assessed by trained panelists in three different phases: before/during pick‐up, rub‐in, after application. Raising the lipid phase ratio led to an increase of viscosity and to a corresponding drop of spreadability while the incorporation of BMTZ‐loaded NLC determined a decrease of occlusion factor and an increase of SPF. No BMTZ release was observed from all emulsions. Sensory attributes were mainly affected by lipid phase ratio. These results suggest that lipid phase ratio and BMTZ incorporation into NLC could contribute to determine technological and sensory properties of O/W emulsions.

The blue sepal color of hydrangea is due to a metal complex anthocyanin composed of 3-O-glucosyldelphinidin (1) and an aluminum ion with the co-pigments 5-O-caffeoylquinic acid (2) and/or 5-O-p-coumaroylquinic acid (3). The three components, namely, anthocyanin, Al³⁺ and 5-O-acylquinic acids, are essential for blue color development, but the complex is unstable and only exists in aqueous solution. Furthermore, the complex did not give analyzable NMR spectra or crystals. Therefore, many trials to determine the detailed chemical structure of the hydrangea-blue complex have failed to date. Instead, via experiments mixing 1, Al³⁺ and 2 or 3 in a buffered solution at pH 4.0, we obtained the same blue solution derived from the sepals. However, the ratio was not stoichiometric but fluctuated. To determine the composition of the complex, we tried direct observation of the molecular ion of the complex using electrospray-ionization mass spectrometry. In a very low-concentration buffer solution (2.0 mM) at pH 4.0, we reproduced the hydrangea-blue color by mixing 1, 2 and Al³⁺ in ratios of 1:1:1, 1:2:1 and 1:3:1. All solution gave the same molecular ion peak at m/z = 843, indicating that the blue solution has a ratio of 1:1:1 for the complex. By using 3, the observed mass number was m/z = 827 and the ratio of 1, 3 and Al³⁺ was also 1:1:1. A mixture of 1, 3-O-caffeoylquinic acid (4) and Al³⁺ did not give any blue color but instead was purple, and the intensity of the molecular ion peak at m/z = 843 was very low. These results strongly indicate that the hydrangea blue-complex is composed of a ratio of 1:1:1 for 1, Al³⁺ and 2 or 3.

Introduction of Cl- and O- atoms into C4-vinyl carbocations was studied by X-ray diffraction analysis and IR spectroscopy. Chlorine atoms are weak electron acceptors in ordinary molecules, but within vinyl carbocations, manifest themselves as strong electron donors that accept a positive charge. The attachment of a Cl atom directly to a C=C bond leads to an increase in the e-density on it, exceeding that of the common double bond. The positive charge should be concentrated on the Cl atom, and weak δ- may appear on the C=C bond. More distant attachment of the Cl atom—to a C atom adjacent to the C=C bond—has a weaker effect on it. If two Cl atoms are attached to the Сγ atom of the vinyl cation, as in Cl2СγСδHСαHCH3, then the cation switches to the allyl type with two practically equivalent and almost uncharged СγСδСα bonds. When such a strong nucleophile as the O atom is introduced into the carbocation, a protonated ester molecule with a C-O(H+)-C group and a C=C bond forms. Nonetheless, in the future, there is still a possibility of obtaining carbocations with a non-protonated C-O-C group.

Agricultural product like cassava produces huge amounts of waste when processed to consumable goods. The waste generated is generally considered to contribute largely to environmental pollution. This study therefore investigates the waste management practice that is adopted by cassava processors in Ogun State, Nigeria. Five (5) Local Government Areas (LGAs) dominant in processing cassava were selected for the study on the basis of spatial location distribution; landmass and population. The survey involved the use of structured questionnaires administered to cassava processors of the selected LGAs. The Statistical Package for Social Sciences (SPSS) software application and descriptive statistics were used for data analysis. Results of the analysis show that majority (70%) of the cassava processors are females. Cassava peel constitutes 10% of the waste produced, of which 91% are heaped at refuse dump in most communities. Results also reveal that 86.3% of cassava residues are used for animal feeds. Other findings show that the peels when dried are used as bio-fuel for cooking and there is a significant potential for biogas production. From the data captured from respondent during the study, most processors are willing to pay for an improved waste management system. The study therefore suggests proper waste management of cassava waste to minimize environmental pollution.

The objective was to analyze the effects of adding anthocyanin delphinidin-3-O-sambubioside and cyanidin-3-O-sambubioside of Hibiscus sabdariffa L. in animal diets. Scientific articles published before 2021 in clinics, pharmacology, nutrition, and animal production were included. The grains/concentrate, metabolic exigency, and caloric stress contribute to increasing the reactive oxygen species (ROS); the excess of ROS unbalance the oxidants and antioxidants. Cyanidin-3-O-sambubioside and delphinidin-3-O-sambubioside have antioxidant, antibacterial, antiviral, and anthelmintic activities. In the rumen, anthocyanin might show interactions and/or synergisms with substrates, microorganisms, and enzymes which could reduce the fiber degradability, but increase the potential methane (CH4) emissions; since anthocyanin interferes in the biohydrogenation of fats, they increase the fat milk and meat quality. Anthocyanins reduce plasma oxidation and deposit in tissues, increasing the milk and meat antioxidant activities. Cyanidin-3-O-sambubioside and delphinidin-3-O-sambubioside act as inhibitors of the angiotensin-converting enzyme (ACEi) and rennin expression which may improve milk yield (there is not enough evidence in ruminants, though). Polyphenols affect the reproductive potential. Sub products of HS contain as many amounts of polyphenols as calyces, and their inclusion in diets would positively affect the average daily gain and fat meat quality. Including HS in ruminant diets can improve the meat and milk quality.

Given the Income enabling nature of education as stipulated by human capital theory, it can be postulated that “ceteris paribus”, households with formally educated heads experience less food insecurity and monetary poverty than those with uneducated heads. We test this claim in the case of Burkina Faso, using the 2014 National Survey on Households Living Conditions, along with semi-parametric modeling techniques. In its design the study uses households “willingness and ability” to spend annually on food consumption a per-capita amount above the food poverty line of 102,040 CFA Franc to characterize “household food security”, and households “unwillingness or inability” to spend above the overall poverty line of 153,530 CFA Franc to characterize “monetary poverty”. In addition, the study relies not only on single equation multivariate probit and logit specifications, but also on both fully parametric and semi-parametric bivariate probit representations of food insecurity and monetary poverty. The results show that relaxing the linearity and independence assumptions through joint semi-parametric bivariate modeling captures better the true effects of heads of households’ educational attainment on households' food insecurity and monetary poverty. In fact, compared to households headed by someone with no education, those headed by someone with a primary, secondary or higher education are respectively 19.8% , 49.7% and 118.9% less likely to experience food insecurity, and respectively 40.1%, 77.0% and 172.3% less likely to experience monetary poverty in Burkina Faso. In addition, the experience of food insecurity and monetary poverty are highly correlated at 92.7%, suggesting that educational policies that alleviate poverty in Burkina Faso should also impact positively food security in the country.

Relying on Random Utility Theory (RUT) as the guiding mechanism for the Data Generating Process (DGP), this paper uses households consumption choices on cooking fuel, drinking water, and sanitation from the 2014 United States Agency for International Development's (USAID) Demographic and Health Survey (DHS) data on Burkina Faso, to characterize and investigate the inter-linkages between health consciousness and environmental consciousness, and their relationship with wealth in a low income country context. We achieve this by specifying sequentially three econometric modeling frameworks: the first one being independent binary probit (IBP) models to describe each choice process, followed by a fully parametric trivariate probit (FPTP) model to account for choice dependency, and finally by a semi-parametric trivariate probit (SPTP) model to further relax the linearity assumption. Based on the Akaike Information criteria (AIC) and the estimated Trivariate model correlation coefficients, the SPTP framework is found to be the best specification for describing the observed consumption behaviors. The results show that increased wealth level raises households health and environmental consciousness, while leaving the relative preference ordering over the elements in the household consumption basket unchanged.

Oil revenues and external debt might have stimulated economic growth in the oil exporting countries via investment in capital projects. The paper estimated economic growth on oil revenues and external debt after controlling public investment and population growth over the period 1970-2015. Following the confirmation of the order of integration, our analysis is based on autoregressive distributed lag bound testing to cointegration approach. The key findings are that oil revenues and public investment contributes to Nigeria’s economic growth. However, our findings also indicate that external debt and population growth retards growth. The study suggests that minimizing fiscal deficits and unnecessarily foreign loans by creating tax avenues through the development of the non-oil sectors would reduce the dependency syndrome on a single commodity (oil) in Nigeria.

Solar cell layers technology has achieved global standing in the solar cell layers deposition process, and it covers the innovative methods and techniques in significant applications. Recent solar cell layers technology has an advanced interest in a refined approach to enhance performance and highlights the importance of recent proficient procedures for manufacturing. For example, the application is used to search for novel materials for solar cells' layers to clarify the current energy crisis. The technological process and various types of solar cells depend on climate change. Among them, layers of solar cells and silicon wafer solar cells are very encouraging. Solar cell layers technology has led to solar cells being a more reasonable active option in design and production. The productivities facilitated by new solar cells still need to be enhanced for the various processes involved in the additional enhancement from Copper Indium Gallium Selenide (CIGS) microfilms to solar cell crystal structure dye-sensitized solar cells. The hydrophobic coating works as an anti-dust coating, enhancing efficiency and decreasing the cost of cleaning solar cells. In Saudi Arabia Majmaah City, most solar projects are in dry regions, where the dusty weather reduces solar cell efficiency. Therefore, combining these two properties and applying an anti-reflective and superhydrophobic coating will increase solar cell efficiency by 20%. Solar cells' crystal structure results are substituted with layers or new materials to balance environmental impact and toxic nature.

The aim of this paper is to investigate the amenability modulo an ideal of Banach algebras with emphasis on applications to homological algebras. In doing so, we show that amenability modulo an ideal of A^** implies amenability modulo an ideal of A. Finally, for a large class of semigroups, we prove that l¹(S)^** is amenable modulo Iσ^** if and only if an appropriate group homomorphic image of S is finite where Iσ is the closed ideal induced by the least group congruence σ.

This paper intends to discuss SSLs, how they work, their advantages and drawbacks. It will end with the author’s thoughts on the efficacy of the system and whether it is a viable solution for the majority of network security problems or if those drawbacks prevent that.

Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylation. These epigenetic modifications can influence chromatin structure and function without altering the DNA sequence. Histones can also undergo post-translational O-GlcNAcylation, a rather understudied modification that plays critical roles in almost all biological processes and is added and removed by O-linked N-acetylglucosamine transferase and O-GlcNAcase, respectively. This review provides a current overview of our knowledge of how O-GlcNAcylation impacts the histone code both directly and by regulating other chromatin modifying enzymes. This highlights the pivotal emerging role of O-GlcNAcylation as an essential epigenetic marker.

This review aims at studying the phytochemistry and biological activities of some selected Apocynaceae plants. Eleven members of this family were reviewed for their phytochemistry and biological activities. Interestingly, the commonly isolated compounds reported from Mondia whitei (Hook.f.) Skeels, Secondatia floribunda A. DC, Carissa carandas, Tabernaemontana divaricate, Nerium oleander, Wrightia tinctoria, T. divaricate, Alstonia scholaris, Carrisa spinarum Linn, Thevetia peruviana and Caralluma lasiantha were triterpenoids, flavonoids, phytosterols, cardiac glycosides and lignans. All of them exhibited remarkable biological activities, mostly similar to each other. This review provides a detailed insight into the pharmacological activities of these selected members of this family.

This article takes an approach to explaining the behavioral manifestations of the decision making in US companies’ offer of health insurance that is grounded not only on their cost minimizing behavior, but also in a humanness dimension based on the African concept of Ubuntu. In this way, we define an Ubuntu based Random Utility modeling framework, describing the choice process as a tripartite decision making, and implemented using a nationally representative random sample of 1,061 American companies from the Dunn and Bradstreet Business data, supplied by Survey Sampling International to the Associated Press-NORC Center for Public Affairs Research. The results from the three sequentially implemented specifications showed that the relationship between management culture and health plan offering strategy is dependent on other relevant co-variates, which when left out, leads to the problem of omitted variables bias. However, when all variables are included but assumed to enter the relationship exogenously, this results in management culture not having any statistically significant effect on companies' decisions about scope of health plan offering. When the exogeneity assumption is relaxed through a recursively Bivariate Probit model, the system of two equations produces a highly significant management culture effect. In fact, in this later case we see that companies with groups and formal committee management culture are 1.58 times less likely to choose a multiple plan strategy over a single plan strategy, hence failing to show the more wholesome plan offering that would theoretically prevail under Ubuntu style management.

In order to meet the needs of an increasingly complex research landscape, researchers engage in “collaborative prosumption” through open data sharing and reuse. Although significant gains have been achieved in this regards because of growing requirements from funding agencies, governments and journals, the question of how reuse of openly available data for new research contribute to sustainability is yet to be appropriately addressed in the literature. Therefore, relying on a three stage stratified clustered random sampling of the Journal of Applied Econometrics data archive (JAEDA), the present research provides a case study of the value of research data recycling for sustainable research and economic development. More specifically our analysis show that reformatting from wide to long format, openly shared equity price index data on eleven European countries’ extracted from JAEDA, and augmented with country level geospatial Meta data, provides a new basis for interesting descriptive analytics and spatio-temporal econometric modeling and inference. Given the ever-increasing volume of openly available research data, our study provides a first-hand insight on open data reuse, which should benefit all stakeholders in the research community, as they seek sustainable solutions for scientific productivity and progress.

Relying on the United Arab Emirates (UAE) extract from the cross-national data sample on the environmental affection and cognition of adolescent students, and seemingly unrelated bivariate weighted ordered probit regression modeling, this study adopts a national perspective to investigate the determinants of adolescent students' awareness and expectations about nuclear power technology and nuclear waste in the UAE. Identification of model parameters is achieved through maximum simulated likelihood estimation. The findings show that each level increase in UAE youth's interest in ecosystem services and sustainability raises their awareness of nuclear electrical power and nuclear waste by 13.5%, while reducing by 2.4% their level of optimism towards the technology. Furthermore, we find significant heterogeneity in youth awareness and expectations about nuclear power technology across the seven Emirates. Accounting for all other factors (including interest in ecosystem services), UAE youth awareness about nuclear electrical power technology appears to not significantly influence their expectations about the evolution of this technology for the next 20 years. Given that the UAE first nuclear power plant ``Barakah'' is scheduled to start operations end of 2019 beginning 2020, and the typical long life-span of nuclear wastes, our results provide important insights for developing sustainable nuclear energy policies and establishing a long-term nuclear energy program in the UAE.

This paper models the factors explaining households members economic well-being in Burkina Faso, with a focus on the relative influence of gender inequality in literacy status. It does so, using data from the 2014 survey on household living conditions and a semi-parametric bi-variate sample selection modeling approach. This approach compared to the classic Heckman two-step estimator is methodologically innovative because it deals simultaneously with non-random sample selection using conventional systems of two equations, non-linear covariates' effects using spline approach, and the non-normal bivariate distribution using copula functions. The graphical results from the Lorenz curves combined with the numerical Atkinson and Gini coefficients suggest that inequality in overall per-capita consumption spending among households headed by literates is higher than that of their illiterate counterparts in 2009 and 2014. However, independently of the head of household’s literacy status, the level of inequality in total economic well-being decreased from 2009 to 2014. Using the poverty indices of Watts, Sen, Foster ( alpha= 1)) we found that poverty among households headed by literates is lower than that of their illiterates counterparts for both years, although overall poverty decreased nationally between 2009 and 2014. The results also show that although the gender inequality in literacy status does not translate into inequalities in non-food wellness, it does however for food-wellness as female headed households have 38.9% less per-capita food consumption spending than their men counterparts. Combining both food and non-food consumption spending, total economic well-being also seems to exhibit gender inequality as female headed households now have relatively 26.7% less combined per-capita consumption spending.

The climate crisis necessitates a global shift to achieve a secure, sustainable, and affordable energy system toward a green energy transition reaching climate neutrality by 2050. Because of this, renewable energy sources have come to the forefront and the research interest in microgrids which rely on distributed generation and storage systems has exploded. Furthermore, many new markets for energy trading, ancillary services, and frequency reserve markets have provided attractive investment opportunities in exchange for balancing the supply and demand of electricity. Artificial intelligence can be utilized to locally optimize energy consumption, trade energy with the main grid, and participate in these markets. Reinforcement learning (RL) is one of the most promising approaches to achieve this goal because it enables an agent to learn optimal behavior in a microgrid by executing specific actions that maximize the long-term reward signal/function. The study focuses on testing two optimization algorithms: logic-based optimization and reinforcement learning. This paper proposes an optimization algorithm based on reinforcement learning in an industrial microgrid that is capable of trading energy with the main grid, providing significant cost savings. The RL-based approach is implemented in Python based on real data from the site and in combination with MATLAB-Simulink to validate its results. The application of the RL algorithm achieved an average monthly cost saving of 20% compared to logic-based optimization and 86% savings compared to not using any optimization. These findings contribute to digitalization and decarbonization of energy technology and support fundamental goals and policies of the European Green Deal.

This study uses data from the pilot project "Community Monitoring for Better Health and Education Services Delivery Project'' in Burkina Faso, to model the joint impact of generic essential drugs and nursing staff supplies constraints on access to primary health care in the country. The results show that statistical endogeneity of supply side constraints are present in the standard univariate probit specification of access to care. However, when accounted for, the resulting Trivariate Probit model shows that although shortages of generic essential drugs supply do not seem to constitute a significant barrier to access in Burkina Faso, shortages in nursing staff supply do. In fact, the likelihood of primary care access is reduced by 85.5% among those that reported having experienced a shortage in nursing staff, while paradoxically increasing by 60.3% among those that reported having experienced a shortage in generic essential drugs. A potential explanation for these findings is that overall the health care needs in the three surveyed regions in the country were more linked to primary health care services consumption from nurses, although further research would be important to clearly elucidate the position of health goods such as generic essential drugs.

This research contributes to the overall debate on education for sustainable development (ESD) by shed- ding lights on the contributing role of formal education to the contemporaneous dynamics of literacy, labor market participation and poverty reduction in Africa, with a focus on Burkina Faso. The study uses a semi-parametric recursive trivariate probit modeling approach, and data from the 2014 National Survey on Household Living Conditions in Burkina Faso. The results show that the embraced systemic approach in this analysis is statistically signi cant as shown by the 95% con dence intervals on the three correlation coeffcients in the model. Furthermore, education does improve literacy skills, however improved literacy skills in itself does not guaranty active labor market participation in Burkina Faso. Active labor market participation seem to be affected by labor market rates of return, and individual reservation wage (or income). When labor market rate of return is short of high literacy skilled individuals' reservation wage, then the natural response is a choice of inactivity in the labor market, by the later group. Simultaneously however, it is found that active labor market participation leads to poverty reduction; therefore, in addition to new industrial policies for structural transformation of the economy, policy makers in Burkina Faso should consider education and minimum wage reforms to give highly literate household members the incentive to be active in the labor market.

This paper investigates the effects of Inter-generational co-residence on health care market, and labor market outcomes, to see whether or not living under the same roof with at least one parent matters in health care market, and labor market behaviors in post-Affordable-Care Act (ACA) USA. The adopted analytical strategy involves not only looking at the gender differences in co-residence, and its effects on outcomes in the two markets, but also accounting for co-residence endogeneity following the recent literature. Unlike the recent literature that relies on instrumental variables methods, this study adopts a switching regression approach, defining inter-generational co-residence as an endogenous selection process using a binary probit equation, and modeled jointly with the extensive margins and intensive margins in the two markets. This novel approach results in a recursive trivariate probit model for each market, and estimated using penalized maximum likelihood methods. The results suggest that ACA by reorganizing the US health care market, seems to have reduced significantly disparities in health care access among males and females based on race, region of residence, place of birth, and citizenship. However not only do we observe significant differences in inter-generational co-residence status between males and females, we also find significant inequalities in the effects of co-residence on health care market, and labor market outcomes. In fact, co-residence is found to increase health care expenditure by 56.7% among females, while this figure increases to 74.2% among males. In addition co-residing individuals, while spending 69.7% more on health care annually are 1.22 times more likely to access health care, but 31% less likely to use health care intensively during the year. In the labor market, co-residence is found to reduce significantly hours of weekly labor supplied by 41% for females, and 55.6% for males. Furthermore co-residing individuals, while not significantly different in their likelihood of labor force participation, are 1.52 times less likely to work full time once they decide to participate, and also spend about 55.4% less time working in the labor market in post-ACA USA.

Understanding pollen and ovule fertility as factors influencing fruit and seed set is important in cassava breeding. Red light (RL) and plant growth regulators (PGRs) have been used to induce or enhance flowering and fruit set in cassava without any reference to effects on pollen viability or ovule fertilizability. This study investigated effects of field-applied RL and PGR on pollen viability and ovule fertilizability. Panels of cassava genotypes, with early or moderate flowering responses were used. RL was administered from dusk to dawn. Two PGRs, a cytokinin (6-benzyl adenine, BA) and an anti‑ethylene (silver thiosulphate, STS) were applied. Pollen viability was assessed basing on pollen grain diameter, in vitro stainability, in vivo germinability, ovule fertilizability and ploidy level. Treating flowers with RL led to increased pollen diameter from 143.6 to 148.5µm, stainability from 82.9 to 93.0%, ovule fertilizability from 52.0 to 56.9% in treated female flowers and 47.7 to 64.3% on using pollen from treated male flowers. Fruit set increased from 51.5 to 71.8% in RL-treated female flowers and from 53.7 to 71.1% when pollen from RL-treated male flowers was used. Seed set followed a trend similar to that of fruit set. Ploidy level of pollen from RL-treated flowers increased slightly and positively correlated with pollen diameter (R2 = 0.09*), ovule fertilization (R2 = 0.20*), fruit (R2 = 0.59*) and seed set (R2 = 0.60*); but negatively correlated with pollen stainability. Treating flowers with PGR did not affect pollen diameter and stainability, but increased ovule fertilizability from 42.9 to 64.9% and fruit set from 23.2 to 51.9% in treated female flowers and 31.3 to 54.7% when pollen from treated male flowers was used. Application of combined BA+STS on male flowers caused the highest ovule fertilizability, fruit and seed set efficiency, though this varied among study genotypes. These results show that RL and PGR treatment of flowers increases pollen viability and ovule fertilizability. This is important for planning pollination strategies in cassava breeding programmes.

An H-bond involves the sharing of a hydrogen atom between an electronegative atom to which it is covalently bound (the donor) and another electronegative atom serving as an electron acceptor. Such bonds represent a critically important geometrical force in biological macromolecules and, as such, have been characterized extensively. H-bond formation invariably leads to a weakening within the acceptor moiety due to the pulling exerted by the donor hydrogen. This phenomenon can be compared to a spring connecting two masses; pulling one mass stretches the spring, similarly affecting the bond between the two masses. Herein, we describe the opposite phenomenon when investigating the energetics of the C-H...O=C bond. This bond underpins the most prevalent protein transmembrane dimerization motif (GxxxG) in which a glycine C-H on one helix forms a hydrogen bond with a carbonyl in a nearby helix. We use isotope-edited FT-IR spectroscopy and corroborating computational approaches to demonstrate a surprising strengthening of the acceptor C=O bond upon binding with the glycine C-H. We show that electronic factors associated with the C-H bond strengthen the C=O oscillator by increasing the s-character of the -bond, lowering the hyperconjugative disruption of the -bond. In addition, a reduction of the acceptor C=O bond’s polarity is observed upon the formation of the C-H...O=C bond. Our findings challenge the conventional understanding of H-bond dynamics and provide new insights into the structural stability of inter-helical protein interactions.

Hadhramout Initiative Against Corona (HIAC ) formed a working group of clinicians relevant to the management of COVID-19 to formulate clinical practice guidelines (CPG) for clinicians caring for the patients infected with COVID-19 in Yemen. The regional guidelines on the management of COVID-19 were thoroughly reviewed and its applicability was assessed for Yemen. HIAC’s recommendations covered (2) sections: the first one is the diagnosis, including case definition, risk stratification of the affected cases, investigations (prioritization of reverse transcription-polymerase chain reaction (RT-PCR) testing, D-dimer, chest x-ray, and chest computed tomography, while the second part covers the treatments (mainly Favipiravir, Remdesivir, Hydroxychloroquine, and Glucocorticoid, Anticoagulants, and Supportive measures). In conclusion, the adoption of cost-effective and evidence-based guidelines in Yemen will standardize the management of the patients infected with COVID-19 and protect both the patients and the health care workers from malpractice.

Vaccination is one of the best approaches to control and eradicate foot-and-mouth disease (FMD). To achieve this goal, vaccines with inactivated FMD virus antigen in suitable adjuvants are being used in addition with other control measures. However, only a limited number of vaccine strains are commercially available which often have a restricted spectrum of activity against the different FMD virus strains in circulation. As a result, when new strains emerge, it is important to measure the efficacy of the current vaccine strains against these new variants. This is important for countries where FMD is endemic but also for countries that hold an FMD vaccine bank to be prepared for emergency vaccination. The emergence and spread of the O/ME-SA/Ind-2001 lineage of viruses posed a serious threat to countries which had OIE-endorsed FMD control plans and had not reported FMD for many years. In vitro vaccine matching results showed a poor match (r1-value &lt;0.3) to the more widely used vaccine strain O Manisa and less protection in a challenge test. This paper describes the use of O3039 vaccine strain as an alternative either alone or in combination with the O Manisa vaccine strain with virulent challenge by a O/ME-SA/Ind-2001d sub-lineage virus from Algeria (O/ALG/3/2014). The experiment included challenge at 7 days post vaccination (to study protection and emergency use) and 21 days post vaccination (as would be done in standard potency studies). The results indicated that the O3039 vaccine strain alone as well as the combination with O Manisa is effective against this strain of the O/ME-SA/Ind/2001d lineage offering protection from clinical disease even after 7 days post vaccination and with reduction in viraemia and virus excretion.

Omicron SARS-CoV-2 variants have dominated the strains of COVID-19 circulating worldwide for the last two years. Although the mortality rate of the COVID-19 Omicron variants is only approximately half that of previous variants, vaccines effective against Omicron are needed. Demonstrating that a SARS-CoV-2 vaccine can protect against Omicron in an in vivo infection model, particularly in that of Syrian hamsters, is important for the preclinical characterization of SARS-CoV-2 vaccines. Here, we report on the evaluation of W-PreS-O for its ability to protect Syrian hamsters against infection by Omicron. W-PreS-O is a chimeric vaccine based on a single fusion protein (W-PreS-O), combining RBDs from Wuhan hu-1 wild-type and Omicron adsorbed to aluminum hydroxide. The Syrian hamsters were immunized three times at three-week intervals with W-PreS-O or with aluminum hydroxide (placebo), and then they were infected with Omicron BA.1. Non-infected and non-vaccinated animals served as controls. Neutralizing antibody (nAB) titers, weight, lung symptoms (i.e., edema and pneumonia index), and viral loads, as measured using RT-PCR in the upper and lower respiratory tracts, were determined. In addition, infectious virus titers from the lungs were measured using a plaque-forming assay. W-PreS-O-vaccinated hamsters developed robust nABs against Omicron, showed almost no development of pneumonia, and had significantly reduced infectious virus titers in the lungs. Importantly, the viral loads in the nasal cavities of W-PreS-O-vaccinated hamsters were close to or above the PCR cycle threshold considered to be non-infectious. Our data provide compelling evidence demonstrating that the W-PreS-O vaccine has protective effect against Omicron in a Syrian hamster in vivo infection model. W-PreS-O is therefore a highly promising candidate vaccine for Omicron infections, and it should be further evaluated in clinical studies.

The reaction of berberine derivatives containing at O-9 position N,N-disubstituted acetamide fragments with sodium borohydride in methanol at 0 °C leads to a mild reduction of the "C" cycle with the formation of corresponding tetrahydroberberine derivatives with moderate to good yields.

Although ladybirds of European Russia and the Caucasus have been the subject of numerous ecological and faunistic investigations, there is an evident lack of appropriate identification key for them. All previous keys have been published in Russian. The most modern key was published more than 50 years ago and included only about 60 % of species. Guides for identification of Coccinellidae of other countries are not appropriate for European Russia, since do not include many species occurring in the regions. New, original key to subfamilies, genera, and species of ladybirds (Coccinellidae) of the European Russia and Russian Caucasus is presented. All native species recorded in the region and all alien species introduced to this region are included. Some species from the adjacent regions are added. In total, 110 species are keyed and illustrated with line drawings. Photographs of rare and endemic species are provided. Information on the distribution of species within the region under consideration is provided. Synonymy of Chilocorus kuwanae with Ch. renipustulatus is presented and discussed.

The system design for Sustainable manufacturing is to consider both ecological and financial constraints. Manufacturing industry demands to advance in sustainable manufacturing by accounting in environment factors in it. All the factors that affect the environment need to be analyzed so that proper amendments or suggestions can be provided. To favour this, Computer aided life cycle inventory model has been presented for CNC milling and turning processes. Based on utilization of resources and stages, whole machining operation time can be divided into three phases named as process (milling or turning), idle and basic times. As parameters are different for evaluating the process times i.e. depth and width of cut in case of milling and initial and final diameters for turning, two different case studies has been presented one for each milling and turning process. Effect of material choice has been studied for different processes. Highly dense and hard materials takes more time in finishing the job due to low cutting speed and feed rates as compared to that of sot materials. In addition, face milling takes more time and consumes more power as compared to peripheral milling due to more retraction time caused by over travel distance and lower vertical transverse speeds than the horizontal transverse speed used in peripheral retraction process.

The research is devoted to the problem of noise generation during flights of supersonic civil aircrafts. The effect of a thermally stratified energy source used to control the flow past a pointed cylinder aerodynamic models on the nearfield and ground pressure signatures, as well as on the perceived loudness in decibels (PLdB) on the ground is evaluated. The fields of parameters and the dynamics of the drag forces are studied for different values of temperature in the layers of the thermally stratified energy source and for different number of layers in it. It has been shown that when performing the flow control at freestream Mach numbers 1.5-2 using thermally stratified energy sources with the number of layers from 2.5 to 7.5 and rarefaction parameters in the layers from 0.15 to 0.3, no additional noise impact on the ground is introduced. Thus, the simulations showed that changing the surface pressure signature due to drag reduction does not necessarily imply a change in the PLdB on the ground.

The IPAT equation provides a simple but powerful model for understanding sustainability, particularly from the challenge posed by the Anthropocene—how to reduce personal or societal impact. Impact is calculated by multiplying population, affluence and technology, and a ‘reduction coefficient’ e is used to explore targeted reductions in impact of different entities to cap total (summed) impact. The model offers two solutions. First, that all three factors are essential in determining total impact; a focus on just one or two is not justifiable without credibly addressing the other(s). Second, by presenting reduction of impact as a proportion of current activity, the solution becomes accessible to an individual actor (e.g., an individual, family, organization, or country). Application of the model is illustrated based on household weekly food consumption from cultures around the world. The model helps unify a) disparate perspectives on population, affluence and technology, which currently oppose one another from a basis of belief or dogma, and b) different sectors (e.g., food production, energy, climate impacts and others), as well as actors, so they can jointly identify strategies to resolve their contributions to approaching larger scale sustainability.

This paper gives an overview of the large-scale tectonic styles encountered in orogens worldwide. Thin-skinned and thick-skinned tectonics represent two end member styles recognized in mountain ranges. Both styles are encountered in former passive margins of continental plates. Thick-skinned style including the entire crust and possibly the lithospheric mantle are associated with intracontinental contraction. Delamination of subducting continental crust and horizontal protrusion of upper plate crust into the opening gap occurs in the terminal stage of continent-continent collision. Continental crust thinned prior to contraction is likely to develop relatively thin thrust sheets of crystalline basement. A true thin-skinned type requires a detachment layer of sufficient thickness. Thickness of the décollement layer as well as the mechanical contrast between décollement layer and detached cover control the style of folding and thrusting within the detached cover units. In subduction-related orogens, thin- and thick-skinned deformation may occur several hundreds of kilometers from the plate contact zone. Basin inversion resulting from horizontal contraction may lead to the formation of basement uplifts by the combined reactivation of pre-existing normal faults and initiation of new reverse faults. In most orogens thick-skinned and thin-skinned structures both occur and evolve with a pattern where nappe stacking propagates outward and downward

Pain is a natural bioassay for detecting and quantifying biological activities of venoms. The painfulness of stings delivered by ants, wasps, and bees can be easily measured in the field or lab using the stinging insect pain scale that rates the pain intensity from 1 to 4, with 1 being minor pain, and 4 being extreme, debilitating, excruciating pain. The painfulness of stings of 96 species of stinging insects and the lethalities of the venoms of 90 species was determined and utilized for pinpointing future promising directions for investigating venoms having pharmaceutically active principles that could benefit humanity. The findings suggest several under- or unexplored insect venoms worthy of future investigations, including: those that have exceedingly painful venoms, yet with extremely low lethality – tarantula hawk wasps (Pepsis) and velvet ants (Mutillidae); those that have extremely lethal venoms, yet induce very little pain – the ants, Daceton and Tetraponera; and those that have venomous stings and are both painful and lethal – the ants Pogonomyrmex, Paraponera, Myrmecia, Neoponera, and the social wasps Synoeca, Agelaia, and Brachygastra. Taken together, and separately, sting pain and venom lethality point to promising directions for mining of pharmaceutically active components derived from insect venoms.

Pollution, urbanization and technological advancements have posed stress on the ecosystem and its matrices. Globally, pollutants are observed in all compartments of ecological communities which affect the integrity of the atmosphere, hydrosphere, lithosphere and biosphere. Xenobiotics bioaccumulate and biomagnify across trophic levels or webs. Heavy metals have been implicated in impacts towards biodiversity and environmental declination. In Nigeria, wastes issues are a cause of concern and landfilling or are waste disposal approaches that cause deleterious effects such as depauperation of diversity and species decline, prompting the non-invasive ecotoxicological hazard assessments. Feathers were used to assess concentration levels of 13 metals (Fe, Mn, Zn, Cu, Co, Cr, Cd, Pb, Ni, Al, B, Se and Hg) using fast atomic absorption spectrophotometer (FAAS), one-way ANOVA was used in comparing variations in mean concentrations across trophic levels, diversity indices and point count methods were used to estimate diversity and abundance. Four avian species were assessed Hirundo aethiopica (insectivore), Streptoptelia senegalensis (granivore), Turdus pelios (omnivore), and Anthus leucophrys. (insectivore). Observed concentrations of important metals like iron were high with the insectivores having the highest concentrations of iron (2.6985 ± 0.1975 ppm) and granivores having the lowest (2.0100 ± 0.3172 ppm). The insectivores had the highest concentrations for cadmium, cobalt and chromium (0.0005 ± 0.0005ppm), nickel (at 00.0012 ± 0.0017 ppm) and least was observed in the granivores (0.0003 ± 0.0006 ppm). Selenium concentrations were quite high in insectivores (0.0775 ± 0.0035 ppm) and lowest in granivores (0.0433 ± 0.0015 ppm) likewise mercury for insectivores (0.0280 ± 0.0010 ppm) and granivores (0.0213 ± 0.0015 ppm). From the study, it is apparent that landfills are sources of pollution and poor management of wastes can affect biota (causing effects such as asymmetry and bioaccumulation) and ecosystem balance. The observation of heavy metals in the feathers serve as good sentinels due to their trophic levels and could be signs for what could be yet to occur. The heavy metal concentrations were significantly different at p < 0.05.

Relying on the USA, Canada and Mexico extract from the cross-national data sample on the environmental affection and cognition of adolescent students (Niankara, 2019), along with seemingly unrelated bivariate weighted ordered probit regression modeling (Niankara and Zoungrana, 2018), this study reports on the convergence of technological awareness and expectations within the context of international trade. We achieve this by adopting a regional perspective in investigating the effects of affective, cognitive and situational factors on youth's awareness and expectations about genetically modified organisms (GMOs) and nuclear power technology (NPT) within the North American free trade block. Identification of model parameters is achieved using maximum simulated likelihood methods. The findings show that although it has been over 20 years as of 2015 that USA, Canada, and Mexico ratified the north American free trade agreement (NAFTA), the diffusion of technology and information within the trade block has not succeeded in homogenizing awareness and expectations about GMOs and Nuclear power technology, as observed in the youth population across the three countries. Indeed, with regards to technological awareness, compared to youth from the USA, those from Canada show 15% (GMOs) and 7.1% (NPT) more awareness respectively; while those in Mexico are respectively 34.4% and 19.5% less aware about GMOs and NPT. With respect to technological expectations, compared to youth from the USA, those from Canada and Mexico are respectively 34.4% and 39.9% more optimistic about GMOs, while 15% and 49.7% more optimistic about NPT. Overall, youth within NAFTA country members are respectively 2.5% and 6.7% more optimistic about GMOs and NPT for every level increase in their awareness about the two technologies.

This paper highlights the impact of financial inclusion on individuals’ borrowing and saving decisions in the United States and the United Arab Emirates. It does so, using data from the 2014 Global Financial Inclusion database, and an empirical strategy consisting of first testing the significance of the joint bivariate model over its binary conterparts using the Lagrange multiplier test, followed by a contrast between the fully-parametric and semi-parametric specifications of the saving and borrowing equations. Based on model performance measures, the semi-parametric bivariate probit specification is identified as a better framework for describing the two processes of saving and borrowing, with a correlation coefficient of 12.3%. Although no significant difference exists between UAE and US residents in borrowing behavior, we find that US residents are 31.4% more likely to save than their UAE counterparts. In addition, and in line with the Permanent Income Hypothesis, the results reveal the absence of an income based saving or borrowing gradient in the two countries. Conversely, we found the prevalence of a gender based saving (12.4%) and borrowing (13.8%) inequality in favor of the male gender. Furthermore, access to a bank account and a debit card, companies policy of direct wage and salary transfer, and government transfer programs with direct deposit options are all financial inclusion strategies that are found to significantly raise the likelihood of saving and borrowing. As such, companies with payroll practices based on cash or physical paycheck issuing, especially in the US, should revise such policy to create more financial inclusion, and thereby more saving potential which in turn would contribute to further borrowing, investment and growth of the national economy.

Cheap licit and artisanal illicit spirit drinks have been associated with numerous outbreaks of alcohol poisoning especially with methanol. This study aimed to evaluate the quality of cheap spirit drinks in Kibera slums in Nairobi County, Kenya. The samples consisted of cheap licit spirits (n=11) and the artisanal spirit drink, ‘chang’aa’, (n=28). The parameters of alcoholic strength and volatile composition were used as indicators of quality and were determined using GC-FID and GC-MS respectively. The pH of chang’aa was 3.3-4.2 and 4.4-8.8 for licit spirit drinks while ranges for alcoholic strength were 42.8-85.8 % vol. and 28.3-56.7% vol. for chang’aa and licit spirit drinks respectively. The majority of volatiles were found in artisanal spirits and they included higher alcohols, ethyl esters and carbonyl compounds. The alcoholic strength of all the artisanal spirits (100%) and 91% of the licit spirits was above the 40% vol. of standard spirits such as vodka. The high ethanol content of the alcohol products was the only element of public health significance in this study.

Gasca D herbal formulation is an antidiabetic medicine for the management of diabetes mellitus produced exclusively from natural ingredients. The level of some essential elements (Copper, chromium, Cobalt, Iron, Manganese, Nickel and zinc) and toxic (Cadmium, Arsenic, Mercury, and Lead) heavy metals were determined using microwave plasma-atomic emission spectrometry (MP-AES). The aim of this study is to evaluate the levels of essential and toxic heavy metals and also identify bioactive compounds present in Gasca D herbal formulation. The result shows no traces of Lead, Mercury, Zinc, Arsenic and Zinc, Iron was found to have highest concentration 67.16 + 7.5 µg/g and Cadmium lowest concentration 0.4 + 0.03µg/g. GC-MS analysis of Gasca D herbal formulation revealed the presence of 14 biologically active compounds which include N-Formyl-beta-alanine, Paromomycin, 3,4-Altrosan, Benzamide, 1,3,4-Thiadiazol-2-amine, Carbamodithioic acid, Carbonic acid, alpha-D-Glucopyranoside, Ethyl isocyanide, 2-Propanesulfinic acid, Propanamide, 2-Butenenitrile, Dicyclopropyl carbinol, Isoxazolidine, 1,5-Hexadiene 10-Azido-1-decanethiol. Conclusion: The result indicates that the mean levels of toxic metals in Gasca D herbal formulation were below WHO permissible levels. Gasca D herbal formulation also contains various bioactive compounds that can have various medicinal application which can be used for the treatment of various diseases.

Microalgae have emerged as potential feed stock for third generation biofuel and other bioactive compounds. In the present investigation we have evaluated the two native strains of Oscillatoria (O. subbrevis MTC-20702 and O. sancta MTC-20703) isolated from two different fresh water biotopes of Meerut, U.P., India and were subjected for the characterization of generation time, biomass, bio-molecules including Chlorophyll-a, carotenoids, carbohydrate, lipids, phycobilins and proteins. Both strains of Oscillatoria were grown in batch culture till the initiation of declining phase and were harvested on every 10th day of incubation till the starting of declining phase. Result of the present investigation revealed that O. subbrevis MTC-20702 can be potentially exploited for the production of high algal biomass, feed stock for biofuel, Chl-a, carotenoids, c-Allophycocyanin and maximum yield of these bioactive compounds can be achieved on 20th day. However, O. santa could be very good source for c-Phyocyanin, c-Phycoerythrin, carbohydrate and protein and these also can be achieved highest on 20th day of incubation. In addition, as these two strains were isolated from water reservoirs and they can be cultivated in large scale for the production of desired bio-molecules.

A proof is given showing the Collatz Conjecture is true for all positive integers. The proof was possible once the perspective of the proof was changed from looking at the pattern of the positive integers to looking at the conjecture rules. The conjecture rule for even numbers organizes all positive integers into unique sets and the rule for odd numbers interconnects the unique sets into dendritic pathways to “1.” Infinite loops, other than the minor 4-2-1 loop after reaching “1,” and pathways to infinity are shown to be mathematically impossible. The proof predicted a general equation that shows all positive integers ultimately reach a final value of “1," and calculates the values and locations of the odd positive integers during the iterations for each tested positive integer.

Introduction: In the recent years alternate day dosing has been recommended in iron deficieny treatment. The aim of this study is to compare the efficacy and side effects of oral iron treatments given daily 1x1, alternate day 1x1 and 2x1 alternate day dosing in iron deficieny anemia patients. Methods: A total of 52 patients with a diagnosis of iron deficiency anemia with serum ferritin level of 25 µg/L or less were included in this retrospective study. Statistical analyzes were done with SPSS V.25. Results: The patients included in our study were between the ages of 18-51. All of the patients included in the study were female. A statistically significant increase was found between 0-14 days(p<0.001), 14-28 days(p<0.001) and 0-28 days(p<0.001) hemoglobin values in all patients. There was no statistically significant difference between 0-14 days (p=0.397) and 0-28 days(p=0.310) ferritin values in all patients. A statistically significant difference was found between 14-28 days(p<0.001) ferritin values. When the rate of change of hemoglobin and ferritin values between the groups was compared and no statistically significant difference was observed between the groups. The rate of change of ferritin values for 14-28 days was significant (p=0.012). There was no significant difference in the frequency of symptoms in the 14th day and 28th day controls for each group (p>0.05). The incidence of metallic taste and bloating symptoms was found to be statistically significant in the third control in the group with 2x1 drug use alternate day (p=0.094). Discussion: The only difference in efficacy was observed in ferritin values between 14th and 28th days. The increase in ferritin values was higher in the group that used 1x1 oral iron every day. However, since no difference was observed between the groups in terms of ferritin and hemoglobin values on days 0 and 28, all three groups were considered equally efficient. Side effects were mainly gastrointestinal side effects. Since the group that received 2x1 oral treatment alternate day had a statistically significantly higher rate of side effects, the patients’ treatment tolerance will be lower compared to the other groups. In conlusion, there is no difference in efficacy and side effects between the patient groups receiving 1x1 daily and 1x1 alternate day oral iron therapy, so 1x1 use alternate day is the most appropriate treatment method for oral iron therapy in terms of patient tolerance, adherence to treatment and pharmacoeconomics.

Background: Twitter is a major tool for communication in emergencies such as natural disasters. This online social network allows the user to produce content, and it is not designed exclusively for news releases, as opposed to other service providers. Aim: The aim of this study is to investigate Twitter uses in natural disasters and pandemics. Methods: The included studies reported the role of Twitter in natural disasters. The studies that report in settings other than the natural disasters (such as man-made disasters) and other social media were excluded. Electronic databases for a comprehensive literature search including MEDLINE, Web of Science, CINAHL, PsycINFO, Cochrane Register of Controlled Trials (CENTRAL) and EMBASE were used to identify the records that match the mentioned inclusion criteria published till May 2020. The study characteristics were extracted from the qualified studies including year of publication, findings, and geographical location of the study conduct. A narrative synthesis for this literature review was used. Results: The search identified 822 articles of which 780 articles were removed, 256 were not available, 311 papers were not relevant, 16 were duplicated articles, and 197 were non-related to the emergencies. 45 articles met the selection criteria and were included in the review. eleven themes were found in the narrative synthesis including early warning, disseminating information and misinformation, advocacy, personal gains, assessment, various roles of organizations, public mood, geographical analysis, charity, using influencers, and trust. Conclusions: It is recommended that influential individuals be identified in each country and community before disasters occur so that the necessary information can be disseminated in response to disasters. Preventing the spread of misinformation is one of the most important issues in times of disaster, especially pandemics. Disseminating accurate, transparent, and prompt information from relief organizations and governments can help. Also, analyzing Twitter data can be a good source for understanding the mental state of the community, estimating the number of injured people, estimating the points affected by natural disasters, and modeling the prevalence of epidemics. Therefore, various groups such as politicians, the government, non-governmental organizations, aid workers, and the health system can use this information to plan and implement interventions.

This study inscribes itself in the global discussion on the nurturing of pro-environmental behaviors among young people for a sustainable future. Here we focus on students' interest in Ecosystem Services and Sustainability to explain their awareness and optimism about the environmental issues of air pollution, water shortage and green gas emission in 50 countries around the world. To this end, we use the cross-sectional survey data of the OECD's Program for International Student Assessment (PISA) 2015, along with seemingly unrelated bi-variate weighted ordered Probit modeling with country specific effects. The results show that in addition to factors such as age, gender, immigration status, and economic, social and cultural status, interest in the biosphere is a significant determinant of students' environmental awareness and optimism. In fact, a one level increase in students' interest in ecosystem services and sustainability raises on average their awareness level by 15.3% for the issue of air pollution, 15.7% for the issue of water shortage, and 24.6% for the issue of green gas emission. Although students' interest in the biosphere seems to not have a significant effect on their expectations about the issue of green gas emission, it does however raise their level of optimism by 0.8% for the issue of air pollution, and 0.2% for the issue of water shortage. Furthermore, every one level increase in students' environmental awareness leads to 17.3% more optimism about the issue of air pollution, 15.8% more optimism about the issue of water shortage, and 17.4% more optimism about the issue of green gas emission. Therefore, relying on the Theory of Planned Behavior (TPB), our results imply that governments and policy makers can successfully leverage young people interests in the biosphere to effectively achieve their goals for sustainability.

By using the Sala-i-Martin version of extreme bounds analysis, which is based on the cumulative density function, cross-sectional evidence is presented on the robust determinants of the infection and case mortality rates of Covid-19. The results show that, for most part, different factors determine the infection and mortality rates in developed and developing countries. However, common factors are also apparent, including the risk environment, the number of tests per million and the percentage of population over 65. Notwithstanding the possibility that the official data represent a partial reflection of the truth, it is concluded that the results presented in this study provide useful information that may aid decision-making in the fight against the pandemic.

Along with the advantages associated with access to information and fast communication, screen time from increased digital media consumption has recently been associated with adverse effects on youth well-being. To get a clearer picture of its value for global youth based sustainability initiatives, this study investigates the effects of increased digital media consumption on youth's interests in ecosystem services, sustainability and science as a means for disease prevention. We achieve this, using data on 187821 adolescent students from 50 countries worldwide. Methodologically, we rely on a mixed bivariate ordered probit representation of youth's joint interest in the biosphere (ecosystem services and sustainability) and science as a means for disease prevention, which we then estimate using Markov Chain Monte Carlo (MCMC) Methods. We found that each level increase in adolescent students' reported frequency of news blogs visits and web browsing on broad science adversely affect their interests in ecosystem services, sustainability and science as a means for disease prevention. Although each level increase in youth's frequency of ecological website visits also reduces by 20% (with 95% CI [-0.36; -0.32]) their interests in the biosphere, it is found to increase however by 3% (with 95% CI [0.02; 0.05]) their interest science as a means for disease prevention. Overall, our results highlight heterogeneous effects of digital media consumption on adolescents' well-being in terms of their interests in ecosystem services, sustainability, and science as a means for disease prevention.

The prevalence of corona virus and the novel COVID-19 disease in the entire globe has exacerbated different impact on socioeconomic spectrum in the world, including water use pattern. Thus a research was conducted to examine the comparative use of water during pre- and post-COVID-19 lockdown pattern among post-primary schools in Iwo, Osun State, Nigeria. A survey was conducted among fifteen schools which were randomly selected, but with eight public and seven private schools for the investigation. Both descriptive and inferential statistical techniques were used in data analysis. The results revealed that the major source of water to the schools investigated is ground water which is obtained through hand-dug wells and boreholes. It was further discovered that there was increase in water use during post-COVID-19 lockdown era as a result of the directive by the government that clean water should be provided for hand-washing by all schools regardless of the owner to curtail the spread of COVID-19 disease in the country. One sample t-test also revealed that there was a significant difference in water use at (p<0.01) level. It is recommended that the government and other stakeholders in water sector to ensure that all-time and non-seasonal dependent source of water be provided rather than ground water source which is susceptible to variations in water yields from seasonal variations. This will enable continuous clean water supply, for all purposes, including COVID-19 protocols.

A single paragraph of about 200 words maximum. For research articles, abstracts should give a pertinent overview of the work. We strongly encourage authors to use the following style of structured abstracts, but without headings: (1) Background: Place the question addressed in a broad context and highlight the purpose of the study; (2) Methods: briefly describe the main methods or treatments applied; (3) Results: summarize the article’s main findings; (4) Conclusions: indicate the main conclusions or interpretations. The abstract should be an objective representation of the article and it must not contain results that are not presented and substantiated in the main text and should not exaggerate the main conclusions. This study presents a comprehensive literature review on the convergence of affective computing, interactive installation art, multi-dimensional sensory stimulation, and artificial intelligence (AI) in measuring emotional responses. It addresses the problem of understanding emotional response and measurement in the context of interactive installation art under artificial intelligence (AI). The study aims to fill the existing research gaps by examining three key aspects: sensory stimulation, multi-dimensional interactions, and engagement, which have been identified as significant contributors to profound emotional responses in interactive installation art. The study proposed approach involves conducting a process analysis of emotional responses to interactive installation art, aiming to develop a conceptual framework that explores the variables influencing emotional responses. The study will formulate hypotheses that make specific predictions about the relationships between sensory stimulation, multi-dimensional interactions, engagement, and emotional responses. By employing the ASSURE model combined with experimental design, the research methodology ensures a systematic and comprehensive study implementation. The implications of this project lie in advancing the understanding of emotional experiences in interactive installation art under AI, providing insights into the underlying mechanisms that drive these experiences. The contributions of this research include bridging the identified research gaps, refining theoretical frameworks, and guiding the design of more impactful and emotionally resonant interactive artworks. Ultimately, this research aims to contribute to the broader field of human-computer interaction and enhance the development of immersive and emotionally engaging interactive installations.

The stick-free flight stability is an old-fashioned and non-progressive issue; nevertheless, it is still existent, and of significant importance to the design of aircraft whose control system is reversible. The problem’s existence necessitates a deep assessment of stick-free flight stability throughout the aircraft design. Up to now, this problem has been addressed using either analytical approaches, which are only related to the static stability evaluation, or performing flight tests. In this study, the problem is handled in its entirety, from static and dynamic flight stability assessment to design criteria with a comprehensive perspective. Moreover, it is also exhibited that contrary to what has been generally proposed in the literature, limiting the problem of stick-free flight stability through static stability assessment is far from the main challenge. As a brief scope, the derivation of the control surface dynamics, a stick-free trim algorithm, and assessment rationale of the stick-free static and dynamic flight stability using a simulation approach are proposed. As a consequence, the aim is to set a broad understanding for designers related to this phenomenon and add adjunct design criteria in the design optimization process by approaching it in terms of modeling, simulation, and flight test perspective.

Sachet water (SW) is a major source of drinking water in most Nigerian homes, thus making it a possible conveyance medium for health risks due to contamination rather than for replenishment of the body. This study collected SW from three busy neighborhoods and investigated for the presence of indicator bacteria – Escherichia coli (E. coli), Total Coliform (TC), Total Heterophilic Bacteria (THB), and Staphylococcus – and some physio-chemical parameters – total dissolved solids (TDS), pH, electrical conductivity (EC), and salinity. Multi-variable and exploratory statistical methods were applied to the results to determine correlations between bacterial contamination levels and perceived brand reputation. Bacteriological test with raw SW samples appeared too numerous to count (TNC) and thus required serial dilutions. After seven dilutions, results obtained revealed that SW brands with good reputation had no TC and E. coli and was statistically significant with groupings of other SW brands (χ2 = 12.28; p < 0.05 and χ2 = 37.96; p < 0.05) respectively. Additionally, SW brands with poor reputation had mean values of TC (19.7X10^8 cfu/ml;14X10^8 cfu/ml1.15X10^8 cfu/ml) and E.coli (18.2X10^8 cfu/ml;38.7X10^8 cfu/ml,32.4X10^8 cfu/ml) exceeding threshold value of zero set by the World Health Organization (WHO). Only one sample from poor reputation brand tested positive for Staphylococcus and was not statistically significant (χ2 =5.2191; p = 0.074). Principal Component Analysis (PCA)/ Factor Analysis (FA) revealed that most of the SW had fecal contamination in an alarming magnitude. Therefore, this study suggests that periodic cleaning of distribution lines, location specific treatment, QC and QA measures should be taken to reduce water security risk for SW consumption in the region.

Background: Exclusive breastfeeding (EBF) for the first 6 months of life improves the growth, health and survival status of newborns. Breastfeeding has been accepted as the most vital intervention for reducing infant mortality and ensuring optimal growth and development of children. Objectives: The general objective was to identify the factors affecting exclusive breastfeeding among working class women in selected wards in Egbedore Local Government in Osun state, Nigeria. Methodology: This was descriptive cross-sectional study. Leslie Kish formula was used for sample size calculation and multistage sampling was used in selecting 316 working class women for the study. A structured, self-administered questionnaire was used for data collection. Data was analyzed using SPSS version 21.0 and level of significance was set at 5%. Results: 58% of the respondents were between the ages of 25-30. 72% demonstrated good understanding of exclusive breastfeeding based on the 6 months WHO recommendation for exclusive breast feeding, 25.9% had a fair knowledge and awareness of exclusive breastfeeding. 63.3% of the working class mother has a good practice of exclusive breast feeding, 19.6% of the women moderately practices exclusive breastfeeding while 17.1% poorly practices exclusive breastfeeding. Less than 3-months maternity leave for mothers, lack of crèche closer to place of work and lack of breastfeeding break were identified as barriers to exclusive breastfeeding practices among the working class women. The findings demonstrated a significant relationship between knowledge and practices of exclusively breastfeeding among working class women (P-value .009). Conclusion: This study demonstrated that working class women had good knowledge of exclusive breastfeeding and this influenced their breastfeeding practices. A good knowledge was associated with favorable attitudes to the practice of exclusive breast feeding. To derive long-term benefits from early childhood nutrition, interventions should focus on health education and community-based sensitization programs on the needs for mothers to engage in exclusive breast needing for global development.

Since the energy sector is the main source of greenhouse gases, it has the highest potential for improvement. Improvements can be achieved by generating energy from renewable sources. Combined with thermal energy storage, concentrating solar power plants represent a promising technology for dispatchable renewable energy, ensuring a stable energy supply even in remote areas without contributing to greenhouse gas emissions during operation. However, it is important to note that greenhouse gases and other polluting emissions may occur during the manufacturing process of concentrating solar power plant components. This work analyses the design of the receiver to produce thermal energy for the existing solar dish CSP plant at the Energy Center of the Politecnico di Torino. The objective of this plant is to produce hot water for a small case study. Considering the average solar irradiance for Turin equal to 800 W/m2, the surface heat flux was obtained from the first part of the analysis, which was used to obtain the maximum internal temperature in the receiver equal to 873.7 °C. The maximum temperature obtained was a constraint for the selection of the material for the solar receiver. Of the various possibilities, copper was chosen. In the second part of the work, a Life Cycle Assessment was carried out to compare the emissions generated during the production of the main components of the CSP plant with the emissions generated by the methane-fuelled water heater that produces the same amount of water as the CSP plant. It can be concluded that the manufacture of the main components of the CSP plant results in lower greenhouse gas emissions than the operational phase of a conventional natural gas-fired water heater (1.6 kg CO2/day).

Water resources worldwide are limited, especially in desert areas like Saudi Arabia. Therefore, the rational and sustainable management of irrigation water supply is an imperative required by the conditions of space and time. This study evaluates the irrigation system through partial root-zone drying (PRD) and regulated deficit irrigation (RDI). The effect of applying the PRD and RDI systems on the efficiency and rationalization of irrigation water consumption in a greenhouse and open field cucumber was studied in addition to using the surface (S) and subsurface (SB) drip irrigation methods on irrigation efficiency. The productivity of the RDI-S regular drip irrigation treatment was considered 100% as the control on which the results of all treatments are measured. The results showed that in terms of irrigation technique, the PRD-SB technique had the highest productivity during the winter season in greenhouse cucumbers, with a general average of 13.8 kg m-2 for all irrigation levels, while the RDI-SB technique had the highest productivity during the summer season, with a general average of 16.1 kg m-2. Regarding irrigation level results, the study showed that an irrigation level of 100% is the highest productivity in all irrigation techniques, with a general average of 14.9 kg m-2 for all irrigation techniques during the winter season and 16.4 kg m-2 during the summer. However, the increase in the irrigation level to 150% did not increase productivity. In comparison, the application of the deficit irrigation technique by reducing the level of irrigation to 50% was not accompanied by a similar decrease in productivity. The study results also showed that irrigation with the PRD-SB system was the most productive in the open field at all irrigation levels, with a general average of 7.3 kg m-2. The general average of the percentage decrease in productivity in all irrigation techniques compared to reducing the irrigation percentage to 50% and 75% was 22% and 3 %. The irrigation efficiencies were higher when applying the PRD (PRD-SB) in winter. In contrast, applying a deficit irrigation system (RDI-SB) in the summer season had the highest efficiency. It could be concluded that using PRD and RDI systems for indoor and outdoor cucumber can save irrigation water.

Membrane-based sensors (MePSs) exhibit remarkable precision and sensitivity in detecting pressure changes. MePSs are commonly used to monitor catalytic reactions in solution, generating gas products crucial for signal amplification in bioassays. They also allow catalyst quantification by indirectly measuring the pressure generated by the gaseous products. This is particularly interesting to detect enzymes in biofluids associated with disease onset. To enhance the performance of a MePS, various structural factors influence membrane flexibility and response time, ultimately dictating the device's pressure sensitivity. In this study, we fabricated MePSs using polydimethylsiloxane (PDMS) and investigated how structural modifications affect the Young's modulus (E) and residual stress (σ0) of the membranes. These modifications have a direct impact on the sensors' sensitivity to pressure variations, observed as a function of the volume of the chamber (Σ) or of the mechanical properties of the membrane itself (S). MePSs exhibiting the highest sensitivities were then employed to detect catalyst quantities inducing the dismutation of hydrogen peroxide, producing dioxygen as gaseous product. As a result, catalase enzyme was successfully detected using these optimized MePSs, achieving a remarkable sensitivity of (22.7 ± 1.2) µm/nM and a limit of detection (LoD) of 396 pM.

Motivated by the theoretical model of health insurance choice with Flexible Spending Accounts (FSAs) presented in Cardon 2012, this study investigates the determinants of optional coverage (SSP) and flexible spending accounts (FSA) enrollment, among the privately insured in post-affordable-care-act (ACA) USA. To this end, we rely on semi-parametric bi-variate probit methods, along with a pooled cross-section of the 2015-2016 National Health Interview Surveys. As predicted by the theoretical model, we find that SSP and FSA are complement health solutions with a positive correlation. Our results emphasize that the most important trigger factors influencing the joint probability of SSP and FSA adoption include not only insurance premium cost, but also age, education, marital status, number of work hours, region of residency, citizenship status, and annual health expenditure level. We find that controlling for these latter factors, health status is not significant especially for FSA adoption. In addition, despite the fact that the relative frequency of individuals with FSA rises with increasing levels of medical expenditure, ACA restrictions on FSA tax exclusion to an annual adjusted maximum of $2600 (in 2017 $s) seems to adversely burden individuals with greater medical expenditure, thereby reducing their likelihood of FSA enrollment in post-ACA USA. Understanding these factors is very crucial to US health care market's stakeholders, including insurance companies, firms looking to design their health insurance offerings, but also policy-makers interested in providing new tailored health solutions for reducing health risks.

Knowledge is not merely the characteristic of certain pieces of information being deemed true and justifiable, but rather a process. Within an axiomatic system, the set of information that reaches the status of knowledge forms a universe that provides an interpretation of the reality one aims to describe. Language exchanges information through communication and the process of justification (exchange of information), if it consistently justifies a particular piece of information, it elevates it to knowledge. In this paper, we provide a framework for knowledge within an axiomatic model where we define the fundamental elements of communication and grammar. As a result, the structure dictates that knowledge, to be considered as such, must be investigateable by anyone who utilizes it in its entirety, both in form and content. Ultimately, the development of knowledge processing, referred to as \emph{knowmatics}, represents a clear evolution of the computer science that processes information (subset of knowledge).

Maize is an important staple food crop in sub-Saharan Africa (SSA). However, the average grain yield on farmers’ fields falls considerably short of the demand of the region’s population. In addition, the normal endosperm maize widely consumed in SSA is deficient in vitamin A. Drought, a consequence of climate change, is a major constraint to maize production, resulting in seasonal low grain yield in farmers’ fields. The objectives of this study were to assess the performance of newly developed extra-early maturing provitamin A hybrids under managed drought and well-watered conditions, compare the outcomes of multiple trait base-index and multi-trait genotype-ideotype distance index selection procedures, and identify drought-tolerant hybrids with stable performance across contrasting environments for commercialization in SSA. One hundred and ninety provitamin A hybrids and six checks were evaluated under managed drought and well-watered conditions at Ikenne for two seasons between 2021 and 2023. A 14*14-lattice design was used for the field evaluations under both research conditions. Drought stress was achieved by the complete withdrawal of irrigation water 25 days after planting. Results revealed significant differences among the hybrids under drought and well-watered conditions. Grain yield, ears per plant, and plant aspect under managed drought were correlated to the same traits under well-watered conditions suggesting that the expression of these traits is governed by common genetic factors. Twenty-nine hybrids were identified as top-performing drought-tolerant hybrids by the multiple trait base index and multiple-trait genotype–ideotype distance index. Of the selected outstanding 29 hybrids, 34% were derived from crosses involving the tester TZEEIOR 197, demonstrating the outstanding genetic potential of this inbred line. Further analysis of the 29 selected hybrids revealed TZEEIOR 509 × TZEEIOR 197 as the hybrid that combined the most drought-tolerant adaptive traits. However, the hybrids TZEEIOR 526 × TZEEIOR 97, TZEEIOR 384 × TZEEIOR 30, TZEEIOR 515 × TZEEIOR 249, TZEEIOR 510 × TZEEIOR 197, TZEEIOR 479 × TZEEIOR 197, and TZEEIOR 458 × TZEEIOR 197 were identified as the most stable hybrids across drought and well-watered conditions. These hybrids should be extensively tested in multi-location trials for deployment and commercialization in SSA.

Coal currently accounts for over 38% of electric power generation around the globe. Hence, it is a significant critical contributor to socio-economic growth and development, particularly in the BRIC economies. The success of the coal energy in these nations in addition to the discovery of vast new coal deposits have revived Nigeria’s interest in coal power. However, there is lack of comprehensive data on the pollution emission profiles, along with the physicochemical, thermal, and kinetic properties of Nigerian coals as required for power plant operations. Therefore, this paper presents preliminary findings on the physicochemical, microstructural, mineralogical and thermal properties of Owukpa (WKP) coal from Benue State in Nigeria. The results showed that WKP contains high compositions of combustible elements and heating value but low pollutant elements. Furthermore, thermal degradation revealed high conversion efficiencies particularly under oxidative conditions as required for electric power generation through combustion.

The conformations of trifluoroacetyl triflate, CF3C(O)OSO2CF3, were investigated through vibrational experimental methods (gas-phase FTIR, liquid-phase Raman, and Ar-matrix FTIR spectroscopy) and Density Functional Theory (DFT) calculations. A potential energy surface was computed using the B3P86 /6-31+g(d) approximation as a function of the dihedral angles τ1 = CCOS and τ2 = COSC. The surface reveals three minima, which were further optimized using the B3LYP method with various basis sets (6-31++G(d), 6-311++G(d), tzvp and cc-pvtz). The global minimum corresponds to a syn-anti conformer (the CO double bound syn with respect the O−S single bond and the C−O single bond anti with respect to de S−C single bond). The other two minima represent enantiomeric syn-gauche forms. The Ar-matrix FTIR spectrum exhibited clear evidence of the presence of two conformers. Furthermore, the randomization process observed following broad-band UV-visible irradiation facilitated the identification of the IR absorption of each conformer. Based on the Ar-matrix FTIR experiments, the vapour phase of trifluoroacetyl triflate at room temperatures was composed of approximately 60-70% of the syn-anti conformer and 30-40% of the syn-gauche form.

The chelating aluminum complex [2-(Me2NCH2)C2B10H10]AlX2 (X = Br 3, CH3 4) was synthesized using 2-dimethylaminomethyl-o-carboranyl lithium (2) with aluminum tribromide or dimethylaluminum bromide, resulting in a modest yield. Compound 4 was obtained by reacting compound 3 with CH3Li in toluene. All compounds were characterized by infrared (IR) spectroscopy, 1H, 11B, 13C nuclear magnetic resonance (NMR) spectroscopy, and X-ray crystallography. X-ray structural studies of CabNAlBr2 (3) and CabNAlMe2 (4) indicated that the Al atom was located at the center of a distorted tetrahedron. Crystal structures of the CabNAlBr2 (3) [a = 8.9360(3) Å, b = 12.0358(9) Å, c = 14.7730(4) Å, α = β = γ = 90°] and the CabNAlMe2 (4) [a = 8.9551(3) Å, b = 11.9126(9) Å, c = 14.7711(4) Å, α = β = γ = 90°] were obtained. The reactivity of aluminum complexes 3 and 4 with Lewis bases, such as H2O, pyridine, alkylamines, and arylamines, confirmed their rapid decomposition.

The paper deals with the problem of choosing the best O&M strategy for wind power plants. Current maintenance theory considers just production opportunities and minimizes the maintenance costs, but with the liberalization of the electricity market also the electricity price has become an important variable to take into account in the O&M scheduling. Another important variables that is often neglected by the existing maintenance theory is the weather condition. This paper proposes a new strategy that takes into account the electricity price and weather conditions, improves the expected profit of the systems, and reduce the overall maintenance and logistic costs. The maintenance schedule is formalized as an optimization problem where the discounted cumulative profit of a wind generation portfolio in a fixed-time horizon (e.g. two years ahead), subject to the technologically-derived maintenance time constraints is optimized. Both the theoretical and computational aspects of the proposed O&M strategy are discussed. Results show that taking into account market and weather opportunities in the design of the maintenance strategy, it is possible to achieve a more complete scheduling for a given set of wind power plants.

This paper relies on accounting-based measures of country risk to investigate U.S. global banks' exposure to foreign country risk over the 2017 fiscal year as measured by the sum of cross-border risk, foreign office risk, and derivative risk claims. We achieve this using panel linear modeling methods with country level heterogeneity and time fixed effects, along with a constructed panel data of 284 observations on 71 countries distributed across 6 world regional blocks, and observed over 4 consecutive quarters starting from 4th quarter 2016 and ending with 3rd quarter 2017. The results show that on average, over the four quarters, a 1% increase in foreign banking sector's claims significantly increases U.S. global banks cross border risk exposure by 0.34%, while reducing derivative risk exposure by 0.22%, but have no significant impact on foreign office risk exposure. Similar results are observed with public sector claims which significantly increase banks' exposure to cross border risk by 0.21%, while reducing derivative risk exposure by 0.19%. Conversely however, non-bank financial sector claims are found to have no significant affect on cross-border risk exposure, but significantly reduce foreign office risk exposure by 0.09%, while increasing derivative risk exposure by 0.06%. These results indicate the presence of sectoral heterogeneities in U.S. banks' exposure to foreign counterparties' risk, and also that overall, over the course of 2017 the level of U.S. global banks' cross-border risk exposure increased, while their level of derivative risk exposure decreased, and the level of foreign office risk exposure remained relatively unchanged.

In 2016 northern Nigeria experienced a devastating infestation by the tomato leaf miner, leading to soaring in prices of tomato across the country. Unfortunately, information on the bionomics and resistance status of this pest is lacking in northern Nigeria, hampering appropriate control measures. Here, we identified to species level, and using conventional and synergist bioassays characterised pesticides resistance profile of a field population of a tomato leaf miner from northern Nigeria. Highest resistance was obtained with λ-cyhalothrin (Type II pyrethroid) with a low mortality (18.52% at 56hr) and LD₅₀ of 7461.474ppm. Resistance was also established toward propoxur and chlorpyrifos-methyl with average mortalities each of 56% and LD_50s of 1023.51ppm and 106.351ppm, respectively. Highest susceptibility was seen with abamectin with mortality of 86% and LD₅₀ of 0.034ppm. Pre-exposure to piperonyl butoxide significantly recovered λ–cyhalothrin susceptibility (mortality = 90% and LD₅₀ = 0.92ppm) implicating the P450 monoxygenases in the resistance. No significant changes in mortalities were obtained on pre-exposure to diethyl maleate and triphenyl-phosphate- inhibitors of glutathione S-transferases and carboxylesterases, respectively. The finding of resistance to these agricultural pesticides will sensitize stakeholders across Nigeria to take action to manage the resistance at an early stage before it gets out of hand.

Water scarcity is a significant challenge facing Jordan today. It is a challenge in all areas that use water, and it has become certain that water is the critical factor in the population/resources equation. The water resources in Jordan have become limited with the noticeable increase in the population, mostly resulting from forced migrations in neighboring countries because of the wars and until our time. The rising natural population growth rate, along with the massive influx of refugees, has turned into a state of disproportion between the daily consumption of the population and the amount of water available. That Jordan shares most of its surface water resources with neighboring countries has exacerbated the situation. The current use of water already exceeds its renewable supply. Excessive withdrawal from aquifers, which leads to a lowering of the water table and deterioration in water quality, covered the deficit. This paper focuses on assessing the water situation in Jordan, mainly evaluating this problem and the solution being considered, the true basis for a sustainable water solution requires awareness by the population, and several governmental and non-governmental organizations are actively involved in educating residents about water shortages. The most important and 'actionable' elements of comprehensive water solutions are discussed in this paper, and these elements exist, develop extra water supplies, water harvesting, water desalination, proper wastewater reuse in the agricultural sector, and reduce the demand for drinking water. This research provides specific recommendations to address the shortage of water resources in the Kingdom and highlights the importance of water conservation and optimal use.

In order to search possible residual minor phases in Y-Ba-Cu-O family, powdered mixtures of Y₂O₃ + BaCO₃ + CuO and, independently, superconducting compound YBa₂Cu₃O_7-x have been treated in evacuated cells and elevated temperatures.YBa₂Cu₃O_7-x was reduced to YBa₂Cu₃O₅ by use of the special home designed Taconis-Knudsen vacuum device. A subsequent doping by oxygen converts produced insulator YBa₂Cu₃O₅ to semiconductor or metal YBa₂Cu₃O_5+x (0<x<0.3). In addition to YBa₂Cu₃O₅, 0.05 volume percent of the minor delafossite phase Y₂Cu₂O₄ was being spotted in the powder mixture 1/2 Y₂O₃ + 2BaCO₃+6Cu₂O, heated up to 818 °C in an inert gas atmosphere. An attempt to prepare the insulating bulk delafossite samples was successful, and subsequent doping by oxygen produces novel metallic phases.

A text obtained by a Large Language Model (LLM) such as GPT4 usually has issues in terms of incorrectness and hallucinations. We build a fact-checking system 'Truth-O-Meter' which identifies wrong facts, comparing the generation results with the web and other sources of information, and suggests corrections. Text mining and web mining techniques are leveraged to identify correct corresponding sentences; also, the syntactic and semantic generalization procedure adopted to the content improvement task. To handle inconsistent sources while fact-checking, we rely on an argumentation analysis in the form of defeasible logic programming. We compare our fact checking engine with competitive approach based on reinforcement learning on top of LLM or token-based hallucination detection. It is observed that LLM content can be substantially improved for factual correctness and meaningfulness.

In order to investigate the coordination chemistry of O-alkyl N-aryl thiocarbamate ligands, BiI3 has been reacted with two equivalents of MeOC(=S)N(H)Ph in MeCN solution to afford the dinuclear title compound complexes [{I2Bi(μ2-I)2BiI2}{1-MeOC(=S)N(H)Ph}4] 1. Compound 1 has been characterized by IR, UV and NMR spectroscopy, the dinuclear framework has be ascertained by a single-crystal X-ray diffraction study performed at 100 K.

Biodiversity conservation questions human practices towards biodiversity and, therefore, largely conflicts with ordinary societal aspirations. Decisions on the location of protected areas, one of the most convincing conservation tools, reflect such a competitive endeavor. Operations Research (OR) brings a set of analytical models and tools capable of resolving the conflicting interests between ecology and economy. Recent technological advances have boosted the size and variety of data available to planners, thus challenging conventional approaches bounded on optimized solutions. New models and methods are requested to use such a massive amount of data in integrative schemes addressing a large variety of concerns. Here, we provide an overview on the past, present and future challenges that characterize spatial conservation models supported by OR. By enlarging the spatial, temporal, taxonomic and societal horizons of biodiversity conservation planners navigate around multiple bio-socioeconomic equilibria and are able to decide on cost-effective strategies to improve biodiversity persistence.

Urban growth in various cities across the world, especially in developing countries, leads to land use change. Thus, predicting future urban growth in the most rapidly growing region of Nigeria becomes a significant endeavor. This study analyzes land use and land cover (LULC) change and predicts the future urban growth of the Lagos metropolitan region, using Cellular Automata (CA) model. To achieve this, the GlobeLand30 datasets from years 2000 and 2010 were used to obtain LULC maps, which were utilized for modeling and prediction. Change analysis and prediction for LULC scenario for 2030 were performed using LCM and CA_Markov chain modeling. The results show a substantial growth of artificial surfaces, which will cause further reductions in cultivated land, grassland, shrubland, wetland, and waterbodies. There was no appreciable impact of change for bare land, as its initial extent of cover later disappeared completely. Additionally, artificial surfaces/urban growth in Lagos expanded to the neighboring towns and localities in Ogun State during the study period, and it is expected that such growth will be higher in 2030. Lastly, the study findings will be beneficial to urban planners and land use managers in making key decisions regarding urban growth and improved land use management in Nigeria.

Microgrids offer flexibility in power generation in a way of using multiple renewable energy sources. In the past few years, microgrids become a very active research area in terms of design and control strategies. Most of the microgrids use DC/DC converters to connect renewable energy sources to the load. In this paper, the simulation model of a DC microgrid with three different energy sources (Lithium-ion battery (LIB), photovoltaic (PV) array, and fuel cell) and external variant power load is built with MATLAB/Simulink and the simulative results show that the stability of DC microgrid can be guaranteed by the proposed maximum power point controller MPPT. The three energy sources are connected to the load through DC/DC converters, one for each. This type of topology ensures protection for each energy source as well as optimum stability at the load.

In March 2020, the World Health Organization declared coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2, to be a pandemic. Since the declaration, Nigeria economy has been greatly impacted thus resulting in a recession. This paper considers a couple of misconceptions among Nigerian people in the COVID-19 pandemic era thereby causing the spread of the novel virus and hence making the situation difficult for the government to handle. In particular, we discuss the first and second waves of the pandemic as it affects the Nigerian people. The impact of the pandemic on animals and the role of mathematical epidemiologists in combatting the spread is discussed herein. We give some recommendations that could be adopted by the government and the good people of Nigeria to reduce the further spread of the virus.

Guava (Psidium guajava L.) is a common fruit tree that grows in several tropical and subtropical parts of the world. The aim of this study was to employ the use of liquid-liquid fractionation to investigative the comparative antibacterial potential of crude extracts of Guava leaves and bark against selected food isolates; Escherichia coli, Pseudomonas aeruginosa, Streptococcus pneumonia, Bacillus cereus and Staphylococcus aureus. The phytochemical analysis of the extract showed presence of tannin, phenol, flavonoid and terpenoid in all extract, while steroid and saponin were absent in some. The agar diffusion method was employed for the assessment of the sensitivity of the extracts. The ethyl acetate and aqueous fractions from the stem bark acetone extract generally showed better antimicrobial activity compared with other extracts from leaves. The extract was active both against gram positive bacteria (Bacillus cereus and Streptococcus pneumonia) and gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, , Bacillus cereus and Staphylococcus aureus) at varying zone of inhibition. The results of the study showed the potential of identifying novel antibacterial agent from P. guajava bark and leaves while optimising the potential application for treatment in traditional medicine.

Salmonellosis is a bacterial zoonosis with array of health conditions. Non-typhoidal salmonellosis (NTS) have a discrete adaptation to certain animals; in poultry, pullorum and fowl typhoid are its primary disease manifestations. The diseases are prevalent in the Nigerian poultry and have been well studied in Nigeria, but less so in the north central Nigeria (NCN). Using field sampling, laboratory methods and semi structured questionnaire in 1000 poultry farms from NCN, we explore the incidence and risk factors for the persistence of NTS infection in poultry. Approximately 41.6% of the farms have experienced NTS but only 6.3% have current infection with NTS. Farm experience of NTS moderately predicted awareness of salmonellosis. Increasing stock in smallholder farms, self-mixing of concentrate on the farm, usage of stream water, pen odour, non-adherence and partial adherence of farms to recommended poultry vaccination against pullorum and fowl typhoid, and lack of and non-adherence to biosecurity were identified risk factors that increased the odds of NTS infection in poultry. Antibiotic use practice may have reduced the isolation rate of NTS, yet NTS continues to challenge poultry farms in Nigeria. Identified risk practices must be mitigated intentionally and biosecurity and hygiene must improve to reduce the burden of NTS.

Soil amendments with composted organic materials are recommended to increase soil organic matter (SOM), promote soil fertility, and the Circular Economy. Growing areas of hedged olive groves in southern Iberia peninsula generate huge amounts of olive leaves whose potential as soil organic amendment is not fully studied. An experimental field trial in a hedged olive grove (cv. “Cobrançosa”) was set up near Portalegre, Portugal, to test a compost of olive leaves plus sheep manure (2:1) applied in the row, at soil surface. Three nominal rates (0 or control, 2.5 and 5.0 kg m-2) were used, in a complete randomized block setup (3 treatments, 3 replicas, 9 plots) and soil chemical properties of layers 0-5, 5-15, and 15-30 cm deep were annually monitored. Results (mainly in layer 0-5 cm) showed increases in total N, carbon of the particulate organic matter (POM-C), permanganate oxidizable carbon (POX-C), extractable phosphorus, and zinc, after one year, and increases in soil organic carbon (SOC), C-stock, pHKCl, extractable phosphorus, and zinc, after two years. POX-C was the most sensitive SOM-related indicator, showing increases up to 30 cm deep after one year. This compost improved soil fertility, but should be monitored over longer periods of time, namely for SOC and extractable zinc content.

The complexity of software is increasing day by day due to the increase in the size of the projects being developed. For better planning and management of large software projects, estimation of software quality is important. During the development processes, complexity metrics are used for the indication of the attributes/characteristics of the quality software. There are many studies about the effect of the complexity of the software on the cost and quality. In this study, we discussed the effects of software complexity on the quality attributes of the software for open source and closed source software. Though, the quality metrics for open and closed source software are not distinct from each other. In this paper, we comparatively analyzed the impact of complexity metrics on open source and private software. We also presented various models for the management of the project complexity such as William’s Model, Stacey’s Agreement and Certainty matrix, Kahane’s Approach and UCP Model. Quality metrics here refer to the standards for the measurement of the quality of software which contains certain attributes or characteristics of the software that are related to the quality of the software. Certain quality attributes addressed in this study are Usability, Reliability, Security, Portability, Maintainability, Efficiency, Cost, Standards and Availability, etc. Both Open source and Closed source software are evaluated on the basis of these quality attributes. This study also recommended future approaches to manage the quality of project Open source and Closed source software and specify which one of them is mostly used in the industry.

ZrO2-YO1.5-TaO2.5(ZYTO) composite ceramic is considered to be the candidate of next generation of thermal barrier coatings as its excellent thermal stability and low thermal conductivity in high temperature, however, the mechanical properties and fracture tougheness of ZYTO system may be the shortcomings compared with the 8YSZ. In this study, ZYTO composite ceramics were successfully prepared by chemical coprecipitation reaction, the microsture of resulting composites were studied as a function of doping of M-YTaO4. Mechanical properties, including the density, porosity, hardness and Young's modulus, are determinate; the toughening mechanism were verified by the crack growth behavior of Vickers indentation test Results suggested that M-YTaO4 refines the fluorite phase grain and strengthens the grain interface in the composite ceramic. The thermal mismatch between the second phase and matrix produces residual stress in the bulk and affects the crack propagation behavior. With the increase of M-YTaO4 doping, the grain coarsening and ferroelastic domains are observed in the experiments. The ferroelastic domains with orthogonal polarization directions near crack tip evidences the ferroelastic toughening mechanism. The competition among these crack behaviors, such as cracks deflection, bridging and bifurcation, dominates the actual fracture toughness of the composite. The best toughening formula is determinate in the two-phase region and the highest fracture toughness is about to 3.1MPa·m1/2. Above all, mechanical properties of ZYTO composite ceramics look potential for thermal barrier coatings materials.

Abstract: Objective: Internet gaming disorder (IGD) is an emerging psychiatric disorder that has received attention over the past decade. Few studies have attempted to describe this disorder in the Saudi population. This study aimed to examine the prevalence of IGD and associated factors. A cross-sectional study was conducted using translated Arabic and a validated questionnaire targeting both genders in Saudi Arabia. Methodology: A cross-sectional study using a validated questionnaire (IGD-20) and targeting Arabic-speaking children, youth, and transitional age including both genders. A snowball approach was used to sample our population using an electronic survey. Logistic regression was used to examine factors associated with IGD diagnosis. The study was guided by the STROBE statement. Results: Among 419 individuals who participated in the study, 171 were classified as non-IGD, 167 were at risk for IGD (RIGD), and 72 were IGD. There is no significant association between IGD diagnosis and gender, nationality, residence, and family income. Time playing per week was significantly associated with IGD diagnosis (X2=49.256, p<0.01). There is a significant association between IGD-20 groups and categorical age groups (X2=10.096, p<0.01). Among our sample, the percentages of males (54.2%) and females (45.8%) who met the criteria for IGD were comparable. Conclusion: IGD and RIGD prevalence was significantly high in both age groups. Both males and females were affected similarly.

Research into lightweight structural concrete using volcanic tuff is of great importance to the construction industry. These materials have excellent thermal insulation properties, which helps improve the energy efficiency of buildings. A three-factor experimental design was used to build the statistical model. The test methods used were methods for determining the crushability of volcanic tuff, determining the average density, compressive strength and thermal conductivity of lightweight structural concrete. The influence of basalt fiber on the properties of lightweight structural concrete has been determined. The optimal compositions of lightweight structural concrete using tuff have been selected. The compressive strength of lightweight structural concrete reached 32.0 MPa. The average density range is 1754.6-2114.0 kg/m³. Good thermal conductivity values ​​were obtained in the range of 0.653-0.818 W/m·K. The article obtained the optimal compositions of lightweight structural concrete using volcanic tuff as a filler.

Cybercrime Threat Intelligence (CTI) allows us to change our actions from reactive to proactive in the fight against threat actors, and to make more informed, data-driven security decisions. Thus this study proposes the practical implementation of CTI in the Arab world. This study focuses on strengthening CTI by integrating Indicators of Compromise (IoCs) and collecting realistic security alerts from honeypot systems and open source intelligence. The collected data is stored in the Malware Information Sharing Platform (MISP), an open source platform that allows users to create and share IoCs with other organizations while staying informed about new threats. It features an intuitive interface for data analysis and threat identification, facilitating sharing, storage, and correlation of IoCs. Therefore, we leveraged MISP to generate IoCs based on the collected data and analyzed the results to identify potential cyber threats. The implemented platform aims to provide organizations with actionable information to prevent, detect and respond to cybercrime. This study presents a practical approach to strengthening CTI in the Arab world and provides an opportunity to strengthen the region’s security posture.

Abstract. Results of research into four-membered phosphorus(V)-heterocycles, 2-halogen-1,2λ⁵-oxaphosphetanes are presented. The preparation of 2-halo-1,2λ⁵-oxaphosphetanes by reaction of P-haloylides with carbonyl compounds is described. The mechanism of asynchronous [2+2]-сycloaddition of ylides to aldehydes was proposed on the base of low-temperature NMR investigations. 2-Halogen-1,2λ⁵-oxaphosphetanes were isolated as individual compounds and their structures were confirmed by ¹Н, ¹³C, ¹⁹F and ³¹Р NMR spectra. These compounds are convenient reagents for preparing of various organic and organophosphorus compounds hardly available by other methods. Chemical and physical properties of the 2-halo-1,2λ⁵-oxaphosphetanes are reviewed. The 2-chloro-1,2λ⁵-oxaphosphetanes depending on substituents at the α-carbon atom rearrange with formation of 2-chloroalkylphosphonates or convert into trans-phosphorylated alkenes. Prospective synthetic applications of 2-halo-1,2λ⁵-oxaphosphetanes are analyzed. The 2-halo-1,2λ⁵-oxaphosphetanes may be easily converted to various alkenylphosphonates: allyl- or vinylphosphonates, phosphorus ketenes, thioketenes, ketenimines.

Vasculitis diseases include Kawasaki Disease (KD), Kawasaki Disease Shock Syndrome (KDSS), Multisystem Inflammatory Syndromes (MIS), Henoch-Schönlein purpura (HS) or IgA Vasculitis, and additional vasculitis diseases. These diseases are often preceded by infections or immunizations. Disease incidence rates are higher in children than adults. These diseases have been extensively studied, but understanding of the disease etiology remains to be established. Many studies have failed to demonstrate an association between these vasculitis diseases and vaccination. Here, the Vaccine Adverse Event Reporting System (VAERS) is used to demonstrate that, in certain rare cases, the number of cases of KD, MIS, and HS is higher than background following vaccination. These rare cases are predicted to occur in individuals with genetic risk factors who produce antibody titer levels above primary immune response level. Herein, the model of humoral immune response antibodies bound to antigens (pathogen or vaccine) creating immune complexes is proposed. These immune complexes are proposed to bind Fc receptors on immune cells and platelets resulting in cell activation and release of inflammatory molecules including histamine and serotonin. Immune complexes and inflammatory molecules including serotonin and histamine likely trigger vasculitis. Elevated serotonin and likely histamine drive initial vasoconstrictions disrupting blood flow. Increased blood flow pressure from cardiac capillary vasoconstrictions is predicted to trigger coronary artery aneurysms in some patients. For KDSS and MIS patients, these cardiac capillary vasoconstrictions are predicted to result in ischemia followed by ventricular dysfunction. Ongoing ischemia can result in long-term cardiac damage. Cases associated with pathogens are likely to have persistent infections triggering disease onset.

The photodegradation of azithromycin present was carried out in water using H2O2 under UV irradiation. The reaction variables considered in this study were the amount of H2O2 solution and the initial concentration of azithromycin to evaluate the performance of the photodegradation process. The azithromycin degradation was not observed in the dark during stirring for 20 minutes. The study showed efficient photodegradation of azithromycin using H2O2 as an oxidant in the presence of UV irradiation. The azithromycin degradation was affected significantly by the pH of the irradiated solution. The degradation was low at an acidic pH and showed an increasing trend as the pH changed to basic. The azithromycin degradation was increased with a higher amount (higher concentration) of H2O2. The degradation of azithromycin decreased with a higher concentration of azithromycin in the reacting solution. The highest degradation of AZT was achieved in 1 hour using a 1.0 ppm AZT solution containing 3 ml of H2O2. The experimental data obtained was well-fitted to zero-order reaction kinetics. The results of this study were found to be superior when compared with those reported in the literature, with photocatalysis using nanomaterials and photolysis using irradiation and H2O2. The UV/H2O2 system was found to be quite efficient for the photodegradation of azithromycin, and this system can be applied to degrade other organic pollutants present in industrial wastewater. To this point, such a study has not been reported specifically for AZT photodegradation.

This article explores the possible ramifications of incorporating ideas from AEC Industry 6.0 into the design and construction of intelligent, environmentally friendly, and long-lasting structures. This statement highlights the need to shift away from the current methods seen in the AEC Industry 5.0 to effectively respond to the increasing requirement for creative and environmentally sustainable infrastructures. The preceding methodology, AEC Industry 6.0, has substantially improved the efficacy and sustainability of construction by using new technology, digitalization, and environmentally conscious methods. Extensive discussions have occurred on the various benefits of AEC Industry 5.0. These merits include heightened stakeholder involvement, increased efficiency via automation and robots, decision-making processes centered around data, and the optimization of resources. Nevertheless, this study also examines the obstacles linked to the complete adoption of AEC Industry 6.0. These challenges require proficient professionals who can effectively utilize contemporary technologies, manage diverse stakeholder technological competencies, establish interoperable systems and standards, and reinforce cybersecurity measures. This study examines the viability of implementing concepts from Industry 6.0 to create intelligent, sustainable, and environmentally friendly structures. The objective is to showcase the potentially revolutionary impact that these principles may have on the construction industry. This study explores the possible applications of AEC Industry 6.0 within the Architecture, Engineering, and Construction (AEC) sector, explicitly highlighting the anticipated industry-wide consequences of the forthcoming paradigm shift. This paper comprehensively examines big data analytics, the Internet of Things (IoT), and collaborative robots as they pertain to the AEC Industry 6.0. This research investigates the interplay between organizational dynamics, human actors, and robotic systems to provide light on the opportunities and obstacles associated with integrating AEC Industry 6.0 concepts into the construction of buildings.

This study used eco-friendly materials known as Periwinkle Shell Powder (PSP) in stabilizing the engineering properties of lateritic soil. Preliminary test was performed on the un-stabilized lateritic soil for the purposes of identification and classification (natural moisture content, liquid limits, plastic limits, and plasticity index). The engineering tests were conducted on the lateritic soil stabilized with additions of (2, 4, 6, 8 and 10 %) PSP and OPC respectively. The result showed that cement gave a progressive increase in the Maximum Dry Density (MDD) of the lateritic soil from 1875 kg/m3 (2 %) to 2294 kg/m3 (10 %) respectively. This represents 22 % increase in the MDD from the un-stabilized state. For PSP, the Maximum MDD was attained at 6 % (1974 kg/m3), representing 5.3 % increase in MDD of the soil from the un-stabilized state. For both stabilizing agent, the Optimum Moisture Content (OMC) increases from 13.65 % to 13.83 % and from 11.72 % to 14.41 % for Cement and Periwinkle Shell Powder respectively. PSP recorded an increase of 5.6 % of CBR value compared with OPC that recorded an increase of 34 % CBR value. The study therefore concluded that Periwinkle Shell Powder (PSP) could be considered as good stabilizer for clayey or lateritic, and its uses as a stabilizer could also provide a big relief to the environmental pollution caused by its indiscriminate dumping.