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Preprint REVIEW | doi:10.20944/preprints202007.0020.v1

High Homogenization Pressures to Improve Food Quality, Functionality and Sustainability

José Mesa, Leidy Indira Hinestroza-Córdoba, Cristina Barrera, Lucía Seguí, Ester Betoret, Noelia Betoret

Subject: Biology And Life Sciences, Food Science And Technology Keywords: High homogenization pressure; food functionality; bioactive components; agri-food waste; sustainability

Online: 3 July 2020 (08:39:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0982.v1

Implementation of a Grupal Intervention Program for the Treatment of Obesity in Children: PinPO.

MARIA JOSE COMINO-MONROY, WENCESLAO FERNANDEZ-GALLARDO, Mercedes Gil-Campos, MANGELES ALARCON-ROLDAN, CRISTINA CASTRO-COLLADO, BARBARA LUQUE, SEBASTIAN VIVAS, KATHERINE FLORES-ROJAS

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: childhood; grupal intervention; habits; obesity; treatment

Online: 12 July 2024 (05:57:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0063.v1

Intangible Cultural Heritage and Sustainable Tourism in Córdoba, Spain

Francisco González Santa Cruz, Tomás López-Guzmán

Subject: Business, Economics And Management, Business And Management Keywords: cultural tourism; world heritage site; sustainability; satisfaction; cordoba; Spain

Online: 13 March 2017 (09:23:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0131.v1

Salmonella Inactivation Model by UV-C Light Treatment in Chicken Breast

Rosa María García-Gimeno*, Guiomar Denisse Posada-Izquierdo, Eva Palomo-Manzano, Poliana Mendes de Souza

Subject: Public Health And Healthcare, Other Keywords: non-thermal treatment; UV-C; low transmittance food; mathematical modelling; foodborne pathogens

Online: 2 August 2024 (06:04:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1606.v1

Prediction of Seizure Stages Based on Electroencephalography Signals and Machine Learning

Kusumika Krori Dutta, Premila Manohar, Indira K

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: FH; RF; KNN; CHB-MIT; TUHEEG; EEG; Epilepsy; Seizure stages

Online: 25 July 2023 (03:25:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1675.v1

Sexual and Metabolic Differences in the Evolution of the Hippocampal Brain Tissue. Relationship with the Glucidic Metabolism-Alzheimer’s Disease Binomial

Jose Manuel Martínez-Martos., Vanesa Cantón-Habas, Manuel Rich-Ruiz, María José Reyes-Medina, María Jesús Ramírez-Expósito, María del Pilar Carrera-González

Subject: Biology And Life Sciences, Aging Keywords: Hippocampus; Alzheimer's disease; glucose transporters; GLUT4; renin angiotensin system; insulin regulated aminopeptidase; sex; brain

Online: 24 September 2024 (03:53:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0794.v1

Physicochemical and Rheological Characteristics of Fermented Sour Cream (“Suero Costeño”) Produced in Colombia

María Ruiz-Petro, María Torres-Ruiz, Monica Simanca-Sotelo, Beatriz Álvarez-Badel, Alba Durango-Villadiego, Margarita Arteaga-Márquez, Claudia De Paula, Yenis Pastrana-Puche, Clara Gutiérrez-Castañeda, Ilba Burbano-Caicedo, Amner Muñoz-Acevedo, Ruben Godoy-Gutiérrez, and Ricardo Andrade-Pizarro

Subject: Biology And Life Sciences, Food Science And Technology Keywords: fermented milk; artisanal product; pseudoplastic fluid; thixotropic

Online: 13 May 2024 (07:55:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0232.v1

Computational Characterization of the mtORF of Pocilloporid Corals: Insights into Differences in Protein Structure and Function among Stylophora Lineages from Contrasting Environments

Eulalia Banguera-Hinestroza, Yvonne Sawall, Jean-François Flot

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: protein function, mtORF, Stylophora, thermal adaptation, disordered amino acids residues, pocilloporid corals, a transmembrane protein, pocilloporid corals.

Online: 23 January 2019 (08:58:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1443.v1

A Cyber-Physical System Based on Digital Twin and 3D SCADA for Real-Time Monitoring of Olive Oil Mills.

Cristina Martinez-Ruedas, Jose-Maria Flores-Arias, Isabel M. Moreno-Garcia, Matias Linan-Reyes, Francisco Jose Bellido-Outeiriño

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: CPS (Cyber Physical System); Digital Twin; Virtual Reality; OPC UA; Smart Factory; Virtualization; 3D SCADA; WinCC OA.

Online: 25 March 2024 (08:48:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0348.v1

Advancing Research Training in Medical Education: Global Perspectives and Paradigms for Future Development

Yasar Ahmed, Sima Khayal

Subject: Medicine And Pharmacology, Other Keywords: research; training; medical; curriculum

Online: 6 February 2024 (09:37:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.0002.v1

The Microalgae Chlamydomonas for Bioremediation and Bioproduct Production

Carmen M Bellido-Pedraza, Maria J Torres, Angel Llamas

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Microalga; Chlamydomonas; bioremediation; wastewater; high-value-added products

Online: 3 June 2024 (08:35:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0587.v1

Novel Dry Powder of Hyaluronic Acid-Vancomycin Complex for Inhalation Useful on Pulmonary Infections Associated to Cystic Fibrosis

María Sol Magi, Yanina De Lafuente, Eride Quarta, María Celeste Palena, Perla Ardiles, Paulina Laura Páez, Fabio Sonvico, Francesca Buttini, Alvaro Jimenez-Kairuz

Subject: Chemistry And Materials Science, Other Keywords: Vancomycin inhalable; cystic fibrosis; polyelectrolyte-drug complex; hyaluronic acid; pulmonary infection

Online: 12 February 2024 (04:53:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1664.v2

Dissolving the Self, Embracing the Earth: A Philosophical Exploration of Psychedelics, Self-Transcendence, and Environmental Connection

Muzamil Hussain

Subject: Social Sciences, Psychology Keywords: Psychedelics; Ego Dissolution; Self-Transcendence; Interconnectedness; Deep Ecology; Environmental Philosophy; Consciousness Studies

Online: 26 April 2024 (12:50:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1616.v1

Antibacterial and Antibiofilm Potential of Ethanolic Extracts of Duguetia vallicola (Annonaceae) against in-Hospital Isolates of Pseudomonas aeruginosa

Orfa Inés Contreras-Martínez, Daniela Sierra-Quiroz, Alberto Angulo-Ortíz

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Ethanolic extracts; Duguetia vallicola; antibacterial activity; antibiofilm; Pseudomonas aeruginosa.

Online: 26 March 2024 (16:58:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202105.0555.v1

Technologies for the Development of New Value-Added Foods From Dates and Their Processing by-Products

Alex López-Córdoba

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Value addition; Functional Foods; Phoenix dactylifera; Innovation; Differentiation

Online: 24 May 2021 (10:25:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1082.v1

Intercropping as a Strategy for Weed Management in Faba Bean (Vicia faba L.)

Ángel M. Villegas-Fernández, Ahmed A. Amarna, Juan Moral, Diego Rubiales

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: allelopathy; faba bean; intercropping; weeds

Online: 17 April 2024 (07:21:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2069.v1

FaNPR3 Members of the NPR1-Like Gene Family Negatively Modulate Strawberry Fruit Resistance against Colletotrichum acutatum

Victoria Súnico, José Javier Higuera, Francisco Amil-Ruiz, Isabel Arjona-Girona, Carlos J. López-Herrera, Juan Muñoz-Blanco, Ana María Maldonado-Alconada, José L. Caballero

Subject: Biology And Life Sciences, Plant Sciences Keywords: Fragaria ananassa; strawberry defense; strawberry resistance; Colletotrichum acutatum; FaNPR3; NPR-like genes; AtNPR3; AtNPR4; FaWRKY19; FaWRKY24

Online: 25 July 2024 (14:06:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0909.v1

Design of a Long-Throated Flume in a Drainage Channel of a Rice Cultivated Plot

María Fátima Moreno-Pérez, Francisco Javier Pérez-Ardoy, José Roldán-Cañas

Subject: Engineering, Civil Engineering Keywords: long-throated flume; drainage channel; rice irrigation; Excel spreadsheet

Online: 14 May 2024 (06:50:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0298.v1

Implementation of Low Carbon Supply Chain Management Practices (LCSCMP) in Indian Manufacturing Industries Using ISM-DEMATEL

Vivek Gupta, Arvind Jayant, Kulwant Singh

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: LCSCM; MICMAC; ISM; DEMATEL; Multi criteria decision making

Online: 7 May 2024 (02:40:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0780.v1

Combined metabolomic and NIRS analyses reveal biochemical and metabolite changes in goat milk kefir under different fermentation times

Rubén Sánchez-Rodríguez, Carlos Terriente, Juan García-Olmo, Sonia Osorio, Manuel J. Rodríguez-Ortega

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: fermented milk; metabolome; metabolites; near infrared spectroscopy; sample classification

Online: 12 June 2024 (11:58:30 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202308.0908.v1

Implementation of the Electrosurgical Checklist in a Podiatry Unit in Relation to a Case of Inadvertent Burns during Hallux Valgus Surgery

Antonio Córdoba-Fernández, María Dolores Jiménez-Cristino, Victoria Eugenia Córdoba-Jiménez, Francisco Javier Mármol-García

Subject: Biology And Life Sciences, Life Sciences Keywords: electrosurgical injury; monopolar diathermy; burns; electrosurgical safety

Online: 11 August 2023 (08:25:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1079.v1

Comparative Transcriptome Analysis of Shiga Toxin-Producing Escherichia coli O157:H7 on Bovine Rectoanal Junction Cells and Human Colonic Epithelial Cells During Initial Adherence

Lekshmi K. Edison, Indira T. Kudva, Subhashinie Kariyawasam

Subject: Biology And Life Sciences, Food Science And Technology Keywords: adherence; biofilm formation; colonic epithelium; rectoanal junction; Shiga toxin-producing Escherichia coli; transcriptomics; virulence genes

Online: 15 September 2023 (12:03:12 CEST)

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Shiga toxin-producing Escherichia coli (STEC) are notorious foodborne pathogens capable of causing severe diarrhea and other life-threatening complications in humans. Cattle remain a major reservoir and asymptomatic carriers of STEC. In reservoir animals, the rectoanal junction (RAJ) serves as the primary colonization site of STEC playing a critical role in its transmission to humans through contaminated food sources. However, the molecular mechanisms behind the adaptation of STEC in the RAJ of the asymptomatic reservoir host and its subsequent infection of human colonic epithelial cells in an event of a foodborne transmission to cause diarrhea remain largely unexplored. This study aimed to unravel the intricate dynamics of STEC O157:H7 serotype in these two distinct host environments: bovine RAJ cells and human colonic epithelial cells, during initial colonization. In this context, comparative transcriptomics analysis was employed to investigate the differential gene expression profiles of STEC O157:H7 during its interaction with these cell types. The bacterial cells were cultured under controlled conditions to simulate the microenvironments of both bovine RAJ and human colonic epithelial cells. Using high-throughput RNA sequencing, we identified key bacterial genes and regulatory pathways that were significantly modulated in response to each specific host environment. Our findings reveal distinct expression patterns of bacterial genes involved in virulence, including adherence, metal iron homeostasis and stress response in STEC O157:H7 grown in bovine RAJ cells as op-posed to human colonic epithelial cells six hours post-infection. Additionally, the comparative analysis highlights the potential role of certain genes in host adaptation and tissue-specific pathogenicity. Furthermore, this study sheds light on the potential factors contributing to the survival and persistence of STEC O157:H7 in the bovine reservoir, and its ability to colonize in-testinal epithelium and cause disease in humans.

Preprint ARTICLE | doi:10.20944/preprints201809.0484.v1

Characterization of Sex with Animals in Córdoba, Colombia. An Exploratory Study

Óscar Adolfo Medina-Pérez, Liliana Marcela García-Vega, Jean Paulina Villard Plaza, Juan Carlos Ortiz Valencia

Subject: Social Sciences, Psychology Keywords: Bestiality; Colombia; sexual behavior; sexuality; Zoophilia

Online: 25 September 2018 (11:49:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0419.v1

Modeling Analytical Streams for Social Business Intelligence

Indira Lanza-Cruz, Rafael Berlanga, María José Aramburu

Subject: Computer Science And Mathematics, Information Systems Keywords: social business intelligence; data streaming models; linked data

Online: 26 June 2018 (12:48:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0708.v1

Molecular and Associative Evaluation of ERG11, ERG3, CDR1, and SNQ2 Genes Linked to Fluconazole Resistance in Candida glabrata in a Colombian Population

Leidy Yurany Cárdenas Parra, Ana Elisa Rojas Rodríguez, Jorge Enrique Pérez Cárdenas, Juan Manuel Pérez-Agudelo

Subject: Public Health And Healthcare, Other Keywords: Candida glabrata; fungal drug resistance; reverse transcriptase polymerase chain reaction; fluconazole; molecular docking simulation; multivariate analysis

Online: 11 October 2023 (12:24:15 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202407.2449.v1

Dengue Virus Neutralizing Antibodies in Bats from the Yungas Rainforest in Northwestern Argentina

Kevin Ale Rucci, Luis Ignacio Ferro, Maria Cecilia Castilla, Alejandro Alberto Schaaf, Javier Aguilar, Adrian Alejandro Farias, José H. Urquizo, Agustina Murgia, Lorena Ivana Spinsanti, Adrian Diaz

Subject: Biology And Life Sciences, Virology Keywords: arboviruses; flavivirus; Chiroptera; Argentina; neutralizing antibodies; spillback

Online: 30 July 2024 (13:52:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2168.v1

Reflections of Adult Learners on Binge-Watching and its Detrimental Impact on the Environment in West Bengal, India

Soumita Chakraborty, Nabin Thakur

Subject: Social Sciences, Cognitive Science Keywords: binge-watching; carbon emission; detrimental impacts; environment; screen-time

Online: 26 July 2024 (12:58:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0379.v1

Host-Pathogen Interactions during STEC Adherence and Colonization in the Bovine Gut: A Comprehensive Review

Lekshmi K. Edison, Indira T Kudva, Subhashinie Kariyawasam

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Zoonotic transmission; food safety; public health; virulence factors

Online: 5 September 2024 (00:27:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2224.v1

Dynamic Fitting Strategy for Physiological Models: A Case Study of Cardiorespiratory Model for Simulation of Incremental Aerobic Exercise

Carlos Andrés Sarmiento, Alher Mauricio Hernández, Leidy Yanet Serna, Miguel Ángel Mañanas

Subject: Engineering, Bioengineering Keywords: Cardiorespiratory system; Computer simulation; Mathematical model; Parameter estimation; Predictive models

Online: 31 May 2023 (10:40:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0383.v1

Carotenoids in Bacteria: Biosynthesis, Extraction, Characterization and Applications

Gerson-Dirceu López, Gerardo Álvarez-Rivera, Chiara Carazzone, Elena Ibañez, Chad Leidy, Alejandro Cifuentes

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Bacterial carotenoids; Cell disruption; HPLC separation; MS analysis; Food and textile applications

Online: 18 August 2021 (14:09:35 CEST)

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Working Paper ARTICLE

Complete Labelling of Pneumococcal DNA-Binding Proteins with Seleno-L-methionine

Fabián Lorenzo-Diaz, Inmaculada Moreno-Córdoba, Manuel Espinosa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Streptococcus pneumoniae; protein purification; protein labelling; seleno-methionine; DNA-protein interactions

Online: 20 May 2019 (10:03:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0109.v1

Impact of Temperature and Precipitation on Solanum Tuberosum Cultivation Using Climate Scenarios to 2100

Lamberto Valqui-Valqui, Leandro Valqui, Leidy G. Bobadilla, Carmen N. Vigo, Héctor V. Vásquez, Carlos I. Arbizu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: economic valuation; potato; yield; profitability; climate change

Online: 9 May 2022 (08:18:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0227.v1

Sustainability Challenge of Eastern Europe - Historical Legacy, Belt and Road Initiative, Population Ageing and Migration

Mihajlo Jakovljevic, Arcadio A. Cerda, Yansui Liu, Leidy Y. García, Yuriy Timofeyev, Kristijan Krstic, John Fontanesi

Subject: Business, Economics And Management, Economics Keywords: Eastern Europe; Balkans; Healthcare; Sustainability; History; Financing; Population Ageing; Migration; Belt and Road Initiative; Sustainable Millennium Development Goals

Online: 10 August 2021 (10:08:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1516.v1

Synergistic Antifungal Effect and In Vivo Toxicity of the Monoterpene Isoespintanol Obtained from Oxandra xylopioides Diels

Orfa Ines Contreras-Martínez, Alberto Angulo-Ortíz, Gilmar Santafé Patiño, Jesus Sierra Martínez, Ricardo Berrio Soto, Joice Margareth de Almeida Rodolpho, Krissia Franco de Godoy, Fernanda De Freitas Anibal, Bruna Dias de Lima Fragelli

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Synergism; antifungal; isoespintanol; in vivo toxicity

Online: 21 August 2024 (11:39:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1162.v1

Cytotoxic Potential of the Monoterpene Isoespintanol against Human Tumor Cell Lines

Orfa Inés Contreras-Martínez, Alberto Angulo-Ortíz, Gilmar Santafé Patiño, Fillipe Vieira Rocha, Karine Zanotti, Dario Batista Fortaleza, Tamara Teixeira, Jesús Sierra Martínez

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Antitumor activity; isoespintanol; monoterpene; cell lines

Online: 20 March 2024 (12:32:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1588.v1

Automatic Detection of Inconsistencies and Hierarchical Topic Classification for Open-Domain Chatbots

Mario Rodríguez-Cantelar, Marcos Estecha-Garitagoitia, Luis D’Haro, Fernando Matía, Ricardo Córdoba

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: chatbots; inconsistent responses; zero-shot topic detection; clustering

Online: 22 June 2023 (10:23:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1729.v1

Assessment of Diversity and Genetic Variability of Guava (Psidium guajava) by Means of Microsatellite Markers in Montería, Córdoba-Colombia

Enrique Pardo-Perez, Elizabeth Ramos-Rivero, Luis Causil-Vargas

Subject: Biology And Life Sciences, Life Sciences Keywords: genetic diversity; genetic variability; microsatellites; allele frequencies; population structure

Online: 28 November 2023 (08:08:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.0734.v1

Advances in Corrosion of High-Temperature Materials: Interfacial Migration and Alloy Design Strategies

Aditya Narayan Singh, S. K. Swain, Abhishek Meena, Mobinul Islam, Kyung-Wan Nam

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: Quantum electron transport (QET); degradation; hot-corrosion; catalysis; Gibbs free-energy; selective oxidation.

Online: 10 July 2024 (12:31:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2157.v1

Variability in the Bioactivities of Wild Populations of Baccharis crispa Spreng. (Asteraceae) from Córdoba, Argentina: Screening of Cytotoxic and Antiviral Activity

Giuliana Lingua, Ana Guadalupe Chaves, Juan Javier Aguilar, Florencia Martinez, Lorena Torres, Enrique Lucini, Marta Contigiani, Susana Nuñez Montoya, Brenda S. Konigheim

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: natural products; population variability; bioactivities; Herpes Simplex virus; Chikungunya virus

Online: 1 August 2023 (10:44:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0818.v1

Construction of the Collection and Billing Process through Process Mining and Business Intelligence. A Case Study of the Colombian Pharmaceutical Sector

Jhon Sanchez, Nestor Darío Duque Méndez, Leidy Lorena Nieto Zamora, Lizeth Daza Quintero, Oscar Mauricio Bedoya Herrera

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: process mining; processes; pharmaceutical sector; business intelligence; DSR

Online: 12 August 2024 (14:02:00 CEST)

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In most organizations there is an information system where data is recorded regarding events, activities, times, and variables associated with the execution of all organizational processes; this information is generally not used to its maximum potential, limited only to the registration of processes. With process mining, a field of engineering research, responsible for the design of processes through mining algorithms, it is possible to characterize bottlenecks, reprocessing, and opportunities for improvement in organizational processes. In this article, the construction of the collection and billing process is carried out in a case study of the Colombian Pharmaceutical sector supported by process mining and business intelligence. The objective of this research is oriented to the construction of the real process of a case study of the pharmaceutical sector in Colombia supported by the alpha mining algorithm, within the framework of process mining and business intelligence to facilitate decision-making at an organizational level. The result of this research is the proposal of a methodology to implement process mining in organizations in the pharmaceutical sector in Colombia supported by the Design Science Research (DSR) methodology and the construction of the real process in the billing and collection case study in the pharmaceutical sector supported by process mining, business intelligence is also used to complement the points of improvement of the accounting process in the case study. In conclusion, the artifact built in DSR shows a rigorous methodology from obtaining data, and types of documents that make up the knowledge base to proceeding to the application of the alpha mining algorithm that built the real billing and collection process of the case study, in which points of reprocessing and activities susceptible to improvements in the case study are evident. As a contribution, this article develops an alternative approach that contributes to the knowledge gap related to the actual construction of billing and collection processes in organizations, which generates an impact an alternative paradigm in the construction of organizational processes, by proposing a methodology that Builds a billing and collection process through process mining complemented by business intelligence.

Preprint ARTICLE | doi:10.3390/sci2020031

Antioxidant Properties of Western Georgia Native Khechechuri Pear

Tamara Gabour Sad, Indira Djafaridze, Aleko Kalandia, Maia Vanidze, Katarina Smilkov, Claus Jacob

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Khechechuri pear; Adjara region; phenolic compounds; catechins; flavonoids; antioxidant activity

Online: 9 May 2020 (00:00:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1075.v1

Genomic Approaches for Drug Repurposing

Kirtan Dave, Meenakshi Sharma, Dahavl Patel, Parmdeep Singh Dhanda, Alpa Yadav, Mukul Jain

Subject: Biology And Life Sciences, Life Sciences Keywords: drug repurposing; genomics; Proteomics; NGS

Online: 17 April 2024 (11:38:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1121.v1

Evaluation of the Effect of Particle Size and Biomass-to-Water Ratio on the Hydrothermal Carbonization of Sugarcane Bagasse

Leidy Natalia Moreno-Chocontá, Alejandra Sophia Lozano-Pérez, Carlos Alberto Guerrero-Fajardo

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: hydrothermal carbonization; platform chemicals; hydrochar; sugarcane bagasse

Online: 20 February 2024 (08:55:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1521.v1

Operation of an Electrical-Only-Contact Photonic Integrated Chip for Quantum Random Number Generation Using Laser Gain-Switching

Seán Ó Dúill, Leidy Rodriguez, David Alvarez-Outerelo, Francisco J. Díaz-Otero, Ankit Sharma, Frank Smyth, Liam P. Barry

Subject: Engineering, Electrical And Electronic Engineering Keywords: random number generation; integrated photonics; photonics integrated circuit; laser; noise; modulation; quantum effects

Online: 22 September 2023 (07:39:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0266.v1

Passive Microwave Radiometry (MWR) and Mirna for Breast Cancer Diagnostics

Sergey Vesnin, Dmitrii K. Chebanov, Leonid Fisher, Olga Fisher, Mike Dixon, Arran Turnbull, Alexey Goltsov, Indira Kudaibergenova, Igor Goryanin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast cancer; early diagnostics; passive microwave radiometry (MWR); MicroRNA (miRNA)

Online: 19 October 2022 (04:11:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1893.v1

Pre-service Science Teachers’ Conceptions about Creativity at School: A Study in the Hispanic Context

Leidy Dahiana Rios-Atehortua, Tarcilo Torres-Valois, Joan-Josep Solaz-Portoles, Vicente Sanjosé-López

Subject: Social Sciences, Education Keywords: Creativity; Science Education; Science Teachers; Pre-service Teachers' Beliefs

Online: 27 June 2024 (00:00:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0124.v1

Use of the Morphological Variation of Wild Populations of Guanchiche (Hoplias microlepis) as an Indicator of Fishing and Environmental Policies in the Guayas Hydrographic Basin (Ecuador)

Ana Gonzalez-Martinez, Carlos Ricardo Delgado Villafuerte, Cecilio Barba, Martin Gonzalez, Antón García Martínez

Subject: Biology And Life Sciences, Aquatic Science Keywords: Guayas River Basin; native resources; morphological differentiation; discriminant analysis; conservation; fishing pressure

Online: 2 August 2024 (03:48:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1152.v1

Postoperative Hypothermia in Patients Undergoing Major Abdominal Surgery: A Cohort Study

Ashuin Kammar-García, Leidy Katerin Romero-Chacón, Sara Gabriela Guadarrama-Tovar, Javier Mancilla-Galindo, Manuel Alberto Guerrero-Gutiérrez, Diego Escarramán-Martínez, Fernando Aguilar-Silva

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Hypothermia; abdominal surgery; Risk factors

Online: 16 May 2023 (10:33:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1201.v1

Determining the Provenance of Traded Wildlife in the Philippines

Kate J. Brandis, Phoebe Meagher, Sabine Schoppe, Kyle Zawada, Indira Widmann, Peter Widmann, Roger Dolorosa, Roxane Francis

Subject: Environmental And Earth Sciences, Ecology Keywords: stable isotopes; illegal wildlife trade; provenance; pXRF; elemental signatures

Online: 16 June 2023 (09:45:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0565.v1

Heart-Cutting Bidimensional Liquid Chromatography for the Simultaneous Analysis of Veterinary Drugs Residues and Nucleotides Monophosphate in Sheep’s Milk

Noelia Caballero-Casero, Diego García-Gómez, José Luis Pérez Pavón, Encarnación Rodríguez-Gonzalo

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Two-dimensional liquid chromatography; heart-cutting 2D-LC; veterinary drug residue; nucleotides monophosphate; sheep’s milk

Online: 11 March 2024 (08:59:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1917.v1

Exploring the Phytochemical Composition and the Bioactive Properties of Malbec and Torrontés Wine Pomace from the Calchaquíes Valleys (Argentina) for their Sustainable Exploitation

Pablo Ezequiel Tapia, Ana Margarida Silva, Cristina Delerue-Matos, Manuela Moreira, Francisca Rodrigues, Romina Torres Carro, María Daniela Santi, María Gabriela Ortega, María Amparo Blázquez, Mario Eduardo Arena, María Rosa Alberto

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Vitis vinifera; antioxidant; cancer cell cytotoxicity; tyrosinase; lipoxygenase; xanthine oxidase

Online: 29 May 2024 (07:34:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0337.v1

Sustainable Biotechnology Approaches Using Chlorella vulgaris's Biomass and Lipids as Biofuel Feedstock

Harjeet Singh, Mukul Jain, Kirtan Dave, Shivani R. Pandya, Alpa Yadav, Meenakshi Sharma, Prashant Kaushik

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chlorella vulgaris; microalgae; Algal biorefineries; Biodiesel; bioenergy

Online: 7 May 2024 (08:17:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0557.v1

Comparison between Ultrasonographic-Guided Temporal and Coronoid Approaches for Trigeminal Nerve Block in Dogs: A Cadaveric Study

Álvaro Jesús Gutiérrez Bautista, Manon Mikic, Pablo Otero, Virginia Rega, Francisco Medina-Bautista, José Ignacio Redondo García, Sabine Kästner, Adriano Wang-Leandro

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: mandibular; maxillary; and ophthalmic nerves; regional anaesthesia; canine; orbitotomy; analgesia; computed tomography

Online: 9 May 2024 (09:16:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1564.v1

Inheritance of the Flesh Color and Shape of the Tuberous Root of Sweet Potato (Ipomoea batatas [L.] Lam.)

Alfredo Morales, Iván Javier Pastrana Vargas, Dania Rodríguez Del-Sol, Orelvis Portal Villafaña, Yoel Beovides García, Yuniel Rodríguez García, Alay Jiménez Medina, Yusbiel León Valdivies, Vaniert Ventura Chávez

Subject: Biology And Life Sciences, Plant Sciences Keywords: breeding; crosses; dominance; flesh color; inheritance; segregation

Online: 21 August 2024 (11:05:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2271.v1

In situ Entrapment of Catalase within Macroporous Cryogel Matrix for Ethanol Oxidation: Flow-through Mode versus Batch Reactor

Dina N. Akbayeva, Indira A. Smagulova, Kuralay S. Maksotova, Nurly A. Tasbolatova, Botagoz S. Bakirova, Gulnur S. Tatykhanova, Alexey V. Shakhvorostov, Sarkyt E. Kudaibergenov

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: macroporous cryogel; catalase; entrapment; oxidation of ethanol; hydrogen peroxide; molecular oxygen, air; flow-through reactor; batch type reactor

Online: 31 May 2023 (14:47:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0400.v1

Fish Upstream Passage Through Gauging Stations. Experiences With Iberian Barbel in Flat-V Weirs

Francisco Javier Sanz-Ronda, Francisco Javier Bravo-Córdoba, Ana García-Vega, Jorge Valbuena-Castro, Andrés Manuel Martínez-de-Azagra, Juan Francisco Fuentes-Pérez

Subject: Environmental And Earth Sciences, Environmental Science Keywords: gauging weirs; impact; swimming performance; hydraulic barriers

Online: 22 November 2021 (14:05:33 CET)

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Preprint REVIEW | doi:10.20944/preprints202003.0103.v2

MERS-CoV and SARS-CoV Infections in Animals: A Systematic Review and Meta-Analysis of Prevalence Studies

D. Katterine Bonilla-Aldana, María C. Cardona-Trujillo, Alejandra García-Barco, Yeimer Holguin-Rivera, Isabella Cortes-Bonilla, Hugo A. Bedoya-Arias, Leidy Jhoana Patiño-Cadavid, Juan David Tamayo-Orozco, Alberto Paniz-Mondolfi, Lysien I. Zambrano, Kuldeep Dhama, Ranjit Sah, Ali A. Rabaan, Graciela J. Balbin-Ramon, Alfonso J. Rodriguez-Morales

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Coronavirus; SARS-CoV; MERS-CoV; serology; molecular diagnosis; reservoir; public health

Online: 19 May 2020 (04:13:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2100.v1

Paper-Based Analytical Devices Based on Amino-MOFs (Mil-125, UiO-66 and Mil-101) as Platforms towards Biosensing Applications

Sofía V. Piguillem, Germán E. Gomez, Gonzalo R. Tortella, Amedea B. Seabra, Matías D. Regiart, Germán A. Messina, Martín A. Fernández-Baldo

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Analytical device; Paper biosensor; MOFs platform; Biomolecules; Alkaline phosphatase enzyme

Online: 29 August 2024 (09:24:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0219.v1

Course Prophet: A Machine Learning-Based System for Early Prediction of Student Failure in Numerical Methods Course in the Bachelor’s Degree in Engineering at the University of Córdoba, Colombia

Isaac Caicedo-Castro

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Machine learning; educational data mining; supervised methods; classifiers; course failure risk

Online: 3 August 2023 (02:43:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0105.v1

Comparison of Two EpCAM-Based Methods for CTC Detection and Molecular Characterization in Advanced Colorectal Cancer

Santiago Cabezas-Camarero, Virginia De La Orden, Silvia Veganzones-De-Castro, Beatriz Medievo-Valeros, Manuel Enrique Fuentes-Ferrer, Antonio Sánchez-Ruiz, Mariano Provencio, Enrique Aranda, Javier Sastre, Eduardo Díaz-Rubio

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: circulating tumor cells; CTC, liquid biopsy; KRAS; colorectal cancer; EpCAM; CellSearch; IsoFlux; castPCR; intratumor heterogeneity

Online: 21 November 2016 (09:52:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0267.v1

Passage Performance of Technical Pool-Type Fishways for Potamodromous Cyprinids: Novel Experiences in Semiarid Environments

Francisco J. Sanz-Ronda, Francisco J. Bravo-Córdoba, Ana Sánchez-Pérez, Ana García-Vega, Jorge Valbuena-Castro, Leandro Fernandes-Celestino, Mar Torralva, Francisco J. Oliva-Paterna

Subject: Engineering, Civil Engineering Keywords: mediterranean region; river connectivity; fishway assessment; motivation; ascent ability

Online: 23 October 2019 (09:40:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1862.v1

Physicochemical Characterization and Antioxidant Activity of Jara Honey Produced in Western Georgia

Nona Abashidze, Indira Japaridze, Maia Vanidze, Meri Khakhutaishvili, Maia Kharadze, Inga Qarcivadze, Ruslani Davitadze, Aleko Kalandia

Subject: Biology And Life Sciences, Food Science And Technology Keywords: honey; antioxidant activity; Physicochemical; Melissopalynology; Grayanotoxin

Online: 26 June 2024 (12:45:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0273.v1

Pantothenate and L-carnitine Supplementation Corrects Pathological Alterations in Cellular Models of KAT6A Syndrome

Manuel Munuera-Cabeza, Mónica Álvarez-Córdoba, Juan M. Suárez-Rivero, Suleva Povea-Cabello, Irene Villalón-García, Marta Talaverón-Rey, Alejandra Suárez-Carrillo, Diana Reche-López, Paula Cilleros-Holgado, Rocío Piñero-Pérez, José A. Sánchez-Alcázar

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: intellectual disability; KAT6A syndrome; Lysine acetyltransferase 6 A; pantothenate; L-carnitine; histone acetylation

Online: 15 November 2022 (04:14:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.2069.v1

Antioxidants Prevent Iron Accumulation and Lipid Peroxidation, but do not Correct Autophagy Dysfunction or Mitochondrial Bioenergetics in Cellular Models of BPAN

Alejandra Suárez-Carrillo, Mónica Álvarez-Córdoba, Ana Romero-González, Marta Talaverón-Rey, Suleva Povea-Cabello, Paula Cilleros-Holgado, Rocío Piñero-Pérez, Diana Reche-López, David Gómez-Fernández, José M. Romero-Domínguez, Manuel Munuera-Cabeza, Antonio Díaz, Susana Gonzalez-Granero, José M. García-Verdugo, And José A. Sánchez-Alcázar

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: BPAN; WDR45; antioxidants; autophagy; iron accumulation

Online: 31 May 2023 (03:32:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1380.v1

Integration of Marine Spatial Planning and Terrestrial Spatial Planning and Its Implementation in Spain

F. Javier Córdoba-Donado, Vicente Negro-Valdecantos, Gregorio Gómez-Pina, Juan J. Muñoz-Pérez, Luis J. Moreno-Blasco

Subject: Environmental And Earth Sciences, Other Keywords: Marine Spatial Planning (MSP); Terrestrial Spatial Planning (TSP); Integrated Spatial Planning (ISP); integration; climate change; Land-sea interaction, extreme events; disastrous hazards

Online: 22 April 2024 (10:16:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0828.v1

ZEB1 Hypermethylation Is Associated with Better Prognosis in Patients with Colon Cancer

Irene Fernández De Los Reyes, Marisa Gómez-Dorronsoro, Iñaki Monreal-Santesteban, Agustin F Fernandez, Mario Fraga, Pablo Azcue, Laura Alonso, Beatriz Fernandez-Marlasca, Javier Suárez-Alecha, Alicia Córdoba-Iturriagagoitia, David Guerrero-Setas

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: methylation; prognosis; colon cancer; biomarkers

Online: 12 July 2023 (11:09:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.2215.v1

Advancing Sustainable Practice in Additive Manufacturing: A Comprehensive Review on Material Waste Recyclability

Geena Prasad, Arunav H, Dwight S, Madhav B Ghosh, Ayona Jayadev, Deepa Indira Nair

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: additive manufacturing; sustainable manufacturing; waste recycling; 3D printing; decentralized manufacturing; circular economy

Online: 30 August 2024 (05:10:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0449.v1

Actin Polymerization Defects Induce Mitochondrial Dysfunction in Cellular Models of Nemaline Myopathies

Rocío Piñero-Pérez, Alejandra López-Cabrera, Mónica Ávarez-Córdoba, Paula Cilleros-Holgado, Marta Talaverón-Rey, Alejandra Suárez-Carrillo, Manuel Munuera-Cabeza, David Gómez-Fernández, Diana Reche-López, Ana Romero-González, José Manuel Romero-Domínguez, Rocío M. De Pablos, Jose Antonio Sánchez-Alcázar

Subject: Biology And Life Sciences, Life Sciences Keywords: Nemaline myopathy; actin polymerization; mitochondria; linoleic acid; L-carnitine

Online: 7 November 2023 (11:28:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1526.v1

Patient-Derived Cellular Models for Polytarget Precision Medicine in Pantothenate Kinase-Associated Neurodegeneration

Mónica Ávarez-Córdoba, Marta Rey-Talaverón, Suleva Povea-Cabello, Paula Cilleros-Holgado, David Gómez-Fernández, Rocío Piñero-Pérez, Diana Reche-López, Manuel Munuera-Cabeza, Alejandra Suárez-Carrillo, Ana Romero-González, José Manuel Romero-Domínguez, Alejandra López-Cabrera, José Ángel Armengol, Jose Antonio Sánchez-Alcázar

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: neurodegeneration with brain iron accumulation (NBIA); pantothenate kinaseassociated neurodegeneration (PKAN); pantothenate kinase 2 (PANK2); pantothenate; pantethine; vitamin E; omega 3; -lipoic acid; L-carnitine; thiamine; fibroblasts; induced neurons; precision medicine

Online: 22 September 2023 (09:18:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0463.v1

Development and Validation of a Combined RT-LAMP Assay for the Rapid and Sensitive Detection of Dengue Virus in Clinical Samples from Colombia

Katherine Escorcia-Lindo, Leidy Hurtado-Gómez, Juan Sebastian Rosero, Nataly Solano Llanos, Camilo Barrios Sánchez, Anderson Diaz Pérez, Yirys Díaz-Olmos, Jennifer García, Yesit Bello-Lemus, Leonardo C Pacheco-Londoño, Antonio J. Acosta-Hoyos, Lisandro A Pacheco-Lugo

Subject: Biology And Life Sciences, Life Sciences Keywords: RT-LAMP; Dengue virus (DENV); Sensitivity; Point-of-Care

Online: 5 September 2024 (12:37:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0530.v1

Application of a Soil Quality Index (SQI) to Assess Impacts on Stocking Rate Variations in Mediterranean Forests

Picazo-Córdoba M.I, García-Saucedo F., García-Morote F.A., Wic-Baena C., López-Serrano F.R., Rubio-Caballero E.M., Moreno-Ortego J.L., Andrés-Abellán M.

Subject: Environmental And Earth Sciences, Soil Science Keywords: Stocking rate unit; Livestock unit; Forest-pasture systems; Multiparametric index; Environmental impact assessment

Online: 8 February 2024 (16:08:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0373.v1

The Hidden Story on Heterogeneous B-raf V600E Mutation Quantitative Protein Expression in Metastatic Melanoma – Association with Clinical Outcome and Tumor Phenotypes

Lazaro Hiram Betancourt, A. Marcell Szasz, Magdalena Kuras, Jimmy Rodriguez Murillo, Yutaka Sugihara, Indira Pla, Zsolt Horvath, Krzysztof Pawlowski, Melinda Rezeli, Kenichi Miharada, Jeovanis Gil, Jonatan Eriksson, Roger Appelqvist, Tasso Militois, Bo Baldetorp, Christian Ingvar, Håkan Olsson, Lotta Lundgren, Peter Horvatovich, Charlotte Welinder, Elisabet Wieslander, Ho Jeong Kwon, Johan Malm, Istvan Balazs Nemeth, Göran Jönsson, David Fenyo, Aniel Sanchez, György Marko-Varga

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: malignant melanoma; BRAF V600E mutation; proteomics; mass spectrometry genetics; heterogeneity; prognosis

Online: 31 October 2019 (10:36:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1815.v1

An Integrated Approach Based on Clinical Data Together with Metabolites and Biomarkers for the Assessment of the Postoperative Complications after Cardiac Surgery

Peter Meinarovich, Alisa Pautova, Evgenii Zuev, Ekaterina Sorokina, Ekaterina Chernevskaya, Natalia Beloborodova

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aromatic microbial metabolites; sepsis-associated metabolites; 4-hydroxyphenyllactic acid; prognostic models; SOFA

Online: 23 July 2024 (16:04:39 CEST)

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Background: Early diagnosis of postoperative complications is an urgent task, allowing timely prescribing of appropriate therapy and reducing the cost of patient treatment. Prognostic models based on various data could help in the early diagnosis of postoperative complications after cardiac surgery. Objectives: The purpose of the study was to determine whether an integrated approach based on clinical data along with metabolites and biomarkers had greater predictive value than the models built on less data. Methods: The study included patients (n=62) admitted for planned cardiac surgery (coronary artery bypass grafting with cardiopulmonary bypass), who were retrospectively divided into two groups depending on the presence (n=26) or absence (n=36) of postoperative complications of all types. Clinical and laboratory data on the first day after surgery were analyzed. Additionally, patients' blood samples were collected before and on the first day after surgery to determine biomarkers (interleukin-6, procalcitonin, NT-proBNP, high-sensitivity troponin T) and metabolites (8 aromatic and 2 dicarboxylic acids were detected using gas chromatography-mass spectrometry). Results: Patients before surgery, compared with healthy donors, differed in the concentration of metabolites (p < 0.05), and had concentrations of a number of biomarkers exceeding the corresponding reference values. Multivariate PLS-DA models, predicting the presence or absence of postoperative complications, were built using clinical data (ROC-AUC=0.71), concentrations of metabolites and biomarkers (ROC-AUC=0.60), and the entire data set (ROC-AUC=0.75). For comparison we built univariate models using the EuroScore2 (ROC-AUC=0.59) and SOFA (ROC-AUC=0.76) scales; concentrations of lactate (ROC-AUC=0.71), the dynamic changes of 4-hydroxyphenyllactic acid (ROC-AUC=0.69), and the sum of three sepsis-associated metabolites (ROC-AUC=0.70). The proposed complex model using entire data set was comparable to the SOFA scale, which confirms the expediency of searching for new predictive models based on a variety of factors.

Preprint REVIEW | doi:10.20944/preprints202406.0540.v1

Whey as an Optimal Substrate for the Development of Functional Products Enriched with Bioactive Peptides

Margarita Saubenova, Yelena Oleinikova, Alexander Rapoport, Sviatoslav Maksimovich, Zhanerke Yermekbay, Elana Khamedova

Subject: Biology And Life Sciences, Food Science And Technology Keywords: functional products; peptides, whey; fermentation; lactic acid bacteria; proteolytic activity.

Online: 10 June 2024 (08:49:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1023.v1

A Contribution to the Integration of International, National and Local Cultural Heritage Protection through a Multilevel Approach to Planning: A Case Study of the Djerdap Area

Ana Niković, Božidar Manić, Nataša Čolić Marković, Nikola Krunić

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Djerdap; Danube; spatial plan; protected area; cultural heritage; multilevel approach

Online: 16 April 2024 (10:27:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1356.v1

Impact of Southerly Surge on Rainfall Pattern Over Java, Bali, West Nusa Tenggara and East Nusa Tenggara during Asian Winter Monsoon and Its Relationship to MJO Condition

Trismidianto Trismidianto, Didi Satiadi, Wendi Harjupa, Ibnu Fathrio, Risyanto Risyanto, Elfira Saufina, Robi Muharsyah, Danang Eko Nuryanto, Fadli Nauval, Dita Fatria Andarini, Anis Purwaningsih, Teguh Harjana, Alfan Sukmana Praja, Adi Witono, Ina Juaeni, Bambang Suhandi

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Southerly Surge; MJO; Rainfall; Java Island; East Nusa Tenggara

Online: 19 June 2024 (14:10:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1950.v1

A Lightweight and High-Precision Passion Fruit YOLO Detection Model for Deployment in Embedded Devices

Qiyan Sun, Pengbo Li, Chentao He, QiMing Song, Zhicong Luo

Subject: Engineering, Electrical And Electronic Engineering Keywords: passion fruit detection; lightweight; deep learning; knowledge distillation; embedded devices

Online: 29 May 2024 (14:12:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1484.v1

Assessment of SLAM Scanner Accuracy for Outdoor and Indoor Surveying Tasks

Zahra Gharineiat, Fayez Tarsha Kurdi, Krish Henny, Hamish Gray, Aaron Jamieson, Nicholas Reeves

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: SLAM; LiDAR; accuracy assessment; indoor and outdoor; data acquisition

Online: 23 April 2024 (11:59:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1855.v1

Antimicrobial Susceptibility of Uropathogenic Escherichia coli with Analysis of Impact of Socio-Economic Factors in Low, Medium and High-Income Countries

Meher Rizvi, Maria Khan, Amina AL Jardani, Ujjala Ghoshal, Zaaima AL Jabri, Mohammad Ahanjan, Azza AL Mamari, Nawal AL Shizawi, Hiba Sami, Abdullah Balkhair, Adila Shaukat, Alwarith Nasser Salem Alkharusi, Abdulrahman Almahrouqi, Afreenish Hassan, Ajay Kumar, Amal Malehi, Amina Gul, Ashima Singh, Asma Said Hamed AL Shidhani, Areena Hoda Siddiqui, Aruna Poojary, Azza AL Rashdi, Bradley Langford, Dmytro Stepanskyi, Abbas Dolatabadi, Aisha Al Mufraji AL Mufraji, Elham Said Ahmed AL Risi, Garima Kapoor, Isabella Princess, Hatim Ali Eltahir, Hilal Al Sidairi, Kaitlyn Dougherty, Katia Iskandar, Ken Masters, Ibrahim Khalaf Hamdan AL Busaidi, Laila AL Yazidi, Mahfuza Nasrin, Mahmood Salim AL Subhi, Mallika Sengupta Mallika Sengupta, Manisha Khandait, Nada Khalfan AL Tamtami, Nada Khafan Alsiyabi, Nawal AL Kindi, Nazla Musthafa Luthfee, Neha Shreshtha, Nihal Mohamed Amur AL Riyami, Noora Hilal Ali AL Busaidi, Nupur Goel, Oksana Ishchenko, Omnia Mohamed Elnabawy Ahmed Taher, Pragnya Paramita Jena, Rajni Ekadashi, Razan Zadjali, Reba Kanungo, Sara Abolghasemi, Salima Al-maqbali, Sanjay Jaju, Sayantan Banerjee, Shadma Yaqoob, Shahnaz Sali, Shafqat Husnain Khan, Shalini Malhotra, Stephen Hughes, Sundas Shaukat, Syed Mohammed Atif, Vrushali Vishwas Patwardhan, Victorien Dougnon, Wahid Khan, Walid Wali, Zakariya AL Muharrmi, Zeeshana Basit, Jasashree Choudhury, Rachita Pravalina, Sanjeev Singh, Sarman Singh, Neelam Taneja, Raman Sardana, Pawan Kapoor, Rajeev Soman, Rashid Al Abri

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: community acquired UTI; Escherichia coli; antimicrobial susceptibility; Indian subcontinent; MENA; GDP; temperature

Online: 24 September 2024 (12:32:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2202.v1

CSA-SA-CRTNN: A Dual-Stream Adaptive Convolutional Cyclic Hybrid Network Combining Attention Mechanisms for EEG Emotion Recognition

Ren Qian, Xin Xiong, Jianhua Zhou, Hongde Yu, Kaiwen Sha

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: EEG; emotion recognition; attention mechanism; Dual-Stream model; adaptive; hybrid network

Online: 29 July 2024 (10:43:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0276.v1

Methylation-GC-MS/FID-Based Glycosidic Linkage Analysis of Unfractionated Polysaccharides in Red Seaweeds

Barinder Bajwa, Xiaohui Xing, Stephanie A. Terry, Robert J. Gruninger, D. Wade Abbott

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: methylation analysis; reductive hydrolysis; whole food fiber; whole cell wall; anhydro sugar; agarose; carrageenan; sulfated galactan; mixed linkage xylan; principal component analysis

Online: 3 April 2024 (10:33:21 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202402.1644.v2

The Impact of an Online Sleep Education Program (Sleep 101) on Sleep Hygiene and Sleep Behavior in College Students

Johanna Schmickler, Rebecca Robbins, Pallas Snider Ziporyn, Stuart Quan

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: sleep hygiene; sleep behavior; college students; sleep education program

Online: 6 March 2024 (04:49:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0476.v1

Metabolomics on Apple (Malus domestica) Cuticle—Search for Authenticity Markers

Kamila Bechynska, Jiri Sedlak, Leos Uttl, Vit Kosek, Petra Vackova, Vladimir Kocourek, Jana Hajslova

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Malus domestica; apple cuticle; UHPLC-HRMS/MS; metabolomic fingerprints; classification models; markers; wax esters

Online: 8 April 2024 (03:04:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1783.v1

Quantitative Trait Loci Mapping and Candidate Gene Analysis for Fiber Quality Traits in Upland Cotton

Xiaoyun Jia, Hongxia Zhao, Jijie Zhu, Hantao Wang, Shijie Wang, Miao Li, Guoyin Wang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: upland cotton; fiber quality; QTL mapping; candidate gene; qRT-PCR

Online: 25 June 2024 (15:12:46 CEST)

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Superior fiber quality is one of the most important objectives in cotton breeding. To detect the genetic basis underlying fiber quality, an F2 population containing 413 plants was constructed by crossing Jifeng 914 and Jifeng 173, both of which have superior fiber quality, with Jifeng 173 being better. Five fiber quality traits were investigated in the F2, F2:3, F2:4, and F2:5 populations. Quantitative trait loci (QTL) mapping was conducted based on a high-density genetic map containing 11,488 single nucleotide polymorphisms (SNPs) and spanning 4,202.12 cM in length. Transgressive segregation patterns and complex correlations in the five tested traits were observed. A total of 108 QTLs were found, including 27 for fiber length (FL), 16 for fiber strength (FS), 24 for micronaire (MC), 17 for fiber uniformity (FU), and 24 for fiber elongation rate (FE). Chromosome A7 contained 12 QTL, ranking the first. No QTL was found on chromosome D1 and D11. Each QTL contributed 1.98%–21.45% to the phenotypic variation (PV), including 13 major effect QTLs that contributed more than 10% toward PV. Two QTLs could be repeatedly detected in three populations, including qFL-D3-2 in F2, F2:4, and F2:5 with 9.18%–21.45% of PV, qFS-A11-1 in F2:3, F2:4 and F2:5 with 6.05%–10.41% of PV. Another seven stable QTLs could be detected in two populations, including four major effect QTLs: qFL-A12-3, qFS-D10-2, qMC-D6-2, and qMC-D8-1. Fourteen QTL-overlapping regions were found, which might explain the complex correlations among the five phenotypic traits. Four regions on chromosome A11, D3, D6, and D10 covered by both stable and major effect QTLs are promising for further fine mapping. The genomic regions of the two QTLs detected in three populations and the four major effect QTLs contain 810 genes. Gene functional analysis revealed that the annotated genes are mainly involved in protein binding and metabolic pathways. Fifteen candidate genes in the qFL-D3-2 region are highly expressed in fiber or ovules during fiber initiation, elongation, secondary cell wall thickening, or maturation stages. qRT-PCR revealed that Ghir_D03G005440.1 and Ghir_D03G011310.1 may play a role in promoting fiber initiation, Ghir_D03G006470.1 may be beneficial for promoting fiber elongation. This study provides more information for revealing the molecular genetic basis underlying cotton fiber quality.

Preprint ARTICLE | doi:10.20944/preprints202404.1916.v1

Yolo-Chili: An Efficient Lightweight Network Model for Localization of Pepper Picking in Complex Environments

HaiLin Chen, Ruofan Zhang, Jialiang Peng, Hao Peng, Wenwu Hu, Yi Wang, Ping Jiang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Chili Detection,Automatic Picking,Neural Network,Model Compression

Online: 29 April 2024 (11:14:53 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.0793.v1

GreenTray^®, a TIS Bioreactor for Plant Micropropagation and Abiotic or Biotic Stress Bioassays

Ramon Dolcet-Sanjuan, Maria Casanovas, Sandra Franquesa, Eva Alsina, Francisca Carrasco-Cuello, Estanis Torres, Josep Rufat, Cristina Solsona, Neus Teixido

Subject: Biology And Life Sciences, Plant Sciences Keywords: GreenTray®; ; TIS; bioreactor; micropropagation; Biotic and Abiotic Stress Agents Bioassays; Prunus; Pyrus; Malus; Cannabis

Online: 11 April 2024 (11:12:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0498.v1

Treatment of the Fractures of the Humeral Surgical Neck: MIROS versus Intramedullary Nailing. A Retrospective Study

Michelangelo Palco, Gabriele Giuca, Domenico Fenga, Ilaria Sanzarello, Matteo Nanni, Danilo Leonetti

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Proximal Humerus Fractures; MIROS System; Intramedullary Nailing; Orthopedics; Retrospective Study

Online: 6 September 2024 (09:42:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0234.v1

Asymmetric Convolution Guided Multipath Fusion Real-Time Semantic Segmentation Networks

Jie Liu, Bing Zhao, Ming Tian

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Semantic segmentation; Asymmetric convolution; Feature misalignment; High-level semantic information

Online: 3 July 2024 (00:20:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0656.v1

Artificial Cultivation of Aquatic Plants Promotes Nitrogen Transformation and Key Functional Genes in Agricultural Drainage Ditch Sediments in the Yellow River Irrigation Area, China

Yu Hong, Ziqi He, Ruliang Liu, Wenhua Xiang, Pifeng Lei, Xi Fang

Subject: Environmental And Earth Sciences, Ecology Keywords: denitrification; DNRA; functional gene of nitrogen transformation; rhizosphere sediments; Phragmites australis; Typha orientalis

Online: 12 August 2024 (03:16:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0656.v1

Biocontrol Potential of Trichoderma asperellum CMT10 Against Strawberry Root Rot Disease

Ping Liu, Rui Xian Yang, Zu Hua Wang, Yin Hao Ma, Wei Guang Ren, Dao Wei Wei, Wen Yu Ye

Subject: Biology And Life Sciences, Horticulture Keywords: Strawberry root rot; Trichoderma asperellum; biocontrol mechanism; biocontrol efficacy; growth-promoting effect

Online: 14 February 2024 (03:51:50 CET)

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Strawberry root rot caused by Neopestalotiopsis clavispora is one of the main diseases of strawberry and significantly impacts the yield and quality of strawberry fruit. There are now no effective control techniques available except for fungicide sprays, which may directly impact consumers. Biological control is becoming an alternative method for the control of plant diseases to replace or decrease the application of traditional synthetic chemical fungicides. Trichoderma is widely used as a biological agent for controlling strawberry root rot. In order to provide resources for screening the highly effective biocontrol fungus for controlling strawberry root rot caused by Neopestalotiopsis clavispora, the biocontrol mechanism,the control effects of Trichoderma asperellum CMT10 against strawberry root rot and growth-promoting effects on strawberry seedlings were investigated by plate culture, microscopy observation and root drenching methods.The results showed that CMT10 had obvious competitive, antibiotic and hyperparasitism effects on Neopestalotiopsis clavispora CMGF3. The CMT10 could quickly occupy nutritional space, and the inhibition rates of CMT10 against CMGF3 in confrontation culture on 7 d was 65.49%. The inhibition rates of volatile metabolite and fermentation metabolite produced by CMT10 against CMGF3 were 79.67% and 69.84%, respectively. The mycelium of strain CMT10 can act as hyperparasites by making contacting, winding and penetrating hyphae of CMGF3. Pot experiment showed that the biocontrol efficacy of CMT10 on strawberry root rot caused by Neopestalotiopsis clavispora was 63.00%. CMT10 had obvious promotion effect on strawberry growth, the plant height, root length, total fresh weight, root fresh weight, stem fresh weight and root dry weight, with the promotion rates were 20.09%, 22.39%, 87.11%, 101.58%, 79.82% and 72.33%, respectively. Overall, this study showed the ability of Trichoderma asperellum CMT10 to control strawberry root rot and their potential to develop as novel biocontrol agents to replace chemical fungicides for eco-friendly, sustainable agriculture.

Preprint ARTICLE | doi:10.20944/preprints202407.0539.v1

Global Exponential Stability of Impulsive Delayed Neural Networks with Parameter Uncertainties and Reaction-Diffusion Terms

Fei Luo, Weiyi Hu, Enli Wu, Xiufang Yuan

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Reaction diffusion terms; Uncertainty parameters; Impulse; Time-varying delays; Global exponential stability

Online: 5 July 2024 (13:21:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1024.v1

Screen and Character a New Iflavirus Virus in the Fruit Tree Pest Pyrops candelaria

Hong Lin, Weitao Song, Dongmei Ma, Chi Yang, Yanfang Yao, Renyi Liu, Ling Hao, Dandan Wu, Shihua Wang, Jimou Jiang, Jun Xiong, Rui Ma, Jiajing Xiao, Zhenhong Zhuang

Subject: Biology And Life Sciences, Insect Science Keywords: Iflavirus; Pyrops candelaria; virus; insect; distribution

Online: 14 June 2024 (16:08:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0789.v1

Molecular Identification and Prevalence of the Mite Carpoglyphus lactis (Acarina: Carpoglyphidae) in Apis mellifera in the Republic of Korea

Thi-Thu Nguyen, Mi-Sun Yoo, Hyang-Sim Lee, So Youn Youn, Se-Ji Lee, Su-Kyoung Seo, Jaemyung Kim, Yun Sang Cho

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Apis mellifera; Carpoglyphus lactis; Cytochrome c oxidase subunit 1 (COI) gene; Molecular identification; Republic of Korea

Online: 13 March 2024 (16:10:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1655.v1

Under Normoxia Simvastatin Shifts Lipid Metabolism of B16.F10 Melanoma Cells to Support Their Aggressiveness

Giorgiana Gabriela Negrea, Loredana Balacescu, Alina Sesarman, Manuela Banciu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: simvastatin; normoxia; hipoxia inducible factor 1; transcriptomics; unsaturated fatty acids; prostaglandins

Online: 23 September 2024 (08:45:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0203.v1

Molecular Cloning and Expression Analysis of COX II from Sitophilus zeamais, a Potential Action Site of AITC

Changliang Hou, Jingbo Wang, Hua Wu, Jiayu Liu, Zhiqing Ma, Juntao Feng, Xing Zhang

Subject: Biology And Life Sciences, Insect Science Keywords: Sitophilus zeamais; COXⅡ; Soluble proteins; Enzyme activity; AITC

Online: 25 August 2016 (10:11:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0130.v1

Interaction Solutions for the Fractional KdVSKR Equations in (1+1)-Dimension and (2+1)-Dimension

Lihua Zhang, Zitong Zheng, Bo Shen, Gangwei Wang, Zhenli Wang

Subject: Physical Sciences, Mathematical Physics Keywords: Korteweg-de Vries Sawada-Kotera-Ramani (KdVSKR) equation; extended Korteweg-deVries (KdV) equation; Sawada-Kotera (SK) equation; finite symmetry groups; Lie symmetry; exact solutions; consistent Riccati expansion (CRE); Hirota bilinear method; fractional derivatives

Online: 2 August 2024 (06:04:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0181.v1

Sustainable E-commerce: Blockchain and Channel Structure in Online Retail Platforms

Xunbo Wu, Wenqi Jiang, Lingjie Meng

Subject: Business, Economics And Management, Business And Management Keywords: sustainable E-commerce; blockchain technology; channel structure; online retail platform; counterfeit mitigation

Online: 2 July 2024 (05:27:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1359.v1

Anti-Herpetic Activity of Killer Peptide (KP): An In Vitro Study

Arianna Sala, Francesco Ricchi, Laura Giovati, Stefania Conti, Tecla Ciociola, Claudio Cermelli

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Antimicrobial peptides; HSV-1; HSV-2; antivirals; Killer Peptide (KP)

Online: 19 September 2024 (08:45:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0008.v3

Properties of the long-term oscillations in the middle atmosphere based on observations from TIMED/SABER

Yiyao Zhang, Shudao Zhou, Hanqing Shi, Zheng Sheng, Weilai Shi, Huadong Du, Zhiqiang Fan

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: AO; SAO; TO; amplitude; phase

Online: 6 October 2016 (08:52:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1028.v1

Biomaterials in Drug Delivery and Clinical Applications

Nadia Islam, Aiša Galijatović, Selma Kozarić, Adna Hrapović, Ajla Tipura, Boris Kovalenko, Maida Hajdarpašić, Asmaa Al Bourghli, Haris Lokvančić, Abas Sezer, Alaa A. Aljabali, Murtaza M. Tambuwala, Altijana Hromić-Jahjefendić, Vladimir N. Uversky

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: biomaterials; drug delivery; clinical applications; ethics

Online: 15 July 2024 (10:48:08 CEST)

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