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Preprint ARTICLE | doi:10.20944/preprints202306.1692.v1

The Fontanamare Discovery (Sardinia coast, Italy), A Case of Underwater Corrosion of Bronze Coins

Tilde De Caro, Fiammetta Susanna, Mauro Francesco La Russa, Andrea Macchia

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: bronze corrosion; submarine environment; Fontanamare wreck

Online: 23 June 2023 (14:37:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0998.v1

Palliative Care: The Italian State of the Art and a Worldwide Overview

Gianpietro Volonnino, Gianpiero D’Antonio, Cuomo Federica, Nicola Di Fazio, Raffaele La Russa, Mauro Arcangeli, Paola Frati

Subject: Medicine And Pharmacology, Other Keywords: Palliative Care; Bioethics; end of life; Law no. 38/2010

Online: 14 August 2023 (10:24:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0037.v1

Ovarian Cancer in the Era of Immune Checkpoint Inhibitors: State of the Art and Future Perspectives.

Brigida Anna Maiorano, Mauro Francesco Pio Maiorano, Domenica Lorusso, Evaristo Maiello

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ovarian cancer; checkpoint inhibitors; ICIs; immunotherapy; PARP; avelumab; pembrolizumab; nivolumab; bevacizumab; platinum

Online: 2 August 2021 (13:01:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1257.v1

Geoheritage and Cultural Heritage Interface in a Worship Place: The Case Study of the Monumental Complex of San Francesco Le Moniche in Aversa (XIII Century, Italy) and Its Underground Artificial Cavities

Daniela Ruberti, Maria Assunta Fabozzi, Paolo Maria Guarino, Ivana Guidone, Arcangelo Pellegrino, Marco Vigliotti

Subject: Environmental And Earth Sciences, Other Keywords: Campania Plain; Italy; Campania Grey Tuff; underground cavities; building-stone; architecture; historical heritage; geoheritage; historical cartography; multidisciplinary characterization

Online: 16 September 2024 (15:13:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0631.v1

Collaborative Monitoring of Plant Biodiversity and Research of Sweet Acorn Oaks within Paths of Knowledge and Sustainability Education

Antonino Soddu Pirellas, Mauro Ballero, Sebastiano Porcu, Giovanna Serra, Francesco Sanna, Michele Puxeddu

Subject: Environmental And Earth Sciences, Environmental Science Keywords: plant biodiversity; collaborative monitoring; paths of knowledge; Quercus ilex; habitat; Mediterranean diet; sustainability education

Online: 9 January 2024 (02:40:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0258.v2

Vive la Difference! Effects of Natural and Conventional Wines on the Blood Alcohol Concentrations: A Randomized, Triple-Blind Controlled Study

Federico Francesco Ferrero, Maurizio Fadda, Luca De Carli, Marco Barbetta, Rajandrea Sethi, Andrea Pezzana

Subject: Biology And Life Sciences, Food Science And Technology Keywords: alcohol; natural wine; blood alcohol content; breathalyzer; pesticides

Online: 4 April 2019 (11:23:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0784.v1

Dramatic Suppression of Lipogenesis and No Increase in Beta- Oxidation Are the Main Effects of Bergamot Flavonoids on Gene Expression in Fatty Liver Disease

Maddalena Parafati, Daniele La Russa, Antonella Lascala, Francesco Crupi, Concetta Riillo, Bartosz Fotschki, Vincenzo Mollace, Elzbieta Janda

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: flavonoids; hepatic steatosis; lipogenesis; Citrus Bergamia; gene profiling

Online: 11 April 2024 (09:32:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.2002.v1

Nuclear miRNAs: gene regulation activities

Monia Billi, Elisabetta De Marinis, Martina Gentile, Clara Nervi, Francesco Grignani

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: miRNAs, nuclear localization, gene regulation, transcriptional control, RNA processing, Haematopoiesis.

Online: 30 April 2024 (11:55:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0683.v1

Gamifying Cultural Heritage: The Digitization Journey of Genoa University Museum System (SMA-UniGe)

Lara La Tessa, Stefano Schiaparelli, Mauro Coccoli, Saverio Iacono, Gianni Vercelli, Daniele Zolezzi

Subject: Computer Science And Mathematics, Other Keywords: Digital Heritage; Gamification; User Experience

Online: 10 April 2024 (09:40:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1220.v1

Volatile Characterization of Recovery Minority Varieties from Castilla-La Mancha Region (Spain)

Cristina Cebrián-Tarancón, A.Sergio Serrano, Juan L. Chacón-Vozmediano, Jesús Martínez-Gascueña, Gonzalo L. Alonso

Subject: Biology And Life Sciences, Plant Sciences Keywords: recovered grapevine cultivars; aroma compounds; aroma potential; water stress

Online: 18 April 2024 (11:04:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0550.v1

Customizable Vector Acceleration in Extreme-Edge Computing: A RISC-V Software/Hardware Architecture Study on VGG-16 Implementation

Mauro Olivieri, Abdallah Cheikh, Francesco Menichelli, Antonio Mastrandrea, Stefano Sordillo

Subject: Engineering, Automotive Engineering Keywords: edge-computing; processors; hardware acceleration

Online: 27 January 2021 (09:59:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0006.v1

Castanea sativa Mill. Shells Aqueous Extract Exhibits Anticancer Properties Inducing Cytotoxic and Pro-apoptotic Effects

Nunzio Antonio Cacciola, Giuseppe Squillaci, Mariella D’Apolito, Orsolina Petillo, Francesco Veraldi, Francesco La Cara, Gianfranco Peluso, Sabrina Margarucci, Alessandra Morana

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: chestnut shells; polyphenols; bioactive compounds; apoptosis; cytotoxicity; human cell lines

Online: 1 August 2019 (04:37:49 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202005.0423.v2

SARS-CoV-2 Virion Stabilization by Zn Binding

Silvia Morante, Giovanni La Penna, Giancarlo C. Rossi, Francesco Stellato

Subject: Biology And Life Sciences, Biophysics Keywords: Sars-CoV2; Zn Finger; orf7a/orf8 and Theterin

Online: 9 August 2020 (22:08:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1666.v1

Radionuclides in Italian Drinking Water and Regulations: Data Collection to Improve Risk Assessment

Francesco Manna, Mariagabriella Pugliese, Fabrizio Ambrosino, Marco Trifuoggi, Antonella Giarra, Giuseppe La Verde

Subject: Physical Sciences, Applied Physics Keywords: environmental radioactivity; drinking water; regulation; monitoring; risk assessment; data analysis; Italy

Online: 23 August 2023 (12:53:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2115.v1

SARS-CoV-2-Specific CD8⁺ T Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after Infection

Flavia Ferrantelli, Francesco Manfredi, Chiara Chiozzini, Patrizia Leone, Katherina Pugliese, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Mauro Valeri, Andrea Cara, Zuleika Michelini, Mauro Andreotti, Maurizio Federico

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-CoV-2; CD8+ T cell immunity; vaccines; K18 transgenic mice

Online: 1 August 2023 (02:33:49 CEST)

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Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 enters the host by infecting nasal ciliated cells. Then, the virus can spread towards the oropharyngeal cavity and the pulmonary tissues. The antiviral adaptive immunity is promptly induced in response to virus detection, with virus-specific T lymphocytes appearing before antiviral antibodies. Both breadth and potency of the antiviral CD8+ T cell immunity have a key role in containing viral spread and disease severity. Current anti-SARS-CoV-2 vaccines do not impede the virus replication in the upper respiratory tract, and there is consensus on the fact that the best potency of the antiviral immune response in both blood and upper respiratory tract can be reached upon infection in vaccinees (i.e., breakthrough infection). However, whether the antiviral CD8+ T cells developing in response to the breakthrough infection in the upper respiratory tract diffuse to the lungs also is still largely unknown. To fill the gap, we checked the CD8+ T cell immunity elicited after infection of K18-hACE2 transgenic mice both 3 weeks and 3 months after anti-Spike vaccination. The virus-specific CD8+ T cell immunity was monitored in both blood and the lungs before and after infection. By investigating the de novo generation of CD8+ T cells specific for SARS-CoV-2 viral proteins, we found that both membrane (M) and/or nucleocapsid (N)-specific CD8+ T cells were induced at comparable levels in blood of both unvaccinated and vaccinated mice. Conversely, N-specific CD8+ T cells were readily found in the lungs of control mice, but were either rare or absent in those of vaccinated mice. These results support the idea that the hybrid cell immunity developing after asymptomatic/mild breakthrough infection strengthens the antiviral cell immunity at lungs only marginally, implying that the direct exposition of the viral antigens is required for the induction of an efficient antiviral cell immunity in the lungs.

Preprint ARTICLE | doi:10.20944/preprints202401.0298.v1

Comparison of PIV and Other Immune Inflammation Markers of Oncological and Survival Outcomes in Patients Undergoing Radical Cystectomy

Pierluigi Russo, Giuseppe Palermo, Roberto Iacovelli, Mauro Ragonese, Chiara Ciccarese, Giuseppe Maioriello, Fabrizio Fantasia, Francesco Pio Bizzarri, Filippo Marino, Seyed Koosha Moosavi, Domenico Nigro, Filippo Gavi, Giovanni Battista Filomena, Francesco Rossi, Francesco Pinto, Marco Racioppi, Nazario Foschi

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: urothelial carcinoma; inflammation; pan-immune inflammation value; radical cystectomy

Online: 4 January 2024 (15:17:24 CET)

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Inflammation is widely acknowledged as a significant characteristic of cancer, playing a substantial function in both the initiation and advancement of cancers. In this research, we planned to investigate the comparison among pan-immune inflammation markers and other well-known markers (systemic immune inflammation index and neutrophil to lymphocyte ratio) to predict prognosis in individuals treated with radical cystectomy for bladder cancer. Methods: In this retrospective analysis, we focused on preoperative PIV, systemic immune inflammation index (SII), and neutrophil-lymphocyte ratio (NLR) in 193 individuals managed with radical cystectomy for bladder cancer between January 2016 and November 2022. Multivariable logistic regression assessments were perfomred to assess the predictive capabilities of PIV, SII, and NLR for infiltration of lymph nodes (N), aggressive tumor stage (pT3/pT4), and any non-organ limited disease at the time of RC. Multivariable Cox regression analyses were conducted to assess the predictive impact of PIV on Relapse-free survival (RFS), Cancer-specific survival (CSS), and Overall survival (OS). Results: Our individuals were divided into high PIV and low PIV cohorts using the optimal cut-off value (340.96 x 109/ L) based on receiver operating characteristic curve analysis for relapse-free survival. In multivariable preoperative logistic regression models, only SII and PIV correlated with the infiltration of lymph nodes, aggressive disease, and any non-organ confined disease. In multivariable Cox regression models considering presurgical clinicopathological variables, an higher PIV was associated with diminished RFS (p = 0.017) and OS (p = 0.029). In addition, in multivariable Cox regression models for postoperative outcomes, a high PIV correlated with both RFS ( p = 0.034) and OS ( p= 0.048). Conclusions: Our study suggests that PIV and SII are two very similar markers that may serve as an independent and significant predictor of aggressive disease and worse survival impacts on individuals undergoing radical cystectomy for bladder neoplasm.

Preprint REVIEW | doi:10.20944/preprints202305.2022.v1

Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children

Giovanna Scorrano, Saverio La Bella, Sara Matricardi, Francesco Chiarelli, Cosimo Giannini

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Metabolic syndrome; obesity; neuroendocrine systems; stress response; genetic polymorphisms

Online: 30 May 2023 (02:27:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0951.v1

CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

David Sanchis-Pascual, María Isabel Del Olmo-García, Stefan Prado-Wohlwend, Carlos Zac, Ángel Segura Huerta, Javier Hernández-Gil, Luis Martí-Bonmatí, Juan F. Merino-Torres

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: CXCR4; CXCL12; cancer; neuroendocrine neoplasm; radiotracer

Online: 15 April 2024 (10:16:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0284.v1

Continuous Time Simulation and System Level Control Model of a Modern MVDC Distribution Grid including SST and MMC Based AFE

Daniel Siemaszko, Mauro Carpita

Subject: Engineering, Electrical And Electronic Engineering Keywords: DC distribution systems; Power systems simulation; Power distribution control; Power system planning,; Pulse Width Modulation; Modular Multilevel Converter (MMC); Solid State Transformer

Online: 3 April 2024 (10:00:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1351.v1

Deep Learning Based Geomorphic Features Identification in Dredge Pit Marine Environment

Wenqiang Zhang, Xiaobing Chen, Xiangwei Zhou, Jianhua Chen, Jianguo Yuan, Taibiao Zhao, Kehui Xu

Subject: Environmental And Earth Sciences, Oceanography Keywords: sidescan; sonar; geomorphology; deep learning; coastal restoration; EfficientNet

Online: 21 May 2024 (07:20:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0557.v1

Hourly Water Level Forecasting in an Hydroelectric Basin Using Spatial Interpolation and Artificial Intelligence

Mauro Tucci

Subject: Engineering, Electrical And Electronic Engineering Keywords: hydroelectric basin modelling; spatial interpolation; neural networks; Kriging

Online: 30 November 2022 (03:10:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.2073.v1

Development and Applications of Somatic Embryogenesis in Grapevine (Vitis spp.)

Angela Carra, Akila Wijerathna-Yapa, Ranjith Pathirana, Francesco Carimi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Germplasm; Mutagenesis; in vitro culture; Tissue culture; Micropropagation; Conservation; Somaclonal variation; Transformation; Chimera; Virus

Online: 29 August 2024 (08:49:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0235.v1

Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation

Mauro Di Ianni, Carmine Liberatore, Nicole Santoro, Paola Ranalli, Francesco Guardalupi, Giulia Corradi, Ida Villanova, Barbara Di Francesco, Stefano Lattanzio, Cecilia Passeri, Paola Lanuti, Patrizia Accorsi

Subject: Public Health And Healthcare, Primary Health Care Keywords: GvHD; GvL; TCR alpha-beta; CD45RA; Tregs; NK; Suicide gene; immunotherapies

Online: 5 December 2023 (09:18:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1235.v1

Microplastic Contamination in Commercial Insect Meal: A Valid Analytical Method to Detect It

Simona Rimoldi, Jessica Ponti, Andrea Valsesia, Giulio Saroglia, Rita La Spina, Francesco Fumagalli, Genciana Terova

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Aquaculture; Insect meal; Microplastics (MP); Nanoplastics (NP); Aquafeed; Raman microscopy; Transmission Electron Microscopy (TEM); Scanning Electron Microscope (SEM); Energy-dispersive X-ray spectroscopy (EDX); Fourier transform infrared (FTIR).

Online: 20 March 2024 (14:11:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1888.v1

Visual Data and Pattern Analysis for Smart Education: A Robust Drl-Based Early Warning System for Student Performance Prediction

Wala Bagunaid, Naveen Chilamkurti, Ahmad Salehi Shahraki, Saeed Bamashmos

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: E-FedCloud; Cycle General Adversarial Network (CGAN); Majority Voting-Based Multi-Objective Clustering (MV-MOC); Duelling Deep Q Network (ID2QN).

Online: 29 April 2024 (10:25:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0959.v1

Magnetic Prospecting as a Tool for the Characterization of Mining Dams in the La Carolina Mining District (South of Spain)

Rosendo Mendoza, Javier Rey, Jose Vílchez, M. Carmen Hidalgo

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Tailings dams; Environmental risk; Magnetometry; Magnetic susceptibility; La Carolina mining district; Spain

Online: 18 March 2024 (09:53:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.1401.v1

Antithrombotic Therapy in Patients Undergoing Transcatheter Aortic Valve Implantation

Francesco Pallante, Francesco Costa, Victoria Garcia Ruiz, Giampiero Vizzari, Pietro Iannello, Lucio Teresi, Gabriele Carciotto, Stefania Lo Giudice, Giustina Iuvara, Giulia Laterra, Ander Regueiro, Gennaro Giustino, Juan Horacio Alonso Briales, Jose Maria Hernandez, Marco Barbanti, Antonio Micari, Francesco Patanè

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Antithrombotic therapy; Aortic valve stenosis; Transcatheter Aortic Valve Implantation (TAVI); Transcatheter Aortic Valve Replacement (TAVR); bleeding risk; thrombotic risk; tailored therapy; risk scores.

Online: 21 May 2024 (14:02:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0762.v1

High-Throughput Drug Stability Assessment via Biomimetic Metalloporphyrin Catalyzed Reactions Using Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry (LA-REIMS)

András Marton, Zsombor Márton Mohácsi, Balázs Decsi, Balázs Csillag, Júlia Balogh, Richárd Schäffer, Tamás Karancsi, György Tibor Balogh

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: high-throughput screening; metabolic stability; ambient mass spectrometry; LA-REIMS; biomimetic metalloporphyrin; lead profiling; in vitro models; drug metabolism

Online: 12 June 2024 (14:15:32 CEST)

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Working Paper REVIEW

Impact of El Niño and La Niña on Agriculture in Ethiopia: Implications for El Niño and La Niña Adaptation and Food Security in Ethiopia

Abadi Berhane, Teklay Tesfay

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: El Niño; La Niña; statistical indices; climate change adaptation; Ethiopia

Online: 3 September 2020 (15:33:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0804.v1

Results of Tendon Transfers in Radial Nerve Palsies: A New Evaluation Protocol

Micaela Reina, Simonetta Odella, Mauro Magnani, Francesco Locatelli, Alice Clemente, Martina Macrì, Pierluigi Tos

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: periferal nerve injuries, radial palsy, tendon transfer, protocol in nerve palsy

Online: 12 June 2024 (09:31:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1156.v1

Is Mild Really Mild?”: Generating Longitudinal Profiles of Stroke Survivor Impairment and Impact Using Unsupervised Machine Learning

Achini Adikari, Rashmika Nawaratne, Daswin De Silva, David Carey, Alistair Walsh, Carolyn Baum, Stephen Davis, Geoffrey A. Donnan, Damminda (PhD), Leeanne M Carey

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: mild stroke; artificial intelligence; patient profiling; unsupervised learning; personalized healthcare

Online: 15 July 2024 (11:31:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0501.v1

Exploring Regorafenib Responsiveness and Uncovering Molecular Mechanisms in Recurrent Glioblastoma Tumors Through Longitudinal In Vitro Sampling

Mariangela Morelli, Francesca Lessi, Sara Franceschi, Gianmarco Ferri, Manuel Giacomarra, Michele Menicagli, Carlo Gambacciani, Francesco Pieri, Francesco Pasqualetti, Nicola Montemurro, Paolo Aretini, Orazio Santo Santonocito, Anna Luisa Di Stefano, Chiara Maria Mazzanti

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Glioblastoma; NADP(H) FLIM; Regorafenib; drug response; organoids

Online: 8 February 2024 (14:13:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0245.v1

Atmospheric and ionospheric effects of La Palma volcano 2021 eruption

Hanshuo Zhang, Kaiguang Zhu, Yuqi Cheng, Dedalo Marchetti, Wenqi Chen, Mengxuan Fan, Siyu Wang, Ting Wang, Donghua Zhang, Yiqun Zhang

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: La Palma; volcano eruption; lithosphere; atmosphere; ionosphere; AGW; LAIC

Online: 4 July 2023 (14:02:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0986.v1

A Low Cost Early Warning Method for Infectious Diseases with Asymptomatic Carriers

Mauro Gaspari

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; test positivity rate; early wa; health system management

Online: 12 January 2024 (09:03:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.0425.v1

Mapping and Omics Integration: Towards Precise Rice Disease Resistance Breeding

John Christian Ontoy, Jong Hyun Ham

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Oryza sativa; disease resistance; QTL mapping; omics; integrative approach

Online: 5 April 2024 (15:01:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0993.v1

Total phenolics, oxygen radical absorbance capacity, color and microstructure of walnut and hazelnut shells by-products from southern Chile agro-industry

Carlos Manterola-Barroso, Karina Godoy Sánchez, Erick Scheuermann, Daniela Padilla-Contreras, Filis Morina, Cristian Meriño-Gergichevich

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Hard-shelled seeds; Nutshells; Shell features; Valued material; Waste material.

Online: 14 June 2024 (09:55:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0116.v1

Newborn Care in the Home and Health Facility: Formative Findings for Intervention Research in Cambodia

Alessandra N. Bazzano, Leah D. Taub, Richard Oberhelman, Chivorn Var

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Neonate; qualitative research; Southeast Asia

Online: 29 September 2016 (11:17:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0053.v1

Chemical Characterization and Evaluation of the Antimicrobial Activity of Extracts from Two Cultivars of Cannabis sativa L. (Tisza and Kompolti) Grown in Sardinia

Claudia C.A. Juliano, Ivana Mattu, Mauro Marchetti, Marianna Usai

Subject: Chemistry And Materials Science, Other Keywords: Cannabis sativa L.; Tisza; Kompolti; essential oils; resins; antimicrobial activity

Online: 1 March 2024 (14:40:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.1370.v1

Mycologists and Virologists Align: Proposing Botrytis cinerea for Global Mycovirus Study

Mahmoud E. Khalifa, María A Ayllón, Lorena Rodriguez-Coy, Kim M Plummer, Anthony R Gendall, Kar Mun Chooi, Jan A.L. van Kan, Robin M MacDiarmid

Subject: Biology And Life Sciences, Virology Keywords: model system; Botrytis cinerea; mycovirus

Online: 21 August 2024 (02:28:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0661.v1

Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Antonio Salsano, Michele Di Mauro, Laura Labate, Alessandro Della Corte, Federica Lo Presti, Michele De Bonis, Cinzia Trumello, Mauro Rinaldi, Erik Cura Stura, Guglielmo Actis Dato, Giuseppe Punta, Francesco Nicolini, Davide Carino, Carlo De Vincentiis, Andrea Garatti, Giangiuseppe Cappabianca, Andrea M Musazzi, Diego Cugola, Maurizio Merlo, Davide Pacini, Gianluca Folesani, Sandro Sponga, Igor Vendramin, Alberto Pilozzi Casado, Francesco Rosato, Elisa Mikus, Carlo Savini, Francesco Onorati, Giovanni Battista Luciani, Roberto Scrofani, Francesco Epifani, Francesco Musumeci, Antonio Lio, Andrea Colli, Giosuè Falcetta, Salvatore Nicolardi, Salvatore Zaccaria, Enrico Vizzardi, Antonio Pantaleo, Giuseppe Minniti, Emmanuel Villa, Margherita Dalla Tomba, Francesco Pollari, Fabio Barili, Alessandro Parolari, Roberto Lorusso, Francesco Santini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: endocarditis; aortic valve replacement; prosthetic heart valve.

Online: 9 November 2023 (15:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1751.v1

Optimizing Milling Parameters for Enhanced Machinability of 3D‐Printed Materials: An Analysis of PLA, PETG, and Carbon Fiber Reinforced PETG

Mohamad El Mehtedi, Pasquale Buonadonna, Rayane El Mohtadi, Gabriela Loi, Francesco Aymerich, Mauro Carta

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: 3D printing; PLA; PETG; CF-PETG; milling; burr formation; roughness; ANOVA analysis

Online: 27 May 2024 (12:08:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1583.v1

The Shortening of Leukocyte Telomere Length Contributes to Alzheimer’s Disease: Further Evidence from Late-Onset Familial and Sporadic Cases

Paolina Crocco, Francesco De Rango, Serena Dato, Rossella La Grotta, Raffaele Maletta, Amalia Cecilia Bruni, Giuseppe Passarino, Giuseppina Rose

Subject: Biology And Life Sciences, Aging Keywords: Telomere length; Telomeres; Alzheimer’s Disease; late-onset AD, Aging, Neurodegeneration

Online: 22 August 2023 (13:22:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0053.v2

Enantioselective Transamination in Continuous Flow Mode with Transaminase Immobilized in a Macrocellular Silica Monolith

Ludivine van den Biggelaar, Patrice Soumillion, Damien P. Debecker

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: chiral amines; biocatalysis; silica monolith; enzyme immobilization; flow chemistry

Online: 13 February 2017 (09:02:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201708.0034.v1

Overview of Modelling and Control Strategies for Wind Turbines and Hydroelectric Systems: Comparisons and Contrasts

Silvio Simani, Stefano Alvisi, Mauro Venturini

Subject: Engineering, Control And Systems Engineering Keywords: wind turbines; hydroelectric systems; nonlinear modelling; model--based control; data--driven approach; advanced control; robustness and reliability

Online: 9 August 2017 (04:42:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1625.v1

Guardians Under Siege: Exploring Pollution's effects on Human Immunity

Gaspare Drago, Noemi Aloi, Silvia Ruggieri, Alessandra Longo, Maria Lia Contrino, Fabio Massimo Contarino, Fabio Cibella, Paolo Colombo, Valeria Longo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Environmental pollutant; innate and adaptive immunity; immunomodulation; developmental toxicology; pregnancy

Online: 24 June 2024 (12:30:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1196.v1

Power Consumption Modeling of Airconditioning Units in an Educational Building Using Polynomial and Neural Network Fitting Techniques

Stanley Glenn Brucal, Aaron Don Africa, Roy Francis Navea, Ana Antoniette Illahi, Aristotle Ubando, Marla Maniquiz-Redillas, Reggie Gustilo, Pocholo James Loresco

Subject: Engineering, Electrical And Electronic Engineering Keywords: power modeling; curve fitting; neural network fitting; regression analysis; power stabilization; thermal condition; indoor air quality

Online: 20 March 2024 (09:50:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0744.v1

Influence of Glycerol on the Surface Morphology and Crystallinity of Polyvinyl Alcohol Films

Ganna Kovtun, David Casas, Teresa Cuberes

Subject: Chemistry And Materials Science, Nanotechnology Keywords: polyvinyl alcohol films pva/glycerol blends; crystallinity; infrared spectroscopy; x-ray diffraction; thermogravimetry; differential thermal analysis; atomic force microscopy; lateral force microscopy; ultrasonic force microscopy

Online: 12 June 2024 (14:07:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0806.v1

Active Surveillance in the Management of Ductal Carcinoma in Situ: The Radiologist’s Point of View

Luca Nicosia, Giuseppe di Giulio, Anna Carla Bozzini, Marianna Fanizza, Francesco Ballati, Anna Rotili, Matteo Lazzeroni, Antuono Latronico, Francesca Abbate, Giuseppe Renne, Francesca Addante, Marco Lucioni, Enrico Cassano, and Mauro Giuseppe Mastropasqua

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Ductal carcinoma in situ (DCIS); Invasive Breast Carcinoma; Underestimation; Upgrade Rate; Vacuum assisted breast biopsy (VABB); Breast Microcalcifications; Active Surveillance.

Online: 31 December 2020 (12:52:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.1809.v1

Advanced Omics Techniques for Understanding Cochlear Genome, Epigenome and Transcriptome in Health and Disease

Annamaria Tisi, Sakthimala Palaniappan, Mauro Maccarrone

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Omics, Cochlea, Single cell omics, Spatial omics, Epigenomics, Transcriptomics, Genomics, Organ of Corti.

Online: 25 August 2023 (13:29:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1451.v1

Rethinking Public Participation in Forest Policies: A Literature Review of Participatory Techniques

Isabella De Meo, Alessandro Paletto, Sofia Baldessari

Subject: Environmental And Earth Sciences, Environmental Science Keywords: participatory democracy; citizen involvement; decision making; inclusiveness; degree of in-volvement

Online: 17 July 2024 (14:01:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1424.v1

Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance

Osvaldo Inostroza, Paulina Yáñez, Giovanni Espinoza, Omar Fica, Camila Queraltó, José Rodríguez, Isidora Flores, Ruth González, Jorge A Soto, Juan A Fuentes, Iván L Calderón, Fernando Gil

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Clostridiodes difficile; Persisster cells; Antibiotic tolerance

Online: 20 June 2024 (14:46:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0073.v1

Gaseous Elemental Mercury and Total and Leached Mercury in Building Materials from the Former Hg-Mining Area of Abbadia San Salvatore (Central Italy)

Orlando Vaselli, Barbara Nisi, Daniele Rappuoli, Jacopo Cabassi, Franco Tassi

Subject: Environmental And Earth Sciences, Environmental Science Keywords: gaseous elemental mercury; hg-mining areas; abbadia san salvatore; central italy; total and leached mercury; building material; remediation

Online: 14 March 2017 (07:57:35 CET)

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Mercury has a strong environmental impact since both its organic and inorganic forms are toxic and it represents a pollutant of global concern. Liquid Hg is highly volatile and it can be released during natural and anthropogenic processes in the hydrosphere, biosphere and atmosphere. In this study the distribution of Gaseous Elemental Mercury (GEM) and the total and leached mercury concentrations on paints, plasters, roof tiles, concretes, metals, dust and wood structures were determined in the main buildings and structures of the former Hg-mining area of Abbadia San Salvatore (Siena, Central Italy). The mining complex (divided into 7 units) covers a surface of about 65 ha and contains mining structures and managers and workers buildings. In this work, nine surveys of GEM measurements were carried out from July 2011 to August 2015 for the buildings and structures located in the units 2, 3 and 6. Moreover, detailed measurements were performed in February, April, July, September and December 2016 in the edifices and mining structures of Unit 6. GEM concentrations showed a strong variability in terms of space and time mostly depending on the distance from the building hosting driers, furnaces and condensers and ambient temperature, respectively. In the Unit 2 surveys carried out in the hotter period (from June to September) showed GEM concentrations up to 27,500 ng m⁻³, while in the Unit 6 they were on average much higher and occasionally they saturated the GEM measurement device (>50,000 ng m⁻³). Concentrations of total (in mg kg⁻¹) and leached (in μg L⁻¹) mercury measured in different building materials (up to 46,580 mg kg⁻¹ and 4,470 mg L⁻¹ for total and leached mercury, respectively) showed for the same type of material highly variable values in dependence on the edifice or mining structure from which they were collected. The results obtained in this study are of relevant interest for the operational cleanings to be carried out during the reclamation activities.

Preprint ARTICLE | doi:10.20944/preprints201701.0073.v1

Food as Commons or Commodity? Exploring the Links between Normative Valuations and Agency in Food Transition

Jose Luis Vivero-Pol

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: food valuation; food as commons; food as commodity; transition theory; narratives of transition; agency in transition; transformative agency; counter-hegemonic attitudes; gradual reformers

Online: 16 January 2017 (04:17:20 CET)

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The food system, the most important driver of planetary transformation, is in a deep crisis. Therefore, seeking a sustainable and socially-fair transition pathway becomes an issue of utmost priority for our own survival. The consideration of food as a commodity, a social construct that played a central role in driving this crisis, remains the uncontested narrative to lead the different transition pathways what seems rather contradictory. By exploring the normative values in the transition landscape, this paper seeks to understand how relevant is the hegemonic narrative of “food as commodity” and its alternative of “food as commons” to determine transition trajectories and food policy beliefs. Applying the Multi-level Perspective framework and developing the ill-studied “agency in transition”, this research enquired food-related professionals that belong to an online community of practice (N=95) on valuation of food dimensions and agency in food transitions to check whether the valuation of food is relevant to explain personal stances in transition. Results suggest the socially-constructed view of food as commodity is positively correlated to the gradual reforming attitude, whereas food as commons is positively correlated to the counter-hegemonic transformers regardless the self-defined position in the transition landscape (regime or niches). At personal level, there are multiple loci of resistance with counter-hegemonic attitudes in varied institutions of the regime and the innovative niches, many of them holding this discourse of food as commons. Conversely, alter-hegemonic attitudes are not positively correlated to this alternative discourse and they may inadvertently or purportedly reinforce the ‘‘neoliberal narrative’’. Food as commons, a different narrative whose rationale is explained in the paper, seems to be a relevant framework that could enrich the multiple transformative constituencies that challenge the industrial food system and therefore facilitate the convergence of movements that reject the commodification of food.

Preprint ARTICLE | doi:10.20944/preprints202407.2468.v1

Cardiovascular Risk in Chinese Immigrants in the Colombian Caribbean Region

Lin Tan Kuang, Kevin Castro Márquez, Alberto Cadena Bonfanti, Andrés Cadena-Bonfanti, Alex Domínguez Vargas, Henry J. González-Torres

Subject: Public Health And Healthcare, Primary Health Care Keywords: Cardiovascular; Chinese; Immigrants; Lifestyles; Caribbean Region Colombian

Online: 30 July 2024 (23:56:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0669.v1

Petrophysical and Mechanical Properties of the Piromafo Stone Used in the Built Heritage of Apulia (SE Italy): A Comprehensive Laboratory Study

Gioacchino Francesco Andriani

Subject: Environmental And Earth Sciences, Other Keywords: Pietra Leccese; fabric; hydraulic behaviour; thermal properties; strength; weathering

Online: 11 June 2024 (10:17:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0731.v1

Street Guide as a Literary Genre: La Manada City

María del Mar López-Cabrales, Ioseph Cabeza-Lainez, Inmaculada Rodriguez-Cunill

Subject: Arts And Humanities, Art Keywords: urbanism; surrealism; literary devices; maps and plans; cities; gender; painting; architecture; literary genre; poetry.

Online: 23 April 2023 (02:43:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0226.v1

AI-Powered Educational Data Analysis for Early Identification of Learning Difficulties

Chun Wang, Jianke Zou, Ziyang Xie

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Early Identification of Learning Difficulties; Artificial Intelligence in Education; Personalized Learning Paths; Real-time Feedback Systems

Online: 6 August 2024 (05:15:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0572.v1

Self--Tuning Control Techniques for Wind Turbine and Hydroelectric Plant Systems

Silvio Simani, Stefano Alvisi, Mauro Venturini

Subject: Engineering, Control And Systems Engineering Keywords: wind turbine system; hydroelectric plant simulator; model--based control; data--driven approach; self--tuning control; robustness and reliability

Online: 24 October 2018 (11:26:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1683.v1

Central Actions of Leptin Induce an Atrophic Pattern and Improves Heart Function in Lean Normoleptinemic Rats via PPARβ/δ Activation

Blanca Rubio, Cristina Pintado, Lorena Mazuecos, Marina Benito, Antonio Andrés, Nilda Gallardo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: PPARβ /δ ; leptin; MRI; cardiac remodeling; Wistar rat

Online: 24 June 2024 (12:03:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1930.v1

Phytochemical Analysis on the Female Cone of Araucaria bidwillii Hook

Claudio Frezza, Alessandro Venditti, Ottavia Giampaoli, Chiara Dal Bosco, Marco Franceschin, Claudio Scintu, Fabio Sciubba, Mauro Serafini, Daniela De Vita, Fabio Attorre

Subject: Biology And Life Sciences, Plant Sciences Keywords: Araucaria bidwillii Hook; female cone; Central Italy; phytochemical analysis; chemophenetic analysis

Online: 24 July 2024 (12:03:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1527.v1

Visions and Paradigms of Transport and Cities

Francesco Filippi

Subject: Engineering, Transportation Science And Technology Keywords: behaviour; evolutionary psychology; public health; land use; mobility; transport; cities; sustainability; urban planning

Online: 26 March 2024 (07:30:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0053.v1

The Trend of Scientific Productivity of Chinese, European Union and United States Universities and Private Companies: Does the Future Belong to E-Technology Companies?

Mauro Giovanni Carta, Matthias Angermeyer, Silvano Tagliagambe

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Scientific Productivity; Universities; Private Companies; USA; European Union; China; Innivation; Reseach; Societal

Online: 2 March 2021 (09:24:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0267.v1

Data–Driven Control Techniques for Renewable Energy Conversion Systems: Wind Turbine and Hydroelectric Plants

Silvio Simani, Stefano Alvisi, Mauro Venturini

Subject: Engineering, Control And Systems Engineering Keywords: wind turbine system; hydroelectric plant simulator; model--based control; data–driven approach; self–tuning control; robustness and reliability

Online: 26 January 2019 (10:08:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0932.v1

Unbound Low-Energy Nucleons As Semiclassical Quantum Networks

Steven Charles Verrall, Andrew Kaminsky, Kori Noelle Verrall, Isaac Ozolins, Emily Friederick, Andrew Otto, Peter Lynch, Kelly Susan Verrall, Ivan Ngian, Reagen McCormick, Pearl Scallon, Seth Schaffer, Stephanie San Juan

Subject: Physical Sciences, Theoretical Physics Keywords: nucleon g-factor; Möbius band; fine-structure constant; quark charges; quark masses; W boson mass; proton charge radius; energetic causal sets; circular Unruh effect; intrinsic charm quarks

Online: 14 May 2024 (09:57:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1404.v1

Investigating the Effectiveness of Brexpiprazole in Schizophrenic Patients with Concurrent Alcohol and Substance Use Disorder: A Prospective, Multicentric, Real-World Study

Stefania Chiappini, Clara Cavallotto, Alessio Mosca, Francesco Di carlo, Tommaso Piro, Chiara Lorenzini, Maria pia Di paolo, Maria Pepe, Marco Di nicola, Valerio Ricci, Mauro Pettorruso, Giovanni Martinotti

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: dual disorders; substance use disorder; brexpiprazole; real-world study; addiction; substance-induce-psychosis.

Online: 18 January 2024 (14:03:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1530.v4

Network Inference from Cancer and Epithelial Cell Co-Culture Reveal Microenvironmental Configurations That Drives Population Dynamics

Alexandre S. Queiroga, Mauro Cesar Cafundó Morais, Beatriz Stransky

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: cells co-culture; population dynamic; cellular automata; boolean network; basin of attraction

Online: 7 November 2023 (12:50:45 CET)

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Human keratinocytes and melanoma can stick together to form clusters after eight days in co-culture. As in dynamic system concepts, one can consider cluster formation as the system attractor, cell seeding as the initial condition, and density change over time as a path within the basin of attraction. Herein, Cellular Automata, which is a class of Agent-Based Models, and Boolean Networks are discrete modeling methods used in population dynamics such that running the dynamics of cellular automata backward reveals an underlying network in terms of basin of attraction, also known as global dynamics. Thus, we hypothesize that one can estimate the local dynamic of an agent-based model from the basin of attraction of a boolean network. Here, we propose an approach to estimating these agent-based model rules, which consists of comparing the density states within each state transition and reaching a consensus among state transitions belonging to a basin of attraction of a boolean network. The objectives of this study are: (1) to infer a boolean network from the co-culture growth curve; (2) to estimate the rules of agent-based models; and (3) to implement spatial dynamics simulations. The binarization of the growth curve shows high population density after four days; the estimated agent-based model rules were compatible with cell proliferation and migration in agreement with literature, so we had to propose individual rules for survival and death. Spatial dynamics shows that (1) keratinocytes exhibit a higher density in neighborhoods where melanoma is present; (2) the chance of keratinocyte migration increases until the fourth day, then decreases, and the probability of survival increases substantially after four days; and (3) cells with low proliferation capacity die and free space for those with high ones. Our approach suggests that the attractor state of cell co-culture is induced mainly by an increase in keratinocyte migration and survival. Our approach has the potential to offer valuable clues about microenvironmental interactions or configurations that drive population dynamics.

Preprint ARTICLE | doi:10.20944/preprints202107.0156.v1

ACTonFood. Acceptance and Commitment Therapy-Based Group Treatment Compared to Cognitive Behavioral Therapy-Based Group Treatment for Weight Maintenance: An Individually Randomized Group Treatment Trial

Roberto Cattivelli, Anna Guerrini Usubini, Gian Mauro Manzoni, Francesco Vailati Riboni, Giada Pietrabissa, Alessandro Musetti, Christian Franceschini, Giorgia Varallo, Chiara A.M. Spatola, Emanuele Giusti, Gianluca Castelnuovo, Enrico Molinari

Subject: Social Sciences, Psychology Keywords: obesity; obesity rehabilitation; weight maintenance; eating disorders; Acceptance and Commitment Therapy; Cognitive Behavioral Therapy; Clinical Psychology

Online: 6 July 2021 (13:38:20 CEST)

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The purpose of this Individually Randomized Group Treatment Trial was to compare an Acceptance and Commitment Therapy-based (ACT) group intervention and a Cog-nitive Behavioral Therapy-based (CBT) group intervention for weight loss maintenance in a sample of adult patients with obesity seeking treatment for weight loss. 155 over-weight adults (BMI: Kg/m2= 43.8[6.8]) attending a multidisciplinary rehabilitation program for weight loss were randomized into two conditions: ACT and CBT. Demo-graphical, physical, and clinical data were assessed at the beginning of the program (t0), at discharge (t1), and at 6-month follow-up (t2). The following measures were ad-ministered: The Acceptance and Action Questionnaire-II (AAQ-II) and the Clinical Outcome in Routine Evaluation-Outcome Measure (CORE-OM). Generalized linear mixed models were performed to assess differences between groups. Moderation ef-fects for gender and eating disorders (ED) have been considered. From baseline to dis-charge no significant differences between interventions were found, with the only ex-ception of an improvement in the CORE-OM total score and in the CORE-OM subjective well-being subscale for those in the CBT condition. From discharge to follow-up ACT group participants showed significant results in terms of weight loss maintenance, CORE-OM total score, and CORE-OM and AAQ-II’s wellbeing, symptoms, and psy-chological problems subscales. Gender moderated the effects of time and intervention on the CORE-OM’ subscale reporting the risk for self-harm or harm others. The pres-ence of an eating disorder moderated the effect of time and intervention on the CORE-OM total score, on the CORE-Om’ symptoms and psychological problems sub-scales, and on the AAQ-II. Patients who received the ACT intervention were more likely to achieve a ≥5% weight loss from baseline to follow-up and to maintain the weight loss after discharge. The ACT intervention was thus effective in maintaining weight loss over time.

Preprint ARTICLE | doi:10.20944/preprints202407.0672.v1

Adsorption Technology For PFAS Removal In Water: Comparison Between Novel Carbonaceous Materials

Marco Petrangeli Papini, Marta Senofonte, Riccardo Cuzzola, Rania Remmani, Ida Pettiti, Carmela Riccardi, Giulia Simonetti

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: PFAS; water treatments; adsorption technology; pinewood biochar; date seeds biochar

Online: 9 July 2024 (12:28:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0577.v1

Novel ATP2A2 Gene Mutation c.118G>A Causing Keratinocyte and Cardiomyocyte Disconnection in Darier Disease

Andrea Frustaci, Alessandro De Luca, Romina Verardo, Valentina Guida, Maria Alfarano, Camilla Calvieri, Matteo Antonio Russo, Cristina Chimenti

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Darier disease; Gene Mutation; SERCA2; cardiomyocyte disconnection

Online: 11 March 2024 (09:41:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2174.v1

A Device for Controlling the Chlorination in Small Umbrian Water Distribution Systems

Francesco Casinini, Marco Ferrante

Subject: Engineering, Civil Engineering Keywords: water supply; chlorination; low-cost device

Online: 29 August 2024 (17:31:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0275.v1

Development of a 3D WebGIS Application for the Visualization of Seismic Risk on Infrastructural Work

Mauro Mazzei, Davide Quaroni

Subject: Engineering, Civil Engineering Keywords: web-GIS 3d; Seismic Analysis; Structural Analysis; FEA/FEM Analysis; OpenSees.

Online: 16 November 2021 (08:44:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0182.v1

Development of Coffee Biochar Filler for the Production of Electrical Conductive Reinforced Plastic

Mauro Giorcelli, Mattia Bartoli

Subject: Chemistry And Materials Science, Biomaterials Keywords: electrical properties; mechanical properties; recycling, epoxy resin

Online: 16 October 2019 (09:37:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1907.v1

Assessment of Pharmacological Adherence Using Mobile Applications in Chronic Obstructive Pulmonary Disease: A Scoping Review

Belen Machado, Pamela Quimbaya, Rosa-Helena Bustos, Diego Jaimes, Katherinne Cortes Palacio, Daniela Vargas, Laura Perdomo

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: medication adherence; pharmacological adherence; chronic obstructive pulmonary disease; mHealth; mobile applications

Online: 24 July 2024 (12:27:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0524.v1

Machine Learning Approaches for Inverse Problems and Optimal Design in Electromagnetism

Alessandro Formisano, Mauro Tucci

Subject: Engineering, Electrical And Electronic Engineering Keywords: Machine Learning; Magnetic Field Analysis; Optimal Design, Inverse Problems.

Online: 8 February 2024 (13:48:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0191.v1

Dipping Tidal Notches (DTN): Exposed vs Sheltered Morphometry

Stefano Furlani, Mauro Agate, Eleonora de Sabata, Renato Chemello, Valeria Vaccher, Giulia Visconti, Fabrizio Antonioli

Subject: Environmental And Earth Sciences, Geography Keywords: Coastal landforms; Rock coast geomorphology; Mediterranean Sea; Tidal notches; Sea level markers

Online: 2 April 2024 (10:26:14 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.2094.v1

Detection of Mesothelial-to-Mesenchymal Transition-Derived Carcinoma-Associated Fibroblasts in Primary Ovarian Carcinomas

Henar Tomero-Sanz, José Antonio Jiménez-Heffernan, María Concepción Fernández-Chacón, Ignacio Cristóbal-García, Ricardo Sainz de la Cuesta, Lucía González-Cortijo, Manuel López-Cabrera, Pilar Sandoval

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Ovarian cancer; primary tumor; mesothelial cells; carcinoma-associated fibroblasts; mesothelial-to-mesenchymal transition

Online: 31 May 2024 (08:10:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0106.v1

Urinary Elimination of Ecdysterone and its Metabolites following a Single-Dose Administration in Humans

Gabriella Ambrosio, Tasha Yuliandra, Bernhard Wuest, Monica Mazzarino, Xavier de la Torre, Francesco Botrè, Patrick Diel, Eduard Isenmann, Maria Kristina Parr

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: ecdysterone; metabolites; excretion profile; urinary pharmacokinetics

Online: 6 May 2021 (15:20:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0620.v1

The Paradox between Health and Work of the Metallurgical Complex in La Oroya

Israel Mallma Perez, Lita Salazar Vásquez

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Doe Run Peru; socioeconomic policy; public health; systemic freedom; La Oroya

Online: 26 May 2021 (08:02:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1492.v1

Ceftazidime-Avibactam Use in a Cohort of Children with Complex Chronic Conditions: Effectiveness and Absence of Resistance Development Following Difficult-to-Treat or Recurrent Infections

Miguel García-Boyano, María Alós Díez, Lorena Fernández Tomé, Luis Escosa-García, Francisco Moreno Ramos, Cristina Schuffelmann-Gutiérrez, Emilio Cendejas Bueno, Cristina Calvo, Fernando Baquero-Artigao, Esteban Frauca Remacha

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: ceftazidime-avibactam; carbapenem-resistant enterobacteriaceae; beta-lactamase OXA-48; Klebsiella pneumoniae; child; liver transplantation; intraabdominal infections; cholangitis

Online: 23 May 2024 (07:18:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0389.v1

Brain Ultrasonography in Critically Ill Septic Patients: A Scoping Review

Giada Cucciolini, Irene Corda, Francesco Forfori, Francesco Corradi

Subject: Medicine And Pharmacology, Other Keywords: Brain ultrasound; TCCS; transcranial doppler; sepsis; multimodal monitoring; POCUS

Online: 5 September 2024 (12:39:56 CEST)

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Introduction Sepsis-associated encephalopathy (SAE) is common in sepsis and is linked to high mortality and impaired neurologic outcome. Brain ultrasonography (US), including transcranial Doppler (TCD) and transcranial color-coded duplex sonography (TCCS), is a non-invasive tool for cerebral monitoring and might be useful in sepsis. The aims of this review are: 1) to explore whether brain perfusion is altered in sepsis, 2) to determine the role of brain US in guiding resuscitation, and 3) its ability to predict neurological outcomes in septic patients. Materials and methods This scoping review adhered to the PRISMA-ScR protocol and JBI methodology. A comprehensive literature search was conducted across MEDLINE, Scopus, and Web of Science. The review included studies on adults with sepsis or septic shock in the ICU. Randomised controlled trials, clinical trials, observational studies and systematic reviews were included. All the data related to the review's key questions were extracted and charted independently by two authors. Results 625 articles were screened, and 34 were ultimately included after application of exclusion criteria. 85% of the studies were observational 15% were systematic reviews with or without meta-analysis. The studies primarily focused on cerebral blood flow (CBF) alterations in sepsis, reporting variable results. Findings showed variable cerebral autoregulation (CAR) impairment, with higher incidence in the early stages of sepsis and associations with poor neurological outcomes. However, while alterations in CAR and CBF are common in septic patients, their impact on neurological outcomes and mortality is not clear. Regarding resuscitation, only a paucity of studies were found and no conclusions can be drawn. Conclusions The current body of evidence has a poor grade, but it is possible to say that brain US can identify cerebral perfusions alterations. Its usage during resuscitation is feasible and warrants further investigations. Use of brain US during resuscitation and for prediction of outcome is not currently supported by evidence. Further studies on brain perfusion, acquisition of 2D images of parenchyma (TCCS) and application of a multimodal brain monitoring might be useful in these contexts.

Preprint ARTICLE | doi:10.20944/preprints202405.1898.v1

Intertwining Between Temperature, Amount of Mixture, and Particle Number, in a Paradigmatic Many-Fermion Problem

Diana Monteoliva, Angelo Plastino, Angel Ricardo Plastino

Subject: Physical Sciences, Mathematical Physics Keywords: Likpin model; many fermion systems; mixture-degree; finite temperature; SU2 symmetrys

Online: 29 May 2024 (07:28:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1330.v1

Preoperative Accuracy of Acetabular Bone Defect Assessment in Complex Hip Revision Arthroplasty Based on 3D Life‐Sized Model: A Case Series

Francesco La Camera, Alessandro Pisano, Carlo Maria Favazzi, Edoardo Guazzoni, Vincenzo Di Matteo, Emanuela Morenghi, Guido Grappiolo, Mattia Loppini

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Revision total hip arthroplasties; complex acetabular reconstruction; preoperative planning; 3D printed models

Online: 21 November 2023 (13:21:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0672.v1

Citation review of Human-Machine Collaboration in Virtual Reality for Adaptive Production Engineering by de Giorgio et al.

Andrea de Giorgio, Mauro Onori

Subject: Engineering, Automotive Engineering Keywords: Virtual Reality; Simulation; Industry 4.0; Human-Robot Collaboration; Citation Review; Citation Metrics

Online: 26 November 2020 (11:26:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1747.v1

The ZIKV NS5 Protein Aberrantly Alters the Tubulin Cytoskeleton, Induces the Accumulation of Autophagic p62 and Affects IFN Production: HDAC6 Has Emerged as an Anti-NS5/ZIKV Factor

Silvia Pérez-Yanes, Iria Lorenzo-Sánchez, Romina Cabrera-Rodríguez, Jonay García-Luis, Rodrigo Trujillo-González, Judith Estévez-Herrera, Agustín Valenzuela-Fernández

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: ZIKV; NS5; aberrant MTs; MT acetylation; autophagic p62; HDAC6; tubulin deacetylase; BUZ domain; NS5 clearance; inhibition of IFN production

Online: 29 February 2024 (20:03:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0447.v1

Urinary Excretion Kinetics of Salbutamol and Its Sulfoconjugated Main Metabolite After Oral and Inhalative Administration of Racemic Salbutamol or Levosalbutamol

Annika Lisa Jendretzki, Lukas Corbinian Harps, Yanan Sun, Felix Bredendiek, Matthias Bureik, Ulrich Girreser, Xavier De la Torre, Francesco Botrè, Maria Kristina Parr

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: salbutamol; metabolism; excretion rates; salbutamol-4’-O-sulfate; bioanalysis; biosynthesis; SULT1A3

Online: 27 February 2023 (06:27:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1893.v1

Geochemistry and Geochronology (U-Pb and Lu-Hf) of the Soarinho Alkaline Massif (Brazil): Implications on mantle versus crustal signature of syenitic magma

Daniel Adelino Da Silva, Guilherme Loriato Potratz, Mauro Cesar Geraldes

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: syenitic magma sourece; alkali feldpsar syenite; quartz syenite; U-Pb dating; Lu-Hf isotopes

Online: 26 May 2023 (08:34:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1167.v1

Secure IoT communication: Implementing a One-Time-Pad Protocol with True Random Numbers and Secure Multiparty Sums

Julio Fenner, Patricio Galeas, Francisco Escobar, Rail Neira

Subject: Computer Science And Mathematics, Computer Science Keywords: One time pad cryptography; Internet of Things; Secure multiparty computation

Online: 19 March 2024 (16:13:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2258.v1

Numerical Analysis of the Effect of Different Nose Shapes on Train Aerodynamic Performance

Paolo Schito, Luigi Vigevano, Stefano Negri, Kerian Chauvin, Gianluca Colavito, Eric Landolfi

Subject: Engineering, Aerospace Engineering Keywords: High-speed train; Train nose length; Aerodynamic performance; Flow structure; Drag Reduction

Online: 30 July 2024 (09:15:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0450.v1

Performance Assessment of Presurgical Tests in Temporal Lobe Epileptic Patients

Jesús Pastor, Lorena Vega-Zelaya, Rafael G. Sola, Paloma Pulido

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: electroencephalography; Engel’s grade, magnetic resonance imaging; multiple binary logistic model; single photon emission computed tomography; video-electroencephalography.

Online: 7 February 2024 (13:51:24 CET)

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The performance of the presurgical test (preSurg) for temporal lobe epilepsy (TLE) was evaluated via video-electroencephalography (VEEG), electroencephalography (EEG), 99mTc-HmPAO single-photon emission tomography (SPECT) and 1.5 T magnetic resonance imaging (MRI) in a group of 112 men (37.0 ± 1.1 years) and 106 women (39.7 ± 1.1 years) operated on for TLE. The epileptic zone (EZ) was adequately identified to determine whether the patient reached an Engel I grade (EI) at least one year postop. Accuracy was evaluated by the coefficient α, ranging from 3 (when result = EZ) to 2 (result in the same hemisphere as the EZ), 1 (noninformative result) or 0 (EZ in the contralateral hemisphere). The simplicity of diagnosis was defined as the number of preSurg surgeries needed to identify the EZ. EI was obtained in 85.8% of patients even though 42.2% of patients had noninformative MRI results. For preSurg α was (mean ± SEM) = VEEG (2.83 ± 0.04) > MRI (2.14 ± 0.08) > EEG (1.87 ± 0.09) > SPECT (1.71 ± 0.09). The accuracy (combination of sensitivity and specificity) was calculated as follows: VEEG (0.797) > MRI (0.518) > EEG (0.446) > SPECT (0.360). The likelihood positive ratio was greater, and the likelihood negative ratio was lower for VEEG. The most relevant factor for the regression model was VEEG (3.106) > MRI (2.558) > EEG (1.905), and the factors were not significantly related to SPECT. EZs in EI patients with low simplicity were identified mainly by VEEG. A very good postoperative outcome can be obtained even in TLE patients with no lesions on MRI. The VEEG is the most reliable preSurg test and may be the only reliable test for patients with very low simplicity (i.e., difficult).single paragraph of about 200 words maximum. For research articles, abstracts should give a pertinent overview of the work. We strongly encourage authors to use the following style of structured abstracts, but without headings: (1) Background: Place the question addressed in a broad context and highlight the purpose of the study; (2) Methods: briefly describe the main methods or treatments applied; (3) Results: summarize the article’s main findings; (4) Conclusions: indicate the main conclusions or interpretations. The abstract should be an objective representation of the article and it must not contain results that are not presented and substantiated in the main text and should not exaggerate the main conclusions.

Preprint ARTICLE | doi:10.20944/preprints202309.0239.v1

Circular Economy and Solid Waste Management: Connections from a Bibliometric Analysis

Wender Freitas Reis, Cristiane Gomes Barreto, Mauro Guilherme Maidana Capelari

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: circular economy; solid waste management; Language R; bibliometrics

Online: 5 September 2023 (05:12:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0544.v1

Valorization of grain and oil by-products: with special focus on hemicellulose modification

Xiaoxian Liu, Jin Xie, Nicolas Jacquet, Christophe Blecker

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: grain by-products; oil by-products; hemicellulose; arabinoxylan; xylan; modification; industrial application

Online: 10 June 2024 (08:37:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1882.v1

Underreporting of Cases in the COVID-19 Outbreak of Borriana (Spain) During Mass Gathering Events in March 2020: A Cross-Sectional Study.

Salvador Domènech-Montoliy, Maria Rosario Pac-Sa, Diego Sala-Trull, Alba Del Rio-González, Manuel Sanchéz-Urbano, Paloma Satorres-Martinez, Roser Blasco-Gari, Juan Casanova-Suarez, Maria Gil-Fortuño, Laura López-Diago, Cristina Notari-Rodríguez, Oscar Pérez-Olaso, Maria Angeles Romeu-Garcia, Raquel Ruiz-Puig, Isabel Aleixandre-Gorriz, Carmen Domènech-León, Alberto Arnedo-Pena

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; SARS-CoV-2; underreporting; cross-sectional; epidemiological surveillance; factors

Online: 27 June 2024 (05:46:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1221.v1

Towards Zero-Carbon Buildings: Challenges and Opportunities from Reversing the Material Pyramid

Matteo Francesco Ruta, Francesco Pittau, Gabriele Masera

Subject: Engineering, Architecture, Building And Construction Keywords: carbon neutral construction; material diets; biogenic carbon; bio-based materials; sustainable building design

Online: 18 April 2024 (07:51:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0271.v1

D. Paul Sullins

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: induced abortion; depression; suicidality; substance abuse; panel data; fertility surveys; nonresponse bias; National Longitudinal Study of Adolescent to Adult Health (Add Health)

Online: 6 August 2024 (05:18:57 CEST)

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Background and Objectives. To examine trends in the links between induced abortion and subsequent mental health problems for U.S. women approaching completed fertility. Materials and Methods. Panel data on a nationally-representative cohort of 3,842 ever-pregnant women assessed at mean ages of 15, 22, 28 and 37 years from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were examined for pregnancy outcome-related mental health disorders, with extensive adjustment for confounders including sociodemographic dif-ferences, mental health history, and unwanted pregnancies. Outcomes were defined using pub-lished diagnostic criteria or validated index for depression, anxiety disorder, post-traumatic stress disorder (PTSD), and suicide ideation (affective problems); alcohol abuse, drug abuse, opioid abuse, and cannabis abuse (substance abuse problems); and summary counts of affective problems, substance abuse problems and total disorders. Results were adjusted for abortion under-reporting using cross-wave analysis. Results. The relative risk of mental health disorder with exposure to induced abortion followed an inverted “V” pattern as women aged to midlife, increasing from Wave III (age 22; IRR 1.41) to Wave IV (age 28; IRR 1.67), then dropping sharply by Wave V (age 37; IRR 1.20). The population at-tributable fraction of mental health disorder due to abortion dropped from 18.1% at Wave IV to 8.0% at Wave V. Unlike previous Waves, at Wave V mental health risk was more strongly reduced by exposure to childbirth (IRR 0.70, 95% CI .63, .78, p < .001). Reduced relative metrics at Wave V were not due to reduced prevalence of mental health disorders for ever-aborting women, which increased from Wave IV to Wave V by 1.7%, but increased much more, by 20.5%, for never-aborting women. Conclusion. At midlife approaching completed fertility, differential negative psychological out-comes for ever-aborting U.S. women remained elevated but reduced from younger ages.

Preprint ARTICLE | doi:10.20944/preprints202407.1463.v1

Persistent Emotional Distress after Abortion in the United States

D. Paul Sullins

Subject: Public Health And Healthcare, Health Policy And Services Keywords: pregnancy; abortion; emotional distress

Online: 18 July 2024 (11:28:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1997.v1

A Step Forward in Enhancing the Health-Promoting Properties of Whole Tomatoes as a Global Functional Food to Lower the Impact of Non-Communicable Diseases

Pier Giorgio Natali, Mauro Piantelli, Alessandra Sottini, Margherita Eufemi, Cristina Banfi, Luisa Imberti

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: functional food; non-communicable diseases; tomato

Online: 28 August 2024 (10:45:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0119.v1

CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study

Tiziana Ciarambino, filomena pietrantonio, Sara Rotunno, Alessandra Fiorentini, Rosalba Cipriani, Giuseppe Campagna, Giuseppe Straface, Eleonora Pistella, mauro giordano, Francesco Rosiello, Orazio Valerio Giannico, federica lorenzi

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS-CoV-2; COVID-19; gender role; sex differences

Online: 4 August 2021 (15:30:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1711.v1

Conformational Analysis of Trifluoroacetyl Triflate, CF₃C(O)OSO₂CF₃: Experimental Vibrational and DFT Investigation

Agustín Spaltro, Melina G. Peluas, Carlos O. Della Védova, Rosana M. Romano

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: conformations; matrix-FTIR; gas-phase FTIR; Raman; DFT

Online: 26 April 2024 (07:43:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0126.v3

IQGAP1 in Podosomes/Invadosomes Is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

Deborah Rotoli, Natalia Pérez-Rodríguez, Manuel Morales, María Del Carmen Maeso, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: IQGAP1; glioblastoma multiforme (GBM); scaffold protein; podosome/invadosome

Online: 16 January 2017 (10:30:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0481.v1

Development of LA-MRSA Loads in Pigs and Pig Stables during the Fattening Period

Karl Pedersen, Martin Weiss Nielsen, Mette Ely Fertner, Carmen Espinosa Gongora, Poul J. Bækbo

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: LA-MRSA; CC398; pig production; occupational hazard

Online: 6 September 2024 (07:38:18 CEST)

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