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Preprint ARTICLE | doi:10.20944/preprints201902.0093.v1

The Mixed Current Model of Nano-MOSFETs Considering the Effect of Horizontal and Vertical Electric Fields

Heng-Sheng Huang, Ping-Ray Huang, Mu-Chun Wang, Shuang-Yuan Chen, Shea-Jue Wang, Ching-Chuan Chou, LS Huang, Wei-Lun Wang

Subject: Engineering, Electrical And Electronic Engineering Keywords: drift current; diffusion current; mobility; nano-node; model; ALD technology

Online: 11 February 2019 (16:15:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201802.0060.v1

Research on a Precision and Accuracy Estimation Method for Close-range Photogrammetry

Kai-feng Ma, Gui-ping Huang, Hai-jun Xu, Wei-feng Wang

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: surveying; close-range photogrammetry; internal coincidence precision estimation; external coincidence accuracy estimation; experimental work; testing

Online: 7 February 2018 (10:28:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1221.v1

Investigating Fully-Strange Tetraquark System with Positive Parity in a Chiral Quark Model

Yue Tan, Yuheng Wu, Hongxia Huang, Jialun Ping

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: quark model; real scaling method; resonance; Gaussian expansion

Online: 19 October 2023 (10:40:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0170.v1

The Effective Baryon-Baryon Potential with Configuration Mixing in Quark Models

Xinmei Zhu, Hongxia Huang, Jialun Ping

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: baryon-baryon interaction; quark model; configuration mixing

Online: 2 August 2024 (12:20:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0174.v1

Aroma Identification and Classification in 18 Kinds of Teas (Camellia sinensis) by Sensory Evaluation, Hs-Spme-Gc-Ims/Gc×gc-Ms, and Chemometrics

Yanping Lin, Ping Yang, Ying Wang, Yibiao Huang, Huanlu Song

Subject: Biology And Life Sciences, Food Science And Technology Keywords: tea (Camellia sinensis); solid phase micro extraction (SPME); two-dimensional comprehensive gas chromatography-olfactometry-mass spectrometry analysis (GC × GC-O-MS); gas chromatog-raphy-ion mobility spectrometry (GC-IMS); aroma compounds

Online: 2 June 2023 (09:59:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0100.v1

Large-Scale Functional Analysis of CRP-mediated Feed-Forward Loops

Chi-Dung Yang, Hsi-Yuan Huang, Yen-Hua Chen, Sirjana Shrestha, Hsien-Da Huang, Ching-Ping Tseng

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: feed-forward loop (FFL); cAMP receptor protein (CRP); transcriptional factor (TF).

Online: 6 June 2018 (16:00:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0023.v1

Experimental and Numerical Study of Vacuum Resin Infusion for Thin Walled Composite Parts

Sergey Shevtsov, Igor Zhilyaev, Shun-Hsyung Chang, Jyun-Ping Huang, Natalia Snezhina

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polymeric composites; composite technology; vacuum infusion; process modeling and optimization

Online: 3 February 2020 (06:34:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1412.v1

Jump Rope Exercise Improves Executive Function in Children with Attention-Deficit/Hyperactivity Disorder

Liang Li, Zi-Yun Huang, Yi-Juan Lu, Xue-ping Wu

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Attention-deficit/hyperactity disorder; jump rope exercise; children; exercise intervention; executive function

Online: 18 January 2024 (11:34:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0146.v1

Development of UAV Tracking and Coordinate Detection Method Using a Dual-Axis Rotary Platform for an Anti-UAV System

Bor-Horng Sheu, Chih-Cheng Chiu, Wei-Ting Lu, Chu-I Huang, Wen-Ping Chen

Subject: Engineering, Control And Systems Engineering Keywords: unmanned aerial vehicles; dynamic coordinate tracking; computer vision; anti-UAV defense system

Online: 16 June 2019 (10:23:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0601.v1

Successful Aging and Chronic Osteoarthritis

Ray Marks

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: aging; disability; healthy aging; osteoarthritis; pain, rehabilitation, successful aging

Online: 30 July 2018 (22:20:03 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202107.0633.v1

Biofortification - Associated Costs and Finding Alternatives?

Avik Ray

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Biofortification; Agro-biodiversity; HarvestPlus; Hidden Hunger; Orphan Crops; Wild edibles

Online: 28 July 2021 (16:18:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1834.v1

Fractional-Order Load Frequency Control of an Interconnected Power System with Hydrogen Energy-Storage Unit

Ping Wang, Xi Chen, Yunning Zhang, Lei Zhang, Yuehua Huang

Subject: Engineering, Electrical And Electronic Engineering Keywords: Load frequency control; interconnected power system; fractional-order control; improved gradient-based optimizer; parameter tuning

Online: 26 January 2024 (01:58:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0886.v1

The Periodicity of Nuclear Magnetic Moments and Nucleon Binding Energies in Light Nuclides: Implications for Nuclear Structure

Ray Walsh

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: nuclear periodicity; nuclear structure; shell model; nucleon pairing effect; quark structure; representational nuclear chemistry; nucleon binding energy; nuclear magnetic moment

Online: 13 September 2023 (11:13:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0127.v1

Particle Swam Optimization Based Fault Location and Restoration Approach in Microgrids

Wei-Tzer Huang, Kai-Chao Yao, Feng-Ying Wang, Chun-Chiang Ma, Hong-Ting Chen, Ping-Hsuan Hsieh

Subject: Engineering, Energy And Fuel Technology Keywords: fault location; service restoration; particle swam optimization; microgrid; power flow; short-circuit fault

Online: 12 September 2019 (03:59:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1211.v1

A Closer Look at the Perivascular Unit in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus

Melvin Ray Hayden

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Diabetic cerebral microvascular disease; Enlarged perivascular spaces; Glymphatic system; Neurovascular unit; Perisynaptic astrocyte endfeet; Perivascular astrocyte endfeet; Pervascular spaces; Perivascular unit; Postcapillary venule

Online: 15 December 2023 (18:12:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0607.v1

Effects of Limonene on the PAHs mutagenicity risk in Roasted Fish Skin

Yu-Wei Chen, Ping-Hsiu Huang, Yung-Hsiang Tsai, Chii-Ming Jiang, Chih-Yao Hou

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Roasted Fish Skin, PAHs mutagenicity risk, Limonene

Online: 30 September 2018 (10:03:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0538.v1

Developing a High-Temperature Solvent-Free System for Efficient Biosynthesis of Octyl Ferulate

Shang-Ming Huang, Ping-Yu Wu, Jiann-Hwa Chen, Chia-Hung Kuo, Chwen-Jen Shieh

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: ferulic acid esters; octyl ferulate; esterification; Box-Behnken design; response surface methodology; molar conversion; optimum condition

Online: 27 July 2018 (11:43:22 CEST)

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Working Paper ARTICLE

Citrus Fruits Are Rich in Flavonoids for Immunoregulation and Potential Targeting ACE2

Liping Cheng, Weikang Zheng, Ming Li, Jie Huang, Shuzheng Bao, Qiang Xu, Zhaocheng Ma

Subject: Biology And Life Sciences, Food Science And Technology Keywords: citrus flavnoids; naringin; immunoregulation; ACE2; 2019-nCoV

Online: 23 February 2020 (09:49:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0051.v1

Assessment from Multilevel Mixed-Effects Structural Equation Modelling into Urban Resilience

Chich-Ping Hu

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Multilevel Mixed-Effects Structural Equation Modelling; urban resilience; urban service functions; real estate market; social equity

Online: 2 September 2024 (09:02:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0352.v1

Proteins Nsp12 and 13 of SARS-CoV-2 Have Mitochondrial Recognition Signal: A Connection with Cellular Mitochondrial Dysfunction and Disease Manifestation

Upasana Ray, Feroza Begum

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; ARDS; non-structural proteins; mitochondria

Online: 29 June 2020 (10:40:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0170.v1

Evaulation of a Model for Urban Vegetation Barriers’ Effects on Air Pollution

Ray F. Nassar

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Air pollution; environmental hazards; Volatile Organic Compounds

Online: 8 January 2021 (16:59:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.0498.v1

Cerebral Microbleeds Associate with Brain Endothelial Cell Activation-Dysfunction and Blood-Brain Barrier Dysfunction-Disruption with an Increased Risk of Hemorrhagic and Ischemic Stroke That Is Capable of Exacerbating Neurodegeneration

Melvin Ray Hayden

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimers Disease; BBB; Cerebral microbleeds; Dementia; Hypertension; MRI; Neurovascular unit; cerebral small vessel disease; Transmission electron microscopy

Online: 8 May 2024 (12:47:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints201706.0078.v1

On-chip High-finesse Fabry-Perot Microcavities for Optical Sensing and Quantum Information

Mohammad H. Bitarafan, Ray G. DeCorby

Subject: Physical Sciences, Optics And Photonics Keywords: Fabry-Perot microcavities; sensing; cavity QED; microcavity lasers

Online: 16 June 2017 (10:38:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0259.v1

Paying Homage to Microvessel Remodeling and Small Vessel Disease in Neurodegeneration: Implications for the Development of Late-Onset Alzheimer’s Disease

Melvin Ray Hayden

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Brain endothelial cells; Blood-brain barrier; Dementia; Late-onset Alzheimer's disease; Microvessel remodeling; Neurodegeneration; Neurovascular unit; Small vessel disease

Online: 3 September 2024 (16:58:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.2015.v1

Antonio Mazzotti, Laura Langone, Simone Ottavio Zielli, Elena Artioli, Alberto Arceri, Lorenzo Brognara, Francesco Traina, Cesare Faldini

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Subtalar arthrorisis; Pediatric; flatfoot; hallux valgus angle; Intermetatarsal angle

Online: 30 April 2024 (15:02:54 CEST)

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Introduction: Subtalar Arthroereisis (STA) is a surgical intervention for pediatric flexible flatfoot (PFF), primarily targeting hindfoot alignment by limiting excessive subtalar eversion. However, its effects on forefoot parameters remain underexplored. This study aims to investigate radiological changes following STA in pediatric patients. Materials and Methods: A retrospective analysis was conducted on consecutive patients treated with STA for PFF. First ray-related angles, including Hallux Valgus Angle (HVA) and Inter-Metatarsal Angle (IMA), alongside hindfoot radiological parameters such as Meary, Calcaneal Pitch, and Costa Bartani angles, were assessed. Subgroup analysis by gender was performed, and correlations between demographic and pre-operative radiological parameters were examined. Results: Forty-one patients (81 feet) with a mean age of 11.6 years were included, with a mean follow-up duration of 6.4 months. No significant differences were observed in first ray-related an-gles pre- and post-operatively, with mean IMA changing from 7.97° to 7.18° and mean HV angles from 9.51° to 8.66°. Noteworthy improvements were seen in flat foot angles, including Meary, Calcaneal Pitch, and Costa Bartani angles, postoperatively. Age subgroup analysis revealed similar trends in IMA and HVA changes between Group A (operated before peak growth) and Group B (operated later). Higher preoperative angles tended to improve, while lower preoperative IMA and HVA tended to worsen postoperatively, all remaining within normal ranges. Conclusion: STA showed positive radiological outcomes for PFF treatment, while negligible changes in first ray-related angles were observed. Age subgroup analysis indicated similar trends regardless of operation timing. Higher preoperative angles tended to improve, while lower preoperative angles tended to worsen postoperatively, despite all falling within non-pathological ranges. Further re-search is warranted to confirm this correlation.

Preprint ARTICLE | doi:10.20944/preprints202305.2066.v1

All-Optical, Air-Coupled Ultrasonic Detection of Low-pressure Gas Leaks and Observation of Jet Tones in the MHz Range

Kyle G. Scheuer, Ray G. DeCorby

Subject: Physical Sciences, Acoustics Keywords: jet tone; leak detection; air-coupled ultrasound; optical ultrasound detection; optomechanics; buckled dome microcavity

Online: 30 May 2023 (07:30:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0052.v1

Structure of Zn and Na Borophosphate Glasses by X-ray and Neutron Diffraction

Uwe Hoppe, Parker T. Freudenberger, Richard K Brow, Jozef Bednarcik, Alex C. Hannon

Subject: Chemistry And Materials Science, Ceramics And Composites Keywords: borophosphate glasses; short-range order; neutron diffraction; X-ray diffraction

Online: 1 May 2024 (07:15:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0096.v1

Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study

Yalong Dang, Xiao Wang, Yujie Cen, Ying Hong, Ping Huang, Nils Loewen, Chun Zhang

Subject: Medicine And Pharmacology, Ophthalmology Keywords: primary open-angle glaucoma; minimally invasive glaucoma surgery; ab interno trabeculectomy; intraocular pressure; success rate

Online: 11 January 2018 (04:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0344.v1

Low-energy Cosmic Rays and Associated MeV Gamma-ray Emissions in the Protoplanetary System

Xulei Sun, Shuying Zheng, Zhaodong Shi, Bing Liu, Ruizhi Yang

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Protoplanetary disk; Low-energy cosmic rays; Gamma rays; Nuclear de-excitation lines

Online: 4 July 2024 (00:18:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints201608.0021.v1

E-waste Management in South Africa: Case Study: Cathode Ray Tubes Recycling Opportunities

Pontsho Ledwaba, Ndabenhle Sosibo

Subject: Environmental And Earth Sciences, Environmental Science Keywords: electrical and electronic waste; recycling; legislative frameworks; environmental management; landfilling

Online: 3 August 2016 (12:33:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1601.v1

Study on the Measurement of the the Grain Industry Chain Resilience and its Influencing Factors: A Case from China

Song Lin Ma, Ping ping Wang

Subject: Business, Economics And Management, Economics Keywords: grain industry chain resilience; PLS structural equation modeling; spatial variation; geo-detectors

Online: 24 June 2024 (11:32:59 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202003.0419.v9

The ATP Hypothesis Discovers the Missing “Matchmaker” between Proteins and Nucleic Acids

Ping Xie

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ATP hypothesis; origin of genetic code; life’s building block; probiotic “soup”; coevolution; biochemical system; missing “matchmaker”; energy transformation; informatization; structuralization; precellular selection; photo- chemical origin of life; virus; anti-life form; 2019-nCoV

Online: 11 September 2020 (08:39:39 CEST)

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A plenty of theories on the origin of genetic codes have been proposed so far, yet all ignored the energetic driving force, its relation to the biochemical system, and most importantly, the missing “matchmaker” between proteins and nucleic acids. Here, a new hypothesis is proposed, according to which ATP is at the origin of the primordial genetic code by driving the coevolution of the genetic code with the pristine biochemical system. This hypothesis aims to show how the genetic code was produced e.g. by photochemical reactions in a protocell that derived from a lipid vesicle enclosing various life’s building blocks (e.g. nucleotides and peptides). At extant cell, ATP is the only energetic product of photosynthesis, and is at the energetic heart of the biochemical systems. ATP could energetically form and elongate chains of both polynucleotides and polypeptides, thus acting a “matchmaker” between these two bio-polymers and eventually mediating precellular biochemical innovation from energy transformation to informatization. ATP was not the only one that could drive the formation of polynucleotides and polypeptides, but favored by precellular selection. The protocell innovated a photosynthesis system to produce ATP efficiently and regularly with the aids of proteins and RNA/DNA. The completion of permanently recording the genetic information by DNA marked the dawn of cellular life operated by Darwinian evolution. The ATP hypothesis assumes or supports the photochemical origin of life, shedding light on the origins of both photosynthetic and biochemical systems, which remains largely unknown thus far. Based on ATP hypothesis, virus (like the new coronavirus) could not be the earliest life on Earth, as it has neither biochemical systems nor lipid bilayer membrane that provided relatively isolated environment for the development of protobiochemical reactions, although it owns the genetic code of a cellular life. Virus could not be a bridge between life and non-life, but is an anti-life substance, as it depletes cellular material for its own replication, and then spreads by destroying the host cells. It can be imagined that if cellular life are completely wiped out by the virus, the complete destruction of life on Earth would be inevitable.

Preprint ARTICLE | doi:10.20944/preprints202305.1976.v1

XIST-microRNAs/mRNA Network in Circulating CD4⁺ T Cells of the Patients with Hepatocellular Carcinoma

Lien-Hung Huang, Cheng-Shyuan Rau, Yueh-Wei Liu, Chia-Jung Wu, Peng-Chen Chien, Hui-Ping Lin, Yi-Chan Wu, Chun-Ying Huang, Ting-Min Hsieh, Ching-Hua Hsieh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: hepatocellular carcinoma (HCC); CD4+ T cells; next generation sequencing (NGS); long non-coding RNAs (lncRNAs); microRNAs (miRNAs)

Online: 29 May 2023 (05:23:24 CEST)

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Preprint TECHNICAL NOTE | doi:10.3390/sci2020030

On Singular Perturbation of Neutron Point Kinetics in the Dynamic Model of a PWR Nuclear Power Plant

Xiangyi Chen, Asok Ray

Subject: Physical Sciences, Applied Physics Keywords: PWR nuclear power plants; point kinetics; singular perturbation

Online: 26 April 2020 (00:00:00 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1910.v1

Exploring the Spatio-Temporal Evolutionary Characteristics of Paomo Restaurants in Xi’an’s Central Urban Area Through POI Data Analysis

Dawei Yang, Ping Xu, Xiaojuan Yang

Subject: Social Sciences, Geography, Planning And Development Keywords: POI Data, Paomo Restaurants, Spatio-temporal Evolution Characteristics, Xi'an

Online: 29 April 2024 (10:06:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0106.v1

Combined Ketogenic Diet and Walking Exercise Interventions in Community Older Groups

Jia-Ping Wu

Subject: Physical Sciences, Applied Physics Keywords: ketogenic diet; exercise therapy; community health planning; natural; exercise intervention

Online: 6 October 2021 (12:40:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0855.v1

Global Profile of tRNA-Derived Small RNAs in Pathological Cardiac Hypertrophy Plasma and Identification of tRF-21-NB8PLML3E as a New Hypertrophy Suppressor

Jingyi Xu, Buyun Qian, Feng Wang, Ying Huang, Xinxin Yan, Ping Li, Qian Zhang, Yuan Li, Kangyun Sun

Subject: Biology And Life Sciences, Life Sciences Keywords: transfer RNA-derived small RNAs; pathological cardiac hypertrophy; small RNA sequencing; biomarkers

Online: 24 April 2023 (11:01:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1399.v1

Phylogeny Analysis and Functional Characterizatiion of CYP76AHs from Salvia

Zhenyu Zhao, Dongfeng Yang, Juan Guo, Xiuyu Liu, Qishuang Li, Ping Su, Jian Wang, Ying Ma, Luqi Huang

Subject: Biology And Life Sciences, Other Keywords: Salvia; CYP76AH; P450; biosynthesis; functional gene

Online: 19 May 2023 (07:52:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0374.v2

On Soft Lebesgue Measure

Sujay Goldar, Subhasis Ray

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Soft Set, Soft Element, Soft Real Number, Soft Interval, Soft Sequence, Soft Lebesgue Measure.

Online: 8 December 2022 (07:52:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0115.v1

Internet of Things Aware Secure Dew Computing Architecture for Distributed Hotspot Network: A Conceptual Study

Partha Pratim Ray, Karolj Skala

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Dew computing; Internet of Things; Blockchain; Hotspot Network

Online: 5 August 2022 (03:46:27 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202102.0618.v1

The Concept of Training Image-Based Geostatistics for Spatial Distribution of Hydraulic Conductivity

Fiaz Hussain, Ray-Shyan Wu

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Interpolation; Hydraulic Conductivity; Multi-Point Geostatistics; Training Image

Online: 26 February 2021 (12:47:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0221.v1

Solar Wind Charge-Exchange X-ray Emissions from the O⁵⁺ Ions in the Earth’s Magnetosheath

Zhicheng Zhang, Fei He, Xiao-Xin Zhang, Guiyun Liang, Xueyi Wang, Yong Wei

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: solar wind charge-exchange (SWCX); earth magnetosheath; X-Ray spectrum; interplanetary shock; bow shock; Magnetopause

Online: 2 April 2024 (15:13:11 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1325.v2

Deep Learning-based Approach for Optimizing Urban Commercial Space Expansion Using Artificial Neural Networks

Dawei Yang, Jiahui Zhao, Ping Xu

Subject: Business, Economics And Management, Economics Keywords: Commercial space; Points of interest; Deep learning; BP Neural Network

Online: 7 April 2024 (13:58:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1096.v1

Quantifying Quality of Life in a Community Context and Policy Implication—An Application of MIMIC Model

Chich-Ping Hu

Subject: Computer Science And Mathematics, Computer Science Keywords: quality of life; community context; policy implication; MIMIC model; ArcGis

Online: 18 September 2023 (13:48:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1231.v1

Suppression of Ventilation-Induced Diaphragm Fibrosis through the Phosphoinositide 3-Kinase-γ in a Murine Bleomycin-Induced Acute Lung Injury Medel

Li-Fu Li, Chung-Chieh Yu, Chih-Yu Huang, Huang-Pin Wu, Chien-Ming Chu, Ping-Chi Liu, Yung-Yang Liu

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: apoptosis; diaphragm fibrosis; phosphoinositide 3-kinase-g; ventilator-induced diaphragm dysfunction

Online: 18 April 2024 (10:06:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0278.v1

Utilization of Mosque as A Part of Early Warning Systems to Reduce Flood Damage in Samarinda City, Indonesia

Riyan Benny Sukmara, Ray Shyan Wu

Subject: Engineering, Civil Engineering Keywords: flooding, early warning, damage, mosque

Online: 10 March 2021 (13:01:45 CET)

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Samarinda City is one of the most attractive cities in Borneo Island (Indonesia) and also as a capital city of EastBorneo Province. The expansion of urban areas becomes essential due to rapid population and housing demand. Base on the statistical report, the annual population growth rate is 0.018% from the year 2016-2017 with a total population of 843446 inhabitants. Many natural disasters occur in some areas in this city, especially flooding. This natural disaster occurs almost every year, many people suffered and forced to evacuate. In 2018 there is 3 flood event with 28311 people was suffered and evacuated, and 5170 houses were flooded [1]. During the flood event, it was very possible to gain damages to their property and make traffic stuck. One common way to reducing the damages is using Early Warning Systems (EWS). Early warning is a major element for disaster risk reduction, including damages. To prevent and mitigate the impact of a disaster, many countries had taken action to build various methods of a public warning system. An effective early warning system focused on people-centered and comprises the following element, such as risk knowledge, technical monitoring and service, communication and dissemination of warnings, and community response capability [2]. Related to the existing condition which Samarinda is a Muslim-dominated city and obviously has a lot of a number of mosques. This is a good potency to develop an early warning system because every mosque has a loudspeaker for echoing Adzan (Muslim prayer-calling). With this existing condition, the loudspeaker can be utilized as a flood outdoor-voice warning announcer. The aim of this study is to briefly introduce the strategy of dissemination early warning by utilizing mosques. The hope of early warning dissemination is giving enough time to the people to evacuate their property to reduce damages and possibly to giving information to avoiding traffic stuck (in a certain location)due to flooding. The results of this study can be used as input for decision-makers to develop effective flood management strategies and policies, especially in the case of an early warning system where not well-developed in Samarinda.

Preprint ARTICLE | doi:10.20944/preprints202305.2216.v1

Impact of Cooperation and Intra-Specific Competition of Prey on the Stability of Prey-Predator Models with Refuge

Soumyadip Pal, Fahad Al Basir, Santanu Ray

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Mathematical modeling; Bifurcation analysis; Global stability; Direction of Hopf bifurcation; Numerical simulations

Online: 31 May 2023 (10:42:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2009.v1

Characterization of Na_0.5Bi_0.5TiO₃ Single Crystals by X-ray Diffraction, Scanning Electron Microscopy, X-ray Photoelectron Spectroscopy, Optical Absorption, Electric and Thermoelectric Properties Studies

Jan J.Suchanicz, Kamila Kluczewska-Chmielarz, Grzegorz Jagło, Andrzej Kruk, Antoni Kania, Dorota Sitko, Michalina Nowakowska-Malczyk, Marcin Łapiński, Grzegorz Stachowski, Tatiana Kruzina

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Na_0.5Bi_0.5TiO₃ single crystals; insulator-metal transition; electrical conductivities; relaxation process

Online: 30 May 2024 (10:42:39 CEST)

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High-quality and large-size single crystals of lead-free Na0.5Bi0.5TiO3 were grown using the Czo-chralski technique. The crystals had pure perovskite structure with rhombohedral symmetry and were translucent in the visible and near infrared spectral ranges recorded in the interval 350-1050 nm. The energy gaps determined from the X-ray photoelectron spectroscopy (XPS) and optical measurements were approximately 2.92 eV. The current-voltage characteristics, depolarization current, dc (σdc) and ac (σac) electrical conductivity, and Seebeck coefficient of the crystals were investigated. The frequency/temperature-dependent electrical properties were also measured and analyzed through complex impedance spectroscopy. An overlapping reversible insulator-metal transition (resistive switching) on nanoscales, caused by the electric field, was detected. This was the first time that most of these investigations were performed for this material. The following conductivity mechanisms of NBT single crystals were identified: (i) quasi-free electron and hole conduction and hopping-charges mechanism at low temperatures, (ii) small polaron conductivity in the middle temperature range, and (iii) a significant contribution of the oxygen vacancies to conductivity in the high temperature range. The activation energy values determined from the conductivity data, the imaginary part of the electric impedance and the modulus indicate that the relaxation process in the high-temperature range is attributable to both single and double ionized oxygen vacancies, in combination with the hopping of electrons between Ti4+ and Ti3+. P-type electrical conductivity was also found. These discoveries create new possibilities of reducing the electrical conductivity of NBT and improving the process of effectively poling this material. The density of the electronic states was investigated using an ab initio method. The energy gap cal-culated for NBT (R3c) was 2.8 eV, and is well comparable to those determined from XPS and optical measurements. Our results indicate the possibility of tuning material properties by inten-tionally creating non-stoichiometry/structural defects (oxygen vacancies, cation excess and cation deficiency).

Preprint ARTICLE | doi:10.20944/preprints201703.0016.v1

A 14-bit Hybrid Incremental Sigma-Delta/Cyclic ADC for X-ray Linear Array Sensor

Yuze Niu, Yacong Zhang, Zhuo Zhang, Miaomiao Fan, Wengao Lu, Zhongjian Chen

Subject: Engineering, Electrical And Electronic Engineering Keywords: hybrid ADC; sigma-delta ADC; cyclic ADC; pseudo-differential OTA; X-ray sensor

Online: 2 March 2017 (08:37:48 CET)

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Working Paper ARTICLE

Lung Damage Mechanisms For COVID-19 and Other Lung Infections, and Driving Force in Leukecyte Recruitment and Migration

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: SARS-CoV-2 COVID-19; lung damage mechanisms; leukecyte recruitment; viral infection; immune response; temperature and humidity; interstitial pressure change

Online: 9 September 2020 (11:32:55 CEST)

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To understand lung damage caused by COVID-19, we deduced two-phase lung damage mechanisms. After the lungs are infected with SARS-CoV-2 virus, the affected lung tissue swells and surface properties of pulmonary capillaries change, resulting in an increased flow resistance of affected capillaries. If a sufficient number of capillaries are affected by the infection, the swelling and increased cell wall adhesion collectively raise pulmonary vascular resistance. The increased vascular resistance further increases the dwell times of WBCs in affected capillaries and nearly capillaries. When pulmonary pressure is sufficiently higher, WBCs are forced to squeeze into interstitial spaces or alveolar spaces when local pressures are higher than what the capillaries can withstand. When more and more WBCs are dynamically retained, the flow resistance of more capillaries rises, pulmonary vascular resistance rises, and pulmonary pressure rises. The rise in the pulmonary pressure in turn results in elevated capillary pressures. When capillary pressures around the alveoli are sufficiently high, they cause interstitial pressures to change from normally negative values to positive values. The positive pressures cause fluid leakage to the alveolar space and thus degrade lung function. Tissue swelling, and occupation of WBCs in interstitial spaces and alveolar spaces further reduce compressible volume, and thus cause further rise in the pulmonary vascular resistance and pulmonary pressure. When the pulmonary pressure has reached a critical point as in the second phase, the blood breaks capillary walls and squeezes through interstitial spaces to reach alveolar spaces, resulting in irreversible lung damages. The available free volume in the thorax cage, organ usable capacities, temperature and humid are expected to have great impacts on degree of lung damages. The free volume in the thorax cage, lung usable surplus capacity, and other organ usable capacities determine the arrival time of last-phase irreversible damage. The mechanisms imply that the top priority for protecting lungs is maintaining pulmonary micro-circulation and preserving organ functions in the entire disease course while controlling viral reproduction should be stressed in the earliest time possible. The mechanisms also explain leukecytes are recruited and migrated into inflamed tissues by increasing their dwell times caused by increased local flow resistance.

Preprint ARTICLE | doi:10.20944/preprints202304.0477.v1

Transplanting Heterologous Mitochondria from Human Umbilical Vein Endothelial Cells Reduces the Malignancy of Melanoma Cells

Fu-Chen Kuo, Bi-Ling Cheng, Ching-Chung Tsai, Ping-Chen Chen, Hsin-Yi Tsai, Kuen-Jang Tsai, Yaw-Bin Huang, Chung-Jung Liu, Deng-Chyang Wu, Ming-Wei Lin, Bin Huang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Mitochondrial transplantation; Mitophagy; HUVEC; melanoma; EMT; malignancy

Online: 18 April 2023 (04:10:03 CEST)

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Working Paper ARTICLE

Surgery, Chemotherapy and Radiotherapy Promote Cancer Growth Speeds and Shorten Patient Lives

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; surgery; chemotherapy; radiotherapy; health optimization; exercises; diet; emotion; chronic stress; kinetics; lethal factors

Online: 24 November 2019 (04:40:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0862.v1

Enabling Low-Dose In Vivo Benchtop X-ray Fluorescence Computed Tomography through Deep Learning-Based Denoising

Naghmeh Mahmoodian, Mohammad Rezapourian, Asim Abdulsamad Inamdar, Kunal Kumar, Melanie Fachet, Christoph Hoeschen

Subject: Engineering, Bioengineering Keywords: Deep learning; Artificial Intelligence; Xray Fluorescence; XFCT; AI; DL

Online: 14 March 2024 (12:26:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0667.v1

Using Muscle Element Fingerprint Analysis (EFA) to Trace and Determine the Source of Hypophthalmichthys nobilis in the Yangtze River Basin

Chao Song, Chengyao Yang, Feng Zhao, Jilin Xie, Hong Tao, Xiaorong Huang, Ping Zhuang

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Hypophthalmichthys nobilis; element fingerprint analysis (EFA); Yangtze River basin; lake; traceability

Online: 9 July 2024 (07:12:26 CEST)

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Hypophthalmichthys nobilis are widely distributed in the Yangtze River basin and its related lakes. They are an important economic fish species and are a famous cultured species known as the "Four Famous Domestic Fishes" in China. Currently, with the fishing ban in the Yangtze River basin, fishing for H. nobilis in natural water bodies of the Yangtze River basin has been completely prohibited. In order to identify the sources of H. nobilis appearing in the market, further control and accountability, it is necessary to trace the sources of H. nobilis in the Yangtze River basin and its related water bodies. Therefore, this study identified and traced different sources of H. nobilis through muscle element fingerprint analysis (EFA). The results show that H. nobilis from different stations have characteristic element compositions. The characteristic element of H. nobilis from Wuhan (WH) is Pb, which is significantly higher than that in other stations; the characteristic element from Anqing (AQ) is Hg, which is significantly higher than that in other stations; and the characteristic element from Taihu (TH) is Al, which is significantly higher than that in other water areas. Multivariate analysis selected different spatial distribution patterns of 4 discriminant elements ratios (Pb/Ca, Cr/Ca, Na/Ca, Al/Ca) in the muscle of H. nobilis in the Yangtze River basin and its related lakes. The study suggests that the screened discriminative elements can be used to visually distinguish different sources of H. nobilis, and to quickly trace and verify the origin of newly emerging samples. Therefore, the use of selected discriminant element fingerprint features to trace the origin of new samples has been proven to be feasible. By further discriminating and verifying the muscle element fingerprints of new samples, the discrimination rate is high. Therefore, Multivariate analysis for muscle element fingerprint can be used for origin traceability of samples of unknown origin in market supervision.

Preprint ARTICLE | doi:10.20944/preprints202408.2124.v1

Effectively Increase the L(+)-Isomer Proportion of Ethyl Lactate in Baijiu by Isolating and Applying L(+)-Lactic Acid-Producing Bacteria

Zhiqiang Ren, Lvchang Liu, Tuoxian Tang, Keyi Huang, Zhiguo Huang

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Strong-aroma Baijiu; L(+)-lactic acid; L(+)-ethyl lactate; Fermented grains; Bacillus licheniformis; Bacillus cereus

Online: 29 August 2024 (08:36:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0433.v1

Astrosat SXT X-ray Spectrum Changes over the 35-Day Cycle in Hercules X-1

Denis Leahy, Riddhiman Sharma

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: binaries; eclipsing — star; neutron— stars; individual (HZ Her/ Her X-1)

Online: 7 June 2024 (08:00:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0525.v1

Recent Advances for the Synthesis of Dihydroquinolin-2(1H) ‑ones via Catalytic Annulation of α,β-unsaturated N-arylamides

Yan-Ning Niu, Lin-shuang Tian, Huai-Zhong Lv, And Ping-Gui Li

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: 3,4-dihydroquinolin-2(1H)-one; α,β-unsaturated N-arylamides; radical; photochemical; annulation

Online: 7 June 2023 (10:12:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1511.v1

A preliminary study on the occupational performances in immersive virtual and real environments in stroke patients

Xijun Wei, Yixi Wei, Dashuang Wu, Ping Zhou, Ping Qin, Yingying Zhang, Jing Zhu, Zhanbing Ren, Hai Li, Yumei Zhang

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Instrumental activities of daily living; immersive virtual reality; Occupational performance

Online: 22 September 2023 (09:56:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0057.v1

Hijacking the Host Immune Cells by Dengue Virus: Molecular Interplay of Receptors and Dengue Virus Envelope

Feroza Begum, Sandeepan Das, Debica Mukherjee, Upasana Ray

Subject: Biology And Life Sciences, Virology Keywords: DENV; tropism; receptors; entry; immune cells

Online: 5 August 2019 (08:14:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0847.v1

MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic Potential

Junjiang Fu, Saber Imani, Mei-Yi Wu, Ray-Chang Wu

Subject: Biology And Life Sciences, Life Sciences Keywords: microRNA; miR‐34; tumor suppressor; miRNA therapy

Online: 10 August 2023 (10:53:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0052.v1

A Study of McVittie Spacetime in Stationary and Dynamical Regime

Indranath Bhattacharyya, Saibal Ray, Riju Nag, Samudra Sundar Nag

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Einstein equations; McVittie solution; black hole; dark energy; embedded spacetime

Online: 6 June 2022 (03:17:36 CEST)

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Working Paper ARTICLE

Treatment Strategies for Reducing Damages to Lungs in Coronavirus and Other Lung Infections

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: coronavirus COVID-19; SARS; MERS; viral reproduction; immune response; lung infection influenza; deep breathing; diet; emotional stress; lifestyle

Online: 23 March 2020 (06:34:44 CET)

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Working Paper ARTICLE

Preventive, Mitigating and Treatment Strategies for Containing or Ending the COVID-19 Pandemic

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: coronavirus; COVID-19; viral reproduction; immune response; low temperature injury; lung damages; cold flu influenza; deep breathing exercises; diet; emotion stress; lifestyle

Online: 4 March 2020 (05:30:58 CET)

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To understand great disparities in disease outcomes between CIVID-19 patients, we explore infection and host responses in kinetics. From existing data, we deduced a model that the lungs are damaged by rapidly rising flow resistance as a result of retaining white blood cells in lung tissues. The retention of white blood cells is initially triggered by viral infection but aggravated by injuries caused by low temperature. Lungs are initially damaged by fluid leakage, rapidly followed by extruding blood into alveolar spaces. The step of blood extruding is predicted to take place in a very short time. Our simulations show that as little as 0.1% retention of white blood cells in the lungs can lead to their failure in 5 to 10 days. The small degrees of imbalance implies that this imbalance could be corrected by a large number of factors that are known to reduce flow resistance. The model implies that the top priority is maintaining blood micro-circulation and preserving organ functions in the entire disease course, especially after the virus has spread the whole lungs. From exploring a large number of hypothetical infection modes, we propose preventive, mitigating and treatment strategies for ultimately ending the pandemic. The first strategy is avoiding exposures that could result in widespread damages to lungs and taking post exposure mitigating measures that would reduce disease severity. The second strategy is reducing death rate and disability rate from the current levels to one tenth for infected patients by using multiple factors health optimization method. The double reduction strategies are expected to generate a series of chain reactions that favor mitigating or ending the pandemic. Some reactions include a big reduction of the amount of viral discharges from infected patients into the air, the avoidance of panic, chronic stress and emotional distress, and cross-infections which are expected in quarantines. The double reductions would have a final effect of ending the pandemic.

Preprint ARTICLE | doi:10.20944/preprints202408.2064.v1

Study on the Spatial Layout Patterns of Townhouses: A Case Study of Kaohsiung City

Cheng Chi Tseng, Long sheng Huang, Chung Fah Huang

Subject: Engineering, Architecture, Building And Construction Keywords: Townhouses; Principal Spaces; Spatial Layout; Relevance

Online: 29 August 2024 (16:48:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0572.v1

Clinical Trials and Reductionist Approach Preclude Cures for Chronic Diseases Due to Flawed Presumptions

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Other Keywords: randomized controlled clinical trials; mathematical model; binary system; statistical analysis; epidemiological model; junk science; reductionist treatments; failure of medicine

Online: 24 September 2020 (08:13:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0587.v1

Women of Color in the Health Professions: A Scoping Review of the Literature

Olihe Okoro, Omolayo Umaru, Meghana Ray

Subject: Social Sciences, Gender And Sexuality Studies Keywords: Intersectionality; Healthcare professions; Women of color; Pharmacy; Racial/Ethnic inequity; Gender inequity; Discrimination; Professional advancement; Underrepresentation

Online: 9 November 2023 (07:29:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0351.v1

BCG Vaccination Strategy for Preventaion against COVID-19: Hype or Hope?

Keshav Rajarshi, Aroni Chatterjee, Shashikant Ray

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; BCG immunization; SARS-CoV-2; immunity and tuberculosis

Online: 19 April 2020 (13:55:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0246.v1

Association of COVID-19 Disease Severity with Transmission Routes and Suggested Changes to Community Guidelines

Jianqing Wu, Zha Ping

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: coronavirus; COVID-19; disease severity; transmission route; infection route; lung damages; cold flu influenza

Online: 15 March 2020 (14:39:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0061.v1

Coastal Upwelling in the Bay of Bengal: Role of Local and Remote Windstress

Sthitapragya Ray, Debadatta Swain, M. M. Ali, Mark A. Bourassa

Subject: Environmental And Earth Sciences, Oceanography Keywords: Coastal upwelling; Upwelling index; Scatterometer; Wind stress; Kelvin Wave; Ekman Transport

Online: 5 July 2022 (05:36:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0059.v1

Optimization of Lactoperoxidase and Lactoferrin Separation on an Ion-Exchange Chromatography Step

Naeimeh Faraji, Yan Zhang, Ajay K. Ray

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cation exchange chromatography; minor milk protein; response surface modeling; simulation; steric mass action (SMA); optimization

Online: 12 January 2017 (09:59:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0147.v1

A Comparative Analysis of the Proteins and Lipids in Breast, Leg, and Thigh Meats of a Commercial Domesticated Turkey

W. Keith Ray, Sherry B. Hildreth, Judith M. Jervis, Richard F. Helm

Subject: Biology And Life Sciences, Food Science And Technology Keywords: glycolysis; lipidome; meat; mitochondria; oxidation; proteome; turkey

Online: 23 November 2017 (03:11:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0038.v1

Coastal Upwelling in the western Bay of Bengal: Role of Local and Remote Windstress

Sthitapragya Ray, Debadatta Swain, M. M. Ali, Mark A. Bourassa

Subject: Environmental And Earth Sciences, Oceanography Keywords: Coastal upwelling; Upwelling index; Scatterometer; Wind stress; Kelvin Wave; Ekman Transport

Online: 2 September 2022 (09:57:06 CEST)

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Working Paper ARTICLE

Randomized Clinical Trial Is Biased and Invalid In Studying Chronic Diseases, Compared with Multiple Factors Optimization Trial

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: clinical trial; statistical analysis; experimental error; chronic diseases; cancer; health optimization; hypothesis test; variance analysis; covariance; stratification; randomization

Online: 21 November 2019 (04:04:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0281.v2

Mutation Hot Spots in Spike Protein of SARS-CoV-2 Virus

Feroza Begum, Arup Kumar Banerjee, Upasana Ray

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; S protein; RBD; S1; S2

Online: 7 September 2020 (04:15:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0068.v1

Researcher Conduct Determines Data Reliability

Mark N. Wass, Larry Ray, Martin Michaelis

Subject: Social Sciences, Behavior Sciences Keywords: reproducibility crisis; replication crisis; data reliability; bias; publication bias; meta-research

Online: 5 April 2018 (10:54:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1501.v1

X-ray Microtomography Analysis of Integrated Crop-Livestock Production Impact on Soil Pore Architecture

José V. Gaspareto, Luiz Fernando Pires

Subject: Environmental And Earth Sciences, Soil Science Keywords: Computed tomography; Image analysis; Minimum tillage; No-tillage; Soil structure; Soil management; Soil porous structure

Online: 23 May 2024 (07:35:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0064.v1

Identification of Secondary Phases in Cu₂ZnSnS₄ Layers by In-depth Resolved X-ray Photoelectron Spectroscopy Analysis

Xianfeng Zhang, M. Kobayashi

Subject: Chemistry And Materials Science, Other Keywords: secondary phases; CZTS film; XPS

Online: 12 January 2017 (11:04:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1333.v1

Effects of a Bank Plant on the Control of Rice Planthoppers: A Field Study

Xin Guo, Qiao-yu Zhou, Meng-meng Ru, Bei Cao, Xin Huang, Xu-song Zheng, Ping-yang Zhu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Leersia sayanuka; bank plant; sesame; rice; ecological engineering for pest control

Online: 21 May 2024 (04:48:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0136.v1

Nonsingular phantom cosmology in Five Dimensional f(R,T) Gravity

Rakesh Ranjan Sahoo, Kamal Lochan Mahanta, Saibal Ray

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Phantom energy; LRS Bianchi type-I; $f(R,T)$ theory; $5d$ spacetimes

Online: 8 August 2022 (08:11:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0524.v1

Flood Management in Samarinda, Indonesia: Recent Progress

Riyan Benny Sukmara, Ray Shyan Wu, Ariyaningsih Ariyaningsih

Subject: Engineering, Automotive Engineering Keywords: urban flooding; flood management; flood disaster; Samarinda;

Online: 23 February 2021 (15:46:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0153.v1

Cosmic-Ray Extremely Distributed Observatory: Status and Perspectives

Dariusz Gora

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: Cosmic-rays; Citizien Science; Extensive air showers

Online: 8 October 2018 (15:45:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0274.v1

Chrysoeriol Improves Embryo Development by Reducing Oxidative Stress and Autophagy in Vitro Porcine

Chao-Rui Wang, He-Wei Ji, Sheng-Yan He, Rong-Ping Liu, Xin-Qin Wang, Jing Wang, Chu-Man Huang, Yong-Nan Xu, Ying-Hua Li, Namhyung Kim

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: chrysoeriol; embryo development; porcine; oxidative stress; autophagy

Online: 16 January 2023 (07:54:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0195.v1

Digital Miniature Cathode Ray Magnetometer

Marcos Turqueti, Gustav Wagner, Azriel Goldschmidt, Rebecca Carney

Subject: Engineering, Electrical And Electronic Engineering Keywords: Magnetometer; Magnetic Probe; Imager; Cathode Ray; Undulator; DSP; CMOS sensor; Cryo-genic; Cold Electronics; Magnetoencephalography

Online: 4 January 2024 (03:38:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0227.v1

On the Ray-Wavefront Duality

Antonio Diaz-Cano, Francisco Gonzalez-Gascon, Luis Sanchez-Soto

Subject: Physical Sciences, Optics And Photonics Keywords: geometrical optics; ray equation; eikonal equation; wavefronts

Online: 18 February 2022 (09:02:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0298.v2

Cosmic Ray Extremely Distributed Observatory

Piotr Homola, Dmitriy Beznosko, Gopal Bhatta, Łukasz Bibrzycki, Łukasz Bratek, Michalina Borczyńska, Nikolay M. Budnev, Dariusz Burakowski, David Edwin Alvarez-Castillo, Kevin Almeida Cheminant, Aleksander Ćwikła, Punsiri Dam-o, Niraj Dhital, Alan Duffy, Piotr Głownia, Krzysztof Gorzkiewicz, Dariusz Góra, Alok C. Gupta, Zuzana Hlávková, Martin Homola, Joanna Jałocha, Robert Kamiński, Michał Karbowiak, Marcin Kasztelan, Renata Kierepko, Marek Knap, Péter Kovács, Szymon Kuliński, Bartosz Łozowski, Marek Magryś, Mikhail V. Medvedev, Justyna Mędrala, Jerzy W. Mietelski, Justyna Miszczyk, Alona Mozgova, Antonio Napolitano, Vahab Nazari, Y. Jack Ng, Michał Niedźwiecki, Cristina Oancea, Bogusław Ogan, Gabriela Opiła, Krzysztof Oziomek, Maciej Pawlik, Marcin Piekarczyk, Bożena Poncyljusz, Jerzy Pryga, Matías Rosas, Krzysztof Rzecki, Jilberto Zamora-Saa, Katarzyna Smelcerz, Karel Smolek, Weronika Stanek, Jarosław Stasielak, Slawomir Stuglik, Jolanta Sulma, Oleksandr Sushchov, Manana Svanidze, Kyle Tam, Arman Tursunov, José-M. Vaquero, Tadeusz Wibig, Krzysztof W. Woźniak

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: cosmic rays; cosmic ray ensembles; extensive air showers; large scale cosmic ray correlations; CREDO Collaboration

Online: 15 October 2020 (16:13:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1104.v1

Elucidating the Role of Immune Cell Dysregulation in Atypical Hemolytic Uremic Syndrome: A Comprehensive Single-Cell Sequencing Analysis

I-Ru Chen, Chiu-Ching Huang, Siang‑Jyun Tu, Guei-Jane Wang, Ping-Chin Lai, Ya-Ting Lee, Ju-Chen Yen, Ya-Sian Chang, Jan‑Gowth Chang

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: hemolytic uremic syndrome; complement; single cell sequencing

Online: 16 May 2023 (05:36:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0089.v1

Scale-Dependent Light Scattering Analysis of Textured Structures on LED Light Extraction Enhancement Using Hybrid Full-Wave Finite-Difference Time-Domain and Ray-Tracing Methods

Tsung-Xian Lee, Ching-Chia Chou

Subject: Physical Sciences, Optics And Photonics Keywords: Light-emitting diodes; Light extraction efficiency; Textured structures; Light scattering; BSDF, BRDF, and BTDF

Online: 15 March 2017 (00:12:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0030.v1

Microstructure and Mechanical Properties of the Ni/Ti/Nb Multilayer Composite Manufactured by Accumulative Pack-roll Bonding

Nan Ye, Xue-ping Ren

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Ni/Ti/Nb multilayer composite; accumulative roll bonding; microstructure; mechanical properties

Online: 3 February 2020 (11:00:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1344.v1

Chinese Cultural Values and Happiness: the Composition and Expanse of Happiness Circle

Xu Erjia, Liao Sihua, Hu Ping

Subject: Social Sciences, Psychology Keywords: Happiness; Chinese Cultural Values; Happiness Circle; Psychological Traditionality; Psychological Modernity

Online: 18 December 2023 (13:05:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0495.v1

Ruxolitinib Combined with Gemcitabine against Cholangiocarcinoma Growth via the jak2/stat1/3/aldh1a3 Pathway

Shin-Yi Chung, Yi-Ping Hung, Yi-Ru Pan, Yu-Chan Chang, Chiao-En Wu, Dennis Shin-Shian Hsu, Peter Mu-Hsin Chang, Meng-Lun Lu, Chi-Ying F. Huang, Yeu Su, Michael Hsiao, Chun-Nan Yeh, Ming-Huang Chen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cholangiocarcinoma; ALDH1A3; Ruxolitinib

Online: 21 June 2021 (09:37:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0033.v1

The Influence Dose of Nicotine Exposure on H520 Smoking-related Non-Small-Cell Lung Carcinoma Cell Growth and Toxicity

Jia-Ping Wu, Ching-Yi Peng

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Nicotine; carcinogenesis; growth; toxicity; Carcinoma; Non-Small-Cell Lung

Online: 4 June 2020 (12:14:49 CEST)

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Nicotine exposure may affect NSCLC is associated with lung cancer in humans. Whether nicotine exhibits carcinogenesis promoted activities in tumor growth still unknown. Nicotine is known to have dichotomous effects on cancer biology, acting like a pro- or anti-carcinogenesis agent. There are different functions between adenocarcinoma and squamous NSCLC cancer cells. Excess generation of nicotine may inhibit mitochondrial metabolism, protein modification, and DNA cleavage. Materials and Methods: We used the H520 NSCLC line obtained from human lung epithelial cells to detected nicotine growth and toxicity using MTT assay and western blotting. The concentration of nicotine stimulated cell growth to correspond to low concentration, while high concentration was cytotoxic. Results: According to MTT assay results, at 1.0 μM nicotine has significantly enhanced the H520 cell viability (%). Nicotine induced lung cancer carcinogenesis through mechanisms of α7nAchR, EGFR, HDAC2/4/5, Cyclin D/Cyclin E, Bcl-2, p-Akt, and inflammatory proteins of NF-KappaB and COX2 increases at 1.0 μM. Apoptosis proteins were decreases at 1.0 μM nicotine by p21, p27, c-jun, and p38α using western blotting. Nicotine stimulates tumor growth is mediated through α7nicotinic-acetylcholine receptors (α7nAChR), possibly involving inflammation. On the other hand, at high nicotine concentrations (> 1.0 μM) with consistent cytotoxic effects and appeared to be due to direct cell kill. Nicotine can prevent apoptosis induced by NSCLC. Conclusion: Therefore, the effects on chemotherapeutics by NSCLC malignant cell lines, nicotine in concentrations as low as 1.0 μM decreased. These mechanisms are responsible for the genotoxic effects caused by nicotine. This leads to downstream effects on decreased apoptosis, increased cell proliferation and transformation. The malignant NSCLC cells respond to the treatment with nicotine in lung cancer, the nicotine-mediated induction of growth may provide one of its links to α7nAchR or EGFR.

Preprint ARTICLE | doi:10.20944/preprints202312.0113.v1

Vehicle PEPS System with Intelligent Internet of Things

Ray-I Chang, Tzu-Chieh Lin, Jeng-Wei Lin

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Passive Entry Passive Start; Smart Watch; Electrocardiogram; Long Short-Term Memory; Auto Encoder; Collective Decision

Online: 4 December 2023 (04:26:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1693.v1

Promotion Effect of H2S with High Concentrations on Catalytic Dry Reforming of Methane in Sour Natural Gas

Hengchang Ni, Xiaoyu Jia, Li Yu, Yuyang Li, Ping Li

Subject: Engineering, Energy And Fuel Technology Keywords: Sour natural gas; Dry reforming of methane; High H2S concentration; Promotion effect; MgO-based catalyst; S-adsorbed species

Online: 25 April 2024 (16:03:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0313.v3

Small-Object Detection in Remote Sensing Images with End-to-End Edge-Enhanced GAN and Object Detector Network

Jakaria Rabbi, Nilanjan Ray, Matthias Schubert, Subir Chowdhury, Dennis Chao

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: object detection; faster region-based convolutional neural network (FRCNN); single-shot multibox detector (SSD); super-resolution; remote sensing imagery; edge enhancement; satellites

Online: 29 April 2020 (13:33:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1623.v2

Methodologies Toward Optimization of Y₂O₃:Eu@SiO₂ Nanoparticles as Photosensitizers for X-Ray Activated Photodynamic Therapy (XPDT) of Cancer

Hannah J. Zhang, Tristan Ide, Maharajan Sivasubramanian, Lara Leoni, Jeffrey S. Souris, Divya Brahmbhatt, Eve Tanios, Ariel Pan, Shih-Hsun Cheng, Nai-Tzu Chen, Leu-Wei Lo, Chin-Tu Chen

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Cancer; Y₂O₃:Eu@SiO₂Nanoparticles; Photodynamic Therapy; Photosensitizer ; ;

Online: 23 July 2024 (09:47:03 CEST)

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Traditional photodynamic therapy (PDT) is often limited in its efficacy by insufficient light penetration, inefficient photosensitizer energy transfer, and inadequate target tissue oxygenation. X-ray activated PDT (XPDT), using nanoparticle (NPs) photosensitizers comprised of europium-doped yttrium oxide cores encased within silica shells (Y₂O₃:Eu@SiO₂), offers the potential of overcoming most of these limitations. Aimed at maximizing the generation of reactive oxygen species (ROS), this study reports methodologies for investigation of the effects of synthesis conditions on the characteristics of Y₂O₃:Eu@SiO₂NP. Transmission electronic microscope (TEM) revealed that the NP core diameter was linearly, positively correlated with condensation time (R2 = 0.7357, p < 0.05) and linearly, negatively correlated with urea concentration (R2 = 0.958, p < 0.05). The addition of cetyltrimethylammonium bromide (CTAB) during core synthesis demonstrated enhanced particle dispersion. Silica coating via APTES-1 and TEOS-3 conditions resulted in Y₂O₃:Eu@SiO₂ NPs that generated the highest ROS, with 8.7-fold and 8.9-fold increase respectively in relative fluorescence intensity at 8 Gy irradiation compared to a 5.2-fold increase in PBS under the same condition. In vivo evaluation using 18F-fluorothymidine positron emission tomography (18F-FLT PET) of mouse xenografts of a human prototypical cancer (ovarian) revealed a 55% reduction in tumor proliferation of radiation-sensitive CAOV3 tumors treated with Y₂O₃:Eu@SiO₂ NPs compared to a 19% reduction in tumor proliferation of radiation-resistant SKOV3 tumors on the fourth day post-treatment. Taken together, these findings suggest Y₂O₃:Eu@SiO₂ NPs can serve as effective photosensitizers for XPDT and their performance characteristics can be optimized by selecting synthesis conditions and parameters to deliver the desirable therapeutic effects, offering novel approaches to circumventing many of the limitations of conventional PDT in the treatment of cancer.

Preprint ARTICLE | doi:10.20944/preprints202405.1510.v1

Synthesis, Characterization, X-ray Molecular Structure, Antioxidant, Antifungal and Allelopathic Activity of a new Isonicotinate-derived meso-Tetraarylporphyrin

Nour Elhouda Dardouri, Soukhayna Hrichi, Pol Torres, Raja Chaâbane-Banaoues, Alessandro Sorrenti, Thierry Roisnel, Ilona Turowska-Tyrk, Hamouda Baba, Joaquim Crusats, Albert Moyano, Habib Nasri

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: free base porphyrin; isonicotinic acid; X-ray molecular structure; UV-visible; fluorescence; antioxidant activity; antifungal activity; allelopathic activity

Online: 23 May 2024 (12:30:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0232.v1

Characterization of Qu-aroma of Medium-High Temperature Daqu from Different Production Areas Using Sensory Evaluation, E-nose, and GC-MS/O Analysis

Jie Deng, Jia Zheng, Xing Li, Zhiguo Huang, Dan Huang, Guangbin Ye, Huibo Luo

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Medium-High Temperature Daqu; Qu-aroma; Volatile compounds

Online: 4 September 2024 (03:08:27 CEST)

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BACKGROUND: Qu-aroma is a critical quality indicator for medium-high temperature Daqu (MT-Daqu), significantly influencing the aroma profile of strong-aroma Baijiu (SAB). SAB is produced across various regions in China, each with unique environmental conditions and production techniques. These regional differences are likely to cause variations in the Qu-aroma of MT-Daqu. Despite this, comprehensive research on the variations in Qu-aroma across different regions has been lacking. This study aims to address this gap by utilizing Gas Chromatography-Olfactometry-Mass Spectrometry (GC-O-MS) and electronic nose (E-nose) technology, combined with sensory evaluation, to analyze the differences in Qu-aroma characteristics and volatile compound profiles of MT-Daqu from seven distinct production areas.RESULTS: Sensory analysis identified seven broad aroma categories and 25 specific aromas characterizing the Qu-aroma of MT-Daqu samples. Chen aroma and roasted aroma were notably more prevalent in MT-Daqu samples from Sichuan compared to those from other regions (P < 0.05), while the fermentation aroma was less prominent in Sichuan samples. In total, 123 volatile compounds were detected in MT-Daqu, with 46 classified as aroma-active compounds. Among these, 21 aroma-active compounds were identified as markers distinguishing Sichuan MT-Daqu from those produced in non-Sichuan regions, showing significant differences in their concentrations (P < 0.05). Additionally, six major aroma-active compounds-ethyl isovalerate, ethyl heptanoate, hexanal, 1-nonanal, (E)-2,4-decadienal, and 2,3-dimethyl-5-ethylpyrazine-were found to significantly contribute to the aroma differences between Sichuan and non-Sichuan MT-Daqu.CONCLUSION: This study delineates the distinct Qu-aroma characteristics of MT-Daqu from various SAB production areas and identifies the aroma-active compounds responsible for these differences. The insights gained from this research offer valuable guidance for optimizing flavor profiles in MT-Daqu production, potentially enhancing the overall quality and regional distinctiveness of the product.

Preprint REVIEW | doi:10.20944/preprints202306.2011.v1

Gamma Ray Pulsars and Opportunities for the MACE Telescope

Atul Pathania, K. K. Singh, Kuldeep Kumar Yadav

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Pulsars; gamma-rays; MACE Telescope

Online: 29 June 2023 (07:23:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0083.v1

Communicating about Sex Is Important in Generating Positive Perceptions about One’s Sexual and Romantic Life. The Last Decade Has Provided Insight into the Theoretical Applications on Sex Communication Research. While the Focus on Extant Research Focuses

Andre Fedd, Jennifer Anne Samp, Colter Ray

Subject: Social Sciences, Gender And Sexuality Studies Keywords: Sex Talk, Communicative Processes, Theory Development, Interpersonal Relationships, Sexual Behaviors

Online: 4 March 2024 (09:52:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0008.v1

Factors Associated with Extended Length of Stay for Paediatric Mental Health Presentations to Emergency Departments in South Western Sydney, Australia

Jahidur Rahman Khan, James Rufus John, Paul M. Middleton, Yao Huang, Ping-I Lin, Nan Hu, Bin Jalaludin, Paul Chay, Raghu Lingam, Valsamma Eapen

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: extended length of stay; emergency department; mental health

Online: 1 February 2023 (06:01:41 CET)

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Background: Evidence suggests that children and young people (CYP) who present to the emergency department (ED) for mental health (MH) difficulties may have extended lengths of stay (LOS); however, there is a paucity of research in Australia regarding the factors associated with extended LOS. This study aimed to determine the factors associated with extended LOS for paediatric MH-related presentations to the EDs in South Western Sydney (SWS), a multicultural community in Australia. Methods: We analysed electronic medical records (eMR) of 7,409 MH-related ED encounters of CYP aged 0 up to 18 years from all six public hospitals in SWS from January 2016 to April 2022. Extended LOS was defined as encounters of more than 4 hours. We assessed factors associated with extended LOS using a multilevel logistic regression model, accounting for hospital-level clustering. Results: Approximately 57.6% of all ED presentations for paediatric MH involved extended LOS. ED presentations by adolescents (adjusted odds ratio (AOR) 2.23, 95% CI 1.20-4.17 for 12-14 years and AOR 2.69, 95% CI 1.44-5.00 for 15-17 years), and patients with a preferred language other than English (AOR 1.47, 95% CI 1.15-1.89) had increased odds of extended LOS compared to their counterparts. Deliberate self-harm related presentations, the most commonly presented MH condition, had higher odds of extended LOS than other MH-related presentations (AOR 1.77, 95% CI 1.59-1.98). Patients with MH presentations that required urgent evaluation (triage levels 1-2) had higher odds of extended LOS (AOR 1.38, 95% CI 1.15-1.65) compared to triage level 3, whereas those with triage levels 4-5 had lower odds (AOR 0.66, 95% CI 0.58-0.74). Further, patients with MH-related presentations that came by ambulance (compared to other mode of presentations) and presentations that happened at night and late at night (compared to early morning and daytime presentations). The odds of extended LOS were considerably lower during the COVID-19 period compared to the pre-COVID-19 period (AOR 0.74, 95% CI 0.67-0.82). Additionally, extended paediatric LOS for MH issues in the ED showed notable hospital-level heterogeneity. Conclusion: A large proportion of extended LOS in ED and sociodemographic disparities reflect inequality in access to paediatric MH care. Our findings highlight the need for equitable distribution of resources directed towards at-risk CYP to improve MH outcomes and reduce health system burden.

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