Chemical analysis of the organic components in beers has applications to quality control, authenticity and improvements to the flavor characteristics and brewing process. This study aims to show the complementary nature of two instrumental techniques which in combination can identify and quantify the majority of organic components in a beer sample. Nuclear Magnetic Resonance (NMR) was used to provide concentrations of twenty five different organic compounds including alcohols, organic acids, carbohydrates, and amino acids. Calorie content was also estimated for the samples. NMR data for ethanol concentrations were validated by comparison to a Fourier Transform Infrared Spectrometry (FTIR) method. Headspace Solid-Phase Microextraction (SPME) Gas Chromatography Mass Spectrometry (GCMS) was used to identify a range of volatile compounds such as alcohols, esters and hop derived aroma compounds. A simple and inexpensive conversion of a Gas Chromatography Flame Ionization Detector (GC FID) instrument to allow the use of Solid-Phase Microextraction was found to be useful for the quantification of volatile esters.

Ensembles of Species Distribution Models (SDMs) represent the geographic ranges of pathogen vectors by combining alternative analytical approaches and merging information on vector occurrences with more extensive environmental data. Biased collection data impact SDMs, regardless of the target species but no studies have compared the differences in the distributions predicted by the ensemble models when different sampling frameworks are used for the same species. We compared Ensemble SDMs for two important Ixodid tick vectors, Amblyomma americanum and Ixodes scapularis in mainland Florida, USA, when inputs were either convenience samples of ticks, or collections obtained using the standard protocols promulgated by the U.S. Centers for Disease Control and Prevention. The Ensemble SDMs for the convenience samples and standard surveys showed only a slight agreement (Kappa = 0.060, A. americanum; 0.053, I. scapularis). Convenience sample SDMs indicated A. americanum and I. scapularis should be absent from 34.5% and 30.9% of the state where standard surveys predicted the highest likelihood of occurrence of the respective vectors. Ensemble models from standard surveys predicted 81.4% and 72.5% (A. americanum and I. scapularis) of convenience sample sites. Omission errors by standard survey SDMs, of the convenience collections, frequently were associated with adjacency to at least one SDM or errors in geocoding algorithms that failed to correctly locate convenience samples. These geocoding errors emphasize commonly overlooked needs to explicitly evaluate and improve data quality for vector survey data used in spatial models.

JC polyomavirus (JCPyV) is a human-specific polyomavirus that establishes a silent lifelong infection in multiple peripheral organs, predominantly those of the urinary tract, of immunocompetent individuals. In immunocompromised settings, however, JCPyV can infiltrate the central nervous system (CNS), where it causes several encephalopathies of high morbidity and mortality. JCPyV-induced progressive multifocal leukoencephalopathy (PML), a devastating demyelinating brain disease, was an AIDS-defining disease pre-antiretroviral therapy that has “reemerged” as a complication of immunomodulating and chemotherapeutic agents. No effective anti-polyomavirus therapeutics are currently available. How depressed immune status sets the stage for JCPyV resurgence in the urinary tract, how the virus evades pre-existing antiviral antibodies to become viremic, and where/how it enters the CNS are incompletely understood. Addressing these questions requires a tractable animal model of JCPyV CNS infection. Although no animal model can replicate all aspects of any human disease, mouse polyomavirus (MuPyV) in mice and JCPyV in humans share key features of peripheral and CNS infection and antiviral immunity. In this review, we will discuss evidence suggesting how JCPyV migrates from the periphery to the CNS, innate and adaptive immune responses to polyomavirus infection, and how the MuPyV-mouse model is providing insights into the pathogenesis of JCPyV CNS disease.

Collisional mountain belts commonly develop intramontane basins from mechanical and isostatic subsidence during orogenic development. These frequently display a relict top surface, evidencing a change interval from basin infilling to erosion often via capture or overspill. Such surfaces provide markers that inform on orogenic growth patterns via climate and base level interplay. Here, we describe the top surface from the Sorbas Basin, a key intramontane basin within the Betic Cordillera (SE Spain). The surface is fragmentary comprising high elevation hilltops and discontinuous ridges developed onto the variably deformed final basin infill outcrop (Gochar Formation). We reconstruct surface configuration using DEM interpolation and apply ¹⁰Be/²⁶Al cosmonuclides to assess surface formation timing. The surface is a degraded Early Pleistocene erosional pediment developed via autogenic switching of alluvial fan streams under stable dryland climate and base level conditions. Base level lowering since the Middle Pleistocene focused headwards incision up interfan drainages, culminating in fan head capture and fan morphological preservation within the abandoned surface. Post abandonment erosion has lowered the basin surface by 31 m (average) and removed ~5.95 km³ of fill. Regional basin comparisons reveal a phase of Early Pleistocene surface formation, marking landscape stability following the most recent Pliocene-Early Pleistocene mountain building. Post-surface erosion rate quantification is low and in accordance with ¹⁰Be denudation rates typical of the low uplift Betic Cordillera.

This qualitative research explores the adoption of blockchain technology in supply chain management, aiming to understand the drivers, barriers, and implications associated with its integration. Through in-depth interviews and thematic analysis, insights are gathered from key stakeholders in the supply chain ecosystem. The findings reveal a complex landscape, with stakeholders recognizing blockchain's potential to enhance transparency, efficiency, and trust while acknowledging challenges related to technical complexities, regulatory uncertainties, and organizational barriers. Despite these challenges, participants express optimism about blockchain's transformative potential, citing opportunities for improved traceability, supply chain resilience, and sustainability. Collaboration, governance, and ecosystem development emerge as critical factors for driving blockchain adoption within supply chains, alongside the need for continuous education and capacity-building initiatives. Overall, the study underscores the importance of addressing challenges and fostering a culture of innovation and collaboration to unlock the full potential of blockchain-enabled supply chains.

This study explores the potential to reach a circular economy for post-consumer recycled polyethylene terephthalate (rPET) packaging and bottles by using it as a distributed recycling for additive manufacturing (DRAM) feedstock. Specifically, rPET is processed using only an open source toolchain with fused particle fabrication (FPF) or fused granular fabrication (FGF) processing. In this study, first the impact of granulation, sifting and heating (and their combination) is quantified on the shape and size distribution of the rPET flakes. Then feeding studies were performed to see if they could be printed through an external feeder or needed to be direct printed with a hopper using two Gigabot X machines, one with extended part cooling and one without. Print settings were optimized based on thermal characterization and for the latter which was shown to print rPET directly from shredded water bottles mechanical testing is performed. The results showed that geometry was important for extended feeding tubes and direct printed using a hopper. Further there is a wide disparity in the physical properties of rPET from water bottles depending on source and the history of the material. Future work is needed to enable water bottles to be used as a widespread DRAM feedstock.

Purpose. Moraxella is an ocular bacterial pathogen isolated in cases of keratitis, conjunctivitis, and endophthalmitis. Gram-negative brick-shaped diplobacilli from ocular specimens, and slow growth in culture, are early indications of Moraxella ocular infection; however, identifying Moraxella to species can be complex and inconsistent. Methods. In this study, bacteria consistent with Moraxella were identified to species using: 1) DNA sequencing coupled with vancomycin susceptibility, 2) MALDI-TOF Mass Spectrometry, and 3) Biolog ID System. Study samples consisted of 9 ATCC Moraxella controls, 82 isolates from keratitis, 21 isolates from conjunctivitis, and 4 isolates from endophthalmitis. Results. The ATCC controls were correctly identified. For keratitis, 66 (80.5%) were identified as M. nonliquefaciens, 7 (9.0%) as M. lacunata, 5 (6%) as M. osloensis, 2 (2.5%) as Acinetobacter lwoffi, 1 (1.0%) as M. bovis/nonliquefaciens, and 1 (1.0%) as M. osloensis/nonliquefaciens. For conjunctivitis, 9 (43.0%) were identified as M. osloensis, 6 (29.0%) as M. nonliquefaciens, 3 (14.3%) as Roseomonas, 2 (9.5%) as Acinetobacter (parvus, junii), and 1 (4.5%) as M. catarrhalis/M. nonliquefaciens. From endophthalmitis, 3 of 4 of the isolates were M. nonliquefaciens. Overall, M. nonliquefaciens and M. osloensis were identified in 70% (75 of 107) and 13% (14 of 107) of cases, respectively, totaling 83% (89 of 107). Conclusions. M. nonliquefaciens and M. osloensis are important bacterial pathogens of the eye as determined by DNA sequencing, MALDI-TOF MS, and Biolog. Although Moraxella catarrhalis is a clinical pathogen, other species of Moraxella appear to have a prominent role in eye infections.

This research investigates the challenges and opportunities associated with supply chain transparency and traceability in the renewable energy sector. Using a qualitative methodology, the study involved semi-structured interviews with key stakeholders, including industry experts, supply chain managers, regulatory officials, and NGO representatives. The findings reveal that the complexity and global span of renewable energy supply chains pose significant hurdles for ensuring transparency and traceability. Variability in the maturity of traceability systems across companies further complicates the landscape, with some companies benefiting from advanced systems while others struggle with cost and technical barriers. Technological advancements, especially blockchain, offer promising solutions but require standardization and scalability to be effective. Regulatory frameworks play a crucial role, yet inconsistencies across jurisdictions create compliance challenges, underscoring the need for harmonized standards. Collaboration and partnerships are essential, providing platforms for sharing best practices and developing common standards. Enhanced transparency can lead to operational efficiencies, improved consumer trust, and stronger market positioning. Integrating sustainability into supply chain practices is fundamental, aligning with the increasing emphasis on ESG criteria among investors and stakeholders. Education and capacity-building, particularly for suppliers in developing countries, are vital for promoting transparency. Leadership and corporate culture are critical in driving these efforts, with strong commitment from the top necessary to implement effective practices. This study contributes valuable insights for stakeholders in the renewable energy sector, offering a foundation for future research and policy development aimed at advancing sustainable and ethical supply chain practices. The findings highlight the need for a holistic approach that integrates transparency and traceability into broader sustainability and business strategies.

Purpose: The purpose of this study is to further explore how e-loyalty and E-marketing influences E-trust and satisfy the demand by offering fresh perspectives based on research as well as emphasis on the factors influencing the E-trust such as culture as a mediator. This study not only contributed theoretically but also presented practical implementations. Design/methodology/approach: Online survey was used to obtain data by focusing the Hospitality sector (Hotel Industry) and verifying the conceptual framework. Data was collected in multiple time lags. Findings: Findings showed that the E-trust influenced by E-loyalty and E-Marketing. E-trust comes from the previous experiences, e-loyalty and e-marketing. Further, some trends such as culture influenced the e-trust. Research limitation/implications: The present study is quite suitable for those Researchers interested in learning more about the effects of E-loyalty and E-marketing on user E-trust and how to mitigate cultural influences can benefit from the current study. This research also has implications for those who wish to improve market allure and survival in digital world. This study focused on the hospitality sector (Hotel Industry) in China; however, the sector and geography could be altered to suit the needs of the study's participants. Practical implications: The present study delivers the practical guidelines which are quiet suitable for understanding the formation of E-loyalty, E-marketing, and E-trust through which specific E-marketing strategy can be designed to deal with the consumer’s E-loyalty and their expectations as per their Cultural perspective. At some particular regions/countries, cultural trends are more important than practical market. This research study practically showed that how culture changed the consumer set of mind. Originality/value: The relationship between E-loyalty, E-marketing, E-trust, specifically with the cultural influence in digital market has been the subject of few research.

Preeclampsia (PE) is associated with an increased risk of cardiovascular disease (CVD) in later life. Postpartum cardiovascular risk screening could identify patients who would benefit most from lifestyle interventions. However, there are no readily available methods to identify these high-risk women. We propose that placental lesions may be useful in this regard. Here, we sought to determine the association between placental lesions and lifetime CVD risk. Placentas from 85 PE women were evaluated for histopathological lesions. At 6 months postpartum, a lifetime cardiovascular risk score was calculated. Placental lesions were compared between CVD risk groups and the association was assessed using odds ratios. Multivariable logistic regression was used to develop prediction models for CVD risk with placental pathology. Placentas from high-risk women had more severe lesions of maternal vascular malperfusion (MVM) and resulted in a 3-fold increased risk of screening high-risk for CVD (OR 3.10[1.20-7.92]) compared to women without these lesions. MVM lesion severity was moderately predictive of high-risk screening (AUC 0.63[0.51,0.75]; sensitivity 71.8%[54.6,84.4]; specificity 54.7%[41.5,67.3]. When clinical parameters were added, the model’s predictive performance improved (AUC 0.73[0.62,0.84]; sensitivity 78.4%[65.4,87.5]; specificity 51.6%[34.8,68.0]. The results suggest that placenta pathology may provide a unique modality to identify women for cardiovascular screening.

With the burgeoning growth of online retail, the issue of counterfeit products has become a significant threat to both consumer trust and brand integrity, posing challenges to sustainable market practices. Online retail platforms are promoted to redesign their channel structures and enhance brand traceability to tackle counterfeits using blockchain technology. To investigate the interactions between blockchain technology and the channel structures of online retail platforms, we design a game theory model incorporating a manufacturer with(out) blockchain participation selling products via an online retail platform that operates an agency channel and/or a reselling channel. We show that the critical trade-off of blockchain participation comprises the brand assurance effect of the blockchain, the channel competition intensification effect, and the blockchain adoption cost. The platform is capable of strategically designing the channel structure to encourage (while discouraging) blockchain participation by the manufacturer. Our analysis highlights the complementarity between blockchain participation and the channel structure. Furthermore, the effect of the consumer’s belief in the reselling channel, the commission fee in the agency channel, and the substitutability between channels are investigated in depth. The research provides valuable insights for online retail platforms and policymakers seeking to foster a sustainable and trustworthy e-commerce ecosystem.

Social media giants like Facebook are struggling to keep up with fake news, in the light of the fact that disinformation diffuses at lightning speed. For example, the COVID-19 (i.e. Coronavirus) pandemic is testing the citizens' ability to distinguish real news from falsifying facts (i.e. disinformation). Cyber-criminals take advantage of the inability to cope with fake news diffusion on social media platforms. Fake news, crafted as a means to manipulate readers to perform various malicious IT activities. However, no previous study has investigated the strategies used to create fake news on social media. Therefore, we have analysed five data-sets that contain online news articles (i.e. both fake and legitimate news) to investigate strategies of crafting fake news on social media platforms. Our study findings revealed a threat model understanding strategies of crafting fake news which may highly likely diffuse on social media platforms.

This study explores the barriers and opportunities faced by women in supply chain leadership, a field traditionally dominated by men. Through in-depth interviews and thematic analysis, it uncovers the pervasive cultural and societal biases that undermine women's perceived competence and suitability for leadership roles. These biases, often rooted in deep-seated stereotypes, influence hiring and promotion decisions, creating significant obstacles for women. Structural and organizational barriers, such as the lack of formal diversity policies, flexible working arrangements, and adequate mentorship, further hinder women's career progression. The dual burden of professional and domestic responsibilities also disproportionately affects women, limiting their availability for work-related travel and extended hours, which are often required in supply chain roles. Despite these challenges, the study identifies several pathways to promote gender diversity in supply chain leadership. Organizational commitment to diversity and inclusion, flexible working policies, and comprehensive mentorship programs are crucial in supporting women's advancement. Education and professional development opportunities are essential in equipping women with the necessary skills for leadership roles. Additionally, fostering an inclusive corporate culture that values diverse perspectives and addresses discrimination is vital for creating a supportive environment. Broader societal and policy-level changes, such as government and industry initiatives promoting gender diversity, are also necessary. The integration of emerging areas like sustainability, entrepreneurship, emotional intelligence, marketing, and supplier relationship management offers new opportunities for women to contribute to the industry's evolution. By addressing these barriers and leveraging the identified opportunities, it is possible to create a more inclusive and equitable supply chain industry, benefiting both the industry and society.

Insect herbivores have a wide range of life cycles and feeding habits, making them extremely diverse. With their host plants, they form close relationships and suppress their defense mecha-nisms. Molecular elicitors are the key bio-elements in detection and recognition of attacking enemies in tissue consumption. Insect oral secretion, frass, and fluid of egg deposition contain bio-logical active molecules called herbivore-associated elicitors (HAEs) are recognized by pattern recognition receptors (PRRs). However, in insect herbivores, little is known about the molecular basis of signal transduction and regulation of plant resistance. Many plants distinguish insect feeding from wounding by HAEs presenting in their oral secretions (OS) and induce local and systemic responses against arthropod feeding. PRRs perceive HAEs in the oral secretion of cater-pillars in a species-specific manner to elicit exclusive defense responses. HAEs-PRRs interactions induce plant resistance by reprogramming plant metabolism and transcriptional machinery. Quantitative, timely, and coordinated plant response initiate early signalling events including Ca+2, reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs). We have discussed how early signalling cascades converge into the accumulation of phytohormones that regulate down-stream special metabolites against herbivores. In this review, we have drawn a hypothetical model of PPRs-HAEs mediated induced responses in plants and discussed how PRRs-HAEs interactions based on molecular mechanism that elicit short- and long-term induced defenses in plants. The identification of plant target insect herbivore PRRs-HAEs interactions will help to explore the fundamental molecular mechanisms of host manipulation and may generate prospects to develop novel pest resistance strategies.

This qualitative study explores consumer perceptions of ethical supply chains and their implications for brand loyalty in contemporary markets. Ethical supply chain practices, encompassing sustainability, transparency, and social responsibility, are increasingly pivotal in shaping consumer attitudes and behaviors. A semi-structured interview approach was utilized to gather insights from a diverse sample of consumers, revealing nuanced perspectives on how ethical considerations influence brand preferences and loyalty. Findings indicate that consumers value brands that demonstrate genuine commitment to ethicality, viewing transparency and accountability in supply chain operations as essential for building trust and credibility. Emotional responses such as admiration and respect were commonly associated with brands perceived as ethical, highlighting the emotional resonance of ethical supply chain practices in consumer decision-making processes. Challenges such as greenwashing and perceived discrepancies between brand promises and actions underscore the importance of authentic communication in aligning consumer perceptions with brand behaviors. The COVID-19 pandemic further emphasized the role of ethical supply chains in ensuring business resilience and consumer trust during global disruptions. Brands that exhibited ethical leadership during the crisis reinforced their reputational capital and strengthened relationships with ethically conscious consumers. This study contributes to understanding the strategic imperative for businesses to integrate and communicate ethical supply chain practices effectively, thereby fostering sustainable competitive advantages and enhancing long-term brand loyalty. Future research directions include exploring evolving consumer expectations, emerging ethical challenges, and innovative strategies for embedding ethicality into supply chain management.This qualitative study explores consumer perceptions of ethical supply chains and their implications for brand loyalty in contemporary markets. Ethical supply chain practices, encompassing sustainability, transparency, and social responsibility, are increasingly pivotal in shaping consumer attitudes and behaviors. A semi-structured interview approach was utilized to gather insights from a diverse sample of consumers, revealing nuanced perspectives on how ethical considerations influence brand preferences and loyalty. Findings indicate that consumers value brands that demonstrate genuine commitment to ethicality, viewing transparency and accountability in supply chain operations as essential for building trust and credibility. Emotional responses such as admiration and respect were commonly associated with brands perceived as ethical, highlighting the emotional resonance of ethical supply chain practices in consumer decision-making processes. Challenges such as greenwashing and perceived discrepancies between brand promises and actions underscore the importance of authentic communication in aligning consumer perceptions with brand behaviors. The COVID-19 pandemic further emphasized the role of ethical supply chains in ensuring business resilience and consumer trust during global disruptions. Brands that exhibited ethical leadership during the crisis reinforced their reputational capital and strengthened relationships with ethically conscious consumers. This study contributes to understanding the strategic imperative for businesses to integrate and communicate ethical supply chain practices effectively, thereby fostering sustainable competitive advantages and enhancing long-term brand loyalty. Future research directions include exploring evolving consumer expectations, emerging ethical challenges, and innovative strategies for embedding ethicality into supply chain management.

Supply chain transparency and traceability have become increasingly important in today's globalized and interconnected business environment. This qualitative research explores the challenges and perspectives of industry practitioners regarding supply chain transparency and traceability. Drawing on semi-structured interviews with a diverse group of supply chain professionals, the study identifies key themes including difficulties in achieving visibility beyond immediate suppliers, data fragmentation and inconsistency, barriers to technology adoption, regulatory compliance, cultural and organizational factors, impacts on supplier relationships, and the influence of the COVID-19 pandemic and sustainability goals. The findings highlight the complex nature of these challenges and the need for collaborative, multi-stakeholder approaches to address them effectively. Despite the challenges, the study also reveals the potential benefits of transparency and traceability for enhancing supply chain resilience, sustainability, and stakeholder trust. Moving forward, companies must leverage technological innovations, establish clear communication channels with suppliers, navigate regulatory complexities, and foster a culture of transparency and accountability within their organizations. Future research should focus on practical strategies for implementing transparency and traceability initiatives, as well as evaluating their impact on supply chain performance and sustainability outcomes.

The abstract of the study on the challenges and opportunities of supply chain digitalization encapsulates the primary findings and their implications from the perspectives of industry leaders. This qualitative research investigated how senior executives across diverse sectors perceive and manage the transition to digital supply chains. Interviews with twenty industry leaders revealed key challenges such as data integration, cybersecurity, organizational resistance, and financial constraints. Data integration issues were particularly pronounced, as participants struggled with unifying disparate data sources from legacy and modern systems, creating barriers to achieving cohesive digital frameworks. Cybersecurity emerged as a critical concern due to the increased vulnerability of digital supply chains to cyber threats, necessitating robust and proactive security measures. Organizational resistance, driven by employee apprehensions about job displacement and technological unfamiliarity, highlighted the need for effective change management practices, including clear communication and training. Financial constraints, especially for small and medium-sized enterprises (SMEs), underscored the difficulty of justifying the substantial investments required for advanced digital technologies. Despite these challenges, the study identified significant opportunities associated with digitalization, including enhanced operational efficiency, improved visibility, predictive analytics, and better customer satisfaction. Digital tools were found to streamline processes, reduce manual intervention, and provide real-time insights into supply chain performance, thus facilitating more informed decision-making and swift responses to disruptions. The accelerated adoption of digital technologies during the COVID-19 pandemic demonstrated their essential role in enhancing supply chain resilience and agility. Additionally, the integration of sustainability goals through digitalization supported resource optimization and waste reduction, aligning with broader corporate social responsibility objectives. The findings suggest that while the path to digital transformation is complex, the benefits of improved efficiency, decision-making, customer satisfaction, and sustainability present compelling incentives for organizations to invest in and embrace digital supply chain solutions.

This study explores the role of stakeholder engagement in enhancing supply chain sustainability within the renewable energy sector. Through a qualitative research approach, including in-depth interviews with key stakeholders such as government agencies, industry associations, renewable energy companies, community groups, and environmental organizations, the research reveals the complexity and significance of effective stakeholder engagement. Stakeholders highlighted diverse motivations, including environmental, social, economic, and regulatory concerns, driving their participation. The study underscores the importance of tailored engagement strategies that recognize stakeholder heterogeneity and address specific needs and expectations. Collaborative approaches, such as public-private partnerships and multi-stakeholder initiatives, were identified as crucial for pooling resources, sharing knowledge, and addressing common challenges. However, challenges related to power imbalances, conflicting interests, and communication barriers were also noted. Government policies and regulatory frameworks were found to play a pivotal role in shaping stakeholder engagement practices and sustainability outcomes. Regulatory uncertainty and inconsistency were cited as significant concerns that could undermine sustainability initiatives. Community engagement emerged as a critical factor, with local communities often directly impacted by renewable energy projects. Meaningful engagement, including consultation and benefit-sharing mechanisms, is essential for building trust and securing social acceptance. Emotional intelligence and marketing strategies were recognized as important tools for effective stakeholder engagement, emphasizing the role of empathy, active listening, and clear communication. The findings of this study highlight the need for a holistic and integrated approach to stakeholder engagement and supply chain sustainability in the renewable energy sector. By addressing diverse stakeholder needs, fostering collaboration, and aligning policies with sustainability goals, stakeholders can work together to accelerate the transition towards a more sustainable energy future.

Sexual issues and treatment side effects are not routinely discussed with men receiving treatment for prostate cancer and support to address these concerns is not consistent across settings. This study evaluates a brief e-learning resource designed to improve sexual wellbeing support and examine its effects on healthcare professionals’ sexual attitudes and beliefs. Healthcare professionals (n=44) completed an online questionnaire at baseline which included a modified 12-item sexual attitudes and beliefs survey (SABS). Follow-up questionnaires were completed immediately after the e-learning and at 4 weeks. Data were analysed using one-way, repeat measures ANOVAs to assess change in attitudes and beliefs over time. Significant improvements were observed at follow-up for a number of survey statements including ‘knowledge and understanding’, ‘confidence in discussing sexual wellbeing’ and the extent to which participants felt ‘equipped with the language to initiate conversations’. The resource was seen as concise, relevant to practice, and as providing useful information on potential side effects of treatment. Brief, e-learning has potential to address barriers to sexual wellbeing communication and promote delivery of support for prostate cancer survivors. Practical methods and resources should be included with these interventions to support implementation of learning and long-term changes in clinical behaviour.

This paper presents a novel sensor for the detection and characterization of regions of air turbulence that would be of use to improve UAV stability in bad weather. It consists of a combined Schlieren imager and a Radar Acoustic Sounding System (RASS) to produce dual modality “images” of air movement within the measurement volume. The ultrasound modulated Schlieren imager consists of a strobed point light source, parabolic mirror, light-block and camera which are controlled by two laptops. It provides a fine scale projection of the acoustic pulse modulated air turbulence through the measurement volume. The narrow beam 40 kHz/ 17 GHz RASS produces spectra based on Bragg enhanced Doppler radar reflections from the acoustic pulse as it travels. Tests using artificially generated air vortices showed some disruption of the Schlieren image and of the RASS spectrogram. This should allow the higher resolution Schlieren images to identify the turbulence mechanisms that are disrupting the RASS spectra.

Electronic waste generation has been following a continuously rising trend. With electronics containing a myriad of materials some of which are hazardous, toxic, extremely rare or precious combined with more stringent legislative laws which encourage the reuse and optimised recycling of the materials included in e-waste, the need for a holistic approach is inevitable. Such an approach should not only identify the materials found in the various types of e-waste and their respective quantities but also needs to highlight the possible handling techniques and their respective impacts and associated hazards whether to the environment or human health. Performing such a task manually would be exasperating and costly while requiring extensive resources which might not be met with a justifiable economic gain; thus, the use of the advancement in computational sustainability to draw a complete picture and aid in an informed decision-making process is crucial. The e-waste ontology developed in this paper is one way of addressing the problem since it covers the treatment domain, the hazard and the materials contained within the different types of e-waste. The ontology developed can be used directly from the protégé software or by embedding it into a developed Decision Support System.

Mate crime is a specific subset of hate crime in which the perpetrator is known to the victim. To date, there is very little research into the perception and experience of mate crime in autism. The aim of the current study was to examine perceptions of friendship and mate crime in autistic adults, using semi-structured interviews. Five adults were interviewed about their experiences of social interactions, friendships and mate crime. Participants described distancing themselves from the ‘disability’ label whilst growing up to avoid condescension and being perceived as vulnerable, whilst learning to camouflage their social difficulties. Feelings of anxiety were associated with socialising, and participants valued relationships that did not place too many overwhelming demands on their time or energy. Finally, all participants had prior experiences of bullying. They understood the concept of mate crime but were unsure as to whether they would be able to identify it in their own lives if it occurred. However they could identify potential support networks in close friends and family. Results highlight the importance of further research into positive and negative aspects of social relationships in autistic adults, and the need to provide support to those who are socially vulnerable.

In some parts of Nigeria, many girls do not attend school, and among those sent to school, many still drop out early. This and other socio-cultural factors affect girls psychologically. There is no doubt that girls need consistent love and tutoring to guide them through the turbulent teen years and beyond. They need a mentor who acts as a friend and a role model. The Mobile-based Mentoring Platform seeks to leverage on mobile technology's affordances to focus on the needs of the girl-child, such as improvement in academic achievement, guidance in career choice, development of self-concept, and esteem. The girl-mentees comments revealed that using the platform provided them frequent access to mentors and access to learning opportunities. The challenges they faced include epileptic internet network, intrusions by parents, and others. Therefore, this paper examined the challenges and benefits of mentoring girls via a mentoring platform.

The detection of waste plastics in the marine and terrestrial environment using satellite Earth Observation data offers the possibility of large-scale mapping, and reducing on-the-ground manual investigation. In addition, costs are kept to a minimum by utilizing free-to-access Copernicus data. A Machine Learning based classifier was developed to run on Sentinel-1 and -2 data. In support of the training and validation, a dataset was created with terrestrial and aquatic cases by manually digitizing varying landcover classes alongside plastics under the sub-categories of greenhouses, plastic, tyres and waste sites. The trained classifier, including an Artificial Neural Network and post-processing decision tree, was verified using five locations encompassing these different forms of plastic. Although exact matchups are challenging to digitize, the performance has generated high accuracy statistics, and the resulting land cover classifications have been used to map the occurrence of plastic waste in aquatic and terrestrial environments.

This article aims to understand the role of tacit knowledge in call center organizations with the objective of understanding how call center representatives use tacit knowledge in their job roles and functions. Extant literature has focused on explicit knowledge but the research on tacit knowledge is still underdeveloped. The complexities and difficulties of the call center job role and the usage and transfer of knowledge is reviewed. Also, it takes into considerations past literature on tacit knowledge, how these respondents employ tacit knowledge in efficiently handling customers, responding to their queries, and engaging this form of knowledge in problem solving. The article concludes with discussion and implications for call center organizations and responders.

On using a 3D model to teach students a topic in astronomy, feedback was evaluated via a questionnaire. Analysis of students' responses to the questions revealed that user interface had a significant impact on their attitudes, which in turn could increase users' willingness to use immersive technology in e-learning. The results also showed that improving visual features through immersive technology and augmented reality tools were effective. The results confirm all hypotheses about positive relationships between facilitating conditions and usability of metaverse technology for students' attention and study motivation.

Current VAT rules for cross-border e-commerce companies in the EU are not sustainable, because they are extremely complex and often opaque, due to the lack of tax harmonization. The aim of the research is to explore, using a qualitative method, what kind of harmonization would make the current legislation more uniform, simpler, more transparent, and easier to understand, without conflicting with the rules of any Member State. To this end, the aspects of the new platform regulation introduced on 1 July 2021 and its potential for expansion are assessed through information from possible sales models. The research suggests that the rules on platforms do not cover all possible sales models, which in our view imposes an unnecessary extra administrative burden on some businesses and makes their tax activities less transparent. In the light of the results of the research, we propose that the current EU platform regulation should be extended to cover B2B, B2C transactions and services. As a result of this suggested harmonization, a simpler, more transparent, uniform and sustainable tax system would contribute to the whitening of the economy, generating additional tax revenue for Member States.

Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide, accounting for approximately 25% of deaths among pregnant women. We previously reported that pregnancy serum facilitates HEV replication in vitro. However, the differences in host cells with HEV infection induced by pregnancy serum and fetal bovine serum (FBS) are unclear. In this study, differentially expressed proteins were identified in HEV-infected hepatoma cells (HepG2) supplemented with different sera by using isobaric tags for relative and absolute quantitation. Proteomic analysis indicated that HEV infection significantly induced 1014 differentially expressed proteins in HEV-infected HepG2 cells when supplemented with FBS compared with pregnancy serum. Further validation by Western blot confirmed that filamin A, heat-shock proteins 70 and 90, Cytochrome c, and Thioredoxin were associated with HEV infection. This comparative analysis provides an important basis to further investigate HEV pathogenesis in pregnant women and HEV replication.

Can investing in women’s agriculture increase productivity? This paper argues that it can. We assess climate impacts and gender bias on women’s production in the global South and North and challenge the male model of agricultural development to argue further that women’s farming approaches can be more sustainable. Level-based analysis (global, regional, local) draws on literature review, including authors’ published longitudinal field research in Ghana and the United States. Women farmers are shown to be undervalued and to work harder, with fewer resources, for less compensation; gender bias challenges are shared globally while economic disparities differentiate; breaches of distributive, gender, and intergenerational justices as well as compromise of food sovereignty affect women everywhere. We conclude that investing in women’s agriculture needs more than standard approaches of capital and technology investment. Effective ‘investment’ would include systemic interventions into agricultural policy, governance, education, and industry; be directed at men as well as women; and use gender metrics, e.g. quotas, budgets, vulnerability and impacts assessments, to generate assessment reports and track gender parity in agriculture. Increasing women’s access, capacity, and productivity cannot succeed without men’s awareness and proactivity. Systemic change can increase productivity and sustainability.

The shift towards autonomous excavators in construction and mining is a significant leap towards enhancing operational efficiency and ensuring worker safety. However, it presents challenges such as the need for sophisticated decision-making and environmental perception due to complex terrains and diverse conditions. Our study introduces the E-GTN framework, a novel approach tailored for autonomous excavation that leverages advanced multisensor fusion and a custom-designed convolutional neural network to address these challenges. Results demonstrate that GridNet effectively processes grid data, enabling the reinforcement learning algorithm to make informed decisions, thereby ensuring efficient and intelligent autonomous excavator performance. The study concludes that the E-GTN framework offers a robust solution for the challenges in unmanned excavator operations, providing a valuable platform for future advancements in the field.

Liposomes have been used for several decades for the encapsulation of drugs and bioactives in cosmetics and cosmeceuticals. On the other hand, the use of these phospholipid vesicles in food applications is more recent and has been increasing significantly in the last ten years. Although in different stages of technological maturity - in the case of cosmetics, many products are on the market - processes to obtain liposomes suitable for the encapsulation and delivery of bioactives are highly expensive, especially aiming at scaling-up. Among the bioactives proposed for cosmetics and food applications, vitamins are the most frequently used. Despite the differences between the administration routes (oral for food and mainly dermal for cosmetics), some challenges are very similar (e.g., stability, bioactive load, average size, increase of drug bioaccessibility and bioavailability). In the present work, a systematic review of the technological advancements in the nanoencapsulation of vitamins using liposomes and related processes was performed; challenges and future perspectives were also discussed in order to underline the advantages of these drug loaded biocompatible nanocarriers for cosmetics and food applications.

This study explores the barriers to adopting green supply chain practices from the perspective of industry leaders. By conducting qualitative interviews with key decision-makers in various sectors, the research uncovers the complexities and challenges faced in integrating sustainable practices into supply chain operations. The findings highlight significant obstacles such as cost implications, lack of regulatory support, technological limitations, and resistance to change within organizations. Additionally, the study reveals that while there is a growing awareness and commitment towards sustainability, practical implementation remains fraught with difficulties. The insights gained from industry leaders provide a nuanced understanding of the multifaceted nature of these barriers, offering valuable guidance for businesses and policymakers aiming to promote greener supply chains.

Trust plays a pivotal role in supplier-buyer relationships, influencing decision-making, collaboration dynamics, and organizational performance. This qualitative study explores the multifaceted nature of trust in supplier-buyer relationships across diverse industries. Through in-depth interviews and thematic analysis, the study examines how trust develops, evolves, and impacts business interactions. Participants from various organizational settings provided insights into the cognitive, affective, and behavioral dimensions of trust, highlighting its role as a strategic asset in fostering resilience and competitive advantage. Findings underscored the importance of transparency, communication, and shared values in building trust, with emotional bonds and cultural compatibility enhancing partnership longevity and mutual commitment. Challenges such as asymmetrical power dynamics, economic uncertainties, and regulatory pressures were identified as barriers to trust, necessitating proactive strategies and ethical standards to mitigate risks. Practical implications include promoting open communication, aligning incentives, and cultivating a culture of trust within supply chains to enhance operational efficiencies and innovation. Future research could explore the impact of digitalization, technological advancements, and cross-cultural differences on trust dynamics, further enriching our understanding of effective relationship management in global markets. By addressing these complexities and leveraging trust as a foundational element, organizations can navigate uncertainties and capitalize on opportunities for sustainable growth and collaboration in dynamic business environments.

This study investigates green logistics strategies adopted by businesses to enhance sustainability within their supply chains, particularly focusing on reducing carbon footprints and environmental impacts associated with transportation and distribution activities. Through qualitative analysis and interviews with supply chain managers, industry experts, and sustainability officers, this research provides insights into motivations, strategies, challenges, and benefits related to green logistics practices. Key findings highlight the critical role of aligning green logistics with corporate sustainability goals. Advanced technologies such as telematics, GPS tracking, and data analytics are instrumental in optimizing transportation routes, reducing fuel consumption, and minimizing emissions. Additionally, strategies like using eco-friendly vehicles, energy-efficient warehouse operations, and implementing reverse logistics are identified as effective means to mitigate environmental impacts. Collaboration and partnerships with suppliers, logistics providers, and stakeholders are essential for sharing best practices and fostering joint initiatives. Despite benefits such as cost savings and enhanced corporate reputation, challenges include high initial investments, the absence of standardized metrics for environmental impact, and regulatory complexities. However, regulatory compliance also acts as a driver for green logistics adoption and presents opportunities for improving sustainability performance. The integration of sustainability goals with logistics strategies underscores the interdisciplinary nature of sustainable supply chain management. This holistic approach encompasses aspects of entrepreneurship, emotional intelligence, marketing, and supplier relationship management.

The dynamic and unpredictable nature of modern supply chains necessitates the development of resilient systems capable of withstanding various disruptions. This qualitative study examines the impact of collaborative practices on supply chain resilience, providing an in-depth analysis of their contributions to the robustness and adaptability of supply chains. Through extensive interviews with industry professionals, including supply chain managers, logistics coordinators, and strategic planners, the study identifies key collaborative practices—such as information sharing, joint decision-making, and coordinated response strategies—that significantly enhance resilience. These practices facilitate proactive risk management, improve response times during disruptions, and foster innovation through shared knowledge and resources. Thematic analysis of the collected data reveals that strong relationships among supply chain partners and integrated approaches that leverage each participant's strengths are crucial for effective risk mitigation and recovery. Additionally, the study underscores the role of technology in enabling real-time information sharing and decision-making, which are essential for effective collaboration. The findings highlight the importance of investing in robust collaborative networks and adopting supportive technologies to enhance communication and coordination. This research contributes to the existing body of knowledge by offering a nuanced understanding of how strategic implementation of collaborative practices can build more resilient supply chains. It provides practical recommendations for businesses seeking to improve their resilience, emphasizing the qualitative aspects of collaboration and its impact on supply chain management. Overall, this study presents a comprehensive exploration of how collaboration can bolster supply chain resilience, offering valuable insights for practitioners and scholars focused on creating stable and sustainable supply chain operations in the face of growing uncertainties.

This qualitative investigation delves into the intricate interplay of cultural factors within supply chain integration, aiming to elucidate how diverse cultural dimensions shape communication dynamics, decision-making processes, and collaborative efforts among global supply chain practitioners. Employing a phenomenological approach, the study explores the lived experiences and subjective perceptions of supply chain managers and professionals, providing nuanced insights into the profound impact of national culture, organizational culture, digital technologies, and sustainability considerations on supply chain operations. Key findings highlight the significant influence of national culture, as conceptualized by Hofstede's cultural dimensions, on supply chain interactions. These dimensions—such as power distance, individualism versus collectivism, uncertainty avoidance, and masculinity versus femininity—play crucial roles in shaping how individuals perceive authority, manage risks, negotiate agreements, and engage in collaborative practices across diverse cultural contexts. Cultural norms and values deeply influence both intra-organizational dynamics and inter-organizational relationships within global supply chains. Organizational culture emerges as a pivotal determinant of supply chain integration success. Cultures characterized by transparency, trust, inclusivity, and a commitment to continuous improvement create environments conducive to effective cross-border collaboration. Conversely, organizations with conflicting or ambiguous cultural norms face challenges in aligning goals, fostering mutual understanding, and maintaining open communication channels with international partners. The study underscores the transformative role of digital technologies in enhancing supply chain management practices. Technologies such as blockchain, artificial intelligence, and the Internet of Things improve supply chain visibility, optimize operations, and enhance decision-making processes, strengthening resilience against disruptions. The adoption and integration of these technologies depend on organizational readiness, technological capabilities, and cultural acceptance within supply chain networks. Cultural factors influence the adoption pace, implementation strategies, and utilization patterns of digital technologies, emphasizing the need for strategic alignment between technological investments and cultural norms to maximize their potential benefits. Furthermore, sustainability considerations are critical in shaping cultural values and priorities within supply chain networks. Organizations increasingly recognize the importance of environmental sustainability, ethical sourcing practices, and corporate social responsibility in shaping their reputations, stakeholder relationships, and long-term business goals. Cultural factors significantly influence organizations' approaches to sustainability, guiding their strategic decisions and operational practices.

In today's globalized economy, supply chain disruptions present significant challenges, impacting businesses' operational continuity and efficiency. This study delves into the ways businesses navigate these disruptions, with a particular emphasis on qualitative insights into risk management practices. The complexity and interconnectivity inherent in modern supply chains make them vulnerable to a broad spectrum of disruptions, ranging from natural disasters and geopolitical conflicts to technological failures and pandemics. Effective supply chain risk management requires a structured approach to identifying potential risks, evaluating their likelihood and potential impact, and formulating robust mitigation strategies. Employing a qualitative research methodology, this study gathers in-depth insights from semi-structured interviews with supply chain managers, industry experts, and executives. The findings underscore the necessity of proactive risk identification and comprehensive assessment processes. Advanced technologies, including artificial intelligence (AI), the Internet of Things (IoT), and blockchain, are highlighted as crucial tools for enhancing visibility and responsiveness within supply chains. Strategies such as diversifying suppliers and maintaining safety stock emerge as vital components of risk mitigation, ensuring supply continuity in the face of disruptions. Strong relationships with suppliers are pivotal, facilitating better information sharing and collaborative problem-solving. Leadership commitment to risk management and fostering a culture of resilience within organizations is also critical. Training programs and simulation exercises are identified as effective means of preparing employees to handle disruptions. Furthermore, adherence to regulatory compliance and a focus on sustainability are integral to maintaining long-term stability and reducing the risk of future disruptions.

The rapid evolution of technology has profoundly reshaped supply chain operations across various industries, compelling organizations to adapt swiftly to maintain competitive advantage. This qualitative study delves into the adaptive strategies that organizations employ to navigate the intricate landscape of digital transformation within their supply chains. By conducting comprehensive in-depth interviews with key stakeholders, including supply chain managers, technology officers, and operational staff, this research aims to uncover the multifaceted challenges, opportunities, and best practices associated with integrating digital technologies into supply chain operations. The findings of this study reveal that successful digital transformation in supply chains hinges on several critical factors. Leadership plays a pivotal role in steering the organization through the complexities of technological change, emphasizing the need for visionary and adaptive leaders who can drive strategic initiatives. Organizational culture, characterized by a willingness to embrace change and foster innovation, emerges as a significant enabler of digital transformation. Additionally, strategic planning and a clear roadmap are essential for aligning technological initiatives with business objectives and ensuring seamless integration. Employee training and development are identified as crucial elements in overcoming resistance to change and enhancing digital literacy among the workforce. The study highlights the importance of continuous learning and skill development programs to equip employees with the necessary competencies to leverage new technologies effectively. Furthermore, the research underscores the significance of collaboration and communication across different levels of the organization to foster a cohesive approach to digital transformation. Challenges such as data security concerns, substantial financial investments, and the complexity of integrating diverse technologies are also explored. The insights derived from the interviews provide a nuanced understanding of how organizations can address these challenges by adopting robust cybersecurity measures, securing adequate funding, and leveraging modular and scalable technological solutions. This research contributes valuable empirical insights into the digital transformation journey of supply chain operations, offering practical recommendations for practitioners and scholars. The implications of this study are far-reaching, providing a framework for organizations to navigate the digital landscape successfully. Key recommendations include fostering a culture of innovation, investing in leadership development, prioritizing employee training, and adopting a strategic and holistic approach to digital transformation.

The present qualitative study delves into the sustainability practices within supply chain management, emphasizing insights garnered from leading global firms. With sustainability becoming an imperative across industries, understanding how top firms integrate sustainable practices within their supply chains offers valuable lessons for broader implementation. The investigation draws on interviews, case studies, and existing literature to identify key strategies, challenges, and outcomes associated with sustainable supply chain management. Findings reveal a comprehensive approach involving the adoption of green technologies, ethical sourcing, and stakeholder engagement, all of which contribute to enhanced environmental and social performance. The discussion highlights the critical role of leadership, innovation, and collaboration in driving sustainability, underscoring the need for continuous improvement and adaptation. Ultimately, the study concludes that while significant progress has been made, ongoing efforts and commitment are essential for achieving long-term sustainability goals in supply chain management.

Supplier Relationship Management (SRM) is a critical aspect of supply chain management, particularly in today's dynamic and interconnected business environment. This qualitative research study explores SRM practices within the context of supply chain dynamics, aiming to understand how organizations manage their supplier relationships to achieve strategic objectives. Through semi-structured interviews, document analysis, and participant observation, key themes emerge, including collaboration, trust, risk management, performance measurement, digital technology integration, sustainability, cultural alignment, supplier development, strategic alignment, emotional intelligence, and marketing perspectives. The findings underscore the importance of collaboration and trust in fostering strategic partnerships with suppliers, mitigating risks, and enhancing supply chain resilience. Effective risk management practices, performance measurement systems, and digital technology integration are essential for improving transparency, efficiency, and responsiveness in SRM. Sustainability considerations highlight the need for aligning SRM practices with corporate social responsibility goals and stakeholder expectations. Cultural alignment, supplier development programs, strategic alignment, emotional intelligence, and marketing perspectives further enrich the understanding of how organizations navigate their supplier relationships. This study contributes to the body of knowledge on SRM by providing empirical insights into the practices, challenges, and opportunities associated with managing supplier relationships in dynamic supply chains. The findings offer valuable guidance for practitioners and policymakers seeking to enhance their SRM practices and achieve competitive advantage in today's complex business landscape.

This qualitative research explores the impact of digital transformation on supply chain collaboration, delving into its implications for organizational dynamics, processes, and outcomes. Through in-depth interviews with key stakeholders in diverse industries, insights are gathered into how digital technologies reshape collaboration within supply chains. Findings reveal a shift towards greater connectivity, visibility, and agility enabled by digital platforms and ecosystems, fostering innovation and value creation. However, challenges such as data security, organizational silos, and trust issues hinder the realization of collaborative potential. The study underscores the importance of embracing digital technologies, fostering a collaborative culture, and prioritizing trust and transparency to unlock the full benefits of digital collaboration. Moving forward, future research should focus on exploring evolving dynamics, identifying best practices, and developing frameworks for effective implementation in diverse organizational contexts. By leveraging digital transformation, organizations can enhance their supply chain capabilities, strengthen competitiveness, and drive sustainable growth in an interconnected, digitalized world.

This qualitative study investigates the adoption of Lean Principles in Supply Chain Management (SCM), aiming to explore the motivations, challenges, and outcomes associated with Lean implementation across diverse organizational contexts. Through semi-structured interviews and thematic analysis, insights were gleaned from stakeholders involved in SCM processes, revealing the critical role of organizational culture, leadership commitment, and strategic alignment in driving successful Lean initiatives. The findings underscore the importance of fostering a culture of continuous improvement, where employees are empowered to proactively identify and address inefficiencies. Leadership emerged as pivotal in setting the tone, providing resources, and championing Lean initiatives, while strategic alignment ensured integration with broader organizational goals and objectives. Operational practices and processes were central, highlighting the need for customization and contextual adaptation in Lean implementation. Despite the potential benefits, the outcomes and impact of Lean adoption varied depending on factors such as organizational maturity and industry context. The study also revealed broader cultural and organizational changes catalyzed by Lean adoption, fostering innovation, collaboration, and adaptability. In summary, this study contributes to our understanding of Lean adoption in SCM, offering practical insights for organizations seeking to enhance efficiency and competitiveness in today's dynamic business landscape.

Supply chain risk management (SCRM) is a critical aspect of contemporary business operations, necessitated by the complex and interconnected nature of global supply chains. This qualitative research delves into the intricacies of SCRM through in-depth interviews with industry experts, aiming to unravel the multifaceted nature of supply chain risks and the strategies employed for mitigation. Key themes emerged, including the diverse sources of risks encompassing operational, financial, environmental, and geopolitical factors, highlighting the need for a comprehensive approach to risk management. Challenges such as limited visibility, resource constraints, and organizational silos were identified, underscoring the importance of addressing these barriers to enhance SCRM effectiveness. Strategies for risk mitigation encompassed technological investments for enhanced visibility and predictive capabilities, collaboration and information sharing among supply chain partners, and the integration of sustainability principles into risk management practices. Leadership, organizational culture, and continuous learning emerged as critical factors in driving effective SCRM practices, emphasizing the need for proactive and adaptable approaches to navigate evolving risks. Overall, this study contributes to the existing body of knowledge on SCRM by providing valuable insights for practitioners and academics, and underscores the importance of holistic and proactive approaches to enhance supply chain resilience and agility in today's dynamic business environment.

This study explores the multifaceted role of culture in supply chain collaboration, focusing on how cultural differences shape communication, trust-building, negotiation, conflict resolution, risk management, and ethical standards. Utilizing a qualitative methodology, semi-structured interviews were conducted with 25 supply chain professionals from diverse cultural backgrounds and industries. The findings reveal that high-context cultures favor indirect communication and nuanced information exchange, which can lead to misunderstandings with partners from low-context cultures who prefer direct and explicit communication. Trust-building practices vary significantly, with high uncertainty avoidance cultures emphasizing formal agreements and procedural rigor, while low uncertainty avoidance cultures prioritize personal relationships and demonstrated reliability. Negotiation strategies also diverge, reflecting the underlying values of collectivism versus individualism, impacting the tactics and outcomes of supply chain negotiations. Conflict resolution approaches differ, with high power distance cultures favoring hierarchical and mediated solutions, and low power distance cultures preferring direct and egalitarian methods. The study highlights the need for adaptability to cultural changes and the development of cultural intelligence as essential competencies for managing cross-cultural supply chains. Additionally, cultural differences in risk management approaches and governance mechanisms affect the coordination and resilience of supply chains, while varying ethical standards influenced by cultural norms necessitate culturally sensitive strategies for promoting corporate social responsibility. The insights gained from this research underscore the importance of understanding and leveraging cultural differences to build stronger, more productive supply chain relationships, contributing to the broader literature on culture and supply chain management and offering practical implications for enhancing global supply chain collaboration.

Supply chain disruptions pose significant challenges to organizations, highlighting the critical importance of resilience in contemporary supply chains. This qualitative research explores the implications of supply chain disruptions on organizational resilience, drawing insights from interviews with supply chain managers and executives across various industries. The study identifies key factors that contribute to resilience, including agility, collaboration, risk management, strategic planning, technology integration, leadership, and organizational culture. Through thematic analysis, the research elucidates how these factors interact to enable organizations to manage and recover from disruptions effectively. Findings underscore the importance of agility in adapting to changing circumstances, collaboration with stakeholders to coordinate responses, and proactive risk management to anticipate and mitigate disruptions. Strategic planning and technology integration emerge as vital enablers of resilience, along with effective leadership and a resilient organizational culture that fosters adaptability and continuous improvement. The implications of supply chain disruptions extend beyond operational and financial impacts to include reputational and relational dimensions, emphasizing the importance of transparent communication and stakeholder engagement. The practical insights offered by this study provide guidance for organizations seeking to enhance their resilience and ensure continuity of operations in an increasingly complex and dynamic supply chain environment.

This study investigates the impact of information sharing on supply chain resilience by exploring the experiences and insights of supply chain professionals through qualitative research. Information sharing has become increasingly recognized as a vital component in enhancing the ability of supply chains to anticipate, respond to, and recover from disruptions. Through semi-structured interviews with 22 supply chain professionals across various industries, the study delves into the mechanisms through which information sharing influences supply chain resilience, the challenges faced, and the role of enabling factors such as technology and organizational culture. The findings reveal that effective information sharing enhances supply chain visibility, coordination, and adaptability. Enhanced visibility allows supply chain partners to monitor real-time operational data, facilitating early detection of potential disruptions. Improved coordination enables better alignment of activities, reducing inefficiencies and mitigating the bullwhip effect. Adaptability is bolstered through the timely exchange of information, allowing for rapid adjustments to changing conditions. However, the study also identifies significant barriers to effective information sharing, including concerns about data security, competitive advantage, and trust among partners. Trust and strong relationships emerge as critical factors for successful information sharing, highlighting the need to build and maintain trust to facilitate open communication. The role of technology is emphasized, with digital platforms, blockchain, and the Internet of Things (IoT) identified as key enablers of efficient and secure information exchange. The study concludes that fostering a supportive organizational culture and leadership commitment to transparency and collaboration, along with tailoring information-sharing strategies to specific supply chain contexts, is essential for enhancing supply chain resilience. This research contributes to the understanding of the impact of information sharing on supply chain resilience and provides practical insights for organizations aiming to strengthen their resilience in an increasingly complex global business environment.

The study investigates the influence of power dynamics on supply chain decision-making processes through a qualitative lens, aiming to understand how various forms of power impact interactions, relationships, and strategic outcomes within supply chains. Using semi-structured interviews with supply chain managers and executives from diverse industries, the research explores the multifaceted nature of power, identifying key sources such as economic leverage, expertise, resource control, and network centrality. Findings reveal that power dynamics significantly shape decision-making by determining negotiation outcomes, governance structures, and operational efficiencies. Economic power, often exercised by larger firms, enables them to dominate negotiations and impose favorable terms, creating pressures on smaller partners and potentially leading to conflicts. Expertise and resource control allow firms with specialized knowledge or unique inputs to influence product development and process innovation, further dictating supply chain configurations. The study differentiates between coercive and non-coercive power strategies, showing that while coercive power enforces compliance, it can erode trust and collaboration. Non-coercive power, on the other hand, promotes positive relationships through incentives and collaborative approaches, fostering trust and alignment of supply chain objectives. Governance structures imposed by dominant firms often reflect their strategic priorities but can burden less powerful partners, highlighting the need for balanced oversight. Power also plays a crucial role in risk management, resilience, sustainability, and innovation within supply chains, with digitalization introducing new dimensions of influence. The research underscores the importance of balanced and equitable power dynamics to enhance cooperation, resilience, and innovation in supply chains. These insights provide valuable implications for practitioners and scholars in developing more effective and adaptive supply chain strategies.

This qualitative study explores sustainable procurement practices and supplier selection criteria, delving into the complexities, challenges, and opportunities of integrating sustainability considerations into procurement decisions. Through in-depth interviews with procurement professionals from diverse industries, the research uncovers key themes such as the multifaceted nature of sustainable procurement criteria, the challenge of assessing and managing suppliers' sustainability performance, the importance of collaboration and communication, and the influence of regulatory and market pressures. Findings reveal that sustainable procurement involves a comprehensive approach that considers environmental, social, and ethical factors alongside traditional criteria like cost and quality. Assessing suppliers' sustainability performance emerges as a significant challenge, necessitating robust assessment processes and technological solutions to enhance transparency and traceability. Collaboration and communication with suppliers are identified as critical enablers of sustainable procurement, fostering trust and mutual understanding. Regulatory mandates and market demands drive organizational commitments to sustainability, shaping supplier selection criteria and procurement strategies. Despite challenges, sustainable procurement offers benefits such as enhanced risk management, cost savings, innovation, and reputation enhancement. Overall, sustainable procurement represents a strategic approach that contributes to positive environmental and social outcomes, supporting a more sustainable and equitable future for organizations and society.

This study investigates the pivotal role of leadership in driving sustainable supply chain initiatives (SSCI), highlighting the multifaceted ways through which leaders influence the successful integration and implementation of sustainability practices within supply chains. Using a qualitative approach, the research involved semi-structured interviews with leaders and managers from diverse industries, complemented by document analysis and thematic analysis to capture the complexities of leadership in SSCI. The findings reveal that visionary leadership, characterized by a clear and compelling sustainability vision, plays a crucial role in aligning organizational goals with sustainable practices, inspiring collective action, and fostering a shared commitment to long-term environmental and social objectives. Stakeholder engagement emerged as a critical factor, with leaders who prioritize open communication and collaboration successfully building trust, leveraging expertise, and co-creating innovative solutions to sustainability challenges. Additionally, the study highlights the importance of fostering a culture of innovation, where leaders support experimentation, risk-taking, and the adoption of new technologies and processes that enhance sustainability. Ethical leadership, emphasizing integrity, transparency, and accountability, is identified as essential for gaining stakeholder support and reinforcing the legitimacy of SSCI. Furthermore, the integration of sustainability into organizational culture, driven by leadership, is crucial for aligning individual and organizational behaviors with sustainability goals. The ability of leaders to navigate challenges, adapt to global supply chain complexities, and utilize robust sustainability metrics is also emphasized as key to sustaining SSCI. The study concludes that effective leadership is integral to the success of SSCI, offering valuable insights for organizations aiming to enhance their sustainability performance and contributing to the broader understanding of leadership’s role in sustainable supply chain management.

This ethnographic study investigates the cross-cultural challenges encountered in global supply chains, focusing on communication barriers, diverse business practices, trust-building, ethical and legal standards, and cultural competence. By embedding within the day-to-day operations of multinational corporations and conducting in-depth interviews with supply chain professionals, the research provides a nuanced understanding of the cultural dynamics that impact global supply chain management. The findings highlight that effective communication goes beyond language proficiency, requiring an understanding of varying communication styles and contextual nuances. Business practices shaped by cultural values such as power distance and uncertainty avoidance necessitate adaptive management strategies that balance local norms with global standards. Trust and relationship-building are critical, particularly in cultures where personal relationships underpin business transactions, demanding long-term investment in relationship-building activities. Ethical and legal standards vary significantly across regions, presenting challenges that require a nuanced approach to global governance. The study underscores the importance of cultural competence as a critical skill for supply chain professionals, enabling them to bridge cultural gaps and foster productive collaborations. Sustainability efforts, entrepreneurship, and innovation are also influenced by cultural factors, highlighting the need for culturally sensitive strategies. Emotional intelligence is identified as essential for managing cross-cultural interactions, with participants demonstrating high emotional intelligence more effectively navigating the emotional and social complexities of cross-cultural communication. The use of technology in managing cross-cultural challenges is acknowledged, but the findings suggest that it must be complemented by cultural competence. Overall, the study provides valuable insights for companies seeking to enhance their cross-cultural effectiveness, emphasizing the importance of cultural competence, communication, and relationship-building in achieving sustainable success in global supply chains.

This qualitative research study delves into the intricate dynamics of how organizations adapt to supply chain disruptions during crises, offering profound insights into the strategies, practices, and challenges encountered in enhancing supply chain agility. Through in-depth interviews with supply chain managers across diverse industries, key themes such as proactive risk management, technological integration, collaboration with supply chain partners, and adaptive leadership have emerged as crucial determinants of agility and resilience. Additionally, the study highlights the significance of organizational culture, effective communication, and external factors such as regulatory requirements and market dynamics in shaping supply chain agility. By embracing a holistic approach that integrates these multifaceted factors, organizations can bolster their capacity to anticipate, detect, and respond to disruptions, thereby maintaining or enhancing overall performance even in the face of uncertainty and complexity. The insights gleaned from this research are poised to inform theory development, guide managerial practice, and influence policy-making in the realm of supply chain management, equipping organizations with the knowledge and tools needed to navigate future disruptions successfully.

This qualitative research study explores the multifaceted impacts of digital transformation on supply chain processes within contemporary business environments. Through in-depth interviews with industry professionals, the study investigates the implications of digitalization for visibility, collaboration, resilience, and innovation within supply chains. The findings highlight the opportunities presented by digital technologies for enhancing operational efficiency, mitigating risks, and creating value across supply chain networks. However, the study also underscores the challenges and barriers that organizations face in their digital transformation journey, including integration complexity, data security, and organizational culture. The research emphasizes the importance of strategic investments in digital capabilities, change management, and organizational culture to capitalize on the opportunities presented by digital transformation while addressing the associated challenges. By doing so, organizations can build agile, resilient, and competitive supply chains capable of thriving in an increasingly digitalized and interconnected world.

In today's globalized business environment, multinational corporations (MNCs) face significant challenges in achieving and sustaining effective supply chain integration across diverse cultural contexts. This qualitative research explores the influence of cultural factors on supply chain integration within MNCs, employing in-depth interviews and thematic analysis to uncover key insights. Findings reveal the complex interplay between culture and supply chain practices, highlighting challenges related to cross-cultural communication, trust-building, decision-making, and organizational culture alignment. However, the study also identifies opportunities for leveraging cultural diversity as a source of competitive advantage, emphasizing the importance of cultural intelligence and cross-cultural competence for supply chain professionals. The implications of the research extend to managerial practice, suggesting the development of culturally sensitive strategies for supply chain integration and investment in cultural training and development programs. Moreover, the study underscores the need for a holistic approach to supply chain integration that considers not only technical and operational aspects but also cultural and social dimensions. While the research offers valuable insights, limitations such as the qualitative nature of the study and the focus on supply chain managers' perspectives should be considered. Future research could address these limitations and explore the interdependencies among various contextual factors to enhance our understanding of cultural influences on supply chain integration in MNCs.

Ethical sourcing practices play a pivotal role in addressing price inflation within renewable energy supply chains. This qualitative research investigates the multifaceted impacts of ethical sourcing, drawing insights from interviews with key stakeholders in the renewable energy sector. The study reveals that ethical sourcing enhances supply chain transparency, traceability, and resilience by mitigating risks associated with unethical practices such as labor exploitation and environmental degradation. Fair trade initiatives contribute to economic stability and reduce price volatility by ensuring fair compensation for producers and workers, fostering long-term relationships, and reinvesting premiums into community development projects. Sustainable sourcing practices align with consumer preferences for eco-friendly products, reduce the demand for virgin resources, and promote regulatory compliance and incentives, thereby stabilizing costs and reducing environmental impact. Socially responsible companies that prioritize fair labor practices and community support experience fewer disruptions and benefit from a more stable and productive workforce. Entrepreneurship and emotional intelligence among leaders drive the adoption and successful implementation of ethical sourcing practices, enhancing brand reputation, consumer trust, and market competitiveness. Despite challenges, such as higher implementation costs and supplier resistance, the long-term benefits of ethical sourcing outweigh the initial costs and contribute to sustainable supply chains. Collaboration, consumer education, and effective regulation are essential for promoting ethical sourcing across the renewable energy sector.

This qualitative research explores the influence of Corporate Social Responsibility (CSR) on supply chain sustainability within the renewable energy sector. Through a comprehensive review of existing literature, key themes and patterns are identified, shedding light on the complex dynamics and interrelationships inherent in CSR practices and their impact on supply chain sustainability. The findings highlight the critical role of CSR in driving environmental sustainability, social equity, economic viability, governance mechanisms, and technological innovation across renewable energy supply chains. Environmental sustainability emerges as a priority, with CSR initiatives focusing on reducing carbon emissions, promoting clean energy technologies, and adopting sustainable sourcing strategies. Social equity is emphasized through stakeholder consultation, transparent decision-making, and investments in community development. Economic viability is addressed through considerations of brand reputation, financial performance, and regulatory compliance. Governance mechanisms and regulatory frameworks play a crucial role in shaping CSR practices, with collaborative partnerships and policy advocacy driving industry-wide change. Technological innovation, particularly the integration of blockchain, IoT, and AI, enhances transparency, traceability, and accountability in supply chains. The study concludes by discussing theoretical implications, practical insights, limitations, and avenues for future research, highlighting the importance of CSR in promoting sustainable development in the renewable energy sector.

The renewable energy sector plays a pivotal role in addressing climate change and achieving sustainable development goals. However, the sector faces challenges related to price inflation and supply chain disruptions, which can impede its growth and resilience. This qualitative research explores supply chain resilience strategies adopted by companies in the renewable energy sector to mitigate the impact of price inflation and disruptions. Through semi-structured interviews with key industry stakeholders, the study identifies several key themes. Supplier diversification emerges as a crucial strategy for mitigating risks associated with geopolitical tensions and trade restrictions. Inventory management plays a pivotal role in ensuring continuity in operations amidst supply chain disruptions, with a focus on optimizing inventory levels of critical components. The adoption of digital technologies offers significant potential for enhancing supply chain visibility, transparency, and responsiveness, although integration challenges remain. Collaboration and partnerships within the industry are essential for sharing resources, knowledge, and best practices, fostering innovation and collective problem-solving. Sustainable practices are integral to supply chain resilience, aligning with broader industry trends towards environmental stewardship and social responsibility. Overall, the findings highlight the multifaceted nature of supply chain resilience in the renewable energy sector and the interconnectedness of various strategies and practices. Moving forward, companies must adopt a proactive and adaptive approach to supply chain management, integrating these strategies and practices into their operations to navigate uncertainties and drive sustainable growth. This study contributes to the understanding of supply chain resilience in the renewable energy sector and provides valuable insights for industry stakeholders, policymakers, and researchers.

This study focuses on the impact of collaboration on reducing price inflation in renewable energy supply chains. The study utilises in-depth interviews and theme analysis to reveal the complex dynamics of collaboration among stakeholders and the resulting implications for addressing difficulties in the renewable energy sector. Trust is a key factor in successful collaboration, whereas legal frameworks and policy incentives are important in influencing collaborative activities. Collaborative procurement, cooperative research and development, strategic alliances, and collaborative supply chain management are recognised as crucial measures for decreasing expenses, promoting innovation, and improving resilience in renewable energy supply chains. Nevertheless, in order to achieve successful collaboration, it is necessary to overcome obstacles such as lack of trust, uncertainty in regulations, and competitive dynamics. Creating a cooperative environment that prioritises common objectives, openness, and reciprocal advantages is crucial for fully harnessing the potential of renewable energy supply chains in promoting sustainable energy transitions. The report provides practical insights and recommendations for policymakers, industry professionals, and academics who aim to encourage collaboration and reduce price inflation in renewable energy supply chains.

This qualitative research investigates the effectiveness of certification programs in ensuring supply chain sustainability within the renewable energy sector. Through interviews and content analysis, the study explores stakeholder perceptions, challenges, and impacts of certification initiatives. Findings reveal diverse motivations driving certification adoption, including regulatory compliance, market differentiation, and corporate social responsibility. However, challenges such as greenwashing and limited transparency undermine the credibility and effectiveness of certification programs. Despite these challenges, certification initiatives drive incremental improvements in environmental performance and stakeholder engagement, fostering a culture of continuous improvement and innovation. Multi-stakeholder collaboration and context-specific approaches are essential to address regional disparities and promote sector-wide transformation. Strategies for improvement include strengthening monitoring and enforcement mechanisms, integrating emerging technologies, and aligning certification standards with broader sustainability goals. Overall, certification programs offer a pathway for promoting transparency, accountability, and responsible business practices within the renewable energy supply chain, contributing to the transition towards a more sustainable and resilient energy future.

This qualitative research investigates the intricate relationship between market dynamics and supply chain sustainability in the renewable energy sector. Amidst the global energy transition, renewable energy has emerged as a crucial player in mitigating climate change and fostering sustainable development. However, ensuring the sustainability of renewable energy supply chains presents complex challenges shaped by various market forces. Through semi-structured interviews and thematic analysis, this study explores how policy frameworks, technological innovation, market competition, consumer preferences, and investor demands influence sustainability practices across the renewable energy supply chain. The findings highlight the critical role of supportive policy environments, technological advancements, and stakeholder collaboration in driving sustainability performance and mitigating risks within renewable energy supply chains. Furthermore, the study identifies challenges such as supply chain complexity, regulatory compliance, and stakeholder engagement, underscoring the need for collaborative efforts and multi-stakeholder partnerships. By addressing these challenges and leveraging opportunities, stakeholders can advance sustainability goals, mitigate climate change impacts, and foster a more resilient and equitable renewable energy sector. The research contributes to a deeper understanding of market dynamics and supply chain sustainability in the renewable energy sector, offering insights for policymakers, industry stakeholders, and sustainability practitioners to inform evidence-based decision-making and drive positive change.

In sustainable floriculture, the integration of arbuscular mycorrhizal fungi (AMF) and salicylic acid (SA) in the cultivation of statice flowers presents a promising ecofriendly approach to enhancing crop health and productivity. AMF improve nutrient uptake, particularly phosphorus, in plants, leading to stronger growth and abundant flowering while reducing the reliance on chemical fertilizers. Additionally, AMF enhance soil structure and water retention, fostering robust root systems and increasing the plant's resilience to drought and soil-borne pathogens thus improving soil health and minimizing environmental impact. Complementarily, the application of salicylic acid boosts the plant’s innate defense mechanisms, elevating its resistance to diseases, enhancing stress tolerance, helping statice flowers withstand adverse conditions such as drought and salinity, and promotes vigorous root development for better nutrient absorption. Hence, this study evaluates the effect of mycorrhizal inoculation and salicylic acid treatment on ornamental statice (Limonium sinuatum [L.] Mill.) cv. Qis White. The investigation involves two primary factors: mycorrhizal inoculation and salicylic acid concentration. For mycorrhizal inoculation, the study compares the untreated control with treatments including Glomus mossae, Gigaspora margarita, and a mixture of both fungi (applied as basal during transplanting). For salicylic acid, the study assesses the untreated control alongside treatments with Salicylic Acid at 100 mg L-1, 150 mg L-1, and 200 mg L-1 (applied as foliar spray at 45 and 90 days after transplanting) in a factorial RCBD experiment with three replications. Growth, flowering, yield and biomass parameters were assessed in this study. The results indicated that statice plants benefited from mycorrhizal inoculation, particularly with Glomus mosseae, when paired with salicylic acid @ 200 mg L-1. This was further validated by principal component analysis. AMF inoculated plants showed improved growth, and superior flower qualities compared to non-inoculated plants. Additionally, the application of salicylic acid demonstrated positive effects across various parameters. Notably mycorrhization led to a delay of 4 to 9 days in the flowering time of statice. In conclusion, mycorrhizal inoculation and salicylic acid can enhance the growth and flowering attributes of statice by choosing the appropriate mycorrhizal inoculum and optimal salicylic acid concentrations. In the future they can contribute to more sustainable and productive statice cultivation by reducing the need for chemical inputs and supporting overall plant health.

This review critically assesses the body of research about Measles-Mumps-and-Rubella (MMR) vaccine attitudes and uptake in the United Kingdom (UK) over the past 10 years. We searched PubMed and Scopus, with terms aimed at capturing relevant literature on attitudes, uptake, decision-making, and beliefs about the MMR vaccine. Two researchers screened for abstract eligibility and after de-duplication 934 studies were selected. After screening, 40 references were included for full-text review and thematic synthesis by three researchers. We were interested in the methodologies employed, and grouped findings by whether studies concerned: (1) Uptake and Demographics; (2) Beliefs and Attitudes; (3) Healthcare Worker Focus; (4) Experimental and Psychometric Intervention; (5) Mixed Methods. We identified group and individual level determinants for attitudes, operating directly and indirectly, that influence vaccine uptake. We found that access issues, often ignored within the public “anti-vax” debate, remain highly pertinent. Finally, a consistent theme was the effect of misinformation and lack of knowledge or trust in healthcare, often stemming from the Wakefield controversy. Future COVID-19 immunisation campaigns for children should consider both access and attitudinal aspects of vaccination, and incorporate a range of methodologies to assess progress, taking into account socio-economic variables and the needs of disadvantaged groups.

The study aimed to investigate the effect of climate change exposure on affect and pro-environmental behavioural intentions in a randomised controlled trial. An online survey was completed by 100 adult participants and included measures of affect and pro-environmental behavioural intentions pre- and post-exposure. Participants were randomly allocated to a group that saw a climate change video (n=55) or a group that saw a non-climate change video (n=45). The findings showed were that participants in the climate change group showed a significant increase in negative affect and pro-environmental behavioural intention scores post-video exposure compared to the non-climate change video group. This suggests that climate change video exposure negatively influences affect but also potentially increases the intention to act pro-environmentally. These findings have the potential to support policies and societal change, however further investigation into the type of contents, actual behaviour change, and impacts on diverse populations (e.g., minority groups) is needed that influences pro-environmental behaviours is required. Furthermore, to achieve a greater impact, future research should be conducted measuring actual pro-environmental behaviour change, including with those from diverse populations.

Households and businesses are generating unprecedented levels of electrical and electronic wastes (e-waste), fueled by modernisation and rapid obsolescence. While the challenges imposed by e-waste are similar everywhere in the world, disparities in progress to deal with it exists; with developing nations such as South Africa lagging. The increase in e-waste generation increases the need to formulate strategies to manage it. This paper presents an overview of e-waste management on a global and South African scenarios with a specific case for Cathode Ray Tube (CRT) waste management practices in South Africa. CRTs present the biggest problem for recyclers and policy makers because they contain hazardous elements such as lead and antimony. Common disposal practices have been either landfilling or incineration. The research into the South African practices with regards to CRT waste management showed that there is still more to be done to effectively manage this waste stream. This is despite clear waste regulatory frameworks in the country. However, recent developments have placed e-waste as a priority waste stream, which should lead to intensified efforts in dealing with it. Overall, these efforts should aim to maximise diversion from landfilling and to create value-addition opportunities, leading to social and environmental benefits.

From single-cell organisms to complex neural networks, all evolved to provide control solutions to generate context and goal-specific actions. Neural circuits performing sensorimotor computation to drive navigation employ inhibitory control as a gating mechanism, as they hierarchically transform (multi)sensory information into motor actions. Here, we focus on this literature to critically discuss the proposition that prominent inhibitory projections form sensorimotor circuits. After reviewing the neural circuits of navigation across various invertebrate species, we argue that with increased neural circuit complexity and the emergence of parallel computations inhibitory circuits acquire new functions. The contribution of inhibitory neurotransmission for navigation goes beyond shaping the communication that drives motor neurons, instead, include encoding of emergent sensorimotor representations. A mechanistic understanding of the neural circuits performing sensorimotor computations in invertebrates will unravel the minimum circuit requirements driving adaptive navigation.

The development of biofuels and biodiesel industry specifically, has resulted in the generation of large amounts of glycerol as a surplus. The conversion of glycerol, into chemicals with indus-trial interest, through anaerobic fermentation using E. coli as a biocatalyst is an attractive alter-native to improve economic performance in the biodiesel industry, for example through the bi-otransformation of residual glycerol into ethanol. For 2019, the size of the global ethanol market was valued at $ 89.1 billion US dollar. Biodiesel can be produced from several materials like rapeseed, palm, soya, corn, palm kernel, frying oil or olive-pomace oil (OPO). The last, can be extracted from alperujo, byproduct of olive oil process. However, olive-pomace oil converting into biodiesel is not enough established to achieve a global olive-oil/biodiesel derived process with minimized waste generation. Traditionally biodiesel production process produces an equivalent of 10% by mass of glycerol as a waste or by-product. This work explores the conver-sion of residual glycerol into chemicals like ethanol and hydrogen with a focus on projecting raw material potential availability from OPO, contributing to the promotion of the use of biofu-els and biodegradable compounds.

Indoor comfort is a critical determinant of the holistic educational experience, significantly influencing the well-being, concentration, and performance of students within the confines of school environments. Despite the widespread implementation of heating, ventilation, and air conditioning (HVAC) systems in educational institutions, achieving satisfactory thermal conditions, acceptable acoustics, and optimal daylight levels for occupants continues to pose a considerable challenge. In this review, we specifically delves into the parameters characterizing Italian school environments, recognizing their direct impact on students’learning and concentration. The primary objectives of this review are conducting a thorough examination of the current acustic conditions in Italian schools. The initial phase of our search strategy involved retrieving data from key databases, namely, Scopus, Web of Science, ScienceDirect, PubMed, and Google Scholar. Following the elimination of duplicate articles (n = 289), a total of 135 distinct papers remained for analysis. A critical review of the existing literature is presented based on these criteria, offering guidelines and recommendations for forthcoming studies. The critical review underscores various shortcomings in the current design, deployment, and documentation of multi-domain studies, signaling the need for enhanced quality in future research efforts.

Extensive use of petrochemical plastic packaging leads to the greenhouse gas emission and con-tamination to soil and oceans, posing major threats to the ecosystem. The packaging needs, hence, are shifting to bioplastics with natural biodegradability. Lignocellulose, the biomass from forest and agriculture, can produce cellulose nanofibrils (CNF), a biodegradable material with ac-ceptable functional properties, that can make packaging among other products. CNF extracted from lignocellulosic wastes can lower the packaging carbon footprint and the production cost. Most of these low value feedstocks go to alternative applications, that make their use in CNF packaging competitive. To transfer the waste materials from current practices to the packaging production, it is imperative to assess their sustainability, encompassing environmental and eco-nomic impacts along with the feedstock physical and chemical properties. A consolidated over-view of these criteria is absent in the literature. This study performs an iterative literature review and presents thirteen attributes, delineating sustainability of lignocellulosic wastes for commer-cial CNF packaging production. These criteria data are gathered for the UK waste streams, and transformed into a quantitative matrix, evaluating the waste feedstock sustainability for CNF packaging production. The presented approach can be adopted to decision scenarios in bioplas-tics packaging conversion and waste management.

Recent studies have demonstrated silk fibroin’s ability to extend the shelf life of foods by mitigating the hallmarks of spoilage, namely oxidation and dehydration. Due to the potential for this protein to become more widespread, its safety was evaluated comprehensively. First, a bacterial reverse mutation test (Ames test) was conducted in five bacterial strains. Second, an in vivo erythrocyte test was conducted with Sprague Dawley rats at doses up to 1,000mg/kg-bw/day. Third, a range-finder study was conducted with Sprague Dawley rats at the highest consumption amount given solubility and oral gavage volume constrains (500mg/kg-bw/day). Fourth, a 28-day study in Sprague Dawley rats was conducted at the 500mg/kg-bw/day amount. Fifth, an in vitro pepsin digestion assay was performed to assess the potential for protein allergenicity. Sixth, allergenic potential was further assessed using liquid chromatography-mass spectroscopy for detection of allergenic insect proteins. Seventh, the protein sequences were subjected to bioinformatic analyses. Together, these studies raise no mutagenic, carcinogenic, toxicological, or allergenic concerns with the oral consumption of silk fibroin.

Background: This study aims to investigate the patient safety culture at a sports medicine hospital and explore quality of healthcare and associated factors. Methods: In a cross-sectional study design, the tool Hospital Survey on Patient Safety Culture (HSOPC) was administered online among staff at a sports medicine hospital in Doha, Qatar. About 319 staff participated from 898 staff who received emails (35.5%). Results: The results showed that 49.2% of the staff rated the patient safety grade as excellent and 36.1% as very good, which sums up to 85.3%. Factors associated with better patient safety grade were work climate (OR 10.3 95% CI (3.2 to 33.6); teamwork OR 7.6 95% CI (2.8 to 20.9) and team communication (OR 2.9 95% CI (1.1 to 7.6). Conclusions: Addressing the work climate, enhancing communication, and cohesive work within teams facilitates a culture of trust that improves patient safety grade. Ensuring quick return to play is a team effort involving multiple disciplines, hence a high performance and safety culture can enhance teamwork. Reducing punitive response to error and encouraging staff and supervisors are key areas that can improve safety culture in sports medicine organizations, and efforts should be placed in this area.

In forensic acoustics, a possible area of analysis is represented by unwanted sound that 1 is perceived as a source of intrusion or disturbance within a certain auditory context. This context 2 is defined as the "auditory scene" and refers to the set of sounds present in a specific environment. 3 The presence of unwanted sounds in the auditory scene can cause a wide range of negative effects, 4 including disturbance, discomfort, moral or immoral harm, and other types of negative impact on the 5 health and well-being of individuals exposed to noise. In 2022, the technical specification UNI/TS 6 11844:2022 dedicated to the measurement and analysis of intrusive noise was published. The standard 7 introduces the concept of intrusive noise and defines its calculation methods based on environmental 8 measurements. The purposes of this technical specification is to provide an objective support to 9 methods already in used in acoustic disputes, where the assessment of the annoyance of a noise is 10 often a subjective evaluation of the technician. This work delves into the application to some real 11 cases, identifying the potentiality and the limits of the standardized method.

Protein tyrosine phosphatase receptor type E (PTPRE) is a member of the “classical” protein tyrosine phosphatase subfamily and regulates a variety of cellular processes in a tissue-specific manner by antagonizing the function of protein tyrosine kinases. PTPRE plays a tumorigenic role in different human cancer cells, but its role in retinoblastoma (RB), the most common malignant eye cancer in children, remains to be elucidated. Etoposide resistant RB cell lines and RB patients display significant higher PTPRE expression levels compared to chemosensitive counterparts and the healthy human retina, respectively. PTPRE promotor methylation analyses revealed that PTPRE expression in RB is not regulated via this mechanism. Lentiviral PTPRE knockdown (KD) induced a significant decrease in growth kinetics, cell viability, and anchorage independent growth of etoposide resistant Y79 and WERI RB cells. Caspase-dependent apoptosis rates were significantly increased and a re-sensitization for etoposide could be observed after PTPRE depletion. In vivo chicken chorioallantoic membrane (CAM) assays revealed decreased tumor formation capacity as well as reduced tumor size and weight following PTPRE KD. Expression levels of miR631 were significantly downregulated in etoposide resistant RB cells and patients. Transient miR631 overexpression resulted in significantly decreased PTPRE levels and concomitantly decreased proliferation and increased apoptosis levels in etoposide resistant RB cells, impacts mirroring PTPRE KD effects and indicating PTPRE regulation via this miR. Additionally, PTPRE KD led to altered phosphorylation of protein kinase SGK3 and - dependent on the cell line - also AKT and ERK1/2, suggesting potential PTPRE downstream signaling pathways. In summary, these results indicate an oncogenic role of PTPRE in chemoresistant retinoblastoma.

Since December 2019, the coronavirus disease (COVID-19) has rapidly spread worldwide. The Mexican government has implemented public safety measures to minimize the spread of the virus. In this paper, the authors use statistical models in two stages to estimate the total number of coronavirus (COVID-19) cases per day at the state and national level in Mexico. Two types of models are proposed: first, a polynomial model of the growth for the first part of the outbreak until the inflection point of the pandemic curve and then a second nonlinear growth model is used to estimate the middle and the end of the outbreak. Model selection will be performed using Vuong’s test. The proposed models show overall fit similar to predictive models (e.g. time series, and machine learning); however, the interpretation of parameters is less complex for decision-makers and the residuals follow the expected distribution when fitting the models without autocorrelation being an issue.

The purpose of this study was to identify potential causes of violence and crime in informal settlements and residents’ strategies for response and prevention to these issues, as perceived by women living in Mathare informal settlement in Nairobi, Kenya. A total of 55 in-depth interviews were conducted with women living in the informal settlement in 2015-2016. A modified grounded theory approach was used to guide data collection and analysis. The most common contributor to violence and crime identified by women in Mathare informal settlement was idle youth, but leadership and government challenges, corruption and/or inadequacy of police, community barriers, tribalism, and lack of protective infrastructure also emerged as contributing factors. Despite facing many economic, environmental, and day-to-day challenges, women in Mathare identified violence and crime as predominant issues; thus, developing effective response and prevention strategies to these issues in informal settlements is paramount. Women suggest there are many strategies and initiatives to reduce and prevent violence and crime in informal settlements, but also identified barriers to implementing them. Findings suggest there is a need for trust-building between formal and informal organizations and institutions, systems of accountability, and long-term investment to foster sustainable and effective violence and crime response and interventions in these settlements.

The quality of wine depends upon the quality of the grapes, which, in turn, are affected by different viticulture aspects and the climate during the grape-growing season. Obtaining wine professionals’ judgments of the intrinsic qualities of selected wine products is a time-consuming task. It is also expensive. Instead of waiting for the wine to be produced, it is better to have an idea of the quality before harvesting, so that wine growers and wine manufacturers can use high-quality grapes. The main aim of the present study was to investigate the use of machine learning aspects in predicting wine quality and to develop a pipeline which represents the major steps from vineyards to wine quality indices. This pipeline outputs the predicted yield, values for basic parameters of grape juice composition, values for basic parameters of the wine composition, and quality. We also found that the yield could be predicted because of input data related to the characteristics of the vineyards. Finally, through the creation of a web-based application, we have investigated the balance berry yield and wine quality. Using these tools further developed, vineyard owners should be able to predict the quality of the wine they intend to produce from their vineyards before the grapes are even harvested.

Acute pancreatitis (AP) is an inflammatory condition of the pancreas and is one of the most common ailments of the gastrointestinal system that results in significant morbidity and mortality. The main etiologic causes of AP are alcohol consumption, gallstones, hypertriglyceridemia, and biliary stones. The clinical signs and symptoms, and diagnostic criteria of AP are well established in the literature and multiple studies. Multiple scoring systems have been used to predict the severity, prognosis, and mortality associated with AP. The present review of the literature brings to light the significant and recent contributions in the etiology, risk factors, epidemiology, diagnosis, complications, prognosis and newest modalities in treatment that could be beneficial in the management of AP.

Oncogenic protein E6 from Human Papilloma Virus 16 (HPV-16) mediates the degradation of Membrane-associated guanylate kinase with inverted domain structure-1 (MAGI-1), throughout the interaction of its protein binding motif (PBM) with the Discs-large homologous regions 1 (PDZ1) domain of MAG1-1. Generic variation in the E6 gene that translates to changes in the protein’s amino acidic sequence modifies the interaction of E6 with the cellular protein MAGI-1. MAGI-1 is a scaffolding protein found at tight junctions of epithelial cells, where it interacts with a variety of proteins regulating signaling pathways. MAGI-1 is a multidomain protein containing two WW (rsp-domain-9), one guanylate kinase-like, and six PDZ domains. PDZ domains played an important role in the function of MAGI-1 and served as targets for several viral proteins including the HPV-16 E6. The aim of this work was to evaluate, with an in silico approach, employing molecular dynamics simulation and protein-protein docking, the interaction of the intragenic variants E-G350 (L83V), E-C188/G350 (E29Q/L83V), E-A176/G350 (D25N/L83V), E6-AAa (Q14H/H78Y/83V) y E6-AAc (Q14H/I27RH78Y/L83V) and E6-reference of HPV-16 with MAGI-1. We found that variants E-G350, E-C188/G350, E-A176/G350, AAa and AAc increase their affinity to our two models of MAGI-1 compared to E6-reference.

In recent years, the need to make the built environment more resilient and adaptable to climate change has become increasingly evident. In Europe, this aspect concerns the vast majority of existing buildings, which present several deficiencies from the energy-efficiency point of view, considering they were designed before the introduction of modern energy codes. Nowadays, it is possible to retrofit existing buildings using advanced and high-efficient technologies such as Double Skin Façades (DSFs). The research aims to evaluate the use of properly designed DSFs for the energy restoration of existing buildings. In detail, various DSF configurations are applied to a residential building located in central Italy and investigated under present and future climate conditions, estimated through regional climate models. The results underline that all the analysed Double Skin Façades confirm to be a useful option, and, in particular, the Multi-Storey typology allows drastic energy needs decrement. Moreover, the general increase in temperatures and solar radiations could affect the building energy performance, and the insertion of DSF can mitigate the climate change effects, reducing the predicted energy consumption and ensuring better behaviours than the building in its original state.

The scratch test consists in pushing a tool across the surface of a material at a given penetration depth or applied load. It has several applications in Science and Engineering including strength testing, damage and quality control of thin films and coatings. Despite numerous attempts in scientific literature, the application of scratch test to characterizations of fracture properties remains a heavily controversial topic. Therefore, this investigation arises as an experimental study in order to assess the fracture toughness using scratch test. A study on the effect of cryogenic treatment, performed after tempering, on fracture toughness, via scratch test experiments, of different tool steels has been made. A laboratory investigation on AISI D2, AISI M2 and X105CrCoMo18 steel confirms the possibility of increasing the fracture toughness by carrying out the cryogenic treatment after the usual heat treatment

The graphene based highly conductive and flexible devices has received momentous attraction and growth in recent years for potential multifunctional uses. The development of flexible and washable textile sensors, actuators, energy storage and energy harvesting systems. Textile fabrics coated with graphene and conductive polymers have been used for wearable self-powered e-textiles, such as tribo-electric, piezoelectric, and Thermoelectric. Herein this research, 100% woven cotton fabric is Fictionalized with graphene oxide (GO) using industrial-scale cold pad batch dyeing technique for the development of low-grade body heat into self-powered wearable e-textiles. The conductive polymer PEDOT: PSS was coated using layer by layer approach. The study demonstrates that the resultant textile electrodes showed reduced electrical sheet resistance from 2.5 MΩ to 15KΩ, with a reduced graphene oxide and further reduced to (2.5 -12.5 Ω) for conductive polymer. The sheet resistance was decreased with the number of dyeing cycles (10-15) and increased with 20 washing cycles vice versa. The study demonstrates that the sensor response and performance were improved with increasing the content percent of rGO and PEDOT: PSS. The tensile strength of as coated fabric electrodes was improved from (25.0-85.5 mPa) and fabric thickness was increased to (26-38µm) without compromising or influencing the air permeability. The resultant textile electrodes may potentially be used in smart textiles for self-powered flexible wearable generators, sensors, and energy storage. The study demonstrates that the cold pad batch dyeing method is a suitable and effective method for the fabrication of graphene-based textiles.

In 2020, students of Pakistan had to adapt to the online environment for the very first time. This study aims to analyze the perceptions of medical, dental, and allied health students about online education in Pakistan. A descriptive, cross-sectional study was done to assess the level of acceptance of undergraduate students. A pre-validated questionnaire regarding demographics, past-experience of e-learning, advantages disadvantages of e-learning, and general perception of students towards e-learning was distributed. Descriptive statistics were computed for demographics, Mann-Witney-U test was used to compare the differences of perceptions between pre-clinical year and clinical years students. Kruskal-Wallis test was applied to compare the results of three specialties of students. Chi-square was used to compare overall category-wise positive and negative responses of students. 1200 students participated in the study. The major advantage identified by all students was the ‘comfortable environment’ in which they studied online. The major disadvantage selected by preclinical year students was ‘anxiety due to social isolation’ and that chosen by clinical year students was ‘lack of patient interaction’. Overall, 72% of students had a negative perception of e-learning. Student-teacher training, student counselling sessions, and innovative techniques need to be introduced to enhance student engagement and reduce pandemic stress.

As air traffic demand grows, robust, data-driven anomaly detection methods are required to ensure that aviation systems become safer and more efficient. The terminal airspace is identified as the most critical airspace for both individual flight-level and system-level safety and efficiency. As such, developing data-driven anomaly detection methods to analyze terminal airspace operations is paramount. With the expansion of ADS-B technology, open-source flight tracking data has become more readily available to enable larger-scale analyses of aircraft operations. This paper makes a distinction between spatial metrics in ADS-B trajectory data and energy metrics derived from ADS-B trajectory data. Motivated by the limited number of approaches that simultaneously consider both spatial and energy metrics, this paper introduces the concepts of spatial anomalies and energy anomalies. In particular, it proposes a novel, unified framework for detection of spatial and energy anomalies in ADS-B trajectory data (and associated derived metrics). The framework consists of three main parts - a data processing procedure, a spatial anomaly detection method, and an energy anomaly detection method. The framework is demonstrated utilizing four months of ADS-B trajectory data associated with arrivals at San Francisco International Airport, and the relationship between the spatial and energy anomalies in this terminal airspace is explored. The results that stem from the implementation of this framework indicate that if an aircraft is spatially not conforming to an identified set of air traffic flows representing standard spatial operations, then this aircraft is more likely to experience non-conformance to standard operations in its energy metrics. Aviation operators, such as air traffic controllers, may benefit from this observation, as it may factor into decision-making in instances where there is the potential to instruct an aircraft to spatially deviate from standard operations. Additionally, this research revealed underlying differences between trajectories that are spatially nominal yet energy-anomalous and those trajectories that are spatially anomalous and energy-anomalous. Focusing solely on energy anomaly detection does not provide insight into potential spatial-related decisions that may have been made to result in off-nominal energy behavior.

Non-invasive continuous health monitoring has become feasible with the advancement of biosensors. While monitoring certain biomarkers such as heart rate or skin temperature are now at certain maturity, monitoring molecular biomarkers is still challenging. Progress has been shown in sampling, measurement and interpretation of data towards non-invasive molecular sensors that can be integrated in daily wearable items. Towards this goal, this paper explores the potential of embroidered interdigitated transducer (IDT)-based sensors for non-invasive, continuous monitoring of human biomarkers, particularly glucose levels, in human sweat. The study employs innovative embroidery techniques to create flexible fabric-based sensors with gold-coated IDTs. In controlled experiments, we have shown the variation of glucose concentration in water can be wirelessly detected by tracking the resonant frequency of the embroidered sensors. The current sensors operate at 1.8GHz–2GHz and respond to the change of glucose concentration with a sensitivity of 0.17 MHz/(mg/dl). The embroidered IDT-based sensors with wireless sensing will be a new measurement modality for molecular wearable sensors. The establishment of a wireless sensing mechanism for embroidered IDT-based sensors will be followed by investigation of sweat for molecular detection. This will require adding functionalities for sampling and interpretation of acquired data. We envisage the embroidered IDT-based sensors offer a unique approach for seamless integration into clothing, paving the way for personalised, continuous health data capture.

Background: Bronchopulmonary dysplasia (BPD) is the most common respiratory disease in pre-term and is still associated with increased mortality and morbidity. The great interest lies in iden-tifying early biomarkers that can predict the development of BPD. Objectives: This pilot study explores the potential of e-nose for early identification of BPD risk in premature infants by analyzing volatile organic compounds (VOCs) in the exhaled breath con-densate (EBC). Materials and Methods: Fourteen mechanically ventilated very preterm infants were included in the study. Clinical parameters and EBC were collected within the first 24 hours of life. The dis-criminative ability of breath-prints between preterms who did and did not develop BPD was in-vestigated by pattern recognition, machine learning algorithm, and standard statistical methods. Results: We found that e-nose probes can significantly predict the outcome of “no-BPD” vs “BPD”. Specifically, a subset of probes (S18, S24, S14, and S6) were found to be significantly predictive, with an AUC of 0.87, 0.89, 0.82, 0.8 and p=0.019, 0.009, 0.043, 0.047, respectively. Conclusion: The E-nose is an easy-to-use, handheld, non-invasive electronic device that quickly samples breath. Our preliminary study has shown that it has the potential for early prediction of BPD in preterms.

In recent years, the prevalence of tobacco and electronic cigarette (e-cigarette) use among adolescents has raised significant public health concerns worldwide. This study aims to investigate respiratory symptoms among Polish adolescents. We conducted an online survey among Polish school students from all provinces, collecting data over two months in Spring 2021. Students voluntarily complete the anonymous survey, answering questions about respiratory symptoms, smoking habits (both traditional and electronic cigarettes), and demographic information. Analysis focused on four subgroups: non-tobacco users, traditional cigarette smokers, e-cigarette users, and dual users, totaling 10,388 pupils aged 12-18 years, predominantly attending secondary technical and comprehensive schools. A total of 10388 pupils participated in the study, 55.6 % (5778) of whom were girls and 44.4 % (4610) boys. Adolescents, who admitted using both e-cigarettes and traditional cigarettes experienced more frequent episodes of cough during the day (39.70%) and at night (18.40%) compared to their peers in other groups. Chest discomfort, including pain and pressure, was also reported more often by adolescents, who used e-cigarettes and traditional cigarettes concurrently (27.60%) compared to their peers in other groups. Chest pressure was experienced less commonly by non-smoking adolescents (14.40%) than by smokers (18.90%). Higher severity of cough during the day and at night was observed in the group of adolescents using traditional cigarettes and e-cigarettes concurrently compared to the other groups. The adolescents in the dual user group experienced more severe dyspnoea and wheezing compared to the other groups included in the comparison. The results of this study confirm the correlation between the occurrence of respiratory symptoms in adolescents who smoke cigarettes, use e-cigarettes and in dual users. The respiratory symptoms occur most frequently and are the most severe in the group of adolescents who use e-cigarettes and traditional cigarettes

BACKGROUND: Qu-aroma is a critical quality indicator for medium-high temperature Daqu (MT-Daqu), significantly influencing the aroma profile of strong-aroma Baijiu (SAB). SAB is produced across various regions in China, each with unique environmental conditions and production techniques. These regional differences are likely to cause variations in the Qu-aroma of MT-Daqu. Despite this, comprehensive research on the variations in Qu-aroma across different regions has been lacking. This study aims to address this gap by utilizing Gas Chromatography-Olfactometry-Mass Spectrometry (GC-O-MS) and electronic nose (E-nose) technology, combined with sensory evaluation, to analyze the differences in Qu-aroma characteristics and volatile compound profiles of MT-Daqu from seven distinct production areas.RESULTS: Sensory analysis identified seven broad aroma categories and 25 specific aromas characterizing the Qu-aroma of MT-Daqu samples. Chen aroma and roasted aroma were notably more prevalent in MT-Daqu samples from Sichuan compared to those from other regions (P < 0.05), while the fermentation aroma was less prominent in Sichuan samples. In total, 123 volatile compounds were detected in MT-Daqu, with 46 classified as aroma-active compounds. Among these, 21 aroma-active compounds were identified as markers distinguishing Sichuan MT-Daqu from those produced in non-Sichuan regions, showing significant differences in their concentrations (P < 0.05). Additionally, six major aroma-active compounds-ethyl isovalerate, ethyl heptanoate, hexanal, 1-nonanal, (E)-2,4-decadienal, and 2,3-dimethyl-5-ethylpyrazine-were found to significantly contribute to the aroma differences between Sichuan and non-Sichuan MT-Daqu.CONCLUSION: This study delineates the distinct Qu-aroma characteristics of MT-Daqu from various SAB production areas and identifies the aroma-active compounds responsible for these differences. The insights gained from this research offer valuable guidance for optimizing flavor profiles in MT-Daqu production, potentially enhancing the overall quality and regional distinctiveness of the product.

Nymphaea lotus L. is the medicinal plant that has long been used as food, cosmetic and traditional medicines in Africa and Asia since the ancient time. Its flavonoids and other interesting phytochemical compounds from rhizome, leaf, and the whole flowers have been reported in the previous published researches. However, stamens, which are essential for reproductive functions, may also represent new alternative sources of potential antioxidant flavonoids as investigated in this study. The innovative green chemistry method i.e. ultrasound-assisted extraction (USAE) as well as macroporous resin (MPR) purification procedure were employed in this current research. The optimal ultrasound-assisted extraction condition is 90 % (v/v) aqEtOH with 34.65 khz ultrasonic frequency and 46 minutes of extraction time. Comparing with heat reflux extraction (HRE) conventional method, the significant gain of 1.35 total flavonoids content was obtained using optimized USAE conditions, jumping to 2.80 when this USAE associated with MPR purification. Not only in vitro cell free antioxidant activity of N. lotus stamen extracts, but also in cellulo antioxidant investigation using yeast model showed the same trend to indicate that the best antioxidant flavonoid can be found in USAE coupled with MPR purification. Moreover, the key antioxidant genes expression in yeast model such as SIR2 and SOD2 were also expressed at the highest level in yeast cell treated with the extract from USAE together with MPR purification. Consequently, it can be seen that the USAE combined with MPR purification can help to enhance the flavonoids antioxidant potential of the stamens extract from this medicinal species.

The healthcare sector has undergone a profound transformation, owing to the influential role played by IoMT (Internet of Medical Things) technology. However, there are substantial concerns over these devices' security and privacy-preserving nature. Current literature on IoMT tends to focus on specific security features like data confidentiality or data integrity or data availability or access control and most solutions are simulated and not tested in a real-world live network. This paper proposes a smart secure by design solution that safeguards user’s data during health and wellbeing monitoring of patients locally (home, care-home, and hospital) and remotely. The proposed innovative solution is known as Secure by Design Real Time IoMT Architecture for e-Health Population Monitoring (RTPM) for smart hospitals and any healthcare monitoring management. In this system, keys can also be generated by the patient monitoring system independent to maintain high privacy standard and trust during the monitoring process and to enable the IoMT devices run independently even if the server is compromised and are made safe from external exploits to the client nodes. However, the session keys are controlled by the trusted IoMT server to lighten the IoMT devices overheads and the session keys are securely exchanged between the client system and the monitoring server. The proposed RTPM focuses on addressing the major security requirements for an IoMT system: confidentiality, integrity, availability, conducts authentication, protect from DoS attacks and prevent from non-repudiation attack of patient medical data and the devices in a real time, sensory data communication environment for live e-health monitoring. A secure communication is tested by capturing the live network traffic and the system’s performance analysis of RTPM using different security algorithms with different key sizes of RSA, AES, and SHA shows that resource constraint low powered system can also successfully integrate with high-end state-of-the-art secure parameters and features and have the potential to support real time secure interaction. A stress test is also conducted to ensure that the system can withstand huge key sizes and different data types including multi-media information.

Thyroid cancer is the most prevalent malignancy of the endocrine system and the ninth most common cancer globally. Despite the advances in the management of thyroid cancer, there are critical issues with the diagnosis and treatment of thyroid cancer that result in the poor overall survival of undifferentiated and metastatic thyroid cancer patients. Recent studies have revealed the role of different non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are dysregulated during thyroid cancer development or the acquisition of resistance to therapeutics, and may play key roles in treatment failure and poor prognosis of the thyroid cancer patients. Here, we systematically review the emerging roles and molecular mechanisms of ncRNAs that regulate thyroid tumorigenesis and drug response. We then propose the potential clinical implications of ncRNAs as novel diagnostic and prognostic biomarkers for thyroid cancer.

Around one billion people live in informal settlements, globally, including over half of Nairobi, Kenya’s three million residents. The purpose of this study was to explore women’s fear of victimization within Mathare, an informal settlement in Nairobi, Kenya and how fear of victimization influences behavior. Fifty-five in-depth interviews were conducted with women in 2016. A modified grounded theory approach guided data collection and analysis. Findings suggest fear of victimization is a serious concern in informal settlements. Women have found ways to adopt their behaviors that allow them to continue to function and protect their children despite fearing victimization, but at a potential cost to their health and well-being. Thus, there is a critical need for more research focused on social, economic, structural, community, infrastructure, technological, and individual strategies to prevent violence, enhance residents’ sense of safety, and, subsequently, minimize women’s fear of victimization in informal settlements.

Several pathotypes of enteric E. coli have been identified. The group represented by Shiga toxin-producing E. coli (STEC) is of particular interest. Raw milk and raw milk products are significant sources of STEC infection in humans; therefore, identifying pathogens at the herd level is crucial for public health. Most national surveillance programs focus solely on raw milk and raw milk cheeses that are ready for retail sale, neglecting the possibility of evaluating the source of contamination directly at the beginning of the dairy chain. In order to assess the viability of new molecular methodologies applied to raw milk filters enabling the identification of the presence of STEC serotypes in milk production and apply the same methods to identify the presence of these pathogens in calf feces we analyzed, through a commercial real-time PCR assay, a total of 290 samples coming from 18 different dairy herds; 88 bulk tank milk (BTM), 104 raw milk filters (RMF) and 98 calves’ feces samples. In total 3.4% of BTM, 41.4% of RMF and 73.4% of calves’ feces tested positive for stx presence, supporting our hypothesis that BTM is not a suitable matrix to assess the STEC presence at herd level, underestimating it. Our conclusion is that the surveillance program needs critical and extensive improvements such as RMF and calves’ feces analysis implementation in order to be more efficient in detecting and preventing STEC infections. The epidemiology of these infections and the characteristics of the pathogen clearly show how a One Health approach will be pivotal to improve our capabilities to control the spread of these infections.

Periodontitis is a disease that originates from gingival tissue, and if left untreated, can cause inflammation to spread to deeper tissues, altering bone homeostasis, and even leading to tooth loss. When the bacteria in plaque reach sufficient numbers, the immune system responds by activating immune cells that will produce cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). These immune signaling molecules will coordinate the inflammatory responses. IL-1 binds to the IL-1 receptor (IL-1R) on the surface of target cells, initiating an inflammatory response by activating intracellular signalling pathways. Inhibition of IL-1R can prevent the interaction of IL-1 with this receptor, thereby halting the activation of the inflammatory pathway. By substituting this connection with active anti-inflammatory substances, it is possible to prevent the contact between IL-1 and IL-1R. The licorice plant, Glycyrrhiza glabra, includes eight types of flavonoids with significant anti-inflammatory potential, namely isoliquiritigenin, glyzaglabrin, prunetin, shinpterocarpin, licochalcone A, glabridin, glisoflavone, and isoangustone A. This study aims to assess the potential of such flavonoids as candidates for periodontitis treatment through molecular docking, using AutoDock Tools v.1.5.6. All tested compounds showed highly stable bonds to IL-1R, with a binding affinity values below -7 kcal/mol. Van der Waals forces, hydrogen bonds, and hydrophobic bonds all contribute to the stability of these interactions. Among the eight tested compounds, glisoflavone, which has a Ki value of 90.89 nM and a ΔG value of -9.61 kcal/mol, has the highest binding stability to IL-1R.

An in vitro medium-throughput screen using M. tuberculosis H37Rv was employed to screen an in-house library of structurally diverse compounds for antimycobacterial activity. From this initial screen, eleven 7-substituted coumarin derivatives with confirmed monoamine oxidase-B and cholinesterase inhibitory activities, demonstrated growth inhibition of more than 50% at a 50 µM concentration. This prompted further exploration of all the 7-substituted coumarins in our library, nineteen in total, as potential antimycobacterial agents. Four derivatives showed promising antimycobacterial activity with MIC₉₉ values of 8.31 – 29.70 µM and 44.15 – 57.17 µM on M. tuberculosis H37Rv in independent assays using Gaste-Fe and 7H9 + OADC media, respectively. These compounds were found to bind to albumin which may explain the variations in MIC between the two assays. Preliminary antimycobacterial evaluation of moxifloxacin resistant M. tuberculosis show that these compounds are able to maintain their activity in fluoroquinolone resistant mycobacteria. Analysis of structure activity relationships for antimycobacterial versus neuronal enzyme inhibitory activity indicate that structural modification on position 4 and/or 7 of the coumarin scaffold may be utilized to improve selectivity towards either inhibition of neuronal enzymes or antimycobacterial effect. Cytotoxicity evaluations of the compounds indicate moderate cytotoxicity with slight selectivity towards mycobacteria. Further neuroprotective assays on SH-SY5Y human neuroblastoma cells indicate significant neuroprotection for selected compounds irrespective of their neuronal enzyme inhibitory properties. These coumarin molecules are thus interesting lead compounds that may provide insight into the design of new antimicrobacterial and/or neuroprotective agents.

Background: Diagnostic accuracy of Parkinson’s disease (PD), a synucleinopathy, based on diagnostic criteria is suboptimal. A biomarker for synucleinopathies is pivotal both from a clinical and from a research aspect. CSF a-synuclein has been extensively studied over the past two decades as a candidate biomarker of synucleinopathies. Herein we present data on studies focusing on total, phosphorylated and oligomeric CSF a-synuclein in PD. Methods: Pubmed, Scopus and Web of Science were searched for studies with &gt;10 PD patients and control subjects, with data (mean, SD) on total, phosphorylated or oligomeric a-synuclein. Cohen’s d, as a measure of effect size, was calculated for all a-synuclein forms. Subgroup analysis and meta-regression were performed in an effort to explain between-study heterogeneity. Results: Thirty studies on total, six studies on oligomeric and one study on phosphorylated a-synuclein were included. Total a-synuclein was decreased and oligomeric a-synuclein increased in PD patients vs. controls. Effect size was medium for total and high for oligomeric a-synuclein. A-syn forms provided suboptimal combined sensitivity/specificity for the differentiation of PD from controls. There was significant between-study heterogeneity. PD cohort characteristics (sex, age, disease duration, UPDRS, H&amp;Y) and study characteristics (study design, healthy vs. neurological controls, control for CSF blood contamination, method of a-syn measurement) could not account for between-study heterogeneity. Publication bias was limited. Conclusions: CSF a-synuclein levels lack sufficient accuracy to be used as biomarkers for PD. Standardization of (pre)analytical variables may improve the discriminatory power of a-synuclein forms in the future.

Objective: To examine the dose-response relationship between average daily temperature and sunlight hours with daily steps across a 35-week period in school-aged children, and to evaluate whether there were differences by sex. Methods: We conducted a follow-up study involving 655 children (50.8% girls, mean age 10.45 ± 0.95) from six public primary schools in Cuenca, Spain. We measured daily steps using Xiaomi Mi Band 3 Smart Bracelets from October 2022 to June 2023 (over 35 weeks). We collected daily average temperature from the local weather station in Cuenca and sunlight hours during the same period. We used ANCOVA models and LOESS regression to examine the dose-response relationship between average daily temperature and daily hours of sunlight with daily steps. Additionally, we performed a multiple linear regression model. Results: Our findings revealed significant variations in daily steps across the 35 weeks. The relationship between environmental factors and daily steps was non-linear, in both girls and boys. The optimal values for higher activity levels were an average temperature of 14°C and 13 hours of sunlight. Furthermore, a 1 ºC increase in temperature was associated with an increase of 74 ± 130 steps/day, while an increase of one hour of sunlight was associated with an increase of 315 ± 237 steps/day. However, sunlight hours may act as a moderating factor. Conclusion: Our study showed a non-linear association between t average daily temperature and sunlight hours with daily steps over a 35-week period. Additional strategies may be necessary to encourage increased physical activity during periods of extreme temperatures or sunlight exposure.

The adverse relationship between viral hepatitis and pregnancy in developing countries was seen as a reflection of retrospective biased hospital-based data collection by the West. However, the discovery of HEV from an epidemic of non-A, non-B hepatitis in Kashmir and documenting increased incidence and severity of hepatitis E in pregnancy from a house-to-house survey unmasked the unholy alliance. Among the family of HEV’s, genotype (gt)-1, with a unique ORF4-encoded protein enhancing viral polymerase activity and viral replication, is the sole HEV that shows this adverse relationship. The epidemics caused by HEV-gt1 and not by HEV-gt2 show adverse relationship with pregnancy. The pathogenesis of the unholy alliance is complex and at present not well understood. Possibly multiple factors play a role in causing severe liver disease in the mother including: infection, replication and damage to the maternal-foetal interface by HEV-gt1; vertical transmission of HEV to foetus causing severe foetal/neonatal hepatitis; and combined viral and hormone related immune dysfunction of diverse nature in the mother promoting viral replication. Management is multidisciplinary and needs a close watch for the development and management of ALF. Preliminary data suggest beneficial maternal outcomes by early termination of pregnancy in patients with lower grades of encephalopathy.

According to the World Health Organization, approximately 20 million people worldwide are infected annually with the hepatitis E virus (HEV). There are 4 main genotypes of HEV. Genotype 1 and genotype 2 are common in developing countries and are transmitted by contaminated water from a fecal-oral route. Genotype 3 and genotype 4 are common in developed countries and can lead to occasional transmission to humans by undercooked meat. Hepatitis E virus 1 and HEV3 can lead to fulminant hepatitis, and HEV3 can lead to chronic hepatitis and cirrhosis in immunocompromised patients. The majority of patients with HEV infection are asymptomatic and usually have spontaneous viral clearance without treatment. However, infection in immunocompromised individuals can lead to chronic HEV infection. Both acute and chronic HEV infections can have extrahepatic manifestations. No specific treatment is required for acute HEV infection, no treatment has been approved in chronic infection and no HEV vaccine has been approved by the (United States) Food and Drug Administration. This review focuses on the molecular virology (HEV life cycle, genotypes, model systems, zoonosis), pathogenesis, clinical manifestation, and treatment of chronic HEV infection, especially in immunocompromised patients, to provide clinicians a better understanding of the global distribution of these infections and the significant effect they can have on immunocompromised patients.

Background and Objectives: In recent years Electronic scooters (E-Scooters) have gained popularity, whether for private use or as a publicly available transportation method. With introduction of these vehicles, reports of E-Scooter related accidents have surged, sparking a public debate and concern. Aim of this study was to analyse epidemiological data, characteristics and severity of traumatic brain injury (TBI) related to E-Scooter accidents. Materials and Methods: This retrospective case series evaluated 28 patients who were admitted to three largest neurosurgery clinics in Riga, Latvia between time period from April to October in two separate years – 2022 and 2023 after an E-Scooter related accident. Data were collected on patient demographics, time of the accident, alcohol consumption, helmet use, type of TBI, other related injuries, treatment and assessment at discharge. Results: A total of 28 patients were admitted with TBI related to E-Scooter use, with median age 30 years (Q1-Q3, 20.25-37.25), four individuals under age of 18, majority (64%) were male. In 23 cases the injury mechanism was fall, in 5 cases collision. None were wearing a helmet at time of injury. Alcohol intoxication was evident in over half of the patients (51.5%), with severe intoxication (&gt;1.2ppm) in 75% cases among them. Neurological symptoms upon admission were noted in 50% of cases. All patients had intracranial trauma - 50% brain contusions, 43% traumatic subdural hematoma, almost 30% - epidural hematoma. Craniofacial fractures were evident in 71% of cases, fractures in other parts of body in 3 patients. 6 patients required emergency neurosurgical intervention. Neurological complications were noted in 2 patients, 1 patient died. Conclusions: E-Scooter related accidents result in a significant number of brain and other associated injuries, with notable frequency linked to alcohol influence and lack of helmet use. Prevention campaigns to raise awareness of potential risks and implementation of more strict regulations should be done.

This research focuses on the effect of trampling on vegetation in high-mountain ecosystems through the electromagnetic spectrum’s interaction with plant pigments, cell structure, water content and other substances that have a direct impact on leaf properties. The most heavily visited part of the High Tatras in Poland was divided into polygons and, after selecting the dominant species within alpine swards, a detailed analysis of trampled and reference patterns was performed. An ASD FieldSpec 3 was used to acquire high-resolution spectral properties of plants, their fluorescence and the leaf chlorophyll content with the ts-ta temperature index and fraction of accumulated radiation in the range of photosynthesis (fAPAR) used as reference data. The results show that, along tourist trails, vegetation adapts to trampling with the impact depending on the species. A lower chlorophyll value was confirmed by a decrease in fluorescence, and the state of cellular structures was degraded in trampled compared to reference species, with a lower leaf reflectance. Also, at the extreme, trampling can eliminate certain species such as Luzula alpino-pilosa.

In recent years, many libraries and archives have started digitizing their collections thus making maps by Indigenous peoples more easily available for scholars to study. While a number of these maps were discussed by G. Malcolm Lewis in the History of Cartography series (volume 2, book 3, Chapter 4: 1984), more have since been found and disseminated. These maps are critical in understanding the historic and current land tenure of Indigenous groups. Further, Indigenous claims to land can be seen in their connections via toponymy. European concepts of territory and political boundaries did not coincide with First Nation/American Indian views resulting in the mistaken view that Natives did not have formal concepts of their territories. Further, Tribes/First Nations with cross-border territory have special jurisdictional problems. This paper will illustrate how many Native residents were very spatially cognizant of their own lands, as well as neighboring nations’ lands, overlaps between groups, hunting territories, populations, and trade networks. Currently, the Sinixt First Nation provides a perfect example of how an Aboriginal people are inputting and using a GIS representation of their territory with proper toponymy and use areas.

As customer demand for green products increases in the digital economic era, this study analyses the green innovation of the e-tailer and supplier in drop shipping models. Moreover, drop shipping e-tailers and suppliers with a drop shipping option need to make choices regarding whether to provide green or normal products to the market. When a supplier with a drop shipping option produces green products, more fees may be invested on the production of green products than on normal products. The drop shipping e-tailers and suppliers with a drop shipping option can also choose to sell normal products at a low cost, as before. This study designs four models of drop shipping e-teilers and suppliers with a drop shipping option under different choices, analyzes their operational process in drop shipping models, and investigates five theorems. The optimal pricings decisions and green degree of drop shipping e-tailers and suppliers with a drop shipping option were evaluated in this study. The impacts of the green innovation factor, green elasticity coefficient, manufacturing and distribution costs on the drop shipping e-tailers and suppliers with a drop shipping option, and the effect of other environmental parameters on the green degree of green products are also analyzed through computer simulation. The findings of the simulation analysis provide valuable guidance for e-tailers and suppliers with green innovation in drop shipping models and offer important academic and practical implications for e-commerce and the digital economy.