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Preprint ARTICLE | doi:10.20944/preprints202308.0853.v1

Assessing the Optimal Contributions of Renewables and Carbon Capture and Storage toward Carbon Neutrality by 2050

Dinh Hoa Nguyen, Andrew Chapman, Takeshi Tsuji

Subject: Engineering, Energy And Fuel Technology Keywords: carbon neutrality; renewables; carbon capture and storage; emission trading system; optimization, socioeconomic analysis.

Online: 10 August 2023 (11:13:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0028.v1

Pore Pressure Analysis for Distinguishing Earthquakes Induced by CO2 Injection from Natural Earthquakes

Chanmaly Chhun, Takeshi Tsuji

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: pore pressure; CO2 injection; induced earthquakes; seasonal earthquakes; remote earthquakes; seismogenic faults

Online: 2 November 2020 (11:17:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.1092.v1

Survey on Fungi in Antarctica and High Arctic Regions, and Their Impact on Climate Change

Masaharu Tsuji

Subject: Environmental And Earth Sciences, Ecology Keywords: Antarctica; High Arctic; fungi; climate change

Online: 17 July 2023 (09:48:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1360.v1

A Framework Analyzing Co-Creation Value Chain Mechanism in Community-Based Approach: A Literature Review

Satoshi Ohnishi, Masahiro Osako, Shogo Nakamura, Takashi Tsuji, Takuya Togawa, Kosuke Kawai, Kaoru Suzuki, Aya Yoshida, Kei Gomi

Subject: Environmental And Earth Sciences, Other Keywords: Collective Impact; Social Impact Assessment; Community Capital Framework

Online: 19 May 2023 (02:45:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0511.v1

Optic Nerve Injury Enhanced Mitochondrial Fission and Increased Mitochondrial Density without Altering the Uniform Mitochondrial Distribution in the Unmyelinated Axons of Retinal Ganglion Cells in a Mouse Model

Takahiro Tsuji, Tomoya Murase, Yoshiyuki Konishi, Masaru Inatani

Subject: Medicine And Pharmacology, Ophthalmology Keywords: glaucoma; optic neuropathy; mitochondria; optic nerve crush; confocal scanning ophthalmoscope; distribution; Thy1-mito-YFP mice

Online: 28 January 2023 (03:05:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1490.v1

High Dose Rate 192Ir Brachytherapy Source Model Monte Carlo Dosimetry: mHDR-v2 and mHDR-v2r

Shuhei Tsuji, Naomasa Narihiro, Masataka Oita, Yoshihito Namito, Hideo Hirayama

Subject: Physical Sciences, Radiation And Radiography Keywords: Ir-192; HDR brachytherapy; dosimetry; Monte Carlo; EGS5

Online: 21 July 2023 (09:24:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0375.v1

How Essential Kinesin-5 Becomes Non-Essential: Force Balance and Microtubule Dynamics Matter

Masashi Yukawa, Yasuhiro Teratani, Takashi Toda

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: bipolar mitotic spindle; fission yeast; kinesin; kinetochore; microtubule dynamics; microtubule polymerase; microtubule–associated proteins (MAPs); spindle pole body (SPB); sister chromatid cohesion

Online: 21 April 2020 (05:58:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0139.v1

Estimation of Cough Peak Flow Using Cough Sounds

Yasutaka Umayahara, Zu Soh, Kiyokazu Sekikawa, Toshihiro Kawae, Akira Otsuka, Toshio Tsuji

Subject: Medicine And Pharmacology, Other Keywords: cough sound; cough peak flow; microphone; cough ability; cough strength; bone conduction microphone; smartphone

Online: 8 June 2018 (13:45:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0206.v1

Characterization and Comparison of CubeSat and Drone Platform Jitter Effects on Laser Beam Pointing Stability

Femi Ishola, Alberto Carrasco-Casado, Rodrigo Cordova, Hirokazu Masui, Yasushi Munemasa, Phuc V. Trinh, Tetsuharu Fuse, Hiroyuki Tsuji, Mengu Cho, Morio Toyoshima

Subject: Engineering, Electrical And Electronic Engineering Keywords: Laser Communications; Platform Jitter; Beam-pointing stability; Drone; CubeSat

Online: 11 August 2022 (03:38:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0060.v1

Two XMAP215/TOG Microtubule Polymerases, Alp14 and Dis1, Play Non-exchangeable, Distinct Roles in Microtubule Organisation in Fission Yeast

Masashi Yukawa, Tomoki Kawakami, Corinne Pinder, Takashi Toda

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: fission yeast; microtubule polymerase; xmap215/tog; mitotic spindle; spindle pole body; kinetochore

Online: 7 October 2019 (11:02:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0452.v1

The Putative RNA-Binding Protein Nrp1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered Into Heat-Induced Protein Aggregates in Fission Yeast

Masashi Yukawa, Mitsuki Ohishi, Yusuke Yamada, Takashi Toda

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: fission yeast; kinesin-14; RNA-binding protein; mitotic spindle; heat stress

Online: 17 March 2021 (16:52:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1167.v1

Pulsation Measurement on Stator Side for Turbo Charger Turbine Blade Vibration Monitoring - Effect of Mistuning and Blade Passing Frequencies on Integral Mode Blade Vibration Detections

Takashi Ando

Subject: Engineering, Energy And Fuel Technology Keywords: Turbocharger turbine blade vibration monitoring,; Pulsation measurement; Nozzle ring fouling; Mistuning; Blade passing frequencies

Online: 16 June 2023 (08:32:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1385.v1

Experimental Study: Interleukin-31 Augments Morphine-induced Antinociceptive Activity and Suppress Tolerance Development in Mice

Iwao Arai, Minoru Tsuji, Saburo Saito, Hiroshi Takeda

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: analgesia; antinociception; interleukin-31 (IL-31); interleukin receptor A (IL-31RA); IL-31 receptor A-deficient (IL-31RAKI) mice; itch; morphine; pain

Online: 23 October 2023 (10:11:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1347.v1

Lactococcus lactis subsp. cremoris C60 Upregulates Macrophage Function by Modifying Metabolic Preference in Enhanced Anti‐Tumor Immunity

Suguru Saito, Duo-Yao Cao, Toshio Maekawa, Noriko Tsuji, Alato Okuno

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: probiotics; macrophage; anti‐tumor immunity; glycolysis; ATP

Online: 19 April 2024 (15:22:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0041.v1

Association between Excessive Use of Mobile Phone and Insomnia and Depression among Japanese Adolescents

Tamura Haruka, Tomoko Nishida, Akiyo Tsuji, Hisataka Sakakibara

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: adolescents; depression; insomnia; mobile phone; Japanese

Online: 7 April 2017 (04:33:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1971.v1

Small-scale marine fishers’ possession of fishing vessel and its impact to their net income level: A Case Study in Takalar District, South Sulawesi Province of Indonesia

Ahmad Imam Muslim, Miho Fujimura, Tsuji Kazunari, Muslim Salam

Subject: Business, Economics And Management, Economics Keywords: Small-scale fisher, Fishers’ boat, Net income level of fishers, Row boat, Outboard motor boat, Motor boat

Online: 28 July 2023 (11:44:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0435.v1

Relationship between Acceleration in a Sit-to-Stand Movement and Physical Function in Older Adults

Korin Tateoka, Taishi Tsuji, Takuro Shoji, Satoshi Tokunaga, Tomohiro Okura

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: acceleration parameters; chair-rise; performance test

Online: 8 October 2023 (08:13:04 CEST)

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Working Paper ARTICLE

Protective Effects of GIC and S-PRG Filler Restoratives on Demineralization of Bovine Enamel in Lactic Acid Solution

Naoyuki Kaga, Futami Nagano-Takebe, Takashi Nezu, Takashi Matsuura, Kazuhiko Endo, Masayuki Kaga

Subject: Chemistry And Materials Science, Biomaterials Keywords: pH neutralization; ion release; enamel demineralization; glass ionomer cement; surface pre-reacted glass ionomer filler

Online: 5 May 2020 (04:22:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1123.v1

Analyzing the Antinociceptive Effect of Interleukin-31 in Mice

Iwao Arai, Minoru Tsuji, Saburo Saito, Hiroshi Takeda

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: analgesia; alloknesis; antinociception; interleukin-31 (IL-31); interleukin receptor A (IL-31RA); IL-31 receptor A deficient (IL-31RAKI) mice; itch; pain.

Online: 16 May 2023 (08:19:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1453.v1

The Roles of Four Important Contexts in Japan’s Carbon Neutrality Policy and Politics, 1990–2020

Christo Odeyemi, Takashi Sekiyama

Subject: Social Sciences, Political Science Keywords: carbon neutrality; climate policy; climate politics; fairness under the Kyoto Protocol; Keidanren; Japan

Online: 21 September 2023 (07:24:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0216.v1

Glacier Retreat Results in Loss of Fungal Diversity

Masaharu Tsuji, Warwick F Vincent, Yukiko Tanabe, Masaki Uchida

Subject: Environmental And Earth Sciences, Environmental Science Keywords: glacial retreat; Walker Glacier; endangered fungi; climate change; mycoflora

Online: 14 January 2022 (15:02:53 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202403.0854.v1

A Proposal of Geoengineering Method as Global Warming Countermeasure： Stratospheric O3 Increase to Reduce Earth＇s Surface Temperature

Takashi Ohmori

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: geoengineering; global warming countermeasure; stratospheric O3

Online: 14 March 2024 (11:54:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0169.v1

Resistance and Tolerance to Viroid Infection

Takashi Naoi, Shifang Li, Teruo Sano

Subject: Biology And Life Sciences, Virology Keywords: viroid; resistance; tolerance; RNA silencing; plant hormone; spray-induced gene silencing; genome editing

Online: 9 November 2022 (03:10:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0366.v1

Effectiveness of Sports-Nutrition Education Based on Self-Determination Theory for Male University Rowing Athletes: A Randomized Controlled Trial

Naoko Enatsu, Jun Seino, Taishi Tsuji, Mitsugi Ogata

Subject: Social Sciences, Education Keywords: Sports nutrition knowledge; Treatment self-regulation questionnaire; Brief-type self-administered diet history questionnaire; Intervention study; Nutrition education; Male Athletes

Online: 6 February 2024 (13:06:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.1301.v1

MicroRNAs as Biomarkers and Therapeutic Targets for Acute Kidney Injury

Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura, Jun Wada

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: microRNA; acute kidney injury; biomarker; mesenchymal stem cell.

Online: 18 August 2023 (10:57:53 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202407.1621.v1

Oral Supplementation of L-Carnosine Attenuates Acute Stress-Induced Corticosterone Release and Mitigates Anxiety in CD157 Knockout Mice

Takahiro Tsuji, Kazumi Furuhara, Erchu Guo, YiJing Wu, Jing Zhong, Haruhiro Higashida, Yasuhiko Yamamoto, Chiharu Tsuji

Subject: Biology And Life Sciences, Other Keywords: L-carnosine; CD157; autism spectrum disorder; corticosterone; anxiety; stress

Online: 19 July 2024 (15:15:43 CEST)

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Working Paper ARTICLE

Multimodal-Multisensory Experiments

Moein Razavi, Takashi Yamauchi, Vahid Janfaza, Anton Leontyev, Shanle Longmire-Monford, Joseph Orr

Subject: Social Sciences, Psychology Keywords: multimodal experiment; multisensory experiment; automatic device integration; open-source; PsychoPy; Unity; Virtual Reality (VR); Lab Streaming Layer; LabRecorder; LabRecorderCLI; Windows command line (cmd.exe)

Online: 12 October 2020 (07:06:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1219.v1

Usefulness of Perioperative Nutritional Therapy with the Glutamine/Arginine/Calcium β-Hydroxy-β-Methylbutyrate Product in Esophageal Cancer Surgery: A Single-Center Retrospective Study

Koichi Okamoto, Hiroyuki Takamura, Taigo Nagayama, Yuta Sannomiya, Akifumi Hashimoto, Hisashi Nishiki, Daisuke Kaida, Takashi Miyata, Toshikatsu Tsuji, Hideto Fujita, Shinichi Kinami, Itasu Ninomiya, Noriyuki Inaki

Subject: Medicine And Pharmacology, Surgery Keywords: esophageal cancer; minimally invasive esophagectomy; complication; sarcopenia

Online: 18 June 2024 (11:29:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0651.v1

Opensync: An Opensource Platform for Synchronizing Multiple Measures in Neuroscience Experiments

Moein Razavi Ghods, Vahid Janfaza, Takashi Yamauchi, Anton Leontyev, Shanle Longmire-Monford, Joseph Orr

Subject: Social Sciences, Psychology Keywords: multiple measures synchronization; automatic device integration; open-source; PsychoPy; Unity

Online: 29 July 2021 (11:48:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.2093.v1

Semaphorin 3A Signaling in Kidney Development and Diseases

Yizhen Sang, Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura, Jun Wada

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: semaphorin 3A; neuropilin-1; podocyte; diabetic nephropathy; acute kidney injury; chronic kidney injury; lupus nephritis; fibrosis; apoptosis; inflammation

Online: 31 August 2023 (02:53:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1300.v1

3EE, 20Ac-Ingenol Decreases HIF-1α/PD-L1 through ATR Activation under Hypoxia and Induces Apoptosis in Panc-1 Cells Accumulating Cyclin D1

Shohei Miyata, Takashi Ishii, Susumu Kitanaka

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Apoptosis; PD-L1; catalytic topo I inhibitor; cyclin D1 overexpression; ATR; p53

Online: 18 May 2023 (08:31:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0262.v1

Non-cognitive Skills and the Parent–child Relationship: A Cross-sectional Study

Hiromi Suzuki, Nobuyuki Miyatake, Takashi Kusaka

Subject: Social Sciences, Psychology Keywords: adolescent; grit; non-cognitive skills; parent–child relationship; self-control

Online: 19 December 2019 (13:21:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0417.v1

Generation-common and -specific factors in intention to leave among female hospital nurses: A cross-sectional study using a large Japanese sample

Maki Tei-tominaga, Kyoko Asakura, Takashi Asakura

Subject: Public Health And Healthcare, Nursing Keywords: female, generation, hospital, intention to leave, nurse

Online: 26 June 2018 (12:34:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1277.v1

Investigating the Effects of Parameter Tuning on Machine Learning for Occupant Behavior Analysis in Japanese Residen-tial Buildings

Kaito Furuhashi, Takashi Nakaya

Subject: Engineering, Architecture, Building And Construction Keywords: Occupant behavior; Machine learning; Feature selection; Parameter tuning

Online: 18 May 2023 (05:27:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0903.v1

Modeling of Sulfur and Iron Dynamics in Enclosed Bay Sediments and Evaluation of the Suppression Effect on Sulfides Release by Iron

Fumika Mochida, Takashi Miyatsuji, Yoshiyuki Nakamura, Tetsunori Inoue

Subject: Engineering, Civil Engineering Keywords: sediment model; sulfur and iron cycles; semi-enclosed bay

Online: 12 May 2023 (08:11:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0276.v1

Polarization Anisotropies in Strain-Free, Asymmetric and Symmetric Quantum Dots Grown by Droplet Epitaxy

Marco Abbarchi, takaaki mano, takashi kuroda, kazuaki sakoda

Subject: Physical Sciences, Acoustics Keywords: quantum dot; droplet epitaxy

Online: 14 January 2021 (14:34:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2005.v1

Hadamard’ Variational Formula for Simple Eigenvalues

Takashi Suzuki, Takuya Tsuchiya

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: eigenvalue problem; perturbation theory of linear operators; domain deformation; Hadamard's variational formula; Garabadian-Schiffer's formula

Online: 28 August 2024 (10:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0140.v1

Relationships among Physical Activity, Physical Function, and Food Intake in Older Japanese Adults Living in Urban Areas: A Cross-sectional Study

Takashi Fushimi, Kyoko Fujihira, Hideto Takase, Masashi Miyashita

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: quality of life; physical activity; physical function; food and nutrition; older Japanese adults

Online: 9 January 2023 (06:32:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1005.v1

Prediction of Hedonic Ratings of Different Drinks Based on Facial Expressions

Yasuyo Matsufuji, Kayoko Ueji, Takashi Yamamoto

Subject: Biology And Life Sciences, Food Science And Technology Keywords: taste; hedonic rating; facial expressions; emotion; estimation

Online: 14 August 2023 (09:37:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0692.v1

The Ryanodine Receptor as a Sensor for Cellular Environments in Muscles

Takuya Kobayashi, Nagomi Kurebayashi, Takashi Murayama

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Ryanodine receptor; skeletal muscle; cardiac muscle; exercise and injury; heart function; diet

Online: 29 June 2021 (08:37:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0205.v1

Potential Role of NRF2 Agonist in Managing AHR-Mediated Chloracne by Dioxin

Masutaka Furue, Yoko Fuyuno, Chikage Mitoma, Hiroshi Uchi, Gaku Tsuji

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Aryl hydrocarbon receptor; Chloracne; Dioxin; Nuclear factor-erythroid 2-related factor-2; heme oxygenase-1; Yusho

Online: 13 June 2018 (10:29:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1199.v1

Live Cell Imaging by Single-Shot Common-Path Wide Field-of-View Reflective Digital Holographic Microscope

Manoj Kumar, Takashi Murata, Osamu Matoba

Subject: Physical Sciences, Optics And Photonics Keywords: quantitative phase imaging; digital holographic microscopy; live cell imaging.

Online: 16 January 2024 (14:00:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0428.v1

Proof of Concept Study for Increasing Tenascin-C-targeted Drug Delivery to Tumors Previously Subjected to Therapy: X-Irradiation Increases Tumor Uptake

Aya Sugyo, Atsushi B. Tsuji, Hitomi Sudo, Kanako Takano, Moriaki Kusakabe, Tatsuya Higashi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Injured tissue; Tissue remodeling; Treatment resistance; Radioisotope; Cancer stroma

Online: 21 October 2020 (10:36:25 CEST)

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Background: In treatment-refractory cancers, tumor tissues damaged by therapy initiate the repair response; therefore, tumor tissues must be exposed to an additional burden before successful repair. We hypothesized that an agent recognizing a molecule that responds to anticancer treatment–induced tissue injury could deliver an additional antitumor agent including a radionuclide to damaged cancer tissues during repair. We selected the extracellular matrix glycoprotein tenascin-C (TNC) as such a molecule, and three antibodies recognizing human and murine TNC were employed to evaluate X-irradiation–induced changes in TNC uptake by subcutaneous tumors. Methods: TNC expression was assessed by immunohistochemical staining of BxPC-3 tumors treated with or without X-irradiation (30 Gy) for 7 days. Antibodies against TNC (3-6, 12-2-7, TDEAR) and a control antibody were radiolabeled with 111In and injected into nude mice having BxPC-3 tumors 7 days after X-irradiation, and temporal uptake was monitored for an additional 4 days by biodistribution and single-photon emission computed tomography with computed tomography (SPECT/CT) studies. Intratumoral distribution was analyzed by autoradiography. Results: The immunohistochemical signal for TNC expression was faint in nontreated tumors but increased and expanded with time until day 7 after X-irradiation. Biodistribution studies revealed increased tumor uptake of all three 111In-labeled antibodies and the control antibody. However, a statistically significant increase in uptake was evident only for 111In-labeled 3-6 (35%ID/g for 30 Gy vs. 15%ID/g for 0 Gy at day 1, P < 0.01; ID, injected dose), whereas limited changes in 111In-labeled TDEAR2, 12-2-27, and control antibody were observed (several %ID/g for 0 and 30 Gy). Serial SPECT/CT imaging with 111In-labeled 3-6 or control antibody provided consistent results. Autoradiography revealed noticeably stronger signals in irradiated tumors injected with 111In-labeled 3-6 compared with each of nonirradiated tumors and the control antibody. The signals were observed in TNC-expressing stroma. Conclusion: Markedly increased uptake of 111In-labeled 3-6 in irradiated tumors supports our concept that an agent, such as an antibody, that recognizes a molecule, such as TNC, involved in tissue-injury repair could enhance drug delivery to therapy-experienced tumor tissues. The combination of antibody 3-6 coupled to a tumoricidal drug and conventional therapy has the potential to achieve better outcomes for patients with refractory cancer.

Preprint ARTICLE | doi:10.20944/preprints201806.0124.v1

Carapanosins D—F from the Seeds of Andiroba (Carapa guianensis, Meliaceae) and Their Effects on LPS-Activated NO Production

Takanobu Inoue, Shoko Ohmori, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Carapa guianensis; Meliaceae; andiroba; seeds; limonoids; seco-phragmalin; mexicanolide; carapanosins A—C; NO production

Online: 7 June 2018 (15:06:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0978.v1

Oncostatin M’s Involvement in the Pathogenesis of Chronic Rhinosinusitis: Focus on Type 1 and 2 Inflammation

Chie Ishikawa, Sachio Takeno, Yukako Okamoto, Tomohiro Kawasumi, Takashi Kakimoto, Kota Takemoto, Manabu Nishida, Takashi Ishino, Takao Hamamoto, Tsutomu Ueda, Akio Tanaka

Subject: Medicine And Pharmacology, Otolaryngology Keywords: paranasal sinus; chronic rhinosinusitis; CRS; epithelial cell; eosinophil; oncostatin M; OSM; OSM receptor; OSMR

Online: 17 October 2023 (08:05:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1541.v1

Sound-Absorbing, Thermal-Insulating Material Based on Poly (methylsiloxane) Xerogel and Cellulose Nanofibers

Daiji Katsura, Tetsuya Maeda, Kazuyoshi Kanamori, Takashi Yamamoto, Joji Ohshita

Subject: Engineering, Automotive Engineering Keywords: porous material; sound absorption; thermal insulation; heat insulation; poly(methylsiloxane) xerogel; cellulose nanofiber; microstructure modeling; homogenization method

Online: 22 January 2024 (04:36:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0029.v1

Exciton Dynamics in Droplet Epitaxial Quantum Dots Grown on (311)A Oriented Substrates

Marco Abbarchi, Takaaki Mano, Takashi Kuroda, Kazuaki Sakoda

Subject: Physical Sciences, Condensed Matter Physics Keywords: III-V Quantum dots; Droplet Epitaxy; exciton dynamics; (311)A oriented substrate

Online: 2 August 2020 (12:35:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1335.v1

Sesamin Exerts Antioxidative Effect by Activating Nrf2 Transcription Factor in Glial Cells of Central Nervous System in Drosophila Larvae

Akihiro Tsuji, Eiji Kotani, Yoshihiro H. Inoue

Subject: Biology And Life Sciences, Life Sciences Keywords: Sesamin; Nrf2; glial cells; cytochrome P450; Drosophila

Online: 21 May 2024 (17:22:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1320.v1

Severe Type 2 Inflammation Leads to High PAF-Associated Pathology in Chronic Rhinosinusitis with Nasal Polyps (CRSwNP): Hierarchal Cluster Analysis Using Bulk RNA Barcoding and Sequencing

Takashi Ishino, Takashi Oda, Tomohiro Kawasumi, Kota Takemoto, Manabu Nishida, Yuichiro Horibe, Nobuyuki Chikuie, Takayuki Taruya, Takao Hamamoto, Tsutomu Ueda, Sachio Takeno

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Paranasal sinuses; Chronic rhinosinusitis (CRS); BRB-seq; Nasal polyps; Differentially Expressed Genes (DEG) analysis; Hierarchal analysis; Pathway analysis; Type 2 inflammation; LPCAT1; LPCAT2, PAFAH1B2, PAFAH1B3; PAFAH2; PTAFR

Online: 17 January 2024 (13:57:17 CET)

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Platelet-activating factor (PAF) is a phospholipid-derived inflammatory mediator, triggering various inflammatory conditions, including eosinophil activation and recruitment. Despite the unclear mechanism underlying the formation and maintenance of nasal polyp in chronic rhinosinusitis with nasal polyps (CRSwNP), there is strongly indication of its association with type 2 inflammation. This study aimed to quantify PAF-associated gene expression, examining enzymes involved in PAF synthesis (lysophosphatidylcholine acyltransferase 1 (LPCAT1), LPCAT2, LPCAT3, and LPCAT4), and PAF degradation (PAF acetylhydrolases 1 B2 (PAFAH1B2), PAFAH1B3, and PAF acetylhydrolases 2 (PAFAH2)), and PAF receptor (PTAFR). Transcriptomic analysis encompassed CRSwNP, including eosinophilic CRS (ECRS) (n=9), nonECRS (n=8), and a subgroup of ECRS with aspirin exacerbated respiratory disease (Asp) (n=3) based on the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) criteria. Gene expression profiles from nasal polyps in CRSwNP patients and the uncinate process in normal subjects (controls) (n=6) were analyzed using bulk RNA barcoding and sequencing (BRB-seq). Hierarchal analysis, utilizing the average linkage method with iDEP1.1, clarified the relationship between Differentially Expressed Genes (DEG) expressions and cluster formation. Two clusters (cluster 1 (n=11) and cluster 2 (n=9)) of CRSwNP divided by hierarchal analysis showed distinct gene expression profiles in the specific pathway of “cytokine-cytokine receptor interaction” in KEGG pathway and upregulated type 2 inflammatory gene expression in cluster 2. In CRSwNP subclassification of ECRS, nonECRS, and Ctrl, PTAFR was only upregulated in ECRS and nonECRS. In cluster analysis, cluster 1 showed significant downregulation of LPCAT2 and upregulation of PTAFR expression, while cluster 2 showed significant upregulation of LPCAT1, PAFAH1B2, and PTAFR and downregulation of PAFAH2 expression. These findings suggest that cluster 2, characterized by severe type 2 inflammatory gene expression, manifest a prominent PAF-associated pathophysiology. Understanding this high PAF-associated pathophysiology in cluster 2 could provide valuable insights into the treatment and management of CRSwNP.

Preprint ARTICLE | doi:10.20944/preprints202106.0572.v1

Base-Mediated Claisen Rearrangement of CF3-Containing Bisallyl Ethers

Yoko Hamada, Rio Matsunaga, Tomoko Kawasaki-Takasuka, Takashi Yamazaki

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Claisen rearrangement; isomerization; trifluoromethyl; Cieplak rule

Online: 23 June 2021 (11:16:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0836.v1

Therapeutic Efficacy and Safety of Lenvatinib after Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma

Shigeki Yano, Tomokazu Kawaoka, Shintaro Yamasaki, Yusuke Johira, Masanari Kosaka, Yuki Shirane, Ryoichi Miura, Kei Amioka, Kensuke Naruto, Kenji Yamaoka, Yasutoshi Fujii, Shinsuke Uchikawa, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Daiki Miki, Masataka Tsuge, Yuji Teraoka, Hirotaka Kouno, Shintaro Takaki, Nami Mori, Keiji Tsuji, Shiro Oka

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatocellular carcinoma; unresectable; atezolizumab plus bevacizumab; lenvatinib

Online: 12 October 2023 (15:36:58 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202305.0563.v2

A Descriptive Analysis of Sleeve Gastrectomy in Japan Based on National Registry by Japanese Society for Treatment of Obesity

Shinichi Okazumi, Takashi Oshiro, Akira Sasaki, Hisahiro Matsubara, Ichiro Tatsuno

Subject: Arts And Humanities, Humanities Keywords: national registry; bariatric surgery; sleeve gastrectomy; safety; efficacy

Online: 19 June 2023 (07:36:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0185.v1

Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-enhanced MRI and Comparison with Histologic Collagen Content

Kiyohisa Kamimura, Masanori Nakajo, Manisha Bohara, Daigo Nagano, Yoshihiko Fukukura, Shingo Fujio, Tomoko Takajo, Kazuhiro Tabata, Takashi Iwanaga, Hiroshi Imai, Marcel Dominik Nickel, Takashi Yoshiura

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: pituitary adenoma; consistency; magnetic resonance imaging; pharmacokinetic analysis; collagen.

Online: 7 June 2021 (13:25:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0311.v1

A Dialogue System that Models User's Opinion Based on Information Content

Yoshiki Ohira, Takahisa Uchida, Takashi Minato, Hiroshi Ishiguro

Subject: Computer Science And Mathematics, Computer Science Keywords: opinion model; user modeling; information content; dialogue strategy; dialogue system

Online: 21 September 2022 (02:27:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202112.0514.v1

Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer

Yoichi Morofuji, Shinsuke Nakagawa, Kenta Ujifuku, Takashi Fujimoto, Kaishi Otsuka, Masami Niwa, Keisuke Tsutsumi

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: cancer; cerebrovascular diseases; cardiovascular diseases; pleiotropic effect; statin

Online: 31 December 2021 (11:36:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0642.v1

Characteristics of Abnormalities in Somatosensory Submodalities Observed in Residents Exposed to Methylmercury

Shigeru Takaoka, Tadashi Fujino, Shin-ichi Shigeoka, Takashi Yorifuji

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: methylmercury; long term exposure; symptoms; neurological findings; somatosensory submodalities; quantitative sensory examination; nerve conduction study

Online: 8 December 2023 (16:01:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1780.v1

Development of Cavitation Generator Mimicing Pistol Shrimp

Hitoshi Soyama, Mayu Tanaka, Takashi Takiguchi, Matsuo Yamamoto

Subject: Engineering, Mechanical Engineering Keywords: cavitation; cavitation generator; pistol shrimp; pulsed laser; pulsed water jet; piezo actuator

Online: 29 November 2023 (07:33:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0051.v1

The Character of Urban Japan: Overview of Osaka-Kobe’s Cityscapes

Joan Perez, Alessandro Araldi, Giovanni Fusco, Takashi Fuse

Subject: Social Sciences, Geography, Planning And Development Keywords: urban structure; urban form; urban fabric; Japan; Osaka

Online: 4 October 2019 (11:52:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0438.v1

Time-division Color Holographic Projection in Large Size Using a Digital Micromirror Device

Takayuki Takahashi, Tomoyoshi Shimobaba, Takashi Kakue, Tomoyoshi Ito

Subject: Physical Sciences, Acoustics Keywords: holography; hologram; computer-generated hologram; holographic projection; time-division; digital micromirror device

Online: 16 June 2021 (10:33:00 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202312.2024.v1

Tirzepatide and Glycemic Control Metrics Using Continuous Glucose Monitoring in Older Patients with Type 2 Diabetes Mellitus: An Observational Pilot Study

Takuya Omura, Akemi Inami, Taiki Sugimoto, Shuji Kawashima, Takashi Sakurai, Haruhiko Tokuda

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Tirzepatide; time in range; continuous glucose monitoring; elderly

Online: 27 December 2023 (07:49:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0222.v1

Sterepinic Acids A–C, New Carboxylic Acids Produced by a Marine Alga-Derived Fungus

Takeshi Yamada, Miwa Matsuda, Mayuko Seki, Megumi Hirose, Takashi Kikuchi

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: terepinic acids; Stereum sp.; marine microorganism; Undaria pinnatifida; vibralactones; phenylglycine methyl ester method

Online: 16 May 2018 (06:28:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0621.v1

In Vitro Evaluation of No-carrier-added Radiolabeled Cisplatin ([^{189, 191}Pt]cisplatin) Emitting Auger Electrons

Honoka Obata, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Katsuyuki Minegishi, Kotaro Nagatsu, Mikako Ogawa, Ming-Rong Zhang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Auger electron; cisplatin; 191Pt; 189Pt; radio-drug; DNA double-strand break; γH2AX

Online: 25 March 2021 (14:30:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0412.v1

Interval to Recurrence Affects Survival in Recurrent Head and Neck Squamous Cell Carcinoma

Mioko Matsuo, Kazuki Hashimoto, Ryunosuke Kogo, Masanobu Sato, Tomomi Manako, Takashi Nakagawa

Subject: Medicine And Pharmacology, Otolaryngology Keywords: squamous cell carcinoma; recurrence; radiotherapy

Online: 7 February 2024 (08:34:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0206.v1

Improved Gender Recognition during Stepping Activity for Rehab Application Using the Combinatorial Fusion Approach of EMG and HRV

Nor Aziyatul Izni Mohd Rosli, Mohd Azizi Abdul Rahman, Malarvili Balakrishnan, Takashi Komeda, Saiful Amri Mazlan, Hairi Zamzuri

Subject: Engineering, Control And Systems Engineering Keywords: signal processing; feature selection; feature fusion; data fusion; gender recognition; sensor fusion; heart rate variability (HRV), electromyography (EMG); stepper

Online: 28 March 2017 (02:38:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1884.v1

Fungal Diversity in the Inhovde Area, East Antarctica

Masaharu Tsuji, Takuya Kobayashi, Tatsuya Fujikawa

Subject: Environmental And Earth Sciences, Ecology Keywords: East Antarctica; fungal diversity; Inhovde area

Online: 24 July 2024 (11:35:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1386.v1

Over 5,000 h at 85 °C Thermal Stability of Encapsulated Carbon–based Multiporous–Layered–Electrode Perovskite Solar Cells

Ryuki Tsuji, Yuuma Nagano, Kota Oishi, Eiji Kobayashi, Seigo Ito

Subject: Engineering, Energy And Fuel Technology Keywords: carbon electrode; fully printable; thermal stability; long-term stability

Online: 21 May 2024 (11:57:09 CEST)

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The key to the practical application of organometal–halide–crystals perovskite solar cells (PSCs) is to achieve thermal stability through robust encapsulation. This paper presents a method to significantly extend the thermal stability lifetime of perovskite solar cells to over 5,000 h at 85 °C by demonstrating an optimal combination of encapsulation methods and perovskite composition for carbon–based multiporous–layered–electrode (MPLE)–PSCs. We fabricated the four types of MPLE-PSCs using two encapsulation structures (over– and side–sealing with thermoplastic resin films) and two perovskite compositions ((5–AVA)x(methylammonium (MA))1–xPbI3 and (formamidinium (FA))0.9Cs0.1PbI3), and analyzed the 85 ºC thermal stability followed by ISOS–D–2 protocol. Without encapsulation, FA0.9Cs0.1PbI3 exhibited higher thermal stability than (5–AVA)x(MA)1–xPbI3. However, encapsulation reversed the phenomenon (that of (5–AVA)x(MA)1–xPbI3 became stronger). The combination of (5–AVA)x(MA)1–xPbI3 perovskite absorber and over–sealing encapsulation effectively suppressed the thermal degradation, resulting in the PCE value at 91.2% of the initial value after 5,072 h. On the other hand, another combination (side–sealing on (5–AVA)x(MA)1–xPbI3, over– and side–sealing on FA0.9Cs0.1PbI3) resulted in decreased stability. The FA–based perovskite was decomposed for these degradation mechanisms by the condensation reaction between FA and carbon. For side–sealing, the space between the cell and the encapsulant was estimated to contain approximately 1,260,000 times more H2O than in over–sealing, which catalyzed the degradation of the perovskite crystal. Our results demonstrate that MA–based PSCs, which are generally considered to be thermally sensitive, can significantly extend their thermal stability after the proper encapsulation. Therefore, we emphasize that finding the appropriate combination of encapsulation technique and perovskite composition is quite important to achieve further device stability.

Preprint ARTICLE | doi:10.20944/preprints202407.1890.v1

Impaired Coordination of the Ciliary Movement in Patients with Chronic Rhinosinusitis with Nasal Polyps: The Role of Decreased Planar Cell Polarity Protein Expression

Sakura Hirokane, Tomohiro Kawasumi, Sachio Takeno, Yukako Okamoto, Seita Miyamoto, Rikuto Fujita, Chie Ishikawa, Takashi Oda, Yuichiro Horibe, Takashi Ishino, Takao Hamamoto, Tsutomu Ueda

Subject: Medicine And Pharmacology, Otolaryngology Keywords: paranasal sinus; chronic rhinosinusitis; CRS; nasal polyps; ciliated cell; mucociliary clearance; planar cell polarity; CPLANE complex proteins; WDPCP; FUZ

Online: 24 July 2024 (08:02:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0848.v1

Association of Plasma Claudin-5 with Age and Alzheimer Disease

Keisuke Tachibna, Ryuichi Hirayama, Naoyuki Sato, Kotaro Hattori, Takashi Kato, Hiroyuki Takeda, Masuo Kondoh

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: blood-brain barrier; claudin-5; tight junction; biomarker; dementia; Alzheimer disease

Online: 14 November 2023 (11:27:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0413.v1

Dependency of Charge-Discharge Rate on Lithium Reaction Distributions for a Commercial Lithium Coin Cell Visualized by Compton Scattering Imaging

Kosuke Suzuki, Ryo Kanai, Naruki Tsuji, Hisao Yamashige, Yuki Orikasa, Yoshiharu Uchimoto, Yoshiharu Sakurai, Hiroshi Sakurai

Subject: Engineering, Energy And Fuel Technology Keywords: lithium reaction distribution; in-operando measurement; Compton scattering imaging

Online: 23 August 2018 (11:31:45 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202303.0143.v1

Optimized Protocol for Preservation of Human Platelet Samples for Fluorometric Polyphosphate Quantification

Tomoyuki Kawase, Katsuya Suzuki, Masami Kamimura, Tomoharu Mochizuki, Takashi Ushiki

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: platelets; polyphosphate; preservation

Online: 8 March 2023 (03:04:37 CET)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202308.1196.v1

Intra-Arterial Contrast-Enhanced Ultrasonography Using Sonazoid for Hepatocellular Carcinoma: Case Reports

Kazue Shiozawa, Takahiro Murakami, Takashi Matsui, Ken Ito, Manabu Watanabe

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatocellular carcinoma; contrast-enhanced ultrasonography; intra-arterial contrast-enhanced ultrasonography; transarterial chemoembolization; extrahepatic metastasis; hepatocellular carcinoma rupture

Online: 16 August 2023 (10:48:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1713.v1

The Influence of Nicotine on Trophoblast-Derived Exosomes in a Mouse Model of Pathogenic Preeclampsia

Ayane Kubo, Keiichi Matsubara, Yuko Matsubara, Hirotomo Nakaoka, Takashi Sugiyama

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: preeclampsia; exosomes; nicotine; proteomics; bioinformatics

Online: 24 May 2023 (13:29:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0302.v1

Multi-institutional Retrospective Analysis of Carbon-ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix

Noriyuki Okonogi, Ken Ando, Kazutoshi Murata, Masaru Wakatsuki, Shin-ei Noda, Daisuke Irie, Hiroshi Tsuji, Makio Shozu, Tatsuya Ohno

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: carbon-ion radiotherapy; uterine cervical cancer; adenocarcinoma; long-term follow-up; cisplatin; concurrent chemoradiotherapy

Online: 12 April 2021 (12:51:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0344.v1

The Mental Health of Young Return Migrants with Ancestral Roots in Their Destination Country: A Cross-Sectional Study Focusing on the Ethnic Identities of Japanese-Brazilian High School Students Living in Japan

Eriko Fukui, Takashi Uchino, Masunari Onozaka, Takashi Kawashimo, Momoko Iwai, Youji Takubo, Akiko Maruyama, Sachio Miura, Ryo Sekizaki, Masafumi Mizuno, Naoyuki Katagiri, Naohisa Tsujino, Takahiro Nemoto

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ethnic identity; mental health; migrant; transcultural psychiatry; youth

Online: 18 August 2022 (10:58:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0132.v1

Pelvic Ring Fractures: A Biomechanical Comparison of Sacral and Lumbopelvic Fixation Techniques

Sudharshan Tripathi, Norihiro Nishida, Sophia Soehnlen, Amey Kelkar, Yogesh Kumaran, Toshihiro Seki, Takashi Sakai, Vijay K. Goel

Subject: Engineering, Bioengineering Keywords: Pelvic ring fractures; fracture displacement; sacroiliac joint; fixation techniques; finite element analysis

Online: 2 February 2024 (07:27:56 CET)

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Abstract Background Context Pelvic ring fractures are becoming more common in the aging population and can prove to be fatal, having mortality rates between 10% and 16%. Stabilization of these fractures is challenging and often require immediate internal fixation. Therefore, it is necessary to have a biomechanical understanding of the different fixation techniques for pelvic ring fractures. Methods A previously validated three-dimensional finite element model of the lumbar spine, pelvis, and femur was used for this study. A unilateral pelvic ring fracture was simulated by resecting the left side of the sacrum and pelvis. Five different fixation techniques were used to stabilize the fracture. A compressive follower load and pure moment was applied to compare different biomechanical parameters including range of motion (contralateral sacroiliac joint, L1-S1 segment, L5-S1 segment), and stresses (L5-S1 nucleus stresses, instrument stresses) between different fixation techniques. Results Transiliac -trans sacral screw fixation at S1 and S2 showed the highest stabilization for horizontal and vertical displacement at the sacral fracture site and reduction of contralateral sacroiliac joint for bending and flexion range of motion by 165% and 121%, respectively. DTSF (Double transiliac rod and screw fixation) model showed highest stabilization in horizontal displacement at the pubic rami fracture site, while the L5_PF_W_CC (L5-Ilium posterior screw fixation with cross connectors) and L5_PF_WO_CC ( L5-Ilium posterior screw fixation without cross connectors) showed higher rod stresses, reduced L1-S1 (approximately 28%), and L5-S1 (approximately 90%) range of motion. Conclusions Longer sacral screw fixations were superior in stabilizing sacral and contralateral sacroiliac joint range of motion. Lumbopelvic fixations displayed a higher degree of stabilization in the horizontal displacement compared to vertical displacement of pubic rami fracture, while also indicating the highest rod stresses. When determining the surgical approach for pelvic ring fractures, patient-specific factors should be accounted for to weigh the advantages and disadvantages for each technique.

Preprint ARTICLE | doi:10.20944/preprints202303.0392.v1

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia

Takashi Uchino, Ryo Okubo, Youji Takubo, Akiko Aoki, Izumi Wada, Naoki Hashimoto, Satoru Ikezawa, Takahiro Nemoto

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ACSo; cognitive function; depression; PDQ; psychosis; real-world functioning; schizophrenia; SFS; social functioning

Online: 22 March 2023 (06:36:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0532.v1

Ferromagnetic Fluctuations in the Heavily Overdoped Regime of Single-Layer High-TC Cuprate Superconductors

Tadashi Adachi, Koshi Kurashima, Takayuki Kawamata, Takashi Noji, Satoru Nakajima, Yoji Koike

Subject: Physical Sciences, Condensed Matter Physics Keywords: ferromagnetic fluctuation; Tl-2201 cuprate; La-214 cuprate; Bi-2201 cuprate; electrical resistivity; magnetization

Online: 10 July 2023 (04:10:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1236.v1

Dissecting the Impact of USP21 on Mouse Lipid Metabolism and Identifying Polymorphism-Associated Hypercholesterolemia in Outpatients

Sailakshmi Iyer, Naoko Hattori, Hiroshi Okuda, Takeya Nakagawa, Takahiro Maeda, Haruhiko Koseki, Takashi Ito

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: USP21; Fabp7; Nlrc5; hypercholesterolemia

Online: 20 November 2023 (09:29:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0389.v2

Measurement of Opportunity Cost of Travel Time for Predicting Future Residential Mobility Based on the Smart Card Data of Public Transportation

Takashi Nicholas Maeda, Junichiro Mori, Masanao Ochi, Tetsuo Sakimoto, Ichiro Sakata

Subject: Social Sciences, Geography, Planning And Development Keywords: human mobility; residential mobility; smart card; public transportation; opportunity cost of travel time

Online: 26 September 2018 (05:46:51 CEST)

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Working Paper ARTICLE

Effects of Exercise on the Oral Microbiota and Saliva of Patients With Non-Alcoholic Fatty Liver Disease

Fumihiko Uchida, Sechang Oh, Takashi Shida, Hideo Suzuki, Kenji Yamagata, Yuji Mizokami, Hiroki Bukawa, Junichi Shoda

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: periodontal disease; non-alcoholic fatty liver disease; exercise; clinical trial; oral microbiota; saliva components

Online: 14 January 2021 (13:13:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1524.v1

Coccomyxa Kj Components Enhance the Expression of Metallothioneins and Th17 Cytokines during Human T Cell Activation

Toshiro Seki, Shino Oshima, Satoko Komatsu, Soga Yamada, Hirofumi Kashiwagi, Yumiko Goto, Banri Tsuda, Akiko Kanno, Atsushi Yasuda, Hitoshi Kuno, Noriko Tsuji, Takashi Shiina, Yoshie Kametani

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Coccomyxa subellipsoidea KJ; metallothioneins; Th17 cytokines; T cell activation; immunoregulation; transcriptome analysis; peripheral blood mononuclear cells; inflammatory factors; toxic shock syndrome toxin-1; immune regulatory drugs

Online: 27 February 2024 (10:26:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0427.v1

Ethyl Loflazepate as a Treatment for Patients with Idiopathic and Psychogenic Taste Disorder

Hikaru Shirakawa, Ken-ichiro Sakata, Hiroyuki Hato, Jun Sato, Noritaka Ohga, Haruhisa Watanabe, Takashi Iori, Yutaka Yamazaki, Yoshimasa Kitagawa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: ethyl loflazepate; idiopathic taste disorder; psychogenic taste disorder

Online: 23 November 2021 (14:49:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0222.v1

Identification of CT Attenuation Values that Could be Predictive of Necrosis (N-CTav) in Hepatocellular Carcinoma Tumors after Lenvatinib Treatment and the Association between the N-CTav Occupancy Rate in the Tumor and Maintenance of Complete Response with Lenvatinib Treatment

Makoto Chuma, Hideki Yokoo, Atsushi Hiraoka, Kazuhiko Ueda, Takahiro Yokoyama, Kunihiko Tsuji, Noritomo Shimada, Haruki Uojima, Satoshi Kobayashi, Nobuhiro Hattori, Tomomi Okubo, Masanori Atsukawa, Toru Ishikawa, Koichi Takaguchi, Akemi Tsutsui, Hidenori Toyoda, Toshifumi Tada, Yoshinori Saito, Shunji Hirose, Takaaki Tanaka, Kazuhisa Takeda, Masako Otani, Zenjiro Sekikawa, Tsunamasa Watanabe, Hisashi Hidaka, Manabu Morimoto, Kazushi Numata, Tatehiro Kagawa, Michiie Sakamoto, Takashi Kumada, Shin Maeda

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatocellular carcinoma; lenvatinib; molecular targeted agents; complete response; CT value

Online: 18 February 2022 (04:05:18 CET)

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Purpose: To assess the utility of measurement of the computed tomography (CT) attenuation value (CTav) in predicting tumor necrosis in hepatocellular carcinoma (HCC) patients who achieve a complete response (CR), defined using modified Response Evaluation Criteria in Solid Tumors (mRECIST), after lenvatinib treatment. Method: We compared CTav in arterial phase CT images with postoperative histopathology in four patients who underwent HCC resection after lenvatinib treatment, to determine CTav thresholds indicative of histological necrosis (N-CTav). Next, we confirmed the accuracy of the determined N-CTav in 15 cases with histopathologically proven necrosis in surgical specimens. Furthermore, the percentage of the tumor with N-CTav, i.e. the N-CTav occupancy rate, assessed using Image J software in 30 tumors in 12 patients with CR out of 571 HCC patients treated with lenvatinib, and its correlation with local recurrence following CR were examined. Results: Receiver operating characteristic (ROC) curve analysis revealed an optimal cut-off value of CTav of 30.2 HU, with 90.0% specificity and 65.0% sensitivity in discriminating between pathologically identified necrosis and degeneration, with a CTav of less than 30.2 HU indicating necrosis after lenvatinib treatment (N30-CTav). Furthermore, the optimal cut-off value of 30.6% for the N30-CTav occupancy rate by ROC analysis was a significant indicator of local recurrence following CR with 76.9% specificity and sensitivity (area under the ROC curve; 0.939), with the CR group with high N30-CTav occupancy (>30.6%) after lenvatinib treatment showing significantly lower local recurrence (8.3% at 1 year) compared with the low (<30.6%) N30-CTav group (P<0.001, 61.5% at 1 year). Conclusion: The cut-off value of 30.2 HU for CTav (N30-CTav) might be appropriate for identifying post-lenvatinib necrosis in HCC, and an N30-CTav occupancy rate of >30.6% might be a　predictor of maintenance of CR. Use of these indicators have the potential to impact systemic chemotherapy for HCC.

Preprint ARTICLE | doi:10.20944/preprints202307.0184.v1

A Stope Mining Design with Consideration of Hanging Wall When Transitioning from Open Pit Mining to Underground Mining for Sepon Gold Mine Deposit, Laos

Seelae Phaisopha, Hideki Shimada, Takashi Sasaoka, Akihiro Hamanaka, Phanthoudeth Pongpanya, Seva Shorin, Khounma Senthavisouk

Subject: Engineering, Mining And Mineral Processing Keywords: open pit slope stability; finite element analysis; generalized Hoek-Brown criterion; underground stopping stability; surface subsidence

Online: 4 July 2023 (09:32:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0114.v1

Frequency-Shift of Quartz Crystal Microbalance Depends on the Length of Actin Filaments

Naoki Matsumoto, Honoka Kobayashi, Taiki Nishimura, Hideki Ashizawa, Takashi Kuwahara, Hajime Honda, Ikuko Fujiwara

Subject: Engineering, Bioengineering Keywords: quartz crystal microbalance; actin; positive frequency shift; physical property; biomolecule

Online: 3 May 2023 (08:14:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0690.v1

Reliability and Validity of the Center for Epidemiologic Studies Depression (Ces-D) Scale for Adolescents in Lao Pdr

Sachi Tomokawa, Takashi Asakura, Ngouay Keosada, Vannasouk Bouasangthong, Vanthala Souvanhxay, Kethsana Kanyasan, Kimihiro Miyake, Sithane Soukhavong, Khamseng Thalangsy, Kazuhiko Moji

Subject: Social Sciences, Behavior Sciences Keywords: adolescents; depression; Laos; psychometric testing

Online: 29 July 2020 (10:37:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0384.v1

Automatic Acne Object Detection and Acne Severity Grading Using Smartphone Images and Artificial Intelligence

Quan Thanh Huynh, Phuc Hoang Nguyen, Hieu Xuan Le, Lua Thi Ngo, Nhu-Thuy Trinh, Mai Thi-Thanh Tran, Hoan Tam Nguyen, Nga Thi Vu, Anh Tam Nguyen, Kazuma Suda, Kazuhiro Tsuji, Tsuyoshi Ishii, Trung Xuan Ngo, Hoan Thanh Ngo

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Deep Learning; Smartphone Image; Acne Grading; Acne Object DetectionDeep Learning, Smartphone Image, Acne Grading, Acne Object Detection

Online: 28 June 2022 (10:05:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0171.v1

The Process to Plaque Rupture: The Role of Vasa Vasorum and Medial Smooth Muscle Contraction Monitored by Cardio-Ankle Vascular Index

Kohji Shirai, Takashi Hitsumoto, Shuji Sato, Mao Takahashi, Atsuhito Saiki, Daiji Nagayama, Masahiro Ohira, Akira Takahara, Kazuhiro Shimizu

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: cholesterol oxidative products; atheromatous lesion; plaque rupture; vasa vasorum; cardio-ankle vascular index

Online: 5 October 2023 (14:33:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0290.v1

N-Terminal (1→3)-β-D-glucan Recognition Proteins from Insects Recognize the Difference in ultra-Structures of (1→3)-β-D-glucan

Yoshiyuki Adachi, Masaki Ishii, Takashi Kanno, Junko Tetsui, Ken-ichi Ishibashi, Daisuke Yamanaka, Noriko Miura, Naohito Ohno

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: β-D-glucan; glucan binding protein; host defense; innate immunity

Online: 24 May 2019 (08:56:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0336.v1

Prevalence of Carnitine Deficiency and Decreased Carnitine Levels in Patients on Peritoneal Dialysis

Satoshi Shimizu, Hiroyuki Takashima, Ritsukou Tei, Tetsuya Furukawa, Makiyo Okamura, Maki Kitai, Chinami Nagura, Takashi Maruyama, Terumi Higuchi, Masanori Abe

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: carnitine; peritoneal dialysis; hemodialysis

Online: 30 September 2019 (03:21:27 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202303.0459.v1

Emergency Endoscopic Haemostasis for Gastrointestinal Bleeding using A Self-Assembling Peptide: A Case Series

Takashi Murakami, Eiji Kamba, Keiichi Haga, Yoichi Akazawa, Hiroya Ueyama, Tomoyoshi Shibuya, Mariko Hojo, Akihito Nagahara

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: endoscopic hemostasis; emergency endoscopy; gastrointestinal bleeding; self-assembling peptide

Online: 27 March 2023 (10:42:18 CEST)

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Working Paper CASE REPORT

Anti-diarrheal Effects of Wood Creosote, Seirogan, in Japanese Patients: A Retrospective Study

Masanori Takagi, Masafumi Ito, Hirofumi Morino, Takanori Miura, Kyoichi Oshida, Mayu Suzuki, Hiroshi Takemori, Takashi Shibata

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: diarrhea; wood creosote; Seirogan; retrospective study; capsule

Online: 16 October 2019 (09:35:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0296.v1

Pharmacotherapy for Advanced Non-Small Cell Lung Cancer with Performance Status 2 without Druggable Gene Alterations: Could Immune Checkpoint Inhibitors be a Game Changer?

Satoshi Ikeda, Tateaki Naito, Satoru Miura, Kentaro Ito, Naoki Furuya, Toshihiro Misumi, Takashi Ogura, Terufumi Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: non-small-cell lung cancer; performance status; cytotoxic chemotherapy; immune checkpoint inhibitor; cancer cachexia

Online: 20 September 2022 (05:53:12 CEST)

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Working Paper COMMUNICATION

Water Resistance of Torrefied Wood Pellets Prepared by Two Methods

Takahiro Yoshida, Katsushi Kuroda, Daisuke Kamikawa, Yoshitaka Kubojima, Takashi Nomura, Hiroki Watada, Tetsuya Sano, Seiji Ohara

Subject: Chemistry And Materials Science, Paper, Wood And Textiles Keywords: wood pellet; torrefaction; hydrophobicity; water resistance

Online: 5 October 2020 (16:39:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0090.v1

Preclinical Study of DNA-Recognized Peptide Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in Common Marmoset

Masari Otsuki, Noboru Fukuda, Takashi Inoue, Takayuki Mineshige, Tomoyasu Otsuki, Shu Horikoshi , Morito Endo, Masanori Abe

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: human; TGF-β1; pyrrole-imidazole polyamide; renal disease; marmoset

Online: 7 August 2019 (09:42:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0449.v1

Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy

Takao Hamamoto, Kazuki Sato, Kohei Yumii, Nobuyuki Chikuie, Takayuki Taruya, Yuichiro Horibe, Takashi Ishino, Tsutomu Ueda, Sachio Takeno, Kenichi Yoshimura

Subject: Medicine And Pharmacology, Otolaryngology Keywords: head and neck neoplasms; electric stimulation; chemoradiotherapy; swallowing; dysphagia

Online: 6 June 2023 (11:37:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1767.v1

Usefulness of Tumor Marker Score for Prediction of Prognosis in Hepatocellular Carcinoma Patients Treated with Atezolizumab plus Bevacizumab: A Multicenter Retrospective Study

Kazunari Tanaka, Kunihiko Tsuji, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hidekatsu Kuroda, Yutaka Yata, Hideko Ohama, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Keisuke Yokohama, Hiroki Nishikawa, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Takashi Kumada

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; tumor marker; atezolizumab plus bevacizumab; prognosis; predictive model

Online: 26 June 2023 (09:42:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1836.v3

The Combination of Binding-Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcome of Oral Food Challenge during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy

Shoichiro Taniuchi, Rika Sakai, Takashi Nishida, Meguru Goma, Masatoshi Mitomori, Aya Imaide, Masahiro Enomoto, Masamitsu Nishino, Yo Okizuka, Hiroshi Kido

Subject: Biology And Life Sciences, Food Science And Technology Keywords: oral immunotherapy; hen’s egg allergy; IgE binding-avidity; ovomucoid specific IgE; ovomucoid specific IgG4; oral food challenge

Online: 31 May 2023 (02:28:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0316.v1

Temporal Trend of the SARS-CoV-2 Omicron Variant and Res-Piratory Syncytial Virus in the Nasal Cavity and Accuracy of the Newly Developed Antigen-Detecting Rapid Diagnostic Test

Daisuke Tamura, Yuji Morisawa, Takashi Mato, Shin Nunomiya, Masaki Yoshihiro, Yuta Maehara, Shizuka Ito, Yasushi Ochiai, Hirokazu Yamagishi, Toshihiro Tajima, Takanori Yamagata, Hitoshi Osaka

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Omicron; rapid diagnostic test; RT-PCR; RSV; SARS-CoV-2; viral antigens

Online: 6 December 2023 (07:38:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1597.v1

Provision of Palliative Care for Patients with Advanced Dementia across Various Long-Term Care Settings in Japan: A Questionnaire-Based Survey

Yoshihisa Hirakawa, Ayane Komatsu, Tami Saito, Takashi Yamanaka, Satoshi Hirahara, Jiro Okochi, Masafumi Kuzuya, Hisayuki Miura

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: dementia; long-term care facility; home nursing care; family involvement; palliative care; spiritual care

Online: 23 January 2024 (04:57:24 CET)

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