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Preprint ARTICLE | doi:10.20944/preprints202404.1693.v1

Promotion Effect of H2S with High Concentrations on Catalytic Dry Reforming of Methane in Sour Natural Gas

Hengchang Ni, Xiaoyu Jia, Li Yu, Yuyang Li, Ping Li

Subject: Engineering, Energy And Fuel Technology Keywords: Sour natural gas; Dry reforming of methane; High H2S concentration; Promotion effect; MgO-based catalyst; S-adsorbed species

Online: 25 April 2024 (16:03:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0072.v1

Corrosion of Fe-(9~37) wt.%Cr Alloys at 700-800 ^oC in (N₂, H₂O, H₂S)-Mixed Gas

Min Jung Kim, Muhammad Ali Abro, Yuke Shi, Dong Bok Lee

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Fe-Cr alloy; oxidation; sulfidation; H2S corrosion

Online: 18 October 2016 (08:04:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0239.v1

Mitigating Large Language Model Bias: Automated Dataset Augmentation and Prejudice Quantification

Devam Mondal, Carlo Lipizzi

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: natural language processing; large language models; dataset augmentation; computational social science

Online: 6 May 2024 (07:24:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0549.v1

Advanced Quantification of Receptor–Ligand Interaction Lifetimes via Single-Molecule FRET Microscopy

Lukas Schrangl, Vanessa Mühlgrabner, René Platzer, Florian Kellner, Josephine Wieland, Reinhard Obst, Jose L. Toca-Herrera, Johannes B. Huppa, Gerhard J. Schütz, Janett Göhring

Subject: Biology And Life Sciences, Biophysics Keywords: single-molecule FRET; single-molecule microscopy; receptor-ligand interaction; T cell receptor; bond lifetime quantification; T cell activation; antigen sensitivity; simulation; survival analysis

Online: 9 July 2024 (03:56:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1263.v1

Metabolic and Functional Interaction of H₂S and Sucrose in Maize Thermotolerance through Redox Homeodynamics

Xiao-Er Li, Hong-Dan Zhou, Zhong-Guang Li

Subject: Biology And Life Sciences, Plant Sciences Keywords: Hydrogen sulfide; maize seedlings; redox homeodynamics; sucrose signaling; thermotoleranceugh MG-scavenging system; Calcium; Maize seedling; Methylglyoxal; Methylglyoxal-scavenging system; Thermotolerance

Online: 20 May 2024 (09:51:30 CEST)

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Working Paper ARTICLE

Exogenous H2S Regulates the Expression of Cystathionine Gamma-Lyase in HUVECs During Hypoxia

Maoxian Wang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cystathionine gamma-lyase; Hydrogen sulfide; Hypoxia; HUVECs

Online: 23 June 2021 (11:51:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2136.v1

Quantification of Methane Hydration Energy Through Free Energy Perturbation Method

Faranak Hatami, Mousa Moradi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Solvation free energies; Free Energy Perturbation; hydration; Molecular dynamics; LAMMPS

Online: 26 July 2024 (06:37:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2140.v1

Single−molecule Level Quantification Reveals the Interaction between Melittin and Lipopolysaccharide by Atomic Force Microscopy

Sheng Huang, Guoqi Su, Li Yang, Liangguang Yue, Li Chen, Jinxiu Huang, Feiyun Yang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: melittin; lipopolysaccharide; atomic force microscopy; interaction force; kinetics characteristics

Online: 30 August 2024 (03:37:03 CEST)

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The interaction forces and mechanical properties of the interaction between melittin (Mel) and lipopolysaccharide (LPS) are considered a crucial driving force for Mel in killing Gram−negative bacteria (GNB). However, how their interaction forces are performed at the single−molecule level and the dissociation kinetic characteristics of the Mel/LPS complex remain poorly understood. In this study, the single−molecule level interaction forces between Mel and LPSs from E. coil K−12, O55:B5, O111:B4, and O128:B12 were explored using atomic force microscopy (AFM) based single−molecule force spectroscopy (SMFS). Further, the AFM−based dynamic force spectroscopy (DFS) and advanced analytical model were employed to investigate the kinetic characteristics of the Mel/LPSs complex dissociation. The results indicated that Mel could interact with both rough (R)−form LPS (E. coli K−12) and smooth (S)−form LPSs (E. coli O55:B5, O111:B4, O128:B12), and the S−form LPSs showed a more robust interaction with Mel than R−form LPS, and a slight difference existed in the interaction forces between Mel and diverse S−form LPSs. The Mel interacts with S−form LPSs showed greater specific and non−specific interaction forces than R−form LPS (p < 0.05), as determined by AFM−based SMFS. However, there was no significant difference in the specific and non−specific interaction forces among the three S−form LPSs (p > 0.05), indicating the variability of O−antigen could not affect the interaction between Mel and LPSs. The DFS result showed that the Mel/S−form LPSs complexes had a lower dissociation rate constant (koff), a shorter energy barrier width (xβ), a longer bond lifetime (τoff), and a higher height of the energy barrier (∆G), demonstrating that Mel could interact with S−form LPSs to form more stable complexes. In conclusion, this study promotes our knowledge of the interaction micromechanics and kinetics characteristics between Mel and LPS at the single−molecule level. Moreover, it can help us design and evaluate new anti−GNB drugs.

Preprint ARTICLE | doi:10.20944/preprints202312.0233.v1

Hydrogen Sulfide (H₂S) Adsorption from Natural Gas Using Silver Modified 13X Molecular Sieve

Mirzokhid Abdirakhimov, Mohsen H. Al-Rashed, Janusz Wójcik

Subject: Engineering, Chemical Engineering Keywords: H₂S adsorption; 13X molecular sieve; adsorption capacity; ion exchange; silver modification

Online: 5 December 2023 (15:10:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1438.v1

Convolutional Neural Networks Applied to Antimony Quantification via Reflectance Spectroscopy Using Soils from Northern Portugal: Opportunities and Challenges

Morgana Carvalho, Joana Cardoso-Fernandes, Alexandre Lima, Ana Caudia Teodoro

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Antimony; exploration; reflectance spectroscopy; soil analysis; critical raw materials; deep learning; geology

Online: 26 February 2024 (11:43:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0308.v1

H2S Removal via Sorption Process on Activated Carbon-Metal Oxide Composites Derived from Different Biomass Sources

Maria Baikousi, Anna Gantzoudi, Christina Gioti, Dimitrios Moschovas, Aris E. Giannakas, Apostolos Avgeropoulos, Constantinos E. Salmas, Michael A. Karakassides

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: activated carbon; biomass; carbon composites; spent coffee; Aloe-Vera; corncob; zinc oxide, H2S, hydrogen sulfide, adsorption

Online: 6 October 2023 (05:05:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0085.v2

Experimental Investigation of Impact Detection and Damage Extent Quantification

Mohammad Faisal Haider, Asaad Migot, Md Yeasin Bhuiyan, Victor Giurgiutiu

Subject: Engineering, Mechanical Engineering Keywords: impact localization; composite materials; PPS; imaging method; immersion ultrasonic scanning

Online: 7 August 2018 (08:53:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0142.v1

On the Quantification of Relativistic Trajectories

Jean-Pascal Laedermann

Subject: Physical Sciences, Mathematical Physics Keywords: General relativity; geodesics; digitization; quantization; Schwarzschild; Kruskal-Szekeres; singularity; Lambert; tachyon; arbitrary precision calculation; complex time; Lorentz boost

Online: 8 December 2021 (14:49:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0089.v1

Deterministic Modeling and Uncertainty Quantification of Wind Waves in Ilha Solteira dam Reservoir, Brazil

Germano de Oliveira Mattosinho, Fabiana de Oliveira Ferreira, Geraldo de Freitas Maciel

Subject: Engineering, Civil Engineering Keywords: Wave modeling; Wind waves; SWAN model; Metamodeling; Sobol’ s index; Uncertainty quantification

Online: 2 May 2024 (12:04:08 CEST)

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Working Paper ARTICLE

Comparative Proteomic Analysis Reveals the Regulatory Effects of H₂S on Salt Tolerance of Mangrove Plant Kandelia obovata

Yi-ling Liu, Zhi-jun Shen, Martin Simon, Huan Li, Dong-na Ma, Xue-yi Zhu, Hai-lei Zheng

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Kandelia obovata; mangrove; hydrogen sulfide; salt tolerance; comparative proteome

Online: 24 November 2019 (14:25:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0762.v3

Uncertainty Quantification And Sensitivity Analysis Of Parameterization-free Surrogate Model

Jiajun Cao, Qingbiao Li, Liping Xu, Rui Yang, Yuejin Dai

Subject: Engineering, Mechanical Engineering Keywords: uncertainty quantification; sensitivity analysis; surrogate model method; optimisation; graph neural network; parameterisation

Online: 24 January 2022 (10:39:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0152.v1

Thermography Quantification of Human Perfusion Thermal Signature

Abbas K. AlZubaidi, Ahmed F. Hussein, Mena Basil, Qais Ahmed Habash

Subject: Engineering, Other Keywords: infrared thermography; blood perfusion signal; thermal excitation; bioheat transfer; Pennes equation; active thermography imaging

Online: 8 August 2018 (03:28:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0791.v1

On the Use of a Zn/Mn-Based Material as Adsorbent at Room Temperature for Harmful H₂S Gas

Francisco José Alguacil, Manuel Alonso, José Ignacio Robla, Félix Antonio López

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: hydrogen sulphide; adsorption; fixed-bed column; modelling; spent alkaline batteries; Zn-Mn-oxides mixture

Online: 9 August 2023 (16:23:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0352.v1

Visualization and Quantification of Facemask Leakage Flows and Interpersonal Transmission with Varying Face Coverings

Xiuhua Si, Jensen S. Xi, Mohamed Talaat, Jay Hoon Park, Ramaswamy Nagarajan, Michael Rein, Jinxiang Xi

Subject: Engineering, Bioengineering Keywords: face covering; mask fit; leakage flows; Schlieren optical imaging system; interpersonal transmission; self-inoculation; short-range airborne transmission; double masking

Online: 7 June 2024 (11:44:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0523.v1

Proteomics-based Methodologies for the Detection and Quantification of Seafood Allergens

Mónica Carrera, Manuel Pazos, María Gasset

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: discovery proteomics; targeted proteomics; mass spectrometry; fish allergens; crustacean allergens; mollusk allergens

Online: 22 July 2020 (11:23:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0159.v1

On the Applicability of Electrophoresis for Protein Quantification

Karina Dome, Zoya Akimenko, Aleksey Bychkov, Yuri Kalambet, Oleg Lomovsky

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: electrophoresis; protein; mechanical treatment; quantification

Online: 6 July 2021 (14:54:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0104.v1

Can Biochar Save Lives? The Impact of Surficial Biochar Treatment on Acute H₂S and NH₃ Emissions During Swine Manure Agitation Before Pump-out

Baitong Chen, Jacek A. Koziel, Myeongseong Lee, Hantian Ma, Zhanibek Meiirkhanuly, Peiyang Li, Andrzej Białowiec, Robert C. Brown

Subject: Environmental And Earth Sciences, Environmental Science Keywords: biochar; hydrogen sulfide; ammonia; livestock manure; agricultural safety; deep pit storage; waste management; air pollution; odor

Online: 7 June 2020 (15:54:48 CEST)

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Hydrogen sulfide and ammonia are always a concern in the livestock industries, especially when farmers try to clear their manure storage pits. Agitation of manure can cause dangerously high concentrations of harmful agents such as H₂S and NH₃ to be emitted into the air. Biochar has the ability to sorb these gases. We hypothesized that applying biochar on top of manure can create an effective barrier to protect farmers and animals from exposure to NH₃ and H₂S. In this study, two kinds of biochar were tested, highly alkaline, and porous (HAP, pH 9.2) biochar made from corn stover and red oak biochar (RO, pH 7.5). Two scenarios of (6 mm) 0.25” and (12 mm) 0.5” thick layers of biochar treatments were topically applied to the manure and tested on a pilot-scale setup, simulating a deep pit storage. Each setup experienced 3-min of agitation using a transfer pump, and measurements of the concentrations of NH₃ and H₂S were taken in real-time and measured until the concentration stabilized after the sharp increase in concentration due to agitation. The results were compared with the control in the following 3 situations: 1. The maximum (peak) flux 2. Total emission from the start of agitation until the concentration stabilized, and 3. The total emission during the 3 min of agitation. For NH₃, 0.5” HAP biochar treatment significantly (p<0.05) reduced maximum flux by 63.3%, overall total emission by 70%, and total emissions during the 3-min agitation by 85.2%; 0.25” HAP biochar treatment significantly (p<0.05) reduced maximum flux by 75.7%, overall, total emission by 74.5%, and total emissions during the 3-min agitation by 77.8%. 0.5” RO biochar treatment significantly reduced max by 8.8%, overall total emission by 52.9%, and total emission during 3-min agitation by 56.8%; 0.25” RO biochar treatment significantly reduced max by 61.3%, overall total emission by 86.1%, and total emission during 3-min agitation by 62.7%. For H₂S, 0.5” HAP biochar treatment reduced the max by 42.5% (p=0.125), overall total emission by 17.9% (p=0.290), and significantly reduced the total emission during 3-min agitation by 70.4%; 0.25” HAP treatment reduced max by 60.6% (p=0.058), and significantly reduced overall and 3-min agitation’s total emission by 64.4% and 66.6%, respectively. 0.5” RO biochar treatment reduce the max flux by 23.6% (p=0.145), and significantly reduced overall and 3-min total emission by 39.3% and 62.4%, respectively; 0.25” RO treatment significantly reduced the max flux by 63%, overall total emission by 84.7%, and total emission during 3-min agitation by 67.4%.

Preprint ARTICLE | doi:10.20944/preprints202402.1274.v1

Monthly Hydraulic Geometry Relationship Quantification With Environmental LAI by Utilizing Sentinel Data: A Case in Jingjiang Reach of the Yangtze River

Hai Huang, Xiaolong Song, Haijue Xu, Yuchuan Bai

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Hydraulic geometry relationship; Leaf area index; Ordinary differential equations; Channel stability; Jingjiang reach of the Yangtze River

Online: 22 February 2024 (07:54:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1973.v1

Advanced Disease Monitoring and Severity Quantification for Greenhouse Management Using Multispectral Imaging

Shafaq Khan, Munir Majdalawieh, Boubakeur Boufama, Yajan Sharma, Ashwitha Basani

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: convolutional neural network (CNN); generative adversarial networks (GANs); gaussian mixture model (GMM); grapevine vein-clearing virus (GVCV); hyperspectral imaging (HSI); normalized difference vegetation index (NDVI); normalized difference water index (NDWI); principal component analysis (PCA); region of interest (ROI); simulated hyperspectral images (SHSI); visual geometry group (VGG-16)

Online: 29 January 2024 (08:41:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0288.v1

Narrow Precursor Mass Range for DIA-MS Enhances Protein Identification and Quantification

Huoming Zhang, Dalila Bensaddek

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: data-independent acquisition (DIA); mass spectrometry, precursor mass range selection, Arabidopsis; quantitative proteomics.

Online: 13 July 2021 (10:06:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0468.v1

Quantification of Atmospheric Ammonia Concentrations: A Review of its Measurement and Modeling

Arshad Arjunan Nair, Fangqun Yu

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: review; ammonia; modeling; measurement; atmospheric chemistry; particle formation and PM2.5

Online: 21 August 2020 (04:06:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0542.v1

Development of an HPLC Method through the QbD Approach for the Quantification of Honokiol and Metformin Hydrochloride – Method Validation and Pharmaceutical Applications on Oral Dosage Forms

Mousa Sha’at, Adrian Florin Spac, Iulian Stoleriu, Alexandra Bujor, Monica Stamate Cretan, Mihaela Hartan, Lăcrămioara Ochiuz

Subject: Medicine And Pharmacology, Pharmacy Keywords: QbD optimization; HPLC; validation; greenness; assay; dissolution test; metformin hydrochloride; honokiol; oral dosage forms; diabetes mellitus.

Online: 9 July 2024 (06:08:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1663.v2

Colorimetric Quantification for Residual Poly- DADMAC in Water Treatment

Ilil Levakov, Ido Maor, Chen Barak, Yael Kirshenbaum, Giora Rytwo

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Cationic polyelectrolyte coagulant; fast green; spectrophotometric quantification; water treatment

Online: 20 September 2023 (09:55:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0034.v1

Simultaneous Quantification of 16 Bisphenol Analogues in Food Matrices

Fiorella Lucarini, Rocco Gasco, Davide Staedler

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: bisphenol analogues; canned foods; food matrices; QuEChERS; GC-MS; LC-MS/MS; endocrine disruptors

Online: 3 July 2023 (09:35:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0600.v1

Quantification on Non-Motor Symptoms in Parkinsonian Cynomolgus Monkeys

Yu Bao, Chaoning Gan, Zuyue Chen, Zhongquan Qi, Zhiqiang Meng, Feng Yue

Subject: Biology And Life Sciences, Aging Keywords: Parkinson; monkey; non-motor symptoms; anxiety; sleep; cognition

Online: 8 June 2023 (07:25:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0231.v1

Thyroxine Quantification by Using Plasmonic Nanoparticles As SERS Substrates

Paulina De Leon Portilla, Ana Lilia González, Enrique Sanchez-Mora

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Ag; Au; Nanoparticles; SERS; thyroxine; DDA; Sensor

Online: 5 June 2023 (04:09:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0073.v1

Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion

Bryan Misiewicz, Adam L. VanWert

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: oxalate; oxalic acid

Online: 6 September 2022 (02:43:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0199.v1

Strain Ratio as a Quantification Tool in Strain Imaging

Roald Flesland Havre, Jo Erling Riise Waage, Anesa Mulabecirovic, Odd Helge Gilja, Lars Birger Nesje

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: ultrasound; strain elastography; quantification; strain ratio; strain quantification; measurement variability; pancreas; EUS; Crohn’s disease; carcinoma

Online: 16 April 2018 (08:56:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0308.v1

Irradiance Variability Quantification and Small-Scale Averaging in Space and Time: A Short Review

Gerald M. Lohmann

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: irradiance variability, high-resolution measurements, increment statistics

Online: 19 June 2018 (17:10:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2064.v1

TaqMan qPCR Detection and Quantification of Phytophthora cinnamomi in Soil and Plant Tissues for Walnut Disease Management

Anita Haegi, Laura Luongo, Salvatore Vitale, Lorenza Tizzani, Alessandra Belisario

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: real-time PCR; tree decline; diagnostic; early detection; soil detection

Online: 30 May 2024 (13:47:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1495.v1

Uncertainty Quantification Based on Residual Tsallis Entropy of Order Statistics

Mansour Shrahili, Mohamed Kayid

Subject: Engineering, Civil Engineering Keywords: order statistics; residual Tsallis entropy; Shannon entropy; residual lifetime; (n-i+1)-out-of-n system

Online: 22 September 2023 (11:09:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0358.v1

Data-Informed Decomposition for Localized Uncertainty Quantification of Dynamical Systems

Waad Subber, Sayan Ghosh, Piyush Pandita, Yiming Zhang, Liping Wang

Subject: Engineering, Control And Systems Engineering Keywords: Bayesian inference; uncertainty quantification; dynamical systems; inverse problem; system identification; Gaussian process regression; polynomial chaos

Online: 17 August 2020 (10:15:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0615.v1

Numerical Comparisons Between Bayesian and Frequentist Low-Rank Matrix Completion: Estimation Accuracy and Uncertainty Quantification

The Tien Mai

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Low-rank matrix; matrix completion; Bayesian method; de-biased estimator; uncertainty quantification; confidence interval

Online: 22 April 2021 (14:58:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0025.v1

Curcumin and Quercetin Loaded Nanoemulsion: Physicochemical Compatibility Study and Validation of a Simultaneous Quantification Method

Gustavo Vaz, Adryana Clementino, Juliana Bidone, Marcos Villetti, Mariana Falkembach, Matheus Batista, Paula Barros, Cristiana Dora, Fabio Sonvico

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: HPLC method; Curcumin; Quercetin; Thermal analysis; Nanoemulsion

Online: 2 August 2020 (12:15:13 CEST)

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Biphasic oily/water nanoemulsions have been proposed as delivery systems for the intranasal administration of curcumin (CUR) and quercetin (QU), due to their high drug entrapment efficiency, the possibility of simultaneous drug administration and protection of the encapsulated compounds from the degradation. To better understand the physicochemical and biological performance of the selected formulation simultaneously co-encapsulating CUR and QU, a stability test of the compounds mixture was firstly carried out using X-ray powder diffraction and thermal analyses, such as differential scanning calorimetry (DSC) and thermogravimetric analyses (TGA). The determination and quantification of the encapsulated active compounds was then required being an essential tool for the development of innovative nanomedicines. Thus, a new HPLC–UV/Vis method for the simultaneous determination of CUR and QU in the nanoemulsions and their evaluation in stability studies in simulated biological fluids was developed and validated. The X-ray diffraction analyses demonstrated that no interaction between the mixture of active ingredients, if any, is strong enough to take place in the solid state. Moreover, the thermal analysis demonstrated that the CUR and QU are stable in the nanoemulsion production temperature range. The proposed analytical method for the simultaneous quantification of the two actives was selective and linear for both compounds in the range of 0.5 – 12.5 µg/mL (R2 > 0.9997), precise (RSD below 3%), robust and accurate (recovery 100 ± 5 %). The method was validated in accordance with ICH Q2 R1 “Validation of Analytical Procedures” and CDER-FDA 2validation of chromatographic methods” guideline. Furthermore, the low detection (LOD < 0.005 µg/mL for CUR and <0.14 µg/mL for QU) and quantification limits (LOQ < 0.017 µg/mL for CUR and < 0.48 µg/mL for QU) of the method were suitable for the application to drug release and permeation studies planned for the development of the nanoemulsions. The method was then applied for the determination of nanoemulsions CUR and QU encapsulation efficiencies (> 99%), as well as for the stability studies of the two compounds in simulated biological fluids over time. The proposed method represents, to our knowledge, the only method for the simultaneous quantification of CUR, and QU in nanoemulsions.

Preprint ARTICLE | doi:10.20944/preprints202402.1415.v1

Carbonization Activity in the Rural Area of Lubumbashi (DR Congo): Quantification and Yield Determinants

Nathan Mukendi Kasanda, Khoji Muteya Héritier, Dieu-donné Nghonda N'tambwe, Fabio Berti, Yannick Useni Sikuzani, Laurent Ndjibu Ngoy, Jean-Paul Mbay Katond, Jules Mwine Fyama Nkulu, Philippe Lebailly, Jan BOGAERT

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Pyrolysis; Deforestation; Charcoal; Miombo woodland; Environment

Online: 26 February 2024 (11:50:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1869.v1

Auto-Segmentation and Quantification of Non-cavitated Enamel Caries Imaged with Swept Source OCT

Tamer Abdelrehim, Maha Salah, Alex Fok, Heather J Conrad, Hooi Pin Chew

Subject: Engineering, Bioengineering Keywords: OCT; Micro CT; SEM; Image Segmentation; Carious; batch-processing; Simulation; Dental imaging; demineralization; Quantification

Online: 30 October 2023 (08:38:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1578.v1

Prevalence and Quantification of the Effects of Sexual Harassment Victimization of School-Aged Adolescents

Verónica Marcos, Dolores Seijo, Álvaro Montes, Ramón Arce

Subject: Social Sciences, Psychology Keywords: Internalizing Mental Health Problems; Externalizing Mental Health Problems Adolescence; Educational setting; Violence prevention; Gender issues

Online: 22 September 2023 (13:15:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0477.v1

Quantification of Microplastics in North-Western Mediterranean Harbors: Seasonality and Biofilm-related Metallic Contaminants

Javier A. Tesán Onrubia, Kahina Djaoudi, Franco Borgogno, Susana Canuto, Bernard Angeletti, Giovanni Besio, Marco Capello, Laura Cutroneo, Alessandro Stocchino, Stéphane Mounier, Véronique Lenoble

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Microplastic; harbor; trace metal; Mediterranean Sea; biofilm; bioconcentration

Online: 25 January 2021 (10:46:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1414.v1

Quantification of Airborne Particulate Matter and Trace Elements Deposition on Hedera helix and Senecio cineraria Leaves

Anabel Saran, Mariano Javier Mendez, Diego Gabriel Much, Valeria Imperato, Sofie Thijs, Jaco Vangronsveld, Luciano Jose Merini

Subject: Environmental And Earth Sciences, Pollution Keywords: particulate matter; air pollution; trace elements; bio-monitors; plants

Online: 17 July 2024 (10:52:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0193.v1

Coumarins in Spirit Beverages: Sources, Quantification, and Their Involvement in the Quality, Authenticity and Food Safety

Sheila Oliveira-Alves, Sílvia Lourenço, Tiago A. Fernandes, Sara Canas

Subject: Chemistry And Materials Science, Food Chemistry Keywords: coumarins; wine spirit; brandy; grape marc spirit; whiskey; rum; cachaç; a; ageing; nutraceuticals; authenticity; food safety

Online: 3 January 2024 (09:44:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0581.v1

Looking into the Quantification of Forensic Samples with Real-Time PCR

Ugo Ricci, Dario Ciappi, Ilaria Carboni, Claudia Centrone, Irene Giotti, Martina Petti, Alice Brogi, Elisabetta Pelo

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: DNA amplification; polymerase chain reaction; DNA quantification; forensic DNA

Online: 9 May 2024 (10:39:14 CEST)

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The quantification of human DNA extracts from forensic samples plays a key role in the forensic genetics process. Quantification guarantees maximum efficiency and avoids repeated analyses, over amplified samples, or unnecessary examinations. Here, we present our experience using an extremely sensitive real-time-based method with the Quantifiler® Trio DNA quantification kit, which we have explored in the ISO/IEC17025 accredited test validation process conducted in our laboratory. In this study, our focus was on establishing a minimum threshold beyond which DNA typing is unnecessary, by defining the correlation of negative quantification results with the absence of genetic profiles resulting from DNA typing. We investigated the results in the range in which the technique is used (50-0.005 ng/μl). In the validation process of the internally accredited method, we used data from the commercial quantification system, based on the average values of the standard curve using a wide range of samples, including artificially degraded samples. This method was extensively used continuously for nine years to quantify the DNA extract coming from a wide range of samples from criminal cases. The validation allowed us to verify the limits of the technique, especially in the use of the minimum quantities necessary to obtain genetic profiles acceptable for sending to the Italian DNA database. This optimization of the protocol for analysing forensic samples allows us to optimise the protocol for analysing forensic samples. However, the technique is used in our laboratory with a completely manual preparative phase, and we have decided to investigate the contribution of human error more accurately. Thus, in our experience, we have found that it is preferable to use quantification ranges rather than exact limits before deciding how to analyse the extracts via PCR. In addition, here we present some preliminary data related to the analysis of certain samples that initially appeared negative during quantification, applying a concentration method for maximum yield from forensic samples of judicial interest. Our aim is to ensure that no source of evidence is lost in the reconstruction of a criminal event.

Preprint ARTICLE | doi:10.20944/preprints202401.2035.v1

Quantification of Circulating Cell-Free DNA in Idiopathic Parkinson’s Disease Patients

Małgorzata Wojtkowska, Natalia Karczewska, Klaudia Pacewicz, Andrzej Pacak, Piotr Kopeć, Jolanta Florczak - Wyspiańska, Karolina Popławska - Domaszewicz, Tomasz Małkiewicz, Bartosz Sokół

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Parkinson`s disease; mitochondria; circulating cell free DNA (ccfDNA); mitochondrial (mtDNA); nuclear (ccfDNA); droplet digital PCR ddPCR

Online: 29 January 2024 (12:45:51 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202302.0359.v1

Uncertainty Quantification in Coastal Aquifers Using the Multilevel Monte Carlo Method

Alexander Litvinenko, Dmitry Logashenko, Raul Tempone, Ekaterina Vasilyeva, Gabriel Wittum

Subject: Environmental And Earth Sciences, Environmental Science Keywords: uncertainty quantification; multigrid; multilevel; density-driven flow; salinization; coastal aquifers; groundwater; salt formations

Online: 21 February 2023 (09:54:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0182.v1

The Patellostabilometer: A New Device for Quantification of Mediolateral Patella Displacement

Krzysztof Lachowski, Florian Hammermeister, Bastian Halenz, Florian Lieckefett, Thomas Götze, Robert Prill, Roland Becker

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: patella mobility; displacement; instability; patella; patellofemoral joint; instrumented measurement; anterior knee pain; knee anatomy; measurement reliability

Online: 9 December 2022 (13:14:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0209.v1

Deep learning with uncertainty quantification for slum mapping using satellite imagery

Thomas Fisher, Harry Gibson, Gholamreza Salimi-Khorshidi, Abdelaali Hassaine, Yutong Cai, Kazem Rahimi, Mohammad Mamouei

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: slums; informal settlements; deep learning; machine learning; uncertainty quantification

Online: 9 August 2021 (20:27:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0404.v1

Circulating Tumor DNA (ctDNA) Methylation Quantification As Diagnostic Biomarker of Pheochromocytomas (PCCs) and Paragangliomas (PGLs)

Fatemeh Khatami, Leonardo Oliveira Reis, Mehdi Ebrahimi, Shirzad Nasiri, Seyed Mohammad Tavangar, Mahin Ahmadi Pishkuhi, Gita Shafiei, Ramin Heshmat, Seyed Mohammad Kazem Aghamir

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ctDNA; liquid biopsy; Methylation; SDHCa; RDBPb; Pheochromocytoma; Paraganglioma

Online: 17 April 2023 (04:54:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0512.v1

Comparison of Identification and Quantification of Polyphe-Nolic Compounds in Skins and Seeds of Four Grape Varieties

Zlatina Chengolova, Yavor Ivanov, Tzonka Godjevargova

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: grape skins; seeds; polyphenolic composition; antioxidant potential; RT-HPLC

Online: 18 April 2023 (10:22:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0511.v1

Mid-infrared Laser Spectroscopy Detection and Quantification of Explosives in Soils Using Multivariate Analysis and Artificial Intelligence

Leonardo C. Pacheco-Londoño, Eric Warren, Nataly J. Galan-Freyle, Reynaldo Villarreal-Gonzalez, Joaquin A. Aparicio-Bolaño, Maria L. Ospina-Castro, Wei-Chuan Shih, Samuel P. Hernandez-Rivera

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: quantum cascade laser; remote detection; partial least squares; high explosives; artificial intelligence; machine learning

Online: 31 May 2020 (20:57:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0482.v1

Shear Stress Quantification in Tissue Engineering Bioreactor Heart Valves: A Computational Approach

Raj Dave, Giulia Luraghi, Leslie Sierad, Francesco Migliavacca, Ethan Kung

Subject: Engineering, Bioengineering Keywords: wall shear stress quantification; TEHV; FSI; CFD; Computational Model

Online: 5 January 2024 (12:13:56 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202303.0143.v1

Optimized Protocol for Preservation of Human Platelet Samples for Fluorometric Polyphosphate Quantification

Tomoyuki Kawase, Katsuya Suzuki, Masami Kamimura, Tomoharu Mochizuki, Takashi Ushiki

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: platelets; polyphosphate; preservation

Online: 8 March 2023 (03:04:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0652.v3

Self-Quantification Systems to Support Physical Activity: From Theory to Implementation Principles

Paul Dulaud, Ines Di Loreto, Denis Mottet

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: quantified self; health; physical activity; behavior change; model; support system; persuasive design; user centered design

Online: 7 December 2020 (10:53:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0047.v1

Direct Quantification by Infrared Spectroscopy of Drug Loading Content in Polymeric Nanoparticles

Guzmán Carissimi, Mercedes G. Montalbán, Gloria Víllora, Andreas Barth

Subject: Medicine And Pharmacology, Pharmacy Keywords: silk fibroin; nanoparticles; drug loading content; quantification; infrared spectroscopy; FTIR spectroscopy.; nanotechnology; nanomedicine; drug delivery; controlled release

Online: 3 September 2020 (03:56:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1052.v4

Innovative Cloud Quantification: Deep Learning Classification and Finite Sector Clustering for Ground-Based All Sky Imaging

Jingxuan Luo, Yubing Pan, Debin Su, Jinhua Zhong, Lingxiao Wu, Wei Zhao, Xiaoru Hu, Zhengchao Qi, Daren Lu, Yinan Wang

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: cloud quantification; deep neural networks; adaptive segmentation; finite element clustering; whole sky image

Online: 16 April 2024 (02:39:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0067.v1

Rapid In-Field Volatile Sampling for Detection and Quantification of Botrytis cinerea Infection in Wine Grapes

Liang Jiang, Morphy C. Dumlao, William A. Donald, Christopher C. Steel, Leigh Mervyn Schmidtke

Subject: Biology And Life Sciences, Horticulture Keywords: quality assessment; plant disease; rapid sampling; analysis; metal-organic frameworks; thermal desorption; GC-MS; VOCs

Online: 1 June 2023 (08:38:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0249.v1

Quantification of Lithium Plating in Lithium-Ion Batteries Based on Impedance Spectrum and Artificial Neural Network

Miao Bai, Chao Lyu, Dazhi Yang, Gareth Hinds

Subject: Engineering, Electrical And Electronic Engineering Keywords: Artificial neural network; Lithium plating quantification; Equivalent circuit model; Parameter identification; Feature parameters extraction

Online: 4 May 2023 (09:59:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0034.v3

Abnormality Detection and Failure Prediction Using Explainable Bayesian Deep Learning: Methodology and Case Study of Real-World Gas Turbine Anomalies

Ahmad Kamal Mohd Nor, Srinivasa Rao Pedapati, Masdi Muhammad, Víctor Leiva

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Artificial intelligence; CMAPSS; consistency and local accuracy; CUSUM chart; deep learning; prognostic and health management; RMSE; sensing and data extraction; SHAP; Uncertainty; XAI

Online: 12 January 2022 (10:22:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202308.0284.v1

Designing and Validation of a Droplet Digital PCR Procedure for Diagnosis and Accurate Quantification of Nervous Necrosis Virus

Sandra Souto, José G. Olveira, Carmen López-Vázquez, Isabel Bandín, Carlos P. Dopazo

Subject: Biology And Life Sciences, Virology Keywords: VNNV; Diagnosis; Validation; dPCR; droplet digital PCR.

Online: 3 August 2023 (10:44:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0279.v1

Quantification of DNA of Fusarium culmorum and Trichothecene Genotypes 3ADON and NIV in the Grain of Winter Wheat

Tomasz Góral, Jarosław Przetakiewicz, Piotr Ochodzki, Barbara Wiewióra, Halina Wiśniewska

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chemotype; 3ADON; DNA; Fusarium; Fusarium head blight; NIV; real-time PCR; wheat

Online: 15 November 2022 (07:09:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0302.v1

Quantification of Error Sources in Wave Runup Estimates on Two Mediterranean Sandy Beaches

Miguel Agulles, Gabriel Jordà

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: wave runup; uncertainty; numerical modeling; empirical equation; sandy beaches

Online: 16 March 2023 (09:44:51 CET)

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Projected future sea level rise and marine storminess is a serious threat for beaches as they induce beach flooding and erosion. Among other factors, wave runup play an important role in beach evolution and must be robustly assessed. However, little attention has been paid to the uncertainties associated to its characterization and how do they compare to other sources of uncertainty. As a first step towards this goal, we have quantified the impact of several sources of error in the estimation of wave runup on sandy beaches. Understanding what factors are more influential in the quality of the results will help to determine the main sources of uncertainty in beach flooding projections. To reach that goal, a calibrated state-of-the-art numerical modelling system has been setup for two beaches in the Mallorca islands (NW Mediterranean). The system has been forced with the best available information of nearshore incoming waves and has been validated against observations to define the benchmark quality. To determine the key factors affecting the quality of the system’s results, different systems configurations have been tested with different degrees of complexity.Our results show that using the most sophisticated modelling system with the best information on boundary conditions, bottom bathymetry, and submerged vegetation leads to a swash RMSE comparable to the standard deviation of the observed swash. We have also found that the choice of lateral boundary conditions (i.e., source of information for the incoming waves) can double the RMSE and induce large biases. Our results also show that using a simple empirical approach usually underestimates the wave runup. However, in locations with vegetated seabed there is a compensation error, and the empirical approach can lead to acceptable results if forced by nearshore waves. In addition, we have compared the error estimates obtained with uncertainties associated to projected sea level rise. Our findings suggest that the uncertainty associated with wave runup modelling should be considered in the assessment of the total uncertainty of future beach flooding, since the analysis performed indicates that this uncertainty can account for between 16% to 60% of the uncertainties linked to mean sea level projections.

Preprint ARTICLE | doi:10.20944/preprints202211.0569.v1

Quantitative ¹H Nuclear Magnetic Resonance (qNMR) of Aromatic Amino Acids for Protein Quantification

Teodor Tchipilov, Klas Meyer, Michael G. Weller

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: amino acid analysis; AAA; protein hydrolysis; metrology; traceability; reference materials; internal standards; calibration

Online: 30 November 2022 (09:17:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0695.v1

ZFTool: A Software for Automatic Quantification of Cancer Cell Mass Evolution in Zebrafish

María J. Carreira, Nicolás Vila-Blanco, Pablo Cabezas-Sainz, Laura Sanchez

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: xenotransplant; cancer cells; zebrafish image analysis; in vivo assay

Online: 30 July 2021 (10:39:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0508.v1

Quantification of the Direct Solar Impact on Some Components of the Hydroclimatic System

Mares Constantin, Mares Ileana, Dobrica Venera, Demetrescu Crisan

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: time series; causality; entropy transfer; wavelet analysis; neural networks; climate response; solar impact

Online: 19 April 2021 (16:33:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0289.v1

Sphingolipidome Quantification by Liquid Chromatography- High Resolution Mass Spectrometry: Whole Blood vs. Plasma

Dezhen Wang, Peining Xu, Clementina Mesaros

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: sphingolipidome; ceramides; high resolution mass spectrometry; whole blood; plasma

Online: 10 March 2021 (16:06:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1107.v1

Time Evolution of the Symmetry of Alphabet Symbols and Its Quantification: Study in the Archeology of Symmetry

Artem Gilevich, Mark Frenkel, Shraga Shoval, Edward Bormashenko

Subject: Arts And Humanities, Archaeology Keywords: Phoenician alphabet; symmetry; symmetry group; grapheme; time evolution; Shannon measure of symmetry; Shannon diversity index

Online: 14 December 2023 (13:58:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1463.v1

Quantification of hs-Troponin Level and Global Longitudinal Strain among Critical COVID-19 Patients with Myocardial Involvement

Mochamad Yusuf Alsagaff, Louisa Fadjri Kusuma Wardhani, Ricardo Adrian Nugraha, Tony Santoso Putra, Bagus Putra Dharma Khrisna, Makhyan Jibril Al-Farabi, Ruth Irena Gunadi, Yusuf Azmi, Christian Pramudita Budianto, Rosi Amrilla Fagi, Nadya Luthfah, Agus Subagjo, Yudi Her Oktaviono, Achmad Lefi, Budi Baktijasa Dharmadjati, Budi Susetyo Pikir, Firas Farisi Alkaff

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: COVID-19; hs-Troponin; global longitudinal strain; intubation; myocarditis

Online: 24 October 2023 (07:51:05 CEST)

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Myocardial involvement among critical patients with coronavirus disease 2019 (COVID-19) has a worse outcome. The occurrence of an imbalance in oxygen supply results in the release of pro-inflammatory cytokines which leads to increased ventilation support requirement and increase risk of mortality. Our aim was to evaluate the association between hs-Troponin I level and global longitudinal strain as evidence of myocardial involvement among critical COVID-19 patients. Methods. We performed prospective cohort study from February 1st – July 31st, 2021 at Dr. Soetomo General Hospital, Surabaya as referral center for COVID-19 care. Of the 65 critical COVID-19 included, 41 (63.1%) were men, with a median (interquartile range) age of 51.0 years (20.0-75.0).Subjects were recruited according to WHO criteria for severe COVID-19 and CDC criteria for myocarditis. All subjects recruited were examined using echocardiography to measure global longitudinal strain (GLS) and blood samples were taken to measure hs-Troponin. Subjects were then followed to assess their needs for mechanical ventilation and in-hospital mortality. Severe COVID-19 subjects with cardiac injury were associated with an increased need for intubation (78.5%) and an increased incidence of myocarditis (50.8%). There was an association between the use of intubation and the risk of mortality in patients (66.7% vs. 33.3%, p-value <0.001). Both reduced GLS and increased hs-troponin are associated with increased myocarditis (p-value <0.001 and 0.004 respectively). Reduced GLS is associated with higher mechanical ventilation needs (12.17 + 4.79 vs.15.65 + 4.90, p-value 0.02) and a higher mortality rate (11.36 + 4.64 vs. 14.74 + 4.82; p-value 0.005). Increased hs-troponin is associated with higher mechanical ventilation needs (25.33% vs. 3.56%, p-value 0.002) and a higher mortality rate (34.57% vs. 5.76%, p-value 0.002). Compared with contemporary controls, critical COVID-19 patients with myocardial involvement and elevated cardiac troponin level are associated with higher mechanical ventilation needs and a higher mortality rate.

Preprint ARTICLE | doi:10.20944/preprints201809.0359.v1

In-Situ Coherent X-Ray Diffraction during Three-Point Bending of a Au Nanowire: Visualization and Quantification

Anton Davydok, Thomas W. Cornelius, Zhe Ren, Cedric Leclere, Gilbert Chahine, Tobias Schülli, Florian Lauraux, Gunter Richter, Olivier Thomas

Subject: Chemistry And Materials Science, Nanotechnology Keywords: synchrotron X-ray diffraction; nano-structures; nano mechanics

Online: 18 September 2018 (16:50:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0557.v1

Reproducible Quantification of the Microstructure of Complex Quenched and Quenched and Tempered Steels using Modern Methods of Machine Learning

Björn-Ivo Bachmann, Martin Müller, Dominik Britz, Thorsten Staudt, Frank Mücklich

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: microstructure classification; microstructure segmentation; machine learning; quenched steel; martensite; bainite

Online: 10 July 2023 (09:00:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1876.v1

Quantification of Analgesic and Anti-inflammatory Lipid Mediators in Long-Term Cryopreserved and Freeze-Dried Preserved Human Amniotic Membrane

Vladimír Vrkoslav, Ingrida Smeringaiova, Natalia Smorodinova, Alzbeta Svobodova, Stepan Strnad, Catherine Joan Jackson, Jan Burkert, Katerina Jirsova

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: amniotic membrane allografts; cryopreserved amniotic membrane; lyophilization; freeze-dried amniotic membrane; N-acylethanolamines; palmitoylethanolamide; tissue banking; mass spec-trometry

Online: 26 May 2023 (07:29:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0286.v1

Quantification of the Post-Fire Strength Retention Factors for Selected Standard Duplex and Lean Duplex Stainless Steel Grades

Mariusz Maslak, Krzysztof Pancikiewicz, Michal Pazdanowski, Marek Stankiewicz, Piotr Wozniczka, Paulina Zajdel

Subject: Engineering, Civil Engineering Keywords: stainless steel; standard duplex steel; lean duplex steel; post-fire strength; post-fire ductility; retention factors; recovery factors

Online: 5 December 2023 (17:03:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0259.v1

In Vivo Renal Lipid Quantification by Accelerated Magnetic Resonance Spectroscopic Imaging at 3 T: Feasibility and Reliability Study

Ahmad A. Alhulail, Mahsa Servati, Nathan Ooms, Oguz Akin, Alp Dincer, M. Albert Thomas, Ulrike Dydak, Uzay E. Emir

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: kidney; renal; lipid; fast MRSI

Online: 18 March 2022 (02:59:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0543.v1

Apoptosis Quantification in Tissue: Development of a Semi- automatic Protocol and Assessment of Critical Steps of Image Processing

Juliette de Noiron, Marion Hoareau, Jessie Colin, Isabelle Guénal

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Apoptosis; TUNEL; Caspase; image processing; thresholding; signal quantification; Drosophila

Online: 23 July 2021 (11:55:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0264.v1

Rapid Quantification and Neutralization Assays for Novel Coronavirus SARS-CoV-2 Using Avicel RC-591 Semi-Solid Overlay

Anna N. Honko, Nadia Storm, David J. Bean, Jhonatan Henao Vasquez, Sierra N. Downs, Anthony Griffiths

Subject: Biology And Life Sciences, Virology Keywords: plaque assay; neutralization; SARS; SARS-CoV-2; coronavirus; Avicel; methylcellulose; COVID

Online: 16 May 2020 (15:51:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0911.v1

Improved detection of 2,3-diaminophenazine for horseradish peroxidase quantification using surface-enhanced Raman spectroscopy

Evgeniy G. Evtushenko, Elizaveta S. Gavrilina, Alexandra D. Vasilyeva, Lyubov V. Yurina, Ilya N. Kurochkin

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Surface-enhanced Raman spectroscopy; SERS; horseradish peroxidase; HRP; ELISA; 2,3-diaminophenazine; DAP; o-phenylenediamine; 1,2-diaminobenzene; oPD

Online: 12 December 2023 (21:10:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1452.v1

Fast Bimetallic Nanoalloy Quantification Method Using X-ray Fluorescence Spectroscopy for High-Throughput Experiments

Le Nguyen-Vu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: quantitative analysis; X-ray fluorescence spectroscopy; bimetallic nanoparticle; nanoparticle concentration

Online: 23 November 2023 (03:37:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1028.v1

Uncertainty Quantification of GEDI Clear-Sky Terrain Height Retrievals Using a Mixture Density Network

Jonathan Sipps, Lori A. Magruder

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: GEDI; laser altimetry, lidar, uncertainty quantification; mixture density network; terrain elevation

Online: 17 October 2023 (12:00:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2136.v1

Enhancing the Yield of Lab-on-a-Disk Based Single Image Parasite Quantification Device

Vyacheslav R Misko, Ramadhani Juma Makasali, Matthieu Briet, Filip Legein, Bruno Levecke, Wim De Malsche

Subject: Biology And Life Sciences, Parasitology Keywords: particle separation; parasite egg identification and quantification; diagnostic microfluidic device; extreme point-of-care

Online: 30 September 2023 (07:18:51 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202211.0165.v1

Data-Independent Acquisition (DIA) is Superior for High Precisely Phospho-Peptide Quantification in Fungi

Katharina Bersching, Thomas Michna, Stefan Tenzer, Stefan Jacob

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Proteomics; LC-MS/MS; phosphopeptide enrichment; bioinformatics; cellular signaling; Mag-naporthe oryzae; phosphorylation; DDA; DIA; phospho-peptidomics

Online: 9 November 2022 (02:09:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0212.v1

Comparison of Different Label-free Techniques for the Semi-absolute Quantification of Protein Abundance

Aarón Millán-Oropeza, Mélisande Blein-Nicolas, Véronique Monnet, Michel Zivy, Céline Henry

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: label free; metabolic models; Saccharomyces; semi-absolute quantification; quantitative proteomics; TPA; UPS2.

Online: 13 December 2021 (16:04:34 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202109.0183.v1

CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin

Annelien Morlion, Eva Hulstaert, Jasper Anckaert, Celine Everaert, Jo Vandesompele, Pieter Mestdagh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: bioinformatics; circRNA

Online: 10 September 2021 (11:17:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0472.v1

Quantification of Doughnut Economy with the Sustainability Window method: Analysis of Development in Thailand.

Jyrki Luukkanen, Jarmo Vehmas, Jari Kaivo-oja

Subject: Business, Economics And Management, Accounting And Taxation Keywords: sustainability; advanced sustainability analysis (ASA); sustainable development goals (SDGs); indicators; demonstration study; Doughnut economy; Sustainability Window; Thailand

Online: 18 December 2020 (14:51:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0228.v1

Quantification of the Impact of Photon Distinguishability on Measurement-Device- Independent Quantum Key Distribution

Garrett Simon, Blake Huff, William Meier, Lee Harrell

Subject: Physical Sciences, Quantum Science And Technology Keywords: Measurement-Device-Independent Quantum Key Distribution; Quantum Optics; Two-Photon Interference

Online: 27 March 2018 (15:24:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0573.v1

Determination and Quantification of Acetaldehyde, Acetone and Methanol in Hand Sanitizes Using Headspace GC-MS: Effect of Storage Time and Temperature

Jacob Abraham Theruvathu, Chessa To

Subject: Chemistry And Materials Science, Other Keywords: Hand sanitizer; alcohol; acetaldehyde; acetone; GC/MS; isotope; storage time; temperature

Online: 9 November 2023 (07:25:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0596.v1

Quantification and Influence by IL-1β of the Pain and Inflammatory Response after Placement of a Cement-Screw-Retained Restoration

Serafín Maza-Solano, María Baus-Domínguez, Raquel Gómez-Díaz, Gonzalo Ruiz-de-Leon-Pacheco, Daniel Torres-Lagares, María-Angeles Serrera-Figallo

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Screw-cemented retained implant prothesis; customised CAD-CAM abutments; peri-implant crevicular fluid; healing abutments; dental implants.

Online: 9 February 2024 (13:54:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0010.v1

Using Remote Sensing Multispectral Imagery for Invasive Species Quantification: The Effect of Image Resolution on Area and Biomass Estimation

Manuel de Figueiredo Meyer, José Alberto Gonçalves, Ana Maria Ferreira Bio

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Carpobrotus edulis; Unoccupied Aerial Vehicle; Above-ground Biomass; GIS; QGIS; Landcover Classification

Online: 3 January 2024 (02:10:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0215.v1

Protein and mRNA Quantification in Small Samples of Human Induced Pluripotent Stem-cell-derived Cardiomyocytes in 96-well Microplates

Weizhen Li, Julie Han, Emilia Entcheva

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: high-throughput; hiPSC-CMs; Wes ProteinSimple; Cells-to-CT; Cx43; ChR2; optogenetic

Online: 13 December 2021 (16:13:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201903.0036.v1

Aligning the Aligners: Comparison of RNA Sequencing Data Alignment and Gene Expression Quantification Tools for Clinical Breast Cancer Research

Isaac Raplee, Alexei Evsikov, Caralina Marín de Evsikova

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast neoplasms, ductal carcinoma in situ (DCIS), gene expression profiling, high-throughput nucleotide sequencing, infiltrating ductal carcinoma (IDC), paraffin embedding, sequence alignment, transcriptome

Online: 4 March 2019 (10:23:25 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201806.0441.v2

A Simple Unified Equation for Accurate and Rapid Quantification of Fe³⁺/∑FeObtained from Room Temperature Mössbauer Spectroscopic Measurements

Jacob Adetunji

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Mössbauer spectroscopy; recoilless fractions; corrected Fe3+/∑Fe ratios; room temperature measurements

Online: 11 July 2018 (12:17:20 CEST)

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The accurate quantification of

\frac{F e^{3 +}}{Σ F e}

ratios for Mössbauer spectroscopic room temperature measurements involves many steps and, when shown in a composite Mössbaur data table, does not allow enough space for more Mössbauer parameters to be presented in the composite table. So a simple formula is derived, (presented as a short communication) which users will find helpful when they have to determine corrected

\frac{F e^{3 +}}{Σ F e}

ratios in their room temperature Mössbauer experiments.

Preprint ARTICLE | doi:10.20944/preprints202311.1638.v1

Using the ISO 9705 Room Corner Test for Smoke Toxicity Quantification of Oriented Strand Board

Gabrielle Peck

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: Smoke Toxicity; Large-Scale; Oriented Strand Board; ISO 9705; Flammability

Online: 28 November 2023 (01:40:57 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202309.1527.v1

Quantification of the Number of Nuclear Gems as a Potential Biomarker for Spinal Muscular Atrophy

Haya Al-Hilal, Marianna Maretina, Anna Egorova, Andrey Glotov, Anton Kiselev

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: spinal muscular atrophy; SMN1 gene; SMN2 gene; nuclear gems; antisense oligonucleotides; splicing correction.

Online: 22 September 2023 (09:19:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0278.v1

Developing of a New Analytical Tool for Quantification of Fibroblast Growth Factor-23 – SPRi Biosensor.

Anna Tokarzewicz, Lukasz Oldak, Grzegorz Młynarczyk, Urszula Klekotka, Ewa Gorodkiewicz

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: FGF-23; Fibroblast growth factor; Surface Plasmon Resonance Imaging; biosensors

Online: 5 July 2023 (11:22:42 CEST)

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Working Paper ARTICLE

Fold-change-Specific Enrichment Analysis (FSEA): Quantification of Transcriptional Response Magnitude for Functional Gene Groups

Daniil S. Wiebe, Nadezhda A. Omelyanchuk, Aleksei M. Mukhin, Ivo Grosse, Sergey A. Lashin, Elena V. Zemlyanskaya, Victoria V. Mironova

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gene expression; Gene Ontology; Enrichment analysis; Transcriptomics

Online: 2 April 2020 (11:51:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0025.v1

Quantification of the Energy Storage Contribution to Security of Supply through the F-Factor methodology

Spyros Giannelos, Predrag Djapic, Danny Pudjianto, Goran Strbac

Subject: Engineering, Electrical And Electronic Engineering Keywords: f-factors; energy storage; investments in electricity systems; mathematical optimization; security of supply

Online: 3 December 2019 (11:52:19 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0327.v1

A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs

Andrea LA Wong, Xiaoqiang Xiang, Pei Shi Ong, Qin Ying Mitchell Ee, Nicholas Syn, Wee Ian, Alan Prem Kumar, Wei Peng Yong, Gautam Sethi, Boon Cher Goh, Paul Chi-Lui Ho, Lingzhi Wang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: LC-MS/MS, Rapid, Quantification, Oncology Drugs

Online: 15 October 2018 (16:57:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0527.v1

Transcriptome-wide Identification and Quantification of Caffeoylquinic Acid Biosynthesis Pathway and Prediction of their Putative BAHDs Gene Complex in A. spathulifolius

SeonJoo Park, Jean Claude Sivagami, Sunmi Park

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Phenylpropanoid pathway; Caffeoylquinic acid; BAHDs; hydroxycinnamoyl-coenzyme A: quinate hydroxycinnamoyl transferase; hydroxycinnamoyl-coenzyme A: shikimate/quinate hy droxycinnamoyl transferase;

Online: 21 May 2021 (15:13:15 CEST)

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