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Preprint ARTICLE | doi:10.20944/preprints202404.1629.v1

Burr Hole Craniostomy Versus Craniotomy for Chronic Subdural Hematoma – A Multicenter Study

Nenad Koruga, Djula Djilvesi, Anamarija Soldo Koruga, Vjekoslav Kopačin, Tatjana Rotim, Tajana Turk, Slavko Čičak, Josip Kocur, Marija Perić, Tomislav Ištvanić, Vedran Farkaš, Sonja Škiljić, Alen Rončević

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Burr hole craniostomy; Craniotomy; Chronic subdural Hematoma; Multicenter study

Online: 25 April 2024 (08:38:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0912.v2

Comparative Analysis of Rapid and Less Invasive Methods for A2A2 Dairy Cattle Genotyping and A2 Milk Purity Detection

Leandra Oliveira Xavier Albiero, Rafaela Ansiliero, Aniela Pinto Kempka

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: A2A2 dairy cows; Genotyping; ELISA; LFIA; Comparison of methods; Facilitated analysis

Online: 14 August 2024 (11:56:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0707.v1

Associations among Beliefs Supporting Patriarchal Principles, Conflict Avoidance, and Economic Violence in Intimate Partner Relationships of Ultraorthodox Jews

Ruth Berkowitz, David Mehlhausen-Hassoen, Zeev Winstok

Subject: Social Sciences, Behavior Sciences Keywords: patriarchal principles; conflict avoidance; economic violence; intimate partner violence

Online: 10 September 2024 (08:00:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0692.v1

Pancreatic Neuroendocrine Tumors: What Is the Best Surgical Option?

Renato Patrone, Federico Maria Mongardini, Alessandra Conzo, Chiara Cacciatore, Giovanni Cozzolino, Antonio Catauro, Eduardo Lanza, Francesco Izzo, Andrea Belli, Raffaele Palaia, Luigi Flagiello, Ferdinando De Vita, Ludovico Docimo, Giovanni Conzo

Subject: Medicine And Pharmacology, Surgery Keywords: pNET; Neuroendocrine tumors; Pancreas tumor; pancreatic cancer; enucleation; Pancreatectomy

Online: 10 April 2024 (13:05:26 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202406.0779.v1

IC Regimen: Delaying Resistance to Lorlatinib in ALK Driven Cancers Using Repurposed Itraconazole and Cilostazol

RICHARD E. KAST

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ALK kinase; cilostazol; Hedgehog; itraconazole; large cell neuroendocrine cancer; non-small cell lung cancer; platelets

Online: 12 June 2024 (11:58:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1072.v1

Bridging the Connection Between Fluency in Reading and Arithmetic

Reut Balhinez, Shelley Shaul

Subject: Social Sciences, Education Keywords: Reading Fluency; Arithmetic Fluency; Executive Functions

Online: 17 June 2024 (08:34:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0061.v1

Past and Future Impacts of the Relative Sea Level Rise on the Seafront of Ancient Delos (Cyclades, Greece) and Flooding Scenarios by 2150

Nikos Mourtzas, Eleni Kolaiti

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: ancient Delos; Cyclades; Aegean; Greece; past sea level changes; ancient sea defences; sea level projections; vertical land motion; flooding scenarios up to 2150; mitigation and adaptation measures

Online: 1 May 2024 (07:53:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0415.v1

Multicenter Retro-Prospective Observational Study on Chronic Hypoparathyroidism and rhPTH (1-84) Treatment

Gemma Marcucci, Guglielmo Beccuti, Giulia Carosi, Filomena Cetani, Luisella Cianferotti, Anna Maria Colao, Carolina Di Somma, Mirko Duradoni, Antonia Elefante, Lucia Ghizzoni, Massimo Giusti, Andrea Gerardo Lania, Elisabetta Lavezzi, Bruno Madeo, Giovanna Mantovani, Claudio Marcocci, Laura Masi, Simone Parri, Francesca Pigliaru, Assunta Santonati, Antonio Spada, Lara Vera, Maria Luisa Brandi

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Chronic Hypoparathyroidism; rhPTH (1-84); Natpar®; Treatment

Online: 24 December 2021 (23:55:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0391.v1

Biopsychosocial impediments in MS: Gender Differences and Impact of Quality of Life on Neuropsychological Function: Multicenter study

Maisaa Ghanim Al Dhahri, Mai Helmy, Neeraja Rajeev, Aseel Al Toubi, Hiba Al-Abdali, Abdullah Al-Asmi, Iman Redha Al-Lawati, Issa Al-Adawi, Lakshmanan Jeyaseelan, Samir Al-Adawi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Multiple sclerosis, neuropsychological performance, gender differences, quality of life, and cognitive functioning

Online: 5 September 2024 (09:28:07 CEST)

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Background/Objectives: Multiple sclerosis (MS) is a chronic neurological disorder characterized by various clinical presentations and manifestations that include biopsychosocial impediments. This study has three interrelated goals relevant to biopsychosocial functioning. The first is to compare cognitive, neuropsychological, and affective functioning and quality of life between patients with MS (PwMS) and a control group. The second is to examine whether cognitive and neuropsychological performance is affected by gender, and the third is to examine whether variation in QoL hinges on cognitive neuropsychological performance. Methods: This multicenter study was carried out among clinically stable PwMS under follow-up in two tertiary care units in urban Oman. Healthy controls, matched for age and sex, were also recruited as a comparison group. Data were collected using cognitive batteries sensitive to current reasoning ability and conventional neuropsychological batteries designed to measure verbal learning, visual-spatial ability, and processing speed. The affective range (anxiety and depressive symptoms) and quality of life (QoL) were also assessed. Results: The PwMS group scored lower on current reasoning ability, verbal learning, visual-spatial ability, and processing speed compared with the control group. The incidence of anxiety was higher in the PwMS group but there was no statistically significant difference in depressive symptoms. No significant differences were found in cognitive variables between the two sexes, except in visual-spatial ability, where women outperformed men. PwMS with low QoL scored lower on the attention and concentration indices than those with adequate QoL. According to QoL, no significant differences were observed in reasoning, verbal learning, and visual-spatial ability. Conclusions: The present sentinel study suggests that the Omani cohort with MS tends to have lower indices of current reasoning ability, visual and spatial memory and cognitive speed compared to control subjects. Gender differences are minimal, except for visual-spatial abilities where women outperform men. Quality of life significantly affects cognitive functioning. In general, the biopsychosocial impediment appears to be significant, indicating the need for comprehensive evaluation and care in the management of MS.

Preprint BRIEF REPORT | doi:10.20944/preprints202402.1536.v1

User Manual for Coping Strategies Inventory Short Form (CSI-SF) -The Jackson Heart Study

Clifton Addison, Brenda Jenkins, Monique White

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Jackson Heart Study; Coping; Validity; Reliability; CSI-SF Manual; African Americans

Online: 27 February 2024 (12:37:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1130.v1

Mechanism for Enhancing the Sustainability of Regional Export Flows in Global Systems: A Case Study of Russian Cereal Exports

Galina Anatolievna Khmeleva, Marina Viktorovna Kurnikova, Elena Alexandrovna Kandrashina, Maria Sergeevna Guseva

Subject: Social Sciences, Transportation Keywords: grain trade; export sustainability; gravity model; trade flows; Russian regions; sustainable development

Online: 15 August 2024 (22:49:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0747.v1

Surgical Strategy for Repair of Acute Type A Aortic Dissection: A Multicenter Study

Francesco Nappi, Sanjeet Singh Avtaar Singh, Ivancarmine Gambardella, Alzamil Almothana, Antonio Salsano, Francesco Santini, Fausto Biancari, Thibaut Schoell, Nicolas Bonnet, Thierry Folliguet, Antonio Fiore

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Type A Acute Aortic dissection; ascending aorta replacement; aortic arch repair; total arch replacement procedure; cerebrovascular perfusion

Online: 23 April 2023 (03:37:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0091.v1

Enhancing Medical Tourism In Bali: A Readiness Analysis of Siloam Hospital Through Actor-Network Theory (ANT)

Ni Gusti Ayu Putri Mayuni, Ida Ayu Oka Martini

Subject: Public Health And Healthcare, Other Keywords: medical tourism; private hospitals; bali; actor-network theory; readiness; siloam hospital bali

Online: 3 September 2024 (03:33:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1315.v1

Nusinersen Treatment for Spinal Muscular Atrophy: Retrospective Multicenter Study of Pediatric and Adult Patients in Kuwait

Asma Tawari, Mohammad Zakaria, Walaa Kamel, Laila Bastaki, Gamal Ahmed Ismail Elghazawi, Mohamed Esmat Anwar Ali, Dalia Salota, Amer Attia, Ehab Elsayed Ali Elanay, Osama Shalaby, Fatema Alqallaf, Vesna Mitic, Nayera Shaalan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: spinal muscular atrophy; neuromuscular disease; nusinersen; antisense oligonucleotide; pediatrics

Online: 19 April 2024 (08:05:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0064.v1

Chemotherapy-Induced Nausea and Vomiting Breast Cancer Patients from a Chinese Multicenter Prospective Longitudinal Observational Study

Xin-Juan Huang, Xu-Ying Li, Lu Luo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: CINV; breast cancer; antiemetic guidelines; risk factors

Online: 2 June 2021 (10:06:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0142.v1

Non-Union Treatment in the Foot, Ankle, and Lower Leg: A Multicenter Retrospective Study Comparing Conventional Treatment with the Human Allogeneic Cortical Bone Screw (Shark Screw®)

Viktor Labmayr, Elisabeth Huber, Florian Wenzel-Schwarz, Patrick Holweg, Martin Ornig, Gerd Jakob, Wolfgang Palle, Gudrun H. Borchert, Klaus Pastl

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: bone healing; non-union; human allogeneic cortical bone screw; Shark Screw®; ; allograft; pseudarthrosis; foot and ankle; time to union; delayed union; return to work; hardware removal; health care costs

Online: 4 March 2024 (14:04:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0093.v1

Identification of Research Priorities in Infertility and Assisted Reproduction: An International, Multicenter Study in Partnership with Patients

D García, F Lindenberg, E Toft, A La Marca, R Borrás, AR Lorenzon, MB Chehin, L Silva, ELA Motta, M Ripero, j Madero, RM Marinho, CA Oliveira, JPJ Caetano, A Bolívar, S Brazal, A Rodríguez, R Vassena

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Patients involvement; research interests; ART treatments; treatment personalization; psychological effects; healthy habits; fertility protection; infertility prevention; lifestyle; diet

Online: 8 April 2019 (12:46:17 CEST)

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STUDY QUESTION: Which are the main research interests among patients of assisted reproductive technologies (ART)? SUMMARY ANSWER: Patients identified as research priorities that deserve further investigation: success rates and risks of ART, side-effects of treatments, resources to cope with infertility, effectiveness of alternative therapies, lifestyle habits to protect fertility, oocyte quality and ovarian reserve, and causes of genetic or hereditary infertility. WHAT IS KNOWN ALREADY: The involvement of patients and caregivers in setting research agendas in medicine has gathered significant momentum in the last decade. Patients’ involvement in setting research priorities offers several benefits: improved patient knowledge and awareness of their condition; greater understanding of the medical professionals of the impact of the condition on patients’ quality of life; reduced costs associated with redundant research activities. This is may be also applicable to research in infertility and ART, where patients’ interests have never been explored before. STUDY DESIGN, SIZE, DURATION: This is a cross-sectional study that consists of an anonymous online survey, which was sent up to three times to 2112 patients from 11 fertility centers in 5 countries between January-December 2018. The study design was based on the James Lind Alliance priority setting partnership model, which comprises the identification of patients groups, the exploration of the research agenda, the analysis of collected data and identification of priorities. PARTICIPANTS/MATERIALS, SETTING, METHODS: Overall, 2112 patients were contacted, and 945 surveys were answered (RR: 44.7%). Patients were asked to identify research questions relevant to them in the areas of infertility causes and prevention, fertility treatments (medication and ART), and the emotional aspects of infertility. Answers were categorized in topics and ranked by frequency. A long list of the top-30 research topics was extracted from the aggregate results, from which, a short list of the top-10 research topics was created. At the end, 10 research questions related to each of the 10 research topics were constructed, based on the answers given by patients. MAIN RESULTS AND THE ROLE OF CHANCE: Female (845, 89.4%) and male (100, 10.6%) patients were included. The mean age of patients was 37.8 (SD 1.74). Most of the patients did not have children at the time of the survey (523, 59%), while 51 (5.7%) were pregnant. Sixty (6.3%) patients did not start treatment, 579 (61.3%) were performing a treatment with their own gametes and 304 (32.2%) were treated through gamete donation. Patients were mainly interested in the effectiveness of ART -especially per clinical profile-, side effects of drugs, protection of fertility and prevention of infertility –especially through diet and exercise-, and psychological aspects of the infertility journey. The top-10 research questions (and weight) obtained were: 1) What are the side-effects of ART treatments? (41.6%); 2) What are the most effective methods to cope with infertility from the psychological point of view? (37.2%); 3) What effects could diet have on fertility? (25.9%); 4) What are ART success rates per clinical profile? (25.9%); 5) Are there habits and lifestyle factors that could prevent infertility? (20.0%); 6) What are the long-term risks associated to ART? (18.5%); 7) Are alternative therapies such as acupuncture, yoga, and meditation effective to treat/prevent infertility? (18.5%); 8) What is the impact of exercise on fertility? (15.4%); 9) How does oocytes quantity and quality affect fertility? (9.5%); 10) What are the genetic patterns or hereditary conditions causing/related to infertility? (9.5%). LIMITATIONS, REASONS FOR CAUTION: Although all respondents had attended a fertility center, not all of them were diagnosed as infertile (i.e. single women) and had started treatment at the time of response, while a few were pregnant; their priorities for research might have been influenced by their infertility journey. Also, all participants attended private fertility centers: areas of interest may be different in public settings. WIDER IMPLICATIONS FOR THE FINDINGS: Researchers and clinicians should keep in mind that, in addition to improvement of treatments’ success rates and side-effects, patients greatly value research on causes, prevention and emotional aspects of infertility. As their views might differ from those of medical professionals, patients’ voices should be incorporated in setting infertility research priorities.

Preprint ARTICLE | doi:10.20944/preprints202408.1246.v1

Multicenter Perioperative Results with a New Endoscopic Powered Stapler in Bariatric Surgery: A Retrospective Study

Athar Khan, Laurent Layani, Nalini Kiran, Basel Nasrullah, Lyudmila Shchukina, Patrick Noel

Subject: Medicine And Pharmacology, Surgery Keywords: bariatric; metabolic; surgery; endoscopic stapler; bleeding; leak

Online: 16 August 2024 (14:22:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1556.v1

Living Longer or Better – Patient’s Choice in Cardiac Surgery Is Gender-Dependent – a Multicenter Study

Britt Hofmann, Epp Rae, Ulrike Puvogel, Mihaela Spatarelu, Salah A. Mohamed, Almoan Bungaran, Sebastian Arzt, Magdalena Laux, Johannes Maximillian Albes, Klaus Matschke, Richard Feyrer, Hans-Hinrich Sievers, Ivar Friedrich, Bernd Niemann, Rolf-Edgar Silber, Andreas Wienke, Andreas Simm

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: patient’s preferences; quality of life; lifespan; gender

Online: 22 August 2023 (10:22:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1816.v1

Deep Learning Approaches for Enhanced Kidney Segmentation: Evaluating U-Net and Attention U-Net with Cross-Entropy and Focal Loss Functions

Rajeev Arora, Anoop Kumar, Arpita Soni

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Index Terms— Deep Learning; Kidney; Magnetic Resonance Imaging; U-Net

Online: 26 August 2024 (11:59:28 CEST)

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Working Paper ARTICLE

Self-Care and Health Related Quality of Life in Patients with Drainage Enterostomy: A Multicenter, Cross Sectional Study.

Eladio J. Collado-Boira, Francisco H. Machancoses, Ana Folch-Ayora, Pablo Salas-Medina, Mª Desamparados Bernat-Adell, Mª Dolores Temprado-Albalat

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: self-care; self-care monitoring; quality of life; stoma care; health promotion; nurse – patient interaction

Online: 12 January 2021 (17:32:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0629.v1

Chemometric Analysis of GC-MS Chemical Profiles and Biological Activities of Three Citrus Essential Oils in Indonesia

Einstivina Nuryandani, Erliana Novitasari, Muhammad Fatih Abdurrahman, Nurul Habibi, Ardiba Rakhmi Sefrienda, Dedy Kurnianto, Jasmadi Jasmadi, Yusuf Andriana

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Citrus species, particle component analysis, essential oils, antioxidant activity, cytotoxicity effects, chemometric analysis

Online: 10 May 2024 (09:11:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1932.v1

Prevalence and Impact of Nutritional Risk and Malnutrition in Gastrointestinal Surgical Oncology Patients: A Prospective, Observational, Multicenter and Exploratory Study

Manuel Durán_Poveda*, Alejandro Suárez-de-la-Rica, Emilia Cancer_Minchot, Julia Ocón_Bretón, Andrés Sánchez_Pernaute, Gil Rodríguez_Caravaca

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: malnutrition; digestive surgery; oncology; gastrointestinal malignancies; prevalence

Online: 27 June 2023 (14:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1477.v1

Cefto-Reallife Study: Real World Data on the Use of Ceftobiprole in a Multicenter Spanish Cohort

Carmen Hidalgo-Tenorio, Ines Pitto Robles, Daniel Arnes Garcia, F Javier Membrill De Novales, Laura Morata, Rosario Menendez, Olga Bravo De Pablo, Vicente Abril Lopez de Medran, Miguel Salavert Lleti, Pilar Vizcarra, Jaime Lora Tamayo, Ana Arnaiz Garcia, Leonor Moreno Nuñez, Mar Masia, Maria pilar Ruiz Seco, Svetlana Sadyrbaeva Dolgova

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Ceftobiprole; sepsis; older; Real-World Data; OPAT

Online: 21 June 2023 (04:10:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0133.v1

Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-Like Lesions: A Multicenter Retrospective Study

Hisaki Aiba, Kunihiro Ikuta, Kunihiro Asanuma, Katsuhisa Kawanami, Satoshi Tsukushi, Akihiko Matsumine, Daisuke Ishimura, Akihito Nagano, Yoji Shido, Eiji Kozawa, Kenji Yamada, Junji Wasa, Hiroaki Kimura, Takao Sakai, Hideki Murakami, Tomohisa Sakai, Tomoki Nakamura, Yoshihiro Nishida

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Neoadjuvant therapy; Soft tissue tumor; Sarcoma; Tail sign; Radiotherapy; Chemotherapy; Hyperthermia; Surgery

Online: 6 July 2021 (11:25:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2527.v1

Updated Risk Assessment of Cannabidiol in Foods based on Benchmark Dose-Response Modeling

Eva Wisotzki, Heike Franke, Constanze Sproll, Stephan G. Walch, Dirk W. Lachenmeier

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: cannabidiol; novel food; health-based guidance value; benchmark dose; risk assessment

Online: 31 July 2024 (09:50:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0512.v1

Orbital Stability Study of the Taiji Space Gravitational Wave Detector

Yu-Yang Zhang, Geng Li, Bo Wen

Subject: Physical Sciences, Space Science Keywords: space-based gravitational wave detection; high precision orbit numerical simulation; analysis of the influence of celestial gravitational field; planetary ephemeris

Online: 8 April 2024 (08:50:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1367.v1

Characteristics and Injury Patterns in Traumatic Brain Injury Related to E-scooter Use in Riga, Latvia: Multicenter Case Series

Agnis Saulitis, Evelina Kocane, Julija Dolgopolova, Ritvars Kalnins, Kaspars Auslands, Kristaps Rancans, Egils Valeinis, Andrejs Millers

Subject: Public Health And Healthcare, Other Keywords: electric scooter; e-scooter; traffic accident; craniofacial trauma; traumatic brain injury; neurosurgery

Online: 25 February 2024 (23:31:46 CET)

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Background and Objectives: In recent years Electronic scooters (E-Scooters) have gained popularity, whether for private use or as a publicly available transportation method. With introduction of these vehicles, reports of E-Scooter related accidents have surged, sparking a public debate and concern. Aim of this study was to analyse epidemiological data, characteristics and severity of traumatic brain injury (TBI) related to E-Scooter accidents. Materials and Methods: This retrospective case series evaluated 28 patients who were admitted to three largest neurosurgery clinics in Riga, Latvia between time period from April to October in two separate years – 2022 and 2023 after an E-Scooter related accident. Data were collected on patient demographics, time of the accident, alcohol consumption, helmet use, type of TBI, other related injuries, treatment and assessment at discharge. Results: A total of 28 patients were admitted with TBI related to E-Scooter use, with median age 30 years (Q1-Q3, 20.25-37.25), four individuals under age of 18, majority (64%) were male. In 23 cases the injury mechanism was fall, in 5 cases collision. None were wearing a helmet at time of injury. Alcohol intoxication was evident in over half of the patients (51.5%), with severe intoxication (>1.2ppm) in 75% cases among them. Neurological symptoms upon admission were noted in 50% of cases. All patients had intracranial trauma - 50% brain contusions, 43% traumatic subdural hematoma, almost 30% - epidural hematoma. Craniofacial fractures were evident in 71% of cases, fractures in other parts of body in 3 patients. 6 patients required emergency neurosurgical intervention. Neurological complications were noted in 2 patients, 1 patient died. Conclusions: E-Scooter related accidents result in a significant number of brain and other associated injuries, with notable frequency linked to alcohol influence and lack of helmet use. Prevention campaigns to raise awareness of potential risks and implementation of more strict regulations should be done.

Preprint ARTICLE | doi:10.20944/preprints202208.0189.v1

Performance of a Chest Radiography AI Algorithm for Detection of Missed or Mislabeled Findings: A Multicenter Study

Parisa Kaviani, Subba R. Digumarthy, Bernardo Bizzo, Bhargava Reddy, Manoj Tadepalli, Preethan Putha, Ammar Jagirdar, Shadi Ebrahimian, Mannudeep K. Kalra, Keith J. Dreyer

Subject: Medicine And Pharmacology, Other Keywords: chest-X ray; sddendum; missed finding; radiology

Online: 10 August 2022 (04:17:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1474.v1

Comparative Analysis of Atezolizumab Plus Bevacizumab and Hepatic Artery Infusion Chemotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter, Propensity Score Study

Ji Hoon Kim, Hee-Chul Nam, Chang Wook Kim, Hee Sun Cho, Jae-Sung Yoo, Ji Won Han, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon, Hyun Yang, Si Hyun Bae, Suho Kim, Jung-Suk Oh, Ho Jong Chun, Chang Ho Chun, Jaegyoon Ahn, Pil Soo Sung

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Hepatocellular carcinoma; Atezolizumab–bevacizumab; Hepatic artery infusion chemotherapy; Overall survival; Progression-free survival

Online: 21 July 2023 (14:00:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1797.v1

Identifying and Analyzing Toxic Behavior in Ecommerce Industry through Reddit Discussions Using BERT and HateBERT

ANOOP KUMAR, ARPITA SONI, Rajeev Arora, Dheerendra Panwar

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: BERT; Games; HateBERT; Mean Behavior; Reddit

Online: 26 August 2024 (08:28:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1632.v1

A Cross-Sectional, Multicenter, Disease-Specific, Health-Related Quality of Life study in Greek Transfusion Dependent Thalassemia Patients

Philippos Klonizakis, Noémi Roy, Ioanna Papatsouma, Maria Mainou, Ioanna Christodoulou, Despina Pantelidou, Smaro Kokkota, Michael Diamantidis, Alexandra Kourakli, Vasilios Lazaris, Dimitrios Andriopoulos, Apostolos Tsapas, Robert J. Klaassen, Efthymia Vlachaki

Subject: Biology And Life Sciences, Life Sciences Keywords: Transfusion-Dependent Thalassemia; Health-Related Quality of Life; Patient Reported Outcomes; disease-specific TranQol questionnaire; Healthcare policy; Thalassemia Unfastructure

Online: 21 December 2023 (13:41:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0531.v2

Dietary Calcium Intake in a Cohort of Individuals Evaluated for Low Bone Mineral Density: a Multicenter Italian Study

Elisa Cairoli, Carmen Aresta, Luca Giovanelli, Cristina Eller, Silvia Migliaccio, Sandro Giannini, Andrea Giusti, Claudio Marcocci, Stefano Gonnelli, Giancarlo Isaia, Maurizio Rossini, Iacopo Chiodini, Marco Di Stefano

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: dietary calcium intake; osteoporosis; fractures; bone mineral density

Online: 14 December 2020 (12:20:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0009.v1

Results of ATOMS (Adjustable Trans-Obturator Male System) in Patients with Prostate Cancer treated with Prostatectomy and Radiotherapy: A Multicenter Study

Javier C Angulo, Carlos Téllez, Alessandro Giammò, Carmen González-Enguita, Sandra Schoenburg, Fabian Queissert, Juliusz Szczesniewski, Raquel González, Antonio Romero, Andreas Gonsior, Francisco Martins, Tiago Antunes-Lopes, Francisco Cruz, Keith Rourke

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Adjustable Trans-Obturator Male System; Post-prostatectomy Incontinence; Adjuvant Radiotherapy; Outcomes; Satisfaction

Online: 3 July 2023 (08:22:49 CEST)

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(1) Background: Treatment of male stress incontinence in patients with prostate cancer treated with radical prostatectomy and adjuvant pelvic radiation is a therapeutic challenge. The efficacy and safety of the adjustable trans-obturator male system (ATOMS) in these patients is not well established, despite the general belief that outcomes are worse than in patients without radiation. (2) Methods: Retrospective multicenter study evaluating patients treated with silicone-covered scrotal port (SSP) ATOMS implant after radical prostatectomy and radiotherapy in nine different institutions between 2016 and 2022. The primary endpoint was dry patient rate, defined as pad-test ≤20 mL/day. The secondary endpoints were complication rate (defined using Clavien-Dindo classification), device removal and self-perceived satisfaction using the Patient Global Impression of Improvement (PGI-I) scale. Wilcoxon rank sum test, Fisher’s exact test and logistic regression were performed using stepwise method with a 0.15 entry and 0.1 stay criteria. (3) Results: 223 patients fulfilled criteria for inclusion, 12 (5.4%) had received salvage prostatectomy after radiation and 27 (12.1%) previous devices for stress incontinence. After ATOMS adjustment, 95 patients (42.6%) were dry and 36 (16.1%) had complications of any grade (grade I, n=20; grade II, n=11; grade III, n=5) during the first 3 months postoperatively. At a mean 36 ± 21 months follow-up the device was explanted in 26 (11.7%) patients. Regarding self-perceived satisfaction with the implant, 105 of 125 patients (84%) considered themselves satisfied (PGI-I 1 to 3). In univariate analysis dryness was associated to younger age (p=.06), primary prostatectomy (p=.08), no previous incontinence surgery (p=.02), absence of overactive bladder symptoms (p=.04), absence of bladder neck stricture (p=.001), no need of surgical revision (p=.008) and lower baseline incontinence severity (p=.0003). Multivariate analysis identified absence of surgical revision (p=.018), absence of bladder neck stricture (p=.05), primary prostatectomy (p=.07) and baseline incontinence severity (p<.0001) were independent predictors of dryness. A logistic regression model was proposed and internally validated. (4) Conclusions: ATOMS is an efficacious and safe alternative to treat male incontinence after radical prostatectomy and adjuvant radiotherapy. Factors predictive of dryness are identified in this complex scenario to allow better patient selection.

Preprint REVIEW | doi:10.20944/preprints202407.1970.v1

Noninvasive, Drug Augmented, Ultra Low Intensity Transcranial Light Photodynamic Treatment of Glioblastoma: LIT-PDT

RICHARD E. KAST, Laura Milla Sanabria, Anton P Kast, Erasmo Barros da Silva Jr

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: 5-ALA; glioblastoma; noninvasive; photodynamic treatment; repurposing

Online: 25 July 2024 (11:05:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1860.v1

AI-Driven Self-Healing Cloud Systems: Enhancing Reliability and Reducing Downtime through Event-Driven Automation

Rajeev Arora, Anoop Kumar, Arpita Soni, Aniruddh Tiwari

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Artificial Intelligence; Cloud System; Engine; OpenStack

Online: 27 August 2024 (11:43:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0666.v1

A Multiparametric Method Improves the Serological Characterization of Inflammatory Bowel Diseases: Preliminary Results from a Multicenter Eastern Europe Study

Nikola Panic, Marco Marino, Goran Hauser, Silvia Jacobsen, Francesco Curcio, Francesco Meroi, Adriana Cifù, Eleonora Castagnaviz, Cinzia Pistis, Giovanni Terrosu, Milutin Bulajic, Salvatore Francesco Vadalà Di Prampero, Dino Tarabar, Irena Krznaric-Zrnic, Gordana Kovacevic, Ivan Ranković, Martina Fabris

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: inflammatory bowel disease; anti-pancreatic antibodies; cell based assay; Crohn’s disease; diagnostic biomarker

Online: 11 October 2023 (14:23:46 CEST)

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Introduction: The serological support to early diagnosis and differential diagnosis of inflammatory bowel diseases (IBD) is actually very limited. In this study we evaluated the performance of a promising multiparametric method including either well established and newly developed biomarkers. Methods: This multicenter retrospective observational study finally enrolled 156 patients with IBD, 100 affected by Crohn’s disease (CD) and 56 by ulcerative colitis (UC) recruited at the Gastroenterology Units of Udine (Italy), Rijeka (Croatia) and Belgrade (Serbia). Twently age-sex matched blood donors (BD) were included as controls. Autoantibody profiles were determined using a mosaic cell and tissue-based indirect immunofluorescence (IIF) method simultaneously investigating: anti-saccharomyces cerevisiae antibodies (ASCA), anti-atypical perinuclear neutrophilic antibodies (P-ANCA), anti-pancreatic antigens antibodies (PAB) and anti-goblet cells antibodies (GAB). Results: PAB (anti-CUZD1 and/or anti-GP2 antibodies) were present in 24 CD patients versus none of UC patients or BD (24% sensitivity, 100% specificity). As regards CD patients, combined positivity of PAB and ASCA (sensitivity 84%, specificity 71.4%) performed better than ASCA alone. Colon involvement (87.5% vs. 60.5%; p=0.014), deep mucosal lesions (58.3% vs. 25.0%; p=0.002) and need for biologic therapies (79.2% vs. 46.1%; p=0.005) were significantly more prevalent in PAB-positive than in PAB-negative CD patients. Multivariate analysis identified PAB positivity (OR=3.67; 95%CI=1.29-10.46) and anti-CUZD1 in particular (OR=3.54; 95%CI=1.08-11.63) as significant risk factors for deep mucosal lesions development in CD. Conclusion: A multiparametric diagnostic approach appears very useful to better characterize IBD patients. PAB, isolated or combined with other autoantibodies, may support both differential diagnosis and selection of CD patients at risk for more severe disease.

Preprint ARTICLE | doi:10.20944/preprints202010.0087.v1

Understanding the Effect of COVID-19 Pandemic on Emergency Surgical Care Delivery in India: A Multicenter Cross-Sectional Study

Anita Gadgil, Geetu Bhandoria, Monty Khajanchi, Bhakti Sarang, Deepa K.V, Prashant Bhandarkar, Monali Mohan, Priyansh Shah, Lovenish Bains, Amulya Rattan, Naveen Sharma, Anurag Mishra, Devi Bavishi, Jaydip Hindocha, Sumit Arora, Ravi Kant, Dnyanesh Belekar, Randeep Wadhavan, Rajeev Satoskar, Ramlal Prajapati, Sudhir Shrivastava, Prashnat Kamble, Niranjan Maydeo, Ashish Gokhale, Nobhojit Roy

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: India; COVID-19 pandemic; Cancellation of surgeries; Global lockdown; Low- and Middle-income country; Emergency surgeries

Online: 5 October 2020 (13:02:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0899.v1

Totally Endoscopic Replacement of the Ascending Aorta and the Aortic Root including the Aortic Valve via Right Mini-Thoracotomy: A Multicenter Study

Marwan Hamiko, Saad Salamate, Maedeh Ayay Nassari, Andre Spaeth, Sami Sirat, Mirko Doss, Mohamed Amer, Miriam Silaschi, Ali El-Sayed Ahmad, Farhad Bakhtiary

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: right minithoracotomy; endoscopic surgery; minimally invasive aortic replacement; minimally invasive aortic root replacement

Online: 15 April 2024 (09:00:07 CEST)

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Background: Recently, minimally invasive access via right-anterolateral mini-thoracotomy (RAMT) has been gaining popularity in cardiac surgery. This approach is also an option for sur-geons performing aortic surgery. Aim of the study is to present our surgical method highlighting the total endoscopic minimally invasive approach via RAMT for replacement of the ascending aorta (AAR) with or without involvement of the aortic root and the aortic valve. Methods: Clini-cal data of 44 patients from three participating institutions with AAR with or without involving the aortic valve or aortic root via RAMT between April 2017 and February 2024 were retrospec-tively analyzed. According to surgical procedure patients were divided in group A with only AAR and group B with concomitant valve or root replacement. Operative time, length of ventila-tion, perioperative outcome, length of intensive care unit (ICU) as well as postoperative hospital stay, and mid- and long-term results were retrospectively analyzed. Results: Mean age was 61.4 ± 10.7 years old with a frequency of male gender (63.6%). Mean cardiopulmonary bypass (CBP) time and aortic cross-clamping time was 94.9 ± 32.5 min. and 63.8 ± 25.9 min., respectively. CPB and aortic clamp time were significantly lower in group A. In the first 24 hours the mean drain-age volume was 790.3 ± 423.6 ml. Re-thoracotomy due to bleeding was zero. Sternotomy could be avoided in all patients. Patients stayed 35.9 ± 23.5 hrs at ICU and were discharged 7.8 ± 3.0 days following surgery from hospital. Mean ventilation time was 5.8 ± 7.6 hrs. All patients survived and 30-day mortality was 0.0%. At a median follow-up time of 18.2 months, all patients were alive. The results were similar in both groups. Conclusions: The full endoscopic RAMT approach with 3D visualization is a safe and feasible technique which can be transferred in the field of aor-tic surgery without compromising surgical quality, postoperative outcomes, or patient safety when performed by an experienced team in a high-volume center.

Preprint ARTICLE | doi:10.20944/preprints202306.0937.v1

Retrospective Analysis of the Correlation of MSI-H/dMMR Status and Response to Therapy for Endometrial Cancer: RAME Study, a Multicenter Experience

Valentina Tuninetti, Luca Pace, Eleonora Ghisoni, Virginia Quarà, Francesca Arezzo, Andrea Palicelli, Vincenzo Dario Mandato, Elena Geuna, Gennaro Cormio, Nicoletta Biglia, Lucia Borsotti, Silvia Gallo, Annamaria Ferrero, Elena Jacomuzzi, Luca Fuso, Jeremy Oscar Smith Pezua Sanjinez, Andrea Puppo, Andrea Caglio, Chiara Rognone, Margherita Turinetto, Giulia Scotto, Massimo Di Maio, Giorgio Valabrega

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Endometrial cancer; microsatellite instability; mismatch repair deficiency; platinum-based chemotherapy

Online: 13 June 2023 (12:27:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0275.v3

An Efficient Gaussian Mixture Model and Its Application to Neural Network

Weiguo Lu, Deng Ding, Fengyan Wu, Gangnan Yuan

Subject: Computer Science And Mathematics, Computer Science Keywords: GMM; Decomposition; Density approximation; Neural Network

Online: 13 August 2024 (08:06:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0010.v1

Machine Learning Algorithms Provide Greater Prediction of Response to Scs Than Lead Screening Trial: A Predictive AI-Based Multicenter Study

Amine Ounajim, Maxime Billot, Lisa Goudman, Pierre-Yves Louis, Yousri Slaoui, Manuel Roulaud, Bénédicte Bouche, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Nihel Adjali, Kevin Nivole, Nicolas Naiditch, Chantal Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: spinal cord stimulation; screening trial; infection; supervised learning; machine learning; predictive modeling; patient outcome

Online: 1 September 2021 (12:05:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0369.v1

One-step nucleic acid amplification (OSNA) of Sentinel Lymph Node in Early Stage Endometrial Cancer: Spanish Multicenter Study (ENDO-OSNA).

M. D. Diestro, A. Berjón, I. Zapardiel, L. Yébenes, I. Ruiz, A. Lekuona, M. Rezola, I. Jaunarena, J. Siegrist, M. Sánchez-Pastor, M. Cuadra, A. Sagasta, I. Guerra, L. I. Lete, F. Roldán, C.-B. Marta, M. J. Boillos, M. J. Cardiel, C. López-de la Manzanara, F. Relea, P. J. Coronado, A. Pascual, M. J. Román, G. Peiró, L. J. Matute, B. Montero, J. C. Muruzábal, R. Guarch, C. Zorrero, A. Calatrava, L. Ribot, I. Costa, A. Hernández, D. Hardisson

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Endometrial cancer; sentinel lymph node; micrometastases; ultrastaging; one-step nucleic acid amplification; OSNA; cytokeratin 19

Online: 16 July 2021 (11:57:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0430.v1

Determination of Risk Factors Associated With Walking Disorders After Anterior Cruciate Ligament Surgery With Hamstring Graft : A Controlled Multicenter Study

Marine Gaignon, Jean Mazeas, Maude Traullé, Amaury Vandebrouck, Pascal Duffiet, Louis Ratte, Florian Forelli

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: anterior cruciate ligament; gait disorder; gait analysis; risk factors

Online: 18 September 2020 (11:17:01 CEST)

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Today, rupture of the anterior cruciate ligament is the most common heavy injury in athletes, but it can also occur in sedentary subjects. Its treatment, always adapted to the lifestyle, age and will of the patient, often remains surgical. However, despite its frequency and universality, there are still walking disorders following the operation. These disorders sometimes persist for several months, or even several years after surgery. The present study is therefore interested in determining the risk factors linked to walking disorders following reconstruction of the anterior cruciate ligament. The objective of this study is to determine what risk factors associated with walking disorders are after reconstruction of the anterior cruciate ligament by hamstring graft. This study focused on factors that may exist at 3 and 6 months postoperatively. Two populations participated in this study, a healthy population and a population having benefited from reconstruction of the anterior cruciate ligament. The operated test group is divided into two subgroups, one with a postoperative period of 3 months and the second at 6 months. All subjects were subjected to the same protocol, their gait on the treadmill was analyzed and evaluated with an Optogait® analysis system. A univariate analysis was carried out first. Then, a multivariate analysis by adjustment method was carried out in order to eliminate the potential confounding factors. The comparison of the results between the populations in the univariate analysis shows an absence of significant results however there are trends. The statistical results of the multivariate analysis showed interactions in the two subgroups of the operated population.In fact, it turns out that at 3 months there is a tendency to worse gait disorders in subjects with a high BMI reflecting overweight, when an associated surgical procedure has taken place on the meniscus, in subjects over 35 years of age and males. On the other hand, at 6 months, the tendency to worsening is visible only in the strata represented by subjects with a BMI corresponding to overweight, as well as in subjects having benefited from a meniscal suture associated with ACL reconstruction. .The results of the present study show that there are certain factors which tend to increase the risk of these walking disorders after reconstruction of the anterior cruciate ligament by hamstring graft, these factors are different depending on the time postoperative.

Preprint ARTICLE | doi:10.20944/preprints201801.0096.v1

Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study

Yalong Dang, Xiao Wang, Yujie Cen, Ying Hong, Ping Huang, Nils Loewen, Chun Zhang

Subject: Medicine And Pharmacology, Ophthalmology Keywords: primary open-angle glaucoma; minimally invasive glaucoma surgery; ab interno trabeculectomy; intraocular pressure; success rate

Online: 11 January 2018 (04:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2187.v1

Third-Order Nonlinear Semi-Canonical Functional Differential Equations: Oscillation via New Canonical Transform

E. Chandrasekaran, George Chatzarakis, R. Sakthivel, E. Thandapani

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: third-order; semi canonical; functional difference equation; oscillation

Online: 29 August 2024 (15:20:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0423.v1

The Effectiveness of a Single Hyaluronic Acid Injection in Improving Symptoms and Muscular Strength in Patients with Knee Osteoarthritis: A Multicenter, Restrospective Study

Domiziano Tarantino, Alfonso Maria Forte, Antonio Picone, Felice Sirico, Carlo Ruosi

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: osteoarthritis; knee osteoarthritis; hyaluronic acid; injection; isokinetic dynamometer

Online: 4 July 2024 (14:42:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2115.v1

Comparison of the Psychological Impact of COVID-19 on Healthcare Workers between 2022 and 2023 in a Romanian COVID-19 Hub Hospital

Monica Muntean, Doina Colcear, Violeta Briciu, Mihaela Lupse, Catalina Crisan, Maria Sidea, Amanda Radulescu

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: COVID-19; healthcare workers; depression; anxiety; stress

Online: 31 May 2024 (09:44:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1450.v1

Thrombin Generation is Associated with Venous Thrombo-embolism Recurrence, but not with Major Bleeding and Death in the Elderly: A Prospective Multicenter Cohort Study

Kristina Vrotniakaite-Bajerciene, Sereina Rütsche, Sara Calzavarini, Claudia Quarroz, Odile Stalder, Marie Méan, Marc Righini, Daniel Staub, Juerg H. Beer, Beat Frauchiger, Joseph Österwalder, Nils Kucher, Christian M. Matter, Marc Husmann, Martin Banyai, Markus Aschwanden, Lucia Mazzolai, Olivier Hugli, Nicolas Rodondi, Drahomir Aujesky, Anne Angelillo-Scherrer

Subject: Medicine And Pharmacology, Hematology Keywords: Thrombin generation; venous thromboembolism; elderly; bleeding; mortality

Online: 21 July 2023 (12:46:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0139.v1

Determinants of Low Birth Weight in the Kenge Health Zone, a (post-) conflict setting, DR Congo: A Multicenter Case–Control Study

Jeannette Muzingu, Francis K Kabasubabo, Pierre Z Akilimali

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: determinants; low birth weight; Kenge

Online: 4 June 2024 (16:25:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0449.v1

Lactate-Based Difference as a Determinant of Outcomes Following Surgery for Type A Acute Aortic Dissection: A LASSO Regression Multicenter Study

Francesco Nappi, Almothana Alzamil, Antonio Salsano, Sanjeet Singh Avtaar Singh, Ivancarmine Gambardella, Francesco Santini, Antonio Fiore, Giacomo Perocchio, Pierre Demondion, Patrick Mesnildrey, Thibaut Schoell, Nicolas Bonnet, Pascal Leprince

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Type A acute aortic dissection; arterial lactate; aortic root replacement; aortic arch repair; valve-sparing aorta replacement; ascending aorta replacement; total arch replacement procedure

Online: 7 September 2023 (03:32:28 CEST)

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Abstract: Type A acute aortic dissection is a serious condition within the acute aortic syndromes that demands immediate treatment. Despite advancements in diagnostic and referral pathways, the survival rate post-surgery currently sits at almost 20%. Our objective was to pinpoint clinical indicators for mortality and morbidity, particularly raised arterial lactate as a key factor for negative outcomes. Methods: All patients referred to the three cardiovascular centres between January 2005 and December 2022 were included in the study. The inclusion criteria required the presence of a lesion involving the ascending aorta, symptoms within 7 days of surgery, and referral for primary surgical repair of TAAAD based on recommendations, with consideration for other concomitant major cardiac surgical procedures needed during TAAAD and retrograde extension of TAAAD. We conducted an analysis of both continuous and categorical variables and utilized predictive mean matching to fill in missing numeric features. For missing binary variables, we used logistic regression to impute values. We specifically targeted early postoperative mortality and employed LASSO regression to minimize potential collinearity of over-fitting variables and variables measured from the same patient. Results: 633 patients were recruited for the study, out of which 449 patients had complete preoperative arterial lactate data. The average age of the patients was 64 years, and 304 patients were male (67.6%). The crude early postoperative mortality rate was 24.5% (110 out of 449 patients). The mortality rate did not show any significant difference when comparing conservative and extensive surgeries. However, malperfusion had a significant impact on mortality [48/131 (36.6%) vs 62/318 (19.5%), p<0.001]. Preoperative arterial lactates were significantly elevated in patients with malperfusion. The optimal prognostic threshold of arterial lactate for predicting early postoperative mortality in our cohort was ≥ 2.6 mmol/L. Conclusion: The arterial lactate concentration in patients referred for TAAAD is an independent factor for both operative mortality and postoperative complications. In addition to mortality, patients with an upper arterial lactate cut-off of ≥2.6 mmol/L face significant risks of VA ECMO and the need for dialysis within the first 48 hours after surgery. To improve recognition and facilitate rapid transfer and surgical treatment protocol, more diligent efforts are required in the management of malperfusion in TAAAD.

Preprint ARTICLE | doi:10.20944/preprints202301.0061.v1

Natural Language Processing Accurately Categorizes Indications, Findings, and Pathology Reports from Multicenter Colonoscopy

Shashank reddy Vadyala

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Neural Network; Machine Learning; Natural Language Processing (NLP); Text Mining; Sentence Classification; Colorectal Cancer; Clinical Information.

Online: 4 January 2023 (03:48:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0145.v1

Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study

Masaya Morimoto, Yuma Yokoya, Kikuaki Yoshida, Hideki Kosako, Yoshikazu Hori, Toshiki Mushino, Shinobu Tamura, Reiko Ito, Ryosuke Koyamada, Takuya Yamashita, Shinichiro Mori, Nobuyoshi Mori, Sachiko Ohde

Subject: Medicine And Pharmacology, Hematology Keywords: febrile neutropenia; chemotherapy; diffuse large B-cell lymphoma; outcomes; multivariate logistic regression model

Online: 2 November 2023 (10:24:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1767.v1

Usefulness of Tumor Marker Score for Prediction of Prognosis in Hepatocellular Carcinoma Patients Treated with Atezolizumab plus Bevacizumab: A Multicenter Retrospective Study

Kazunari Tanaka, Kunihiko Tsuji, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hidekatsu Kuroda, Yutaka Yata, Hideko Ohama, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Keisuke Yokohama, Hiroki Nishikawa, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Takashi Kumada

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; tumor marker; atezolizumab plus bevacizumab; prognosis; predictive model

Online: 26 June 2023 (09:42:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0034.v1

Safety and Effectiveness of Naproxen 220mg + Paracetamol 300mg + Pamabrom 25mg Fixed Dose Combination in Women With Premenstrual Syndrome: A Post-marketing, Open-Label, Prospective, Multicenter, Observational Study

Alvaro E. Peña-Jiménez, Omar Benítez-Aguilar, Jesús E. Villegas, Mario González-de la Parra, Livan Delgado-Roche

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: pain; non-steroidal anti-inflammatory drugs; dysmenorrhea; edema; inflammation; over-the-counter drugs

Online: 1 August 2023 (14:21:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0186.v1

Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study

Arturo Cuomo, Marco Cascella, Cira Antonietta Forte, Sabrina Bimonte, Gennaro Esposito, Stefano De Santis, Luigi Cavanna, Flavio Fusco, Mario Dauri, Silvia Natoli, Marco Maltoni, Alessandro Morabito, Rocco Domenico Mediati, Vito Lorusso, Sandro Barni, Giampiero Porzio, Sebastiano Mercadante, Anna Crispo

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: breakthrough cancer pain; cancer-associated pain; cancer; health-related quality of life; sleep disorders; transmucosal fentanyl

Online: 14 February 2020 (03:36:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2151.v1

Combining Ability of Capsicum annuum Hybrid for Antioxi-Dant Activities, Polyphenol Content, α-Glucosidase Inhibitory, Yield, and Yield Components

Muhamad Syukur, Awang Maharijaya, Waras Nurcholis, Arya Widura Ritonga, Arya Yuda Pangestu, Andi Nadia Nurul Lathifa Hatta, Muhammad Ridha Alfarabi Istiqlal, Abdul Hakim, Zulfikar Damaralam Sahid

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: α -glucosidase inhibition; antioxidant; combining ability; heterotic effect; polyphenol content

Online: 30 August 2024 (10:56:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0068.v1

Effectiveness of Public and Co-operative Health Insurance Models in Nepal: A Concurrent Mixed Study

Chhabi Ranabhat, Chun-Bae Kim, Myung-Bae Park

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: community-based health insurance; cooperative; benefit package; social inclusion; healthcare; Nepal

Online: 6 August 2016 (11:54:03 CEST)

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Background: Health insurance (HI) run by government is providing health care service to large population. Due to poor accountability, participation and sustainability, cooperative health insurance is becoming more popular and effective in low and middle income and some high-income countries too. In Nepal, there are public and cooperative HI is in practice. The aim of this study is to compare the effectiveness of public (government) and cooperative HI in relation to benefit packages, population coverage, inclusiveness, health care utilization, and promptness for treatment in these two health insurance models in Nepal. Method: This is an institution based concurrent mixed study consists of qualitative and quantitative variables from public and cooperative groups. We included all public HI operated by government hospitals and cooperatives groups those purchased hospital service in contract. Two separate study tools were applied to access the effectiveness of insurance models. The key questions were asked for the representatives of government and private health insurance. The numeric information consisted of in quantitative data and subjective response was included in qualitative approach. Descriptive statistics and Mean Whitney U test was applied in numeric data and qualitative information were analyzed by inductive approach Results: The study revealed that new enrolment was not increased, health care utilization rate was increased and the benefit package was almost same in both groups. The overall inclusiveness was higher for the government HI, but enrolment from the religious minority, proportion of negotiated amount during treatment were significantly higher (p<0.05). During illness, the response time to reach hospital was significantly faster in cooperative health insurance than government health insurance. Qualitative findings showed that level of participation, accountability, transparency and recording system was better in cooperative health insurance than public. Conclusion: Cooperative HI could be more sustainable and accountable to the community for all; low, middle and high-income countries.

Preprint ARTICLE | doi:10.20944/preprints202408.1251.v1

Psychological Cognitive Mechanism of Residents Under the Background of the Renewal of Suburban Historical and Cultural Villages

Meng Li, Tiehong Wu, Linsheng Zhong, Chengcai Tang, Jingwen Wang, Ruhan Yi

Subject: Social Sciences, Cognitive Science Keywords: suburban; historical and cultural villages; tourism effects; residents; psychological cognitive mechanism

Online: 19 August 2024 (10:45:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1412.v1

Comparison of New Inflammatory Marker Scoring Systems and Conventional Inflammatory Markers in Patients Over 65 Years of Age Admitted to the Intensive Care Unit: A Multicenter Retrospective Cohort Study

Özlem Çakin, Arzu Karaveli, Melike Yüce Aktepe, Ayça Gümüş, Özlem Esra Yildirim

Subject: Medicine And Pharmacology, Internal Medicine Keywords: intensive care unit; inflammatory markers; scoring systems; geriatric patient

Online: 22 May 2024 (15:29:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0398.v1

Mitomycin C as an Anti-persister Strategy Against Klebsiella Pneumoniae: Toxicity and Synergy Studies

Olga Pacios, Soraya Herrera-Espejo, Lucía Armán, Clara Ibarguren-Quiles, Lucia Blasco, Inés Bleriot, Laura Fernández-García, Concha Ortiz-Cartagena, Maria Paniagua, Antonio Barrio Pujante, Belen Aracil, Jose Miguel Cisneros, Maria Eugenia Pachon, María Tomás

Subject: Biology And Life Sciences, Virology Keywords: persistence; K. pneumoniae; repurposing; mitomycin C; lytic phage; cytotoxicity

Online: 6 August 2024 (12:44:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0477.v1

Clinical Impact of Digitalis Therapy in a Large Multicenter Cohort of CRT‐Recipients

Julia W Erath, Nikolett Vigh, Balázs Muk, Carsten W Israel, Badder Kattih, Dávid Pilecky, Gabor Z Duray, Mate Vamos

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: digitalis; digoxin; digitoxin; cardiac‐resynchronization‐therapy; CRT‐D; defibrillator; congestive heart failure; mortality; CRT response

Online: 7 November 2023 (14:18:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0803.v1

Lumbar Spine Coronal Balance Parameters as a Predictor of the Rehabilitation Management Outcomes in Patients With Radiculopathy Due to Lumbar Disc Herniation: A Multicenter Prospective Cohort Study

Yaser AH Aljallad, Ibrahim M. Moustafa, Mohamed Badr, Nouran Hamza, Paul A. Oakley, Deed E. Harrison

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: low back pain; leg pain; disc herniation; clinical trial; radiography

Online: 13 October 2023 (02:57:31 CEST)

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A multicenter, prospective cohort study conducted in 5 physiotherapy clinics in the UAE from January 2021 to March 2023 to assess coronal lumbar spine radiographic parameters as a predictor of conservative therapy outcomes in patients suffering from low back and leg pain due to lumbar disc herniation (HNP). Ninety patients (mean age 44 yrs., 54% male) with lumbar HNP underwent conservative therapy. All participants received lumbar spine MRI and radiography to assess spine alignment. Interventions included specific exercises, diathermy, traction, education, a home-based exercise pro-gram, and medications. Detailed demographic data was collected. Follow-up was 6-months after discharge. A successful outcome was based on a minimum of the following four outcomes: (1) reduction of pain by 17.5 points (0–100 NRS); (2) fatigue reduction by 7.5 points; (3) distress reduction by 5 points; and (4) interference reduction by 9.5 points. At 6-month follow-up it was found that patient age, education, and radio-graphic determined lumbosacral angle measures significantly affected the odds of a successful outcome. Increasing age 1-year significantly decreased the odds of success of improving pain, fatigue (OR = 0.85, p = 0.016) and interference scores (OR = 0.89, p = 0.042) by 15%, 15%, and 11% respectively. Lower education significantly increased the odds of success for improving pain, fatigue, and interference by 26.18, 26.18, and 7.5 (p = 0.006, = 0.006, and = 0.029 respectively). Increasing (worsening) the radiographic lumbosacral angle by each 1° significantly reduced the odds of success for improving pain, fatigue, distress, and interference by 3.52, 3.52, 27.99, and 2.55, respectively (p < 0.001, < 0.001, = 0.003, = 0.001). Our findings indicate that younger age, less education, and better coronal radiological lumbar spine alignment all had a substantial impact on the likelihood of success of 6-month outcomes in patients suffering from chronic lower back pain and radiculopathy due to HNP.

Preprint ARTICLE | doi:10.20944/preprints202305.1721.v1

A Japanese Prospective, Multicenter Study of Colonic Stenting for Palliation Using a High Axial Force Self-Expandable Metal Stent for Malignant Large Bowel Obstruction in 200 Patients

Rei Ishibashi, Takashi Sasaki, Hiroyuki Isayama, Takeaki Matsuzawa, Toshio Kuwai, Tomonori Yamada, Shuji Saito, Masafumi Tomita, Toshiyasu Shiratori, Satoshi Ikeda, Hideki Kanazawa, Mitsuhiro Fujishiro, Iruru Maetani, Yoshihisa Saida

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: axial force; chemotherapy; malignant colorectal obstruction; palliation; self-expandable metal stent

Online: 25 May 2023 (03:11:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1252.v1

Comparison of BMD and TBS Scores in Patients with and without Vertebral Fractures and Thyroid Cancer with Long-Term TSH-Suppressed Therapy

Federico Hawkins Carranza, Cristina Martin-Arriscado Arroba, Maria begoña Lopez Alvarez, Soledad Librizzi, Guillermo Martinez Diaz-Guerra

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: differentiated thyroid cancer; TSH suppression therapy; bone mineral density; Trabecular Bone Score; levothyroid

Online: 21 March 2024 (12:47:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0920.v1

Microbial Detoxification of Sediments Underpins Persistence of Zostera marina Meadows

Yuki Nakashima, Takumi Sonobe, Masashi Hanada, Goushi Kitano, Yoshimitsu Sonoyama, Katsumi Iwai, Takashi Kimura, Masataka Kusube

Subject: Environmental And Earth Sciences, Oceanography Keywords: Zostera marina; Eelgrass meadows; Blue carbon; H2S detoxification; Sulfur-oxidizing bacteria; Sulfur-reducing bacteria; Chromatiales

Online: 15 April 2024 (18:05:04 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202405.0204.v1

Endoscopic Picture in Chronic Rhinosinusitis Associated with Gerd

Kalamkas T. Sagandykova, Natalia M. Papulova, Talapbek M. Azhenov, Aliya Darbekova, Jerome R. Lechien

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Chronic rhinosinusitis; Endoscopic picture; Gastroesophageal reflux disease; Laryngopharyngeal reflux; Rhinosinusitis; Nasopharyngeal reflux. The Reflux Symptom Index (RSI); The Reflux Symptom Score (RSS)

Online: 6 May 2024 (08:47:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0222.v1

Biocompatibility and Effectiveness of a Novel Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial

Luís Azevedo, André Correia, Carlos F. Almeida, Pedro Molinero-Mourelle, Maria Correia, Jaime Del Río Hisghsmith

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Prosthodontics; Edentulism; Elderly; Complete Denture; Candida Albicans; Antimicrobial activity

Online: 8 February 2021 (21:38:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0018.v1

Restoring Upper Limb Function by Combined Repetitive Transcranial Magnetic Stimulation and Occupational Therapy in Patients with Chronic Stroke: A Stratified Analysis Factoring the Severity of Motor Paralysis using a Multicenter Cohort Study Database

Daigo Sakamoto, Toyohiro Hamaguchi, Kai Murata, Hiroshi Ito, Yasuhide Nakayama, Masahiro Abo

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: stroke; occupational therapy; activities of daily living; goal setting; transcranial magnetic stimulation: upper extremity; motor paralysis

Online: 1 November 2022 (04:46:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1110.v1

Anti-aging Integrative Therapy Effects: A Clinical Study

Alok Sharma, Hemangi M. Sane, Nandini Gokulchandran, Pooja P. Kulkarni, Heena Sayed, Divyangi Sawant, Pallavi Khubchandani, Anushka Dongaonkar

Subject: Biology And Life Sciences, Aging Keywords: Telomere length; Anti-aging treatment; HBOT; Ozone therapy; Colon hydrotherapy; Multivitamins

Online: 15 July 2024 (04:57:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1359.v1

Anti-Herpetic Activity of Killer Peptide (KP): An In Vitro Study

Arianna Sala, Francesco Ricchi, Laura Giovati, Stefania Conti, Tecla Ciociola, Claudio Cermelli

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Antimicrobial peptides; HSV-1; HSV-2; antivirals; Killer Peptide (KP)

Online: 19 September 2024 (08:45:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1981.v1

Study on Structure Damage Identification Methods

Yuantian Qin, Jiahao Ma

Subject: Engineering, Mechanical Engineering Keywords: damage identification; RGA; INFO algorithm; dynamic response transfer-ratio

Online: 28 August 2024 (11:55:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0794.v1

Comparison of Survival Outcomes between Radical Antegrade Modular Pancreato-Splenectomy and Conventional Distal Pancreato-Splenectomy for Pancreatic Body and Tail Cancer: Korean Multicenter Propensity Score Match Analysis

Hee Joon Kim, Sang Hyun Shin, Jaewoo Kwon, Huisong Lee, Hongbeom Kim, Sung Hyun Kim, Jae Do Yang, Woohyung Lee, Jun Suh Lee

Subject: Medicine And Pharmacology, Surgery Keywords: pancreatic neoplasm; pancreatectomy; survival; prognosis

Online: 13 March 2024 (16:07:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0698.v1

A Comparative Study of Susceptibility and Hazard for Mass Movements Applying Quantitative Machine Learning Techniques. Case Study: Northern Lima Commonwealth, Peru

Edwin Noe Badillo-Rivera, Manuel Daniel Olcese Huerta, Ramiro Santiago Chirinos, Teófilo Ivan Poma Inche, Neftalí Euclides Muñoz Fernandez, Carlos Alberto Rojas-León, Teodosio Juan Chávez Campos, Luz de Fátima Eyzaguirre Gorvenia, César Augusto Rodriguez Aburto, Fernando José Oyanguren Ramírez

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: mass movement, weight evidence, principal component analysis, machine learning.

Online: 10 May 2024 (14:15:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0353.v1

A Study on Control of Dog Food Quality, Safety and Health

Ka Man Ma, Tsz Him Chan, Shu Lun Mak, Wai Fan Tang, Wai Ying Chak, Chi Chung Lee, Chun Yin Li

Subject: Biology And Life Sciences, Life Sciences Keywords: pet foods; food safety; dog food; dry dog food; semi-moist dog food; moist dog food; regulations

Online: 7 May 2024 (10:54:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1171.v1

The Regenerate Study: A Non-randomised Feasibility Study of an Intervention to Reduce Anticholinergic Burden in Older Patients

Athagran Nakham, Christine Bond, Moira Cruickshank, Rumana Newlands, Phyo Kyaw Myint

Subject: Public Health And Healthcare, Other Keywords: Anticholinergic burden; Deprescribing; Feasibility study

Online: 17 September 2024 (05:05:28 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202304.0775.v1

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Reports

Gennai Alessandro, Monica Baldessin, Fabrizio Melfa, Bruno Bovani, Alessandra Camporese, Barbara Claysset, Mattia Colli, Alberto Diaspro, Rosalba Russo, Placido Strano, Daniele Bollero, Guido Capparè, Alessandro Casadei, Giovanni Gallo, Domenico Piccolo, Giovanni Salti, Piero Tesauro

Subject: Medicine And Pharmacology, Dermatology Keywords: facial rejuvenation; Stromal Vascular Fraction; adipose derived mesenchymal stem cells; autologous adipose tissue graft; Superficial Enhanced Fluid Fat Injection; clinical regeneration applications

Online: 23 April 2023 (05:01:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0135.v1

Phylogeny of Land Plants: a Case Study of Deep-Time Reconstructions

Yin-Long Qiu, Brent D. Mishler

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: land plants; phylogeny; morphology; sequence characters; genome structural characters; congruence

Online: 2 July 2024 (00:22:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1579.v1

Surgical Site Infections: A Study on Application of the Guidelines and Risk Factors

Cristina Genovese, Caterina Elisabetta Rizzo, Elvira Ventura Spagnolo, Giovanni Genovese, Paola Tripodi, Isabella La Spina, Sabrina Sortino, Francesco Loddo, Bruno Romeo, Linda Bartucciotto, Raffaele Squeri

Subject: Public Health And Healthcare, Health Policy And Services Keywords: surgical site infections; healthcare

Online: 20 September 2024 (15:00:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1530.v1

A Comparative Study of Different CFD-codes for Fluidized Beds

Parindra Kusriantoko, Per Fredrik Daun, Kristian Etienne Einarsrud

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: Fluidized beds; CFD; Multiphase Flow; Fluidization; Fluent; OpenFOAM; MFiX

Online: 23 May 2024 (12:35:33 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202404.1687.v1

Using Machine Learning to Detect Bixonimania: An Early Feasibility Study

Lazljiv Izgubljenovic, Nao Tippet, Betsy Thurberg, Andi Deep

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Bixonimania; Machine Learning

Online: 26 April 2024 (10:49:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1229.v1

Regenerative Potential of Demineralized Dentin-Derived Graft Material in Rabbit Calvaria: A Histomorphometric Study

Bounghoon Lee, Hyunsuk Choi, Dong-Seok Sohn

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: guided bone regeneration; rabbit calvaria; histology; dentin-derived matrix

Online: 20 May 2024 (15:59:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1352.v1

Oral Iron Absorption of Ferric Citrate Hydrate and Hepcidin-25 in Hemodialysis Patients: A Prospective, Multicenter, Observational Riona-Oral Iron Absorption Trial

Naohisa Tomosugi, Yoshitaka Koshino, Chie Ogawa, Kunimi Maeda, Noriaki Shimada, Kimio Tomita, Shoichiro Daimon, Tsutomu Shikano, Kazuyuki Ryu, Toru Takatani, Kazuya Sakamoto, Satonori Ueyama, Daisuke Nagasaku, Masato Nakamura, Shibun Ra, Masataka Nishimura, Chieko Takagi, Yoji Ishii, Noritoshi Kudo, Shinsuke Takechi, Takashi Ishizu, Takamoto Yanagawa, Masamichi Fukuda, Yutaka Nitta, Takayuki Yamaoka, Taku Saito, Suzuko Imayoshi, Momoyo Omata, Joji Oshima, Akira Onozaki, Hiroaki Ichihashi, Yasuhisa Matsushima, Hisahito Takae, Ryoichi Nakazawa, Koichi Ikeda, Masato Tsuboi, Keiko Konishi, Shouzaburo Kato, Maki Ooura, Masaki Koyama, Tsukasa Naganuma, Makoto Ogi, Shigeyuki Katayama, Toshiaki Okumura, Shigemi Kameda, Sayuri Shirai

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: oral iron absorption; ferric citrate hydrate; hemodialysis; hepcidin-25; iron shift

Online: 18 August 2023 (11:20:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0498.v1

Treatment of the Fractures of the Humeral Surgical Neck: MIROS versus Intramedullary Nailing. A Retrospective Study

Michelangelo Palco, Gabriele Giuca, Domenico Fenga, Ilaria Sanzarello, Matteo Nanni, Danilo Leonetti

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Proximal Humerus Fractures; MIROS System; Intramedullary Nailing; Orthopedics; Retrospective Study

Online: 6 September 2024 (09:42:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0162.v1

Effectiveness of Smartphone App for the treatment of Pediatric Obesity: A Prospective Longitudinal Study

Giuseppina Rosaria Umano, Mariapia Masino, Grazia Cirillo, Giulia Rondinelli, Francesca Massa, Giuseppe Salvatore R.C. Mangoni di Santo Stefano, Anna Di Sessa, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Pietro Buono

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: obesity 1; treatment 2; m-Health 3

Online: 2 August 2024 (12:58:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1520.v1

Self-medication practices among adult population in Bangladesh: A cross-sectional study

Nitai Roy, Md. Nazrul Islam, Md. Shahjalal, Aysha Siddiky, Sultan Mahmud Imran, Md. Aktarujjaman, Md. Mobarak Hossain, Bryan T. Rogers, Kamal Krishna Biswas, Ekhtear Hossain

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Self-medication; Prevalence; Risk factors; Bangladesh

Online: 27 February 2024 (09:21:32 CET)

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Background: The practice of self-medication is common worldwide and is an important component of medical self-care. However, the practice can be dangerous and is linked to various risks for the patients and the entire community. This study aimed to estimate the prevalence and factors associated with self-medication among Bangladeshi adults. Methods: A cross-sectional survey was conducted between April and June 2021 among Bangladeshi adults (aged >19 years) using convenient sampling. A total of 1320 data were collected through face-to-face interviews using a standardized questionnaire. Multivariable logistic regression analysis was used to identify factors associated with self-medication practice (SMP). Results: Overall, 41% of adults in our survey reported SMP. The most common illnesses that prompted SMP were common cold/flu (66.4%), gastric problems (65%), and headache (64.4%). The most frequent reasons for SMP were to get better services (30.59%), perceive SMP without side effects (23.28%), and save time with effectiveness (14.56%). Potential risk factors included 10 years (AOR = 1.91; 95% CI: 1.04 - 3.50) and >12 years of schooling (AOR = 5.03; 95% CI: 2.27 - 11.15), being a businessman (AOR = 4.64; 95% CI: 1.74 - 12.37), having ≤6 family members (AOR = 2.13; 95% CI: 1.40 - 3.24), being a member of a social group (AOR = 1.53; 95% CI: 1.10 - 2.12), a health status check after every six months (AOR = 1.52; 95% CI: 1.08 - 2.13), and current ill-health (AOR = 1.41; 95% CI: 1.06 - 1.87). Protective factors identified included ≤30 years of age (AOR = 0.40; 95% CI: 0.17 - 0.93), and practice of modern (AOR = 0.39; 95% CI: 0.22- 0.69) and herbal (AOR = 0.45; 95% CI: 0.21- 0.97) healing types. Conclusion: More than one-third of the study participants reported practicing self-medication. Increasing the community’s awareness of the extreme consequences of SMP and not just the average experience might sway individuals away from SMP, and implementing strict jurisdiction could be a way to minimize the SMP.

Preprint ARTICLE | doi:10.20944/preprints202408.1209.v1

Linezolid Adsorption on the Filters during Continuous Renal Replacement Therapy: In Vitro Study

Krzysztof Nosek, Milena Samiec, Hubert Ziółkowski, Paulina Markowska-Buńka, Mirosław Czuczwar, Michał Borys, Dariusz Onichimowski

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: adsoprtion; linezolid; continous renal replacement therapy; dialysis filter

Online: 16 August 2024 (07:14:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0227.v1

Industrialization in Construction Companies – a Benchmark Study on Manufacturing Companies

Solmaz Mansoori, Janne Härkönen, Harri Haapasalo, Petteri Annunen

Subject: Engineering, Architecture, Building And Construction Keywords: predefined products; predefined processes; data management; industrialized construction

Online: 3 April 2024 (13:15:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1445.v1

A Review on Watershed Environment Study with Lake Sediment Records in China

Minqiao Li, Guoping Tang, Huasheng Huang

Subject: Environmental And Earth Sciences, Paleontology Keywords: literature review; lake sediments; lake ecosystems; paleoenvironment; paleoclimate; paleovegetation

Online: 25 March 2024 (08:14:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1708.v1

Modelling Lysosomal Storage Disorders in an innovative way: Establishment and Characterization of Stem Cell Lines from Human Exfoliated Deciduous Teeth of Mucopolysaccharidoses Type II Patients

Sofia Carvalho, Juliana Inês Santos, Luciana Moreira, Ana Joana Duarte, Paulo Gaspar, Hugo Rocha, Marisa Encarnação, Diogo Ribeiro, Matilde Barbosa Almeida, Mariana Gonçalves, Hugo David, Liliana Matos, Olga Amaral, Luísa Diogo, Sara Ferreira, Constança Santos, Esmeralda Martins, Maria João Prata, Luís Pereira de Almeida, Sandra Alves, Maria Francisca Coutinho

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Mucopolysaccharidosis type II; Disease Modelling; in vitro models; induced Pluripotent Stem Cells (iPSCs); Dental Pulp Stem Cells (DPSCs); SHED: Stem cells from Human Exfoliated Deciduous teeth (SHEDs)

Online: 29 February 2024 (13:03:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0975.v1

Machine Learning Approaches for Stroke Risk Prediction: Findings from the Suita Study

Thien Vu, Yoshihiro Kokubo, Mai Inoue, Masaki Yamamoto, Attayeb Mohsen, Agustin Martin-Morales, Takao Inoué, Research Dawadi, Michihiro Araki

Subject: Public Health And Healthcare, Other Keywords: Stroke; supervised machine learning; unsupervised machine learning; Logistic Regression; Random Forest; Support Vector Machine (SVM); eXtreme Gradient Boost (XGBoost); Light Gradient Boosted Machine (Light-GBM); K-prototype clustering; Shapley Addictive ExPlanations (SHAP)

Online: 14 May 2024 (13:25:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0336.v1

A Study of Microplastics in the Freshwater Systems around Dhaka

Md Zahidul Alam, Md Rifat Hossain, Khan Humayra Hafsa Medha, Dr.Md Mujibur Rahman

Subject: Environmental And Earth Sciences, Pollution Keywords: microplastics; microplastic pollution; water pollution; rivers of Dhaka; Bangladesh

Online: 6 March 2024 (09:23:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0961.v1

Cigarette Smoke Exposure and microRNA in Human Alveolar Macrophages: A Pilot Study

Davida Mirra, Renata Esposito, Giuseppe Spaziano, Concetta Rafaniello, Francesca Panico, Antonio Squillante, Maddalena Falciani, Fiorentina Roviezzo, Luca Gallelli, Erika Cione, Bruno D’Agostino

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: microRNAs; alveolar macrophages; cigarette smoke; COPD; lung cancer

Online: 14 May 2024 (14:57:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1370.v1

Mycologists and Virologists Align: Proposing Botrytis cinerea for Global Mycovirus Study

Mahmoud E. Khalifa, María A Ayllón, Lorena Rodriguez-Coy, Kim M Plummer, Anthony R Gendall, Kar Mun Chooi, Jan A.L. van Kan, Robin M MacDiarmid

Subject: Biology And Life Sciences, Virology Keywords: model system; Botrytis cinerea; mycovirus

Online: 21 August 2024 (02:28:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0205.v1

A Study on the Man-Hour Prediction in Structural Steel Fabrication

Zhangliang Wei, Zhigang Li, Renzhong Niu, Peilin Jin, Zipeng Yu

Subject: Engineering, Mechanical Engineering Keywords: Man-hour prediction; RFR; steel fabrication; ML; predictive system

Online: 6 May 2024 (08:46:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1427.v1

Study of Femtosecond Laser Ablation and Polishing Process on 4H-SiC Substrate

Ziqiang Zhao, Lin Zhao, Yun Peng

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: femtosecond laser; simulation; surface polish

Online: 22 May 2024 (11:07:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1014.v1

Consumption of Tap Water and Sociodemographic-Associated Characteristics: A Nationwide Cross-Sectional Study.

Jacopo Dolcini, Manuela Chiavarini, Elisa Ponzio, Giorgio Firmani, Marcello Mario D'Errico, Pamela Barbadoro

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Safe Water; Public Health; Sociodemographic characteristics; Environmental Health; Health out-comes

Online: 19 February 2024 (08:01:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.2015.v1

Antonio Mazzotti, Laura Langone, Simone Ottavio Zielli, Elena Artioli, Alberto Arceri, Lorenzo Brognara, Francesco Traina, Cesare Faldini

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Subtalar arthrorisis; Pediatric; flatfoot; hallux valgus angle; Intermetatarsal angle

Online: 30 April 2024 (15:02:54 CEST)

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Introduction: Subtalar Arthroereisis (STA) is a surgical intervention for pediatric flexible flatfoot (PFF), primarily targeting hindfoot alignment by limiting excessive subtalar eversion. However, its effects on forefoot parameters remain underexplored. This study aims to investigate radiological changes following STA in pediatric patients. Materials and Methods: A retrospective analysis was conducted on consecutive patients treated with STA for PFF. First ray-related angles, including Hallux Valgus Angle (HVA) and Inter-Metatarsal Angle (IMA), alongside hindfoot radiological parameters such as Meary, Calcaneal Pitch, and Costa Bartani angles, were assessed. Subgroup analysis by gender was performed, and correlations between demographic and pre-operative radiological parameters were examined. Results: Forty-one patients (81 feet) with a mean age of 11.6 years were included, with a mean follow-up duration of 6.4 months. No significant differences were observed in first ray-related an-gles pre- and post-operatively, with mean IMA changing from 7.97° to 7.18° and mean HV angles from 9.51° to 8.66°. Noteworthy improvements were seen in flat foot angles, including Meary, Calcaneal Pitch, and Costa Bartani angles, postoperatively. Age subgroup analysis revealed similar trends in IMA and HVA changes between Group A (operated before peak growth) and Group B (operated later). Higher preoperative angles tended to improve, while lower preoperative IMA and HVA tended to worsen postoperatively, all remaining within normal ranges. Conclusion: STA showed positive radiological outcomes for PFF treatment, while negligible changes in first ray-related angles were observed. Age subgroup analysis indicated similar trends regardless of operation timing. Higher preoperative angles tended to improve, while lower preoperative angles tended to worsen postoperatively, despite all falling within non-pathological ranges. Further re-search is warranted to confirm this correlation.

Preprint ARTICLE | doi:10.20944/preprints202312.1615.v1

Ultrasound-Assisted, Catheter-Directed Thrombolysis for Acute Intermediate/High Risk Pulmonary Embolism: Design of the Multicenter USAT IH-PE Registry and Preliminary Results

Claudia Colombo, Nicolò Capsoni, Filippo Russo, Mario Iannaccone, Marianna Adamo, Giovanna Viola, Ilaria Emanuela Bossi, Luca Villanova, Chiara Tognola, Camilla Curci, Francesco Morelli, Rossella Guerrieri, Lucia Occhi, Giuliano Chizzola, Antonio Rampoldi, Francesco Musca, Giuseppe De Nittis, Mario Galli, Giacomo Boccuzzi, Daniele Savio, Davide Bernasconi, Luciana D’Angelo, Andrea Garascia, Alaide Chieffo, Matteo Montorfano, Fabrizio Oliva, Alice Sacco

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: pulmonary embolism; ultrasound assisted; catheter-directed thrombolysis; pulmonary hypertension

Online: 21 December 2023 (06:19:38 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202406.0239.v1

Endoscopic Features of Chronic Rhinosinusitis in Patients with Gastoesophageal Reflux Disease

Kalamkas Sagandykova, Nataliya Papulova, Talapbek Azhenov, Aliya Darbekova, Bayan Aigozhina, Jerome R. Lechien

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Endoscopic picture; Laryngopharyngeal reflux; Rhinosinusitis; Nasopharyngeal reflux; The Reflux Symptom Index; The Reflux Symptom Score

Online: 5 June 2024 (10:56:24 CEST)

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Chronic rhinosinusitis (CRS) is a complex inflammatory condition affecting the nasal and paranasal sinus mucosa. Gastroesophageal reflux disease (GERD) has been implicated as a potential exacerbating factor in CRS, but the specific endoscopic features of nasopharyngeal pathology in this context remain poorly understood. Background and Objectives: CRS is a multifactorial disease with various underlying etiologies, including inflammation, anatomical factors, and environmental triggers. While GERD has been suggested as a potential contributor to CRS, the specific endoscopic features indicative of nasopharyngeal pathology in CRS patients with GERD symptoms have not been clearly elucidated. Our aim is to identify specific endoscopic features of nasopharyngeal pathology in patients with CRS associated with GERD symptoms, and to propose a method for assessing the influence of GERD on the mucosal layer of the nose and nasopharynx. Materials and Methods: We conducted a cross-sectional observational study involving 521 adult patients presenting with symptoms suggestive of CRS. From this cohort, 95 patients with the highest scores on the Reflux Symptom Index (RSI) and Reflux Symptom Score-12 (RSS-12) questionnaires were selected as the main group. Endoscopic examinations were performed to assess the nasal and nasopharyngeal mucosa. Results: Our study revealed significant alterations in the nasopharyngeal mucosa of patients with CRS associated with GERD symptoms. Increased vascularity of the nasopharyngeal mucosa was observed in 91 patients (95.7%), while hypertrophy was noted in 83 patients (87.4%). Mucus was present in the nasopharynx of 77 patients (81.1%), exhibiting varying characteristics of color and consistency. Asymmetric hypertrophy of the oropharyngeal mucosa was noted in 62 patients (65.3%). Conclusions: We propose a method for assessing the influence of GERD on the mucosal layer of the nose and nasopharynx, which may aid in diagnostic and management decisions. Further research is warranted to explore the potential impact of GERD symptoms on the course and severity of CRS exacerbations.

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