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Preprint COMMUNICATION | doi:10.20944/preprints202308.0827.v1

Assessment of NADH/NAD+ Redox Imbalance in Psoriatic Lesions Using the FMSF Technique: Therapeutic Aspects

Jerzy Gebicki, Tomasz Filipiak, Andrzej Marcinek, Anna Woźniacka

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; NADH/NAD+ redox imbalance; NADH fluorescence; FMSF technique

Online: 10 August 2023 (07:12:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0030.v1

ZIKA Virus Envelope Protein Forms Disulfide Bond-Dependent Polymers: Evidence for A Redox Imbalance during Infection

Grégorie Lebeau, Jonathan Turpin, Etienne Frumence, Daed El Safadi, Wissal harrabi, Philippe Desprès, Pascale Krejbich-Trotot, wildriss viranaïcken

Subject: Biology And Life Sciences, Virology Keywords: Zika virus; unfolded protein response; ER stress; oligomer; disulfide bond amyloid aggregates

Online: 6 April 2022 (05:24:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0094.v1

Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection

Chung-Yang Yeh, Anthony Schulien, Bradley Molyneaux, Elias Aizenman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Ischemic Stroke; Reperfusion; Neuroprotection; Nerinetide; Kv2.1

Online: 4 August 2020 (11:28:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1751.v1

Antioxidant Activity of Planar Catechin Conjugated with Trolox

Wakana Shimizu, Yoshimi Shoji, Kei Ohkubo, Hiromu Ito, Ikuo Nakanishi, Kiyoshi Fukuhara

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: catechin; trolox; tocopherol; antioxidant activity

Online: 23 August 2024 (17:13:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0011.v1

Effect of Curcumin plus Piperine on Redox Imbalance and Inflammation in Inflammatory Bowel Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Amylly Sanuelly da Paz Martins, Orlando Roberto Pimentel de Araújo, Amanda da Silva Gomes, Fernanda Lívia Cavalcante Araujo, José Oliveira Junior, Joice Kelly Gomes de Vasconcelos, José Israel Rodrigues Junior, Islany Thaissa Cerqueira, Manoel Alvaro Lins Neto, Nassib Bezerra Bueno, Marília Oliveira Fonseca Goulart, Fabiana Andréa Moura

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Crohn's disease; Ulcerative colitis; Curcumin; Black pepper; Antioxidants

Online: 1 May 2024 (04:27:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0941.v1

Electrolyte Imbalance in Acute Traumatic Brain Injury: Insights from the First 24 Hours

Alina Săcărescu, Mihaela-Dana Turliuc

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: traumatic brain injury; electrolytes; early monitoring; Glasgow Coma Scale; chloride; potassium

Online: 13 August 2024 (14:39:41 CEST)

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Preprint ESSAY | doi:10.20944/preprints202009.0039.v1

Possibility of Tapping NADH Regenerated from Ethylene Glycol Utilization Pathway for Cofactor Regeneration

Wenfa Ng

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: NADH cofactor regeneration; ethylene glycol utilization; biocatalysis; atom economy; enzyme kinetics

Online: 2 September 2020 (09:56:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0506.v1

Redox Regulation of LAT Enhances T Cell-Mediated Inflammation

Jaime James, Ana Coelho, Gonzalo Fernandez Lahore, Clara Marquina Hernandez, Florian Forster, Bernard Malissen, Rikard Holmdahl

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: NCF1; Reactive Oxygen Species; Linker for Activation of T cells; T cell receptor signaling; Rheumatoid Arthritis

Online: 8 March 2024 (11:03:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0209.v1

A Single Buyer Model of Imbalance Cost Pass-Through Pricing Forecasting under Malaysia Electricity Supply Industry

Fatin Khairunnisa Khairuddin, Farah Anishah Zaini, Mohamad Fani Sulaima, Nur Hazahsha Shamsudin, Mohd Shahrin Abu Hanifah

Subject: Engineering, Electrical And Electronic Engineering Keywords: Electricity price; Incentive Based Regulation; Electricity Market; Forecasting; Time Series; Machine Learning

Online: 2 April 2024 (12:34:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0043.v1

The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction

Hilary Y. Liu, Jenna R. Gale, Ian J. Reynolds, John H. Weiss, Elias Aizenman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: zinc, mitochondria, neurodegeneration, calcium, energy metabolism, mitochondrial dynamics

Online: 2 March 2021 (09:03:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0458.v1

Age-Dependent Decline of NAD+ - Universal Truth or Confounded Consensus?

Augusto Peluso, Mads Vargas Damgaard, Marcelo Alves Mori, Jonas Thue Treebak

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: NAD+; aging; yeast; C. elegans; mouse; rat; monkey; human

Online: 24 November 2021 (13:10:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1499.v1

NAD Metabolism and Proteomic Profile in a Yeast Model Expressing a Neurotoxic polyQ Protein: Effect of Phenolics from Extra-virgin Olive Oil

Silvia Vincenzetti, Yusup Rozimemet, Sofia Renzi, Daniela Micozzi, Dennis Fiorini, Massimo Ricciutelli, Valeria Polzonetti, Stefania Pucciarelli

Subject: Biology And Life Sciences, Life Sciences Keywords: NAD; NMNAT; NaMN; yeast; ageing; polyQ prototoxicity; Huntingtin; Sirt2; EVOO; polyphenols.

Online: 26 February 2024 (19:52:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1672.v1

Comparison of Lupus and Lymphoma B-Cells Using Novel Immune Imbalance Transcriptomics Algorithm Reveals Potential Therapeutic Targets

Naomi Rapier-Sharman, Sehi Kim, Maddie Mudrow, Michael T. Told, Lane Fischer, Liesl Fawson, Joseph Parry, Brian D. Poole, Kim L. O’Neill, Stephen R. Piccolo, Brett E. Pickett

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: immune imbalance; Immune Imbalance Transcriptomics; IIT; B-cell lymphoma; Systemic Lupus Erythematosus (SLE); RNA-seq; algorithm; drug discovery; cancer; autoimmune disease

Online: 22 July 2024 (09:33:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1349.v1

Parkinson's Disease Recognition using Decorrelated Convolutional Neural Networks: Addressing Imbalance and Scanner Bias in rs-fMRI Data

Pranita Patil, W. Randolph Ford

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Class bias; DcCNN; decorrelation; deep learning; FE-DcCNN; invariant features; Parkinson’s disease; rs-fMRI image; scanner bias

Online: 22 March 2024 (09:21:12 CET)

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Parkinson’s Disease (PD) is a neurodegenerative and progressive disease that impacts the nerve cells in the brain and varies from person to person. The exact cause of PD is still unknown, and the diagnosis of PD does not include a specific objective test with certainty. Although deep learning has made great progress in medical neuroimaging analysis, these methods are very susceptible to biases present in neuroimaging datasets. An innovative decorrelated deep learning technique is introduced to mitigate class bias and scanner bias while simultaneously focusing on finding distinguishing characteristics in resting-state functional MRI (rs-fMRI) data, which assist in recognizing the PD with good accuracy. The decorrelation function reduces the non-linear correlation between features and bias in order to learn bias-invariant features. The Parkinson’s Progression Markers Initiative (PPMI) dataset, referred to as a single scanner imbalanced dataset in this study used to validate our method. The imbalanced dataset problem affects the performance of the deep learning framework by overfitting to the majority class. To resolve this problem, we propose a new Decorrelated Convolutional Neural Networks (DcCNN) framework by applying decorrelation-based optimization to Convolutional Neural Networks(CNN). An analysis of evaluation metrics comparisons shows that integrating the decorrelation function boosts the performance of PD recognition by removing class bias. Specifically, our DcCNN model performs significantly better than existing traditional approaches to tackle the imbalance problem. Finally, the same framework can be extended to create scanner invariant features without significantly impacting the performance of a model. The obtained dataset is a multi-scanner dataset which leads to scanner bias due to the differences in acquisition protocols and scanners. The multi-scanner dataset is a combination of two datasets, namely PPMI and FTLDNI - frontotemporal lobar degeneration neuroimaging initiative (NIFD) dataset. The results of t-distributed stochastic neighbor embedding (t-SNE) and scanner classification accuracy of our proposed Feature Extraction-DcCNN (FE-DcCNN) model validated the effective removal of scanner bias. Our method achieves an average accuracy of 77.80% on a multi-scanner dataset for differentiating PD from healthy control, which is superior to the DcCNN model trained on a single scanner imbalanced dataset.

Preprint COMMUNICATION | doi:10.20944/preprints202404.0526.v1

Data Is Power: Addressing the Power Imbalance Around Community Data with the Open-Access Data4HumanRights Curriculum

Monika Kuffer, Dana R. Thomson, Dianne Wakonyo, Nicera Wanjiru Kimani, Divyani Kohli, Enyo Okoko, Rasak Toheeb, Bisola Akinmuyiwa, Mohammed Zanna, Dezyno Imole, Andrew Maki

Subject: Social Sciences, Education Keywords: open-access training; deprivation; human rights; citizen science; LMICs; female leadership

Online: 8 April 2024 (09:56:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0684.v1

Inflammatory Prostatitis plus IBS-D Subtype and Correlation with the Immunomodulating Agent Imbalance in Seminal Plasma: Novel Combined Treatment

Roberto Castiglione, Gaetano Bertino, Beatrice Ornella Vicari, Agostino Rizzotto, Giuseppe Sidoti, Placido D'Agati, Michele Salemi, Giulia Malaguarnera, Enzo Vicari

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: irritable bowel syndrome; inflammatory prostatitis; IBS-severity scoring system; rifaximin; probiotic VSL#3; interleukins; seminal plasma

Online: 9 August 2024 (17:00:49 CEST)

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We recently demonstrated the effectiveness of long-term treatment with rifaximin and the probiotic VSL#3 at improving urogenital and gastrointestinal symptoms in patients with both chronic inflammatory prostatitis (IIIa prostatitis) and diarrhea-predominant irritable bowel syndrome (IBS-D), relative to patients with IBS-D alone. Because low-grade inflammation of the intestine and prostate may be one of the reasons for co-developing both IIIa prostatitis and IBS-D, we designed the present study to once again evaluate the efficacy of combined rifaximin and VSL#3 treatment in patients affected by IIIa prostatitis plus IBS-D, but we also measured seminal plasma pro-inflammatory (IL-6) and anti-inflammatory (IL-10) cytokines before and after treatment. We consecutively enrolled 124 patients with IIIa prostatitis and IBS-D (diagnosed using the Rome III criteria). Patients were randomized into two groups: group A (n=64) was treated with rifaximin (seven days per month for three months) followed by VSL#3, and group B (n=60) was treated with a placebo. At the beginning of the study and after three months of treatment, all patients completed NIH-CPSI and IBS-SSS questionnaires to score the severity of their urogenital and gastrointestinal symptoms, and we measured seminal plasma levels of IL-6 and IL-10 using ELISA. We defined patients who improved following the treatment as those with a ≥6-point reduction in their NIH-CPSI score or ≥50-point reduction in their IBS-SSS score. By the end of the intervention, 68.7% and 62.5% of patients from group A reported improved NIH-CPSI and IBS-SSS scores, respectively, compared to only 3.3% and 5% of the placebo group. Group A patients also had significantly lower mean seminal plasma levels of IL-6 (11.3 vs 32.4 pg/mL) and significantly higher mean levels of IL-10 (7.9 vs 4.4 pg/mL) relative to baseline, whereas levels of IL-6 and Il-10 did not change in the placebo group. The co-occurrence of two clinical phenotypes (IBS-D plus IIIa prostatitis) result in increased intestinal inflammation and altered immune activation, both of which can be balanced by treatment with rifaximin and VSL#3.

Preprint ARTICLE | doi:10.20944/preprints202405.0122.v2

Novel NH4V4O10-Reduced Graphene Oxide Cathodes for Zinc-Ion Batteries: Theoretical Predictions and Experimental Validation

He Lin, Chenfan Liu, Yu Zhang

Subject: Chemistry And Materials Science, Electrochemistry Keywords: zinc-ion batteries; cathode materials; NH4V4O10; reduced graphene oxide

Online: 24 June 2024 (13:52:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0320.v1

Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan

Arastu Sharma, Sophie Chabloz, Elisabeth M. Roider, Collin Y. Ewald

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; longevity; supplements; geroprotectors; SIRT1; NAD+; NMN; resveratrol; nutraceuticals; age-related diseases; flavonoids; senolytics; healthspan

Online: 17 November 2022 (02:51:11 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0392.v1

Hydrogen Peroxide and Redox Regulation of Development

Christine Rampon, Michel Volovitch, Alain Joliot, Sophie Vriz

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: H2O2, redox signalling, development, regeneration, adult stem cells, metazoan

Online: 19 September 2018 (21:42:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0029.v1

Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review.

Renate Viebahn-Haensler, Olga León Fernández

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: redox bioregulation; mitochondriopathies; low-dose ozone concept; ozone therapy; oxidative stress; antioxidant capacity

Online: 1 May 2024 (07:29:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0824.v1

Building Up a Human Ovarian Antioxidant ceRNA Network, OvAnOx: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and Dysfunctions

Carla Tatone, Giovanna Di Emidio, Rosalia Battaglia, Cinzia Di Pietro

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: ceRNA network; oxidative stress; female fertility; antioxidant cell defence; non-coding RNAs

Online: 12 August 2024 (14:02:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202003.0346.v1

The Molecular Story of COVID-19; NAD⁺Depletion Addresses All Questions in this Infection

Shirin Kouhpayeh, Laleh Shariati, Maryam Boshtam, Ilnaz Rahimmanesh, Mina Mirian, Mehrdad Zeinalian, Azhar Salari-jazi, Negar Khanahmad, Mohammad Sadegh Damavandi, Parisa Sadeghi, Hossein Khanahmad

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; nCoV 19; oxidative stress; PARP; PARG; TRPM2

Online: 23 March 2020 (07:40:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.0721.v1

Effort-Reward Imbalance and Passion Exploitation: A Narrative Review and a New Perspective

Keisuke Kokubun

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: effort-reward imbalance; passion exploitation; intrinsic motivation; transformational leadership

Online: 10 September 2024 (03:38:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0473.v1

An Overview of the Ferredoxin NAD+ Reductases Used for Energy Conservation in Various Anaerobic Microorganisms

Antoine Boullet, Isabelle Meynial-Salles

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Rnf complex; energy conservation; ferredoxin NAD+ reductase; anaerobic metabolism

Online: 25 July 2018 (09:39:35 CEST)

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In the context of the development of bioprocesses for the production of biofuels and bulk chemicals, microbial cells are rationally engineered to produce such molecules at high yield and titres in order to develop new biological methods that satisfy economic constraints. The redox and energetic balances of such strains play crucial roles in performance. Processes performed in strict anaerobes have a limited amount of energy available compared to that in aerobic organisms. This energy is obtained through fermentation and/or ion gradient-driven phosphorylation. Such anaerobic organisms have developed energy conservation mechanisms to increase ATP yields. This paper presents the properties of one of these mechanisms catalysed by the Rnf complex, an ion-translocating membrane complex with a ferredoxin NAD+ oxidoreductase activity. The Rnf complex performs the transfer of electrons from reduced ferredoxin to NAD+ coupled with an ion-motive transport. Ferredoxin is a common electron carrier for anaerobic bacteria and, with NAD+, is involved in several pathways of interest for the production of biofuels. This complex was first identified in Rhodobacter capsulatus and found to be involved in nitrogen fixation. It was then found to be involved in energy conservation in multiple anaerobic organisms, from acetobacteria such as Acetobacterium woodii to sulfate-reducing bacteria such as Desulfovibrio alaskensis and autotrophic bacteria such as Clostridium ljungdahlii and Clostridium aceticum. The Rnf complex triggers two types of ion transports: it can be either a sodium or a proton transporter. Both of these transports create a gradient of ions, generating a membrane potential that is then used by ATPase to produce ATP and thus serving as an energy conservation mechanism. In this review, the available information on the Rnf complex from genetic organization up to its in vivo and in vitro activities in several microorganisms is summarized, with a special focus on the proton-motive Rnf complex.

Preprint ARTICLE | doi:10.20944/preprints202408.0648.v1

Enhancing Polysulfide Redox Kinetics Through Synergistic Polarization of Ferroelectric (Ba0.9Sr0.1TiO3) Nanoparticles for High-Capacity Li-S Batteries.

Ivan Castillo, Balram Tripathi, Danilo Barrionuevo, Karuna K. Mishra, Gerardo Morell, Ram S. Katiyar

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: Li-S battery; C/S composite; BST coupling; polysulfide trapping; ferroelectric material

Online: 9 August 2024 (12:09:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1649.v2

Phylogenetic Analysis of Pyruvate-Ferredoxin Oxidoreductase, a Redox Enzyme Involved in the Activation of Nitro-Based Prodrugs in Bacteria and Protozoa

Seth Duwor, Daniela Brites, Pascal Mäser

Subject: Biology And Life Sciences, Life Sciences Keywords: Pyruvate-ferredoxin oxidoreductase; metronidazole; reductive bioactivation; antimicrobial spectrum; comparative genomics; horizontal gene transfer ;

Online: 1 March 2024 (07:57:55 CET)

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Simple Summary: The distribution of typical bacterial redox enzymes such as pyruvate-ferredoxin oxidoreductase (PFOR) in protozoa remains interestingly puzzling. Previous studies have demonstrated diverse cellular localizations of PFOR in some amitochondriate anaerobic protozoa. PFOR is of particular pharmacological importance because it catalyzes the reductive bio-activation of nitro-based prodrugs to cytotoxic radical metabolites. Metronidazole was developed primarily as an antiprotozoal agent against infections caused by Trichomonas vaginalis. However, its antimicrobial spectrum was subsequently expanded to cover anaerobic bacterial infections. It has been shown that mutations in the genes encoding PFOR result in inherent resistance of PFOR-possessing anaerobic protozoa and bacteria to nitro-based prodrugs. Deciphering the evolutionary history of PFOR is crucial in deepening our understanding of the evolution of anaerobic pathogens and unfold new approaches for drug discovery and targeting in pathogen chemotherapy. Abstract: The present frontrunners in the chemotherapy of infections caused by protozoa are nitro-based prodrugs that are selectively activated by PFOR-mediated redox reactions. This study seeks to analyze the distribution of PFOR in selected protozoa and bacteria by applying comparative bioinformatics approaches to test the hypothesis that PFOR was most likely acquired through horizontal gene transfer (HGT) from bacteria. Furthermore, to identify other genes that were putatively acquired using proteome-wide and gene expression analyses. A plausible explanation for the patchy occurrence of PFOR in protozoa is based on the hypothesis that bacteria are potential sources of genes that enhance optimal adaptation of protozoa in hostile environments. The exclusively expressed proteins obtained from Entamoeba histolytica and the putative gene donor, Desulfovibrio vulgaris, showed an over-expression of eleven genes involved in intermediary metabolism. If these results can be reproduced in other PFOR-possessing protozoa, it would provide a more validated evidence to support the horizontal transfer of pfor from bacteria.

Preprint ARTICLE | doi:10.20944/preprints202307.1684.v1

Redox Metabolism and Vascular Calcification in Chronic-Kidney Disease

Cristina Alonso-Montes, Natalia Carrillo-López, Sara Panizo, Beatriz Martín-Carro, Juan Carlos Mayo Barrallo, Pablo Román-García, Raúl García-Castro, Jesús M. Fernández-Gómez, Miguel A. Hevia-Suárez, Julia Martín-Vírgala, Sara Fernández-Villabrille, Laura Martínez-Arias, Sara Barrio Vázquez, Laura Calleros Basilio, Jorge Benito Cannata-Andía, Manuel Naves-Díaz, José Luis Fernández-Martín, Isabel Quirós-González

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Vascular calcification; Catalase; CKD; RUNX2; Epigastric arteries; DIGE

Online: 26 July 2023 (02:38:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0771.v1

Quantum Entanglement Asymmetry and the Cosmic Matter-Antimatter Imbalance: A Theoretical and Observational Analysis

Florian Neukart

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Quantum Entanglement Asymmetry; Matter-Antimatter Imbalance; Cosmic Microwave Background Anisotropies; Friedmann Equations; Cosmological Evolution

Online: 13 March 2024 (09:52:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0107.v1

Thioredoxins o1 and h2 Show Different Subcellular Localizations and Redox-Active Functions, but Cooperatively Affect NADPH Redox Poise and Photosynthetic Performance in Fluctuating Light

Liang-Yu Hou, Martin Lehmann, Peter Geigenberger

Subject: Biology And Life Sciences, Plant Sciences Keywords: Trx o1; Trx h2; metabolomics; ascorbate; glutathione; NAD(P)(H); photosynthetic performance; fluctuating light; Arabidopsis thaliana

Online: 2 March 2021 (16:19:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1840.v1

Resveratrol and Its Natural Analogs Mitigate Immune Dysregulation and Oxidative Imbalance in the Endometriosis Niche Simulated in a Co-Culture System of Endometriotic Cells and Macrophages

Agata Gołąbek-Grenda, Wojciech Juzwa, Mariusz Kaczmarek, Anna Olejnik

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: endometriosis; inflammation; macrophages; co-culture; transwell system; oxidative stress; resveratrol

Online: 27 August 2024 (03:18:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0180.v2

Redox Homeostasis and Nitro-Oxidative Stress in Obesity-Linked Inflammation

Guillaume Treiber, Hanen Samouda, Estelle Nobécourt, Serge P. Bottari

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: oxidative stress; nitrative stress; reactive oxygen species; reactive nitrogen species; nitric oxide inflammation; obesity; peroxynitrite; adipose tissue

Online: 30 September 2022 (11:10:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0024.v1

The Writers, Readers and Erasers in Redox Regulation of GAPDH

Maria Tossounian, Bruce Zhang, Ivan Gout

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: GAPDH; metabolism; moonlighting protein; redox regulation; oxidative PTMs; S-thiolation

Online: 1 December 2020 (13:14:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0019.v1

Techno-Economic Modeling and Analysis of Redox Flow Battery Systems

Jens Noack, Lars Wietschel, Nataliya Roznyatovskaya, Karsten Pinkwart, Jens Tübke

Subject: Engineering, Energy And Fuel Technology Keywords: redox flow battery; techno-economic analysis; materials; cost

Online: 2 August 2016 (11:41:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0737.v3

Monitoring the Redox Status in Multiple Sclerosis

Masaru Tanaka, László Vécsei

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: oxidative stress; redox; antioxidant; multiple sclerosis; biomarker; neurodegenerative disease; personalized medicine

Online: 22 September 2020 (08:42:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2255.v1

Assessment of Serum ACTH, Melatonin, and Cortisol Levels in Patients with Hormone Imbalance and Multiple Sclerosis

Muslim Mohammed Mosa jassim

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Multiple sclerosis; cortisol; ACTH; melatonin; inflammation; hypothalamic-pituitary-adrenal axis

Online: 30 August 2024 (15:45:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1238.v1

Plasma Redox Balance in Advanced Maternal Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

Elena Grossini, Carmen Imma Aquino, Sakthipriyan Venkatesan, Libera Troia, Eleonora Tizzoni, Federica Fumagalli, Daniela Ferrante, Rosanna Vaschetto, Valentino Remorgida, Daniela Surico

Subject: Medicine And Pharmacology, Reproductive Medicine Keywords: aging; antioxidants; lipid peroxidation; nitric oxide; pregnancy

Online: 20 March 2024 (16:56:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0221.v1

Chiral Perturbation Theory vs. Linear Sigma Model in A Chiral Imbalance Medium

Alexander Andrianov, Vladimir Andrianov, Domenec Espriu

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: chiral imbalance; Chiral Perturbation Theory; Linear Sigma Model; charged pion decay in chiral medium; local parity breaking

Online: 17 December 2019 (07:39:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0015.v1

Hybrid Incremental Model for Imbalance Detection in Ultra-high Precision Rotating Devices

Rodolfo Haber, Raúl Mario del Toro Matamoros

Subject: Engineering, Control And Systems Engineering Keywords: modeling; intelligent systems; imbalance detection; ultra-high precision rotating machine

Online: 3 October 2017 (13:39:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0390.v1

Redox Metabolism Measurement in Mammalian Cells and Tissues by LC-MS

Naama Kanarek, Boryana Petrova, Anna Warren, Nuria Yulia Vital, Adam G Maynard, Alan Wong

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: redox metabolites; mass-spectrometry method; HILIC chromatography; NADH; NADPH; Glutathione; redox metabolite detection in mammalian cells

Online: 14 April 2021 (16:09:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0525.v2

4-Hydroxynonenal in Redox Homeostasis of Gastrointestinal Mucosa: implications for Stomach in Health and Diseases

Andriy Cherkas, Neven Zarkovic

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: 4-Hydroxynonenal; lipid peroxidation; redox balance; oxidative stress; stomach; peptic ulcer; gastritis; Helicobacter pylori; gastric cancer; non-steroid anti-inflammatory drugs-induced gastropathy

Online: 23 August 2018 (04:24:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0003.v1

Human Milk Redox Homeostasis: The Gestational Pathologies Effect

Chiara Peila, Lorenzo Riboldi, Elena Spada, Alessandra Coscia, Ignazio Barbagallo, Giovanni Livolti, Fabio Galvano, Diego Gazzolo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Human milk; breastfeeding; GSH; LOOHs; preeclampsia; gestational diabetes mellitus; newborn nutrition

Online: 1 September 2023 (13:45:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0379.v1

Mass Transport Optimization for Redox Flow Battery Design

Nicholas Gurieff, Declan Finn Keogh, Mark Bladry, Victoria Timchenko, Donna Green, Ilpo Koskinen, Chris Menictas

Subject: Engineering, Energy And Fuel Technology Keywords: vanadium redox flow battery; power density; limiting current; cell geometry; mass transfer; electrolyte mixing; static mixer; industrial design; multidisciplinary research; energy transitions

Online: 26 March 2020 (01:51:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1290.v1

Convolutional Neural Network-Based ECG Signal Classification Model: A Study on Addressing Class Imbalance and Enhancing Model Interpretability

Guanjun Wang, Shuwen Zheng, Xuejun Yang, Yena Song, Zushen Tang, Yueyue Jiang, and Jiangtao Huo

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ECG signal classification; convolutional neural network; model interpretability; UMAP dimensionality reduction; SHAP value analysis

Online: 20 May 2024 (12:42:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0067.v1

The Effect of a Curved Non-Motorized treadmill on Running Gait Length, Imbalance and Step Angle

Andrew Hatchett, Kaitlyn Armstrong, Brian Parr, Mallory Crews, Charlie Tant

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: treadmill; curved; running gait; imbalance; step angle; stride length; step length

Online: 5 June 2018 (13:04:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0681.v1

An Enhanced Tree Ensemble for Classification in the Presence of Extreme Class Imbalance

Samir K. Safi, Sheema Gul

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Random Forest; Tree Selection; , Classification; Class-Imbalance Problem; Synthetic Data Generation

Online: 9 September 2024 (11:21:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1684.v1

A Regularized Tree Forest for Classification in the Presence of Extreme Class Imbalance

Samir K. Safi, Sheema Gul

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: ; machine learning; optimal tree ensemble classifier; random forest; support vector machine; artificial neural network ;

Online: 22 July 2024 (07:13:53 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0408.v1

Redox Regulation of PTEN by Bicarbonate and Hydrogen Peroxide: Implication of Peroxymonocarbonate

Vu Hoang Trinh, Jin Myung Choi, Thang Nguyen Huu, Dhiraj Kumar Sah, Hyun Joong Yoon, Sang Chul Park, Yu Seok Jung, Youngkeun Ahn, Seung-Rock Lee

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: PTEN; redox regulation; H2O2; bicarbonate; peroxymonocarbonate.; cell signaling

Online: 7 February 2024 (06:02:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0046.v1

Hydroxyhydroquinone and Quassinoids as Promising Compounds with Hypoglycemic Activity through Redox Balance

Paulo Roberto dos Santos, Sidineia Danetti, Joseph Rastegar, Wellington De Souza, Rafaele Frassini, Fernando Joel Scariot, Sidnei Moura, Mariana Roesch-Ely

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: hydroxyhydroquinone; quassinoids; glycemia

Online: 2 August 2023 (05:20:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1589.v1

Are Protein Cavities and Pockets Commonly Used by Redox Active Signalling Molecules?

John T. Hancock

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: argon; hydrogen peroxide; hydrogen sulfide; hydroxyl radicals; molecular hydrogen; nitric oxide; peroxynitrite; protein cavities; superoxide; xenon

Online: 23 May 2023 (07:12:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0344.v1

Redox Regulation and Oxidative Stress: The Particular Case of the Stallion Spermatozoa

Fernando Juan Peña Vega, Cristian O'Flaherty, Jose M. Ortiz Rodríguez, Francisco E. Martín Cano, Gemma L. Gaitskell-Phillips, María C. Gil, Cristina Ortega Ferrusola

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: horses; spermatozoa; ROS; oxidative stress; redox regulation; equine

Online: 30 September 2019 (08:06:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0171.v1

Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity, and Aging

Collin Y. Ewald

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: NOX, sulfenylation, Nrf2, SKN-1, centenarians, extracellular matrix, longevity

Online: 10 September 2018 (12:59:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0103.v1

Machine Learning Prediction of the Redox Activity of Quinones

Ilia Kichev, Lyuben Borislavov, Alia Tadjer, Radostina Stoyanova

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: quinones; machine learning; ridge regression; decision tree; ensemble methods; density functional theory; organic electrode materials

Online: 3 October 2023 (09:14:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0511.v1

Looking Back at the Early Times of Redox Biology

Leopold Flohe

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Ferroptosis; glutathione peroxidases; heme peroxidases; hydrogen peroxide; lipid peroxidation; nitrogen monoxide radical; superoxide dismutase; superoxide radical; thioredoxin

Online: 26 October 2020 (10:43:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1929.v1

The Structural Causes and Trend Evolution of Imbalance and Insufficiency of Development of Digital Inclusive Finance in China

Minghua Chen, Qinru Chu, Tengwen Zhang, Qian Li, Jianxu Liu, Woraphon Yamaka

Subject: Business, Economics And Management, Economics Keywords: digital inclusive finance; imbalance and insufficiency; weighted Dagum Gini coefficient; quantile standardization

Online: 26 May 2023 (11:11:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0322.v1

Effect of Physical Activity on Obesity in Second Stage Pupils of Elementary Schools in the Region of Ústí nad Labem

Jana Pyšná, Ladislav Pyšný, David Cihlář, Dominika Petrů, Martin Škopek

Subject: Business, Economics And Management, Accounting And Taxation Keywords: obesity; Body Mass Index; physical activity; education; pupils; health; lifestyle; sport

Online: 10 November 2020 (15:27:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1263.v1

Metabolic and Functional Interaction of H₂S and Sucrose in Maize Thermotolerance through Redox Homeodynamics

Xiao-Er Li, Hong-Dan Zhou, Zhong-Guang Li

Subject: Biology And Life Sciences, Plant Sciences Keywords: Hydrogen sulfide; maize seedlings; redox homeodynamics; sucrose signaling; thermotoleranceugh MG-scavenging system; Calcium; Maize seedling; Methylglyoxal; Methylglyoxal-scavenging system; Thermotolerance

Online: 20 May 2024 (09:51:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0203.v1

Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer

Adrian I Abdo, Zlatko Kopecki

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cold plasma; plasma-activated water; redox signalling; cancer; wound healing; Nrf2; MAPK; PI3K/Akt; endoplasmic reticulum stress

Online: 2 April 2024 (12:22:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0107.v1

On the Redox-Activity and Health-Effects of Atmospheric Primary and Secondary Aerosol: Phenomenology

Francesca Costabile, Stefano Decesari, Roberta Vecchi, Franco Lucarelli, Gabriele Curci, Dario Massabò, Matteo Rinaldi, Maurizio Gualtieri, Emanuela Corsini, Elena Menegola, Silvia Canepari, Lorenzo Massimi, Stefania Argentini, Maurizio Busetto, Gianluca Di Iulio, Luca Di Liberto, Marco Paglione, Igor Petenko, Mara Russo, Angela Marinoni, Gianpietro Casasanta, Sara Valentini, Vera Bernardoni, Federica Crova, Gianluigi Valli, Alice Corina Forello, Fabio Giardi, Silvia Nava, Giulia Pazzi, Paolo Prati, Virginia Vernocchi, Teresa La Torretta, Ettore Petralia, Milena Stracquadanio, Gabriele Zanini, Gloria Melzi, Emma Nozza, Martina Iulini, Donatella Caruso, Lucia Cioffi, Gabriele Imperato, Flavio Giavarini, Maria Battistoni, Francesca Di Renzo, Maria Agostina Frezzini, Cinzia Perrino, Maria Cristina Facchini

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: atmospheric aerosol; chemical composition; secondary aerosol; source apportionment; ultrafine particles; oxidative potential; exposure; toxicology; forecasting; micrometeorology

Online: 12 April 2022 (09:54:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0070.v1

Recent Advances in “pH and Redox Responsive Polymer-Nano- Composites for Cancer Therapy

Shivalingayya Gaddimath, Shivanand Payamalle, Keshavananda Prabhu CP, Jaehyun Hur

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: cancer; biological thiols; stimuli responsive; cancer therapeutics

Online: 4 December 2023 (02:26:05 CET)

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In recent years, cancer therapy has witnessed significant advancements, with a focus on personalized and targeted treatment strategies. One promising approach involves the use of stimuli-responsive biomaterials for site-specific drug release. Among these biomaterials, pH, and redox-triggered polymer-nano composites have gained immense attention due to their ability to respond to the specific tumor microenvironment, enhancing therapeutic efficacy while reducing off-target effects. Cancer cells often exhibit anomalous biochemical properties, attributed to lower cytosolic pH (acidic) and elevated redox potential through the epitomized upregulation of undesired genes. Such biological process substantially imbalance the level ions (protons) and biological thiols glutathione (GHS) in the cytoplasm as well as in the subcellular organelles. Superfluous accumulation of ions and redox imbalance is associated with proliferation, invasion, and growth of tumor. Because of high surface area, deep tissue penetration capability, higher hydrophilicity, hydrophobic interior for drug/gene efficient loading, biocompatibility and site-specific targeting efficiency, functionalized polymer nanocomposites are superior to conventional small molecular materials. Paradoxically conventional methods of drug delivery aided therapeutics accompanied with inherent drug/genes are encapsulated in biocompatible carrier or suitable transfecting agents generally suffered with low bioavailability, uncontrolled drug release, low cellular penetration, cellular internalization, toxicity, and poor drug loading efficiency. To overcome these issues, recently various multifunctional nanomaterials were developed, based on synergistic stimuli responsive aided drug release in a specified cellular or subcellular system. High therapeutic efficacy, of nanoparticles (NPs) mainly associated with surface functionalization through biocompatible polymeric materials, site-specific targeting units accompanied with stimuli responsive components. Followed by therapeutically important drug or genetic materials were loaded into NPs either in covalent or non-covalent approach. Intriguingly, combined pH and redox dual stimuli based functional materials specially based on polymeric nanocomposites for cancer therapeutics scarcely reported. This article provides the recent progress in pH and redox-responsive polymer-nano composites for site-specific drug delivery in cancer therapy. It explores design principles, fabrication methods, mechanism of action, and prospects of these dual-stimuli responsive biomaterials.

Preprint ARTICLE | doi:10.20944/preprints202308.0014.v2

Effects of Difluorophenyl Substituents on Structural, Redox, and Magnetic Properties of Blatter Radicals

Dmitry Gulyaev, Andrey Serykh, Evgeny Tretyakov, Anna Akyeva, Mikhail Syroeshkin, Dmitry Gorbunov, Svetlana Maltseva, Nina Gritsan, Galina Romanenko, Artem Bogomyakov

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Blatter radicals; fluorinated organic compounds; electrochemically reversible processes; antiferromagnetically coupled chains; magneto-structural correlations

Online: 2 August 2023 (05:04:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0914.v1

Yerba Maté (Ilex paraguariensis) Supplement Exerts Beneficial, Tissue-Specific Effects on Mitochondrial Efficiency and Redox Status in Healthy Adult Mice

Chase M. Walton, Erin R. Saito, Cali E. Warren, John G. Larsen, Nicole P. Remund, Paul R. Reynolds, Jason M. Hansen, And Benjamin T. Bikman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Yerba Maté; Metabolism; Obesity; Nutraceuticals; Mitochondria

Online: 14 September 2023 (03:32:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1006.v1

β-cyclodextrin Nanophotosensitizers for Redox-Sensitive Delivery of Chlorin e6

Jaewon Jo, Ji Yoon Kim, Je-Jung Yun, Young Ju Lee, Young-IL Jeong

Subject: Chemistry And Materials Science, Biomaterials Keywords: β-Cyclodextrin; redox-sensitive; cancer targeting; photodynamic therapy; chlorin e6

Online: 17 October 2023 (05:12:13 CEST)

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The aim of this study is to prepare redox-sensitive nanophotosensitizers for targeted delivery of chlorin e6 (Ce6) against cervical cancer. For this purpose, Ce6 was conjugated with β-cyclodextrin (bCD) via disulfide bond creating nanophotosensitizers that were fabricated for redox-sensitive delivery of Ce6 against cancer cells. bCD was treated with succinic anhydride to synthesize suc-cinylated bCD (bCDsu). After that, cystamine was attached to the carboxylic end of bCDsu (bCDsu-ss) and the amine end group of bCDsu-ss was conjugated with Ce6 (bCDsu-ss-Ce6). Chemical composition of bCDsu-ss-Ce6 was confirmed with 1H and 13C NMR spectra. bCDsu-ss-Ce6 nanophotosensitizers were fabricated by dialysis procedure. They formed small particles with an average particle size of 152.0±23.2 nm and they showed improved singlet oxygen (SO) generation in the aqueous solution under light irradiation and was significantly higher than that of Ce6 alone. Ce6 release rate from bCDsu-ss-Ce6 nanophotosensitizers was accelerated by addition of glutathione (GSH), indicating that bCDsu-ss-Ce6 nanophotosensitizers have re-dox-sensitive photosensitizer delivery capacity. bCDsu-ss-Ce6 nanophotosensitizers have low in-trinsic cytotoxicity against CCD986Sk human skin fibroblast cells as well as Ce6 alone. However, bCDsu-ss-Ce6 nanophotosensitizers showed improved Ce6 uptake ratio, higher reactive oxygen species (ROS) production and phototoxicity compared to those of Ce6 alone. GSH addition resulted in higher Ce6 uptake ratio, ROS generation and phototoxicity than those of Ce6 alone, indicating that bCDsu-ss-Ce6 nanophotosensitizers have redox-sensitive biological activity in vitro against HeLa human cervical cancer cells. At tumor xenograft model using HeLa cells, bCDsu-ss-Ce6 nanophotosensitizers efficiently accumulated in the tumor rather than normal organs, i.e. fluores-cence intensity in tumor tissues was significantly higher than those of other organs while Ce6 alone did not specifically target tumor tissue. These results indicated higher anticancer activity of bCDsu-ss-Ce6 nanophotosensitizers, by efficiently inhibiting growth of tumor in in vivo animal tumor xenograft study.

Preprint REVIEW | doi:10.20944/preprints202109.0449.v1

Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?

Lena Palaniyappan, Min Tae M. Park, Peter Jeon, Roberto Limongi, Kun Yang, Akira Sawa, Jean Théberge

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: glutathione; glutamate; psychosis; schizophrenia; redox; antioxidant; oxidative stress; myelin; spectroscopy

Online: 27 September 2021 (12:47:39 CEST)

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Working Paper ARTICLE

Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome

Jason M. Held

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cysteine oxidation redox systems biology proteomics signaling EGFR cryptic

Online: 10 April 2019 (10:07:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0222.v1

Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients

Ewa Ambrożewic, Piotr Wojcik, Adam Wronski, Wojciech Luczaj, Anna Jastrząb, Neven Zarkovic, Elżbieta Skrzydlewska

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: psoriasis, arthritis, inflammation, granulocytes, redox signaling, oxidative stress, lipid peroxidation, 4-hydroxynonenal, lipids, endocannabinoid system

Online: 12 September 2018 (13:43:16 CEST)

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Inflammatory granulocytes are characterized by oxidative burst, which may promote oxidative stress and lipid modification both in affected tissues and on systemic level. On the other hand, redox signaling involving lipid peroxidation products acting as second messengers of free radicals play important, not yet fully understood, roles in pathophysiology of inflammation and various stress-associated disorders. Therefore, the aim of this study was to evaluate the onset of oxidative stress and alterations of enzyme-dependent lipid metabolism resulting from redox imbalance in granulocytes and plasma obtained from patients with psoriasis vulgaris or psoriatic arthritis, in comparison to the healthy subjects. The results obtained revealed enhanced activity of pro-oxidant enzymes NADPH and xanthine oxidases in granulocytes, with a decrease of enzymatic and non-enzymatic antioxidants in plasma of psoriatic patients. The Nrf2 and its regulators were increased in both forms of psoriasis, while HO-1 levels were increased only in psoriasis vulgaris. Redox imbalance was associated with decreased levels of phospholipids and of free PUFAs, but with enhanced activity of enzymes involved in lipid metabolism (PLA2, PAF-AH COX1/2) and increased lipid peroxidation products 4-hydroxynonenal (4-HNE), isoprostanes and neuroprostanes. Increased endocannabinoids and GPR55 were observed in both forms of the disease, while expression of CB1 was increased only in pateints with psoriatic arthritis, opposite to CB2, which was increased only in psoriasis vulgaris. Protein modifications by ROS and lipid peroxidation product 4-HNE promoted apoptosis of granulocytes by increased caspases in both forms of psoriasis. This study indicates that excessive activation of granulocytes, causing oxidative stress and lipid modifications, is an important pathophysiology of psoriasis. Consequently, lower Nrf2 activity and CB2 expression may promote progression of psoriasis into advanced, arthritic form of the disease.

Preprint ARTICLE | doi:10.20944/preprints202112.0137.v1

Effect of 5-Azacitine Treatment on Redox Status and Inflammatory Condition in MDS Patients

Paola Montes, Ana Guerra-Librero, Paloma García, Mª Elena Cornejo-Calvo, Mª del Señor López, Tomás de Haro, Laura Martínez-Ruiz, Germaine Escames, Darío Acuña-Castroviejo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: myelodysplastic syndrome (MDS); oxidative stress; cytokines; inflammation; 5-Azacitidine; somatic alterations

Online: 8 December 2021 (14:36:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0229.v1

A Novel Hybrid Approach to the Diagnosis of Simultaneous Imbalance and Shaft-Bow in a Jeffcott Rotor-Bearing System.

Shyh-Chin Huang, Sherina Octaviani, Mohammad Najibullah

Subject: Engineering, Mechanical Engineering Keywords: hybrid approach; multi-fault diagnosis; machine learning; feed-forward neural network

Online: 5 March 2024 (06:36:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1062.v1

Is There Any Relationship between Scoliosis, Cervical Pain and Postural Imbalance in Parkinson’s Disease? A Cross-Sectional, Pilot Study

Gianpaolo Ronconi, Mariantonietta Ariani, Dario Mattia Gatto, Gioia Stefinlongo, Fabio Ingravalle, Daniele Coraci, Sefora Codazza, Maurizio Panunzio, Giorgio Ferriero, Paola Emilia Ferrara

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; scoliosis; postural imbalance; pain

Online: 14 December 2023 (07:20:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0776.v1

Redox Modulatory Potential of Methanol Extract of Pentaclethra Macrophylla Stem Bark

Petra Obioma Nnamani, Edith Obioma Diovu, Peter Ikechukwu, Akachukwu M Onwuka, Obiora Emmanuel Abonyi, Obinna Chibueze Ibezim, Birgitta Loretz, Mariia Nesterkina, Claus- Michael Lehr

Subject: Medicine And Pharmacology, Pharmacy Keywords: Pentaclethera macrophylla stem bark; Methanol extract; Bergenin; Acute toxicity; Antioxidant; DPPH.

Online: 12 July 2023 (08:56:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0031.v1

Direct Electron Transfer-type Bioelectrocatalysis of Redox Enzymes at Nanostructured Electrodes

Taiki Adachi, Yuki Kitazumi, Osamu Shirai, Kenji Kano

Subject: Chemistry And Materials Science, Electrochemistry Keywords: direct-electron transfer-type bioelectrocatalysis; nanostructures; mesoporous electrodes, curvature effect; protein engineering; bi-directional bioelectrocatalysis; hydrogenase; fructose dehydrogenase; bilirubin oxidase; formate dehydrogenase; ferredoxin-NADP+ reductase

Online: 3 February 2020 (13:34:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1398.v1

Sensory Properties, Redox Characteristics, and Impact on the Hemodynamics of the Flavanol-Rich Fraction Originated Grape and Blueberry

Naomi Osakabe, Toshihiko Shoji, Kurumi Onishi, Chie Hirahata, Kento Hiroki, Taiki Fushimi, Yasuyuki Fujii, Ursula Jacob, Ali Abdelhameed, Rosanna Di Paola, Salvatore Cuzzocrea, Vittorio Calabrese

Subject: Medicine And Pharmacology, Other Keywords: flavanol; astringency; O2･-; blood flow; sympathetic nerve

Online: 23 March 2024 (09:38:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.1016.v1

Nutraceuticals Modulating Mitophagy May Combat the Mitochondrial Dysfunction and Redox Stress in Several Cardiac Disorders

Moeka Nakashima, Naoko Suga, Satoru Matsuda

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: autophagy; mitophagy; AMPK; cardiomyocyte; cardiac arrhythmia; cardiovascular disease; cardiac failure

Online: 16 April 2024 (16:27:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1567.v1

Energy Imbalance Gap Was Associated with Body Mass Index and Sex in Latin American Adolescents—Results from the ELANS Study

Pablo Hernandez, Marianella Herrera-Cuenca, Gerson Ferrari, Rafaela Yépez Almeida, Martha Cecilia Yépez García, Mónica Villar Cáceres, Lilia Yadira Cortés Sanabria, Yaritza Sifontes, Maritza Landaeta-Jimenez, Georgina Gómez, Rafael Monge-Rojas, Rossina Pareja, Attilio Rigotti, Irina Kovalskys, Mauro Fisberg

Subject: Public Health And Healthcare, Other Keywords: energy balance; energy expenditure; energy intake; energy imbalance gap; underweight; overweight; Latin America

Online: 26 November 2023 (05:24:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0356.v1

Redox Regulation of PTEN by Reactive Oxygen Species: Role in Physiological Processes

Vu Hoang Trinh, Thang Huu Nguyen, Dhiraj Kumar Sah, Jin Myung Choi, Hyun Joong Yoon, Sang Chul Park, Yu Seok Jung, Seung-Rock Lee

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: PTEN; redox regulation; oxidative inhibition; ROS; cell signaling

Online: 5 January 2024 (02:00:24 CET)

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Preprint REVIEW | doi:10.20944/preprints201909.0244.v1

Cofactor F₄₂₀-Dependent Enzymes: An Under-Explored Resource for Asymmetric Redox Biocatalysis

Mihir V. Shah, James Antoney, Suk Woo Kang, Andrew C. Warden, Carol J. Hartley, Hadi Nazem-Bokaee, Colin J. Jackson, Colin Scott

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: cofactor F420; deazaflavin; oxidoreductase; hydride transfer; hydrogenation; asymmetric synthesis; cofactor biosynthesis

Online: 21 September 2019 (01:28:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1368.v2

Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature

Konstantin Vagin, Timur Gaynutdinov, Gulnaz Rakhmatullina, Rustam Nizamov, Marina Gallyamova, Konstantin Sychev, Vladimir Semenov

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: activator of the immune system; subpopulations of lymphocytes; polyglobulins; T-helpers (CD4); T-suppressors (CD8); radioprotector; hemoprotector; immunohemopoiesis

Online: 1 November 2023 (05:25:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0152.v1

Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Alzheimer’s disease; oxidative stress; presenilin; mitochondria; calcium; neuronal dysfunction; Nrf2

Online: 11 July 2022 (08:03:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0357.v1

Transcriptomics Reveals Granulosa Cell’s Coping through Redox, Inflammatory, Metabolic and Cytoskeleton Mechanisms under Acute Heat Stress

Abdul Sammad, Hanpeng Luo, Lirong Hu, Huabin Zhu, Yachun Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: granulosa cells; heat stress; apoptosis; oxidative stress; RNA-seq; transcriptomics; differentially expressed genes; signaling pathways

Online: 28 February 2022 (11:08:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2587.v1

Study of the Imbalance and Trading Settings on the Impact of the Intraday Electricity Trading on the Czech Transmission System Operation

Jakub Šrom, Igor Chemišinec, Zdenek Muller, Ghaeth Fandi

Subject: Engineering, Electrical And Electronic Engineering Keywords: transmission system; market; intraday market; electricity; capacity; imbalance; ancillary services

Online: 1 August 2024 (05:36:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0955.v1

Impact of Chlorella vulgaris Bioremediation and Selenium on Genotoxicity, Nephrotoxicity and Oxidative/Antioxidant Imbalance Induced by Polystyrene Nanoplastics in African Catfish (Clarias gariepinus)

Shimaa A. Abdelbaky, Zakaria M. Zaky, Doha Yahia, Mohamed H. Kotob, Mohammed A. Ali, Mohammed Aufy, Alaa El-Din H. Sayed

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Polystyrene nanoplastics; Oxidative stress; Single cell gel electrophoresis; Selenium; Chlorella vulgaris

Online: 12 January 2024 (10:41:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2069.v1

The Redox Homeostasis Alteration Is Restored by Melatonin Treatment in COVID-19 Patients

María Elena Soto, Israel Pérez-Torres, Linaloe Manzano-Pech, Adrían Palaciós-Chavarría, Rafael Ricardo Valdez-Vázquez, Verónica Guarner-Lans, Elizabeth Soria-Castro, Eulises Díaz-Díaz, Vicente Castrejón-Tellez

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Melatonin; SARS-CoV-2; oxidative stress; COVID-19; redox homeostasis; antioxidant enzymes

Online: 31 January 2024 (01:47:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0048.v1

In-Situ Flexibility of Both Redox-States of the Chloroplast Regulatory Protein CP12

Helene Launay, Hui Shao, Olivier Bornet, Francois-Xavier Cantrelle, Regine Lebrun, Veronique Receveur-Brechot, Brigitte Gontero

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Calvin-Benson-Bassham cycle; Conditionally disordered protein; Intrinsically disordered protein; photosynthesis regulation.

Online: 2 April 2021 (11:23:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1896.v1

The Rise of Proterozoic Diagenetic Spheroids Formed by Chemically Oscillating Reactions and Stimulated by Environmental Redox Changes

Princess Aira Buma-At, Dominic Papineau

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: concretion; botryoid; diagenesis; carbon cycle; fossilisation; Belousov-Zhabotinsky

Online: 27 August 2024 (11:10:31 CEST)

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Diagenetic spheroids are rounded mineralised structures in sedimentary rocks that span several orders of size dimensions. These objects include rosettes spanning tens of micrometres, millimetre-sized granules, and centimetre- to metre-scale botryoids, nodules and concretions. Connections between diagenetic spheroids and chemically oscillating reactions (COR) have been established based on chemical and pattern similarities. Nevertheless, it is unknown if there are variations in their occurrences throughout geological time, especially during periods of global environmental change. This is because COR are pattern-forming reactions where carboxylic acids are decarboxylated by strong oxidants like sulphuric acid, bromate, or iodate. The hypothesis is that there should be a greater number of diagenetic spheroids at periods of increased atmospheric-oceanic oxygenation levels. Hence, this work presents the first compilation of occurrences of diagenetic spheroids between 0.541 to 1.8 billion years ago (Ga). The compiled patterned objects are those with concentric laminations and radially aligned crystals, which are patterns akin to equidistant circularly concentric waves that radially propagate in COR. Another characteristic of diagenetic spheroids, such as in botryoidal minerals, is the destructive interfere that forms circular twins; this is identical to the COR pattern formed when circular waves meet. The timeline of Proterozoic diagenetic spheroids produced in this work reveals a significant increase of occurrences across the Ediacaran, which is attributed to increased environmental oxidation state. During this interval, seawater is known to have become richer in sulphate and iodate, which create ideal conditions for the abiotic and diagenetic oxidation of biomass. Therefore, increased occurrences of diagenetic spheroids in the Neoproterozoic possibly represents sedimentological evidence for abiotic decarboxylation reactions and widespread COR in productive environments. The distribution of diagenetic spheroids observed during the Proterozoic may also be more broadly applicable to other epochs of Earth history.

Preprint REVIEW | doi:10.20944/preprints202205.0294.v2

The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways. Crosstalk on Perioperative Antioxidant Therapy

Stelian Adrian Ritiu, Alexandru Florin Rogobete, Dorel Sandesc, Ovidiu Horea Bedreag, Marius Papurica, Sonia Elena Popovici, Daiana Toma, Robert Iulian Ivascu, Raluca Ramona Velovan, Dragos Nicolae Garofil, Dan Corneci, Melania Lavinia Bratu, Elena Mihaela Pahontu, Adriana Pistol

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: general anesthesia; redox; inflammation; antioxidants; hypermetabolism; microRNAs; biomarkers; oxidative stress; Vitamin C

Online: 6 June 2022 (05:09:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0365.v1

The Role of Natural Factors that Optimize Redox Status in Combating Type 2 Diabetes

Dawn S. Tuell, Evan A. Los, George A. Ford, William L. Stone

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: antioxidants; oxidative stress; reactive oxygen species; type 2 diabetes; pediatrics; redox; glycemic control; exercise; vitamin E; glutathione

Online: 19 January 2023 (15:10:23 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202005.0373.v1

COVID-19: Neutrophils “Unfriendly Fire” Imbalance Proteolytic Cascades Triggering Clinical Worsening and Viral Sepsis. Potential Role Explanation for Convalescent Plasma as “Fire Hose”

Pier Maria Fornasari

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: COVID-19; proteolytic cascades; thrombosis; viral sepsis

Online: 23 May 2020 (10:42:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2331.v1

Review of the Role of Mitochondria in the Actions of Nitroglycerin and Redox Disturbances Underlying Diseases It Treats

Wayne Kaesemeyer MD

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: nitroglycerin; glutathione; mitochondria; complex I; eNOS; nitric oxide; S-nitrosylation; S-glutathiolation; superoxide; acute heart failure; right heart failure; diuretic resistance; refractory angina; NLRP3 inflammasome

Online: 29 July 2024 (15:06:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1657.v1

Involvement of Liver Redox State in the Zi-Dovudine-Induced Hepatic Steatosis and Its Partial Prevention by Adenosine

Martha Lucinda Contreras-Zentella, Armando Butanda-Ochoa, Lourdes Sánchez-Sevilla, Rodolfo Díaz-Paredes, Rolando Hernández-Muñoz

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Liver redox state, Fatty liver, Hepatotoxicity, Insulin, Glucagon, Lactic acidosis, Cetosis

Online: 21 December 2023 (12:13:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1132.v1

Ozone as Redox Bioregulator in Preventive Medicine. The Molecular and Pharmacological Basis of the Low-Dose Ozone Concept

Renate Viebahn-Haensler, Olga Sonia León Fernández

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Covid-19; innate immune memory; rheumatoid arthritis; autoimmune disease; redox bioregulation

Online: 18 September 2023 (08:53:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1646.v1

Beneficial Effects of Limosilactobacillus Reuteri PBS072 and Bifidobacterium breve BB077 on Mood Imbalance, Self-Confidence, and Breastfeeding in Women during the First Trimester Post-partum

Franco Vicariotto, Patrizia Malfa, Michela Torricelli, Lisa Lungaro, Giacomo Caio, Vincenzo De Leo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: gut-brain axis; post-partum; depression; Limosilactobacillus reuteri PBS072; Bifidobacterium breve BB077; delivery; breastfeeding; probiotics

Online: 25 July 2023 (09:14:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2130.v1

Redox Chemistry of Pt(II) Complex with Non-Innocent NHC Bis(phenolate) Pincer Ligand: Electrochemical, Spectroscopic and Computational Aspects

Ilya K. Mikhailov, Zufar N. Gafurov, Alexey A. Kagilev, Vladimir I. Morozov, Artyom O. Kantyukov, Ekaterina Zueva, Gumar R. Ganeev, Ilyas F. Sakhapov, Asiya V. Toropchina, Igor A. Litvinov, Galina A. Gurina, Alexander A. Trifonov, Oleg G. Sinyashin, Dmitry G. Yakhvarov

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: cyclic voltammetry; electron paramagnetic resonance; DFT calculations; UV-VIS/NIR; phenoxyl radical; pincer complex; platinum complex; NHC ligand

Online: 1 August 2023 (03:38:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1414.v1

Culture of Bovine Aortic Endothelial Cells in Galactose Media Enhances Mitochondrial Plasticity and Changes Redox Sensing Altering Nrf2 and FOXO3 Levels

Leticia Selinger Galant, Laura Doblado, Rafael Radi, Andreza Fabro de Bem, Maria Monsalve

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: endothelial cell; glucose; galactose; mitochondria; antioxidants; oxidative metabolism; REDOX; FOXO3; NRF2

Online: 20 June 2024 (15:12:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1651.v1

Insulin Resistance Develops Due to an Imbalance in the Synthesis of Cyclic AMP and the Natural Cyclic AMP Antagonist Prostaglandyl-Inositol Cyclic Phosphate (Cyclic PIP)

Heinrich K Wasner

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: cyclic AMP; cyclic PIP; insulin resistance; prostaglandylinositol cyclic phosphate; protein phosphorylation; protein kinase A; protein ser/thr phosphatase; type 2 diabetes

Online: 25 September 2023 (11:05:29 CEST)

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Dear Ladies and Gentlemen, I thank you for suggesting to submit the manuscript with the title “Insulin resistance develops due to an imbalance in the synthesis of cyclic AMP and the natural cyclic AMP antagonist prostaglandylinositol cyclic phosphate (cyclic PIP)” to the Editorial Board of the MDPI journal Stresses, and I ask for consideration to publish it in the journal Stresses. It was previously submitted to the MDPI journal Int. J. Mol. Sci. (IJMS-195 6513), but it was found that 1) it would not fit within the scope of this special edition and 2) it would primarily deal with cyclic PIP and would have not enough literature citation on the topic insulin resistance. The present version of the manuscript is improved, but the content is the same. The goal of this review is not to write again a summary on nearly all reports on insulin resistance as this was done by Dr. Petersen and Dr. Shulman, whose review has 961 literature citations. The present manuscript compiles what is known on cyclic PIP in relation to insulin resistance and the reason of writing this manuscript was that the discovered facts on cyclic PIP synthesis allow to suggest how insulin resistance most likely starts. Hitherto, reports on insulin resistance did not come close to this question. I am convinced that the manuscript makes an essential contribution to the question what causes the development of insulin resistance, and I have to say that stress overload is one of the reasons. Unfortunately, I have to mention a topic, about which I do not like to talk. Years ago, research groups postulated with rigor that the mediator of insulin action would be a peptide and then they suggested various, extracellularly synthesized glycans as mediators. They caused confusions and a high degree of disbelief in the matter of mediators of insulin action. In my review on cyclic PIP in IUBMB Life from 2020, I wrote in the introduction that cyclic PIP should not be confused with these mediators. But I cannot write this in the introduction of every report. I am keeping fingers crossed so that the editor in charge will find fair and openminded reviewers. Last not least I confirm that neither the manuscript nor any part of its content is currently under consideration or published in another journal. Kind regards, Henrich Wasner, PhD, BioReg Biopharm, TiLab; University of Illinois at Chicago; 2242 West Harrison St., Ste. 201, Chicago, Il 60612; USA

Preprint ARTICLE | doi:10.20944/preprints202203.0201.v2

Insights Into the Mechanisms of Lactobacillus acidophilus Activity Against Entamoeba histolytica by Using Thiol-Redox-Proteomics

Lotem Sarid, Eva Zanditenas, Jun Ye, Meirav Trebicz-Geffen, Serge Ankri

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Entamoeba histolytica; Lactobacillus acidophilus; probiotic; redoxomics; cysteine proteases

Online: 12 April 2022 (10:22:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0341.v1

Getting the Right Grip? How Understanding Electrophile Selectivity Profiles Could Illuminate Our Understanding of Redox Signaling

Marcus J. C. Long, Lingxi Wang, Yimon Aye

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Covalent labeling; stereoselectivity; electrophile signaling; affinity; mechanism; kinetic control

Online: 30 September 2019 (07:53:42 CEST)

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Significance: Electrophile signaling is coming into focus as a bona fide cell signaling mechanism. The electrophilic regulation occurs typically through a sensing event (i.e., labeling of a protein) and a signaling event (the labeling event having an effect of the proteins activity, association, etc.). Recent advances: Herein, we focus on the first step of this process, electrophile sensing. Electrophile sensing is typically a deceptively simple reaction between the thiol of a protein-cysteine, of which there are around 200,000 in the human proteome, and a Michael acceptor, of which there are numerous flavors, including enals and enones. Recent data overall paint a picture that despite being a simple chemical reaction, electrophile sensing is a discerning process, showing labeling preferences that are often not in line with reactivity of the electrophile. Critical issues: With a view to trying to decide what brings about highly electrophile-reactive protein-cysteines, and how reactive these sensors may be, we discuss aspects of the thermodynamics and kinetics of covalent/non-covalent binding. Data made available by several laboratories indicate that it is likely that specific proteins exhibit highly stereo- and chemoselective electrophile sensing, which we take as good evidence for recognition between the electrophile and the protein prior to forming a covalent bond. Future directions: We propose experiments that could help us gain a better and more quantitative understanding of the mechanisms through which sensing comes about. We further extoll the importance of performing more detailed experiments on labeling and trying to standardize the way we assess protein-specific electrophile sensing.We propose experiments that could help us gain a better and more quantitative understanding of the mechanisms through which sensing comes about. We further extoll the importance of performing more detailed experiments on labeling and trying to standardize the way we assess protein-specific electrophile sensing.

Preprint ARTICLE | doi:10.20944/preprints201909.0087.v1

Electrochemical Synergies of Heterostructured Fe₂O₃-MnO Redox Couple for Oxygen Evolution Reaction in Alkaline Water Splitting

Junyeong Kim, Jun Neoung Heo, Jeong Yeon Do, Rama Krishna Chava, Misook Kang

Subject: Chemistry And Materials Science, Electrochemistry Keywords: heterostructured Fe2O3-MnO; oxygen evolution reaction; alkaline water splitting; electrochemical synergy

Online: 8 September 2019 (16:16:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0079.v1

NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity

Sanaz Dastghaib, Seyed Mohammad Shafiee, Fatemeh Ramezani, Niloufar Ashtari, Farhad Tabasi, Javad Saffari-Chaleshtori, Omid Vakili, Morvarid Siri, Somayeh Igder, Mojdeh Zamani, Mahshid Moballegh Nasery, Fariba Kokabi, Emilia Wiechec, Zohreh Mostafavi-Pour, Pooneh Mokarram, Saeid Ghavami

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: NF-E2-related factor 2; Drug resistance; Reactive oxygen species; Autophagy; Unfolded protein response

Online: 3 January 2024 (02:26:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0494.v1

Redox-Active Cerium Fluoride Nanoparticles Mitigate of Double-Stranded DNA Breakage and Modulate Gene Expression Due to Radiation Exposure In Vitro

Nikita N. Chukavin, Kristina O. Fillipova, Artem M. Ermakov, Ekaterina E. Karmanova, Nelli R. Popova, Viktoriia A. Anikina, Olga S. Ivanova, Vladimir K. Ivanov, Anton L. Popov

Subject: Biology And Life Sciences, Life Sciences Keywords: cerium fluoride nanoparticles; DNA reparation; double-strand brakes; X-ray radiation

Online: 7 December 2023 (16:53:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0949.v1

Preparation of Vanadium (3.5+) Electrolyte by Hydrothermal Reduction Process With Citric Acid for Vanadium Redox Flow Battery

Ung-Il Kang

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Vanadium sulfate (VOSO₄); Vanadium pentoxide (V₂O₅); Electrolyte; Citric acid; Hydrothermal reduction reaction (HRR); Vanadium redox flow battery (VRFB)

Online: 11 July 2024 (10:47:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0351.v1

Redox Homeostasis Disclosed in the Saltmarsh Plant Halimione portulacoides Upon a Short Waterborne Exposure to Inorganic Mercury

Patrícia Pereira, Joana Luísa Pereira, Ana Marques, Carlos Marques, Fátima Brandão, Rute Cesário, Silja Frankenbach, João Serôdio, Fernando J. M. Gonçalves, João Canário, Mário Pacheco

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Halimione portulacoides; inorganic mercury; bioaccumulation; antioxidant defenses; oxidative damage; photosynthetic activity

Online: 4 January 2024 (05:59:16 CET)

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