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Preprint ARTICLE | doi:10.20944/preprints201610.0051.v1

The Relationship between Residential Electricity Consumption and Income: A Piecewise Linear Model with Panel Data

Yanan Liu, Yixuan Gao, Yu Hao, Hua Liao

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: residential electricity consumption; income; piecewise linear model; China; robust tests

Online: 14 October 2016 (09:53:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0030.v2

Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China

Chao Wang, Shuang Li, Tao Li, Shanfa Yu, Junming Dai, Xiaoman Liu, Xiaojun Zhu, Yuqing Ji, Jin Wang

Subject: Social Sciences, Psychology Keywords: occupational stress; job burden-capital model; structural equation model; depression; well-being

Online: 4 August 2016 (12:47:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1249.v1

Long-Term Follow Up of Fecundability after Ectopic Pregnancy in Taiwan: A Nationwide Population-Based Study

Chih-Hsiang Yin, Yi-Liang Lee, Chia-Ching Chang, Wu-Chien Chien, Gwo-Jang Wu

Subject: Public Health And Healthcare, Primary Health Care Keywords: Ectopic pregnancy; pregnancy; pregnancy rate; fecundability

Online: 21 March 2024 (12:45:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0111.v1

Prognostic Significance of Serum Uric Acid and Exercise Capacity in Older Adults Hospitalized for Worsening Cardiovascular Disease

Akihiro Hirashiki MD, Atsuya Shimizu, Takahiro Kamimura, Manabu Kokubo, Kakeru Hashimoto, Ikue Ueda, Toyoaki Murohara

Subject: Physical Sciences, Other Keywords: uric acid; older adults; exercise capacity; prognosis

Online: 1 April 2024 (15:00:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0217.v1

Bacterial and Genetic Features of Raw Retail Pork Meat: Integrative Analysis of Antibiotic Susceptibility, Whole Genome Sequencing and Metagenomics

Michelle Lowe, Wilhelmina Strasheim, Wai Yin Chan, Olga Perovic

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: whole genome sequencing; metagenomics; antibiotic residue testing; retail pork meat; South Africa

Online: 2 July 2024 (14:50:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1356.v1

Impact of Southerly Surge on Rainfall Pattern Over Java, Bali, West Nusa Tenggara and East Nusa Tenggara during Asian Winter Monsoon and Its Relationship to MJO Condition

Trismidianto Trismidianto, Didi Satiadi, Wendi Harjupa, Ibnu Fathrio, Risyanto Risyanto, Elfira Saufina, Robi Muharsyah, Danang Eko Nuryanto, Fadli Nauval, Dita Fatria Andarini, Anis Purwaningsih, Teguh Harjana, Alfan Sukmana Praja, Adi Witono, Ina Juaeni, Bambang Suhandi

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Southerly Surge; MJO; Rainfall; Java Island; East Nusa Tenggara

Online: 19 June 2024 (14:10:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0104.v1

Icing Forecasting of High Voltage Transmission Line Using Weighted Least Square Support Vector Machine with Fireworks Algorithm for Feature Selection

Tiannan Ma, Dongxiao Niu

Subject: Computer Science And Mathematics, Computer Science Keywords: icing forecasting; fireworks algorithm; least square support vector machine; feature selection

Online: 27 September 2016 (11:16:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0197.v1

Genome-Wide Association Analysis Identifies Candidate Loci for the Callus Induction in Rice (Oryza sativa L.)

Wintai Kamolsukyeunyong, Yeetoh Dabbhadatta, Aornpilin Jaiprasert, Burin Thunnom, Wasin Poncheewin, Samart Wanchana, Vinitchan Ruanjaichon, Theerayut Toojinda, Parichart Burns

Subject: Biology And Life Sciences, Plant Sciences Keywords: Rice; GWAS; QTLs; callus induction; gene

Online: 2 July 2024 (11:10:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0827.v1

Assessing the Impact of Climate Change on Food Security in Northern Ghana: Causes and Coping Strategies in the Upper East Region

Gifty Akapule, Abdul-wahab Tahiru, Patrick Tandoh-offin, Helene Garti

Subject: Environmental And Earth Sciences, Environmental Science Keywords: climate change; food security; Ghana; consumption

Online: 10 September 2024 (15:12:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints201607.0041.v1

Focus on the development of natural gas hydrate in China

Zhongfu Tan, Ge Pan, Pingkuo Liu

Subject: Environmental And Earth Sciences, Environmental Science Keywords: natural gas hydrate; five forces model; intuitional arrangement

Online: 15 July 2016 (11:33:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0767.v1

Agricultural and Technology-Based Strategies to Improve Water Use Efficiency in Arid and Semiarid Areas

Saif F. Alharbi, Mohammed Aldakil, Abrar Felemban, Ahmed Abdelrahim

Subject: Environmental And Earth Sciences, Soil Science Keywords: Water use efficiency; Agricultural water use; crop production; Agronomic practices

Online: 13 May 2024 (08:12:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0247.v1

Process Analysis and Modelling of Operators Performance in Classical and Digitalized Assembly Workstations

Georgiana Cătălina NEACŞU (DOBRIŞAN), Eduard Laurenţiu NIŢU, Ana Cornelia GAVRILUŢĂ, Georgica Gheorghiţa VLAD, Elena Mădălina DOBRE, Marian GHEORGHE, Maria Magdalena STAN

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: lean learning factory; assembly workstations; DOJO; industry 4.0; regression analysis

Online: 5 February 2024 (13:34:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.1355.v1

A Comprehensive Review of Electric Vehicles Fast Charging Developments and Technology

Ahmed Taher Zentani, Ali M. A. Almaktoof, MTE Kahn

Subject: Engineering, Electrical And Electronic Engineering Keywords: Electrical vehicles; DC fast charging; power electronics converters; control strategies

Online: 19 April 2024 (16:03:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0280.v1

Low- and Highly Pathogenic Avian Influenza a Viruses in Seal Population: A Brief Overview of 45-Years History

Klaudia Chrzastek, Darrell R Kapczynski

Subject: Biology And Life Sciences, Virology Keywords: avian influenza virus; marine mammals; seals; LPAIV; HPAIV; H5N1

Online: 5 September 2024 (06:57:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0690.v1

Strategic Intelligence: A Semantic Leadership Perspective

Dan Paiuc, Adina Săniuță, Alina Mirela Teacu Parincu

Subject: Business, Economics And Management, Business And Management Keywords: strategic intelligence; leadership; neuroleadership; global management; cultural intelligence; knowledge dynamics.

Online: 10 April 2024 (12:04:01 CEST)

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Strategic intelligence covers the examination of what impacts and influences the business and the related SWOT analysis, (strengths, weaknesses, opportunities, and threats mapping). Through this research, leaders will be able to properly allocate and re-route resources, identify areas of improvement, and ensure that strategic initiatives are aligned with the organization's mission. Strategic intelligence is, therefore, effective through the use of critical thought and data-driven decisions and seeing the outcomes of different positioned alternatives. It must also form and support a culture of cooperation and open communication within the organizations, stimulating employees' inputs and learning curves. The article's subject is the necessity for strategic intelligence, a crucial competence for leaders, managers, and companies striving to remain competitive, to be utilized and best leveraged in today's volatile and dynamic business contexts. It helps the leadership turn proactive, foresee trends, and make correct, agile decisions that enforce companies' long-term growth and success. This study follows a research design that includes a thorough literature review and bibliometric research, executed via VoSViewer, illustrating the concept of strategic intelligence from a leadership point of view as a driver of competitive advantage. Further, the article points out that the limitations are acknowledged because the literature on the matter is limited, as strategic intelligence is relatively new to the business sector; moreover, more research is required to fully understand and use the potential of strategic intelligence in business growth. By overcoming these limitations and continuing to study this concept, businesses can gain a competitive edge and make informed decisions that fuel their success in an ever-evolving market. As a result, this study contributes to developing strategic intelligence in leadership and business and paves the road for further research and applications of strategic intelligence theories in organizational contexts.

Preprint ARTICLE | doi:10.20944/preprints202405.0728.v1

Application of Multiplex Genome Editing Technology on Targeted Improvement of Ecological Adaptability of the Geng Rice Variety Jiahe212

Dengmei He, Xi Chen, Ran Zhou, Chenbo Huang, Yanhui Li, Zequn Peng, Dian Li, Wenjing Duan, Liyong Cao, Shihua Cheng, Xiaodeng Zhan, Lianping Sun, Shiqiang Wang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Rice; Flowering period; Multiplex Genome Editing; Breed improvement

Online: 12 May 2024 (07:44:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1631.v1

Prescribed Fire Reduces Wildfire Damages to Valued Resources Within the Okefenokee National Wildlife Refuge

C. Wade Ross, E. Louise Loudermilk, Joseph J. O’Brien, Steven A. Flanagan, Grant Snitker, J. Kevin Hiers

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: burn severity; controlled burn; dNBR; fuels treatments; GAM; LANDFIRE; prescribed fire; valued resources; wildfire; wildland fire

Online: 22 July 2024 (05:02:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2506.v1

Metabolic function and Therapeutic Potential of CD147 for Hematological Malignancies: An Overview

Isabella Spinello, Catherine Labbaye, Ernestina Saulle

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Hematological Malignancies; Metabolism; CD147

Online: 31 July 2024 (11:07:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0871.v1

Enhanced Multi-Scale Attention-Driven 3D Human Reconstruction from Single Image

Yong Ren, Mingquan Zhou, Pengbo Zhou, Shibo Wang, Yangyang Liu, Guohua Geng, Kang Li, Xin Cao

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: enhancing multi-scale attention; single image; normal map; human reconstruction

Online: 11 September 2024 (10:34:23 CEST)

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Due to the inherent limitations of a single viewpoint, reconstructing 3D human meshes 1 from a single image has long been a challenging task. While deep learning networks enable us to 2 approximate the shape of unseen sides, capturing the texture details of the non-visible side remains 3 difficult with just one image. Traditional methods utilize Generative Adversarial Networks (GANs) 4 to predict the normal maps of the non-visible side, thereby inferring detailed textures and wrinkles 5 on the model’s surface. However, we have identified challenges with existing normal prediction 6 networks when dealing with complex scenes, such as a lack of focus on local features and insufficient 7 modeling of spatial relationships.To address these challenges, we introduce EMAR—Enhanced 8 Multi-scale Attention-driven Single Image 3D Human Reconstruction. This approach incorporates 9 a novel Enhanced Multi-Scale Attention (EMSA) mechanism, which excels at capturing intricate 10 features and global relationships in complex scenes. EMSA surpasses traditional single-scale attention 11 mechanisms by adaptively adjusting the weights between features, enabling the network to more 12 effectively leverage information across various scales.Furthermore, we have improved the feature 13 fusion method to better integrate representations from different scales. This enhanced feature fusion 14 allows the network to more comprehensively understand both fine details and global structures 15 within the image. Finally, we have designed a hybrid loss function tailored to the introduced attention 16 mechanism and feature fusion method, optimizing the network’s training process and enhancing the 17 quality of reconstruction results.Our network demonstrates significant improvements in performance 18 for 3D human model reconstruction. Experimental results show that our method exhibits greater 19 robustness to challenging poses compared to traditional single-scale approaches.

Preprint ARTICLE | doi:10.20944/preprints201702.0089.v2

Analysis of Barriers to Wide Spread Adoption of Electric Vehicles in Shenzhen China

Faping Wang, Jiali Yu, Peng Yang, Lixin Miao, Bin Ye

Subject: Engineering, Transportation Science And Technology Keywords: EVs; PHEVs; penetration; adoption; barriers; preference; willingness; attitude

Online: 26 February 2017 (10:33:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1204.v1

Quality of Service and Associated Communication Infrastructure for Electric Vehicles

Rajeshkumar RAMRAJ, Ehsan PASHAJAVID, Sanath ALAHAKOON, Shantha JAYASINGHE

Subject: Engineering, Electrical And Electronic Engineering Keywords: electric vehicle; grid energy; quality of service; EV communication; energy management; planning and operation

Online: 19 September 2023 (05:35:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0173.v1

Cell Recruitment and the Origin of Anterior-Posterior Asymmetry in the Drosophila Wing

Rosalio Reyes, Rafael Rodriguez-Muñoz, Marcos Nahmad

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Drosophila wing; Anterior-Posterior; cell recruitment; asymmetry; morphometrics

Online: 2 April 2024 (16:19:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0642.v1

Fused Filament Fabrication of WC-10Co Hardmetals: A Study on Binder Formulations, and printing variables.

Julián David Rubiano Buitrago, Andrés Fernando Gil Plazas, Luis Alejandro Boyacá Mendivelso, Liz Karen Herrera Quintero

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: Hardmetals; Fused Filament Fabrication; Additive Manufacturing; Feedstock Formulation; Printing Force Measurement.

Online: 10 May 2024 (12:14:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1326.v1

Development of an Italian National Epidemiological Register on Endometriosis based on Administrative Data

Alice Maraschini, Emiliano Ceccarelli, Manuela Giangreco, Lorenzo Monasta, Valerio Manno, Dolores Catelan, Giorgia Stoppa, Annibale Biggeri, Giuseppe Ricci, Francesca Buonomo, Giada Minelli, Luca Ronfani

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Endometriosis; epidemiology; incidence; prevalence; population-based

Online: 22 April 2024 (08:48:29 CEST)

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Background: Endometriosis is a female chronic inflammatory disease in which endometrial tissue develops outside the uterine cavity. It is a complex pathology, that significantly contributes to morbidity in premenopausal women, leading to chronic pain, infertility, and subfertility negatively impacting the physical, and emotional well-being and overall quality of life. The public health burden of endometriosis remains elusive and challenging to determine, and this uncertainty can lead to inadequate healthcare services and treatments. Objective: To estimate the incidence and prevalence of endometriosis in Italy using the hospital discharge records database. Population-based retrospective study. Nationwide between 2011 and 2020. Methods: From the National Hospital Discharge Database were selected all admissions with a diagnosis of endometriosis (ICD-9-CM, codes 617.x), supported by the presence of a procedure code of laparoscopy or any other surgical procedure allowing direct visualisation of the lesions. Main outcomes measures Incidence and prevalence of endometriosis were estimated for the entire 2010-2020 period and by individual year, analysing the time trend and variability in different geographical areas of Italy. Results: A total of 134,667,646 women aged 15–50 years with one or more hospitalisations for endometriosis in all Italian hospitals. The incidence of endometriosis in Italy during this period was 0.839 per 1000 women (CI95% 0.834-0.844), exhibiting a statistically significant decreasing trend over the years. A discernible north-south gradient was observed, with higher rates documented in the northern regions. The prevalence rate stood at 14.0 per 1000 during the same period, and a similar north-south geographical gradient was identifiable in the prevalence rates as well. Conclusions: The utilization of national-level hospital data enables the generation of incidence and prevalence data for endometriosis without variations in methods and definitions, facilitating the evaluation of temporal trends and regional comparisons. Understanding and quantifying this phenomenon is essential for appropriate healthcare planning in various Italian regions.

Preprint REVIEW | doi:10.20944/preprints202402.1513.v1

Agricultural Disaster Prevention System: A Review of the Strategies in Taiwan

Ming-Hwi Yao, Yung-Heng Hsu, Ting-Yi Li, Yung-Ming Chen

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: weather forecast; early warning system; disaster prevention; crop; information and communication technology (ICT)

Online: 27 February 2024 (10:29:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1169.v1

Puzzling Regulation of Interferon Signaling System by p53 Tumor Suppressor Protein

Agnieszka Będzińska, Barbara Łasut-Szyszka, Małgorzata Krześniak, Agnieszka Gdowicz-Kłosok, Marek Rusin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: p53; interferon; STAT1; NK-92; caspase-1; innate immunity

Online: 17 April 2024 (14:47:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1916.v1

Retrospective Longitudinal Observational Study on The Long-Term Effects of Sodium-Glucose Cotransporter-2 Inhibitors on The Development of Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetic Japanese Patients

Hisayuki Katsuyama, Seiichi Horinaka, Mariko Hakoshima, Hiroki Adachi, Hidekatsu Yanai

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: cardiovascular disease; hepatic fibrosis; metabolic dysfunction-associated steatotic liver disease; sodium-glucose cotransporter 2 inhibitors; serum lipids

Online: 24 July 2024 (08:27:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0356.v1

Learning-Based Non-Intrusive Electric Load Monitoring for Smart Energy Management

Nian He, Dengfeng Liu, Zhichen Zhang, Zhiquan Lin, Tiesong Zhao, Yiwen Xu

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Smart City; Smart Electric Energy Management; Electric Load Monitoring; Load Recognition Algorithm; Computer Vision

Online: 4 April 2024 (08:13:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1804.v1

A New Chinese Named Entity Recognition Method for Pig Disease Domain Based on Lexicon Enhanced BERT and Contrastive Learning

Cheng Peng, Xiajun Wang, Qifeng Li, Qinyang Yu, Ruixiang Jiang, Weihong Ma, Wenbiao Wu, Rui Meng, Haiyan Li, Heju Huai, Shuyan Wang, Longjuan He

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: pig disease; Chinese named entity recognition; lexicon enhanced BERT; contrastive learning; small sample

Online: 23 July 2024 (16:05:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0668.v3

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development

Inamul Haque, Pritam Thapa, Douglas M Burns, Jianping Zhou, Mukut Sharma, Ram Sharma, Vikas Singh

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: epilepsy; neuroinflammation; NLRP3 inflammasome; epileptogenesis; antiseizure medication; interleukin-1b; caspase-1; ASC

Online: 31 May 2024 (15:29:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1518.v1

A Significance of Endothelial Dysfunction in Long COVID-19 for The Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama, Akahito Sako

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atherosclerotic cardiovascular disease; chronic kidney disease; endothelial dysfunction; long coronavirus disease 19.

Online: 21 June 2024 (11:45:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0914.v1

Horndeski-Like Gravity Perturbation Induced by Large-Magnitude Earthquake

Elias Koorambas

Subject: Physical Sciences, Theoretical Physics Keywords: Alternative theories of gravity; Gravitational waves; Sound waves; Earthquakes

Online: 14 May 2024 (06:50:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1483.v1

Review of Hybrid Energy Storage Systems for Hybrid Electric Vehicles

Ahtisham Urooj, Ali Nasir

Subject: Engineering, Electrical And Electronic Engineering Keywords: Hybrid Energy Storage system; Hybrid Electric Vehicle; HESS with Battery and Ultra capacitor; HESS flywheel; Energy management strategy

Online: 23 May 2024 (07:35:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0629.v1

Chemometric Analysis of GC-MS Chemical Profiles and Biological Activities of Three Citrus Essential Oils in Indonesia

Einstivina Nuryandani, Erliana Novitasari, Muhammad Fatih Abdurrahman, Nurul Habibi, Ardiba Rakhmi Sefrienda, Dedy Kurnianto, Jasmadi Jasmadi, Yusuf Andriana

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Citrus species, particle component analysis, essential oils, antioxidant activity, cytotoxicity effects, chemometric analysis

Online: 10 May 2024 (09:11:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2329.v1

Subclinical Left Ventricular Dysfunction over Seven-year Follow-up in Type 2 Diabetes Patients without Cardiovascular Diseases

Dariga Uaydinichna Akasheva, Tatyana Gennadyevna Utina, Olga Nikolaevna Dzhioeva, Oxana Mikhailovna Drapkina

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: type 2 diabetes; subclinical left ventricular dysfunction; diastolic disfunction; global longitudinal strain

Online: 30 July 2024 (07:04:33 CEST)

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Objective: Subclinical left ventricular disfunction (LVD) is common in asymptomatic patients with type 2 diabetes (T2D). Many patients with diabetes have an impaired diastolic and systolic function. With preserved ejection fraction LV (EFLV), the latter is defined as reduced global longitudinal strain (GLS), detected using the speckle-tracking echocardiography. This study is aimed to define the long-term structural and functional disorders of the LV myocardium in patients with T2D without CVD. Methods: Of the 120 patients with and without T2D of both sexes aged from 45 to 75 years (57.11±7.9 years), included in the study in 2012-2013, only 57 responded to the follow-up study. The patients were divided into two groups: one with T2D (n=29), the other without it, control (n=28). All patients underwent transthoracic two-dimensional echocardiography with assessment of standard indicators of systolic and diastolic cardiac function, as well as GLS. In addition, all participants underwent laboratory diagnostics of carbohydrate metabolism disorders markers, NT-proBNP and CRP. The median follow-up duration was 7.2 [7.0-7.8] years. Results: During the follow-up, a statistically significant increase in the incidence of diastolic dysfunction (DD) in the type 2 diabetes group was found from 53% to 61% (p = 0.004); no significant dynamics were noted in the control group (p = 0.48). The presence of T2D significantly increases the risk of developing DD (p=0.04). The presence of T2D, increased fasting glucose levels, and an increased HOMA index were independent predictors of the development of DD. Impairment of LVEF was not observed in both groups. At the same time, the proportion of patients with reduced GLS (< -18%) increased in the T2D group (p = 0.036). A significant difference in the frequency of decreased GLS depending on T2D was demonstrated. The presence of obesity, an increase in the HOMA index and an increase in CRP levels are independent predictors of impaired GLS. Conclusions: T2D is an independent risk factor for the worsening of subclinical left ventricular dysfunction in asymptomatic patients with T2D without CVD over 7-year follow-up. Diastolic dysfunction is represented by delayed relaxation of the LV myocardium; with preserved LVEF, reduced 2D GLS identifies systolic dysfunction. The tight control of glycemia, lipidemia, blood pressure and body weight is associated with the absence of poor clinical outcomes.

Preprint ARTICLE | doi:10.20944/preprints202408.2140.v1

Single−molecule Level Quantification Reveals the Interaction between Melittin and Lipopolysaccharide by Atomic Force Microscopy

Sheng Huang, Guoqi Su, Li Yang, Liangguang Yue, Li Chen, Jinxiu Huang, Feiyun Yang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: melittin; lipopolysaccharide; atomic force microscopy; interaction force; kinetics characteristics

Online: 30 August 2024 (03:37:03 CEST)

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The interaction forces and mechanical properties of the interaction between melittin (Mel) and lipopolysaccharide (LPS) are considered a crucial driving force for Mel in killing Gram−negative bacteria (GNB). However, how their interaction forces are performed at the single−molecule level and the dissociation kinetic characteristics of the Mel/LPS complex remain poorly understood. In this study, the single−molecule level interaction forces between Mel and LPSs from E. coil K−12, O55:B5, O111:B4, and O128:B12 were explored using atomic force microscopy (AFM) based single−molecule force spectroscopy (SMFS). Further, the AFM−based dynamic force spectroscopy (DFS) and advanced analytical model were employed to investigate the kinetic characteristics of the Mel/LPSs complex dissociation. The results indicated that Mel could interact with both rough (R)−form LPS (E. coli K−12) and smooth (S)−form LPSs (E. coli O55:B5, O111:B4, O128:B12), and the S−form LPSs showed a more robust interaction with Mel than R−form LPS, and a slight difference existed in the interaction forces between Mel and diverse S−form LPSs. The Mel interacts with S−form LPSs showed greater specific and non−specific interaction forces than R−form LPS (p < 0.05), as determined by AFM−based SMFS. However, there was no significant difference in the specific and non−specific interaction forces among the three S−form LPSs (p > 0.05), indicating the variability of O−antigen could not affect the interaction between Mel and LPSs. The DFS result showed that the Mel/S−form LPSs complexes had a lower dissociation rate constant (koff), a shorter energy barrier width (xβ), a longer bond lifetime (τoff), and a higher height of the energy barrier (∆G), demonstrating that Mel could interact with S−form LPSs to form more stable complexes. In conclusion, this study promotes our knowledge of the interaction micromechanics and kinetics characteristics between Mel and LPS at the single−molecule level. Moreover, it can help us design and evaluate new anti−GNB drugs.

Preprint COMMUNICATION | doi:10.20944/preprints202402.1610.v1

Exceptional Lithography Sensitivity Boosted by Hexafluoroisopropanols in Photoresists

Junjun Liu, Dong Wang, Yitan Li, Haihua Wang, Huan Chen, Qianqian Wang, Wenbing Kang

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Hexafluoroisopropanol; high-sensitivity; photoresist; photoacid generation

Online: 28 February 2024 (08:04:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1018.v1

Management of Short Bowel Syndrome/Chronic Intestinal Failure – the Experience of a Single Portuguese Center

Marisa Domingues Santos, Vânia Magalhães, Luís Loureiro, Pedro Pina, Ana Castro, Paulina Aguiar, Ana Gomes, Diana Soares, Anabela Rocha

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Keywords; Short bowel Syndrome; Chronic Intestinal failure; Home Parenteral Nutrition; Teduglutide; Complications of Parenteral Support

Online: 19 February 2024 (16:24:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1794.v1

Genomic Characterization of Carbapenemase-Producing Enterobacter hormaechei, Serratia marcescens, Citrobacter freundii, Providencia stuartii and Morganella morganii Clinical Isolates from Bulgaria

Stefana Sabtcheva, Ivan Stoikov, Ivan N. Ivanov, Deyan Donchev, Magdalena Lesseva, Sylvia Georgieva, Deana Teneva, Elina Dobreva, Iva Christova

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: carbapenemases; NDM-1; VIM-4; VIM-86; OXA-48; horizontal gene transfer; Enterobacter; Serratia; Citrobacter; Providencia; Morganella

Online: 28 April 2024 (08:17:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0391.v1

24-Step Short-term Power Load Forecasting Model Utilizing KOA-BiTCN-BiGRU-Attentions

Mingshen Xu, Wanli Liu, Shijie Wang, Jingjia Tian, Peng Wu, Congjiu Xie

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: dual carbon target; load forecasting; KOA; BiTCN-BiGRU-Attention

Online: 4 July 2024 (11:18:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2054.v1

Named Entity Recognition Based on Contrastive Learning and Enhanced Lexicon for Pig Diseases of Chinese Corpus

Cheng Peng, Xiajun Wang, Qifeng Li, Qinyang Yu, Ruixiang Jiang, Weihong Ma, Wenbiao Wu, Rui Meng, Haiyan Li, Heju Huai, Shuyan Wang, Longjuan He

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Chinese Named Entity Recognition; Pig disease; Lexicon enhanced; Contrastive learning

Online: 30 May 2024 (13:41:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1373.v1

COVID-19 Vaccine Hesitancy among Health Providers at Kenyatta National Teaching and Referral Hospital Nairobi-Kenya

Phelix Okello, Vallery Ogello, Nicholas Thuo, Gakuo Maina, Paul Mwangi, Peter Mogere, Paul Mutua, Harrison Mwenda, Linnet Ongeri, John Kinuthia, Nelly Mugo, Kenneth Ngure

Subject: Social Sciences, Behavior Sciences Keywords: COVID-19 Vaccine; Hesitancy; Healthcare Providers; Kenya

Online: 17 July 2024 (08:13:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1588.v1

Cephalometric Evaluation of Children with Short Stature of Genetic Etiology. A Review

George Paltoglou, Nickolas Ziakas, George P. Chrousos, Christos Yapijakis

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: short stature; genetics; genetic syndromes; craniofacial morphology; cephalometric radiograph; growth hormone/insulin-like growth factor 1 axis; epiphyseal growth plate; cartilage extracellular matrix

Online: 24 May 2024 (11:17:53 CEST)

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Introduction: A plethora of biological molecules regulate chondrogenesis in the epiphyseal growth plate. Disruptions of quantity and function of these molecules can manifest clinically as stature abnormalities of various etiologies. Traditionally, the growth hormone/insulin-like growth factor 1 (IGF1) axis represents the etiological center of final stature attainment. Of note, little is known about the molecular events that dominate the growth of the craniofacial complex and its correlation with somatic stature. Aim: Given the paucity of the relevant data, this review discusses available information regarding potential applications of lateral cephalometric radiography as a potential clinical indicator of genetic short stature in children. Materials and Methods: A literature search was conducted in the PubMed electronic database using the key words: cephalometric analysis and short stature; cephalometric analysis and achondroplasia; cephalometric analysis and hypochondroplasia; cephalometric analysis and skeletal abnormalities; cephalometr* and SHOX; cephalometr* and CNP; cephalometr* and ACAN; cephalometr* and CNVs; cephalometr* and IHH; cephalometr* and FGFR3; cephalometr* and Noonan syndrome; cephalometr* and “Turner syndrome”; cephalometr* and achondroplasia. Results: In individuals with genetic syndromes causing short stature, linear growth of the craniofacial complex is confined, following the pattern of somatic short stature regardless of its etiology. The angular cephalometric measurements differ from the average height normal individuals and are suggestive of a posterior placement of the jaws and a vertical growth pattern of the face. Conclusion: The greater part of the existing literature regarding cephalometric measurements in short statured children with genetic syndromes provides qualitative data. Furthermore, cephalometric data for individuals affected with specific rare genetic conditions causing short stature, should be the focus of future studies. These quantitative data are required to potentially establish cut-off values to refer for genetic testing based on craniofacial phenotypes.

Preprint ARTICLE | doi:10.20944/preprints202408.0015.v1

Detection of Dengue Virus 1 and Mammalian Orthoreovirus 3, with Novel Reassortments, in a South African Family Returning from Thailand, 2017

Petrus Jansen van Vuren, Rhys H. Parry, Janusz T. Paweska

Subject: Biology And Life Sciences, Virology Keywords: dengue virus; mammalian orthoreovirus; MRV; imported infections; clinical metagenomics; metagenomics

Online: 1 August 2024 (11:13:04 CEST)

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In July 2017, a family of three members; a 46-year-old male, a 45-year-old female and their 8-year-old daughter, returned to South Africa from Thailand. They presented symptoms consistent with mosquito-borne diseases, including fever, headaches, severe body aches and nausea. Mosquito bites in all family members suggested recent exposure to arthropod-borne viruses. Dengue virus 1 (Genus Orthoflavivirus) was isolated (isolate no. SA397) from the serum of the 45-year-old female via intracerebral injection in neonatal mice and subsequent passage in VeroE6 cells. Phylogenetic analysis of this strain indicated close genetic identity with cosmopolitan genotype 1 DENV1 strains from Southeast Asia, assigned to major lineage K, minor lineage 1 (DENV1I_K.1), such as GZ8H (99.92%) collected in November 2018 from China and DV1I-TM19-74 isolate (99.72%) identified in Bangkok, Thailand, in 2019. Serum samples from the 46-year-old male yielded a virus isolate that could not be confirmed as DENV1, prompting unbiased metagenomic sequencing for virus identification and characterization. Illumina sequencing identified multiple segments of a Mammalian orthoreovirus (MRV), designated Human/SA395/SA/2017. Genomic and phylogenetic analysis classified Human/SA395/SA/2017 as MRV-3 and assigned a tentative genotype MRV-3d based on the S1 segment. Genomic analyses suggested Human/SA395/SA/2017 may have originated from reassortments of segments among swine, bat, and human MRVs. The closest identity of the viral attachment protein σ1 (S1) was related to a human isolate identified from Tahiti, French Polynesia, in 1960. This indicates ongoing circulation and cocirculation of Southeast Asian and Polynesian strains, but detailed knowledge is hampered by limited availability of genomic surveillance. This case represents a rare concurrent importation of two distinct viruses with different transmission routes in the same family with similar clinical presentations. It highlights the complexities of diagnosing diseases with similar sequelae in travellers returning from tropical areas.

Preprint ARTICLE | doi:10.20944/preprints202409.0722.v1

Benchmarking of DNA Extraction Methods for Metagenomics, 16S rRNA Databases and Assessment of the Skimmed Milk Flocculation for Bacterial Enrichment for Metagenomics from Water Samples

Deyan Donchev, Ivan Stoikov, Antonia Diukendjieva, Ivan N. Ivanov

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: skimmed milk flocculation; vacuum filtration; bacterial metagenomics; benchmarking; DNA extraction; water samples; taxonomic composition; MIQ score; mock standard

Online: 10 September 2024 (10:08:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0823.v1

The Impact of Breast Cancer Risk Factors: Socio-Economic, Hormonal, and Clinical Insights from Hassan II Regional Oncology Center, Morocco

Mouas Fatima Ezahra, Doudach Latifa, Addoum Boutaina, Attaleb Mohammed, Mohammed El Mzibri, Benbacer Laïla, Rais Ghizlane, Fechtali Taoufiq

Subject: Medicine And Pharmacology, Other Keywords: Breast cancer; socio-economic; factors; hormonal; clinical; treatments; stategies

Online: 11 September 2024 (00:14:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0571.v1

Tracing the EoL-Tyre Management Chain in Togo with Focus of Implementing a Tyre Recycling Plant

Mona-Maria Narra, Djangbadjoa Gbiete, Komi Agboka, Satyanarayana Narra, Michael Nelles

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: End-of-Life tyres; Recycling; Togo; tyres

Online: 6 September 2024 (16:06:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0053.v1

A Novel Anti-Lock Braking System for Electric Vehicles

Chia-Hung Tu, Chun-Liang Lin, Meng-Yao Yang, En-Ping Chen

Subject: Engineering, Automotive Engineering Keywords: electrical vehicle; anti-lock braking system (ABS); regenerative brake; control

Online: 5 August 2016 (09:49:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0338.v1

Impact of Gut Microbiota and SCFAs in PCOS Pathogenesis and Metformin on Therapy

Evgenii Kukaev, Ekaterina Kirillova, Alisa Tokareva, Elena Rimskaya, Natalia Starodubtseva, Galina Chernukha, Tatiana Priputnevich, Vladimir Frankevich, Gennady Sukhikh

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: metabolomics; polycystic ovary syndrome; short-chain fatty acids; pathogenesis; intestinal microbiota; gas chromatography–mass spectrometry

Online: 4 September 2024 (08:42:49 CEST)

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Polycystic ovary syndrome (PCOS) is a complex disorder that impacts both the endocrine and metabolic systems. The gut microbiota plays a crucial role in in metabolism regulation and immune responses through its interaction with the external environment. This article explores the intricate interplay between intestinal flora and the pathogenesis of PCOS, focusing on the pivotal role of microbial metabolites, specifically short-chain fatty acids (SCFAs). SCFA levels in fecal and blood samples from women with PCOS (n=69) and healthy controls (n=18) were analyzed using Gas Chromatography-Mass Spectrometry (GC/MS) for precise measurement. The results revealed that women with PCOS exhibited a significant reduction in beneficial bacteria alongside a notable overgrowth of opportunistic microorganisms. An overproduction of acetic acid (AA) and valeric acid (VA) in fecal samples suggests a link between elevated SCFAs and the development of obesity and PCOS. Interestingly, AA in the bloodstream might offer a protective effect against PCOS by ameliorating key symptoms such as high body mass index (BMI), insulin resistance (IR), and chronic inflammation. This finding points to the potential therapeutic value of maintaining optimal AA levels in the blood. Although serum SCFA levels showed non-significant changes following metformin treatment, the normalization of AA in the gut underscores that metformin exerts a more pronounced effect locally within the gastrointestinal tract. This treatment also led to an increase in beneficial gut bacteria and a reduction in opportunistic pathogens, suggesting a restoration of gut microbial balance. Furthermore, the study identified the most effective model for predicting the success of metformin therapy, based on serum concentrations of butyric acid (BA) and VA, achieving a 91% accuracy rate, 100% sensitivity, and 80% specificity. These promising findings highlight the potential for developing targeted interventions and personalized treatments, ultimately improving clinical outcomes for women with PCOS.

Preprint ARTICLE | doi:10.20944/preprints201702.0107.v1

Maximum Storm Tide Response to the Intensity of Typhoons and Bathymetric Changes along the East Coast of Taiwan

Wen-Cheng Liu, Wei-Bo Chen, Lee-Yaw Lin

Subject: Engineering, Control And Systems Engineering Keywords: maximum storm tide; two-dimensional tide-surge modeling system; east coast of Taiwan; intensity of typhoon; bathymetric rise

Online: 28 February 2017 (13:00:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1802.v1

First-Trimester Preeclampsia-Induced Disturbance in Maternal Blood Serum Proteome: A Pilot Study

Natalia Starodubtseva, Alisa Tokareva, Alexey Kononikhin, Alexander Brzhozovskiy, Anna Bugrova, Evgenii Kukaev, Kamilla Muminova, Alina Nakhabina, Vladimir E. Frankevich, Evgeny Nikolaev, Gennady Sukhikh

Subject: Biology And Life Sciences, Life Sciences Keywords: preeclampsia; prognosis; quantitative proteomics; screening; mass spectrometry; serum; pregnancy

Online: 27 August 2024 (04:34:32 CEST)

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Preeclampsia (PE) is a complex and multifaceted obstetric syndrome characterized by several distinct molecular subtypes. It complicates up to 5% of pregnancies and significantly contributes to maternal and newborn morbidity, thereby diminishing the long-term quality of life for affected women. Due to the widespread dissatisfaction with the effectiveness of existing approaches for assessing PE risk, there is a pressing need for ongoing research to identify newer, more accurate predictors. This study aimed to investigate early changes in the maternal serum proteome and associated signaling pathways. The levels of 125 maternal serum proteins at 11-13 weeks of gestation were quantified using liquid chromatography-multiple reaction monitoring mass spectrometry (LC-MRM MS) with the BAK-125 kit. Ten serum proteins emerged as potential early markers for PE: Apolipoprotein M (APOM), Complement C1q subcomponent subunit B (C1QB), Lysozyme (LYZ), Prothrombin (F2), Albumin (ALB), Zinc-alpha-2-glycoprotein (AZGP1), Tenascin-X (TNXB), Alpha-1-antitrypsin (SERPINA1), Attractin (ATRN), and Apolipoprotein A-IV (APOA4). Notably, nine of these proteins have previously been associated with PE in prior research, underscoring the consistency and reliability of our findings. These proteins play key roles in critical molecular processes, including complement and coagulation cascades, platelet activation, and insulin-like growth factor pathways. To improve the early prediction of PE, a highly effective Support Vector Machine (SVM) model was developed, analyzing 19 maternal serum proteins from the first trimester. This model achieved an Area Under the Curve (AUC) of 0.91, with 87% sensitivity and 95% specificity, and a hazard ratio (HR) of 13.5 (4.6 - 40.8) with p<0.001. These findings demonstrate that serum protein-based SVM models possess significantly higher predictive power compared to the routine first-trimester screening test, highlighting their superior utility in the early detection and risk stratification of PE.

Preprint ARTICLE | doi:10.20944/preprints202406.1767.v1

Associations of Serum Levels of cGAMP in the Context of COVID-19 Infection, Atherosclerosis, Sterile Inflammation, and Functional Endothelial Biomarkers in Patients With Coronary Heart Disease and Healthy Volunteers

Nadezhda G. Gumanova, Natalya L Bogdanova, Yaroslav I. Havrichenko, Alexander U. Gorshkov

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; serum biomarkers; sterile inflammation; serum cGAMP; serum nitrite and nitrate (NOx); endothelin-1; endothelial dysfunction; SCORE; atherosclerosis

Online: 26 June 2024 (12:29:59 CEST)

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Abstract: Background: COVID-19 is associated with various changes in immunity, including signaling through the pattern-recognition receptors (PRR). However, the role of these processes is poorly understood. The present study aimed to evaluate the relationships of the serum levels of the cyclic dinucleotide 2’3’-cyclic GMP-AMP (cGAMP) marker of PRR activation with immunoglobulin G antibodies against severe acute respiratory syndrome-linked coronavirus (IgG-SARS)-positive status and endothelial dysfunction in apparently healthy subjects and in patients with coronary heart disease (CHD). Methods: The present study investigated selected groups from two cohorts, including cohort 1 of 307 healthy volunteers and cohort 2 of 218 CHD patients. COVID-19 infection was confirmed by the detection of IgG-SARS against SARS-CoV-2 S1 protein receptor-binding domain. Cohort 1 (24–69 years of age; 44.8 ± 8.6 years; 80.4% men) was examined for systematic coronary risk evaluation by European Society of Cardiology (SCORE) starting from 2019 before the onset of the COVID-19 pandemic. Cohort 2 (63±10.9 years of age, 54% men) was processed starting from 2017 (three years prior to the COVID-19 pandemic) in a hospital setting to undergo coronary angiography to assess coronary lesions as Gensini score. The levels of cGAMP and endothelial markers (nitrate and nitrite combined as NOx and endothelin-1) were assessed in the serum to evaluate the associations with IgG-SARS status, SCORE, and extent of coronary lesions by correlation and receiver operating characteristic (ROC) analyses. Results: Serum cGAMP did not discriminate between SARS-positive and SARS-negative healthy subject of cohort 1. Moreover, the level of cGAMP was not associated with endothelial biomarkers in healthy subjects. However, serum cGAMP was associated with atherosclerosis in cohort 2 in patients with CHD (area under the curve (AUC) 0.69; 95% CI 0.587-0.806; P=0.001), indicating that serum cGAMP was lower in patients with coronary stenosis compared to that in patients without coronary lesions. Conclusions: Low levels of serum cGAMP were associated with atherosclerosis and markers of endothelial dysfunction in patients with CHD. However, cGAMP was not associated with endothelial biomarkers or IgG-SASR immune status in healthy subjects, suggesting that cGAMP may be a new biomarker of coronary lesions in the context of sterile inflammation.

Preprint ARTICLE | doi:10.20944/preprints202405.0033.v1

Raw Material Purchasing Optimization Using Column Generation

Zhen Gao, Danning Li, Danni Wang, Zengcai Yu

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Purchasing; optimization; MILP; column generation

Online: 1 May 2024 (16:46:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0975.v1

Machine Learning Approaches for Stroke Risk Prediction: Findings from the Suita Study

Thien Vu, Yoshihiro Kokubo, Mai Inoue, Masaki Yamamoto, Attayeb Mohsen, Agustin Martin-Morales, Takao Inoué, Research Dawadi, Michihiro Araki

Subject: Public Health And Healthcare, Other Keywords: Stroke; supervised machine learning; unsupervised machine learning; Logistic Regression; Random Forest; Support Vector Machine (SVM); eXtreme Gradient Boost (XGBoost); Light Gradient Boosted Machine (Light-GBM); K-prototype clustering; Shapley Addictive ExPlanations (SHAP)

Online: 14 May 2024 (13:25:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0120.v1

On the Impact of Geospace Weather on the Occurrence of M7.8 /M7.5 Earthquakes of 02.06.2023 (Turkey), Possibly Associated with the Geomagnetic Storm of 11.07.2022

Dimitar Ouzounov, Galina Khachikyan

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: solar wind; geomagnetic storm onset; polar cusp; geospace weather; magnetic local time; earthquake

Online: 2 May 2024 (09:57:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1547.v1

Time Series Forecasting with Missing Values Using Multiple Models: An Application to Wind Energy Systems

Xiaoou Li

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: time series forecasting; ARIMA; neural networks; transfer learning; wind energy systems

Online: 28 February 2024 (11:27:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2088.v1

The Case of Clean Customer Master Data for Customer Analytics: A Neglected Element for Data Monetization

Jasmin Singh, Heiko Gebauer

Subject: Business, Economics And Management, Business And Management Keywords: Customer analytics; data cleanliness; data harmonization; data integration; data monetization; digitization; digitalization; digital transformation; and; customer master data

Online: 25 July 2024 (16:53:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1572.v1

Dietary Regulation of Lipid Metabolism in Gestational Diabetes Mellitus: Implications for Fetal Macrosomia

Natalya Frankevich, Vitaliy Chagovets, Alisa Tokareva, Natalia Starodubtseva, Elizaveta Limonova, Gennady Sukhikh, Vladimir Frankevich

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: macrosomia; gestational diabetes mellitus; obesity; lipidome; mass-spectrometry; diet therapy

Online: 20 September 2024 (04:46:16 CEST)

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The primary therapeutic method for correcting hyperglycemia today is diet therapy. Lipids are not only a source of nutrients but can also act as initiators of adipocyte differentiation in the fetus, which explains the development of fetal macrosomia and future metabolic disorders in children born to mothers with gestational diabetes mellitus (GDM). Changes in the profile of circulating lipids in the maternal bloodstream, depending on adherence to a rational diet among mothers with GDM and the development of fetal macrosomia, is a complex and not fully understood process. The aim of the study was to examine the characteristics of the lipid profile in the blood plasma of pregnant women with GDM in all trimesters of pregnancy based on adherence to diet therapy. The design of the clinical part of the work was carried out within the framework of a 'case-control' study.The study included 110 women, 80 of whom were in the control group, 20 in the group with GDM adhering to the diet, and 10 in the group with GDM not adhering to the diet. The laboratory part was conducted as part of a longitudinal dynamic study with venous blood samples taken at three points: 11-13, 24-26, and 30-32 weeks of pregnancy.A significant impact of diet therapy on the blood lipid composition throughout pregnancy was demonstrated, starting as early as the first trimester. ROC analysis showed high effectiveness of the developed models with an AUC of 0.98 for the "30-32 weeks" model, with sensitivity and specificity of 1 and 0.9, respectively. An association was found between diet, maternal blood lipid composition at 32 weeks of pregnancy, and newborn weight. The direction of changes in the lipid spectrum during the development of macrosomia and diet therapy is diametrically opposed. This confirms at the molecular level that diet therapy can normalize not only carbohydrate but also lipid metabolism in the mother and fetus. Based on the obtained data, it can be suggested that after validation, the developed models could be used to refine the prognosis of macrosomia development based on the lipid profile of blood plasma at different stages of pregnancy.

Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1653.v2

The p53 tumor suppressor protein activates transcription of DUSP13 isoform from the alternative promoter in intron

Małgorzata Krześniak, Barbara Łasut-Szyszka, Agnieszka Będzińska, Agnieszka Gdowicz-Kłosok, Marek Rusin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: p53; MDM2; DUSP13; alternative promoter; dual-specificity phosphatase

Online: 26 February 2024 (16:55:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0099.v1

CO₂ Gasification Reactivity of Chars Derived From Zhundong Coal

Yun Liu, Yanjun Guan, Kai Zhang

Subject: Engineering, Control And Systems Engineering Keywords: Zhundong coal; char; CO2 gasification; alkali and alkaline earth metals

Online: 23 January 2017 (09:27:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1410.v1

Study Protocol for a Prospective Self-Controlled Trial on Success in Meeting Comprehensive Genomic Profiling Analysis Criteria for Specimens Obtained by Endoscopic Ultrasound-Guided Tissue Acquisition Using a 19G Needle from Primary and Metastatic Lesions

Kotaro Takeshita, Susumu Hijioka, Yoshikuni Nagashio, Hidenobu Hara, Daiki Agarie, Yuki Kawasaki, Tetsuro Takasaki, Shin Yagi, Yuya Hagiwara, Kohei Okamoto, Daiki Yamashige, Soma Fukuda, Masaru Kuwada, Yasuhiro Komori, Mao Okada, Yuta Maruki, Chigusa Morizane, Hideki Ueno, Yasushi Yatabe, Takuji Okusaka

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: endoscopic ultrasound-guided tissue acquisition; comprehensive genomic profiling; pancreatic cancer; metastatic lesion; fine-needle biopsy

Online: 20 June 2024 (13:14:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1046.v1

Brazilian Borreliosis: An In-depth Review of Incidence, Diagnostic Challenges, and Awareness Efforts in Brazil

Mônica E.T. Alcon-Chino, Salvatore Giovanni De-Simone

Subject: Biology And Life Sciences, Parasitology Keywords: Lyme disease; neuroborreliosis; diagnose; immunological diagnosis

Online: 16 April 2024 (10:48:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0703.v1

Safety and Immunogenicity of the Intranasal Vaccine Candidate Mambisa and the Intramuscular Vaccine Abdala Used as Booster Doses for COVID-19 Convalescents: A Randomized Phase 1–2 Clinical Trial

Gilda Lemos-Pérez, Yinet Barrese-Pérez, Yahima Chacón-Quintero, Rolando Uranga-Piña, Yisel Avila-Albuerne, Iglermis Figueroa-García, Osaida Calderín-Marín, Martha M. Gómez-Vázquez, Marjoris Piñera-Martínez, Sheila Chávez-Valdés, Ricardo Martínez-Rosales, Lismary Ávila-Díaz, Amalia Vázquez-Arteaga, Hany González-Formental, Giselle Freyre-Corrales, Edelgis Coizeau-Rodríguez, Miladys Limonta-Fernández, Marta Ayala-Avila, Eduardo Martínez-Díaz, Eulogio Pimentel-Vazquez, Gerardo Enrique Guillén-Nieto

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS-CoV-2; COVID-19 vaccines; convalescents; booster; intranasal; intramuscular; vaccination; Cuba

Online: 11 June 2024 (12:00:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0716.v1

An Approach to Evaluate Healthcare Service Quality by Incorporating Linguistic Assessment and Computing

Wen-Pai Wang, Mei-Ling Huang, Yen-Chuan Ou

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Healthcare service quality; 2-tuple representation; heterogeneity; fuzzy linguistic computing; group multi-criteria decision-making

Online: 10 April 2024 (09:57:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0600.v1

Characterization of Avian Influenza Viruses Detected in Kenyan Live Bird Markets and Wild Bird Habitats Reveal Genetically Diverse Subtypes and High Proportion of A(H9N2), 2018-2020

Peninah Munyua, Eric Osoro, Joyce Jones, George Njogu, Genyan Yang, Elizabeth Hunsperger, Christine Szablewski, Ruth Njoroge, Doris Marwanga, Harry Oyas, Ben Andagalu, Romona Ndanyi, Nancy Otieno, Vincent Obanda, Carolyne Nasimiyu, Obadiah Njagi, Juliana DaSilva, Yunho Jang, John R Barnes, Gideon Emukule, Clayton Onyango, Charles Davis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Africa; surveillance; poultry diseases; avian influenza; low pathogenic

Online: 8 August 2024 (08:53:37 CEST)

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Following the detection of highly pathogenic avian influenza (HPAI) virus in countries bordering Kenya to the west, we conducted surveillance among domestic and wild birds along the shores of Lake Victoria. In addition, between 2018 and 2020, we conducted surveillance among poultry and poultry workers in live bird markets and among wild migratory birds in various lakes that are resting sites during migration to assess introduction and circulation of avian influenza viruses in these populations. We tested 7,464 specimens (oropharyngeal and cloacal swabs) from poultry and 6,531 fresh fecal specimens from wild birds for influenza A viruses by real-time RT-PCR. Influenza was detected in 3.9% (n=292) of specimens collected from poultry and 0.2% (n=10) of fecal specimens from wild birds. On hemagglutinin subtyping, most of the influenza A positives from poultry (274/292, 93.8%) were H9. Of 34 H9 specimens randomly selected for further subtyping, all were H9N2. On phylogenetic analysis, these viruses were genetically similar to other H9 viruses detected in East Africa. Only two of the ten influenza A positive specimens from the wild bird fecal specimens were successfully subtyped; sequencing analysis of one specimen collected in 2018 was identified as low pathogenicity avian influenza H5N2 virus of the Eurasian lineage and the second specimen, collected in 2020, was subtyped as H11. A total of 18 OP/NS swabs from poultry workers with ARI (12%) were collected; none were positive for influenza A virus. We observed significant circulation of H9N2 influenza viruses in poultry in live bird markets in Kenya. During the same period, low pathogenic H5N2 virus was detected in a fecal specimen collected in a site hosting a variety of migratory and resident birds. Although HPAI H5N8 was not detected in this survey, these results highlight the potential for introduction and establishment of highly pathogenic avian influenza viruses in poultry populations and the associated risk of spillover to human populations.

Preprint ARTICLE | doi:10.20944/preprints201701.0034.v1

Game Analysis of Low Carbonization for Urban Logistics Service Systems

Jidong Guo, Shugang Ma

Subject: Business, Economics And Management, Business And Management Keywords: 3PLs; E-business enterprise; low carbonization; game theory; Nash Equilibria

Online: 9 January 2017 (03:29:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0360.v1

Research on Electric Vehicle Power Systems Based on Digital Twin Technology

Chong Li, Mei Jian Lei, Liangyi Yang, Wei Xu, Yong You

Subject: Engineering, Automotive Engineering Keywords: Digital twin; Powertrain system; Para model; Functional testing; Fault injection

Online: 4 September 2024 (11:23:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0013.v1

Persons with Rheumatoid Arthritis Challenge the Relevance of the Health Assessment Questionnaire: A Qualitative Study of Patient Perception

David Ebbevi, Anna Essén, Helena Hvitfeldt Forsberg

Subject: Public Health And Healthcare, Nursing Keywords: Rheumatoid Arthritis; thematic analysis; Outcomes assessment; Qualitative Research; Patient reported outcome measures

Online: 3 January 2017 (11:32:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0032.v1

Assessment of Rural Flood Risk and Factors Influencing Household Flood Risk Perception in the Haut-Bassins Region of Burkina Faso, West Africa

Madou Sougué, Bruno Merz, Amadé Nacanabo, Gnibga Issoufou Yangouliba, Ibrahima Pouye, Jean Mianikpo Sogbedji, François Zougmoré

Subject: Environmental And Earth Sciences, Geography Keywords: Burkina Faso; flood risk index; flood risk perception index; influence factors; indicator-based method; ordered logistic modelling

Online: 1 May 2024 (07:31:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0078.v1

High Step-up Voltage Gain Converter with Ripple-free Input Current for Renewable Energy Sources

Zhangyong Chen, Yong Chen

Subject: Engineering, Electrical And Electronic Engineering Keywords: input current ripple-free; boost converter; coupled-inductor; voltage-doubler cell; passive lossless clamp circuits; high voltage gain; renewable energy

Online: 17 January 2017 (11:10:36 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202406.1994.v1

Novel Ultrasound-Guided Hydrodissection with 5% dextrose Techniques for the Treatment of Occipital Neuralgia Targeting the Greater Occipital Nerve

King Hei Stanley Lam, Daniel Chiung Jui Su, Yung−Tsan Wu, Aeneas Janze, Kenneth Dean Reeves

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Occipital neuralgia; Greater occipital nerve; Ultrasound-guided; Hydrodissection; 5% dextrose in sterile water; Suboccipital Headache,; third occipital nerve,; Cranial to caudal approach,

Online: 28 June 2024 (12:11:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1556.v1

Empirical Analysis of the Current Status and Potential of Service-oriented and Data-driven Business Models within the Sheet Metal Working Sector: Insights from Interview-based Research in SMEs

Jonas Wirth, Mirko Schneider, Leon Hanselmann, Kira Fink, Stephan Nebauer, Thomas Bauernhansl

Subject: Business, Economics And Management, Business And Management Keywords: service-oriented business models; data-driven business models; servitization; digital transformation; ecosystem innovation, SME

Online: 27 February 2024 (14:06:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1464.v1

Analysis of CDO, PITX2, and CDH13 gene methylation in early endometrial cancer for prediction of medical treatment outcomes

Aleksey M. Krasnyi, Lyubov T. Gadzhieva, Diana N. Kokoeva, Mark G. Kosenko, Ekaterina L. Yarotskaya, Stanislav V. Pavlovich, Levon A. Ashrafyan, Gennady Sukhikh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: methylation; atypical endometrial hyperplasia; endometrial cancer; organ-preserving treatment; MS-HRM; CDO1; CDH13

Online: 26 February 2024 (14:19:49 CET)

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An observational cohort study of patients diagnosed with endometrial cancer (EC) stage IA G1, or atypical endometrial hyperplasia (AHE), undergoing organ-preserving treatment, was conducted. Objective of the study: to determine CDO1, PITX2, and CDH13 gene methylation levels in early endometrial cancer and atypical hyperplasia specimens obtained before organ-preserving treatment in the patients with adequate response and with insufficient response to hormonal treatment. Materials and methods: 41 endometrial specimens obtained during diagnostic uterine curettage in women with EC (n=28) and AEH (n=13), willing to preserve reproductive function, were studied; 18 specimens of endometrial cancer IA stage G1 from peri- and early postmenopausal women (comparison group) were included in the study. The control group included 18 endometrial specimens from healthy women obtained by diagnostic curettage for missed abortion and/or intrauterine adhesions. Methylation levels were analyzed using the modified MS-HRM method. Results: All 13 women with AEH had complete response (CR) to medical treatment. In the group undergoing organ-preserving treatment for uterine cancer IA stage G1 (n=28), 14 patients had complete response (EC CR group) and 14 had not (non-CR). It was found that all groups had statistically significant differences in CDO1 gene methylation levels with the control group (p<0.001) except for the EC CR group (p=0.21). The p-value of difference between EC CR and EC non-CR groups was <0.001. The differences in PITX2 gene methylation levels between the control and study groups were also significantly different (p<0.001), except for AEH group (p=0.21). For the difference between EC CR and EC non-CR groups, the p-value was 0.43. For CDH13 gene methylation levels, statistically significant differences were found between the control and EC non-CR groups (p<0.001), and the control and EC comparison groups (p=0.005). When comparing the EC CR group with EC non-CR group, the p-value for this gene was <0.001. Simultaneous assessment of CDO1 and CDH13 genes methylation allowed to accurately distinguish between EC CR and EC non-CR groups (AUC=0.96). Conclusion: Assessment of CDO1 and CDH13 gene methylation in endometrial specimens from patients with endometrial cancer (IA stage G1), planned for medical treatment, can predict the treatment outcome.

Preprint COMMUNICATION | doi:10.20944/preprints202406.0431.v1

Raman Study of Novel Walls-like Nanostructured WO3 Thin Films Grown by Spray Deposition

Andreea Gabriela Marina Popescu, Ioan Valentin Tudose, Cosmin Romanitan, Marian Popescu, Marina Manica, Paul Schiopu, Mirela Petruta Suchea, Cristina Pachiu

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Raman spectroscopy; tungsten oxide; spray pyrolysis; thin films

Online: 7 June 2024 (08:05:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0584.v1

Tuscan Archipelago National Park: Preservation and Valorization of Local Landraces of Brassica and Phaseolus Species

Lorella Andreani, Andrea Venturini, Giulia Spada, Giovanna Amorosi, Giuliana Gillone, Carolina Maria Miarelli, Fabiano Camangi, Agostino Stefani, Chiara Delogu

Subject: Biology And Life Sciences, Other Keywords: landrace; local germplasm; on-farm conservation; Biosphere Reserve; custodian farmers; SSR markers, population structure

Online: 8 April 2024 (17:00:23 CEST)

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The maintenance of traditional agricultural practices in protected small islands is closely linked to the preservation of the land, the protection of natural resources, and the conservation of local traditions. For this purpose, the Tuscan Archipelago National Park promoted the census of ancient horticultural varieties preserved by some farmers on the island of Elba. The survey revealed a deep-rooted historical, cultural, social, and economic link between this germplasm and the island’s territory. A scientific characterization of the landrace under ethnobotanical, morphological, and genetic aspects was carried out. Among these local varieties, two landraces of the Brassica species and three landraces of the Phaseolus species were identified and analyzed in this study. To ascertain their distinguishability and uniqueness, similar varieties were also identified based on morpho-physiological characteristics or territorial proximity and compared with the Elban landraces. Morpho-phenological data were collected, and molecular analyses were carried out using Simple Sequence Repeats (SSR) markers. Ten different SSR loci were considered for the Phaseolus species and nine for the Brassica species. The Tuscan Archipelago landraces showed a high level of internal variability but were clearly distinct from each other and from the analyzed varieties, as shown by AMOVA (Analysis of Molecular Variance). Their distinctness was further highlighted by the UPGMA dendrogram obtained from the genetic distance matrix. The same results were confirmed by Principal Coordinate Analysis (PCoA). This study confirms the peculiarity of the Elban landraces, their biodiversity is a heritage to be safeguarded, which can also be used in future breeding programs. These ancient Elban landraces were allocated to local farmers (most were young farmers) to protect them from extinction and to promote more resilient varieties cultivation compared to commercial hybrids widely spread in the area. Local farmhouses also play a strategic role in safeguarding the germplasm and dissemination of sustainable agricultural practices. There is high demand for ancient Elban landraces, this has led to the development of a new local economy balanced between agricultural tradition and innovation.

Preprint ARTICLE | doi:10.20944/preprints201610.0037.v1

A Multi-Objective Collection-Distribution Center Location and Allocation Problem in a Closed-Loop Supply Chain for the Chinese Beer Industry

Kang Kai, Xiaoyu Wang, Yanfang Ma

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: collection-distribution center; closed loop supply chain; fuzzy random variable; particle swarm optimization

Online: 11 October 2016 (11:02:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0747.v1

Battery Management for Improved Performance in Hybrid Electric Vehicles

Carlos Armenta-Déu

Subject: Engineering, Automotive Engineering Keywords: Hybrid Electric Vehicle; Battery Management; Performance Enhancement; Energy consumption rate; Vehicle Speed

Online: 11 April 2024 (12:50:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1705.v1

MixDeR: A SNP Mixture Deconvolution Workflow for Forensic Genetic Genealogy

Rebecca Mitchell, Michelle Peck, Erin Gorden, Rebecca Just

Subject: Biology And Life Sciences, Other Keywords: mixtures; SNPs; forensic genetic genealogy (FGG); investigative genetic genealogy (IGG); Kintelligence; software

Online: 24 July 2024 (14:45:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1660.v1

Antidiabetic Effect of Raru (Vatica perakensis) Bark Extract and Mocaf Activated Carbon in Streptozotocin-Induced Diabetic Rats

Gunawan Pasaribu, Novitri Hastuti, Saptadi Darmawan, Gustan Pari, Lisna Efiyanti, Totok Waluyo, Mody Lempang, Yelin Adalina

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: antidiabetic, extract, in-vivo, MAC, raru ; ;

Online: 25 April 2024 (10:17:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0998.v1

Whole Genome Sequencing of Human and Porcine Escherichia coli Isolates on a Commercial Pig Farm in South Africa

Wilhelmina Strasheim, Michelle Lowe, Anthony M Smith, Eric MC Etter, Olga Perovic

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Escherichia coli; pigs; close human contacts; One Health; antibiotic resistance; whole genome sequencing; virulence factors; core genome MLST and hierarchical clustering; sequence type complex 10; South Africa

Online: 15 May 2024 (04:32:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0920.v1

The Diagnostic Challenge of Cystic Echinococcosis in Humans: First Assessment of Underreporting Rates in Mongolia

Bolor Bold, Christian Schindler, Uranshagai Narankhuu, Agiimaa Shagj, Erdenebileg Bavuujav, Sonin Sodov, Tsogbadrakh Nyamdorj, Jakob Zinsstag

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: cystic echinococcosis 1; Mongolia 2; clinical guideline 5; burden of disease 6; Echinococcus granulosus 6

Online: 13 June 2024 (14:54:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1011.v1

Individualized Management of Postoperative Radiotherapy for Patients with Diffuse Low-Grade Gliomas

Xin Zhang, Wenbo Wu, Yu Wang, Xin Lian, Wenbin Ma

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Diffuse Low-Grade Glioma; Postoperative Radiotherapy; Individualized Treatment; Timing of Radiotherapy; Cognitive Decline

Online: 14 August 2024 (08:20:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1616.v1

Mobile Spatiotemporal Gait Segmentation Using an Ear-Worn Motion Sensor and Deep Learning

Julian Decker, Lukas Boborzi, Roman Schniepp, Klaus Jahn, Max Wuehr

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: gait analysis; inertial sensor; ear; earable; in-ear sensing; vital sign monitoring; wearables; deep learning

Online: 22 August 2024 (06:01:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0250.v1

Human Activity Recognition in a Free-Living Environment Using an Ear-Worn Motion Sensor

Lukas Boborzi, Julian Decker, Razieh Rezaei, Roman Schniepp, Max Wuehr

Subject: Computer Science And Mathematics, Signal Processing Keywords: human activity recognition; inertial sensor; ear; in-ear sensing; vital sign monitoring; wearables; machine learning; deep learning

Online: 3 April 2024 (11:06:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1986.v1

Nerve Growth Factor Signaling Modulates the Expression of Glutaminase in Dorsal Root Ganglion Neurons during Peripheral Inflammation

Vikramsingh Gujar, Radhika D Pande, Bhalchandra M Hardas, Subhas Das

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Inflammation; Nerve growth factor (NGF); peripheral Inflammation, Nociception, NGF-TrkA signaling, Dorsal root ganglion, Glutaminase, Rab7, Rab7GTPase

Online: 30 April 2024 (11:49:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2144.v1

Success Factors for Returnee Migrant Entrepreneurs in Ethiopia: The Mediating Role of Government Policies and Institutional Support

Biru Desta Kassaye, Yitbarek Takele Bayiley, Zerihun Kindie Alemu

Subject: Business, Economics And Management, Business And Management Keywords: Returnee Migrants; Entrepreneurial Success; Success Factors; Government Policies; Institutional Support; Ethiopia

Online: 26 July 2024 (13:05:50 CEST)

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In recent years, Ethiopia's number of returnee entrepreneurs has increased dramatically, significantly contributing to personal financial achievement and the nation's economic development and transformation. However, their businesses are typically smaller and less profitable than non-migrant entrepreneurs. This study explores factors affecting the success of these returnee migrant entrepreneurs, including individual characteristics, entrepreneurial skills, and experience, financial resources, as well as the mediating role of government policies and institutional support. Data was collected from 390 returnee migrants who started their businesses and analyzed using a robust theoretical foundation and PLS-SEM to understand the impact of success factors. The results show that entrepreneurial skills, experience, and financial resources positively and significantly influence the success of returnee migrant entrepreneurs. Furthermore, social networks, while not directly significantly influencing the entrepreneurial success of returnee migrants are mediated by government policies and institutional support. Professional guidance and counseling provided by experts and mentors of the accelerator program were found to be essential for entrepreneurial success but did not improve the effectiveness of the policy. Financial resources, although crucial, did not significantly impact policy efficacy. These findings underscore the need for tailored policy interventions addressing the challenges faced by returnee migrants, including economic self-sufficiency, socio-psychological support, and effective social networks to boost the success of returnee migrants. Experienced returnee entrepreneurs play a key role in developing a vigorous and supportive entrepreneurial ecosystem through community engagement and policy advocacy. Additionally, personal traits are crucial for entrepreneurial success, while practical experience influences government policies for substantiated policy development in returnee migrant entrepreneurship and its benefits.

Preprint ARTICLE | doi:10.20944/preprints201609.0058.v1

The Political Economy of Russian Migration Politics

Vladimir Malakhov, Mark Simon

Subject: Business, Economics And Management, Economics Keywords: labor migration; migration policy; Russia; Post-Soviet space; governmentality; labor legalization

Online: 18 September 2016 (09:45:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0080.v1

A Parameter Selection Method for Wind Turbine Health Management through SCADA Data

Mian Du, Jun Yi, Peyman Mazidi, Lin Cheng, Jianbo Guo

Subject: Engineering, Electrical And Electronic Engineering Keywords: wind turbine; failure detection; SCADA data; feature extraction; mutual information; copula

Online: 17 January 2017 (11:21:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0030.v1

Surface Ages in the Vicinity of the Chang’e-6 Landing Site

Li Zhang, Jianzhong Liu, Gregory Michael, Ping Ge, Kaichang Di, Congzhe Wu, Kai Zhu, Xiaoxi Kang

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Chang’ e-6; CSFD measurements; absolute model age; Apollo basin

Online: 2 September 2024 (08:54:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0025.v1

Influence of the Selection of the Electric Motor/Engine Assembly on Dynamic Performances and Fuel Consumption of Hybrid Vehicles

Olivian Chiver, Ioan Radu Sugar, Liviu Neamt

Subject: Engineering, Transportation Science And Technology Keywords: ADVISOR software; electric motor/engine; hybrid vehicle; performance

Online: 4 June 2024 (02:53:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0734.v1

Validation of OLCI Sentinel-3 water products in the Baltic Sea and evaluating the effect of System Vicarious Calibration (SVC)

Sean O’Kane, Tim McCarthy, Rowan Fealy, Susanne Kratzer

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: OLCI; Sentinel-3; C2RCC; System Vicarious Calibration (SVC); Baltic Sea; Coloured Dissolved Organic Matter (CDOM); Chlorophyll-a; Total Suspended Matter (TSM)

Online: 12 August 2024 (11:25:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2010.v1

Predictive AI Models for Energy Efficiency in Hybrid and Electric Vehicles: Analysis for Enna, Sicily

Maksymilian Mądziel, Tiziana Campisi

Subject: Engineering, Transportation Science And Technology Keywords: vehicles; EV; Energy consumption; predictive modelling; Italy; artificial intelligence

Online: 25 July 2024 (09:09:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0851.v1

Greening the Grassroots: Evaluating Environmental Management in Nigeria's Small and Medium-Sized Enterprises

Sunday Amiolemen, Olapeju Adenekan, Idowu Ologeh, Koleayo Omoyajowo, Oluseye Oludoye, Morufu Raimi

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Environmental Management; SMEs; Environmental pollution; Eco-friendly innovation; Sustainable development

Online: 10 July 2024 (12:58:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2546.v1

Dynamics of Mammarenavirus Wenzhouense Acute Infection in the Rodent Rattus norvegicus

ShanShan Du, XueFei Deng, Xiaoxia Huang, TieZhu Liu, Aqian Li, Qin Wang, TingTing Tian, Chuan Li, ZhangQi Zheng, QiHan Lin, ZhuoWei Li, Shiwen Wang, Jiandong Li

Subject: Public Health And Healthcare, Other Keywords: Wenzhou virus; acute infection; virus shedding, transmission; rodents; arenavirus

Online: 31 July 2024 (15:21:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2004.v1

An Innovation Management Approach for Electric Vertical Take-off and Landing

Tingyou LI, Luyi Shen, Xia Xu

Subject: Business, Economics And Management, Business And Management Keywords: Electric Vertical Take-off and Landing; Technology Roadmapping; Technology Adoption Life Cycle; DEMATEL

Online: 25 July 2024 (09:29:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1015.v1

Wheat Straw Ash and Silica Fume Replacing Model for Lowering the Carbon Footprint of Cement Paste

Bryan Bastías, Marcelo González, Guillermo Valerio, Pablo Guindos

Subject: Engineering, Architecture, Building And Construction Keywords: sustainable concrete; cement paste; design of experiment; silica fume; wheat straw ash; low carbon; supplementary cementitious material; Box-Behnken Design.

Online: 14 June 2024 (15:33:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0189.v1

Promoting Effect of Inorganic Alkali on Carbon Dioxide Adsorption in Amine-Modified MCM-41

Yang Teng, Lijiao Li, Gang Xu, Kai Zhang, Kaixi Li

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: amine-modified MCM-41; CO2 adsorption; inorganic alkali; alkali amounts

Online: 22 August 2016 (05:47:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0476.v1

Public Service Provisions for Land Resource Planning in Khao Phanom, Krabi Province in Thailand

Teeraphat Kitjarak, Shubham Pathak, Xinlin Qi, Thussaneeya Boripis

Subject: Social Sciences, Government Keywords: Land resource planning; Plant genetic resources; Policy implementation; Public service; Thailand 4.0

Online: 6 July 2024 (04:50:10 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202409.0501.v1

Prospect on Damage Control in Current ASD Intervention

Qi Zhang, Qiang Li

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism; Immune stress; Brain damage; Damage control

Online: 6 September 2024 (09:40:08 CEST)

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