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Preprint REVIEW | doi:10.20944/preprints202404.0380.v1

Obesogens in Adolescence. Challenging Aspects and Prevention Strategies.

Marina Nicolaou, Meropi Toumba, Alexandros Kythreotis, Habib Daher, Nicos Skordis

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: endocrine disrupting chemicals; obesogens; obesity; children; adolescents; prevention strategies

Online: 5 April 2024 (06:51:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0041.v1

Hunting the Cell Cycle Snark

Vic Norris

Subject: Biology And Life Sciences, Life Sciences Keywords: cell division; bacteria; hyperstructure; water; phase separation; condensate; origins of life; chromosome replication; phenotypic diversity; differentiation

Online: 1 August 2024 (12:38:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1513.v1

Agricultural Disaster Prevention System: A Review of the Strategies in Taiwan

Ming-Hwi Yao, Yung-Heng Hsu, Ting-Yi Li, Yung-Ming Chen

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: weather forecast; early warning system; disaster prevention; crop; information and communication technology (ICT)

Online: 27 February 2024 (10:29:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0033.v1

Establish and Apply a Safe and Convenient Pseudovirus-Based Assay to Detect Neutralizing Antibodies against Influenza A (H7N9) Virus

Li Zhang, Jing Lu, Jingxing Li, Rong Tang, Haiyan Peng, Fanyue Meng, Yuemei Hu

Subject: Biology And Life Sciences, Virology Keywords: H7N9 avian influenza; pseudovirus; neutralization assay; relative luminescence units (RLU)

Online: 6 January 2017 (10:21:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.0752.v1

Dietary Exposure to Pesticide and Veterinary Drugs Residues and Their Effects on Human Fertility and Embryo Development: A Global Overview

Ambra Colopi, Eugenia Guida, Silvia Cacciotti, Serena Fuda, Matteo Lampitto, Angelo Onorato, Alice Zucchi, Carmela Rita Balestrieri, Paola Grimaldi, Marco Barchi

Subject: Biology And Life Sciences, Life Sciences Keywords: food contaminants; transgenerational inheritance; organophosphates; glyphosate; antibiotics; active pharmaceutical ingredients

Online: 13 August 2024 (03:18:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1491.v1

Review on the Impact of Iron Tailings on the Environment and Its Prevention and Control Strategies

Yunjie Bai, Weixing Liu, Aimin Yang, Bo Gao, Hao Li, Zhixiao Lin

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Iron tailings; Environmental impact; Water pollution; Air pollution; Resource utilization

Online: 23 May 2024 (10:37:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0180.v1

The Distal Promoter of the B438L Gene of African Swine Fever Virus Is Responsible for the mRNA Transcription of the B438L and the Alternatively Spliced B169L

Hongwei Cao, Hao Deng, Yanjin Wang, Diqiu Liu, Lian-Feng Li, Meilin Li, Dingkun Peng, Jingwen Dai, Jiaqi Li, Hua-Ji Qiu, Su Li

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: African swine fever virus; B438L promoter; transcription initiation; B169L protein

Online: 3 May 2024 (09:46:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0429.v1

Timber-Based Strategies for Seismic Collapse Prevention and Energy Performance Improvement in Masonry Buildings

Davide Cassol, Maja Danovska, Alessandro Prada, And Ivan Giongo

Subject: Engineering, Civil Engineering Keywords: unreinforced masonry; seismic retrofit; energy efficiency; timber panels; timber strong-backs; thermal transmittance u-value; periodic thermal properties; transient method; response factors

Online: 7 November 2023 (09:32:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0030.v2

Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China

Chao Wang, Shuang Li, Tao Li, Shanfa Yu, Junming Dai, Xiaoman Liu, Xiaojun Zhu, Yuqing Ji, Jin Wang

Subject: Social Sciences, Psychology Keywords: occupational stress; job burden-capital model; structural equation model; depression; well-being

Online: 4 August 2016 (12:47:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1104.v1

MR protocol optimization for Hepatobiliary Phase Imaging with Gadoxetic Acid for 1.5T: Comparison Between Breath-Hold T1-weighted and High Resolution Navigated 3D T1-weighted sequences

Eliseo Picchi, Valentina Ferrazzoli, Valeria Liberto, Luca Toti, Raffaella Giocondo, Valerio Da Ros, Noemi Pucci, Silvia Minosse, Francesco Garaci, Francesca Di Giuliano

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Magnetic Resonance; Gadoxetic Acid; High Resolution Navigated 3D; Hepatocarcinoma

Online: 17 June 2024 (08:06:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1578.v1

TransPerineal Laser Ablation (TPLA) Treatment of Focal Low-Intermediate Risk Prostate Cancer

Guglielmo Manenti, Tommaso Perretta, Marco Nezzo, Federico Romeo Fraioli, Beatrice Carreri, Paola Elda Gigliotti, Andrea Micillo, Andrea Malizia, Daniele Di Giovanni, Colleen Patricia Ryan, Francesco Giuseppe Garaci

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: mpMRI; prostate cancer; TPLA; FLA; focal laser ablation; transperineal laser ablation

Online: 28 February 2024 (04:48:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2546.v1

Dynamics of Mammarenavirus Wenzhouense Acute Infection in the Rodent Rattus norvegicus

ShanShan Du, XueFei Deng, Xiaoxia Huang, TieZhu Liu, Aqian Li, Qin Wang, TingTing Tian, Chuan Li, ZhangQi Zheng, QiHan Lin, ZhuoWei Li, Shiwen Wang, Jiandong Li

Subject: Public Health And Healthcare, Other Keywords: Wenzhou virus; acute infection; virus shedding, transmission; rodents; arenavirus

Online: 31 July 2024 (15:21:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1291.v1

Development of Smallpox Antibody Testing and Surveillance Following Smallpox Vaccination in the Republic of Korea

Hwachul Shin, SangEun Lee, Myung-Min Choi, Hwajung Yi, Yoon-Seok Chung

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: smallpox; Vaccinia virus; smallpox vaccine; antibody titer; ELISA; bioterrorism

Online: 20 August 2024 (04:55:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0600.v1

Characterization of Avian Influenza Viruses Detected in Kenyan Live Bird Markets and Wild Bird Habitats Reveal Genetically Diverse Subtypes and High Proportion of A(H9N2), 2018-2020

Peninah Munyua, Eric Osoro, Joyce Jones, George Njogu, Genyan Yang, Elizabeth Hunsperger, Christine Szablewski, Ruth Njoroge, Doris Marwanga, Harry Oyas, Ben Andagalu, Romona Ndanyi, Nancy Otieno, Vincent Obanda, Carolyne Nasimiyu, Obadiah Njagi, Juliana DaSilva, Yunho Jang, John R Barnes, Gideon Emukule, Clayton Onyango, Charles Davis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Africa; surveillance; poultry diseases; avian influenza; low pathogenic

Online: 8 August 2024 (08:53:37 CEST)

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Following the detection of highly pathogenic avian influenza (HPAI) virus in countries bordering Kenya to the west, we conducted surveillance among domestic and wild birds along the shores of Lake Victoria. In addition, between 2018 and 2020, we conducted surveillance among poultry and poultry workers in live bird markets and among wild migratory birds in various lakes that are resting sites during migration to assess introduction and circulation of avian influenza viruses in these populations. We tested 7,464 specimens (oropharyngeal and cloacal swabs) from poultry and 6,531 fresh fecal specimens from wild birds for influenza A viruses by real-time RT-PCR. Influenza was detected in 3.9% (n=292) of specimens collected from poultry and 0.2% (n=10) of fecal specimens from wild birds. On hemagglutinin subtyping, most of the influenza A positives from poultry (274/292, 93.8%) were H9. Of 34 H9 specimens randomly selected for further subtyping, all were H9N2. On phylogenetic analysis, these viruses were genetically similar to other H9 viruses detected in East Africa. Only two of the ten influenza A positive specimens from the wild bird fecal specimens were successfully subtyped; sequencing analysis of one specimen collected in 2018 was identified as low pathogenicity avian influenza H5N2 virus of the Eurasian lineage and the second specimen, collected in 2020, was subtyped as H11. A total of 18 OP/NS swabs from poultry workers with ARI (12%) were collected; none were positive for influenza A virus. We observed significant circulation of H9N2 influenza viruses in poultry in live bird markets in Kenya. During the same period, low pathogenic H5N2 virus was detected in a fecal specimen collected in a site hosting a variety of migratory and resident birds. Although HPAI H5N8 was not detected in this survey, these results highlight the potential for introduction and establishment of highly pathogenic avian influenza viruses in poultry populations and the associated risk of spillover to human populations.

Preprint REVIEW | doi:10.20944/preprints202305.1230.v1

Nutritional Strategies for the Prevention and Management of NAFLD in Postmenopausal Women

Johanna K DiStefano

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: nonalcoholic fatty liver disease; heterogeneity; women; menopause; estrogen; nutrition; choline; soy isoflavones; probiotics

Online: 17 May 2023 (10:30:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2238.v2

Challenges and Advances in Cervical Cancer Prevention for HIV-Positive Individuals

Angel Justiz-Vaillant, Darren Gopaul, Reinand Thompson, Odalis Asin-Milan, Rodolfo Arrozarena-Fundora, Sachin Soodeen, Chandrashekhar Unakal

Subject: Virology, Biology And Life Sciences Keywords: HPV; Prevalence; Vaccination strategy; HPV screening; Cervical intraepithelial neoplasia

Online: 19 September 2024 (11:47:05 CEST)

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Since the identification of acquired immunodeficiency syndrome (AIDS) in 1981, approximately 85.6 million people have been infected with HIV, resulting in 40.4 million deaths. As of 2022, 53% of the 39 million people living with HIV are women and girls. Despite the advent of antiretroviral therapy (ART) improving survival rates, cervical cancer remains prevalent among HIV-infected individuals. By 2030, cervical cancer is projected to cause 727,500 new cases and 432,000 deaths globally. Human papillomavirus (HPV) is a well-known cause of cervical cancer, with HIV infection exacerbating the prevalence of high-risk HPV (HR-HPV) and cervical intraepithelial neoplasia (CIN). HIV and HPV share transmission routes, and HIV worsens cervical carcinogenesis by inhibiting tumour suppressor genes and altering cell cycle regulation. Chronic inflammation and cytokine imbalances, notably increased IL-10 levels, are linked to cervical cancer progression. Despite ART improving overall health, cervical cancer remains a significant issue, highlighting the need for better screening and prevention measures. A cross-sectional study in Brazil evaluated cytokine levels in cervicovaginal lavage among HIV-positive women, revealing a high prevalence of specific HPV types. ART has been shown to reduce the likelihood of developing squamous intraepithelial lesions (SILs) and HR-HPV prevalence, although its impact on invasive cervical cancer remains inconclusive. In a study in Accra, 250 sexually active HIV-positive women exhibited a high HPV prevalence, emphasising the need for regular screening. HPV testing, visual inspection with acetic acid (VIA), and cytology-based tests are primary screening methods, each with specific advantages and limitations. A systematic review and meta-analysis indicated that ART is associated with a lower prevalence of HR-HPV and high-grade cervical lesions, suggesting that early ART initiation may reduce cervical lesion incidence and progression. HPV is a significant cause of sexually transmitted diseases, with high prevalence in sub-Saharan Africa. Studies show a substantial burden of HPV among men in the region, underscoring the potential benefits of HPV vaccination programs. A study in Tanzania highlighted a high prevalence of HR-HPV among HIV-positive men, suggesting the efficacy of HPV vaccines irrespective of HIV status. Cervical cancer rates in sub-Saharan Africa are alarmingly high, necessitating targeted vaccination and prevention strategies.

Preprint REVIEW | doi:10.20944/preprints202402.1430.v1

An overview of Monkeypox Virus: Molecular Biology, Epidemiology, Pathogenesis, Treatment and Prevention Strategies

Nazim Hussain, Muhammad Hamza Ashraf, Rabia Arooj, Iqra Arif, Rimsha Haqqi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Monkeypox virus; Orthopoxvirus; Epidemiology; Zoonotic sources; Diagnosis; Treatment

Online: 26 February 2024 (12:09:39 CET)

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Preprint REVIEW | doi:10.20944/preprints201806.0063.v1

Strategies to Engage Adolescents in Digital Health Interventions for Obesity Prevention and Management

Stephanie R Partridge, Julie Redfern

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: engagement; adolescents; obesity; diet; prevention; management

Online: 5 June 2018 (11:21:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1249.v1

Frailty Syndrome: A Global Perspective on Prevalence, Challenges, and Strategies for Prevention and Management

Richard Murdoch Montgomery

Subject: Public Health And Healthcare, Primary Health Care Keywords: Frailty syndrome; Geriatric medicine; Sarcopenia; Muscle strength exercises; Biomarkers; Electroencephalography (EEG); Healthcare costs; Global aging

Online: 17 September 2024 (06:15:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1232.v1

Feasibility of Emergency Flood Traffic Road Damage Assessment by Integrating Remote Sensing Images and Social Media Information

Hong Zhu, Jian Meng, Jiaqi Yao, Nan Xu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Multi-source heterogeneity; Flood disaster; Social media information; TextCNN-Attention; Transportation roads; Loss assessment

Online: 19 August 2024 (04:33:27 CEST)

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In the context of global climate change, the frequency of sudden natural disasters is increasing. Assessing traffic road damage post-disaster is crucial for emergency decision-making and disaster management. Traditional ground observation methods for evaluating traffic road damage are limited by the timeliness and coverage of data updates. Relying solely on these methods does not adequately support rapid assessment and emergency management during extreme natural disasters. Social media, a major source of big data, can effectively address these limitations by providing more timely and comprehensive disaster information. Motivated by this, we utilized multi-source heterogeneous data to assess the damage to traffic roads under extreme conditions and established a new framework for evaluating traffic roads in cities prone to flood disasters caused by rainstorms. The approach involves several steps: First, extracting the surface area affected by precipitation using a threshold method constrained by confidence intervals derived from microwave remote sensing images; Second, collecting disaster information from the Sina Weibo platform, where social media information is screened and cleaned. A quantification table for road traffic loss assessment was defined, and a social media disaster information classification model combining text convolutional neural networks and attention mechanisms was proposed (TextCNN-Attention Disaster Classification); Finally, matching traffic road information on social media with basic geographic data, visualizing the classification of traffic road disaster risk levels, and completing the assessment of traffic road disaster levels based on multi-source heterogeneous data. Using the "7.20" rainstorm event in Henan Province as an example, this study categorizes the disaster impact on traffic roads into five levels: particularly severe, severe, moderate, mild, and affected, as interpreted from remote sensing images. The evaluation framework for flood disaster traffic roads based on multi-source heterogeneous data provides important data support and methodological support for enhancing disaster management capabilities and systems.

Preprint ARTICLE | doi:10.20944/preprints202403.0440.v1

Partial Substitution of Chemical N with Solid Cow Manure Improved Soil Ecological Indicators and Crop Yield in a Wheat-Rice Rotation System

Jintao Yu, Chun Zhang, Xuan Wang, Hongchuan Li, Yusef Kianpoor Kalkhajeh, Hongxiang Hu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: conventional fertilization; solid cow manure; crop quality; soil nutrients; ecological risk

Online: 7 March 2024 (13:10:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1060.v1

Assessment of Earthquake Damage and Economic Recovery in Hatay Province, Turkey Using Nighttime Light Data

Feng Li, Shunbao Liao, Xiaobo Zhang, Tianxuan Liu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: rapid assessment method; Turkey earthquake damage; economic recovery assessment; Hatay Province; nighttime light; NPP-VIIRS; SDGSAT-1

Online: 12 July 2024 (13:50:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1272.v1

Exploring the Interrelationships Between Diabetes, Nutrition, Anxiety, and Depression: Implications for Treatment and Prevention Strategies

Raedeh Basiri, Blessing Seidu, Mark Rudich

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Diabetes; mental health; anxiety; depression; supplementation; nutrition; chronic disease; blood glucose; cardiovascular health; integrative medicine; mental disorders; nutrition education; life-style medicine

Online: 19 July 2023 (12:10:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1019.v1

A Rationally Designed H5 Hemagglutinin Subunit Vaccine Provides Broad-Spectrum Protection against Various H5Nx highly Pathogenic Avian Influenza Viruses in Chickens

Xuxiao Zhang, Xin Li, Fushou Zhang, Xiaoping Cui, Xiaoqin Guo, Zhi Sun, Pengju Guo, Ming Liao, Ning Chen

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: avian influenza virus; H5 subtype; subunit vaccine; broad protection

Online: 12 July 2024 (08:42:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0538.v1

Wastewater-Based Epidemiology for SARS-CoV-2 in Northern Italy: A Spatiotemporal Model

Matilde Fondriest, Lorenzo Vaccari, Federico Aldrovandi, Laura De Lellis, Filippo Ferretti, Carmine Fiorentino, Erica Mari, Maria Grazia Mascolo, Laura Minelli, Vincenza Perlangeli, Giuseppe Bortone, Paolo Pandolfi, Annamaria Colacci, Andrea Ranzi

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Wastewater-based epidemiology; SARS-CoV-2; COVID-19; wastewater; biodegradation; sewer network; spatiotemporal model; public health; early-warning system

Online: 8 April 2024 (14:48:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1450.v1

Stat3 Inhibitors TTI-101 and SH5-07 Suppress Bladder Cancer Cell Survival In 3D Tumor Models

Surya Pratap Singh, Gopal Pathuri, Adam S Asch, Chinthalapally V. Rao, Venkateshwar Madka

Subject: Biology And Life Sciences, Life Sciences Keywords: Bladder cancer; STAT3 inhibitor; Apoptosis; Preclinical; 3D models

Online: 17 July 2024 (14:18:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0029.v1

Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review.

Renate Viebahn-Haensler, Olga León Fernández

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: redox bioregulation; mitochondriopathies; low-dose ozone concept; ozone therapy; oxidative stress; antioxidant capacity

Online: 1 May 2024 (07:29:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0026.v1

Molecular Prevalence, Genetic Diversity, and Tissue Tropism of Bartonella Species in Small Mammals from Yunnan Province, China

Pei-Yu Han, Fen-Hui Xu, Jia-Wei Tian, Jun-Ying Zhao, Ze Yang, Wei Kong, Bo Wang, Li-Jun Guo, Yun-Zhi Zhang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Bartonella; small mammals; genetic diversity; evolution; tissue tropism

Online: 1 April 2024 (17:07:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1633.v1

Bioinformatic Analysis of Topoisomerase IIa Reveals Interdomain Interdependencies and Critical C-Terminal Domain Residues

Clark E. Endsley, Kori A. Moore, Thomas D. Townsley, Kirk K. Durston, Joseph E. Deweese

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: topoisomerase II; cancer; bioinformatics; intrinsically-disordered domain; interdependency; DNA; topology; protein structure.

Online: 26 March 2024 (16:36:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.0360.v1

Infection Prevention and Control (IPC) Strategies According to the Type of Multidrug Resistant (MDR) Bacteria and Candida Auris in Intensive Care (ICU): A Pragmatic Resume, Pathogens R0, and Cost-Effectiveness Analysis

Chiara Fanelli, Laura Pistidda, Pierpaolo Terragni, Daniela Pasero

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Infection prevention and control; hospital-acquired infections; outbreak; multidrug resistant bacteria; acinetobacter baumanii; candida auris; vre; kpc; basic reproduction number; decolonization

Online: 3 July 2024 (16:11:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0438.v1

Title: Prevention of COVID-19. Part 1: Non-pharmacological Strategies and Interventions for Effective Disease Control

Ludwig Serge Aho Glele

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Covid-19; SARS-CoV-2; prevention; non-pharmacological interventions; standard precautions; airborne and droplet transmission; personal protective equipment; mask; ventilation; room occupancy; testing for SARS-CoV-2

Online: 4 August 2023 (12:08:52 CEST)

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(1) Background: The COVID-19 pandemic had a devastating impact on the world, causing widespread illness and death. It is essential to focus on prevention strategies to limit the spread of the disease. Despite the advent of vaccines, maintaining a vigilant approach to prevention remains paramount. While vaccines are essential, they do not guarantee absolute immunity, and their protective effect may diminish over time; (2) Methods: We reviewed effective strategies to prevent COVID-19 transmission. We focused on me-ta-analyses (MA), literature reviews (LR) and the health care context. Various prevention measures and interventions were reviewed. Both es-tablished practices and unresolved issues were considered; (3) Results: Standard precautions (SP) as the cornerstone of infection control, with hand hygiene and mask use as key components. Debate about the relative importance of droplet versus aerosol transmission led to differences in recommendations between agencies at the onset of the pandemic. We have clarified the role of personal protective equipment (PPE), including eye protection. The effectiveness of masks in pre-venting transmission is reviewed. The use of surgical masks is recommended to prevent droplet transmission, while eye protection is recommended in combination with masks. Although data show some risk reduction, the clear superiority of N95/FFP2 over surgical masks remains unproven. In terms of room occupancy, ventilation is critical in reducing the risk of transmission in poorly ventilated environments. The use of negative pressure isolation rooms (NPIRs) is being investigated. The presence of viral RNA on surfaces does not necessarily indicate infectivity, and the risk of transmission by surface contact is low if surfaces are properly maintained and hand hygiene is practised regularly. Testing for SARS-CoV-2 in asymptomatic persons in healthcare settings may help prevent transmission; (4) Conclusions: Prevention of SARS-CoV-2 transmission requires a multifaceted approach, including reducing particle emissions from infected persons by wearing masks, eliminating aerosols by ventilation, ensuring physical separation, and protecting exposed persons with masks and eye protection.

Preprint REVIEW | doi:10.20944/preprints202006.0086.v2

An Overview of Basic Molecular Biology of SARS-CoV-2 and Current COVID-19 Prevention Strategies

Ankur Das, Raja Ahmed, Suraiya Akhtar, Khaleda Begum, Sofia Banu

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Genome organisation and expression; Polyproteins; Prevention strategies

Online: 14 June 2020 (16:49:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0034.v1

Game Analysis of Low Carbonization for Urban Logistics Service Systems

Jidong Guo, Shugang Ma

Subject: Business, Economics And Management, Business And Management Keywords: 3PLs; E-business enterprise; low carbonization; game theory; Nash Equilibria

Online: 9 January 2017 (03:29:14 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202409.0501.v1

Prospect on Damage Control in Current ASD Intervention

Qi Zhang, Qiang Li

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism; Immune stress; Brain damage; Damage control

Online: 6 September 2024 (09:40:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0218.v1

Scaling Up Obesity and NCD Prevention in the Eastern Mediterranean Region through Fat Reduction Intake Strategies at Population Levels

Ayoub Al Jawaldeh, Hanin Al-Jawaldeh

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: NCD; Eastern Mediterranean region; Fat; SFA; TFA

Online: 17 April 2018 (06:24:29 CEST)

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NCDs are the leading cause of mortality globally which estimated 40 million death per year (68% of total death), with cardiovascular diseases, cancers, chronic respiratory diseases and diabetes. In the Eastern Mediterranean Region (EMR), around 60% of all deaths are attributed to NCDs. Two-thirds of NCD premature deaths are linked to 4 shared modifiable behavioural risk factors: tobacco use, unhealthy diet, physical inactivity and harmful use of alcohol. These unhealthy behaviours lead to 4 key metabolic/biological changes that increase the risk of NCDs: raised blood pressure, overweight/obesity, high blood glucose levels/diabetes, and hyperlipidemia (high levels of fat in the blood). Globally, countries are already working towards agreed global goals on maternal and infant nutrition and on the prevention of NCDs, and both these include halting the increase in overweight and obesity and reducing NCD diet-related risk factors including reducing saturated fatty acids (SFA) and Trans fatty acid (TFA) intake. According to values reported for countries of the Eastern Mediterranean Region, average SFA intake is estimated at 10.3% of energy intake (EI), thus exceeding the WHO recommended level of 10% EI. Average TFA intake in EMR countries is estimated at 1.9% EI, which also exceeds the WHO recommended levels of 1% EI. The EMR region was reported amongst the regions with the highest levels of TFA intake. The highest SFA intake was reported from Djibouti, Kuwait, Saudi-Arabia and Yemen, while the highest TFA intakes were reported from Egypt and Pakistan. If countries of the Eastern Mediterranean region receive immediate public health attention, that toll of NCD-related morbidity and mortality can be considerably decreased if evidence-based preventive interventions are implemented effectively. In this context, reductions in saturated fat and trans fat intakes have been highlighted as cost-effective strategies that may hamper the growth of the NCD epidemic.

Preprint ARTICLE | doi:10.20944/preprints202407.2477.v1

Sublethal Sodium Hypochlorite Exposure: Impact on Resistance-Nodulation-cell Division (RND) Efflux Pump Overexpression, and Cross-Resistance to Imipenem

Ji-Hyun Nam, Jung Sik Yoo

Subject: Public Health And Healthcare, Primary Health Care Keywords: cross-resistance; imipenem antibiotics; NaOCl disinfectant; resistance-nodulation-cell division (RND) efflux pump

Online: 31 July 2024 (08:32:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.2266.v1

Technological Interventions to Implement Prevention and Health Promotion in Cardiovascular Patients

Ayisha Zaka Bashir, Anji Yetman, Melissa Wehrmann

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Health promotion; cardiology; technology; cardiac rehabilitation; telemedicine and telehealth

Online: 30 August 2024 (15:36:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1897.v1

Research Progress on Starfish Outbreaks and Their Prevention and Utilization

Liang Qu, Yongxin Sun, Chong Zhao, Maurice R Elphick, Qingzhi Wang

Subject: Biology And Life Sciences, Aquatic Science Keywords: starfish; Asterias amurensis; outbreak; prevention; utilization

Online: 27 June 2024 (12:09:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0190.v1

Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges

Riccardo Foti, Gabriele Storti, Marco Palmesano, Maria Giovanna Scioli, Elena Fiorelli, Sonia Terriaca, Giulio Cervelli, Bong Sung Kim, Augusto Orlandi, Valerio Cervelli

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: adipose-derived stem cells; mesenchymal stem cells; ageing; senescence; stem cell therapy; senescence; diabetes; senolytic drugs

Online: 2 July 2024 (10:24:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0958.v1

Comparison of the HBSC Results of the Visegrad Countries with the Health Behavior of Young People with Disabilities Living in Hungary: A Cross-Sectional Study

Agota Barabas, Attila Csaba Nagy, Viktoria Pazmany, Anita Katalin Grestyak Molnarne, Nemeth Agnes, György Jona, Agnes Santha, Peter Takacs, Emil Toldy, Renata Javorne Erdei

Subject: Public Health And Healthcare, Other Keywords: health; health behavior; disability; Visegrad Group

Online: 18 March 2024 (09:10:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1703.v1

Distribution Characteristics and Genesis Mechanism of Ground Fissures in Three Northern Counties of the North China Plain

Chao Xue, Mingdong Zang, Zhongjian Zhang, Nengxiong Xu, Feiyong Wang, Cheng Hong, Guoqing Li, Fujiang Wang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Ground fissures; North China Plain; distribution characteristics; causative mechanism

Online: 25 June 2024 (00:31:48 CEST)

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The North China Plain is among the regions most afflicted by ground fissure disasters in China. Recent urbanization has accelerated ground fissure activity in the three counties of the northern North China Plain, posing significant threats to both the natural environment and socioeconomic sustainability. Despite the increased attention, a lack of comprehensive understanding persists due to delayed recognition and limited research. This study conducted field visits and geological surveys across 43 villages and 80 sites to elucidate the spatial distribution patterns of ground fissures in the aforementioned counties. By integrating these findings with regional geological data, we formulated a causative model to explain ground fissure formation. Our analysis reveals a concentration of ground fissures near the Niuxi and Rongxi faults, with the former exhibiting the most extensive distribution. The primary manifestations of ground fissures include linear cracks and patch-shaped collapse pits, predominantly oriented in east-west and north-south directions, indicating tensile failure with minimal vertical displacement. Various factors contribute to ground fissure development, including fault activity, ancient river channel distribution, bedrock undulations, rainfall, and ground settlement. Fault activity establishes a concealed fracture system in shallow geotechnical layers, laying the groundwork for ground fissure formation. Additionally, the distribution of ancient river channels and bedrock undulations modifies regional stress fields, further facilitating ground fissure emergence. Rainfall and differential ground settlement serve as triggering mechanisms, exposing ground fissures at the surface. This research offers novel insights into the causative mechanisms of ground fissures in the northern North China Plain, providing valuable scientific evidence for mitigating ground fissure disasters during the urbanization process in the region.

Preprint REVIEW | doi:10.20944/preprints202403.1614.v1

Molecular Circuits of Immune Sensing and Response to Oncolytic Virotherapy

Darshak K Bhatt, Toos Daemen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: molecular pathways; oncolytic virus; pattern recognition receptors; transcription factors

Online: 26 March 2024 (16:57:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1542.v1

Attitudes of Healthcare Professionals in an Autonomous Community in Spain towards Paediatric Influenza Vaccination

Jaime Jesús Pérez-Martín, Antonio Iofrío de Arce, Matilde Zornoza-Moreno

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Influenza vaccines; Healthcare professional; Attitude of Healthcare professional; intramuscular vaccine; Inhaled vaccine

Online: 24 April 2024 (07:26:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1724.v1

Data Loss Prevention Method Based on Multiprotocol Connectivity for IoT

Hamza Takrouni, Larbi Talbi, Youcef Fouzar

Subject: Engineering, Telecommunications Keywords: Internet of Things, Cloud Computing, Edge Computing, Big Data, IoT Communications Protocols

Online: 29 February 2024 (11:06:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1151.v1

Whole-Genome Sequencing Analysis of Antimicrobial Resistance, Virulence Factors, and Genetic Diversity of Salmonella Isolated from Wenzhou, China

Yafang Jin, Yi Li, Shaojie Huang, Chengji Hong, Xucong Feng, Huidi Cai, Yanmei Xia, Shengkai Li, Leyi Zhang, Yongliang Lou, Wanchun Guan

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Salmonella; antimicrobial resistance; pathogenicity islands; cgMLST; Whole genome sequencing

Online: 16 September 2024 (03:20:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1426.v1

Improving the Efficiency and Safety of Sentinel Stink Bug Eggs Using X-Rays

Evelyne Hougardy, Ronald P. Haff, Brian N. Hogg

Subject: Biology And Life Sciences, Insect Science Keywords: stink bug; egg parasitism; field monitoring; sentinel eggs; x-ray irradiation; egg sterilization

Online: 18 September 2024 (13:57:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0253.v1

Prevalence and Prevention of Clinical Injuries Among Undergraduate Dental Students: A Post-COVID-19 Study

Maria Antoniadou, Maria Chanioti, Asteropi Pantelaki, Antonios Parasiris, Evangelia Piperi, Christos Rahiotis

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: percutaneous injuries; dentists; dental students; COVID-19 pandemic; dental students’ stress; dental school environment

Online: 5 June 2024 (08:25:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0107.v1

Maximum Storm Tide Response to the Intensity of Typhoons and Bathymetric Changes along the East Coast of Taiwan

Wen-Cheng Liu, Wei-Bo Chen, Lee-Yaw Lin

Subject: Engineering, Control And Systems Engineering Keywords: maximum storm tide; two-dimensional tide-surge modeling system; east coast of Taiwan; intensity of typhoon; bathymetric rise

Online: 28 February 2017 (13:00:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1207.v1

How the Choice of the Starting Time of the Observation Day May Affect Daily Precipitation Amounts and Extremes: Problem Analysis and Adjustment Methods

Francesca Becherini, Claudio Stefanini, Antonio Della Valle, Francesco Rech, Fabio Zecchini, Dario Camuffo

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: daily precipitation; time of observation; time series; aggregation method; adjustment method; hourly dataset; daily extremes

Online: 22 February 2024 (01:19:32 CET)

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The study of precipitation amount at different time scales constitutes an important issue in climate research and risk assessment. When dealing with daily totals, a frequent but sometimes underestimated problem is at what time the observation day begins. The choice of different starting times may lead to incompatibility between stations and incorrect identification of extreme events. In this work, the problem of temporal misalignment between precipitation datasets characterized by different starting time of the observation day is analyzed. The most widely used adjustment methods (1day and uniform shift) and two methods based on reanalysis (NOAA and ERA5) are evaluated in terms of temporal alignment, precipitation statistics and percentile distributions. As test series, the precipitation amount collected from 9 a.m. local time (09 LT) on the previous day to 09 LT on the target day (9-9 datasets) of the Padua and nearby stations in the period 1993-2022 have been selected. Results show that the reanalysis-based methods, in particular ERA5, outperform the others in temporal alignment, regardless the station. But, for the periods in which reanalysis data are not available, “1day” method, which shifts the daily amount back one calendar day, and “unif” method, which distributes uniformly the daily total from a 2-day moving window surrounding the target date, can be considered valid alternatives. On the other side, concerning the precipitation statistics, the reanalysis-based methods are not the best option, as they increase the precipitation frequency and reduce the mean value over wet days, NOAA much more than ERA5. Nevertheless, the uniform method provides a larger deviation from the original daily series. The use of the series of a station nearby the target one, which is mandatory in case of missing data, gives similar or better results than applying any adjustment method to the 9-9 series. General conclusions can hardly be drawn as they depend on the method and station. For the Padua dataset, the analysis was repeated at monthly and seasonal resolution. In general, the adjustment series show the most relevant changes in the precipitation statistics in summer and less temporal alignment with the original series in summer and autumn, the two seasons mainly affected by heavy rains in Padua. Finally, the percentiles distribution, analyzed for all the methods and stations, indicates that any adjustment method underestimates the percentile values, except ERA5. Only Legnaro, the station most correlated with Padua, gives results like ERA5.

Preprint ARTICLE | doi:10.20944/preprints202104.0129.v1

Breaking the Cycle: Women’s Perceptions of the Causes of Violence and Crime in Informal Settlements in Nairobi, Kenya and their Strategies for Response and Prevention

Samantha Winter, Lena Moraa Obara, Nathan Jason Aguilar, Laura Johnson

Subject: Business, Economics And Management, Accounting And Taxation Keywords: violence; crime; informal settlements; women; Kenya

Online: 5 April 2021 (12:38:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0083.v1

The Joint Use of Multiple Satellite SAR Data and Geotechnical Models for the Study of the Shanghai Ocean-Reclaimed Lands

Antonio Pepe, Manuela Bonano, Qing Zhao, Tianliang Yang, Hanmei Wang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: deformation; interferometry; geotechnical models; non‐linear problem; synthetic aperture radar (SAR); time‐series

Online: 8 August 2016 (14:50:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1293.v1

Microbiological Diagnosis – an Important Tool for Prevention and Management of Peri-Implant Infective Diseases

Adrian Țandără, Cristian Funieru, Oana Slușanschi, Cristina Preoteasa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: peri-implant infective diseases; microbiota; antibiogram

Online: 18 September 2024 (04:51:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1352.v1

Strategies for Carbon Neutrality: Innovations in Construction Material Production and Usage

Adrian Ioana, Diana Cristina Labes (Craciun), Nicolae Constantin, Augustin Semenescu, Roxana Marina Solea (Iordachescu), Dumitru Viorel Deonise, Alexandra Istrate

Subject: Engineering, Civil Engineering Keywords: construction; materials; carbon; emission; strategy.

Online: 19 June 2024 (12:51:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0577.v1

Factors Associated With Complications of Snakebite Envenomation in Health Facilities in the Cascades Region of Burkina Faso, 2016 to 2021

Réné Kinda, Sidikiba Sidibe, Dramane Zongo, Tieba Millogo, Alexandre Delamou, Seni Kouanda

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Snakebite; Envenomation; Complications

Online: 11 June 2024 (08:48:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2535.v1

Mechanisms of Mammalian RNA Interference-Based Antiviral Strategies

Neelabh Datta

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: RNAi; antiviral response; interferon response; immunity

Online: 1 August 2024 (05:17:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1887.v1

Ammonia Emissions and Building-Related Mitigation Strategies in Dairy Barns: A Review

Serena Vitaliano, Provvidenza Rita D'Urso, Claudia Arcidiacono, Giovanni Cascone

Subject: Engineering, Other Keywords: livestock buildings; dairy cattle; gaseous emissions; emission rates; best available techniques

Online: 27 June 2024 (03:55:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints201608.0036.v1

Bioresponsive Hydrogels: Chemical Strategies and Perspectives in Tissue Engineering

Antonella Sgambato, Laura Cipolla, Laura Russo

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: hydrogels; tissue engineering; bioconjugation

Online: 4 August 2016 (11:00:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1802.v1

Optimizing Groundwater Exploration Strategies in Huarong, China with 2-Dimensional Resistivity Imaging

Osama Abdul Rahim, Chen Rujun, Liu Chunming, Ijaz Ahmed, Farid Ullah, Jawad Ahmad, Shah Fahad, Shahid Ali Shah, Hesham El-Kaliouby

Subject: Environmental And Earth Sciences, Other Keywords: 2D Electrical Resistivity Imaging; forward and inverse pole-dipole configuration; hydrogeological survey; groundwater exploration

Online: 26 June 2024 (03:02:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0999.v1

Assessing the Feasibility of Handheld Cameras to Increase Access to Teleretinal Diabetic Retinopathy Screenings in Safety-Net Clinics in Los Angeles

Gabrielle Green, Roxana Flores, Elvia Figueroa, Tony Kuo, Lauren Daskivich

Subject: Public Health And Healthcare, Primary Health Care Keywords: Teleretinal diabetic retinopathy screenings; handheld cameras; safety-net; diabetes; feasibility

Online: 12 September 2024 (16:01:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1679.v1

Adenomyosis: A Call for Awareness, Early Detection and Effective Treatment Strategies

Georgios Kolovos, Ioannis Dedes, Sara Imboden, Michel Mueller

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: adenomyosis; reproductive health; early detection; minimal invasive therapy

Online: 27 May 2024 (07:12:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1311.v1

Exosome-Like Systems: From Therapies to Vaccination for Cancer Treatment and Prevention—Exploring the State of the Art

Hamid Heydari Sheikhhossein, Francesca Iommelli, Natalia Di Pietro, Maria Cristina Curia, Adriano Piattelli, Rosanna Palumbo, Giovanni N Roviello, Viviana De Rosa

Subject: Biology And Life Sciences, Life Sciences Keywords: exosomes; cancer vaccines: immune system

Online: 19 April 2024 (08:09:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1588.v1

Cephalometric Evaluation of Children with Short Stature of Genetic Etiology. A Review

George Paltoglou, Nickolas Ziakas, George P. Chrousos, Christos Yapijakis

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: short stature; genetics; genetic syndromes; craniofacial morphology; cephalometric radiograph; growth hormone/insulin-like growth factor 1 axis; epiphyseal growth plate; cartilage extracellular matrix

Online: 24 May 2024 (11:17:53 CEST)

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Introduction: A plethora of biological molecules regulate chondrogenesis in the epiphyseal growth plate. Disruptions of quantity and function of these molecules can manifest clinically as stature abnormalities of various etiologies. Traditionally, the growth hormone/insulin-like growth factor 1 (IGF1) axis represents the etiological center of final stature attainment. Of note, little is known about the molecular events that dominate the growth of the craniofacial complex and its correlation with somatic stature. Aim: Given the paucity of the relevant data, this review discusses available information regarding potential applications of lateral cephalometric radiography as a potential clinical indicator of genetic short stature in children. Materials and Methods: A literature search was conducted in the PubMed electronic database using the key words: cephalometric analysis and short stature; cephalometric analysis and achondroplasia; cephalometric analysis and hypochondroplasia; cephalometric analysis and skeletal abnormalities; cephalometr* and SHOX; cephalometr* and CNP; cephalometr* and ACAN; cephalometr* and CNVs; cephalometr* and IHH; cephalometr* and FGFR3; cephalometr* and Noonan syndrome; cephalometr* and “Turner syndrome”; cephalometr* and achondroplasia. Results: In individuals with genetic syndromes causing short stature, linear growth of the craniofacial complex is confined, following the pattern of somatic short stature regardless of its etiology. The angular cephalometric measurements differ from the average height normal individuals and are suggestive of a posterior placement of the jaws and a vertical growth pattern of the face. Conclusion: The greater part of the existing literature regarding cephalometric measurements in short statured children with genetic syndromes provides qualitative data. Furthermore, cephalometric data for individuals affected with specific rare genetic conditions causing short stature, should be the focus of future studies. These quantitative data are required to potentially establish cut-off values to refer for genetic testing based on craniofacial phenotypes.

Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0464.v1

Evaluation of Psychosomatic, Respiratory, and Neurocognitive Health in COVID-19 Survivors 12 Months after ICU Discharge

Nicolas Germann, Daria Amozova, Kristina Göhl-Freyn, Tim Fischer, Manuel Frischknecht, Gian-Reto Kleger, Urs Pietsch, Miodrag Filipovic, Martin H. Brutsche, Thomas Frauenfelder, Christian R. Kahlert, Dagmar A. Schmid, Werner C. Albrich

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; Intensive Unit Care; ICU; Predictive Model; Psychosomatic Health

Online: 5 July 2024 (00:23:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1101.v1

Hydrogeochemical Characteristics of Earthquake-Related varied-temperature Springs along the Eastern Kunlun Fault Zone, China

Chao Lu, Xiaocheng Zhou, Jiyi Jiang, Jingchao Li, Jing Li, Jing Wu, Xiaoyi Zhu, Jiang Li, Gaoyuan Xing, Shihan Cui

Subject: Environmental And Earth Sciences, Other Keywords: varied-temperature water; hydrogeochemistry; isotopes; seismic precursor; Eastern Kunlun Fault

Online: 19 March 2024 (08:53:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0168.v1

Preparedness, Prevention, Investigation, and Response to the Emergence of Mpox in Khartoum, Sudan in 2022

Yousif Ali, Emmanuel Edwar Siddig, Mohammed Osman, Nouh Saad Mohamed, Ahmed Musa, Ayman Ahmed

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Mpox; Outbreak; Pandemic Preparedness and Response; global health emergency of international concern; epidemiology, Zoonoses, One Health; Global Health Security

Online: 4 June 2024 (10:43:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2221.v1

Human-Activity-Mediated Gene Flows Are Involved in the Establishment of Magnaporthe oryzae Population Structures: A Population Genomic Analysis

Guohua Duan, Yuchan Liu, Cheng Zheng, Kaihui Yu, Jiahui Xie, Baohua Wang, Huakun Zheng, Wei Tang, Jiandong Bao, Zonghua Wang, Meilian Chen

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Magnaporthe oryzae; population structure; genetic diversity; gene flow

Online: 30 August 2024 (08:36:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1887.v1

Research on Personalized Teaching Strategies Selection based on Deep Learning

Chun Wang, Jiexiao Chen, Ziyang Xie, Jianke Zou

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Personalized Teaching; Strategies Selection; Deep Learning; Individual Development

Online: 27 August 2024 (00:34:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1491.v1

Stress Perceptions, Somatization, and Coping Strategies among Dentistry and Nursing Students: A Comparative Study

Maria Antoniadou, Georgia Manta, Antonia Kanellopoulou, Theodora Kalogerakou, Alessandra Satta, Polyxeni Mangoulia

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: nursing students; dentistry students; stress somatization; coping strategies; gender differences; academic stress; stress management; psychological support; mentoring; coaching in healthcare

Online: 21 June 2024 (07:22:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0478.v1

Gastric Cancer Image Classification: a Comparative Analysis and Feature Fusion Strategies

Andrea Loddo, Marco Usai, Cecilia Di Ruberto

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Computational Pathology; Histopathological Imaging; Gastric Cancer; Convolutional Neural Networks; Machine Learning; Deep Learning; Feature Extraction; Feature Combination

Online: 6 July 2024 (03:16:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1300.v1

Enhancing Cancer Therapy through Polymeric Nano-particles: Targeted Drug Delivery Strategies

Desta Tesfay Mezgebo, Yohannes Reda Tesfay, Guruduta Pattnaik

Subject: Medicine And Pharmacology, Pharmacy Keywords: Polymeric Nanoparticle; Drug Delivery; Cancer; Ligands; Antibodies

Online: 22 February 2024 (12:20:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0641.v1

Plant-Derived Bioactive Compounds: Exploring Neuroprotective, Metabolic, and Hepatoprotective Effects for Health Promotion and Disease Prevention

Rosa Direito, Sandra Maria Barbalho, Bruno Sepodes, Maria Eduardo Figueira

Subject: Biology And Life Sciences, Food Science And Technology Keywords: by-products; berries; artichoke; grapevine; gooseberry; polygonoideae plants; olive oil; inflammation

Online: 12 February 2024 (07:41:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.1335.v1

Innovative Approaches and Emerging Paradigms: A Literature Review on Novel Therapeutic Strategies in Organ Transplantation

Imran Rangraze, Shehla Khan, Malay Jhancy, Rajani Dube, B K Manjunatha Goud, Subhranshu Kar, Adil Farooq Wali

Subject: Medicine And Pharmacology, Transplantation Keywords: transplantation; donor; recipient; patient survival; graft; Precision medicine; Gene editing

Online: 23 April 2024 (10:48:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0325.v1

Navigating the Path to Management: Insights into Sport Manager Selection and Diversity Strategies in Romania

Valentina Stefanica, Marko Joksimović, Halil İbrahim Ceylan, Raul- Ioan Muntean

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: affirmative action; recruitment strategies; decision making; board selection; organizational culture

Online: 7 May 2024 (17:15:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0767.v1

Agricultural and Technology-Based Strategies to Improve Water Use Efficiency in Arid and Semiarid Areas

Saif F. Alharbi, Mohammed Aldakil, Abrar Felemban, Ahmed Abdelrahim

Subject: Environmental And Earth Sciences, Soil Science Keywords: Water use efficiency; Agricultural water use; crop production; Agronomic practices

Online: 13 May 2024 (08:12:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1104.v1

Health Benefits of White Mulberry, Sea–Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn — Prevention and Treatment of Cardiovascular Disease

Aleksandra Witkowska, Anna Gryn–Rynko, Patrycja Syrkiewicz, Klaudia Kitala–Tańska, Michał S Majewski

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: white mulberry; sea– buckthorn; garlic; lily of the valley; motherwort; hawthorn

Online: 22 March 2024 (07:33:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1222.v1

Disentangling the Physiological Responses of Sweet Orange Citrus Trees to Optimize the Design of Deficit Irrigation Strategies

Alfredo Emilio Rubio-Casal, Victor Hugo Durán-Zuazo, Iván Francisco García-Tejero

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Chlorophyll fluorescence; thermography; crop physiology; drought stress

Online: 18 April 2024 (13:38:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0882.v1

Sexual Rehabilitation Strategies and Outcomes among Cervical Cancer Survivors A

Samson Peter Mvandal, Mashaka Sehemu

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: cervical cancer; cervical cancer survivors; rehabilitation; sexual dysfunction; sexual rehabilitation
trategies

Online: 13 May 2024 (16:23:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0595.v1

Research on Old Building Renovation Strategies by using Green Building Technologies

Zhang Feng, Minyue Ge, Qian Meng, Yixue Chen

Subject: Engineering, Architecture, Building And Construction Keywords: Building renovation; Green building strategies; Energy-efficient systems; Sustainable utilization

Online: 9 September 2024 (09:14:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1573.v1

Statistical Optimization Strategies for the Extraction Process Parameters of Bioactive Molecules from Seafood Byproducts

Zenebe Tadesse Tsegay, Sofia Agriopoulou, Moufida Chaari, Slim Smaoui, Thedoros Varzakas

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Optimization; extraction; parameters; bioactive molecules; seafoods byproducts; green extraction

Online: 26 March 2024 (11:23:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.0734.v1

Advances in Corrosion of High-Temperature Materials: Interfacial Migration and Alloy Design Strategies

Aditya Narayan Singh, S. K. Swain, Abhishek Meena, Mobinul Islam, Kyung-Wan Nam

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: Quantum electron transport (QET); degradation; hot-corrosion; catalysis; Gibbs free-energy; selective oxidation.

Online: 10 July 2024 (12:31:33 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.0243.v1

Bridging the Gap between Academia and Society: Research, Training and Strategies Alliances for Sustainable Development

Pilar Posadas de Julián, Carmen Verdejo Lucas, Belén De Rueda Villén, M. del Mar Haro-Soler, José Gijón Puerta, Elvira Cámara Aguilera, Mercedes García de Quesada

Subject: Social Sciences, Education Keywords: curriculum innovation in Higher Education; inner development goals; education for sustainable development; university governance; LifeComp; GreenComp; employability; university-industry strategic partnerships

Online: 5 March 2024 (06:06:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0063.v1

Customer Churn - Prevention Model

Julian Eduardo Grijalba Facundo

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Churn 1; customer churn; customer segmentation; churn prevention; predictive churn model; recommendation system engine.

Online: 2 June 2021 (10:03:02 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.1562.v1

Clip Closure and PuraStat for Prevention of Clinically Significant Delayed Bleeding after Colorectal Endoscopic Submucosal Dissection: A Prospective, Observational Study

Mihai Ciocirlan, Dana Bilous, Andrei Gila, Daniel Corneliu Leucuta, Daniela Elena Mihaila, Adrian Tulin, Anca Gheorghiu, Elena Tianu, Catalina Vladut

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: endoscopic submucosal dissection; clip closure; PuraStat; muscle retracting sign; colorectal mixed neuroendocrine carcinoma

Online: 24 April 2024 (09:58:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints201611.0067.v1

Review on Usage of Vancomycin in Livestock and Humans: Maintaining its Efficacy, Prevention of Resistance and Alternative Therapy

P. N. K. WIJESEKARA, W. W. Kumbukgolla, Jayaweera Arachchige Asela Sampath Jayaweera, D. S. Rawat

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: vancomycin; broad view; veterinary use at a glance; rational use; alternatives

Online: 12 November 2016 (11:09:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1259.v1

An Overlooked Group of Citizen Scientists in NIS Information: Shell Collectors and Their Contribution to Molluscan NIS Diversity

Argyro Zenetos, Cristiane DELONGUEVILLE, Roland SCAILLET

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Alien species; Mediterranean Sea; mollusca; citizen science; amateur malacologists

Online: 18 April 2024 (12:30:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1369.v1

Effects of Bioactive Compounds in the Foods for Prevention of Metabolic Syndrome

Lu Huang, Ram B Singh, MA Manal Smail, Ghizal Fatima

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Foods and function; health; functional foods; healthy diet; diseases; micronutrient; nutraceuticals; flavonoids

Online: 20 August 2024 (03:38:26 CEST)

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It seems that natural compounds with bioactivity are the food constituents, present in the diets, that may provide protective effects on health due to their biochemical effects. The main benefits appear to be decline in oxidative stress and inflammation that are crucial in the pathogenesis of obesity, diabetes and metabolic syndrome. Apart from anti-inflammatory activity, these molecules also possess antifungal, and anti-infective preventative effects. Further evidence indicate that these bioactive molecules are the constituents, which are known to increase function of the foods. This review aims to emphasize that plant based diet is rich in phytochemicals such as antioxidants, vitamins, minerals, polyphenolics and flavonoids, amino acids and fatty acids, that are able to cause benefits via these compounds. These bioactive molecules can target mechanisms of oxidative stress and inflammation that are crucial in the management of metabolic syndrome. These antioxidant compounds appear to be essential component of plant based diets and are crucial for healthiness. Most investigators have proposed that bioactive compounds act as nutraceuticals which are able to regulate certain patho-physiological mechanisms responsible for metabolic diseases. The bioactive compoundspresent in the plant based diets are primary and secondary metabolites of nutritive and non-nutritive natural components generating health benefits by preventing or managing chronic disease or its symptoms. The bioactive compounds are known for their beneficial effects to health. Despite their small quantity in the diets, these bioactive compounds may trigger certain mechanisms that may cause alteration with improvement in health. It seems that most of the bioactive compounds co-existing in the plant-based diets, may be extremely healthful. However, if they are taken in excess, they can cause toxic effects. There is an urgent need to evaluate each bioactive compound to establish a beneficial quantity and a threshold of toxicity, while treating metabolic syndrome.

Preprint REVIEW | doi:10.20944/preprints202404.1414.v1

The Veterinarian’s Role in Biocontainment Research Animal Facilities and Prevention of Spread of Pathogens in Africa

John Kudakwashe Chipangura, Abdussamad M. Abdussamad, David I. Lewis

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Veterinarian; Biocontainment research animal facility; Epicentre; Pathogens; Contamination

Online: 22 April 2024 (14:02:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0906.v1

Age and Density of Mated Females Affect Dispersal Strategies in a Spider Mite

Peng Zhou, Xiong Z. He, Chen Chen, Qiao Wang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: age-specific reproduction; population density; resource competition; dispersal probability; dispersal distance

Online: 15 April 2024 (05:46:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0967.v1

Sustainable Sludge Management in China: Quantifying GHG Emissions and Exploring Its Reduction Strategies

Dongming Hu, Peng Jiang, Yipei Chen, Fuyao Gao, Shuai Liu

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: Greenhouse gas emission; life cycle assessment; sludge management; sustainability.

Online: 14 June 2024 (10:48:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0085.v1

Effect of High Sucrose Diet on the Occurrence and Progression of Diabetic Retinopathy and Dietary Modification Strategies

Chen Yang, Yifei Yu, Jianhong An

Subject: Medicine And Pharmacology, Ophthalmology Keywords: high-sucrose diet; diabetic retinopathy; hyperglycaemia; dietary modification strategies

Online: 1 April 2024 (14:41:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0894.v1

The Association between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank

Qiuge Zhang, Xueting Qi, Zhaoguo Wang, Dongfeng Zhang, Tong Wang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: sleep disorder; diet; vitamin c; UK Biobank

Online: 11 September 2024 (15:20:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1874.v1

BIM-Based Strategies for the Revitalization and Automated Management of Buildings: A Case Study

Stefano Cascone, Giuliana Parisi, Rosa Caponetto

Subject: Engineering, Architecture, Building And Construction Keywords: BIM; Generative Design; Building Management; Cultural Heritage; Digital Twin; IoT; Revitalization

Online: 26 June 2024 (12:43:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0420.v1

Neurotrauma Prevention Review: Improving Helmet Design and Implementation

Michael Goutnik, Joel Goeckeritz, Zackary Sabetta, Tala Curry, Matthew Willman, Jonathan Willman, Theresa Currier Thomas, Brandon Lucke-Wold

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: helmet; military; sport; innovation; secondary injury

Online: 27 July 2022 (10:19:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0462.v1

When Polyphenols Meet Sphingolipids: Cancer Prevention and Therapy

Michele Dei Cas, Riccardo Ghidoni

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: sphingolipids; ceramide; flavonoids; resveratrol; genistein; curcumin, nutrients; nutraceuticals; chemotherapeutics

Online: 31 May 2018 (08:26:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0187.v1

A Review of the Literature to Outline How the Vestibular Efferent System Correlates the Complexity of Routine Balance Maintenance with Management of Emergency Fall Prevention Strategies

Neil S. Longridge, Arthur I. Mallinson

Subject: Medicine And Pharmacology, Otolaryngology Keywords: otoliths; utricle; saccule; hair cells; vestibular efferents ambulation; feedforward; evolution; vestibular morphology

Online: 3 May 2024 (10:24:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1011.v1

Therapeutic Strategies for RB1-Deficient Cancers: Intersecting Gene Regulation and Targeted Therapy

Mo-Fan Huang, Yuan-Xin Wang, Yu-Ting Chou, Dung-Fang Lee

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: retinoblastoma; RB1; E2F; Targeted Therapy; Therapeutic Vulnerabilities; Spliceosome; Cell Cycle; Epigenetic Regulators; Ubiquitin-Proteasome Pathway

Online: 18 March 2024 (10:29:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0782.v1

Designing Retirement Strategies for Coal-Fired Power Plants to Mitigate Air Pollution and Health Impacts

Carla Campos, Emily L. Pakhtigian, Wei Peng, Joel R. Landry, Hannah Wiseman, An T. Pham

Subject: Environmental And Earth Sciences, Pollution Keywords: coal retirement; air quality; human health; environmental justice

Online: 11 April 2024 (07:43:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1145.v1

Manufacturing Strategies for a Family of Integrated Photovoltaic-Fuel Cell Systems

Chukwuma Ogbonnaya, Grace Hegarthy

Subject: Engineering, Energy And Fuel Technology Keywords: Renewable energy technologies; Supply chain management; Lean and agile manufacturing; Modularisation; IPVFC systems; Decarbonisation; Hydrogen; Distributed generation; Manufacturing management; Domain-based thinking; Model-based systems engineering

Online: 15 August 2024 (14:32:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0463.v1

Strategies and Actions’ Definition for the New Territorial Government Plan of Voghera, Italy: Towards a Healthier City

Roberto De Lotto, Caterina Pietra, Matilde Sessi, Elisabetta Venco

Subject: Engineering, Architecture, Building And Construction Keywords: strategic planning; practical planning actions; healthy city; planning process

Online: 8 May 2024 (10:34:33 CEST)

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