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Preprint ARTICLE | doi:10.20944/preprints202403.0706.v1

Innate and Adaptive Regulation of Cognition

Rodrick Wallace

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: n/a; cognition; control thory; Fisher Zero phase transition; hierarchy; information theory; pathology; statistical models

Online: 12 March 2024 (13:48:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1265.v1

The Influence of Gender on the Psychiatric Comorbidity of Treated Danish Patients With and Without Alcoholism

Elizabeth C Penick, Waheeda A. Hossain, Wendy Madarasz, Ann M Manzardo, Joachim Knop, Erik L Mortensen, William F Gabrielli

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Alcohol use disorder; Gender; Psychiatric comorbidity

Online: 19 April 2024 (09:56:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1207.v1

Mechanical Properties of an Extremely Tough 1.5 mol% Yttria Stabilized Zirconia Material

Frank Kern, Bettina Osswald

Subject: Chemistry And Materials Science, Ceramics And Composites Keywords: zirconia; mechanical properties; transformation toughening; microstructure

Online: 15 July 2024 (14:37:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1607.v1

Properties of a Pressureless Sintered 2Y-TZP Material Combining High Strength and Toughness

Frank Kern, Bettina Osswald

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: zirconia; high toughness; microstructure; phase composition

Online: 24 May 2024 (08:38:08 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202001.0210.v1

The Autism Palette: Combinations of Impairments Explain the Heterogeneity in ASD

Ábel Fóthi, András Lőrincz, Latha Soorya

Subject: Social Sciences, Behavior Sciences Keywords: neuropsychiatric disorder; cognition; social behavior; dimensionality, reward; heterogeneity; autoencoder; components; genetic causes

Online: 19 January 2020 (04:53:42 CET)

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Autism spectrum disorder (ASD) is a heterogeneous neuropsychiatric problem with a few core symptoms: weaknesses in social behavior, verbal impairments, repetitive behavior and restricted interests. Beyond the core symptoms, autism has strong association with other disorders such as intellectual disability, epilepsy, schizophrenia among many others. This paper outlines a theory of ASD with capacity to connect heterogeneous ‘core’ symptoms, medical and psychiatric comorbidities as well as other etiological theories of autism in a unifying cognitive framework rooted in neuroscience and genetics. Cognition is embedded into an ever-developing structure modified by experiences, including the outcomes of environment influencing behaviors. We introduce the hypothesis that autism is caused by deficits in component-based cognition and the internal learning reinforcing machinery. Specifically, we outline our Cartesian Factor forming autoencoder like model that supports cognition by breaking combinatorial explosion and discuss the cognitive and neural processes behind our model. The high dimensionality of sensory information poses serious problems, since the brain can handle only 7±2 relevant variables at a time making processes, such as the extraction and encoding of the relevant variables and their efficient manipulation critical. These processes are influenced by previous experiences and the internal reward system. In addition, large delays of distributed information processing should be counteracted by learned predictive models to synchronize sensory, proprioceptive, and cognitive signals and have timely and accurate model-based actions. Impairments in any of these aspects may disrupt learning and execution. Combinations of small impairments may allow the solving of low complexity tasks but may become visible if learned variables and the related metric are improper and imprecise, respectively, especially if their number is large. We claim that social interactions are amongst the most challenging cognitive tasks in terms of the number of variables involved. In turn, they are highly susceptible to combinations of small impairments. We consider impairments as the basic colors of autism, whereas the combinations of diverse impairments make the palette of autism. In turn, social processes can be spoiled in many ways and can lead to diverse comorbidities.

Preprint ARTICLE | doi:10.20944/preprints202405.1570.v1

Non-invasive Brain Stimulation Enhance the Physical Exercise Effect Against the Cognition Impairments and Dementia Symptoms in Alzheimer’s Disease: A Experimental Controlled Trial

Vernon Furtado-da-Silva, Célio José Borges, Ivete de Aquino Freire, Angeliete Garcês Militão, Mário Antônio de Moraes Vieira, Domingos Edno Castro Ribeiro, Dora Flora de Castro Ribeiro, João Rafael Valentim-Silva

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Short-term memory; Electroencephalography; Executive Function; Alzheimer’s disease; Brain Ageing; Working Memory

Online: 24 May 2024 (09:38:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1356.v1

Development of Chitosan-Based Films Incorporated with Chestnut Flower Essential Oil Possessed Good Anti-ultraviolet Radiation and Antibacterial Effects for Banana Storage

Yanfei Liu, Jingyuan Zhanag, Fei Peng, Kui Niu, Wenlong Hou, Bin Du, Yuedong Yang

Subject: Chemistry And Materials Science, Biomaterials Keywords: chestnut flower essential oil; composite film; chitosan; antibacterial activity; fruit packaging applications

Online: 22 March 2024 (06:24:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0607.v1

Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders its Relationship with the Body Mass Index

David Ruiz-Ramos, José Jaime Martínez-Magaña, Ana Rosa García, Isela Esther Juarez-Rojop, Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Emmanuel Sarmiento, María Lilia López-Narvaez, Nicolini Sanchez, Alma Delia Genis-Mendoza

Subject: Physical Sciences, Acoustics Keywords: Psychiatric comorbidity; Mexican population; Eating disorders

Online: 26 February 2021 (11:03:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0301.v1

Resilience, Anger, and Insomnia in Nurses after the End of the Pandemic Crisis

Argyro Pachi, Aspasia Panagiotou, Nikolaos Soultanis, Maria Ivanidou, Maria Manta, Christos Sikaras, Ioannis Ilias, Athanasios Tselebis

Subject: Social Sciences, Psychology Keywords: insomnia; anger; resilience; post-pandemic; nursing workforce

Online: 4 September 2024 (12:09:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0363.v1

The Impact of Applied Behavior Analysis on Autism in Diverse Cultural Contexts: A Non-Western Perspective

Priya Prakash, Priyal Khurana, Yashika Sharma, Nihit Gupta, Mayank Gupta

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ABA; Autism; Asia; Children; Behavioural intervention

Online: 4 September 2024 (14:51:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2050.v1

Refractive Surgery to Correct Visual Impairments in 267 Children with Autism Spectrum and Related Neuro-developmental Disorders: Improvements in Vision and Behavior

Margaret Reynolds, Nicholas Faron, James Hoekel, Lawrence Tychsen

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Autism spectrum; neurodevelopmental disorder; refractive surgery; myopia; hyperopia

Online: 31 July 2023 (11:29:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0024.v1

Normative Data for the D-KEFS Color-Word Interference and Trail Making Tests Adapted in Greek Adult Population 20–49 Years Old

Marianna Tsatali, Fotini Surdu, Andromachi Konstantinou, Despina Moraitou

Subject: Social Sciences, Psychology Keywords: D-KEFS; Color-Word Interference; executive functions; normative data; Trail Making Test

Online: 2 September 2024 (08:44:58 CEST)

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Background: This study was designed to adapt the Delis-Kaplan Executive System (D-KEFS) version of the Color-Word Interference (CWIT) and Trail making Tests (TMT) in Greek adult population from 20 to 49 years old, since it is of research as well as clinical importance to detect executive functions’ impairment in young adults with neurological or/and psychiatric conditions. Aims: Norms for the Greek adult population have been calculated to be available for neuropsychologists and health professionals who work in relevant settings. Methods: The study sample consisted of 101 healthy adults (41% male and 60% female), aged 20 to 49 years (M=32.16, SD=11.57) with education from 12 to 19 years of schooling (M=14.51, SD= .89). Pearson correlation test as well as chi square test were conducted to examine potential associations between gender, age, education, and participants’ performance. Afterwards, we calculated normative data using raw scores and transformed them to percentile scores. Finally, Greek norms were compared to the original raw scores, which were transformed in scaled scores by Delis et al. (2001). Results: The findings showed that age was the only variable which affected CWIT, whereas level of education as well as age were predictive factors for most TMT conditions, except for the visual scanning test (Condition 1). Gender did not affect both tests. Finally, D-KEFS norms for CWIT and TMT are available for Greek adult population to help clinicians detect executive functions’ deficits and therefore adjust tailored therapeutic strategies. Additionally, it is of great importance to use these tests for research purposes. Conclusion: Given that executive functions are assumed as high- level skills, which are highly related to everyday functionality, adapted tests contribute not only to assess the progression of any existing neurological as well as psychiatric disorders, but they can also be used to evaluate patients’ ability to live independently, as well as their access to work.

Preprint ARTICLE | doi:10.20944/preprints202408.2144.v1

Effects of Electroless Deposition Conditions on the Hydrogen Generation Kinetics of Co-Fe-P Catalysts via Hydrolysis of Ammonia Borane Solution

SeKwon Oh

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Cobalt-iron-phosphorus; Hydrogen evolution; Ammonia borane; Catalyst

Online: 29 August 2024 (10:44:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0803.v1

A follow up on the continuum theory of eco-anxiety: Analysis of the Climate Change Anxiety Scale using Item Response Theory

Taha Hannachi, Sonya Yakimova, Alain Somat

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: eco-anxiety; item response theory; continuum; Climate Change Anxiety Scale

Online: 10 July 2024 (12:03:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0604.v1

Wolfram Syndrome 1: A Neuropsychiatric Perspective on a Rare Disease

Valerio Caruso, Accursio Raia, Luciana Rigoli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Wolfram syndrome 1; WFS1 gene; neuropsichiatric disorders; new findings in Wolfram syndrome 1.

Online: 8 July 2024 (10:01:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0659.v1

Directional Vibro-Tactile Hazard Warnings for Drivers with Vision Impairments

Jing Xu, Felix M. Kölsch, Georg N. Dyszak, Christian Lehsing, Alex R. Bowers

Subject: Engineering, Transportation Science And Technology Keywords: driving safety; vision impairment; advanced driver assistance systems; hemianopia; central vision loss

Online: 11 March 2024 (18:14:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.2224.v1

Unveiling the Potential of Phytocannabinoids: Exploring Marijuana's Lesser-Known Constituents for Neurological Disorders

Balapal S Basavarajappa, Shivakumar Subbanna

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Endocannabinoids; Neurodegenerative disorders; Alcohol use disorders; substance use disorders; Psychiatric disorders; Epilepsy; Cannabinoid receptors; Alzheimer's disease; Parkinson's disease; Huntington's disease

Online: 27 September 2024 (13:40:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0981.v1

Epigenetic Alterations of Cognition Functions in Parkinson's Disease

Fatemeh Hasani, Payam Ahmadi, Mahdi Masrour, Sina Khamaki, Rahem Rahmati, Andrei Surguchov

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: alpha-synuclein; cognition; epigenetics; Parkinson’ s disease; Tau

Online: 14 June 2024 (08:39:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0347.v1

Navigating Uncertainty: A Tripartite Creative Knowledge Exchange Among Artists, Researchers, Carers and People with Lived Experience of Dementia, A co‐Created Space for Living Uncertainty

Mar Estarellas Garcia, Tatiana A Giovannucci, Lucy Steggals

Subject: Arts And Humanities, Other Keywords: uncertainty; participatory co‐creation; dementia; lived experience

Online: 4 September 2024 (09:25:39 CEST)

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In a world filled with uncertainties, Ebb&Flow emerged as a story of convergence, intertwining dementia research, caregiving, and artistic exploration into a tripartite creative knowledge exchange. This study delves into the complexities of uncertainty in dementia care and research through a collaborative project involving artists, researchers, carers, and individuals with lived experience of dementia. Initiated by the Trellis:Arbor program, Ebb&Flow sought to co-created a human space addressing the multifaceted nature of uncertainty. The sea, with its unpredictable nature, served as a guiding metaphor for the project, reflecting the unpredictability of dementia and life. Over three months, through paintings, writings, and digital mediums, participants documented the changing emotions, challenges, and discoveries they encountered daily. The project fostered an environment where uncertainties were openly discussed, building supportive and resilient communities through participatory co-creation and methodological exchange. Key activities included a digital logbook, allowing participants to document and share their experiences of uncertainty, and the creation of the Ebb&Flow card deck—a compilation of personal stories and insights that serve as a legacy of shared experiences. Each card facilitated dialogue, understanding, and connection, bridging gaps between those affected by dementia and the broader community. The project culminated in a final exhibition and sharing event, where participants, researchers, and the public celebrated the journey's outcomes through stories and artworks. Throughout this journey, we observed that embracing uncertainty and fostering empathy through creative collaboration profoundly impacted participants, enhancing empathy and resilience. This project underscores the transformative potential of integrating artistic practices with scientific research to address the emotional and psychological burdens of dementia and research environments. Ebb&Flow demonstrates that even in the face of the unknown, a united community can find strength, solace, and understanding, highlighting the power and beauty of unity in exploring and expressing the multifaceted experiences of dementia and life.

Preprint ARTICLE | doi:10.20944/preprints202403.0768.v1

Towards Cognition-Aligned Visual Language Models via Zero-Shot Instance Retrieval

Teng Ma, Daniel Organisciak, Wenbao Ma, Yang Long

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Large Visual Language Models; Zero-Shot Instance Retrieval; Cognition-Alignment

Online: 13 March 2024 (07:29:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1305.v1

Comorbidity Burden among Adults with Symptomatic COVID-19 Illness: A Cross-Sectional Study

Mini M. Jose, Juan Feng, Bushra Manakkat, Hoang Nguyen, Josie Tombrella, Patricia Savard, Hanaa S. Sallam, Hani Serag

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19 positive adults; Charlson Comorbidity Index; Comorbidity burden and COVID-19; Depression and COVID-19; Comorbidities and COVID-19; Social determinants of COVID-19

Online: 19 August 2024 (10:05:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1125.v1

Predictive Analysis of Osteoarthritis and Chronic Pancreatitis Comorbidity: Complications and Risk Factors

Iryna Halabitska, Liliia Babinets, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: osteoarthritis; chronic pancreatitis; comorbidity; complications; risk factors; predictors.; pancreatitis

Online: 15 July 2024 (10:26:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0018.v1

Investigating the Impact of Topology and Physical Impairments on the Capacity of an Optical Backbone Network

Alexandre Freitas, João Pires

Subject: Engineering, Telecommunications Keywords: network capacity; fiber assignment; random networks; optical networks; optical communications

Online: 1 March 2024 (05:40:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1101.v1

Interface Design For Autism In An Ever-Updating World

Lewis D. Sawyer, Ramaswamy Palaniappan

Subject: Computer Science And Mathematics, Computer Science Keywords: Accessibility; ASD; Autism; Change Impact; HCI; Human Factors; Software Updates

Online: 17 June 2024 (08:33:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1070.v1

Simulation and Testing of Grapevine Branch Crushing and Collection Components

Lei He, Zhimin Wang, Long Song, Pengyu Bao, Silin Cao

Subject: Engineering, Mechanical Engineering Keywords: grapevine branches; crushing collection; simulation and test

Online: 14 July 2024 (05:25:17 CEST)

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Using numerical simulation method, combined with the pre-branch material characteristics of the measurement results, based on the LS-DYNA software to simulate the branch crushing process, the analysis found that not only the existence of the cutter cutting in the branch destruction process, there is also the cutting of the opposing surface of the bending fracture, with the increase in the speed of the knife rollers, the cutter cutting resistance increases, the cutting resistance reaches 2690 N when the cutter at 2500 r/min, the cutter cutting resistance is the smallest in the cutting simulation at the blade angle of 55°, the blade angle is more suitable for the cutting of the branch. In the cutting simulation under different cutting edge angles, the cutting resistance of the tool is the smallest when the edge angle is 55°, which is 1860 N. This edge angle is more suitable for branch crushing and cutting. Using Fluent software to analyse the airflow characteristics of the crushing device, it was found that with the increase of the knife roller speed, the inlet flow and negative pressure of the crushing chamber are increasing, the speed of 2500 r/min, the inlet flow and negative pressure were 1.92 kg/s and 37.16 Pa, which will be conducive to the feeding of branches, but the speed is too high and it will also lead to the enhancement of the vortex of part of the area in the crushing device, which will affect the feeding of branches and the throwing of the crushed material. affect the feeding of branches and the throwing out of crushed materials, and finally determined the speed range of the crushing knife roller is 1800 ~ 2220 r/min. Based on ANSYS/Model module modal analysis of the crushing knife roller, the knife roller of the first six orders of the intrinsic frequency and vibration pattern, crushing knife roller of the lowest order of the modal intrinsic frequency of 137.42 Hz, much larger than the crushing knife roller operating frequency of 37 Hz, the machine will not resonate during operation.

Preprint REVIEW | doi:10.20944/preprints202312.0348.v2

Functional Myelin in Cognition and Neurodevelopmental Disorders

Hasni Khelfaoui, Cristobal Ibaceta-Gonzalez, Maria Cecilia Angulo

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: myelin; cognition; oligodendrocytes; OPCs; development; schizophrenia; autism spectrum disorder; brain oscillations

Online: 12 December 2023 (10:53:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1435.v1

Unveiling Hidden Risks: Prenatal and Demographic Insights into Autism Spectrum Disorder

Aikaterini Sousamli, Elena Dragioti, Dimitra Metallinou, Aikaterini Lykeridou, Panagiota Dourou, Chrysoula Rozalia Athanasiadou, Dimitrios Anagnostopoulos, Antigoni Sarantaki

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: autistic spectrum disorders; functioning; prenatal risk factors; maternal age; age of diagnosis; vaginal bleeding; prenatal infections; family income; birth order; family history

Online: 20 August 2024 (13:46:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0994.v1

The Curious Role of PAI‐1 in Severe OSA

Tea Friščić, Edvard Galić, Domagoj Vidović, Petrana Brečić, Igor Alfirević

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: plasminogen activator inhibitor-1; obstructive sleep apnea; continuous positive airway pressure; atherogenesis; fibrinolytic capacity

Online: 16 April 2024 (07:41:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0811.v1

Evaluation of Combining Plasma COX-2/PGE2 Ratio and Anti-nucleosome Autoantibodies as Possible Biomarkers for Clinically Predicting Autism Spectrum Disorders

Afaf El-Ansary, Hanan A. Alfawaz, Abir Ben Bacha, Laila Y. Alayadhi

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Autism, Auto-immunity; Anti-nucleosome autoantibodies; Cyclooxygenase-2; Prosta-glandin; Wnt signaling; Glutamate excitotoxicity.

Online: 10 July 2024 (10:14:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1128.v1

Estimation Model for Maize Multi-components Based on Hyperspectral Data

Hang Xue, Xiping Xu, Xiang Meng

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Hyperspectral imaging; Maize; Content detection; Non-destructive; LSSVM

Online: 15 August 2024 (16:33:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints201609.0022.v1

Art of Music, as Harmony of the Spheres and Autism Spectrum Disorder

Bharathi Geetha, Thangaraj Sugunadevi, Babu Srija, Nagarajan Laleethambika, Vellingiri Balachandar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Pervasive developmental disorder; Autism spectrum disorder (ASD); brain network; Theory of Mind (ToM); Music Therapy (MT); therapeutic effect

Online: 6 September 2016 (11:53:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2028.v1

The Molecular Comorbidity Network of Periodontal Disease

Mireya Martinez-Garcia, Enrique Hernandez-Lemus

Subject: Biology And Life Sciences, Life Sciences Keywords: Periodontal disease; Comorbidities; Molecular mechanisms of systemic diseases; Genetic associations; Biological databases; Inflammatory pathways

Online: 25 July 2024 (11:47:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0065.v1

Embodying Cognition in Cognitive Behavioral Therapy

Tania Pietrzak, Christina Lohr, Beverly Jahn, Gernot Hauke

Subject: Social Sciences, Psychology Keywords: embodiment; CBT; interpersonal synchrony; therapeutic alliance; emotional regulation; emotional field; emotional mastery

Online: 15 September 2017 (11:37:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0212.v1

Dietary Patterns Correlate with Transition Readiness of Adolescents with Autism: A Pilot Study

Lilian de Jonge, Blessing Seidu

Subject: Public Health And Healthcare, Other Keywords: Adolescents with autism; Comorbidities in autism; Dietary quality of adolescents with autism; Transition to adulthood for people with autism; Cross-sectional study

Online: 4 September 2024 (04:34:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0307.v1

Association between the Mother's Social Cognition and the Child's Social Functioning in Kindergarten: The Mediating Role of the Child's Social Cognition

Yair Ziv, Reout Arbel

Subject: Social Sciences, Psychology Keywords: social cognition; social information processing; mother-child relationships; parenting style; kindergarten; social functioning

Online: 26 November 2019 (04:11:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0306.v1

Vision impairments in young adults with Down syndrome

Yolanda Martin-Perez, Guadalupe Gonalez-Montero, Angel Luis Gutierrez-Hernandez, Vanesa Blázquez-Sánchez, Celia Sánchez-Ramos

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: aging; Down syndrome; quality of life; refractive error; visual impairments

Online: 3 August 2023 (10:27:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1999.v1

Relationship between Semantic Memory and Social Cognition in Schizophrenia

Javier Pérez-Flores, Antonieta Nieto, Ofelia Delgado

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; Semantic Memory; Social Cognition

Online: 30 May 2024 (08:14:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1048.v1

Computerized Cognitive Training in the Older Workforce: Effects on Cognition, Life Satisfaction, and Productivity

Zdenka Milič Kavčič, Voyko Kavcic, Bruno Giordani, Uros Marusic

Subject: Biology And Life Sciences, Aging Keywords: older employees; 50+; computerized cognitive training (CCT); productivity; well-being

Online: 17 June 2024 (07:57:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0395.v1

Quantum-Like Cognition and Rationality: Biological and Artificial Intelligence Systems

Andrei Khrennikov

Subject: Social Sciences, Psychology Keywords: mathematical formalism; quantum mechanics; quantum instruments; psychological effects; cognition; decision making; classical rationality; quantum rationality; information overload

Online: 15 March 2021 (14:12:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1142.v1

The Impact of Psychological Health on Childhood Obesity: A Cross-Developmental Stage Analysis

Georgios Feretzakis, Athanasia Harokopou, Olga Fafoula, Athina Balaska, Antriana Koulountzou, Efstathia Katoikou, Athanasios Anastasiou, Georgios Zagkavieros, Ilias Dalainas, Georgios Gkritzelas

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Childhood Obesity; Psychological Well-being; Bioinformatics; Developmental Stages; Emotional Regulation; Social Dynamics; Adaptive Strategies; Obesity Interventions; Public Health; Pediatric Healthcare

Online: 20 February 2024 (11:59:35 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202405.2169.v1

Neurological and Psychiatric Illness amongst Beggars: A Critical Appraisal of Indian Scienario

Souvik Dubey, Shambaditya Das, Ritwik Ghosh, Mahua Dubey, Alak Pandit

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Beggar; Neurological and psychiatric disease; social perspective; India

Online: 31 May 2024 (15:31:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0245.v1

COVID-19 Comorbidity and Metabolic Syndrome: Is There a Molecular Basis?

Madhurima Basu, Chinmay Saha, Kamalika Roy Choudhury, Susmita Dutta, Sujoy Ghosh, Subhankar Chowdhury, Satinath Mukhopadhyay, Nitai P. Bhattacharyya

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: COVID-19; Metabolic syndrome; Comorbidity; Enrichment analysis; biological processes and pathways

Online: 21 June 2020 (09:52:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1382.v1

Impact of Smoking Cessation and Charlson Comorbidity Index on Influenza Vaccination Efficacy in COPD Patients

Hui-Chuan Chang, Shih-Feng Liu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chronic obstructive pulmonary disease; influenza vaccination; Charlson Comorbidity Index; smoking cessation

Online: 21 May 2024 (11:49:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0097.v1

Greek Norms for the D-kefs Verbal and Design Fluency Subtests in Adult Population between 20–49 Years Old

Marianna Tsatali, Andromachi Konstantinou, Fotini Surdu, Despina Moraitou

Subject: Social Sciences, Psychology Keywords: D-KEFS, design fluency, executive functions, normative data, verbal fluency

Online: 2 September 2024 (13:38:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1368.v1

A Multi-feature Fusion Method for Life Prediction of Automotive Proton Exchange Membrane Fuel Cell Based on TCN-GRU

Jiaming Zhang, Fuwu Yan, Changqing Du, Yiming Zhang, Chao Zheng, Jinhai Wang

Subject: Engineering, Automotive Engineering Keywords: PEMFC; Life prediction; Multi-feature fusion method; TCN-GRU

Online: 20 June 2024 (00:19:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0079.v1

Blood Biomarkers of Alzheimer's Disease and Cognition: A Literature Review

Greta García-Escobar, Rosa-María Manero-Borràs, Aida Fernández-Lebrero, Ángel Ois, Irene Navalpotro-Gómez, Victor Puente-Periz, Jose Contador, Isabel Estragués-Gazques, Albert Puig-Pijoan, Joan Jimenez-Balado

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’ s disease; Cognitive Impairment; Blood biomarkers; Cognitive functions; Cognition

Online: 1 November 2023 (12:00:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0647.v1

Biological Organization Principles: Biogenesis, Cognition and Evolution of Living Systems

Carlos Maureira, Jose Garcia

Subject: Biology And Life Sciences, Other Keywords: Biological Organization Principles; Dynamical Systems; Bayesian Inference and Brian; FEP; Autopoiesis; Evolution; Cognition; Niche; KAM-dynamics Contents

Online: 28 August 2020 (15:08:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2159.v1

Detection and Estimation of Diffuse Signal Components Using the Periodogram

Jesus Selva

Subject: Engineering, Telecommunications Keywords: Periodogram; beamformer; Maximum Likelihood estimation; diffuse components; discrete Chebyshev polynomials; frequency estimation; channel estimation

Online: 27 September 2024 (11:36:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1778.v1

The Sealing of Copper Pipes by Ultrasonic Welding for Heat Pump and Refrigeration Applications

António B. Pereira, Joana D. Batista, Nélia M. Silva, Bernardo Mascate

Subject: Engineering, Mechanical Engineering Keywords: Welding of copper; Sealing copper pipe; Heat pump; Ultrasonic welding

Online: 25 June 2024 (13:50:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1813.v1

Correlations between Selected Blood Markers of Hematological Profile and Milk Components in Dairy Cows

Ryszard Mordak, Jarosław Popiel, Zbigniew Dobrzański, Roman Kołacz, Wiesław Bielas

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: ; dairy cows; blood; hematological profile; milk components; correlations ;

Online: 28 May 2024 (09:47:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0736.v1

Dimensional Accuracy and Mechanical Characterization of Inconel 625 components in Atomic Diffusion Additive Manufacturing

Tobias Rosnitschek, Catharina Stierle, Christian Orgeldinger, Armin Seynstahl, Bettina Alber-Laukant, Stephan Tremmel

Subject: Engineering, Mechanical Engineering Keywords: ADAM; material extrusion; metal additive manufacturing; infill structures

Online: 12 May 2024 (07:44:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0765.v1

Clinical Characteristics of Patients with Psoriatic Arthritis: Association between Sex and Comorbidity

Esther Toledano, Luis Gómez-Lechón, Carolina Cristina Chacón, Cristina Hidalgo, Marta Ibañez, Antonio Marquez, Carlos Montilla

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Arthritis Psoriatic; Gender perspective; Comorbidities ;

Online: 14 February 2024 (09:41:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0296.v1

BODE Index Correlated with Charlson Comorbidity Index and Medical Burden in COPD

Li Chin Ling, Lin Mei-Hsin, Tsai Yuh-Chyn, Chen Pei-Shiuan, Shen Lien-Shi, Kuo Ho-Chang, Liu Shih-Feng

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: chronic obstructive pulmonary disease; bode index; charlson comorbidity index; medical burden

Online: 26 September 2019 (09:58:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0962.v1

Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Which Differences between Alcohol, Cannabis and Psychostimulants?

Martina Di Paolo, Antonia Calabrese, Guido Nosari, Valentina Ciappolino, Luisa Cirella, Alice Caldiroli, Enrico Capuzzi, Massimo Clerici, Massimiliano Buoli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: alcohol; cannabis; clinical variables; peripheral biomarkers; psychostimulants; substance-induced psychotic disorder

Online: 19 February 2024 (14:34:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.1037.v1

Exploring Dietary Interventions in Autism Spectrum Disorder

Ingrid Daniela Pérez-Cabral, Ariadna Thalía Bernal-Mercado, Alma Rosa Islas-Rubio, Guadalupe Miroslava Suárez-Jiménez, Miguel Ángel Robles-García, Andrés Leobardo Puebla-Duarte, Carmen Lizette Del-Toro-Sánchez

Subject: Biology And Life Sciences, Food Science And Technology Keywords: autism spectrum disorder; nutrition; vitamins; oxidative stress; diets; food selectivity; gastrointestinal disorders.

Online: 14 August 2024 (19:45:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints201906.0192.v1

Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders

Arturo Andrade, Ashton Brennecke, Shayna Mallat, Julian Brown, Juan Gomez-Rivadeneira, Natalie Czepiel, Laura Londrigan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: voltage-gated calcium channels; major depressive disorder; autism spectrum disorder; schizophrenia; bipolar disorder; attention-deficit and hyperactivity disorder; anxiety; calcium channel modulators; psychiatric disorders; auxiliary subunits; genetic risk variations

Online: 20 June 2019 (04:16:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1730.v1

Effect of the Mineralogical Composition of Sandstones on the Wear of Mining Machinery Components

Andrzej N. Wieczorek, Iwona Jonczy, Krzysztof Filipowicz, Mariusz Kuczaj, Arkadiusz Pawlikowski, Kamil Mucha, Anna Gerle

Subject: Engineering, Mining And Mineral Processing Keywords: wear; sandstone; tribology; wear-resistant steels

Online: 27 May 2024 (10:28:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0302.v1

Colors of Autism Spectrum: A Single Paradigm Explains the Heterogeneity in Autism Spectrum Disorder

Andras Lorincz

Subject: Social Sciences, Psychology Keywords: autism, cognition, components, psychiatric impairments, comorbidity

Online: 24 April 2018 (01:02:55 CEST)

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We propose a theory of ASD as a condition of comorbid cognitive impairments that corrupt the learning, encoding, and manipulation of episodic and semantic memories. We consider (i) episodic and semantic memory functions of the entorhinal-hippocampal complex, (ii) constraints on the transfer and encoding of these memory components into neocortical areas, and (iii) the demands of cognitively manipulating memories in distributed computations being necessary for goal oriented interactions. In ASD, learning and cognitive challenges manifest in diverse ways but especially in high-complexity model predictive control tasks with latent variables. ASD impairments in social interactions represent a prototypical example. Social interactions are at the high end of complexity and require processes (i)–(iii) to work in a concerted fashion due to the need for the learning and estimation of many, sometimes latent, parameters, including emotions, intention, physical and mental capabilities as well as the predictive modeling of these parameters for decision making and timed-action series. We put forth the idea that autism is a result of an arbitrary combination of otherwise not prominent corruptions in processes (i)–(iii). Together, these corruptions may severely impair intelligence and slow down learning, especially in high complexity learning tasks. Over time, slow learning may spare the spontaneous learning-by-doing method - namely, repetitive behavioral patterns, whereas behavioral failures related to complex tasks can restrict interest in such task, thus inducing a fear of novelty; conversely, the fear of novelty restricts interest and can slow learning down. We embed our thoughts into a predictive autoencoding, goal-oriented model of a deterministic world. We compare this model to others, such as the noisy brain model, the Bayesian prior theory, the mirror neuron theory and the weak central coherence theory. We argue that the predictive autoencoder model of the deterministic world harmonizes with these other models and embraces them in a straightforward way.

Preprint ARTICLE | doi:10.20944/preprints202409.0476.v1

Optimizing Recovery in Patients with Dual Impairments: Proprioception and Balance Enhancement through Combined Vestibular and Knee Rehabilitation

Patricia-Maria Crișan-Mălăncrăvean, Klara Brînzaniuc, Pal Fodor, Gheorghe Mühlfay

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Proprioceptive function; integrated rehabilitation; vestibular rehabilitation; gait stability; balance and motor control

Online: 6 September 2024 (05:58:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0268.v1

Leishmaniases and Schistosomiasis Comorbidity Potential in Kenya: The Need for Follow Up Studies

Christopher Khayeka-Wandabwa, Christopher O. Anjili, Venny C.S. Nyambati, Lydiah H. Kutima, Joseph K. Choge, Lucy K. Karani, William. Kipchirchir Kemei

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Concomitance; Schistosomiasis; Comorbidity; Leishmaniases; Th1 and Th2

Online: 13 October 2020 (09:44:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.0135.v1

Deciphering Deception – the Impact of AI Deepfakes on Human Cognition and Emotion

Jamshir Qureshi, Samina Khan

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: AI deepfakes; human cognition; emotion; perception; decision-making; neuroimaging; psychophysiology; behavioral analysis; individual differences; misinformation; ethical implications

Online: 2 February 2024 (07:50:05 CET)

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AbstractThe emergence of AI-powered deepfakes, manipulatively realistic synthetic media, raises unprecedented challenges for human information processing and decision-making. This paper explores the cognitive and emotional consequences of exposure to deepfakes, delving into how these digitally fabricated experiences can reshape perception, trust, and social interactions. By reviewing existing research and outlining potential methodological approaches, this paper aims to establish a framework for investigating the multifaceted impact of deepfakes on the human brain.BackgroundThe digital age has ushered in an era of unprecedented information abundance and accessibility. Yet, this abundance breeds vulnerability, particularly with the emergence of AI-powered deepfakes. These hyper-realistic synthetic media creations present a potent threat to the fundamental trust and integrity of information sources. Deepfakes have infiltrated various domains, from entertainment and social media to politics and journalism, blurring the lines between truth and fabrication. Consequently, understanding the cognitive and emotional consequences of encountering deepfakes becomes crucial for navigating this increasingly deceptive landscape.ObjectivesThis research aims to: Investigate how exposure to deepfakes impacts various cognitive functions, including perception, attention, memory, and decision-making. Elucidate the emotional responses elicited by deepfakes and their underlying neural mechanisms. Evaluate the role of individual differences, such as susceptibility to deception and emotional sensitivity, in mediating the impact of deepfakes. Develop a comprehensive framework for understanding the multifaceted influence of deepfakes on the human brain. Results (anticipated)This research is expected to yield insights into: The specific cognitive and emotional processes altered by deepfakes, providing evidence for potential mechanisms of deception and manipulation. The neural circuitry involved in detecting and responding to deepfakes, leading to the development of more effective detection methods. The influence of individual differences (e.g., age, cognitive style) on susceptibility to deepfakes, informing targeted interventions and educational efforts.ConclusionBy deciphering the impact of deepfakes on the human brain, this research will offer valuable tools for mitigating the harmful consequences of misinformation and promoting responsible use of this powerful technology. Ultimately, understanding how deepfakes manipulate our cognitive and emotional landscape is not merely a scientific pursuit, but a critical step towards ensuring a future where truth prevails in the digital world.

Preprint REVIEW | doi:10.20944/preprints201811.0171.v1

Microbiota-Gut-Brain-Axis and Autism Spectrum Disorders

Piranavie Srikantha, M. Hasan Mohajeri

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Autism, ASD, microbiota, gut-brain-axis, microbiota-gut-brain-axis, therapy

Online: 7 November 2018 (14:45:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1451.v1

Management’s Discretionary Assessments of Goodwill Impairments—Evidence from STOXX Europe 600

Frode Kjærland, Kristian Forbord, Are Oust, Håkon Stephani

Subject: Business, Economics And Management, Accounting And Taxation Keywords: goodwill impairment; IFRS; earnings management; company-specific factors; fixed effects

Online: 19 May 2023 (16:49:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0389.v1

A Comprehensive Review of the Variability of Bovine Colostrum Components and Their Effect on Neonatal Calf Physiology

Flávio Gomes Da Silva, Severiano R. Silva, Alfredo M.F. Pereira, Joaquim Lima Cerqueira, Cristina Conceição

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Bioactive components; Cell; Gut maturation; Nutrition; Microbiome; Passive immune transfer; Thermoregulation

Online: 8 March 2024 (01:55:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0175.v1

Lowered Serum Cesium Levels in Schizophrenia: Association with Immune-Inflammatory Biomarkers and Cognitive Impairments

Abbas F. Almulla, Shatha Rouf Moustafa, Arafat Hussein Al-Dujaili, Hussein Kadhem Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: inflammation; neuroimmunomodulation; major depression; chronic fatigue syndrome; myalgic encephalomyelitis; biomarkers

Online: 14 February 2020 (01:53:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1093.v1

Raising Awareness of the Importance of Early Diagnosis of Children with Autism Spectrum Disorders (ASD)

Adrian-Nicolae DAN, Nina Stănescu

Subject: Social Sciences, Sociology Keywords: Autism Spectrum Disorders (ASD); early diagnosis / screening; early intervention; social services

Online: 17 April 2024 (14:03:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1563.v1

Comparative Studies of Bioactivities and Chemical Components in Fresh and Black Garlics

Kanako Matsuse, Sho Hirata, Mostafa Abdelrahman, Tetsuya Nakajima, Yoshihito Iuchi, Satoshi Kambayashi, Masaru Okuda, Kimiko Kazumura, Benya Manochai, Masayoshi Shigyo

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Allium sativum; black garlic; functional food; anticancer activity; processed food

Online: 26 March 2024 (11:33:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1756.v1

Comorbidity genes of Alzheimer’s disease and type 2 diabetes associated with memory and cognitive function

Seong Beom Cho

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; type 2 diabetes; comorbidity; memory; cognition.

Online: 22 December 2023 (15:04:19 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202309.0196.v1

Receptor-Independent Antipsychotic Therapies for Forensic Detainees with Schizophrenia-Dementia Comorbidity

Adonis Sfera, Luminita Andronescu, William G Britt, Kiera Himsl, Carolina Klein, Leah Rahman, Zisis Kozlakidis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Neurodegenerative disorders; schizophremia; PDK1 inhibitors; Lipid replacement therapy; Aryl hydrocarbon receptor antagonists

Online: 4 September 2023 (14:29:13 CEST)

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Abstract Forensic institutions throughout the country house patients with severe psychiatric illness and history of criminal violations. Improved medical care, hygiene, and nutrition led to unmatched longevity in this population which previously lived on average 15 to 20 years shorter than the public at large. On the other hand, longevity has contributed to increased prevalence of age-related diseases, including neurodegenerative disorders, which complicate clinical management. Forensic institutions, originally intended for the treatment of younger individuals, are ill-equipped for the growing number of older offenders. Moreover, as antipsychotic drugs became available in 1950s and 1960s, we are observing the first generation of forensic detainees who had aged on dopamine blockers. Although the consequences of long-term treatment with these agents are unclear, schizophrenia-associated gray matter loss, may contribute to the development of early dementia. Taken together, increased lifespan and subsequent cognitive deficit observed in long-term psychiatric institutions brought forth questions and dilemmas unencountered by the previous generations of clinicians, such as: 1. Does the presence of neurocognitive dysfunction justify antipsychotic dose reduction or discontinuation despite a lifelong history of schizophrenia and violent behavior? 2. Should neurolipidomic interventions become the standard of care in elderly individuals with lifelong schizophrenia and dementia? 3. Can patients with schizophrenia and dementia meet the Dusky standard and stand trial? 4. Should neurocognitive disorders in elderly with lifelong schizophrenia be treated differently than age-related neurodegeneration? In this article, we describe strategies for potentially slowing the development of neurocognitive disorders in forensic patients with chronic mental illness by adopting a three-prong strategy: 1. Approaching lifelong psychosis from microbial and immunological perspective. 2. Identify modifiable risk factors for age-related diseases in forensic institutions. 3. Utilizing novel receptor-independent treatments for chronic psychosis.

Working Paper COMMUNICATION

Pressure Point Threshold Scores and ME/CFS Comorbidity as Indicators of Patient´s Response to Manual Physiotherapy in Fibromyalgia

Francisco Javier Falaguera-Vera, María Garcia-Escudero, Javier Bonastre-Férez, Mario Zacarés, Elisa Oltra

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Fibromyalgia; Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); Pressure Point Threshold (PPT); Physiotherapy; Manual Therapy (MT)

Online: 15 September 2020 (09:01:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1424.v1

Social Inhibition and Depressive symptoms among Couples Having Children with Autism Spectrum Disorder: The Mediating Role of Perceived Family Support

Ting Pan, Tinakon Wongpakaran, Nahathai Wongpakaran, Bijing He, Danny Wedding

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: social inhibition; autism; depression; family support; parents; actor partner interdependence mediation model

Online: 26 February 2024 (10:26:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0043.v1

Symptom Severity Changes in Obsessive-Compulsive Patients during COVID-19 Pandemic Are Associated with Shorter Illness Duration and Benzodiazepine Use: Possible Evolutionary Advantage of a Psychiatric Disorder

Giordano D’Urso, Alfonso Magliacano, Marco Manzo, Mattia Vittorio Pomes, Carla Iuliano, Felice Iasevoli, Bernardo Dell'Osso, Andrea De Bartolomeis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: obsessive-compulsive disorder; COVID-19; clinical evolution; adaptive psychopathology; illness duration; anxious diathesis

Online: 1 March 2024 (17:40:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0564.v2

Possibility of Assessing Pain with Biomarkers in Psychiatric Disorders

Piotr Jakubow, Urszula Kosciuczuk, Adam Garkowski, Aleksander Turczynowicz, Małgorzata Mojsak, Łukasz Skoworński

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: psychiatric disorders; neuroimaging; biochemical; pain; pain biomarkers

Online: 21 June 2021 (16:39:16 CEST)

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According to the literature, patients with chronic pain and mental disorders constitute a huge, heterogeneous group. However, it is known that social and psychological processes closely affect the level and expression of chronic pain. In this paper, we present a review of the literature, define methods of identifying pain biomarkers and consider the possibility of using them to assess pain in mental disorders. Group researchers searched PubMed, Scope, and Cochrane databases for "pain biomarkers in mental disorders" between 2011 and 2021. for available databases for full-text, peer-reviewed studies and review publications using the following keywords: pain biomarkers, neuroimaging pain, pain metabolomics, pain and psychiatric disorders, pain electroencephalography (EEG), serum pain biomarkers, saliva biomarkers, and diagnosis pain. The search included full-text articles, clinical trials, randomized controlled trials, and systematic reviews. Was used part of the PRISMA method to review the literature systematically. A literature search identified 283 studies based on the initially set inclusion and exclusion criteria. In the subsequent selection stages, 11 studies were selected for analysis. There are three main areas of the possible use of biomarkers for the clinical assessment of pain in psychiatric patients, neuroimaging, changes in metabolite levels in body fluids, and changes in gene expression. As a result of the review, individual pain mediators were distinguished that may be markers of pain in psychiatric patients. Some mediators indicate the specificity of pain and are of diagnostic importance. However, despite significant advances in research, most of the described biomarkers found in clinical trials assessing the severity and frequency of pain have no practical significance in psychiatric disorders. It is possible to diagnose pain based on neuroimaging using various methods, genetic methods, body fluids: blood and urine. Of the many, body fluid biomarkers are the most advanced. Discussion: Biomarker research is a dynamically developing field. The review has proposed new ways to diagnose pain by identifying pain biomarkers. Work presented pain diagnostics in psychiatric disorders based on biomarkers from various neuroimaging methods, blood and urine analysis. The possibility of new, effective techniques gives hope for the correct diagnosis of pain, especially in patients with mental disorders, which would allow for appropriate and adequate therapeutic therapies. In clinical practice is limited to a few methods. Assessment of pain biomarkers in body fluids (serum, saliva, and urine) seems to be the most practical and promising method of clinical application. Conclusions: There are new techniques that give hope for the correct diagnosis of pain, especially in patients with mental disorders, which will allow for their proper and adequate therapy. According to the literature, patients with chronic pain and mental disorders constitute a huge, heterogeneous group. However, it is known that social and psychological processes closely affect the level and expression of chronic pain.

Working Paper REVIEW

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Simge Seren Kirlioglu, Yasin Hasan Balcioglu

Subject: Social Sciences, Behavior Sciences Keywords: biological clocks; circadian rhythm disorders; mental disorders; melatonin; HPA-axis

Online: 16 May 2020 (17:18:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0080.v1

Multivariate Analysis of Structural and Functional Neuroimaging Can Inform Psychiatric Differential Diagnosis

Drozdstoy Stoyanov, Sevdalina Kandilarova, Katrin Aryutova, Rositsa Paunova, Anna Todeva-Radneva, Adeliya Latypova, Ferath Kherif

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: multivariate linear method; validation; diagnosis; discriminative; signatures of disease; schizophrenia; depression

Online: 3 December 2020 (10:38:31 CET)

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Working Paper HYPOTHESIS

On the Emergence of Cognition and Consciousness: From Catalytic Closure to Neuroglial Closure

Jose Luis Perez Velazquez

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: consciousness; cognition; life; equivalence relation; synchrony; compartmentalization; closure; connectivity

Online: 16 February 2020 (15:01:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0716.v1

Ceramides Mediate Insulin-Induced Impairments in Cerebral Mitochondrial Bioenergetics in ApoE4 Mice

Sheryl T. Carr, Erin R. Saito, Chase M. Walton, Jeremy Y. Saito, Cameron M. Hanegan, Cali E. Warren, Annie M. Trumbull, Benjamin T. Bikman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: insulin resistance; Alzheimer’s disease; ApoE4; dyslipidemia; ceramides; mitochondrial bioenergetics; cerebral cortex

Online: 12 September 2023 (14:19:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0359.v1

Pathogenicity of Endocrine Dysregulation in Autism

Adam J. Swierczynski

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: autism spectrum disorder; endocrine; estrogen; immune activation; melanin concentrating hormone

Online: 25 May 2018 (10:37:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2127.v1

Longitudinal Analysis of Social Isolation and Cognitive Functioning Among Hispanic Older Adults with Sensory Impairments

Corinna Trujillo Tanner, Jeremy Yorgason, Avalon White, Chresten Armstrong, Antonia Cash, Rebekah Case, Joshua R. Ehrlich

Subject: Social Sciences, Ethnic And Cultural Studies Keywords: Hispanic; Familism; Vision Impairment; Hearing Impairment; Social Isolation; Cognitive Functioning

Online: 30 May 2023 (11:28:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0465.v1

Epigenetics and the Environmental Landscape of Autism Spectrum Disorders

German Torres, Mervat Mourad, Saba Iqbal, Emmanuel Moses-Fynn, Ashani Pandita, Shriya S. Siddhartha, Riya A. Sood, Kavya Srinivasan, Riya T. Subbaiah, Alisha Tiwari, Joerg R. Leheste

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: lleles; Brain; Disease; Genes; Gastrointestinal Tract; Mutations; Epigenetics; Evolution; Phenotypes

Online: 4 August 2023 (19:17:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1657.v1

Displacement Mapping as a Highly Flexible Surface Texturing Tool for Additively Photopolymerized Components

Robert Bail, Dong Hyun Lee

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: mesh modeling; resin printing; surface finish; random texture; nature-inspired surfaces

Online: 27 March 2024 (08:23:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0900.v1

Elif Funda Sener, Halime Dana, Reyhan Tahtasakal, Serpil Taheri, Minoo Rassoulzadegan

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Cc2d1a; Autism; microRNA; transcripts; DNA/RNA hybrid; non-Mendelian heredity

Online: 11 July 2024 (10:04:34 CEST)

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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, with a highly variable expression of phenotypes (restricted interest or activity and repetitive behavior in communication and social interactions), genes (mutation), markers (alteration of transcription) and pathways. Loss of function of the CC2D1A gene appears to primarily affect the brain, leading to a range of behavioral problems in humans. In our study published in 2020; we found that the expressions of miR-19a-3p, miR-361-5p, miR-150-5p, miR-3613-3p, miR-126-3p and miR-499a-5p were downregulated in the serum samples of autistic patients and their families. Here, acquired non-Mendelian hereditary character in a genetically defined mouse model of autism (Cc2d1a +/-) correlates with the transcriptional alteration of five miRNAs. We seek to test the hypothesis that miRNA levels are varying by changes in RNA/DNA structure during development, thereby creating transcription alteration. Behavioral tests were conducted on the offspring of Cc2d1a +/- mutant and control mice, such as novel object, social interaction, marble burying and tail suspension behavior. Two RNA fractions were isolated from mouse hippocampal tissues and sperm cells by standard TRIzol extraction: total RNA and fraction of RNA bound to DNA in the form of a DNA/RNA hybrid (R-loop). The expression levels of miR-19a-3p, miR-361-5p, miR-150-5p, miR-126-3p and miR-499a-5p were investigated by quantitative real-time RT-PCR. We report differences in the distribution of five miRNAs in the hippocampus between male and female mice in RNA fractions, particularly in colonies of Cc2d1a +/- mice. Furthermore, the number of miRNAs engaged in the DNA/RNA hybrid fraction is generally higher in the mutant pedigree than in the control group. On the other hand, in sperm both fractions are at lower levels than in controls. R-loops contribute to the physiology and pathology of organisms including human disease. Here we report a variation in five miRNA levels between gender and tissue. Our results suggest that the transcription levels of these five miRNAs are directly regulated by their RNA.

Preprint ARTICLE | doi:10.20944/preprints202106.0403.v1

Comparison of Indexes to Measure Comorbidity Burden and Predict All-Cause Mortality in Rheumatoid Arthritis

Yun Ju Huang, Jung Sheng Chen, Shue Fen Luo, Chang Fu Kuo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Charlson Comorbidity Index; Elixhauser Comorbidity Index; Multimorbidity index; Rheumatic Disease Comorbidity Index; Rheumatoid arthritis; Cormorbidity index

Online: 15 June 2021 (12:01:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1908.v1

What Is a Disease for Doctors? A Realist Thematic Analysis and Implications for Medical Education

Fabrizio Consorti, Rossella Melcarne, Domenico Pisanelli, Chiara Scorziello, Laura Giacomelli

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: disease; illness; philosophy of medicine; critical realism

Online: 29 April 2024 (10:33:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1324.v1

Brief Cognitive Behavioral Therapy for Depression and Anxiety in Patients With Schizophrenia in Psychiatric Home Nursing Service: Pilot Randomized Controlled Trial

Masayuki Katsushima, Eiji Shimizu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; depression and anxiety; brief cognitive behavioral therapy; psychiatric home nursing; workbook

Online: 19 June 2024 (08:42:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1337.v1

Ana Pjevac, Teodora Safiye, Mirjana Jovanovic

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: internet addiction, adolescents, temperament, online, IAT, TEMPS

Online: 23 February 2024 (09:10:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0353.v1

Histopathological and Behavioral Impairments in Zebrafish (Danio rerio) Chronically Exposed to a Cocktail of Fipronil and Pyriproxyfen

Madalina Andreea Robea, Adriana Petrovici, Dorel Ureche, Mircea Nicusor Nicoara, Alin Stelian Ciobica

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: pesticide; fipronil; pyriproxyfen; behavior; histopathological changes; zebrafish

Online: 6 July 2023 (10:11:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0980.v1

Does the Metabolic Syndrome and Its Components Have Prognostic Significance for Renal and Cardiovascular Outcomes in IgA Nephropathy?

Balázs Sági, Tibor Vas, Botond Csiky, Judit Nagy, Tibor József Kovács

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Chronic kidney disease; IgA nephropathy; Renal function; Metabolic syndrome; Arterial stiffness

Online: 15 April 2024 (14:53:42 CEST)

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Background: Cardiovascular (CV) morbidity and mortality are many times higher in chronic kidney disease (CKD), as well as IgA nephropathy (IgAN), than in the general population. The occurrence of metabolic syndrome (MetS) and metabolic risk factors are independent risk factors for CV disease and renal progression. The study aimed to determine the prognostic role of metabolic profiles in a homogenous group of CKD patients. Methods: One hundred and forty-five IgA nephropathy patients (92 male, 53 female, age 54.7 ± 13 years) with CKD stage 1-4 were investigated and followed for a median of 190 months. The composite (CV and renal) endpoints included all-cause mortality and any CV event such as stroke, myocardial infarction, revascularization (CV), end-stage renal disease, and renal replacement therapy (renal). Results: Patients with MetS had significantly more endpoint events (16/27 patients vs. 15/98 patients, p = 0.001) compared to the nonMetS group. Of the secondary endpoints (CV or renal separately), the rate of the renal and CV endpoints was significantly higher in the MetS group (p = 0.001 and p = 0.029). The primary endpoint independent predictors of survival were dyslipidemia, eGFR, hemoglobin, urine albuminuria, and diabetes mellitus, as determined by Cox regression analysis. Independent predictors of secondary renal endpoint were dyslipidemia, hemoglobin, urine albumin, and eGFR. Predictors of secondary cardiovascular endpoints were gender, BMI, and diabetes. Kaplan-Meier curves showed significant differences in MetS and non-MetS when examined at the combined endpoints (CV and renal) or at each endpoint separately. The primary endpoint rate increased significantly with the increased number of MetS components (MetS comp. 0 vs. MetS comp. 2+, primary endpoints, p = 0.012). Conclusion: Our results showed that the metabolic profile has a prognostic role not only for renal endpoints but also for CV endpoints in IgAN. BMI, hyperuricemia, hypertension, and diabetes have a predictive value for the prognosis of IgA nephropathy.

Preprint ARTICLE | doi:10.20944/preprints202307.1916.v1

Cognition and Interaction: From the Perspective of Daily Therapeutic Landscape of the Coastal Zone

Shu-Chen Tsai, Hui Wang, Su-Hsin Lee, Zhe Zou

Subject: Arts And Humanities, Humanities Keywords: Frequency; Restoration; Interaction; Daily life; Human geography

Online: 27 July 2023 (13:27:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0270.v1

Comparison of Model Systems for Emulating Human Tissue and Physiology in Psychiatric Research

Kai Cheng, Annie Kathuria, Anannya Kshirsagar, John Nixon, Jonathan Lau, Kun Yang, Akira Sawa

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Psychiatric Disorders; Diseases Modeling; Organoids; Stem Cells; Monolayer Culture

Online: 5 August 2024 (10:38:47 CEST)

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The modeling of psychiatric disorders poses significant challenges due to the complex nature of these conditions, which encompass a range of neuropsychiatric diseases such as autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar disorder (BD), post-traumatic stress disorder (PTSD), anxiety and depression. The rising global prevalence of mental disorders and the urgency for more effective treatments have propelled the development of innovative in vitro models. This review presents a thorough examination of two-dimensional (2D) versus three-dimensional (3D) induced pluripotent stem cell (iPSC) models of neuropsychiatric diseases, offering insights into their respective capacities to mimic neurodevelopment and cellular phenotypes observed in these conditions. Our comparative analysis reveals that while traditional 2D cultures have been instrumental in elucidating disease pathways and high-throughput drug screening, they fall short in replicating the intricate cellular architecture and environment of the human brain. On the other hand, 3D organoid models, including brain organoids, better recapitulate the spatial organization, cell-type diversity, and functional connectivity of brain tissue, offering a more physiologically relevant context for studying disease mechanisms and testing therapeutic interventions. We assess the progress in modeling ASD, Schizophrenia, Bipolar Disorder, PTSD, and depression, highlighting the advanced understanding of disease etiology and potential treatment avenues offered by 3D iPSC technologies. Challenges remain, including the scalability, reproducibility, and maturation of organoids, but the potential for personalized medicine and the elucidation of disease ontogeny is unparalleled. The review concludes with a perspective on the future directions of psychiatric disease modeling, emphasizing the integration of 3D iPSC models with high-throughput technologies and computational approaches to enhance our understanding and treatment of these debilitating conditions.

Preprint ARTICLE | doi:10.20944/preprints202407.0090.v1

Insights into Psychiatric Diseases Represented by Wave Equations: A Mathematical and Graphical Exploration

Richard Montgomery

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Keywords: Psychosis, Bipolar Disorder and Obsessive Compulsive Disorder, Simulation with waves and differential equations

Online: 1 July 2024 (13:13:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0259.v1

From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders

Masaru Tanaka, László Vécsei

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: psychosis; Parkinson's disease; antioxidants; genetic therapy; stroke; anxiety; migraine; epilepsy; aphasia; cardiovascular diseases; cognition

Online: 5 March 2024 (12:31:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2002.v1

Navigating the Complex Intersection of Substance Use and Psychiatric Disorders: A Comprehensive Review

Anees Bahji

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: comorbidity; substance use disorders; psychiatric disorders; treatment interventions; dual diagnosis

Online: 29 January 2024 (12:52:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0204.v1

Professional Quality of Life, Job Satisfaction, and Intention to Leave Among Psychiatric Nurses

Shaher Hamaideh, Abdallah Abu Khait, Hanan Al-Modallal, Rami Masa'deh, Ayman Hamdan-Mansour, Mohammed AlBashtawy

Subject: Public Health And Healthcare, Nursing Keywords: ProQoL; job satisfaction; intention to leave; psychiatric nurses; Jordan

Online: 5 December 2023 (04:46:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.0151.v1

Epididymis May Be More Important in Male Fertility than Our Cognition

Meng-Meng Liu, Hao Shang, Xin-Lei Feng, Chao Qi, Shu-Er Zhang, Yuan-Chao Sun, Chun-Yang Gou, Yu-Jiang Sun, Guo-Liang Zhang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Epididymis; Regional; Single cell/Spatial Transcriptomics

Online: 3 May 2023 (12:43:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1975.v1

Biomarkers: The Key To Enhancing Dbs Treatment For Psychiatric Conditions

Guillermo Jose Bazarra Castro, Vicente Casitas, Carlos Martinez-Macho, Alejandra Madero Pohlen, Amelia Alvarez-Sala, Enrique Barbero Pablos, José Fernández Alén, Cristina V. Torres

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Deep Brain Stimulation (DBS); Psychosurgery; Depression; Obsessive-Compulsive Disorder (OCT); Biomarkers; Diffusion tensor imaging (DTI)

Online: 25 September 2024 (12:46:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1757.v1

Two-Timescale Design for RIS-Aided Multicell MIMO Systems with Transceiver Hardware Impairments

Shilong Zhang, Weiran Guo, Jianxin Dai, Feng Zhu

Subject: Engineering, Telecommunications Keywords: Two-timescale, reconfigurable intelligent surface (RIS), massive multiple-input multiple-output (mMIMO), transceiver hardware impairments (THWIs)

Online: 22 December 2023 (15:01:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.1216.v1

Autism Spectrum Disorder and BRIEF‐P: A Review and Meta‐Analysis

Esperanza Bausela-Herreras

Subject: Social Sciences, Psychology Keywords: BRIEF-P; flexibility; Executive Functions; inhibition; Miyake model; working memory; Autism Spectrum Disorder

Online: 15 July 2024 (17:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0391.v2

Evaluation and Prioritization of 7P’s Components Using AHP in the Structure of the Economic Sectors Model to Reach Target Market

Sina Pournayebzadeh, Manouchehr Ansari, Nastaran Ghanbarian Alavijeh

Subject: Business, Economics And Management, Marketing Keywords: business management; business strategy; economic sectors model; marketing mix (7P); hierarchical analysis process model (AHP); target market

Online: 2 September 2024 (10:53:07 CEST)

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