BBC Russian

Preprint ARTICLE | doi:10.20944/preprints201608.0170.v1

In Their Own Words: The Health and Sexuality of Immigrant Women with Infibulation Living in Switzerland

Michela Villani, Judith, Louise Griffin, Patrick Bodenmann

Subject: Social Sciences, Sociology Keywords: migration; female genital mutilation; sexual health; reproductive health; communication

Online: 18 August 2016 (05:30:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1154.v1

Oxidative Stress and ROS Linking Diabetes and Cancer

Homer S. Black

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer; Diabetes; ROS; Oxidative stress; Signaling pathways; Antioxidants’ dual role in cancer

Online: 15 June 2023 (13:54:19 CEST)

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Type 2 diabetes mellitus (T2DM) accounts for one-sixth of deaths, globally, whereas cancer is the second leading cause of death in the U.S. T2DM is a known risk factor for many cancers. This review examines the link of Reactive oxygen Species (ROS)-altered metabolic and signaling pathways in T2DM to cancer. These reprogrammed metabolic and signaling pathways are activated that contribute to diabetic complications, impact redox balance (Oxidative Stress), and have differential roles in early and late stages of cancer. If the respiratory chain is highly reduced (as under hyperglycemic conditions) or if reduced cofactors accumulate, ROS are greatly elevated. ROS may cause mutations in mitochondrial DNA (mtDNA) that result in further ROS elevation. Amplification of ROS results in activation of PKC, an overarching signaling pathway that activates MAPK with subsequent regulation of several factors that result in pathophysiological manifestations of T2DM and cancer. Upregulation of PKC leads to deregulation of NF-kß that regulates the PKB/P13/Akt pathway that orchestrates cell survival, growth, proliferation, and glucose metabolism manifested in cancer. It also affects Insulin Receptor Substrate (IRS-1), decreasing insulin stimulated glucose transport and glucose uptake, disrupting subsequent cell signaling pathways contributing to the development of T2DM. Dyslipidemia is a hallmark of T2DM and cancer. ROS-induced lipid peroxidation leads to systemic inflammation, producing inflammatory prostaglandins, cytokines and chemokines that result in tumor proliferation, rapid tumor growth, and modulation of immunity. The dual role of ROS in early and late stages of cancer make antioxidant therapy precarious and may be responsible for controversial results. A system that delivers an antioxidant directly to mitochondria may be useful in inhibiting formation of ROS early during the pre-diabetic stage whereas antioxidant therapy must be halted in later stages to retard metastasis.

Preprint REVIEW | doi:10.20944/preprints201807.0217.v1

Prevention of Cervical Cancer in Sub-Saharan Africa: the Promises and Challenges of HPV Vaccination

Eleanor Black, Robyn Richmond

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cervical cancer; HPV vaccination; sub-Saharan Africa

Online: 12 July 2018 (14:32:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1643.v1

Vaccinating Against a Novel Pathogen: A Critical Review of COVID-19 Vaccine Effectiveness Evidence

Bernard Black, David B Thaw

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; SARS-CoV-2; vaccine; vaccine efficacy; vaccine effectiveness, vaccine booster; BNT162b2; mRNA1273; Ad26.COV2.S; ChAdOx1-S; SARS-CoV-2 variants

Online: 28 November 2023 (01:41:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0168.v1

Sensory Neuromodulation

Robert D. Black, Lesco L. Rogers

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neuromodulation, noninvasive, sensory networks

Online: 7 November 2018 (14:40:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1713.v1

Mechanism and Synergy Effect of the Hybrid Water Disinfection Process Using Electric Discharges Combined with Chlorination

Antonina Malyushevskaya, Piotr Koszelnik, Olena Mitryasova, Anna Yushchishina, Andrii MATS, Dorota Papciak, Monika Magdalena Zdeb

Subject: Engineering, Electrical And Electronic Engineering Keywords: Keywords: water disinfection; underwater electrical discharges; cavitation; activation of liquid.

Online: 25 June 2024 (07:13:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0395.v1

The Sensitivity of Structure to Ionic Radius and Reaction Stoichiometry. A Crystallographic Study of Metal Coordination and Hydrogen Bonding in Barbiturate Complexes of All Five Alkali Metals Li–Cs

William Clegg, Gary S. Nichol

Subject: Chemistry And Materials Science, Other Keywords: crystal structure; alkali metals; barbituric acid; coordination; stoichiometry; bridging ligands; hydrogen bonding

Online: 8 March 2024 (01:53:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1860.v1

Lateral Ultimate Capacity of Monopile Foundations for Offshore Wind Turbines: Effects of Monopile Geometry and Soil Stiffness Properties

Yazeed Alsharedah, Timothy Newson, M.Hesham El Naggar, Jonathan A. Black

Subject: Engineering, Civil Engineering Keywords: Monopile; offshore wind turbines (OWT); lateral ultimate capacity; green energy

Online: 29 August 2023 (02:59:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1943.v2

Obesity Control and Supplementary Nutraceuticals as Co-Factors of Brain Plasticity in Multiple Sclerosis Populations

Lorena Ciumarnean, Oliviu Florențiu Sârb, Nicu Catalin Draghici, Octavia Salagean, Mircea Vasile Milaciu, Olga Hilda Orasan, Calin Vasile Vlad, Irina Maria Vlad, Teodora Alexescu, Ioana Para, Simina Tarmure, Elisabeta Ioana Hiriscau, Gabriela Bombonica Dogaru

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: multiple sclerosis; neurodegeneration; neurorehabilitation; nutraceuticals; obesity

Online: 9 September 2024 (04:39:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1128.v1

Genetic Factors Contributing to the Pathogenesis of Essential Hypertension in Two African Populations

Kusha Kalideen, Brian Rayner, Raj Ramesar

Subject: Biology And Life Sciences, Other Keywords: essential hypertension; South Africa; Mixed Ancestry; Xhosa; RAAS; AGTR1; AGT; ACE; CYP11B2

Online: 20 February 2024 (09:20:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1894.v1

Diverse Fatty Acid Profiles and Antioxidant Properties in Different Populations of Ox Tongue (Echium amoenum) Fisch. & Mey

Zohreh Emami Bistgani, Vahid Rowshan Sarvestani, Masoud Hashemi

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Ox tongue; Fatty acids; Antioxidant; α-linolenic acid

Online: 24 September 2024 (10:59:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1224.v1

Blockchain based Licensed Spectrum Fair Distribution Method Towards 6G-envisioned Communications

Mengjiang Liu, Qianhong Wu, Dawei Li, Yiming Hei

Subject: Engineering, Telecommunications Keywords: 6G; Licensed spectrum distribution; Blockchain; Fairness

Online: 18 July 2023 (14:16:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0064.v1

Modelling of Metallic Particle Binders for Increased Part Density in Binder Jet Printed Components

Joseph Roberts, Peter Green, Kate Black, Christopher Sutcliffe

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Binder Jetting; Additive Manufacturing; Simulation; Powder bed; Density; Shrinkage

Online: 6 November 2019 (11:40:48 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints201703.0062.v1

Biochemical Compositions of Black Carpenter Ant, Camponotus pennsylvanicus

Francis Olawale Abulude, Samuel Dare Fagbayide

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: biochemical composition; carpenter ants; potassium; phytate

Online: 13 March 2017 (08:38:03 CET)

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Preprint ESSAY | doi:10.20944/preprints202001.0107.v1

Ten Recommendations for Supporting Open Pathogen Genomic Analysis in Public Health Settings

Allison Black, Duncan R. MacCannell, Thomas R. Sibley, Trevor Bedford

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: pathogen genomics; public health; bioinformatics

Online: 11 January 2020 (11:30:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0161.v1

Mitochondrial Control Region Database in Hungarian Fallow Deer (Dama dama) Populations for Forensic Use

Orsolya K. Zorkóczy, Zsombor Wagenhoffer, Pál Lehotzky, Zsolt Pádár, Petra Zenke

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: wildlife crime; forensic genetics; mitochondrial DNA (mtDNA); control region (CR); fallow deer (Dama dama); random match probability; population study

Online: 4 June 2024 (10:56:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0263.v1

New Evidence of the Bidentate Binding Mode in 3-MBA Protected Gold Clusters: Analysis of Aqueous 13–18 kDa Gold-Thiolate Clusters by HPLC-ESI-MS Reveals Special Compositions Au_n(3-MBA)_p, (n = 48 – 67, p = 26-30)

David M. Black, M. Mozammel Hoque, Germán Plascencia-Villa, Robert L. Whetten

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: 3-MBA; gold clusters; ESI-MS; HPLC-MS; bidentate binding

Online: 26 August 2019 (11:08:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0301.v7

Our Symmetric, Complex, and Translucent Universe

Christopher Laforet

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Cosmology; Black holes; Dark Energy; Schwarzschild metric

Online: 23 May 2022 (10:35:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0231.v2

Biological Effect of Amoeba Populations under the Influence of Radiofrequency Electromagnetic Radiation from Cell Phones

Ludmila A. Morozova, Savel'ev Sergey

Subject: Biology And Life Sciences, Biophysics Keywords: cell phone; electromagnetic field; population of protozoan microorganisms; resistance of the aquatic environment

Online: 11 April 2024 (13:22:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0374.v1

The Long-Term Impact of Mild Traumatic Brain Injuries on Multiple Functional Outcomes and Epigenetics: A Pilot Study with College Students

Hyunhwa Lee, Sungchul Lee, Ipuna Black, Laura Salado, Jonica Estrada, Katrina Isla

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: mild traumatic brain injury; mTBI; concussion; cognitive; sensorimotor; visual; postural balance; methylation; 5-mC%; blood

Online: 31 January 2020 (04:28:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0241.v1

Ecology of the Tibetan Antelope (Panthalops Hodgsonii) and Sympatric Ungulate Populations in a Cold Himalayan Desert

Khursheed Ahmad, Parag Nigam, Intesar Suhail

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Tibetan Antelope or Chiru; Sympatric ungulates; Habitat partitioning; Inter-specific Interaction; Population ecology; resource competition; Cold Arid Environment; Conservation management

Online: 5 August 2024 (08:22:05 CEST)

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Sympatric mountain ungulates experience population fluctuations due to intra and inter-specific competition and climate variations. In this comprehensive three-year study (2012-2015), we investigated the population dynamics, spatial distribution, and habitat use of Tibetan Antelope (Chiru) (Panthalops hodgsonii) in relation to four other sympatric ungulates (Argali Ovis ammon, Wild Yak Bos mutus, Tibetan Wild Ass Equus kiang, and Greater Bharal Pseudois nayaur) in the cold arid Changchenmo Valley of Ladakh, India. We conducted 162 intensive surveys covering 918.60 km, we recorded 215 animal sightings, encompassing 1670 Chiru individuals, exclusively males. Chiru exhibited encounter rate of 1.19±1.17 S.D individuals/km walked and 1.53±1.37 S.D. individuals/hr and a typical group sizes of 13.69. Our findings suggest spatio-temporal resource partitioning through habitat selection which favour species coexistence under harsh climatic conditions. While resource sharing occurred during summer, competition was observed during peak winters and springs. Noteworthy in our study was the coexistence of Chiru and Tibetan Wild Ass in shared habitats, indicating facilitation rather than interspecific competition. However, significant habitat segregation was observed between Chiru and other ungulates, highlighting distinct ecological preferences. The study reports a stable Chiru population and reveals a novel phenomenon of some individuals remaining in the area during winters, a behavior not previously documented. The overlap of all species in limited winter habitats poses a potential threat to Chiru survival. Additional threats include climate change, infrastructure development, armed conflict, and livestock competition. Special management efforts, including awareness programs for armed forces and stringent development regulations, are crucial. Our findings provide critical insights into complex species interactions and habitat preferences, forming an essential foundation for the conservation and management of Chiru and other Tibetan ungulates in the Trans-Himalayan landscapes affected by climate change.

Preprint REVIEW | doi:10.20944/preprints202406.1892.v1

Factors Contributing to Alzheimer's Disease in Older Adult Populations: A Narrative Review

Jalal Uddin, Tazveen Fariha, Shahida Sultana Shumi, Farhana Khandoker

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Alzheimer's disease; older adults; risk factors; genetics factors; environmental factors; lifestyle factors

Online: 26 June 2024 (15:01:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0896.v1

New Lie Symmetries and Exact Solutions of a Mathematical Model Describing Solute Transport in Poroelastic Materials

Roman Cherniha Ab, Vasyl' Davydovych, Alla Vorobyova

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: poroelastic material; nonlinear differential equation; Lie symmetry; exact solution

Online: 14 May 2024 (05:03:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0441.v1

Investigating the Performance of a Novel Modified Binary Black Hole Optimization Algorithm for Enhancing Feature Selection

Mohammad Ryiad Al-Eiadeh, Raneem Qaddoura, Mustafa Abdallah

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Feature Selection; Wrapper Feature Selection; Black Hole Algorithm; Cuckoo Search Algorithm; Correlation Functions; Transfer Function; Data Mining

Online: 8 May 2024 (15:26:26 CEST)

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High dimensional datasets are highly likely to have redundant, irrelevant, and noisy features that negatively affect the performance of the classification algorithms. Selecting the most relevant features and reducing the dimensions of datasets by removing the undesired features is a dimensional reduction technique called Feature Selection (FS). In this paper, we propose an FS approach based on the Black Hole Algorithms (BHO) with a mutation technique called MBHO. Generally, BHO contains two major phases. At the exploitation phase, a set of stars are modified based on some rule and according to some objective function, the best star is selected as the black hole which attracts other stars. Furthermore, when a star gets closer to the event horizon, it will be swallowed and a new one will be randomly generated in the search space which thus is the exploration phase. However, randomness may cause the algorithm to fall into the trap of local optima, and to overcome such complications, inversion mutation is used. Furthermore, we modify a widely utilized objective function in most of the proposed works for wrapper feature selection by combining two new terms that are based on the correlation among the selected subset of features and the features and the classification label. We also utilize a transfer function, known as the V2 transfer function, to convert continuous values into discrete ones to enhance search. We assess our approach via extensive evaluation experiments using fourteen benchmark datasets. We benchmark the performance of a wrapper FS approach called Binary Cuckoo Search (BCS), and three filter-based FS approaches (namely Mutual Information Maximisation (MIM), Joint Mutual Information (JMI), and minimum Redundancy Maximum Relevance (mRMR)). Our evaluation has shown that the proposed model is an effective approach for FS, in selecting better features that enhance the performance metrics on the classifiers. Thus, MBHO can be utilized as one alternative to the existing state-of-art-approaches. We release the source codes of our implementation for the community to build on with new methods and datasets.

Preprint REVIEW | doi:10.20944/preprints202006.0078.v1

Transforming Vaccine Development

Steve Black, David E. Bloom, David C. Kaslow, Simone Pecetta, Rino Rappuoli

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; vaccine; vaccine development; vaccine discovery; systems biology; machine learning; platform technologies; adjuvants; smart clinical trials; human genetics; regulatory convergence; real world evidence; vaccines safety

Online: 7 June 2020 (10:11:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1691.v1

The Major Role of T Regulatory Cells in Efficiency of Vaccination in General and Immunocompromised Populations: A Review

Stanislaw Stepkowski, Dulat Bekbolsynov, Jared Oenick, Surina Brar, Beata Mierzejewska

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: vaccines; T cells; T regulatory cells; immunocompromised; vaccine efficacy

Online: 22 July 2024 (08:24:03 CEST)

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Working Paper REVIEW

Flavivirus Persistence in Wildlife Populations

Maria Raisa Blahove, James Richard Carter

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: viral persistence; flaviviruses; mosquito; tick; autophagy; interferon; wildlife; infection; arbovirus

Online: 12 August 2021 (18:28:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1776.v1

Modelling the Herbicide-Resistance Evolution in Lolium rigidum (Gaud.) Populations at the Landscape Scale

Lucia Gonzalez-Diaz, Irene Gonzalez-Garcia, Jose L. Gonzalez-Andujar

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: explicit genotype mode; dispersal vectors; gene flow; population dynamics; operational factors; spatially explicit model

Online: 23 July 2024 (10:02:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0344.v1

Vitamin D Content of Australian Native Food Plants and Australian-Grown Edible Seaweed

Laura J. Hughes, Lucinda J. Black, Jill L. Sherriff, Eleanor Dunlop, Norbert Strobel, Robyn M. Lucas, Janet F. Bornman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: LC-QQQ; liquid chromatography; triple quadrupole; vitamin D; 25(OH)D; plants; algae

Online: 24 May 2018 (09:27:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0101.v1

Analysis of the Kerr-Newman Diagram. Unravelling the Interior of a Black Hole

Hector Gerardo Flores, Harshit Jain, Premachand Mahapatra, Maria Isabel Gonçalves de Souza

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: RLC electrical model; RC electrical model; cosmology; astronomy; astrophysics; background radiation; Hubble’ s law; Boltzmann´; s constant; dark energy; dark matter; black hole; Big Bang; cosmic inflation; early universe; quantum gravity; CERN; LHC; Fermilab; general relativity; particle physics; condensed matter physics; M theory; super string theory; extra dimensions; Penrose diagram, ccc conformal cyclic cosmology

Online: 2 August 2024 (12:13:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0346.v1

Automatic Fault Detection for Selective Laser Melting Using Semi-Supervised Machine Learning

Ikenna A. Okaro, Sarini Jayasinghe, Chris Sutcliffe, Kate Black, Paolo Paoletti, Peter L. Green

Subject: Engineering, Mechanical Engineering Keywords: SLM, Process Control, Semi-supervised Machine Learning, Randomised Singular Value Decomposition

Online: 18 September 2018 (11:21:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0432.v1

Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology

Elias Chappell, Laura Arbour, Zachary Laksman

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiovascular Epidemiology; Cardiogenetics; Underrepresented Populations; Diversity; Genetics; Genomics

Online: 5 January 2024 (02:10:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0346.v1

Artificial Populations in Agent-Based Modeling

Oksana Glushchenko, Aleksander Manolov, Ivan Kozlov, Vera Tsurkis, Irina Maslova, Nikolay Popov, Andrey Samoilov, Alexandr Lukashev, Elena Ilina

Subject: Biology And Life Sciences, Other Keywords: agen based modeling; COVID-19; digital epidemiology

Online: 6 December 2023 (12:34:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.1990.v1

Navigating the Evolving Landscape of COVID-19: Strategies to Increase Vaccine Confidence and Improve Vaccination Rates in the United States

James A. Mansi, Heather Hensler, Rachel Dawson, Reed Tuckson, Todd Wolynn

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19 vaccine; 2023-2024 COVID-19 vaccine; COVID-19 Vaccine confidence; Raising COVID-19 Vaccination Rates

Online: 30 May 2024 (12:04:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0495.v1

Effectiveness of a Group B outer Membrane Vesicle Meningococcal Vaccine in Preventing Hospitalization from Gonorrhea in New Zealand: a Retrospective Cohort Study

Janine Paynter, Felicity Goodyear-Smith, Jane Morgan, Peter Saxton, Steve Black, Helen Petousis-Harris

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Gonorrhea; Outer membrane vesicle vaccine; Group B meningococcus; Cohort study; New Zealand

Online: 29 June 2018 (16:29:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1231.v1

The L1014F Knockdown Resistance Mutation Is Not a Strong Correlate of Phenotypic Resistance to Pyrethroids in Florida Populations of Culex quinquefasciatus

Alden S Estep, Neil D Sanscrainte, Jason Stuck, Isik Unlu, Agne Prasauskas, Stephanie J Mundis, Nicholas Cotter, Ana L Romero-Weaver, Troy J Fedirko, Natalie L Kendziorski, Kyle J Kosinski, Daviela Ramirez, Eva A Buckner

Subject: Biology And Life Sciences, Insect Science Keywords: Culex quinquefasciatus; insecticide resistance; knockdown resistance (kdr); CDC bottle bioassay; Florida

Online: 23 February 2024 (06:26:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1419.v1

Use of Stable Isotopes (δ13C and δ15N) to Infer Post-breeding Dispersal Strategies in Iberian Populations of the Kentish Plover (Charadrius alexandrinus)

Andrea Gestoso, María Vidal, Jesús Domínguez

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Available habitat; Kentish plover; post-breeding dispersal; stable isotopes

Online: 25 March 2024 (08:47:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1754.v1

Potential of Using Entomopathogenic Fungi for Controlling Colorado Potato Beetle (Leptinotarsa decemlineata Say.) Populations Under Climate Change

Rauza Abdukerim, Meiramgul Mussina, Gaukartas Abysheva, Nagima Tumenbayeva, Bekzat Mombayeva, Assel Karabayeva, Nurgul Amangeldi, Zamzagul Amangeldikyzy

Subject: Biology And Life Sciences, Insect Science Keywords: Colorado potato beetle; climate change; biological plant protection; entomopathogenic fungi; virulence; thermotolerance; B. bassiana; B. pseudobassiana

Online: 23 September 2024 (10:52:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0961.v1

From Clastics to Carbonates and Black Shales: Deciphering Sedimentary Continuity and Discontinuity in the Devonian Landscape of the Volga-Ural Petroleum Province

Vladimir V. Silantiev, Dinara N. Miftakhutdinova, Nouria G. Nurgalieva

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Volga-Ural Petroleum Province, Devonian, black shales, carbonates, clastic, sedimentation, rate, environments

Online: 18 March 2024 (09:00:44 CET)

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Analyses of the three predominant types of sedimentation – clastic, carbonate and black shale – revealed their discontinuity/continuity in different facies environments of the Middle and Late Devonian of the central part of the Volga-Urals petroleum province, namely (1) in depressions, both condensed and non-condensed, (2) on the slopes of depressions and (3) in shallow water environments represented by tectonic arches or localised biohermal uplifts. The regional zonation of conodonts, correlated with the global chronostratigraphic scheme, substantiates the stratigraphic completeness of the general Devonian sequence in this area. In particular, the sedimentation of organic-rich black shales, traditionally considered as source rocks, lasted more than 29 million years, starting from the Late Eifel and ending at the Devonian-Carboniferous boundary. There was only one hiatus in the deposition of both black shales and carbonate sediments, lasting about 2.5 million years at the end of the Frasnian. That interval is dominated by clastic sediments, which are considered to be the most productive reservoirs of the Volga-Ural province. In the time interval from the beginning of the Eifel to the end of the Frasnian (about 17 Ma), (a) clastic sediments show the highest accumulation rates; (b) the most complete sequences occur in depressions; and (c) arches and uplifts show the most significant gaps in the geological record. During Famennian, (a) clastic sedimentation has completely ceased; (b) differences between the slopes of troughs and shallow-water environments have diminished, resulting in stable accumulation of carbonate sediments in both settings; (c) the decrease in sequence thickness (up to 50 m) in depressions suggests reduced accumulation rates of deep-water organic-rich black shales. The results help to understand the complex spatial relationship between different coexisting sedimentation types and focus attention to the incompleteness of the geological record in different environments.

Preprint ARTICLE | doi:10.20944/preprints202403.1563.v1

Comparative Studies of Bioactivities and Chemical Components in Fresh and Black Garlics

Kanako Matsuse, Sho Hirata, Mostafa Abdelrahman, Tetsuya Nakajima, Yoshihito Iuchi, Satoshi Kambayashi, Masaru Okuda, Kimiko Kazumura, Benya Manochai, Masayoshi Shigyo

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Allium sativum; black garlic; functional food; anticancer activity; processed food

Online: 26 March 2024 (11:33:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0647.v1

Bayesian networks in the management of hospital admissions: a comparison between explainable AI and black box AI during the pandemics.

Giovanna Nicora, Michele Catalano, Chandra Bortolotto, Marina Francesca Achilli, Gaia Messana, Antonio Lo Tito, Alessio Consonni, Sara Cutti, Federico Comotto, Giulia Maria Stella, Angelo Guido Corsico, Stefano Perlini, Riccardo Bellazzi, Raffaele Bruno, Lorenzo Preda

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: Artificial Intelligence; Explainability; Machine Learning; Random Forest; Bayesian Networks; COVID-19

Online: 11 March 2024 (16:54:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0056.v1

Experimental Investigation of Mechanical Properties of Black Shales after CO₂-Water-Rock Interaction

Qiao Lyu, P.G. Ranjith, Xinping Long, Bin Ji

Subject: Engineering, Civil Engineering Keywords: shale; CO2-water-rock interaction; mechanical properties; crack propagation; microstructure

Online: 5 August 2016 (12:35:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0391.v2

Origins of Stellar Mass Neutron Black Holes, Supermassive Dark Matter Black Holes and Universe Evolution

Jae-Kwang Hwang

Subject: Physical Sciences, Particle And Field Physics Keywords: Neutron black holes; dark matter black holes; black hole mass gap; universe evolution

Online: 18 March 2021 (10:52:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0096.v1

A Zeroth Law Compatible Model to Kerr Black Hole Thermodynamics

Viktor G. Czinner, Hideo Iguchi

Subject: Physical Sciences, Thermodynamics Keywords: black holes; entropy; nonextensive thermodynamics; stability

Online: 18 December 2016 (10:59:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1281.v1

Massive Black Holes

Eran Magshim Lavi

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Black hole; Massive black hole; maximum density; Dachus; absolute temperature; 0[K]

Online: 19 August 2024 (12:17:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1035.v1

Shannon Holes, Black Holes and Knowledge: Can a Machine become a “Self-Aware" Teammate?

William Lawless ---, And Ira S. Moskowitz

Subject: Computer Science And Mathematics, Robotics Keywords: debate; knowledge; entropy; interdependence; human-machine teammates; autonomy; complexity; embodied cognition; information; vulnerability

Online: 19 February 2024 (14:31:26 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1619.v1

A Rare Onset of T Lymphoid Blast Crisis in Chronic Myeloid Leukemia with Two Distinct Blast Populations

Alessandra Mongia, Francesca Romano, Sara Ciullini Mannurita, Benedetta Peruzzi, Sara Bencini, Daniela Parrini, Laura Fasano, Alessandra Fanelli

Subject: Medicine And Pharmacology, Hematology Keywords: chronic myeloid leukemia; T lymphoid blastic crisis

Online: 27 March 2024 (06:21:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1335.v1

Analysis of 2-Year Survival Outcome of Japanese Older Populations on Hemodiafiltration: A Propensity Score Matched Study Based on Insurance Claims Data

Aziz Jamal, Akira Babazono, Ning Liu, Takako Fujita, Sung-a Kim, Yunfei Li

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: hemodiafiltration; hemodialysis; all-cause mortality; survival outcome; insurance; Japan

Online: 19 August 2024 (13:13:41 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.0374.v1

Identifying Disparities and Promoting Environmental Justice for Vulnerable Populations in India

Vina Vaswani, Ifeanyichukwu Akuma

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Ecological backdrop; environmental justice; pollution's toll; human-nature nexus and generational burden

Online: 7 May 2024 (11:42:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1289.v1

Selective sweeps in the Austrian Turopolje and Other Commercial Pig Populations

Farzad Atrian-Afiani, Beate Berger, Christian Draxl Draxl, Johann Sölkner, Gábor Mészáros

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Selection Signatures; Genomic Analysis; Muscular Development Genes

Online: 19 October 2023 (16:42:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0144.v1

Characterization of Mutations Causing CYP21A2 Deficiency in Brazilian and Portuguese Populations

Mayara Jorgens Prado, Shripryia Singh, Rodrigo Ligabue-Braun, Bruna Meneghetti, Thaiane Rispoli, Cristiane Kopacek, Karina Monteiro, Arnaldo Zaha, Maria Rosa Rossetti, Amit V Pandey

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 21-hydroxylase deficiency; congenital adrenal hyperplasia; CYP21A2; functional characterization; Cytochrome P450

Online: 9 December 2021 (08:34:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0003.v1

Supersymmetry and Particle-Like Quantum Black Holes

Yuanxin Li

Subject: Physical Sciences, Theoretical Physics Keywords: quantum black holes; supersymmetry; mass

Online: 3 January 2024 (03:50:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0546.v1

Chemical Composition and Coloration Genesis of Black - Black Cyan Nephrite from Margou Deposit, Qiemo county, Xinjiang, China

Ting Fang, Mingxing Yang, Yuan Chang

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Nephrite; Chemical Composition; Coloration Genesis

Online: 9 February 2024 (10:52:27 CET)

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The nephrite belt in Altun Mountain-Western Kunlun Mountain region spanning approximately 1300 km in Xinjiang, NW China, constituting the world's largest preeminent nephrite deposit. The Qiemo region in the Altun Mountain is a crucial nephrite-producing area in China with demonstrating substantial prospects for future explorationl. While extant research has extensively study on secondary deposits in the Karakash River and native black nephrite deposits in Guangxi Dahua, a lacuna exists in the comprehensive investigation of black nephrite from original deposits in Xinjiang. Margou nephrite represents a recent discovery of black-toned nephrite deposits in Qiemo County, Xinjiang, warranting a comprehensive investigation into this primary source of black nephrite within the region. This scholarly inquiry deploys a suite of sophisticated analytical techniques, encompassing Polarizing microscope, electric microprobe, Backscattered Electron Image, X-ray Fluorescence, Inductively Coupled Plasma Mass Spectrometry. The rigorous experimental test is dedicated to elucidating the chemical and mineralogical composition, and further clarify the type of its genetic types of black-black cyan nephrite from Margou deposit in Qiemo, Xinjiang. Results delineate the mainly composed of tremolite-actinolite, characterized by Mg/(Mg + Fe2+) ratios ranging from 0.86 to 1.0. Minor minerals include diopside, epidote, pargasite, apatite, zircon, pyrite and iron hydroxide. Bulk-rock rare earth element patterns exhibit distinctive features such as negative Eu anomalies (δEu=0.00~0.17), decreasing light rare earth elements, a relatively flat distribution of heavy rare earth elements, and low with total REE concentrations (1.64~38.9 μg/g), concurrently, the Cr (6~21 μg/g) and Ni (2.5~4.5 μg/g) contents are conspicuously low. The magmatic influence of granite emerges as pivotal factor in the genesis of magnesia skarn hosting the Margou nephrite. The distinctive black-black cyan colour is attributed to heightened iron content, mainly associated with FeO (0.08~6.29%). The discerned chemical composition characteristics posit the Margou nephrite as an exemplar of the magnesia skarn-type nephrite deposit.

Working Paper ARTICLE

Brightest Point in Accretion Disk and Black Hole Spin: Implication to the Image of Black Hole M87*

Vyacheslav I. Dokuchaev, Natalia O. Nazarova

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: General Relativity, gravity, black hole, black hole shadow

Online: 18 June 2019 (10:31:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0169.v1

Black-Si as Photoelectrode

Denver Linklater, Fatima Haydous, Cheng Xi, Daniele Pergolesi, Jingwen Hu, Elena Ivanova, Saulius Juodkazis, Thomas Lippert, Jurga Juodkazyte

Subject: Chemistry And Materials Science, Electrochemistry Keywords: black Si; antireﬂection; photo-anode; water splitting9

Online: 10 April 2020 (07:51:31 CEST)

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Working Paper ARTICLE

Black Metals: Optical Absorbers

Stefan Lundgaard, Soon Hock Ng, Yoshiaki Nishijima, Michael Mazilu, Saulius Juodkazis

Subject: Physical Sciences, Optics And Photonics Keywords: metalmaterial; optical absorber; thin-film optics

Online: 11 February 2020 (09:26:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0236.v1

Black Hole Massive Thermodynamics

Arbab Arbab

Subject: Physical Sciences, Thermodynamics Keywords: Black holes thermodynamics; Entropic force; Electromagnetic-gravity analogy; General Relativity; Massive electrodynamics

Online: 13 August 2018 (17:09:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0978.v1

Epigenetics of genes preferentially expressed in dissimilar cell populations: Myoblasts and cerebellum

Melanie Ehrlich, Kenneth C. Ehrlich, Michelle Lacey, Carl Baribault, Sagnik Sen, Pierre Esteve, Sriharsa Pradhan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: myoblasts, cerebellum, epigenetics, WGBS, EM-seq, ZNF556, CHD15, TRIM72, DOK7, miR-486

Online: 13 December 2023 (10:42:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0920.v1

Effect of Nitrogen Levels on Methanogen and Methanotroph Populations in Rice Paddies

Youngho Kwon, So-Myeong Lee, Ju-Won Kang, Jin-Kyung Cha, Hyeonjin Park, Dong-Soo Park, Nkulu Rolly Kabange, Ki-Won Oh, Youn-Sig Kwak, Jong-Hee Lee

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: rice; methanogen; methanotroph; nitrogen fertilization

Online: 13 September 2023 (15:50:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1355.v1

Statuary Qualities of White and Black Göktepe Identified in the Hispanic Valdetorres De Jarama Marble Collection

M. Pilar Lapuente Mercadal, Trinidad Nogales-Basarrate

Subject: Arts And Humanities, Other Keywords: archaeometry; marble identification; marble quarry; Göktepe marble; Aphrodisian workshops; Late Antique Hispanic villae

Online: 17 July 2024 (04:53:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1275.v1

The Zoning Rule and Forming Mechanism of Tectonite-Mineralized Alteration Lithofacies of “Black/Fracture Zone” of the Daliangzi Pb-Zn Deposit in Southwest Sichuan of China

Lingjie Li, Runsheng Han, Jianbiao Wu, Zhixing Feng

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: “ black/fracture zone” ; ; tectonite-mineralized alteration lithofacies; strike-slip structure + diapirism (cryptoexplosion); Daliangzi Pb-Zn deposit; Sichuan-Yunnan-Guizhou Pb-Zn metallogenic province

Online: 22 March 2024 (03:28:20 CET)

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As one of the typical deposits in Sichuan-Yunnan-Guizhou Pb-Zn metallogenic province, the Daliangzi Pb-Zn deposit has a close genetic relation with the structural system of “black/fracture zone” formed under the action of NWW-approx. EW strike-slip structures in the metallogenic province, but the mechanism of rock and ore-controlling action of the structural system remains unclear. Based on detailed analysis of tectonite-mineralized alteration lithofacies of R1 “black/fracture zone”, the tectonite-mineralized alteration lithofacies zones can be divided into 4 types in succession outward from the Pb-Zn mineralization center, i.e., ① brecciated and stockwork-like Pb-Zn mineralization-complex breccia facies zone, ② stockwork-like Pb-Zn mineralization-simple breccia and cataclasite facies zone, ③ veined pyrite-sulfide-dolomitic cataclasite facies zone, and ④ fine-veined calcite-black carbonized dolomite facies zone; Cl- and SO42--rich high-temperature oxidizing ore-bearing fluid mixes with reducing fluid in Zone ① while migration and precipitation occur in Zone ④. With the evolution of ore-forming fluid, the homogenization temperature decreases from Zone ① to Zone ④, the salinity increases from Zone ① to Zone ② and then decreases to Zones ③ and ④, and the fluid density has little change on the whole; the contents of Zn, Pb, Cu, Ga, Ge, Cd, Ag, and other metallogenic elements, the Zn/Pb ratio, and the CaO/MgO mole ratio decrease gradually from Zone ① to Zone ④; and REE fractionation, calcilization, silicification, and pyritization enhance gradually from Zone ① to Zone ④. This series of changes are the product of diapirism (cryptoexplosion) of strike-slip structures and “black/fracture zone”, among which the second-order structures (F5, F100, and other faults) derived from NWW-approx. EW striking dextral shear-tension faults F1 and F15 control the brecciated and stockwork-like Pb-Zn mineralized complex breccia facies zones and the stockwork-like Pb-Zn mineralized simple breccia and cataclasite facies zones. Therefore, this paper establishes the zoning mode of tectonite-mineralized alteration lithofacies of “black/fracture zone” and proposes that Zones ① and ② are important prospecting criteria. conclusions.

Preprint ARTICLE | doi:10.20944/preprints202408.1435.v1

Unveiling Hidden Risks: Prenatal and Demographic Insights into Autism Spectrum Disorder

Aikaterini Sousamli, Elena Dragioti, Dimitra Metallinou, Aikaterini Lykeridou, Panagiota Dourou, Chrysoula Rozalia Athanasiadou, Dimitrios Anagnostopoulos, Antigoni Sarantaki

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: autistic spectrum disorders; functioning; prenatal risk factors; maternal age; age of diagnosis; vaginal bleeding; prenatal infections; family income; birth order; family history

Online: 20 August 2024 (13:46:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1501.v1

Glial Populations in the Human Brain Following Ischemic Injury

Victoria Mihailova, Irina I. Stoyanova, Anton B. Tonchev

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: glial cells; astrocytes; oligodendrocytes; NG2 glia; microglia; human brain; ischemic brain injury; transcription factors

Online: 21 July 2023 (10:28:46 CEST)

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There is a growing interest in glial cells in the central nervous system due to their important role in maintaining brain homeostasis both under physiological conditions and after injury. A significant amount of evidence has been accumulated regarding their capacity to exert either pro-inflammatory or anti-inflammatory effects under different pathological conditions. In combination with their known proliferative potential, they contribute not only to the limitation of brain damage and tissue remodeling but also to neuronal repair and synaptic recovery. Moreover, reactive glial cells can modulate the processes of neurogenesis, proliferation, and migration of neurons in the existing neural circuits in the adult brain. By discovering precise signals within specific niches, the regulation of sequential processes in adult neurogenesis holds the potential to unlock strategies that can stimulate the generation of functional neurons, whether in response to injury or as a means of addressing degenerative neurological conditions. Cerebral ischemic stroke, a condition falling within the realm of acute vascular disorders affecting the circulation of the brain, stands as a prominent global cause of disability and mortality. Extensive investigations into glial plasticity and their intricate interactions with other cells in the central nervous system have predominantly relied on studies conducted on experimental animals, including rodents and primates. However, valuable insights have also been gleaned from in vivo studies involving post-stroke patients, utilizing highly specialized imaging techniques. Following the attempts to map brain cells, the role of various transcription factors in modulating gene expression in response to cerebral ischemia is gaining increasing popularity. Although the results obtained thus far remain incomplete and occasionally ambiguous, they serve as a solid foundation for the development of strategies aimed at influencing the recovery process after ischemic brain injury.

Preprint ARTICLE | doi:10.20944/preprints202311.1978.v1

Entropy of Black Holes and an Oscillating Universe

Nick Gorkavyi

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: entropy; black holes; oscillating Universe

Online: 30 November 2023 (11:35:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0480.v1

Phytoplankton Dynamics and Biogeochemistry of the Black Sea

Vladimir Silkin, Larisa Pautova, Oleg Podymov, Valery Chasovnikov, Anna Lifanchuk, Aleksey Fedorov, Agnislava Kluchantseva

Subject: Environmental And Earth Sciences, Oceanography Keywords: phytoplankton; Black Sea; biogeochemistry; species composition; diatoms; coccolithophores

Online: 8 May 2023 (08:47:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0345.v1

Thermodynamics and Logarithmic Corrections of Symmergent Black Holes

Riasat Ali, Rimsha Babar, Zunaira Akhtar, Ali Övgün

Subject: Physical Sciences, Thermodynamics Keywords: Black hole; Symmergent gravity; Modified Lagrangian Equation; Hawking Radiation; Quantum Tunneling; WKB method. First order correction of thermodynamics

Online: 21 February 2023 (01:34:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1418.v1

Trends in Mercury Contamination Distribution among Human and Animal Populations in the Amazon

Irvin Martoredjo, Lenize Batista Calvão Santos, Jéssica Caroline Evangelista Vilhena, Alex Bruno Lobato Rodrigues, Andréia de Almeida, Carlos José Sousa Passos, Alexandro Cezar Florentino

Subject: Environmental And Earth Sciences, Pollution Keywords: Human Health Risks; Environmental Impact; Mining Impact; Spatial Distribution; Aquatic Ecosystems; Riverside Communities; Ecotoxicology; Ecoregion; Biosphere; Dietary Habits

Online: 26 February 2024 (11:56:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0042.v1

Demographic Performance of Helicoverpa zea Populations on Dual and Triple-Gene Bt Cotton

Marcelo M. Rabelo, Silvana V. Paula-Moraes, Eliseu Jose G. Pereira, Blair D. Siegfried

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: fitness; life table; cotton bollworm; corn earworm; toxin; resistance management

Online: 5 July 2020 (04:42:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0584.v1

Binary Black Hole Mirror Explosion

Aroonkumar Beesham

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Black holes; Gravitational waves; Binary system; Mirror images

Online: 8 August 2023 (13:54:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0487.v1

M87 Supermassive Black Hole Review

Mekhala Ganguly

Subject: Physical Sciences, Acoustics Keywords: black hole; supermassive black hole; black hole physics; M87 galaxies; gravitation; Event Horizon; telescope; observational astronomy

Online: 20 May 2021 (11:45:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1698.v1

Epidemiology of Chronic Hepatitis C in Indigenous Populations in Canada

Kate Dunn, Dennis Wardman, Maxim Trubnikov, Chris Sarin, Tom Wong, Hongqun Liu, Samuel S. Lee

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: hepatitis C; Indigenous health; First Nations; Inuit; Mé; tis; epidemiology; colonial trauma; prevalence; incidence; racism

Online: 25 August 2024 (06:36:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0956.v1

Immune Checkpoint Inhibitors in “Special” NSCLC Populations: A Viable Approach?

Giuseppe Bronte, Donato Michele Cosi, Chiara Magri, Antonio Frassoldati, Lucio Crinò, Luana Calabrò

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: NSCLC,; Immunotherapy; Immune Checkpoint Inhibitors; Special populations

Online: 13 June 2023 (16:01:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0296.v1

Linking Synthetic Populations to Household Geolocations: A Demonstration in Namibia

Dana R. Thomson, Lieke Kools, Warren C. Jochem

Subject: Social Sciences, Geography, Planning And Development Keywords: simulation; census; simpop; LMIC

Online: 19 June 2018 (11:13:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1268.v1

Assessing substrate degradation and bioconversion efficiency of black soldier fly (Hermetia illucens) larvae: effect of diet composition on growth and development temperature.

Simona Belperio, Arianna Cattaneo, Eleonora Nannoni, Luca Sardi, Giovanna Martelli, Sihem Dabbou, Marco Meneguz

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Black soldier fly, substrate, bioconversion, thermal imaging camera.

Online: 21 March 2024 (11:31:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0651.v1

Symmetry Transformations in Cosmological and Black Hole Analytical Solutions

Edgar Alejandro León, Andrés Sandoval-Rodríguez

Subject: Physical Sciences, Theoretical Physics Keywords: Analytical solutions; Black holes; Cosmology

Online: 11 March 2024 (18:10:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1638.v1

Black Soils in the Eastern Mediterranean: Genesis and Properties

Hussam Hag Husein, Rupert Bäumler, Bernhard Lucke, Wahib Sahwan

Subject: Environmental And Earth Sciences, Soil Science Keywords: semi-arid; black soils; Rendzina; Chernozems; eastern Mediterranean

Online: 21 December 2023 (09:35:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0049.v1

Dyonic and Magnetic Black Holes with Rational Nonlinear Electrodynamics

Sergey Kruglov

Subject: Physical Sciences, Mathematical Physics Keywords: nonlinear electrodynamics; black holes; heat capacity; free energy; phase transitions

Online: 5 January 2020 (17:27:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0680.v1

Symbiont Diversity in Imidacloprid-Resistant and Imidacloprid-Susceptible Populations of Nilaparvata lugens (Hemiptera: Delphacidae)

Juefeng Zhang, Fang Li, Haiying Zhong, Jianming Chen

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: imidacloprid; Nilaparvata lugens; PCR-DGGE; insecticide resistance; neonicotinoids

Online: 12 September 2023 (04:11:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1510.v1

Sensitivity of Eurasian Rear-Edge Birch Populations to Regional Climate and Local Hydrological Conditions

Ester González de Andrés, Michele Colangelo, Reyes Luelmo-Lautenschlaeger, José Antonio López-Sáez, Jesús Julio Camarero

Subject: Biology And Life Sciences, Forestry Keywords: Betula pendula; Betula pubescens; drought; growth decline; land use; peatland; Toledo Mountains

Online: 21 June 2023 (09:50:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1365.v1

Quantum correction to black hole accretion

Vyacheslav Ivanovich Dokuchaev

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: gravitation; astrophysics; black holes

Online: 19 December 2023 (09:37:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1874.v1

Relativistic Correction to Black Hole Entropy

Naman Kumar

Subject: Physical Sciences, Theoretical Physics Keywords: Kaniadakis statistics; Bekenstein-Hawking entropy; Microcanonical Entropy; Log correction

Online: 30 October 2023 (10:17:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0122.v1

The Black Hole Universe, part II

Enrique Gaztanaga

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Cosmology; Dark Energy; General Relativity; Black Holes

Online: 8 September 2022 (09:18:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0368.v2

Black Holes as Markers of Dimensionality

Szymon Łukaszyk

Subject: Physical Sciences, Mathematical Physics Keywords: quantum black holes; entropic gravity; the black hole information paradox; Shannon entropy; Delaunay triangulation; black hole quantum statistics; logistic function/map; exotic ℝ4

Online: 25 November 2021 (11:12:36 CET)

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Working Paper ARTICLE

Quantum Hair on Colliding Black Holes

Lawrence Crowell, Christian Corda

Subject: Physical Sciences, Quantum Science And Technology Keywords: quantum information; quantum hair; black hole quantum physics; quantum levels; AdS/CF T correspondence; Ryu-Takayanagi formula

Online: 1 August 2019 (04:06:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0441.v1

From Black Holes to Neutrino Stars

Roumen Tsekov

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: self-gravitation, black holes, neutrino stars

Online: 21 September 2018 (16:41:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0808.v1

Psychological distress in Low Income and Economically Marginalized (LIEM) populations in India: Protective and Risk factors.

Dipti Singh, Shagufta Nasir, Juhi Sharma, Lydia Giménez-Llort, Mohammad Ghazi Shahnawaz

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: mental health; low-income and economic marginalization (LIEM); socioeconomic status; urban slum; gender; caste; intersectionality

Online: 12 December 2023 (05:55:05 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202406.1276.v1

Exploring Study Abroad with Traditionally Underrepresented Populations: Impacts of Institutional Types

AKINDELE OGUNLEYE

Subject: Social Sciences, Education Keywords:
Study abroad; Underrepresented student; Academic credit; U.S. educational system; Ethnic/racial discrimination.

Online: 20 June 2024 (11:23:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1384.v1

Sequence characterization of eccDNA content in multiple blackgrass (Alopecurus myosuroides) populations

Wanfang Fu, Dana R MacGregor, David Comont, Christopher A Saski

Subject: Biology And Life Sciences, Plant Sciences Keywords: eccDNA; blackgrass; herbicide resistance; rapid adaptation

Online: 20 September 2023 (12:03:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0267.v2

Systematic Review of Wastewater Surveillance of Antimicrobial Resistance in Human Populations

Kevin Chau, Leanne Barker, Eric Budgell, Karina-doris Vihta, Natalie Sims, Barbara Kasprzyk-Hordern, Elinor Harriss, Derrick Crook, Daniel Read, Sarah Walker, Nicole Stoesser

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: AMR; sewage; epidemiology; wastewater; surveillance

Online: 21 June 2021 (11:25:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0111.v1

Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations

Jacqueline R. Halladay, Kaitlin C. Lenhart, Kimberly Robasky, Wendell Jones, Wayne F. Homan, Doyle M. Cummings, Crystal W. Cené, Alan L. Hinderliter, Cassandra L. Miller, Katrina E. Donahue, Beverly A. Garcia, Thomas C. Keyserling, Alice S. Ammerman, Cam Patterson, Darren A. DeWalt, Larry F. Johnston, Monte S. Willis, Jonathan C. Schisler

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: hypertension; GWAS; precision medicine; rural population; SNP-age interaction

Online: 12 January 2018 (07:34:37 CET)

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Background: As part of the Heart Healthy Lenoir Project, we developed a practice level intervention to improve blood pressure control. The goal of this study was: i) determine if single nucleotide polymorphisms (SNPs) that associate with blood pressure variation, identified in large case-control studies, are applicable to blood pressure control in subjects from a rural population; ii) measure the association of these SNPs with subjects’ responsiveness to the hypertension intervention; and iii) identify other SNPs that may help understand patient-specific responses to an intervention. Methods and Results: We used a combination of candidate SNPs and genome-wide analyses to test associations with either baseline systolic blood pressure (SBP) or change in systolic blood pressure one year after the intervention in two genetically defined ancestral groups: African Americans (AA) or Caucasian Americans (CAU). Of the 48 candidate SNPs, 13 SNPs associated with baseline SBP in our study; however, one candidate SNP, rs592582, also associated with a change in SBP after one year. Using our study data, we identified 4 and 15 additional loci that associated with a change in SBP in the AA and CAU groups, respectively. Our analysis of gene-age interactions identified genotypes associated with SBP improvement within different age groups of our populations. Moreover, our integrative analysis identified AQP4-AS1 and PADI2 as genes whose expression levels may contribute to the pleiotropy of complex traits involved in cardiovascular health and blood pressure regulation in response to an intervention targeting hypertension. Conclusions: Identification of SNPs associated with the success of a hypertension treatment intervention suggests that genetic factors in combination with age may contribute to an individual’s success in lowering SBP. If these findings prove to be applicable to other populations, the use of this genetic variation in making patient-specific interventions may help providers with making decisions to improve patient outcomes. Further investigation is required to determine the role of this genetic variance with respect to the management of hypertension such that more precise treatment recommendations may be made in the future as part of personalized medicine.

Preprint REVIEW | doi:10.20944/preprints201609.0029.v1

Fundamental Elucidation of HLA in Type 1 Diabetes of Arab Populations

Mohamed Mirza Jahromi

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: HLA; type 1 diabetes; ethnicity; screening; haplotype

Online: 7 September 2016 (12:49:02 CEST)

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Aims/Hypothesis): Type 1 diabetes is an immune-mediated disease with destruction of the pancreatic β-cells, a process that is conditioned by multiple genes and other factors. HLA counts as the major susceptibility gene. Significant variations in HLA genetic susceptibility to type 1 diabetes between Caucasians, African and Asian and other ethnic groups may have led to the variation in incidence of type 1 diabetes globally. Type 1 diabetes is characterized upon HLA identification. In this chapter we discuss global variations in genetic susceptibility of HLA with regard to type 1 diabetes globally with a particular attention to Arab population. Methods): Haplotype configuration of HLA class I A, B, C and Class II –DR/DQ/DP were studied in Caucasians, African and Asian and in Arab population to see if that is responsible for the exponential rise in the rate of type 1 diabetes. Results): Although Arabs have one of the highest global incidence and prevalence rates of type 1 diabetes, unfortunately, there is a dearth amount of information regarding HLA genetic susceptibility to type 1 diabetes in the Arab world. HLA haplotype configurations contribute to its risk value. However, out of an insufficient present study there are examples of misjudgment of HLA risk according to HLA alleles rather than haplotypes. Conclusion): To date HLA outlooks for the characterization of type 1 diabetes. There is an ethnicity difference in HLA characteristics which is responsible for variation in type 1 diabetes. Although Arab population have contributed heavily in the rise of burden of type 1 diabetes, however, there is significantly a dearth amount of studies on HLA in Arab population. Obviously, any future prediction, prevention or cure of the disease will be based on the HLA genetics. There is a dire need for a systematic screening of HLA for Arab population with type 1 diabetes, identification of Arab HLA-risk values and identify those who are prone to get the disease.

Preprint BRIEF REPORT | doi:10.20944/preprints202306.2051.v1

Genetic Structure and Biodiversity in Wild Centropomus Parallelus and in Wild and Recently Domesticated Centropomus Undecimallis Populations

Marcos Edgar Herkenhoff, Miklos Maximiliano Bajay, Carlos André da Veiga Lima-Rosa Costamilan

Subject: Biology And Life Sciences, Aquatic Science Keywords: Microsatellites; Centropomus parallelus; Centropomus undecimalis; Centropomidae, genetic polymorphism

Online: 28 June 2023 (15:31:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1221.v1

Aiming for Equity: Addressing COVID-19 Vaccine Hesitancy among American Indian/Alaska Native Populations through Educational Interventions

Maya Asami Takagi, Simone T Rhodes, Jun Hwan Kim, Maxwell King, Stephanie Sokar, Chad Martin, Angela Sasaki Cole, Arlene Chan, Ciara Brennan, Stephen Zyzanski, Barry Kissoondial, Neli Ragina

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19 vaccine hesitancy; American Indian/Alaska native populations; educational interventions; health disparities; health equity; Indian Health Service; Culturally Relevant Interventions; Policy Advocacy

Online: 18 June 2024 (11:20:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0339.v1

Maximal Mass Within Sphere,Repulsion,Black Holes and Some Implications

Alexander Shalyt-Margolin

Subject: Physical Sciences, Space Science Keywords: maximal mass principle; black holes; repulsion; cosmology

Online: 6 December 2023 (07:17:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0350.v1

Black Hole Entropy from Non-Dirichlet Sectors, and Bounce Solution

Inyong Park

Subject: Physical Sciences, Acoustics Keywords: black hole entropy; non-Dirichlet boundary condition; bounce

Online: 23 September 2022 (02:06:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0273.v1

Bounding Greybody and Deflection Angle of Improved Schwarzschild Black Hole

Wajiha Javed, Muhammad Aqib, Ali Övgün

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: General Relativity; Improved Schwarzschild Black hole; Plasma medium; Gauss-Bonnet theorem; Non plasma medium; Hawking radiation; Greybody Factor.

Online: 15 November 2021 (19:36:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0051.v2

Weak Deflection Angle and Shadow by Tidal Charged Black Hole

Wajiha Javed, Ali Hamza, Ali Övgün

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: Relativity; Gravitation; Black hole; Tidal Charge; Gauss-bonnet theorem; plasma medium; Shadow

Online: 19 October 2021 (10:13:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0096.v1

Black Hole Entropy from Non-Commutative Geometry and Spontaneous Localisation

Tejinder P. Singh, Palemkota Maithresh

Subject: Physical Sciences, Quantum Science And Technology Keywords: black hole entropy; quantum gravity; non-commutative geometry; spontaneous localisation; trace dynamics

Online: 8 November 2019 (10:54:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0149.v1

Gender and Race in Ministry Leadership: Experiences of Black Clergywomen

Dr. Kimberly Nelms Smarr, PsyD, Dr. Rachelle Disbennett-Lee, PhD, Dr. Amy Cooper Hakim, PhD

Subject: Arts And Humanities, Religious Studies Keywords: Leadership, Women, Women Clergy, Black, Religion and Gender.

Online: 8 October 2018 (13:57:05 CEST)

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