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Preprint REVIEW | doi:10.20944/preprints202310.1240.v1

Advancements in Treatment Strategies for Chronic Mesenteric Ischemia: A Comprehensive Review

Genti Xhepa, Andrea Vanzulli, Lucilla Violetta Sciacqua, Agostino Inzerillo, Pierre Faerber, Anna Maria Ierardi, Gianpaolo Carrafiello, Filippo Del Grande, Alexis Ricoeur

Subject: Medicine And Pharmacology, Surgery Keywords: review; chronic mesenteric ischemia; superior mesenteric artery; revascularization; treatment; endovascular revascularization (ER); percutaneous transluminal angioplasty (PTA); primary stenting (PMAS)

Online: 19 October 2023 (10:14:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0860.v1

Diagnostic Role of MDCT in Acute Mesenteric Ischemia

Francesco Michele Ronza, Teresa Letizia Di Gennaro, Gianfranco Buzzo, Luciana Piccolo, Marina Della Noce, Giovanni Giordano, Giuseppe Posillico, Francesco Giuseppe Mazzei, Paolo Ricci, Salvatore Masala, Mariano Scaglione, Stefania Tamburrini

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: acute mesenteric ischemia; MDCT; atherosclerosis; embolism; dissection; NOMI; mesenteric thrombosis

Online: 13 May 2024 (14:31:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0384.v1

Prospects of Intraoperative Multimodal OCT Application in Patients With Acute Mesenteric Ischemia

Elena Kiseleva, Maxim Ryabkov, Mikhail Baleev, Evgeniya Bederina, Pavel Shilyagin, Vladimir Beschastnov, Ivan Romanov, Grigory Gelikonov, Natalia Gladkova

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: acute mesenteric ischemia (AMI); optical coherence tomography (OCT); optical coherence angiography (OCA); intraoperative diagnostics; gut vitality; image assessment

Online: 17 February 2021 (12:02:23 CET)

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Introduction: Despite the introduction of increasingly multifaceted diagnostic techniques and the general progress of emergency abdominal and vascular surgery, the outcome of treatment of patients with acute impaired intestinal circulation remains unsatisfactory. The non-invasive and high-resolution technique of optical coherence tomography (OCT) can be used intraoperatively to assess intestine viability and associated conditions that frequently emerge under conditions of impaired blood circulation. This study aims to demonstrate the effectiveness of multimodal (MM) OCT for intraoperative diagnostics of both the microstructure (cross-polarization OCT mode) and microcirculation (OCT angiography mode) of the small intestine wall in patients with acute mesenteric ischemia (AMI). Methods and Participants: A total of 18 patients were enrolled in the study. Nine of them suffered from AMI in segments II-III of the superior mesenteric artery (AMI group), where the ischemic segments of the intestine were examined. Nine others were operated for adenocarcinoma of the colon (control group), thus allowing areas of their normal small intestine to be examined for comparison. Data on the microstructure and microcirculation in the walls of the small intestine were obtained intraoperatively from the side of the serous membrane using the MM OCT system (IAP RAS, Russia) before bowel resection. The MM OCT data were compared with the results of histological examination. Results: The study finds that MM OCT visualized the damage to serosa, muscularis externa, and blood vessels localized in these layers in 100% of AMI cases. It also visualized the submucosa in 33.3% of AMI cases. The MM OCT image of non-ischemic (control group), viable ischemic and necrotic small intestines (AMI group) differed significantly across stratification of the distinguishable layers, the severity of intermuscular fluid accumulations and the type and density of the vasculature. Conclusion: The MM OCT diagnostic procedure optimally meets the requirements of emergency surgery. Data on the microstructure and microcirculation of the intestinal wall can be obtained simultaneously in real time without requiring contrast agent injections. The depth of visualization of the intestinal wall from the side of the serous membrane is sufficient to assess the volume of the affected tissues. However, the methodology for obtaining MM OCT data needs to be improved to minimize the motion artefacts generated in actual clinical conditions.

Preprint ARTICLE | doi:10.20944/preprints202409.1723.v1

Effectiveness of Three Front-of-Pack Food Labels in Guiding Consumer Identification of Nutrients of Concern and Purchase Intentions in Kenya: A Randomized Controlled Trial

Shukri F Mohamed, Caroline H Karugu, Samuel Iddi, Veronica Ojiambo, Caliph Kirui, Gershim Asiki

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: front-of-pack-labels (FOPL); warning labels (WL); packaged foods; salt; sugar; saturated fats; fat; randomized controlled trial (RCT); Kenya ;

Online: 23 September 2024 (12:00:17 CEST)

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Background: Front-of-pack-labels (FOPLs) on packaged foods provide consumers with essential information about the nutritional content of food products, enabling them to make informed choices and align their dietary habits with their health goals. However, evidence on the comprehensibility, use, and effectiveness of FOPLs remains limited, particularly in low- and middle-income countries like Kenya. Objective: In this study, we assessed the effectiveness of three FOPLs in helping consumers identify excess nutrients of concern in packaged food products and their potential influence on food purchases in Kenya. Methods: A total of 2198 shoppers with diverse backgrounds were recruited from selected supermarkets in three Kenyan main cities (Nairobi, Mombasa, Kisumu) and a small town (Garissa). Participants were randomized to three FOPLs: Red and green Octagon label (RG), Red and Green Octagon with icons (RGI) and a black Octagon Warning label (WL). In the control phase, participants were shown unlabeled images of packaged food products and they responded to a set of questions. In the experimental phase, the same product images were presented with one of the three front-of-pack labels they were randomized to, and participants answered the same questions again. Differences in the proportions of participants correctly identifying the nutrients of concern and the changes in intention to purchase unhealthy foods before and after exposure to FOPLs were analyzed using frequency tables and Chi-Square tests. The effectiveness of the three FOPLs was further assessed using a modified Poisson regression. Results: Results showed that exposure to FOPLs significantly improvement participants' ability to correctly identify nutrients of concern across various food categories. Additionally, FOPLs reduced consumers’ intentions to purchase unhealthy foods, with the Warning Labels (WL) emerging as particularly effective in enhancing consumers' understanding of product healthiness and reducing the intention to purchase unhealthy foods compared to the other two FOPLs. Conclusion: These findings underscore the potential role of FOPLs, particularly the WL as an effective regulatory tool for promoting healthier food choices in Kenya.

Preprint CASE REPORT | doi:10.20944/preprints202401.1796.v1

Retrograde Endovascular Recanalization of the Superior Mesenteric Artery for the Treatment of Acute Bowel Ischemia: Case Report

Pawel Latacz, Piotr Piekorz, Marian Simka

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: acute bowel ischemia; mesenteric artery occlusion; mesenteric artery stenting; retrograde

Online: 25 January 2024 (07:12:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.1664.v1

Limb Salvage and Survival in Chronic Limb-Threatening Ischemia: The Need for Fast-Track Team-Based Approach

Giorgio Ventoruzzo, Giulia Mazzitelli, Umberto Ruzzi, Francesco Liistro, Alessia Scatena, Eugenio Martelli

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: peripheral arterial disease; critical limb ischemia; chronic limb-threatening ischemia; survival; mortality; limb salvage

Online: 25 August 2023 (02:41:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0863.v1

Isolated Femoral Bifurcation Endarterectomy or Combined with Bypass Surgery in Patients with Chronic Limb Threatening Ischemia

Edin Ahmic, Wolfgang Hitzl, Rainald Seitelberger, Klaus Linni

Subject: Medicine And Pharmacology, Surgery Keywords: endarterectomy; bypass surgery; femoral artery; lesion

Online: 11 January 2024 (09:04:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1715.v1

Percutaneous Deep Venous Arterialization for Limb Salvage of No Option Patients with Chronic Limb-Threatening Ischemia

Stavros Spiliopoulos, Efstathia Davoutis, Nikolaos-Achilleas Arkoudis, Kaji Sritharan, Symeon Lechareas

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic limb-threatening ischemia; peripheral arterial disease; endovascular treatment; tibial vessels; percutaneous deep venous arterialization

Online: 26 September 2023 (04:44:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0570.v1

Mir-21 Regulates Growth and Migration of Cervical Cancer Cells by RECK Signaling Pathway

Seidy Y. Aguilar-Martínez, Gabriela E. Campos-Viguri, Selma E. Medina-García, Ricardo J. García-Flores, Jessica Deas, Claudia Gómez-Cerón, Abraham Pedroza-Torres, Elizabeth Bautista-Rodríguez, Gloria Fernández-Tilapa, Mauricio Rodríguez-Dorantes, Carlos Pérez-Plasencia, Oscar Peralta-Zaragoza

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cervical cancer; microRNAs; miR-21; RECK; siRNAs

Online: 9 February 2024 (11:20:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0205.v1

Different Lower Extremity Arterial Calcification Patterns in Patients with Chronic Limb-Threatening Ischemia Compared with Asymptomatic Controls

Louise CD Konijn, Richard AP Takx, Willem PThM Mali, Hugo TC Veger, Hendrik van Overhagen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic limb-threatening ischemia; peripheral arterial disease; calcification pattern

Online: 7 April 2021 (14:45:17 CEST)

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Objectives The most severe type of peripheral arterial disease (PAD) is critical limb ischaemia (CLI). In CLI, calcification of the vessel wall plays an important role in symptoms, amputation rate and mortality. However, calcified arteries are also found in asymptomatic persons (non-PAD patients). We investigated whether the calcification pattern in CLI patients and non- PAD patients are different and could possibly explain the symptoms in CLI patients. Materials and Methods 130 CLI and 204 non-PAD patients underwent a CT of the lower extremities. This resulted in 118 CLI patients (mean age 72±12, 70.3% male) that were age-matched with 118 non-PAD patients (mean age 71±11, 51.7% male). The characteristics severity, annularity, thickness and continuity were assessed in the femoral and crural arteries and analysed by binary multiple logistic regression. Results Nearly all CLI patients have calcifications and these are equally frequent in the femoropopliteal (98.3%) and crural arteries (97.5%), while the non-PAD patients had in just 67% any calcifications with more calcifications in the femoropopliteal (70.3%) than in the crural arteries (55.9%, p<0.005). The crural arteries of the CLI patients had significantly more complete annular calcifications (OR 2.92, p=0.001.) while in the non-PAD patients dot-like calcifications dominated. In CLI patients, the femoropopliteal arteries had more severe, irregular / patchy and thick calcifications (OR 2.40, 3.27, 1.81, p≤0.05, respectively) while in non-PAD patients, thin continuous calcifications prevailed. Conclusions Compared with non-PAD patients CLI patients are more frequently and extensively calcified. Annular calcifications were found in the crural arteries of CLI patients while dot-like calcifications were mostly present in the non-PAD patients. These different patterns of calcifications in CLI point at different etiology and can have prognostic and eventually therapeutic consequences.

Preprint CASE REPORT | doi:10.20944/preprints202006.0282.v1

Case Report – Inferior Mesenteric Vein Thrombosis and COVID-19

Aureo do Carmo Filho, Bruno da Silva Cunha

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; mesenteric vein thrombosis

Online: 21 June 2020 (16:44:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0243.v1

Generation of an Alzheimer’s Disease Model Derived from Induced Pluripotent Stem Cells with an APP Gene Mutation

Yena Kim, Binna Yun, Byoung Seok Ye, Bo-Young Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s disease; amyloid precursor protein; cerebral organoid; disease modeling; drug screening; induced pluripotent stem cells; organoids; tau pathology

Online: 6 May 2024 (07:37:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0794.v1

A New Organ: The Mesentery and Non-Vascular Mesenteric Diseases

Monjur Ahmed

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: mesentery; mesenteropathy; mesenteric adenitis; mesenteric panniculitis; mesenteric adiposity; mesenteric neoplasms

Online: 10 January 2024 (08:23:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0935.v1

Advancing Hepatitis C Elimination in Africa: Insights from Egypt

IZERE Salomon, Sibomana Olivier, Ndayambaje Egide

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Hepatitis C; Elimination; Africa; Egypt; Direct-acting antivirals; Policy insights; Hepatitis virus

Online: 15 March 2024 (14:40:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0999.v1

Assessing the Feasibility of Handheld Cameras to Increase Access to Teleretinal Diabetic Retinopathy Screenings in Safety-Net Clinics in Los Angeles

Gabrielle Green, Roxana Flores, Elvia Figueroa, Tony Kuo, Lauren Daskivich

Subject: Public Health And Healthcare, Primary Health Care Keywords: Teleretinal diabetic retinopathy screenings; handheld cameras; safety-net; diabetes; feasibility

Online: 12 September 2024 (16:01:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1456.v1

The Effect of “Proanthocyanidin” on Ischemia-Reperfusion Injury in Skeletal Muscles of Rats

Abdullah Özer, Başak Koçak, Şaban Cem Sezen, Mustafa Arslan, Mustafa Kavutçu

Subject: Medicine And Pharmacology, Surgery Keywords: Ischemia reperfusion; proanthocyanidin; lower extremity; rat; TBARS

Online: 25 March 2024 (08:53:48 CET)

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BACKGROUND: Lower limb skeletal muscle ischemia-reperfusion (IR) injury associated with increased morbidity and mortality is common in several clinical situations such as aortic aneurysms repairment, peripheral arterial surgery, vascular injury repairment, and shock. Although it is generally accepted that oxidative stress mediators have a significant role in IR injury, its precise mechanism is still unknown. Anecdotally, it is sustained not only by structural and functional changes in the organ it affects but also by damage to distant organs. The purpose of this report is to illustrate the effect of proanthocyanidin on IR injury. METHODS: In our study, 18 male Wistar albino rats were used. The subjects were divided into three groups of six each. (Group Control-C, Group Ischemia-Reperfusion -IR, Group Ischemia-Reperfusion and Proanthocyanidin-IR-PRO). Intraperitoneal proanthocyanidin was given to the IR and proanthocyanidin groups 30 minutes before laparotomy and 1-hour ischemia led to these two groups. After one hour, reperfusion started. Muscle atrophy-hypertrophy, muscle degeneration-congestion, fragmentation-hyalinization, muscle oval-central nucleus ratio, leukocyte cell infiltration, catalase enzyme activity, and TBARS were all examined in lower-limb muscle samples after one hour of reperfusion. RESULTS: When skeletal muscle samples were evaluated histopathologically, it was discovered that muscle atrophy-hypertrophy, muscle degeneration-congestion, fragmentation-hyalinization, and leukocyte cell infiltration with oval-central nucleus standardization were significantly higher in the IR group than group control and group IR-proanthocyanidin. Besides, oval-central nucleus standardization was significantly higher in the IR and proanthocyanidin group than in the control group. TBARS levels were significantly higher in the IR group than in the control and IR-proanthocyanidin groups while, catalase enzyme activity was found to be significantly lower in the IR group than in the control and IR and proanthocyanidin groups. CONCLUSION: As a consequence of our research, we discovered that proanthocyanidins administered before IR have a protective impact on skeletal muscle in rats. Further research in this area is required.

Preprint REVIEW | doi:10.20944/preprints202401.0605.v1

Superior Mesenteric Artery Syndrome Results From Hypersecretion of Hydrochloric Acid

Michael Levin

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Duodenal physiology; superior mesenteric artery syndrome; Ochsner's sphincter dyskinesia; hydrochloric acid hypersecretion; pathophysiology

Online: 8 January 2024 (09:41:28 CET)

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It is currently believed that the cause of superior mesenteric artery syndrome (SMAS) is compression of the duodenum in the angle between the aorta and superior mesenteric artery (SMA). It is recognized that a decrease in aortomesenteric angle (AMA) <25° and intervascular distance < 8 mm, caused by fat loss, is characteristic of SMAS. Based on these statements, surgeons operate on patients with symptoms of dyspepsia only based on a reduction of AMA. This study is devoted to the analysis of the literature, including four own studies on this issue. Results: Measurement of the length of the constriction in the third part of the duodenum on radiograms from available sources showed that its true length ranged from 2.5 to 4.2 (3.30±0.15) cm and began a few centimeters cranial to the AMA. Therefore, it could not have been caused by compression in the AMA. In terms of length (3.20±0.15 cm) and location, this constriction corresponded to Ochsner’s sphincter, which normally short-term contracts to prevent the penetration of an acid bolus into the jejunum. Conscientious studies have shown that AMA is proportional to BMI, i.e., a decrease in AMA is observed in all thin people. An analysis of 211 cases of SMAS made it possible to differentiate two types of diseases. In 101 patients, the disease occurred acutely 1–53 (8.2 ± 1.9) days after stressful situations, accompanied by a catabolic reaction and hypersecretion of hydrochloric acid. In 110 patients, SMAS developed 3-72 (17.2±3.2) months after the diagnosis of acid-dependent diseases. Conclusion: The analysis of the literature led to the conclusion that hypersecretion of hydrochloric acid causes damage to the upper level of the digestive system, including duodenal dyskinesia. One of the manifestations of duodenal dyskinesia is an increase in tone and hypertrophy of the Ochsner’s sphincter. The clinic of the disease depends on the varying degree of Ochsner’s sphincter dyskinesia. In severe cases, partial or complete intestinal obstruction. New ideas about the etiology and pathogenesis of the so-called SMAS have made it possible to propose a tactic for the diagnosis and treatment of Ochsner’s sphincter dyskinesia, where there is no place for surgical treatment.

Preprint CASE REPORT | doi:10.20944/preprints202311.1336.v1

Pneumatosis Intestinalis Concurrent with Superior Mesenteric Artery Thrombosis: A Case Report

Parihar Doshi, Tushar Teraiya, Vismit Gami, Sahil Shah, Dev Desai

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Pneumatosis intestinalis; Thrombosis; CT Scan; Atherosclerosis; Ischemia

Online: 21 November 2023 (13:43:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0945.v1

The Effect of Cerium Oxide (CeO2) on Ischemia-Reperfusion Injury in Skeletal Muscle in Mice with Streptozocin-Induced Diabetes

Abdullah Özer, Necmiye Şengel, Ayşegül Küçük, Zeynep Yığman, Çağrı Özdemir, Yiğit Kılıç, Ali Doğan Dursun, Hasan Bostancı, Gülay Kip, Mustafa Arslan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: diabetes mellitus; cerium oxide; skeletal muscle; lower limb; ischemia-reperfusion

Online: 19 February 2024 (14:12:37 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202311.0312.v1

Isolated Intramural Hematoma of Superior Mesenteric Artery: Case Reports and a Review of Literature

Marta Ascione, Rocco Cangiano, Alireza Mohseni, Andrea Molinari, Antonio Marzano, Alessia Di Girolamo, Luca Di Marzo, Wassim Mansour

Subject: Medicine And Pharmacology, Other Keywords: intramural hematoma; superior mesenteric artery; treatment; steroid

Online: 6 November 2023 (13:42:55 CET)

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(1) Background: Spontaneous isolated intramural hematoma of the superior mesenteric artery (SIHSMA) is a rare entity often considered as a subset of spontaneous isolated dissection of the superior mesenteric artery (SIDSMA). It is characterized by a completely thrombosed false lumen with or without ulcer-like projection with computed tomography (CT) imaging. The recent literature describes few reports with a relatively short-term follow-up. The natural course, prognosis, and treatment options for SIHSMA still lack consensus. We present two cases of acute abdominal pain in a young man due to IMH of the superior mesenteric artery with an extensive literature review. (2) Case report: A 46-year-old male patient was submitted to an urgent CTA for acute abdominal pain, showing the presence of an isolated dissection of the superior mesenteric artery, determining significant stenosis of the vessel with collateral vessel patency. The patient referred to a recent COVID-19 infection, whose course was paucisymptomatic. He was treated conservatively with antiplatelet therapy and corticosteroid treatments, and, after a few days, the symptomatology completely regressed; also, 2-month- control CTA showed the complete IMH regression and the absence of any signs of residual stenosis. The second patient is a 61-year-old male patient who was submitted to an urgent CTA for acute abdominal pain, showing the presence of an isolated dissection of the superior mesenteric artery, not determining significant vessel stenosis. He was treated conservatively with antiplatelet therapy and corticosteroid treatment, and after a few days, the symptomatology completely regressed, and the radiological control showed a complete dissection regression. (3) Conclusion: SISHSMA is a rare entity of vascular pathology, and conservative management represents the best medical strategy. We propose corticosteroid treatment as one of the most appropriate tools in the conservative treatment of SISHSMA.

Preprint ARTICLE | doi:10.20944/preprints202405.1896.v1

The Effect of Silymarin on Ischemia-Reperfusion Injury in Skeletal Muscles of Rats

Abdullah Özer, Başak Koçak, Mustafa Arslan, Barış Mardin, Ayşegül Küçük, Şaban Cem Sezen, Mustafa Hakan Zor, Mustafa Kavutçu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: silymarin; malondialdehyde; catalase; ischemia-reperfusion

Online: 29 May 2024 (07:22:24 CEST)

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Background and Aim: It is generally accepted that oxidative stress mediators play an important role in ischemia-reperfusion injury(I/R), although the exact mechanism is not fully elucidated. While the impact of silymarin on I/R injury in several tissues, including the myocardial, cerebral, gastric and liver tissue, has been examined, the present state of research on this topic remains insufficient to provide a widely accepted understanding. For this purpose, our objective was to examine the effect of silymarin on muscle tissue in rats subjected to lower extremity I/R injury. Method: After ethics committee approval, 18 male Wistar albino rats weighing between 225-275 g were used. The rats were divided into three groups containing six mice each, Control,Ischemia-Reperfusion and Silymarin-Ischemia/Reperfusion groups. Silymarin was administered intraperitoneally 30 minutes before the procedure.( 100 mg/kg-1 ) In the I/R groups, an atraumatic microvascular clamp was placed in the infrarenal abdominal aorta. After 120 minutes, the clamp was removed and reperfusion was achieved for 120 minutes. In muscle tissue samples taken at the end of the reperfusion period; Malondialdehyde (MDA) levels, catalase (CAT) enzyme activity levels and histopathological parameters were compared. Results: In the histopathological examination, no degeneration was observed in the muscle fibers in the control group, while findings of striated muscle damage such as muscle atrophy hypertrophy, muscle degeneration-congestion, internal of the muscle nucleus-oval-central nucleus, fragmentation-hyalinization and leukocyte cell infiltration were observed in the I/R group. In the S-I/R group, muscle atrophy hypertrophy, internal of the muscle nucleus-oval-central nucleus, fragmentation-hyalinization and leukocyte cell infiltration were observed to improve these damaged areas compared to the I/R group. MDA levels in the I/R group were found to be significantly higher than in the control and S-I/R groups. CAT enzyme activity was found to be significantly higher in the I/R group than in the control group. Conclusion:Our study revealed that the administration of silymarin at a dosage of 100 mg/kg-1 by intraperitoneal injection 30 minutes before ischemia in rats effectively decreased lipid peroxidation and oxidative stress. Additionally, it successfully reduced the injury caused by ischemia/reperfusion in muscle histology.

Preprint REVIEW | doi:10.20944/preprints202306.0567.v1

Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis

Leonid L Bershtein, Alexey Sumin, Elizaveta Zbyshevskaya, Victoria Gumerova, Darejan Tsurtsumia, Igor Kochanov, Alina Andreeva, Vartan Piltakian, Sergey Sayganov

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic coronary syndromes; revascularization; prognosis; ISCHEMIA; ISCHEMIA-EXTEND

Online: 8 June 2023 (02:13:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1153.v1

Needs-Assessment for an Artificial Intelligence-based Chatbot for Pharmacists in HIV Care: Results from a Knowledge-Attitudes-Practices Survey

Moustafa Laymouna, Yuanchao Ma, David Lessard, Kim Engler, Rachel Therrien, Tibor Schuster, Serge Vicente, Sofiane Achiche, Maria Nait El Haj, Benoit Lemire, Abdalwahab Kawaiah, Bertrand Lebouché

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: pharmacists; HIV; chatbot; artificial intelligence; needs assessment; surveys and questionnaires; health information technology; healthcare provider; health knowledge-attitudes-practices; patient care

Online: 16 August 2024 (03:27:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1862.v1

Evaluation of Chronic Pain Development in Patients Undergoing Shoulder Arthroscopy

Teoman Etikcan, Keziban Sanem Cakar Turhan, Suheyla Karadag Erkoc, Hanzade Aybuke Unal

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; postoperative pain; arthroscopy

Online: 24 September 2024 (11:04:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0777.v1

Impact of Pelvic Fracture on Patients With Blunt Bowel Mesenteric Injury: A Retrospective Analysis

Ting-Min Hsieh, Po-Chun Chuang, Chun-Ting Liu, Bei-Yu Wu, Chien-Hung Wu, Fu-Jen Cheng

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: blunt abdominal trauma; blunt bowel mesenteric injuries; pelvic fracture; emergency department; laparotomy

Online: 13 November 2023 (08:46:06 CET)

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The management of blunt abdominopelvic trauma with combined hemoperitoneum and pelvic fractures is challenging for trauma surgeons. Although angioembolization can achieve hemostasis in most visceral organ injuries and pelvic fractures after blunt abdominal trauma, it cannot effectively control hemorrhage in patients with blunt bowel mesenteric injury (BBMI). This study aimed to determine the risk factors associated with hemodynamically unstable patients with BBMI and to test the hypothesis that pelvic fracture is an independent risk factor for patients with unstable BBMI and concomitant pelvic fracture to guide the therapeutic sequence for difficult-to-manage patients. This retrospective study reviewed the data of hospitalized patients with trauma between 2009 and 2021 and included 158 adult patients with surgically proven BBMI. The patients were divided on the basis of the presence of a shock episode before emergency laparotomy. The shock group included 44.3% of all patients in the study (n = 70). Clinical injury severity and prognosis for patients in the shock group were poorer than those for patients in the non-shock group, and more invasive treatments and transfusions were performed for patients in the shock group than for those in the non-shock group. Pelvic fractures were more frequently associated in the shock group than in the non-shock group (21.4% vs. 5.7%; p = 0.003). In multivariate analysis, the presence of intracerebral hemorrhage (odds ratio [OR] = 10.87, 95% confidence intervals [CIs]: 1.70–69.75) and rib fracture (OR = 5.94, 95% CIs = 1.06–33.45) were identified as independent predictors of shock, whereas the effect of pelvic fracture did not achieve statistical significance (OR = 2.94, 95% CIs = 0.66–13.13) after adjusting for confounding factors. For patients with BBMI, outcomes need to be improved during early diagnosis and treatments should be expeditiously performed on the basis of the rapid identification of unstable hemodynamic status. In unstable patients with concomitant pelvic fractures, we support the current management algorithm that recommends performing laparotomy first.

Preprint ARTICLE | doi:10.20944/preprints202403.0059.v1

Olfactory Rehabilitation for Chronic Pain: A Multi-Dimensional Approach Supported by fMRI Insights

Mariaconsiglia Santantonio, Carmela Riso, Simona Gaudino, Alessio Simonetti, Giuseppe Varcasia, Francesco Schimperna, Bruno Sergi, Eugenio De Corso, Marco Rossi, Jacopo Galli, Marco De Spirito, Giuseppe Maulucci, Giulio Cesare Passali

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: olfactory rehabilitation; chronic pain; fMRI

Online: 1 March 2024 (18:18:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1519.v1

Control Group in Foot Plantar Pressure Studies – Does Chronic Low Back Pain Matter?

Barbara Jasiewicz, Ewa Klimiec, Piotr Guzdek, Grzegorz Kołaszczyński, Krzysztof Zaraska, Slawomir Duda, Jacek Lorkowski, Tomasz Potaczek

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: foot; gait; low back pain

Online: 19 July 2024 (07:53:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0082.v1

Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury

Jin Yu, Hong Zhu, Mark Kindy, Saeid Taheri

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Oxidative stress; CYP2E1; Ischemia/reperfusion; Inflammation; Blood-brain barrier

Online: 3 December 2020 (11:05:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0301.v1

Acute Heart Failure, 90-day Mortality—and Gravitational Ischemia in the Brain

J. Howard Jaster, Giulia Ottaviani

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Heart Failure; Gravity; Ischemia; Brain

Online: 22 March 2022 (12:38:29 CET)

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During the 90 days following hospitalization for acute heart failure, ejection fraction and type of discharge medications have been shown in clinical trials to have little effect on mortality. We examined the recent literature addressing brain-related etiologies of sudden death following heart failure. Two mechanisms of sudden unexpected death have been suggested to possibly result from 4 significant influences on pathophysiology in the brain. The two causes of death are severe cardiac arrhythmia, and neurogenic pulmonary edema. They are both mediated through the brainstem autonomic nuclei generally, and executed specifically through the dorsal motor nucleus of the vagus nerve. The four significant influences on pathophysiology in the brainstem autonomic nuclei are: 1) Hyper-stimulation of neurons in the solitary tract nucleus, increasing their metabolic requirements; 2) Inadequate blood flow at a vascular watershed terminus; 3) Additionally decreased blood flow following vasoconstriction related to relative hyperventilation and decreased pCO2 levels; 4) Gravitational ischemia in the brain—caused by the weight of the brain mass sitting above the brainstem. Changes in head tilt release gravitational ischemia in the brain. There is no specific head position (relative to gravity) that is considered favorable or unfavorable for an extended period of time (i.e. more than 24 hours). Even a small degree of head elevation, used in managing pulmonary congestion, may increase gravitational ischemia in the posterior fossa and brainstem. In this paper we suggest a new and important research avenue for intervening in cardiac arrhythmias, and preventing their occurrence, through the non-invasive use of head-tilting, and other head repositioning maneuvers. This could potentially help many geriatric patients with heart failure, who have decreased mobility in bed, and who tend to stay in one position longer, thereby increasing gravitational ischemia in the brain.

Preprint ARTICLE | doi:10.20944/preprints202405.1776.v1

CD Markers and HLA Expression in Chronic Lymphocytic Leukemia Patients: correlations and clinical relevance

Maria Tizu, Bogdan Calenic, Alexandra-Elena Constantinescu, Alexandru Adrian Bratei, Razvan Antonio Stoia, MIhnea Catalin-Gabriel Popa, Ileana Constantinescu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic lymphocytic leukemia; cluster of differentiation; human leukocyte antigen

Online: 27 May 2024 (14:27:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0662.v1

New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics

Yingyu Pan, Jianing Li, Zhengyang Fan, Yonghao Chen, Xiaoxuan Huang, Dong Wu

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic pancreatitis; probiotics; prebiotics; gut microbiota

Online: 12 August 2024 (03:05:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1479.v1

Diagnosis of Chronic Granulomatous Disease: Strengths and Challenges in the Genomic Era

Conor John O’Donovan, Lay Teng Tan, Mohd Azri Zainal Abidin, Marion Ruth Roderick, Alexandros Grammatikos, Jolanta Bernatoniene

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Inborn errors of immunity (IEI); Chronic granulomatous disease (CGD); NADPH oxidase; Nitroblue tetrazolium (NBT); Dihydrorhodamine (DHR); Genetic testing; Genomic testing; Screening

Online: 18 July 2024 (14:38:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0370.v1

Muscle Mass and Muscle Strength in Non-Dialysis Dependent Chronic Kidney Disease Patients

Katarzyna Romejko, Katarzyna Szamotulska, Aleksandra Rymarz, Stanisław Niemczyk

Subject: Medicine And Pharmacology, Internal Medicine Keywords: chronic kidney disease; skeletal muscle mass; muscle strength; anthropometric variables; clinical variables

Online: 7 May 2024 (10:45:57 CEST)

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Background Sarcopenia is a state with progressive and generalized loss of skeletal muscle mass and strength. It is a serious complication occurring in chronic kidney disease (CKD) patients which increases morbidity and mortality rate. Sarcopenia is diagnosed when loss of both compartments - muscle strength and skeletal muscle quality or quantity are present. However, there are still numerous patients, also with CKD, diagnosed as pre-sarcopenic individuals with low muscle strength and normal skeletal muscle quality or quantity and conversely, with correct muscle strength and decreased skeletal muscle mass, who are prone to develop sarcopenia in future life. It is crucial to examine numerous variables possibly associated with changes of skeletal muscle mass and muscle strength in terms of preventing the development of sarcopenia. The aim of the study was to investigate anthropometric and clinical correlates and sources of variation in both skeletal muscle mass and muscle strength in advanced stages of CKD. Methods The study sample consisted of 84 non-dialysis dependent patients of both sexes (including 45.2% of women) with eGFR < 45 ml/min/1.73m²: 26.2% with eGFR 30-44 mL/min/1.73 m², 65.5% with eGFR 15-29 mL/min/1.73 m² and 8.3% with eGFR < 15 mL/min/1.73 m². Muscle strength was estimated by measuring hand grip strength (HGS) with the use of handheld hydraulic dynamometer. Muscle quantity was measured by bioimpedance spectroscopy using Body Composition Monitor. Appendicular skeletal muscle mass (ASM) was calculated according to Lin’s formula. Serum creatinine, urea, uric acid and albumin were measured. Results In bivariate analysis we found that ASM significantly and positively correlated with anthropometric variables such as body mass (r=0.903, p<0.001), NH weight (r=0.882, p<0.001), height (r=0.694, p<0.001), body mass index (BMI) (r=0.701, p<0.001), lean tissue mass (LTM) (r=0.664, p<0.001), lean tissue index (LTI) (r=0.433, p<0.001), fat mass (r=0.614, p<0.001) and fat tissue index (FTI) (r=0.449, p<0.001), and was negatively associated with clinical variable such as hydration status (p<0.001). HGS significantly and positively correlated with anthropometric parameters such as body mass (r=0.319, p=0.003), NH weight (r=0.315, p=0.004), height (r=0.666, p<0.001), LTM (r=0.490, p<0.001), LTI (r=0.238, p=0.029), and ASM (r=0.501, p<0.001), and was negatively associated with clinical variables like uric acid (p=0.039) and urea (p<0.001). After adjustment for age, sex and height, HGS remained significantly and negatively related with uric acid (β=-1.078, p=0.041) and hydration status (β=-0.805, p=0.042). Conclusions In CKD patients, ASM is determined mainly by anthropometric parameters but HGS - both by anthropometric and clinical variables specific for CKD.

Preprint ARTICLE | doi:10.20944/preprints202312.1752.v1

Camphene as a Protective Agent in Myocardial Ischemia/ Reperfusion Injury

Rodopi Stamatiou, Maria Anagnostopoulou, Chrysa Rapti, Antigone Lazou

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: camphene; ischemia/reperfusion injury; oxidative stress; antioxidant activity; redox homeostasis

Online: 22 December 2023 (15:07:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0219.v1

The Prominin-1 Derived Peptide Improves Cardiac Function Following Ischemia

Avner Adini, irit adini, Etty Grad, Yuval Tal, Haim D. Danenberg, Peter Kang, Benjamin D. Matthews, Robert D'amato

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Myocardial infarction; Apoptosis; Angiogenesis; PR1P; Prominin-1; vacular endothelial growth factor (VEGF)

Online: 7 April 2021 (17:53:41 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202405.0204.v1

Endoscopic Picture in Chronic Rhinosinusitis Associated with Gerd

Kalamkas T. Sagandykova, Natalia M. Papulova, Talapbek M. Azhenov, Aliya Darbekova, Jerome R. Lechien

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Chronic rhinosinusitis; Endoscopic picture; Gastroesophageal reflux disease; Laryngopharyngeal reflux; Rhinosinusitis; Nasopharyngeal reflux. The Reflux Symptom Index (RSI); The Reflux Symptom Score (RSS)

Online: 6 May 2024 (08:47:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1403.v1

Botulinum Toxin in Chronic Lateral Epicondylitis, from Tendon to Muscle Approach

Daniela Poenaru, Miruna Ioana Sandulescu, Claudia-Gabriela Potcovaru, Delia Cinteza

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: botulinum toxin; lateral epicondylitis; intramuscular injection; intratendinous injection

Online: 25 March 2024 (07:57:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0967.v1

Visual Evoked Potentials Sensitization/Habituation Mechanisms in Chronic Migraine Patients with or without Medication Overuse

Gianluca Coppola, Francesco Casillo, Gabriele Sebastianelli, Chiara Abagnale, Cherubino Di Lorenzo, Antonio Di Renzo, Mariano Serrao, Vincenzo Parisi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Medication overuse; chronic migraine; visual cortex; amplitude; medication withdrawal

Online: 12 September 2024 (17:49:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2011.v1

Fractional Exhaled Nitric Oxide (FeNO) in Biomass Smoke-associated Chronic Obstructive Pulmonary Disease

Juan Silva-Gallardo, Raúl H. Sansores, Alejandra Ramírez-Venegas, Robinson Robles-Hernández, Gustavo I. Centeno-Saenz, Rafael J. Hernández-Zenteno

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Biomass COPD; FeNO; Inflammation

Online: 28 August 2024 (10:53:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0460.v1

Macular Ischemia Changes in Patients with Diabetic Macular Edema Treated with Aflibercept and Ranibizumab

Dimitrios Maris, Anna Dastiridou, Maria Kotoula, Aikaterini Karathanou, Evangelia E. Tsironi, Alexandra Bargiota, Sofia Androudi

Subject: Medicine And Pharmacology, Ophthalmology Keywords: diabetic macular edema; ranibizumab; aflibercept; ischemia; fovea avascular zone; OCT angiography

Online: 8 May 2024 (10:35:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0327.v1

The Interplay between Mitochondrial dysfunction and Ferroptosis during Ischemia-associated Central Nervous System Diseases

Heyan Tian, Boyang Huang, Huifang Nie, Xiangyu Chen, Yue Zhou, Tong Yang, Shaowu Cheng, Zhigang Mei, Jinwen Ge

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebral ischemia; central nervous system diseases; mitochondrial dysfunction, ferroptosis; therapeutics

Online: 4 August 2023 (11:02:35 CEST)

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Cerebral ischemia, which is a leading cause of disability and mortality worldwide, sets off a chain of molecular and cellular pathologies that are associated with some central nervous system (CNS) disorders, mainly including ischemic stroke, Alzheimer's disease (AD), Parkinson's disease (PD), epilepsy and other CNS diseases. In recent times, despite significant advancements in the treatment of the pathological processes underlying various neurological illnesses, effective therapeutic approaches specifically targeted at minimizing the damage of such diseases remain absent. Remarkably, ischemia causes severe damage to cells in Ischemia-associated CNS Diseases. Cerebral ischemia initiates oxygen and glucose deprivation, which subsequently promotes mitochondrial dysfunction, including MPTP opening, mitophagy dysfunction, and excessive mitochondrial fission, triggering various forms of cell death, such as autophagy, apoptosis, as well as ferroptosis. Ferroptosis, a novel type of regulated cell death (RCD), is characterized by iron-dependent accumulation of lethal reactive oxygen species and lipid peroxidation. Mitochondrial dysfunction and ferroptosis both play critical roles in the pathogenic progression of Ischemia-associated CNS Diseases. In recent years, growing evidence has indicated that mitochondrial dysfunction interplays with ferroptosis to aggravate cerebral ischemia injury. However, the potential connections between mitochondrial dysfunction and ferroptosis in Cerebral Ischemia have not yet been clarified. Thus, we analyze the underlying mechanism between mitochondrial dysfunction and ferroptosis in Ischemia-associated CNS Diseases. We also discovered that GSH depletion and GPX4 inactivation cause lipoxygenase activation and calcium influx following cerebral ischemia injury, resulting in MPTP opening and mitochondrial dysfunction. Additionally, dysfunction in mitochondrial electron transport and an imbalanced fusion-to-fission ratio can lead to the accumulation of reactive oxygen species and iron overload, which further contribute to the occurrence of ferroptosis. This creates a vicious cycle that continuously worsens cerebral ischemia injury. In this study, our focus is on exploring the interplay between mitochondrial dysfunction and ferroptosis, which may offer new insights into potential therapeutic approaches for the treatment of Ischemia-associated CNS Diseases.

Working Paper REVIEW

Therapeutic Effect of Mesenchymal Stem Cell on Organ Ischemia-Reperfusion Injury

Joan Oliva

Subject: Medicine And Pharmacology, Transplantation Keywords: ischemia-reperfusion injury; mesenchymal stem cells; treatment

Online: 11 June 2019 (04:28:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0105.v1

Histidine–Tryptophan-–Ketoglutarate Solution as a Neuroprotective Against Ischemia/Reperfusion Injury

Jiun Hsu, Chih-Hsien Wang, Shu-Chien Huang, Yung-Wei Chen, Shengpin Yu, Juey-Jen Huang, Jou-Wei Lin, Ming-Chih Ma, Yih-Sharng Chen

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: 1; brain protection 2; HTK 3; cardiac arrest 4; hypoxic injury 5; HIF-1α

Online: 5 October 2018 (15:45:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0497.v1

Combined Epiretinal Proliferation and Internal Limiting Membrane Inverted Flap for the Treatment of Large Macular Holes

Nikolaos Dervenis, Iordanis Vagiakis, Elena P Papadopoulou, Panagiotis Dervenis, Maria Teresa Sandinha

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Epiretinal proliferation; macular hole; macular surgery; pars plana vitrectomy

Online: 6 September 2024 (09:36:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0142.v1

Dynamic Interrelations between Sensory and Affective Aspects of Pain in Patients with Chronic Pain

Tatyana Telbizova

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic pain; depressive episode; state and trait anxiety, correlations

Online: 3 May 2024 (04:06:07 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202405.1571.v1

Development of Epidemiological Research Guidelines for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome in Canada

Enkhzaya Chuluunbaatar-Lussier, Travis Boulter, Sunita Vohra, Rahul Shetty, Sharon Houle, Riina Bray, Kathleen Kerr, Luis Nacul

Subject: Public Health And Healthcare, Other Keywords: myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), research guidelines, standardization of data collection, Canadian

Online: 23 May 2024 (14:17:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0947.v1

Tumid Lupus Erythematosus (TLE): a review of a rare variant of chronic Cutaneous Lupus Erythematosus (cCLE) with emphasis on differential diagnosis

Maged Daruish, Francesca Ambrogio, Caterina Foti, Alessandra Filosa, Gerardo Cazzato

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Tumid Lupus Erythematosus; Systemic Lupus Erythematosus; cCLE; inflammatory dermatopathology

Online: 18 March 2024 (08:19:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2081.v1

Prevalence, Characteristics, and Awareness of Chronic Kidney Disease in Croatia. The EH-UH 2 Study

Ana Jelaković, Danilo Radunović, Josipa Josipović, Tajana Željković Vrkić, Lana Gellineo, Marija Domislović, Vladimir Prelević, Marijana Živko, Mirjana Fuček, Mihaela Marinović Glavić, Nikolina Bašić‐Jukić, Ivan Pećin, Marija Bubaš, Krunoslav Capak, Bojan Jelaković

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: albuminuria; awareness; chronic kidney disease; cardiovascular risk; eGFR (CKD Epi) formula; glomerular filtration rate; national population survey

Online: 28 August 2024 (14:45:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0053.v2

Machine Learning Driven Dashboard for Chronic Myeloid Leukemia Prediction using Protein Sequences

Waqar Ahmad, Abdul Raheem Shahzad, Muhammad Awais Amin, Waqas Haider Bangyal, Tahani Jaser Alahmadi, Saddam Hussain Khan

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Protein Sequences; Pseudo-AAC; AAC; Dipeptide-C; Machine Learning Classifiers; Chronic Myeloid Leukemia; Blood Cancer

Online: 26 June 2024 (10:02:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0909.v1

A Review of the Scope of Wearable Ultrasonic Sensors for Ischemia Monitoring

Evan Brophy, Masudul Imtiaz

Subject: Engineering, Electrical And Electronic Engineering Keywords: Blood Pressure; Ischemia Monitoring; Wearable Ultrasonic Sensor

Online: 15 November 2023 (03:51:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0386.v1

The Power of Nutraceuticals Fighting Liver Ischemia–Reperfusion Injury Through Apoptosis Reduction

Carlos Andrés Pantanali, Vinicius Rocha-Santos, Márcia Saldanha Kubrusly, Inar Alves Castro, Luiz Augusto Carneiro-D’Albuquerque, Flávio Henrique Galvão

Subject: Medicine And Pharmacology, Transplantation Keywords: nutraceuticals; liver; ischemia-reperfusion injury; apoptosis

Online: 6 May 2023 (05:46:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0193.v1

Current Status of Cell-Based Therapy in Patients with Critical Limb Ischemia

Frantisek Jaluvka, Peter Ihnat, Juraj Madaric, Vaclav Prochazka

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Cell therapy, Peripheral arterial disease, Bone marrow, Adipose tissue, Mesenchymal stem cells, Exosome, Critical limb ischemia.

Online: 4 November 2020 (12:37:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0323.v1

Potential Active Ingredients of Traditional Chinese Medicine NaoMaiTong for Ischemia Stroke Treatment

Yu Zhang, Xulei Fan, Li Lu, Shumei Wang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Potential active ingredients; Naomaitong; PK - PD correlation; Support vector machines

Online: 24 May 2018 (10:38:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1125.v1

Predictive Analysis of Osteoarthritis and Chronic Pancreatitis Comorbidity: Complications and Risk Factors

Iryna Halabitska, Liliia Babinets, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: osteoarthritis; chronic pancreatitis; comorbidity; complications; risk factors; predictors.; pancreatitis

Online: 15 July 2024 (10:26:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1209.v1

Pancreatectomy With En Bloc Superior Mesenteric Vein And All Its Tributaries Resection Without PV/SMV Reconstruction For “Low” Locally Advanced Pancreatic Cancer

VIACHESLAV EGOROV, Pavel Kim, Soslan Dzigasov, Eugeny Kondratiev, Alexander Sorokin, Alexey Kolygin, Mikhail Vyborniy, Grigoriy Bolshakov, Pavel Popov, Anna Demchenkova, Tatiana Dakhtler

Subject: Medicine And Pharmacology, Surgery Keywords: locally advanced PDAC; vein resection without PV/SMV reconstruction; pancreatic cancer; portal venous collaterals; low pancreatic cancer; superior mesenteric vein occlusion; CT-based venous reconstructions

Online: 20 May 2024 (07:05:54 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202405.2167.v1

Adult-Onset Systemic Chronic Active Epstein - Barr virus Disease: A Case Report Highlighting Unique Immunophenotype and Novel Molecular Insights in the Context of Chronic HBV Hepatitis

Tulasi Geevar, Peter JB Sabatini, Tong Zhang, Ali Sakhdari

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chronic EBV infection; T cell lymphoproliferative disorder; mutational profile

Online: 3 June 2024 (07:58:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0365.v2

Chronic Inflammation and Blood Cancer

Nikolaos Tzenios, Mary Tazanios, Mohamad Chahine

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: blood cancer; chronic inflammation; inflammation; mutation; tumor

Online: 24 November 2022 (02:55:44 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0601.v1

Successful Aging and Chronic Osteoarthritis

Ray Marks

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: aging; disability; healthy aging; osteoarthritis; pain, rehabilitation, successful aging

Online: 30 July 2018 (22:20:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1518.v1

A Significance of Endothelial Dysfunction in Long COVID-19 for The Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama, Akahito Sako

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atherosclerotic cardiovascular disease; chronic kidney disease; endothelial dysfunction; long coronavirus disease 19.

Online: 21 June 2024 (11:45:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0774.v1

Myocardial Perfusion Imaging and C-reactive Protein in Myo-Cardial Ischemia: A Retrospective Single-Center Study

Aidonis Rammos, Aris Bechlioulis, Areti Kekiopoulou, Pavlos Kekiopoulos, Christos S. Katsouras, Chrissa Sioka

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: C-reactive protein; ischemia; SPECT; myocardial perfusion imaging; cardiac imaging

Online: 10 January 2024 (10:08:28 CET)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202404.1375.v1

Immediate Implants Placement with Immediate Restorations after Dental Avulsions Due to Endotracheal Intubation in a Patient with Severe Chronic Periodontal Disease

Alexandre Perez, Adriana Fernandez Bargiela, Tommaso Lombardi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental implant; Immediate implant; Immediate restoration; Periodontitis; Trauma; Endotracheal intubation

Online: 22 April 2024 (16:35:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0837.v1

Analysis and Interpretation of Automated Blood Count in the Treatment of Chronic Paracoccidioidomycosis

Eliana da Costa Alvarenga de Brito, Adriana de Oliveira França, Igor Valadares Siqueira, Vinícius Lopes Teodoro Félix, Amanda Alves Rezende, Bárbara Casella Amorim, Suzane Eberhart Ribeiro Da Silva, Rinaldo Poncio Mendes, Simone Schneider Weber, Anamaria Mello Miranda Paniago

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: anemia; blood cell count; leukocyte count; paracoccidioidomycosis

Online: 18 March 2024 (06:37:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2562.v1

Comparative Analysis of the Effect of Beta Blockers of Different Generations on the Parameters of Myocardial Energy Metabolism in Experimental Doxorubicin-Induced Chronic Heart Failure

Igor Belenichev, Olexiy Goncharov, Nina Bukhtiyarova, Oleh Kuchkovskyi, Victor Ryzhenko, Lyudmyla Makyeyeva, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic heart failure; beta blockers; energy metabolism; mitochondria; Hypertril

Online: 31 July 2024 (12:36:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0803.v1

Caregivers of People with Chronic Kidney Disease: A Potential Ally to Enhance Delivery of Nutrition Care

Georgina Lockwood, Lucimay Davey, Catherine McFarlane, Nicholas A Gray, Hattie Wright

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: diet therapy; family caregiver; food literacy; nutrition knowledge; meal provision; dietary adherence

Online: 10 September 2024 (11:10:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1629.v1

Burr Hole Craniostomy Versus Craniotomy for Chronic Subdural Hematoma – A Multicenter Study

Nenad Koruga, Djula Djilvesi, Anamarija Soldo Koruga, Vjekoslav Kopačin, Tatjana Rotim, Tajana Turk, Slavko Čičak, Josip Kocur, Marija Perić, Tomislav Ištvanić, Vedran Farkaš, Sonja Škiljić, Alen Rončević

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Burr hole craniostomy; Craniotomy; Chronic subdural Hematoma; Multicenter study

Online: 25 April 2024 (08:38:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0249.v1

Ultra-High Resolution Electrocardiography Enables Earlier Detection of Transmural and Subendocardial Myocardial Ischemia Compared to Conventional Electrocardiography

Kirill V. Zaichenko, Anna A. Kordyukova, Dmitry L. Sonin, Michael M. Galagudza

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart; ischemia; reperfusion; electrocardiography; ultra-high resolution electrocardiography; power spectral density; ischemic heart disease; subclinical atherosclerosis; sensitivity; risk stratification

Online: 3 August 2023 (05:17:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1055.v1

A Comprehensive Overview of Innovative Approaches to Prevent Kidney Ischemia-Reperfusion Injury: Bibliometric and In Silico Analyses

Myltykbay S. Rysmakhanov, Afshin Zare, Aibolat S. Smagulov, Nurgul A. Abenova, Nadiar M. Mussin, Yerlan B. Sultangereyev, Bazylbek S. Zhakiyev, Gani K. Kuttymuratov, Mehmet Haberal, Nazanin Jafari, Hanieh Baneshi, Shabnam Bakhshalizadeh, Mahdi Mahdipour, Farhad Rahmanifar, Amin Tamadon

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Ischemia/reperfusion injury; Molecular docking; Bibliometric analysis; Kidney reperfusion; Kidney transplantation; Renal resection

Online: 27 April 2023 (07:25:20 CEST)

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Ischemia-reperfusion injury (IRI) is a complex pathophysiological process that can lead to severe and irreversible consequences, including the complete loss of renal function. While standardized strategies for preventing IRI during "back-table" and cold preservation are available, various intraoperative prevention methods have been proposed to mitigate the harmful effects of warm ischemia and reperfusion of the kidney. These methods include pharmacological agents, mechanical interventions, and surgical techniques such as renal capsulotomy, ischemic preconditioning, venous blood reperfusion, renal perfusion, and the use of tissue engineering techniques like mesenchymal stromal/stem cells and/or decellularization. In this comprehensive analysis, we provide a detailed overview of pharmacological agents and intraoperative methods and approaches for the prevention and treatment of renal IRI. We begin by discussing the mechanisms of IRI and the challenges of preventing it during surgery. Then using a bibliometric analysis and molecular docking of brand-new legends we showed eplerenone have the most binding affinity to Aldehyde dehydrogenase (AD), Estrogen receptor (ER), Klotho protein, Mineralocorticoid receptor (MR), and Toll-like receptor 4 (TLR4) for preventing IRI comparing with other available therapeutics, Benzodioxole, Hydrocortisone, Indoles, Nicotinamide adenine dinucleotide, and Niacinamide. Next, we provide a comprehensive analysis of the potential benefits and limitations of various prevention strategies, including an in-depth discussion of the mechanisms of action of pharmacological agents, mechanical interventions, and surgical techniques. Furthermore, we introduce a novel scoring system for the prevention methods of kidney IRI, which takes into account the effectiveness, feasibility, and safety of each method. We then analyze the current state of clinical research in this area and discuss the implications of these methods for future clinical practice. Overall, this article provides a valuable resource for clinicians and researchers seeking to prevent and treat renal IRI in surgical settings, and introduces a new scoring system that can be used to guide the selection of the most effective and safe prevention methods.

Preprint ARTICLE | doi:10.20944/preprints202409.0414.v1

Triple Therapy De-escalation and Withdrawal of Inhaled Corticosteroid to Dual Bronchodilator Therapy in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis

Edoardo Pirera, Domenico Di Raimondo, Antonino Tuttolomondo

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Chronic Obstructive Pulmonary Disease (COPD); inhaled corticosteroids (ICS); de-escalation therapy; Acute Exacerbation of COPD (AECOPD); pneumonia; eosinophils

Online: 6 September 2024 (05:51:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1185.v1

Association Between Chronic Hepatitis B / C and Incidence of Osteoporosis and Bone Fractures: Results from a Retrospective Cohort Study

Sven H. Loosen, Alexander Killer, Hans Henrich Bock, Tom Luedde, Christoph Roderburg, Karel Kostev

Subject: Medicine And Pharmacology, Hematology Keywords: HBV; HCV; CHC; CHB; osteopenia; virus; infection; regression

Online: 16 September 2024 (10:17:56 CEST)

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Working Paper ARTICLE

Neuroprotective Effects of Metformin on Cerebral Ischemia-Reperfusion Injury by Regulating PI3K/Akt Pathway

cailian ruan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Metformin; cerebralischemia-reperfusion; inflammation; PI3K/Akt.

Online: 12 March 2021 (08:43:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0194.v2

Whole body vibration therapy after ischemia reduces brain damage in reproductively senescent female rats

Ami P. Raval, Marc Schatz, Pallab Bhattacharya, Nathan d’Adesky, Tatjana Rundek, W. Dalton Dietrich, Helen M. Bramlett

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: brain-derived neurotrophic factor; Frailty; Inflammasome proteins; Interleukin-1β; Peri-infarct area

Online: 23 August 2018 (07:59:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0146.v1

Chronic Ambient Poisoning

Beth Alderman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: ubiquitous exposure; diagnosis; research design; quality of health care; habitat injuries; discovery

Online: 11 May 2022 (05:40:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1272.v1

Therapeutic Vaccination in Chronic Hepatitis B: A Systematic Assessment by the HeberNasvac Therapeutic Vaccine Team

Julio Cesar Aguilar, Sheikh Mohammad Fazle Akbar, Mamun Al-Mahtab, Carlos Alberto Guzman, Guillermo Fernandez, Jorge Aguiar, Marie-Louise Michel, Maryline Bourgine, Maria Acelia Marrero, Stephanie Trittel, Thomas Ebensen, Peggy Riese, Roger LeGrand, Cecile Herate, Aurelie Mauras, Heiner Wedemeyer, Osamu Yoshida, Yoichi Hiasa, Eduardo Penton, Gerardo Guillen

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chronic hepatitis; therapeutic vaccine; functional cure; antiviral; therapy

Online: 19 August 2024 (12:05:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1890.v1

Impaired Coordination of the Ciliary Movement in Patients with Chronic Rhinosinusitis with Nasal Polyps: The Role of Decreased Planar Cell Polarity Protein Expression

Sakura Hirokane, Tomohiro Kawasumi, Sachio Takeno, Yukako Okamoto, Seita Miyamoto, Rikuto Fujita, Chie Ishikawa, Takashi Oda, Yuichiro Horibe, Takashi Ishino, Takao Hamamoto, Tsutomu Ueda

Subject: Medicine And Pharmacology, Otolaryngology Keywords: paranasal sinus; chronic rhinosinusitis; CRS; nasal polyps; ciliated cell; mucociliary clearance; planar cell polarity; CPLANE complex proteins; WDPCP; FUZ

Online: 24 July 2024 (08:02:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1124.v1

Cardioprotective Effect of Epiisopiloturine, an Imidazole Alkaloid from Pilocarpus microphyllus, in Rats Submitted to Cardiac Ischemia and Reperfusion

Pedro Ivo De Marqui Moraes, Fernando Sabia Tallo, Rildo Yamaguti Lima, Sandra Augusta Gordinho Pinto, Erisvaldo Amarante De Araújo, Rodrigo de Barros Freitas, Carolina Trabasso Ferraz De Oliveira, Giovanna Seto De Oliveira, João Vitor Gardelli Trindade, Alexia Nascimento Arias, Rafael Batman de Góes, Carlos Eduardo Braga Filho, Jand Venes Rolim Medeiros, Lucas Antonio Duarte Nicolau, Leiz Maria Costa Véras, Monica Noleto Miranda, Almir Gonçalves Wanderley, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiac Diseases; Cardiac Ischemia-Reperfusion; Myocardial Infarction; Pharmacological Cardioprotection; Epiisopiloloturine

Online: 17 November 2023 (05:22:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0227.v1

Ischemia-Reperfusion Intervention: From Enhancements in Exercise Performance to Accelerates Performance Recovery - A Systematic Review and Meta-Analysis

Rhaí André Arriel, Jéssica Ferreira Rodrigues, Hiago Leandro Rodrigues de Souza, Anderson Meireles, Luís Filipi Moutinho Leitão, Antonio Crisafulli, Moacir Marocolo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Intermittent occlusion; Blood flow occlusion; Sports; Ergogenic; Ischemic postconditioning

Online: 12 October 2020 (10:42:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0083.v1

UPEI-400, a Conjugate of Lipoic Acid and Scopoletin, Mediates Neuroprotection in a Rat Model of Ischemia/Reperfusion

Barry J. Connell, Monique C. Saleh, Desikan Rajagopal, Tarek M. Saleh

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: stroke; antioxidant; co-drug; animal model

Online: 20 October 2016 (08:46:38 CEST)

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Background: Previously, our laboratory has provided evidence that pre-administration of the antioxidant, lipoic acid covalently bonded to various naturally occurring antioxidants, enhanced neuroprotective capacity compared to the administration of lipoic acid on its own. The naturally occurring compound scopoletin, a coumarin derivative, has been shown in various in vitro studies to have both antioxidant and anti-inflammatory mechanism of actions. To date, the effect of scopoletin on neuronal cell death in an in vivo model of ischemia or ischemia-reperfusion has not been investigated. Therefore, the present investigation was designed to determine if scopoletin on its own, or a co-drug consisting of lipoic acid and scopoletin covalent bond, named UPEI-400, would be capable of demonstrating a similar neuroprotective efficacy. Methods: Using a rodent model of stroke in male rats (anesthetized with Inactin®; 100 mg/kg, iv), the middle cerebral artery was permanently occluded for 6 hours (pMCAO), or in separate animals, occluded for 30 min followed by 5.5 hrs of reperfusion (ischemia/reperfusion; I/R). Results: Pre-administration of either scopoletin or UPEI-400 significantly decreased infarct volume in the I/R model (p<0.05), but not in the pMCAO model of stroke. However, UPEI-400 was ~1000 times more potent as compared to scopoletin on its own. The optimal dose of UPEI-400 was then injected during the occlusion and at several time points during reperfusion and significant neuroprotection was observed for up to 150 mins following the start of reperfusion (p<0.05). Conclusion: The data suggest that synthetic combination of scopoletin with lipoic acid (UPEI-400) is a more effective neuroprotectant that either compound on their own. Also, since UPEI-400 was only effective in a model of I/R, it is possible that it may act to enhance neuronal antioxidant capacity and/or upregulate anti-inflammatory pathways to prevent the neuronal cell death.

Preprint COMMUNICATION | doi:10.20944/preprints202406.1539.v1

The Pathway Flow Starting From Chronic Reactive Oxygen Species Leading to Human Treatment-Resistant Gastric Cancer

Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Hiroshi Yokozaki, Hiroki Sasaki, Edward Perkins

Subject: Biology And Life Sciences, Life Sciences Keywords: Adverse Outcome Pathway (AOP); epithelial-mesenchymal transition; gastric cancer; reactive oxygen species (ROS); Wnt signaling

Online: 24 June 2024 (04:30:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1789.v1

Chronic Granulomatous Disease (CGD): Pathogens and Management

Angel A. Justiz-Vaillant, Arlene Faye-Ann Williams-Persad, Rodolfo Arozarena-Fundora, Darren Gopaul, Sachin Soodeen, Odalis Asin-Milan, Clovis Palmer, Patrick Eberechi Akpaka

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chronic granulomatous disease; Microorganisms; Neutrophils; Antimicrobials

Online: 26 July 2023 (10:39:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1557.v1

Chronic Granulomatous Disease (CGD): Pathogens and Management

Angel A. Justiz-Vaillant, Arlene Faye-Ann Williams-Persad, Rodolfo Arozarena-Fundora, Patrick Eberechi Akpaka, Darren Gopaul

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic granulomatous disease; Microorganisms; Neutrophils; Antimicrobials

Online: 21 June 2023 (13:10:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1542.v1

Morphological and Functional Alterations in the CA1 Pyramidal Neurons of the Rat Hippocampus in the Chronic Phase of the Lithium-Pilocarpine Model of Epilepsy

Tatyana Y. Postnikova, Georgy P. Diespirov, Sergey L. Malkin, Alexander S. Chernyshev, Elizaveta N. Vylekzhanina, Aleksey V. Zaitsev

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: temporal lobe epilepsy; 4-aminopyridine model; pyramidal neuron; action potential; ictal discharge

Online: 24 June 2024 (04:32:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0199.v1

Clinicopathological Variables and Outcome in Chronic Phase Chronic Myeloid Leukemia Associated with BCR-ABL1 Transcript Type and Body Weight

Mohammad Abdulla, Prem Chandra, Susanna El Akiki, Claudio Sorio, Luisa Tomasello, Christian Boni, Mohamed Yassin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; BCR-ABL1 transcript; obesity

Online: 7 August 2020 (13:07:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1351.v1

Berberine Mediates the Production of Butyrate to Ameliorate Cerebral Ischemia via Gut Microbiota in Mice

Huijie Duan, Junya Hu, Yang Deng, Junqing Zou, Wangli Ding, Qiang Peng, Rui Duan, Jianguo Sun, Junrong Zhu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Stroke; gut microbiota; butyric acid; microglia; astrocytes; NLRP3

Online: 20 October 2023 (11:53:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201708.0015.v1

Omega-3 polyunsaturated fatty acids protect against ischemia-reperfusion renal injury through AMPK-mediated autophagy

Do Hyeong Gwon, Tae Woong Hwang, Ju-ye Ro, Yoon-Joong Kang, Jin Young Jeong, Do-Kyung Kim, Kyu Lim, Dong Woon Kim, Dae Eun Choi, Jwa-Jin Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ischemia-reperfusion injury (IRI), ω3-PUFA, AMP-activated protein kinase (AMPK), autophagy

Online: 4 August 2017 (12:56:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0174.v1

A Decades-Long Journey of Palmitoylethanolamide (PEA), as a Cornerstone in Chronic Neuropathic Pain Management: A Comprehensive Narrative Review

Giustino Varrassi, Antonella Paladini, Chiara Corno, Stefano Coaccioli, Gabriele Finco, Domenico Tiso, Diego Fornasari

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Degenerative neuropathies; Pain; Neuropathic Pain; Mixed Pain; Palmitoylethanolamide (PEA); EquiPEA^®; ; Personalized medicine strategies

Online: 4 March 2024 (14:09:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2264.v1

Dietary Omega-3 PUFA Intake in Patients with Chronic Kidney Disease: The Association with Vitamin D Deficiency, Intima-Media Thickness and Blood Pressure

Danijela Ristic-Medic, Marija Takic, Biljana Pokimica, Brankica Terzic, Milica Kojadinovic, Toplica Lepic, Slavica Radjen, Vesna Vucic

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: omega-3; carotid intima-media thickness; chronic kidney disease; cardiovascular risk; hemodialysis

Online: 30 August 2024 (15:32:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0041.v1

Genetics of Vascular Inflammation in Lower Limb Ischemia: The TNF-α Hypothesis in Peripheral Arterial Disease

Diego Caicedo, Clara V. Álvarez, Sihara Pérez, Jesús Devesa

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Vascular inflammation; Peripheral arterial disease (PAD); Chronic limb-threatening ischemia (CLTI); GHAS trial; TNF-α; hs-CRP; Neutrophil-to-lymphocyte ratio (NLR); NOX4; eNOS; VEGF-A.

Online: 3 December 2021 (09:44:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1787.v1

Vitamin D deficiency, Chronic kidney disease and Periodontitis

Imaan Ganimusa, Emily Chew, Emily Ming-Chieh Lu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Vitamin D, Chronic kidney disease, periodontitis

Online: 24 January 2024 (16:53:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1274.v1

Immunogenicity and Safety of the Recombinant Adjuvanted Herpes Zoster Vaccine in Patients with Chronic Lymphocytic Leukemia and Multiple Myeloma

Panagiotis T. Diamantopoulos, Christos Stafylidis, Vassiliki Labropoulou, Christina-Nefeli Kontandreopoulou, Dimitra Vlachopoulou, Stavroula Smilakou, Iraklis Patsialos, Stavroula Syriopoulou, Alexandros Gkikas, Eleftherios N Athanasopoulos, Anastasios Vogiatzakis, Eleni Panousi, Georgios Kyriakakis, Amalia Anastasopoulou, Marina Mantzourani

Subject: Medicine And Pharmacology, Hematology Keywords: Varicella-zoster virus (VZV); chronic lymphocytic leukemia; multiple myeloma; recombinant adjuvanted herpes zoster vaccine (RZV); immunogenicity; safety

Online: 17 September 2024 (03:34:58 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202406.0239.v1

Endoscopic Features of Chronic Rhinosinusitis in Patients with Gastoesophageal Reflux Disease

Kalamkas Sagandykova, Nataliya Papulova, Talapbek Azhenov, Aliya Darbekova, Bayan Aigozhina, Jerome R. Lechien

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Endoscopic picture; Laryngopharyngeal reflux; Rhinosinusitis; Nasopharyngeal reflux; The Reflux Symptom Index; The Reflux Symptom Score

Online: 5 June 2024 (10:56:24 CEST)

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Chronic rhinosinusitis (CRS) is a complex inflammatory condition affecting the nasal and paranasal sinus mucosa. Gastroesophageal reflux disease (GERD) has been implicated as a potential exacerbating factor in CRS, but the specific endoscopic features of nasopharyngeal pathology in this context remain poorly understood. Background and Objectives: CRS is a multifactorial disease with various underlying etiologies, including inflammation, anatomical factors, and environmental triggers. While GERD has been suggested as a potential contributor to CRS, the specific endoscopic features indicative of nasopharyngeal pathology in CRS patients with GERD symptoms have not been clearly elucidated. Our aim is to identify specific endoscopic features of nasopharyngeal pathology in patients with CRS associated with GERD symptoms, and to propose a method for assessing the influence of GERD on the mucosal layer of the nose and nasopharynx. Materials and Methods: We conducted a cross-sectional observational study involving 521 adult patients presenting with symptoms suggestive of CRS. From this cohort, 95 patients with the highest scores on the Reflux Symptom Index (RSI) and Reflux Symptom Score-12 (RSS-12) questionnaires were selected as the main group. Endoscopic examinations were performed to assess the nasal and nasopharyngeal mucosa. Results: Our study revealed significant alterations in the nasopharyngeal mucosa of patients with CRS associated with GERD symptoms. Increased vascularity of the nasopharyngeal mucosa was observed in 91 patients (95.7%), while hypertrophy was noted in 83 patients (87.4%). Mucus was present in the nasopharynx of 77 patients (81.1%), exhibiting varying characteristics of color and consistency. Asymmetric hypertrophy of the oropharyngeal mucosa was noted in 62 patients (65.3%). Conclusions: We propose a method for assessing the influence of GERD on the mucosal layer of the nose and nasopharynx, which may aid in diagnostic and management decisions. Further research is warranted to explore the potential impact of GERD symptoms on the course and severity of CRS exacerbations.

Preprint ARTICLE | doi:10.20944/preprints202403.1518.v1

Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy

Juliane Wagner, Luisa Haker, Louisa Mewes, Corinna Bang, Malte Rühlemann, Hendrik Naujokat, Johannes Heinrich Spille, Wolfgang Lieb, André Franke, Stefan Schreiber, Matthias Laudes, Christof Dörfer, Jörg Wiltfang, Christian Graetz, Dominik Maria Schulte

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chronic inflammation; periodontitis; microbiome; anti-cytokine therapy

Online: 26 March 2024 (11:03:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0019.v1

Hyperleptinemia Results in Systemic Inflammation and the Exacerbation of Ischemia-Reperfusion Myocardial Injury: The Involvement of the JAK/STAT Pathway

Ekaterina A. Polyakova, Evgeny N. Mikhaylov, Mikhail M. Galagudza, Evgeny V. Shlyakhto

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: leptin; JAK/STAT pathway; myocardial infarction; hemodynamics; arrhythmias; dyslipidaemia; inflammation; cardiac remodeling

Online: 2 August 2021 (11:24:57 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202304.0616.v1

Circulating CD34+/CD38-/CD26+ Leukemia Stem Cells along Chronic Myeloid Leukemia progression: differences between Chronic, Accelerated and Blast Phase

Paola Pacelli, Anna Sicuranza, Elena Bestoso, Alessandra Iurlo, Elisabetta Abruzzese, Adele Santoni, Margherita Malchiodi, Cristina Marzano, Elisabetta Zappone, Donatella Raspadori, Monica Bocchia

Subject: Medicine And Pharmacology, Hematology Keywords: CP-CML; Accelerated Phase (AP); Blast Phase (BP); CD26+LSCs

Online: 20 April 2023 (07:31:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0104.v3

Chronic Pain Treated with the CMECD Procedure

Roger Howard Coletti

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: EMG; muscle; spontaneous electrical activity (SEA); spasm; pain; CMECD protocol; phenoxybenzamine-lidocaine mixture

Online: 28 February 2022 (12:10:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0348.v1

Accuracy of Anti-SARS-CoV2 Antibody in Comparison with Surrogate Viral Neutralization Test in Person Living with HIV, Systemic Lupus Erythematosus and Chronic Kidney Disease

Marita Restie Tiara, Chrisan Bimo Prayuda, Tara Titian Maulidya, Hofiya Djauhari, Dadang Suhendar, Rudi Wisaksana, Laniyati Hamijoyo, Rudi Supriyadi, Agnes Rengga Indrati, Bachti Alisjahbana

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; vaccination; antibody; immunoassay; neutralization antibody

Online: 4 April 2024 (05:53:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1519.v1

A Multi-epitope Protein for High-Performance Serodiagnosis of Chronic Chagas Disease in Elisa and Lateral Flow Platforms

Evandro R. Dias, Andressa M. Durans, Barbara B. Succar, Luiz André L. T. Pinto, Guilherme C. Lechuga, Mariana G. Miguez, Janaina Figueira-Mansur, Ana Paula C. Argondizzo, Aline R. Bernardo, Rafaela L. Diniz, Gabriela S. Esteves, Edimilson D. Silva, Carlos M. Morel, José Borges-Pereira, Salvatore Giovanni De-Simone, Angela C. V. Junqueira, D. William Provance, Jr

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chagas disease; Diagnostics; ELISA; Lateral Flow tests; Synthetic protein; T. cruzi

Online: 21 August 2024 (08:40:17 CEST)

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Working Paper ARTICLE

Aerobic Exercise Attenuates Myocardial Ischemia-Reperfusion Injury in Rats by Regulating The SIRT3/SOD2/NF-κB Pathway

cailian ruan, Yan Yang, ZiLin Li

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Aerobic exercise; Myocardial ischemia/reperfusion; autophagy; SIRT3; SOD2; NF-κB; Biochemical indicators

Online: 1 April 2021 (13:28:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0128.v1

Novel Role of MCP-Induced Protein 1 in Ischemic Brain Damage in Animals of Transient Focal Ischemia

Zhuqing Jin, Jian Liang, Jiaqi Li, Pappachan E. Kolattukudy

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: middle cerebral artery occlusion (MCAO); MCPIP1; blood-brain barrier; inflammatory response; ischemia; metalloproteinases

Online: 11 December 2018 (10:49:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.1372.v1

Trends in Physiotherapy of Chronic Low Back Pain Research: Knowledge Synthesis Based on Bibliometric Analysis

Urška Šajnović, Peter Kokol, Jernej Završnik, Helena Vošner Blažun

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: physiotherapy; chronic low back pain; knowledge synthesis; bibliometric; development of studies

Online: 20 June 2024 (00:23:20 CEST)

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