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Preprint ARTICLE | doi:10.20944/preprints202405.1949.v1

⁶⁴Cu²⁺Complexes of Tripodal Amine Ligands on In Vivo Tumor and Liver Uptake and Intracellular Cu Distribution in the Extrahepatic Bile Duct Carcinoma Cell Line TFK-1: A Basic Comparative Study

Mitsuhiro Shinada, Masashi Takahashi, Chika Igarashi, Hiroki Matsumoto, Fukiko Hihara, Tomoko Tachibana, Masakazu Oikawa, Hisashi Suzuki, Ming-Rong Zhang, Tatsuya Higashi, Hiroaki Kurihara, Yukie Yoshii, Yoshihiro Doi

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: copper requirement; cancer; PIXE; tripodal amine ligands; ⁶⁴Cu²⁺ ion; ⁶⁴Cu²⁺ complexes

Online: 29 May 2024 (14:16:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1751.v1

Antioxidant Activity of Planar Catechin Conjugated with Trolox

Wakana Shimizu, Yoshimi Shoji, Kei Ohkubo, Hiromu Ito, Ikuo Nakanishi, Kiyoshi Fukuhara

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: catechin; trolox; tocopherol; antioxidant activity

Online: 23 August 2024 (17:13:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1393.v1

Emotional Eating and Uncontrolled Eating as Risk Predictors for Disordered Eating Attitudes in Candidates for Bariatric Surgery Treated at a Public Hospital in the Amazon

Jeane Lorena Dias Kikuchi, Manuela Maria de Lima Carvalhal, Millena Borges Inete, Yasmym Dannielle do Espírito Santo Souza, Tainá Martins Moraes, Rafaela Lorena Viana Costa, Rafaelle Dias Gabbay, Carla Cristina Paiva Paracampo, Daniela Lopes Gomes

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: obesity; bariatric surgery; eating behavior; eating disorders

Online: 22 April 2024 (10:15:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0159.v2

On the Vacuum Energy of the Universe at the Galaxy Level, the Cosmological Level and the Quantum Level

Engel Roza

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Milgrom’s acceleration constant; Bekenstein-Hawking entropy; gravitational dipole; dark matter

Online: 23 May 2023 (08:04:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0060.v1

The Relationship between Rhythmic Temporal Attention and Endogenous and Exogenous Spatial Attention

Xiaoxiao Li, Yong Lyu

Subject: Social Sciences, Psychology Keywords: rhythm; temporal attention; endogenous spatial attention; exogenous spatial attention

Online: 1 March 2024 (16:52:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.2103.v1

Exploring the Role of p53 in Radiosensitivity: A Key Player in Cancer Therapy

Tusher -Al-Arafat, Aihong Mao, Takanori Katsube, Bing Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: radiation; p53; radiosensitivity; cancer therapy; DNA damage and repair; Apoptosis

Online: 29 August 2024 (12:07:42 CEST)

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Radiotherapy remains a cornerstone in cancer treatment, leveraging ionizing radiation to eradicate malignant cells. Its efficacy, however, is frequently challenged by the heterogeneous sensitivity of tumors and surrounding tissues to radiation. Therefore, understanding the molecular mechanisms underlying radiosensitivity is crucial for improving treatment outcomes. Among the myriad of molecular players involved, the tumor suppressor protein p53 stands out as a central regulator with significant implications for radiosensitivity. Known as the “guardian of the genome,” p53 plays a pivotal role in maintaining genomic stability and orchestrating cellular responses such as cell cycle arrest, DNA repair, apoptosis, and senescence in response to various stress signals, including radiation-induced DNA damage. Activation of p53 triggers the transcription of target genes involved in DNA repair pathways, such as p21, MDM2, and GADD45, facilitating the repair of radiation-induced DNA damage or the elimination of irreparably damaged cells. This, in turn, influences the overall radiosensitivity of tissues. Mutations in the TP53 gene, which encodes p53, are among the most frequent genetic alterations in human cancers. Loss or dysfunction of p53 can compromise the cellular response to radiation, leading to increased resistance to therapy and poorer clinical outcomes. Conversely, intact p53 function is associated with enhanced radiosensitivity due to its ability to promote cell cycle arrest and apoptosis in response to radiation-induced DNA damage. In conclusion, elucidating the molecular mechanisms by which p53 influences radiosensitivity is essential for advancing our understanding of radiation response in cancer cells and developing more effective therapeutic approaches in cancer treatment. This review provides a comprehensive overview of the multifaceted role of p53 in modulating cellular responses to radiation, emphasizing its influence on radiosensitivity.

Preprint ARTICLE | doi:10.20944/preprints202403.1706.v2

CAS Key Laboratory of Quantum Information, University of Science and Technology of China

Xiao-Yan Yang, Hai-Feng Zhang, Peng Duan, Lei Du, Hao-Ran Tao, Liang-Liang Guo, Tian-Le Wang, Zhi-Long Jia, Wei-Cheng Kong, Guo-Ping Guo

Subject: Physical Sciences, Quantum Science And Technology Keywords: quantum computation; microwave crosstalk; superconducting circuit

Online: 23 April 2024 (12:47:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1515.v1

A Best-Path Approach to the Design of a Hybrid Space-Ground Quantum Network with Dynamic Constraints

David L. Bakker, Yannick Jong, Bob P. F. Dirks, Gustavo C. Amaral

Subject: Physical Sciences, Quantum Science And Technology Keywords: Quantum Communications; Quantum Internet; Quantum Repeater Architectures; Satellite Optical Communications; Best-Path Estimation

Online: 27 February 2024 (14:13:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0850.v1

Combined Experimental and Numerical Modelling of the Electrical Behaviour of Laser Soldered Steel Sheets

Andor Körmöczi, Gábor Horváth, Tamás Szörényi, Zsolt Geretovszky

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: laser soldering; filler material; lap geometry; electrical measurement; numerical modelling

Online: 13 May 2024 (11:54:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1139.v3

The Aether Physics Model: A Novel Framework for Unifying Quantum Mechanics and General Relativity

David Thomson III, James Bourassa

Subject: Physical Sciences, Theoretical Physics Keywords: ; quantum aether; unified field theory; singularity; string theory; Gforce; chronovibration; quantum gravity; dark matter; the hierarchy problem ;

Online: 30 July 2024 (10:48:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0749.v1

Size Uniformity of CsPbBr3 Perovskite Quantum Dots via Manganese-Doping

Mi Zhang, Xue Han, Changgang Yang, Guofeng Zhang, Wenli Guo, Jialu Li, Zhihao Chen, Bin Li, Ruiyun Chen, Chengbing Qin, Jianyong Hu, Zhichun Yang, Ganying Zeng, Liantuan Xiao, Suotang Jia

Subject: Chemistry And Materials Science, Nanotechnology Keywords: CsPbBr₃ perovskite quantum dots; manganese-doping; size uniformity; single quantum-dot spectroscopy; narrow-linewidth

Online: 9 July 2024 (16:18:32 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202406.0518.v1

AssemblyQC: A NextFlow Pipeline for Reproducible Reporting of Assembly Quality

Usman Rashid, Chen Wu, Jason Shiller, Ken Smith, Ross Crowhurst, Marcus Davy, Ting-Hsuan Chen, Ignacio Carvajal, Sarah Bailey, Susan Thomson, Cecilia Deng

Subject: Biology And Life Sciences, Other Keywords: Genome; Quality assessment; Nextflow

Online: 10 June 2024 (06:39:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1688.v1

Primordial Black Holes in the Pre-Inflationary Period, the Probabilities of Their Occurrence Taking Into Account Quantum-Gravitational Corrections, and Some Cosmological Implications

Alexander Shalyt-Margolin

Subject: Physical Sciences, Theoretical Physics Keywords: keyprimordial black holes; inflationary cosmology; quantum-gravitational corrections

Online: 27 May 2024 (07:39:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0114.v4

The Cosmological Constant Problem and Quantum Spacetime Reference Frame

Min-Jie Luo

Subject: Physical Sciences, Quantum Science And Technology Keywords: cosmological constant problem; non-linear sigma model; quantum gravity

Online: 19 March 2018 (10:33:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1534.v1

Unbreakable SU(3) Atoms of Vacuum Energy: A Solution for Cosmological Constant Problem

Ahmed Farag Ali

Subject: Physical Sciences, Theoretical Physics Keywords: cosmological constant problem; mass-gap problem

Online: 23 May 2024 (12:42:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0116.v3

Network Analysis: A Novel Approach to Understand Suicidal Behavior

Derek de Beurs

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: suicide; network analysis; symptoms; personalized treatment

Online: 13 February 2017 (11:04:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.0767.v1

Agricultural and Technology-Based Strategies to Improve Water Use Efficiency in Arid and Semiarid Areas

Saif F. Alharbi, Mohammed Aldakil, Abrar Felemban, Ahmed Abdelrahim

Subject: Environmental And Earth Sciences, Soil Science Keywords: Water use efficiency; Agricultural water use; crop production; Agronomic practices

Online: 13 May 2024 (08:12:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1058.v1

Penrose Scattering in Quantum Vacuum

José Tito Mendonça

Subject: Physical Sciences, Optics And Photonics Keywords: Laser QED; scattering; nonlinear quantum vacuum

Online: 16 April 2024 (15:46:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0495.v1

Quantum Data Science: Leveraging Data Analytics for Advancing Quantum Computing

Koffka Khan

Subject: Computer Science And Mathematics, Computer Science Keywords: Quantum Computing; Data Science; Quantum Algorithms; Quantum Data Analysis; Quantum Error Correction

Online: 8 May 2024 (12:01:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0287.v3

A Theoretical Calculation of the Cosmological Constant Based on a Mechanical Model of Vacuum

Xiao-Song Wang

Subject: Physical Sciences, Thermodynamics Keywords: cosmological constant; dark energy; general relativity; electromagnetic aether; vacuum mechanics

Online: 20 September 2022 (10:27:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0024.v1

Normative Data for the D-KEFS Color-Word Interference and Trail Making Tests Adapted in Greek Adult Population 20–49 Years Old

Marianna Tsatali, Fotini Surdu, Andromachi Konstantinou, Despina Moraitou

Subject: Social Sciences, Psychology Keywords: D-KEFS; Color-Word Interference; executive functions; normative data; Trail Making Test

Online: 2 September 2024 (08:44:58 CEST)

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Background: This study was designed to adapt the Delis-Kaplan Executive System (D-KEFS) version of the Color-Word Interference (CWIT) and Trail making Tests (TMT) in Greek adult population from 20 to 49 years old, since it is of research as well as clinical importance to detect executive functions’ impairment in young adults with neurological or/and psychiatric conditions. Aims: Norms for the Greek adult population have been calculated to be available for neuropsychologists and health professionals who work in relevant settings. Methods: The study sample consisted of 101 healthy adults (41% male and 60% female), aged 20 to 49 years (M=32.16, SD=11.57) with education from 12 to 19 years of schooling (M=14.51, SD= .89). Pearson correlation test as well as chi square test were conducted to examine potential associations between gender, age, education, and participants’ performance. Afterwards, we calculated normative data using raw scores and transformed them to percentile scores. Finally, Greek norms were compared to the original raw scores, which were transformed in scaled scores by Delis et al. (2001). Results: The findings showed that age was the only variable which affected CWIT, whereas level of education as well as age were predictive factors for most TMT conditions, except for the visual scanning test (Condition 1). Gender did not affect both tests. Finally, D-KEFS norms for CWIT and TMT are available for Greek adult population to help clinicians detect executive functions’ deficits and therefore adjust tailored therapeutic strategies. Additionally, it is of great importance to use these tests for research purposes. Conclusion: Given that executive functions are assumed as high- level skills, which are highly related to everyday functionality, adapted tests contribute not only to assess the progression of any existing neurological as well as psychiatric disorders, but they can also be used to evaluate patients’ ability to live independently, as well as their access to work.

Preprint ARTICLE | doi:10.20944/preprints202409.1199.v1

A Soft Exoskeleton System Based-On Segmented Composite Proprioceptive Bending Actuators for Hand Rehabilitation ADL Tasks

Kai Li, Daohui Zhang, Yaqi Chu, Xingang Zhao, Shuheng Ren, Xudong Hou

Subject: Engineering, Bioengineering Keywords: Joint stiffness predicted; extension angle; Segmented Composite Proprioceptive Bending Actuators (SCPBAs); bending resistance; soft hand exoskeleton system

Online: 16 September 2024 (10:15:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1244.v1

Cavity-Induced Optical Nonreciprocity Based on Degenerate Two-Level Atoms

Chuanzhao Qi, Jiarui Zheng, Yuanhang Tong, Ruonan Li, Dan Wang, Lianghui Huang, Haitao Zhou

Subject: Physical Sciences, Optics And Photonics Keywords: optical nonreciprocity; single dark-state peak; degenerate two-level; strong-coupling

Online: 18 June 2024 (11:52:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2329.v1

Subclinical Left Ventricular Dysfunction over Seven-year Follow-up in Type 2 Diabetes Patients without Cardiovascular Diseases

Dariga Uaydinichna Akasheva, Tatyana Gennadyevna Utina, Olga Nikolaevna Dzhioeva, Oxana Mikhailovna Drapkina

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: type 2 diabetes; subclinical left ventricular dysfunction; diastolic disfunction; global longitudinal strain

Online: 30 July 2024 (07:04:33 CEST)

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Objective: Subclinical left ventricular disfunction (LVD) is common in asymptomatic patients with type 2 diabetes (T2D). Many patients with diabetes have an impaired diastolic and systolic function. With preserved ejection fraction LV (EFLV), the latter is defined as reduced global longitudinal strain (GLS), detected using the speckle-tracking echocardiography. This study is aimed to define the long-term structural and functional disorders of the LV myocardium in patients with T2D without CVD. Methods: Of the 120 patients with and without T2D of both sexes aged from 45 to 75 years (57.11±7.9 years), included in the study in 2012-2013, only 57 responded to the follow-up study. The patients were divided into two groups: one with T2D (n=29), the other without it, control (n=28). All patients underwent transthoracic two-dimensional echocardiography with assessment of standard indicators of systolic and diastolic cardiac function, as well as GLS. In addition, all participants underwent laboratory diagnostics of carbohydrate metabolism disorders markers, NT-proBNP and CRP. The median follow-up duration was 7.2 [7.0-7.8] years. Results: During the follow-up, a statistically significant increase in the incidence of diastolic dysfunction (DD) in the type 2 diabetes group was found from 53% to 61% (p = 0.004); no significant dynamics were noted in the control group (p = 0.48). The presence of T2D significantly increases the risk of developing DD (p=0.04). The presence of T2D, increased fasting glucose levels, and an increased HOMA index were independent predictors of the development of DD. Impairment of LVEF was not observed in both groups. At the same time, the proportion of patients with reduced GLS (< -18%) increased in the T2D group (p = 0.036). A significant difference in the frequency of decreased GLS depending on T2D was demonstrated. The presence of obesity, an increase in the HOMA index and an increase in CRP levels are independent predictors of impaired GLS. Conclusions: T2D is an independent risk factor for the worsening of subclinical left ventricular dysfunction in asymptomatic patients with T2D without CVD over 7-year follow-up. Diastolic dysfunction is represented by delayed relaxation of the LV myocardium; with preserved LVEF, reduced 2D GLS identifies systolic dysfunction. The tight control of glycemia, lipidemia, blood pressure and body weight is associated with the absence of poor clinical outcomes.

Preprint ARTICLE | doi:10.20944/preprints201811.0554.v1

Vacuum Condensate Picture of Quantum Gravity

Herbert W. Hamber

Subject: Physical Sciences, Particle And Field Physics Keywords: nonperturbative quantum gravity; regge-wheeler lattice path integral formulation; gravitational vacuum condensate

Online: 23 November 2018 (02:56:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0457.v3

The Mass-gap in Quantum Chromodynamics and a Restriction on Gluon Masses

S. A. Larin

Subject: Physical Sciences, Particle And Field Physics Keywords: Quantum Chromodynamics; gluon masses; renormalizability

Online: 27 April 2021 (12:37:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1260.v1

Dynamic Clustering and Scaling Behavior of Active Particles under Confinement

Matthew Becton, Jixin Hou, Yiping Zhao, Xianqiao Wang

Subject: Physical Sciences, Particle And Field Physics Keywords: active particles; simulation; aggregation; confined environment

Online: 18 December 2023 (08:16:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0173.v1

Cell Recruitment and the Origin of Anterior-Posterior Asymmetry in the Drosophila Wing

Rosalio Reyes, Rafael Rodriguez-Muñoz, Marcos Nahmad

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Drosophila wing; Anterior-Posterior; cell recruitment; asymmetry; morphometrics

Online: 2 April 2024 (16:19:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0566.v1

Loss Control-Based Key Distribution Under Quantum Protection

Nikita Kirsanov, Valeria Pastushenko, Aleksei Kodukhov, Aziz Aliev, Michael Yarovikov, Daniel Strizhak, Ilya Zarubin, Alexander Smirnov, Markus Pflitsch, Valerii Vinokur

Subject: Physical Sciences, Quantum Science And Technology Keywords: quantum key distribution; optical fiber; Rayleigh scattering; loss control; transmittometry; optical time-domain reflectometry; line tomography, privacy amplification.

Online: 11 March 2024 (04:32:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1807.v1

Concrete Decisions: How Psychological Distance Influences Willingness to Engage in Risky COVID Behavior

Ceridwen Williams, Paul Rauwolf, Matt Boulter, John A. Parkinson

Subject: Social Sciences, Behavior Sciences Keywords: Psychological distance; Construal level; Behavior Change; Covid-19

Online: 29 April 2024 (11:50:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0038.v1

The Cosmological OTOC: Formulating New Cosmological Micro-Canonical Correlation Functions for Random Chaotic Fluctuations in Out-of-Equilibrium Quantum Statistical Field Theory

Sayantan Choudhury

Subject: Physical Sciences, Quantum Science And Technology Keywords: Theoretical Cosmology; Quantum Chaos in Cosmology; Random Quantum Correlation in Cosmology; Quantum Correlation at Out-of-equilibrium

Online: 3 July 2020 (12:24:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0571.v1

Enhancing Extractable Quantum Entropy in Vacuum-Based Quantum Random Number Generator

Xiaomin Guo, Ripeng Liu, Pu Li, Chen Cheng, Mingchuan Wu, Yanqiang Guo

Subject: Physical Sciences, Quantum Science And Technology Keywords: quantum random number; vacuum state; maximization of quantum conditional min-entropy

Online: 24 October 2018 (11:22:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1345.v1

Feasibility Assessment of Implementing Semi-interlocking Masonry As Infill Panels in Framed Building Construction

Md Akhtar Hossain, Yuri Z. Totoev, Mark John Masia

Subject: Engineering, Civil Engineering Keywords: Semi-Interlocking Masonry (SIM); Mortarless Masonry; Infill panel; Energy Dissipation

Online: 21 June 2024 (05:11:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1791.v1

Organizational Citizenship Behavior and Employees’ Behavior: Mediated Role of Employees Brand Knowledge in Hotels

Nael Mosa Sarhan, Ghadeer AL Kateb, Eyad Shammout

Subject: Arts And Humanities, Humanities Keywords: Organizational Citizenship Behavior; Employees’ Behavior; Employees Brand Knowledge; Hotels

Online: 26 August 2024 (06:54:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1882.v1

Is Short-Read 16S rRNA Sequencing of Oral Microbiome Sampling a Suitable Diagnostic Tool for Head and Neck Cancer?

Kenny Yeo, Fangmeinuo Wu, Runhao Li, Eric Smith, Peter-John Wormald, Rowan Valentine, Alkis Psaltis, Sarah Vreugde, Kevin Fenix

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: oral microbiome; 16S ribosomal RNA; saliva; oral rinse; head and neck cancer

Online: 27 August 2024 (15:31:52 CEST)

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The oral microbiome, studied by sampling the saliva or oral rinse, has been long thought to have diagnostic capacity for head and neck cancers (HNC). However, previous reports on the HNC oral microbiome provide inconsistent results. The aim of this study is to consolidate these datasets and determine the oral microbial composition between HNC patients to healthy and premalignant individuals. We analyzed 16 published head and neck cancer (HNC) short-read 16S rRNA sequencing datasets, specifically targeting the V3V4, V4 and V4V5 regions. These datasets included saliva and oral rinse samples from donors with HNC, as well as from healthy and premalignant donors. Differences in diversities and microbial abundance were determined. HNC saliva displayed lower alpha diversity than healthy donors. In contrast, the opposite trend was observed for oral rinse samples. Beta diversity were largely similar across different patient types. Similar oral phyla were detected for all samples, but proportions were largely dependent on sample type (i.e. saliva or oral rinse) and primer set utilised for 16S rRNA sequencing. Neisseria, Leptotrichia and Megasphaera were elevated in healthy saliva, while Mycoplasma was elevated in HNC saliva. Oral rinse and saliva displayed similar enrichment for Fusobacterium, while Veillonella, Alloprevotella, and Campylobacter had conflicting results. The sparse partial least squares discriminant analysis model performed effectively in discriminating HNC from healthy or premalignant patients using V3V4 saliva (AUC = 0.888), and V3V4 oral rinse (AUC = 0.928), while poor discriminative capacity was observed for V4 saliva (AUC = 0.688). In conclusion, our meta-analysis highlighted the limitations of 16S rRNA sequencing, particularly due to variations across study batches, primer sets (i.e. V3V4, V4), and sample types. Hence, caution should be exercised when interpreting 16S rRNA sequencing results across studies, especially when different primer sets and sample types are used.

Preprint ARTICLE | doi:10.20944/preprints202405.1342.v1

Making the Research and Innovation Ethical: A Conceptual Framework for Ethics Assessment of Nanotechnology Innovations

Skanthesh Lakshmanan, Vinayak Padikkal Varyam, Oriparambil Sivaraman Nirmal Ghosh

Subject: Social Sciences, Other Keywords: nanoethics; technology assessment; ethical space; mycotoxin

Online: 21 May 2024 (04:59:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0339.v1

Analysing Temporal Evolution of OpenStreetMap Waterways Completeness in a Mountain Region of Portugal

Elisabete Monteiro, Glória Patrício

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: completeness; waterway; VGI; OpenStreetMap

Online: 6 June 2024 (07:20:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0007.v1

A Unified Force Theory Based on Quantum Aether Dynamics: Predictions and Experimental Support

David Thomson, James Bourassa

Subject: Physical Sciences, Theoretical Physics Keywords: unified force theory; quantum aether; distributed charge; fundamental forces; dimensional analysis

Online: 2 September 2024 (08:44:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0113.v5

Reconciling the Cosmological Constant with the Energy Density of Quantum Field Theories of the Zeropoint

Remi Cornwall

Subject: Physical Sciences, Quantum Science And Technology Keywords: Zeropoint Energy; Cosmological Constant; Stress Energy Tensor; Einstein Field Equations; Standard Model; Dark Energy; Quantum Gravity

Online: 31 March 2022 (14:01:14 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.0336.v1

Nano(bio)materials Do Not Affect Macrophage Phenotype – A Study Conducted by the REFINE Project

Christopher A.W. David, Jolanda P. Vermeulen, Sabrina Gioria, Rob J. Vandebriel, Neill J. Liptrott

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Monocyte-derived macrophages; Nanostructured lipid carrier; Polymeric nanomedicine; Immunotoxicity assessment

Online: 7 May 2024 (08:17:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0576.v1

A Vacuum of Quantum Gravity That is Ether.

Sergey L. Cherkas, Vladimir L. Kalashnikov

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: quantum gravity; vacuum state; vacuum energy,; eicheon

Online: 24 May 2021 (15:06:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.0242.v1

Environmental Law Reform Needed to Manage Trade of Australia’s Threatened Marine Species

Rosa Mar Dominguez-Martinez, Leslie Roberson, Jessica Gephart, Chris Wilcox, Glenn Sant, Carissa Klein

Subject: Environmental And Earth Sciences, Environmental Science Keywords: seafood sustainability; marine policy; biodiversity conservation; seafood trade; international trade; threatened species

Online: 3 April 2024 (16:31:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1442.v1

Revalidation of DNA Fragmentation Analyses for Human Sperm—Measurement Principles, Comparative Standards, Calibration Curve, Required Sensitivity, and Eligibility Criteria for Test Sperm—A Step-by-Step Approach to Cohort Studies with Multivariable Analyses

Satoru Kaneko, Yuki Okada

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: DNA fragmentation; single-cell pulsed-field gel electrophoresis; human sperm; sperm chromatin structure assay; sperm chromatin dispersion test; comet assay; quantitative analysis

Online: 23 May 2024 (08:19:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1582.v1

An Overview of the Arguments in Literature, For and Against the Use of Green Hydrogen for the Production of Direct Reduced Iron

Göran Roos

Subject: Business, Economics And Management, Business And Management Keywords: Green hydrogen; Direct Reduced Iron (DRI); Decarbonisation; Steel industry; Carbon Capture and Storage (CCS); Renewable energy; Electrolysis; Energy efficiency; Geopolitical implications; Social acceptance

Online: 23 May 2024 (16:45:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0042.v3

Visualizing Electromagnetic Vacuum by MRI

Chandrika S. Chandrashekar, Annadanesh Shellikeri, S. Chandrashekar, Erika A. Taylor, Deanne M. Taylor

Subject: Physical Sciences, Applied Physics Keywords: electromagnetic vacuum; MRI; metal

Online: 10 December 2016 (08:32:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0562.v1

On the Evaluation of Vacuum Energy Density in Quantum Field Theory

Ervin Goldfain

Subject: Physical Sciences, Particle And Field Physics Keywords: zero-point energy density; vacuum energy density; Standard Model parameters; mass spectrum; Renormalization Group flow; Higgs mechanism; cosmological constant problem

Online: 27 January 2021 (13:11:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0217.v1

Bacterial and Genetic Features of Raw Retail Pork Meat: Integrative Analysis of Antibiotic Susceptibility, Whole Genome Sequencing and Metagenomics

Michelle Lowe, Wilhelmina Strasheim, Wai Yin Chan, Olga Perovic

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: whole genome sequencing; metagenomics; antibiotic residue testing; retail pork meat; South Africa

Online: 2 July 2024 (14:50:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0884.v1

Recent Advances in Graphene Adaptive Thermal Camouflage Devices

Lucia Sansone, Fausta Loffredo, Fabrizia Cilento, Riccardo Miscioscia, Alfonso Martone, Nicola Barrella, Bruno Paulillo, Alessio Bassano, Fulvia Villani, Michele Giordano

Subject: Engineering, Electrical And Electronic Engineering Keywords: Camouflage; Nanomaterials; Emissivity; Infrared

Online: 11 July 2024 (08:29:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1140.v1

New Design Scheme and Application of Fresnel Lens for Broadband Photonics Terahertz Communication

Peng Tian, Yang Han, Weipin Li, XiongWei Yang, MingXu Wang, Jianjun Yu

Subject: Engineering, Telecommunications Keywords: terahertz wireless transmission; plano-convex lens; Fresnel lens; PTFE

Online: 14 September 2024 (11:37:43 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202407.0251.v1

Generalized n-dimensional Effective Temperature for Cryogenic Systems in Accelerator Physics

Heetae Kim, Chang-Soo Park

Subject: Physical Sciences, Quantum Science And Technology Keywords: effective temperature; fractional dimension; thermal radiation; cryogenic system; accelerator physics

Online: 2 July 2024 (14:03:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0060.v1

Structural Optimization in Building Information Modeling (BIM) Projects Using Visual Programming, Evolutionary Algorithms, and Sustainability Assessment Tools

Feyzullah Yavan, Reza Maalek, Vedat Toğan

Subject: Engineering, Architecture, Building And Construction Keywords: Structural Optimization; Genetic Algorithm; Parametric Design; Visual Programming; Generative Modeling

Online: 2 April 2024 (12:41:38 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202407.0921.v1

Phage Anti-Pycsar Proteins Efficiently Degrade β-Lactam Antibiotics

Pallav Joshi, Stefan Krco, Samuel J Davis, Lachlan Asser, Thomas Brück, Rochelle M Soo, Mikael Bodén, Philip Hugenholtz, Liam A Wilson, Gerhard Schenk, Marc T Morris

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Virus; Metallo-beta-lactamase (MBL); MBL-fold superfamily; antimicrobial resistance; anti-Pycsar; carbapanemase

Online: 11 July 2024 (04:52:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0952.v2

Interpreting Diastolic Dynamics and Evaluation Through Echocardiography

Xiaoxiao Zhang, Ke Li, Cristiano Cardoso, Angel Moctezuma-Ramirez, Abdelmotagaly Elgalad

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: diastolic dynamics; echocardiography evaluation; diastolic dysfunction; stress echocardiography; strain imaging; integrating artificial intelligence

Online: 31 May 2024 (12:25:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0628.v1

Some String Cosmological Models in Bianchi Type III Space-Time with Magnetic Field and Vacuum Energy Density

Raj Bali, Subhash Bola

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: String, Cosmological, Bianchi Type III, Magnetic Field, Vacuum Energy Density.

Online: 30 November 2018 (10:13:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2039.v1

Assessment of Hygroscopic Behavior of Arctic Aerosol by contemporary Lidar and Radiosonde Observations

Nele Eggers, Sandra Graßl, Christoph Ritter

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Arctic Aerosol; Lidar; hygroscopic growth

Online: 25 July 2024 (12:05:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1374.v1

Elucidating the z-dependence of the MOND acceleration (a₀) within the Scale Invariant Vacuum (SIV) paradigm

Vesselin G. Gueorguiev

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: cosmology – dark matter – cosmological parameters – cosmology; theory

Online: 19 September 2024 (07:35:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1220.v1

Cervical Cancer Perceived Risk Factors Behavior Using Logistic Regression Technique

Aya Haraz, I.M. Elzein, Ashraf Chamseddine, Ahmed H. Eltanboly

Subject: Engineering, Bioengineering Keywords: Principal component analysis; cervical cancer; behavioral risk factor; logistic regression (LR); feature engineering; regularization ;

Online: 21 March 2024 (02:00:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1547.v1

Time Series Forecasting with Missing Values Using Multiple Models: An Application to Wind Energy Systems

Xiaoou Li

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: time series forecasting; ARIMA; neural networks; transfer learning; wind energy systems

Online: 28 February 2024 (11:27:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.0860.v1

Seeking a Treatable Cause of Cardiac Arrest During and After Resuscitation

Saleem M. Halablab, William Reis, Benjamin S. Abella

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: out of hospital cardiac arrest; resuscitation; diagnosis; computed tomography; ultrasonography; electrocardiography; coronary angiography; serum biomarkers

Online: 13 August 2024 (17:02:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0194.v1

Determination of Nine Fentanyl and Six Amphetamine Drugs in Hair Samples by GC-MS/MS and LC-MS/MS

Qi Wei, Fuhai Su

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Fentanyl; Amphetamine; Hair samples; Reference material; GC-MS/MS; LC-MS/MS

Online: 3 September 2024 (07:30:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0673.v1

Production and Characterization of biochar produced from Slow Pyrolysis of Teff-Husk

Marcin Landrat, Mamo Abawalo, Krzysztof Pikoń, Paulos Fufa

Subject: Engineering, Bioengineering Keywords: biomass; teff husk; slow pyrolysis; biofuel; biochar; TGA; FTIR; SEM; EDX

Online: 12 March 2024 (08:08:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0690.v1

Strategic Intelligence: A Semantic Leadership Perspective

Dan Paiuc, Adina Săniuță, Alina Mirela Teacu Parincu

Subject: Business, Economics And Management, Business And Management Keywords: strategic intelligence; leadership; neuroleadership; global management; cultural intelligence; knowledge dynamics.

Online: 10 April 2024 (12:04:01 CEST)

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Strategic intelligence covers the examination of what impacts and influences the business and the related SWOT analysis, (strengths, weaknesses, opportunities, and threats mapping). Through this research, leaders will be able to properly allocate and re-route resources, identify areas of improvement, and ensure that strategic initiatives are aligned with the organization's mission. Strategic intelligence is, therefore, effective through the use of critical thought and data-driven decisions and seeing the outcomes of different positioned alternatives. It must also form and support a culture of cooperation and open communication within the organizations, stimulating employees' inputs and learning curves. The article's subject is the necessity for strategic intelligence, a crucial competence for leaders, managers, and companies striving to remain competitive, to be utilized and best leveraged in today's volatile and dynamic business contexts. It helps the leadership turn proactive, foresee trends, and make correct, agile decisions that enforce companies' long-term growth and success. This study follows a research design that includes a thorough literature review and bibliometric research, executed via VoSViewer, illustrating the concept of strategic intelligence from a leadership point of view as a driver of competitive advantage. Further, the article points out that the limitations are acknowledged because the literature on the matter is limited, as strategic intelligence is relatively new to the business sector; moreover, more research is required to fully understand and use the potential of strategic intelligence in business growth. By overcoming these limitations and continuing to study this concept, businesses can gain a competitive edge and make informed decisions that fuel their success in an ever-evolving market. As a result, this study contributes to developing strategic intelligence in leadership and business and paves the road for further research and applications of strategic intelligence theories in organizational contexts.

Preprint ARTICLE | doi:10.20944/preprints202303.0338.v1

On the Cosmic Evolution of the Quantum Vacuum Using Two Variable G Models and Winterberg's Thesis

Christopher Pilot

Subject: Biology And Life Sciences, Horticulture Keywords: Winterberg model; Planck particles; positive and negative mass Planck particles; planckions; quantum vacuum; space as a superfluid/ supersolid; extended models for space; cosmological constant; Higgs field as a composite particle; Higgs boson; inherent length scale for the vacuum; dark energy; cosmological scaling behavior for the quantum vacuum; variable G models; extended gravity; Newton’s constant as an order parameter; high energy behavior for the vacuum

Online: 20 March 2023 (03:40:46 CET)

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We work within a Winterberg framework where space, i.e., the vacuum, consists of a two component superfluid/super-solid made up of a vast assembly (sea) of positive and negative mass Planck particles, called planckions. These material particles interact indirectly, and have very strong restoring forces keeping them a finite distance apart from each other within their respective species. Because of their mass compensating effect, the vacuum appears massless, charge-less, without pressure, net energy density or entropy. In addition, we consider two variable models, where, , is Newton’s constant, and, , increases with an increase in cosmological time. We argue that there are at least two competing models for the quantum vacuum within such a framework. The first follows a strict extension of Winterberg’s model. This leads to nonsensible results, if increases, going back in cosmological time, as the length scale inherent in such a model will not scale properly. The second model introduces a different length scale, which does scale properly, but keeps the mass of the Planck particle as, the Planck mass. Moreover we establish a connection between ordinary matter, dark matter, and dark energy, where all three mass densities within the Friedman equation must be interpreted as residual vacuum energies, which only surface, once aggregate matter has formed, at relatively low temperatures. The symmetry of the vacuum will be shown to be broken, because of the different scaling laws, beginning with the formation of elementary particles. Much like waves on an ocean where positive and negative planckion mass densities effectively cancel each other out and form a zero vacuum energy density/ zero vacuum pressure surface, these positive mass densities are very small perturbations (anomalies) about the mean. This greatly alleviates, i.e., minimizes the cosmological constant problem, a long standing problem associated with the vacuum.

Preprint ARTICLE | doi:10.20944/preprints202402.1299.v1

Advancements in Quantum Computing and AI May Impact PQC Migration Timelines

Dr. Robert Campbell, Dr. Whitfield Diffie, Charles Robinson

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Post-quantum cryptography (PQC), PQC transition timelines, hybrid quantum-classical computing, artificial intelligence, machine learning, deep learning, Grover's Adaptive Search (GAS), Harrow-Hassidim-Lloyd (HHL) Algorithm

Online: 22 February 2024 (11:54:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0032.v1

Transcranial Direct Current Stimulation: Effects on Motor and Non-Motor Symptoms of Parkinson's Disease

Fayda Protásio, Carlos Tomaz, Joaquim Brasil-Neto, Pedro Brandão, Nasser Allam, Maria Clotilde Henriques Tavares

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: Parkinson’ s disease; neuromodulation; transcranial direct current stimulation – tDCS; movement disorders; mood; sleep; cognition

Online: 1 April 2024 (09:56:57 CEST)

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Abstract Introduction: In the last thirty years, brain neuromodulation techniques have been used as an alternative to pharmacological treatment of neurological disorders. Parkinson's disease (PD) is a neurodegenerative disorder leading to bradykinesia, rest tremor, postural changes, and non-motor symptoms such as depression, anxiety, sleep disorders, pain, and cognitive decline that compromises executive functions (EFs), responsible for the orderly execution of behaviors and tasks of daily life and intentional and directed actions. To this date, a few studies with transcranial direct current stimulation (tDCS) have shown beneficial effects in PD patients concerning specific motor and non-motor symptoms, targeting the motor cortex and/or prefrontal regions. Objective: The main objective of this study was to evaluate the effects of left prefrontal tDCS across a broad spectrum of motor and non-motor symptoms of PD using established validated scales. Method: Single-blind randomized clinical trial with 18 volunteers with PD, aged between 45 and 80 years (66.1 ± 9.65), who met inclusion and exclusion criteria. Participants were submitted to assessments of motor and non-motor functions employing psychometric scales and tests to evaluate EFs and were randomly divided into two groups: control (sham stimulation) and experimental (active stimulation). All participants were involved in three separate tDCS sessions. The anode was positioned over the left dorsolateral prefrontal cortex and the cathode over the right supraorbital region, with a direct current intensity of 2mA, lasting 20 minutes. At the end of the three sessions, all participants were reassessed. Results: Significant effects of tDCS on non-motor functions were observed for cognition (verbal fluency of actions, clock copy test, appointment by visual confrontation, and verbal memory with immediate free recall) and subjective assessment of sleep quality (overall restlessness and discomfort in the arms and legs at night, leg and arm cramps at night and distressing dreams). There was also an improvement in the rate of errors and successes for congruent and incongruent stimuli of the Stroop Test. The beneficial effects on motor function were decreased rigidity, improved gait, and greater agility in the finger-tapping test. Conclusion: Three tDCS sessions showed positive results for participants with PD, producing significant improvements in various motor and non-motor functions, including sleep quality, cognition, and EFs. Additionally, the present results indicate that tDCS neuromodulation of the left dorsolateral prefrontal cortex region is feasible, safe, and provides significant objective benefits for PD patients.

Preprint ARTICLE | doi:10.20944/preprints202408.0843.v1

Improving the Decision-Making for Sustainable Demolition Waste Management by Combining a BIM-Based Life Cycle Sustainability Assessment Framework and Hybrid MCDA Approach

Dongchen Han, Abbas Rajabifard

Subject: Engineering, Civil Engineering Keywords: C&; DWM; recycling; BIM; MCDA; sustainability assessment; LCA

Online: 13 August 2024 (07:49:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0114.v1

Volunteering as Meaningful Activity for People Living with Young Onset Dementia: A Thematic ‘Co-Analysis’

Rose E Vincent, Rosalie Ashworth, Irene Donaldson, Julie Hayden, Gerald King, Chris Maddocks, Keith Oliver, Martin Robertson, Tom C Russ, Heather Wilkinson

Subject: Social Sciences, Sociology Keywords: volunteering; post-diagnosis; young-onset dementia; early-onset dementia; meaningful activity; purpose; co-production

Online: 2 May 2024 (09:47:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0643.v1

Phytophthora Communities Associated with Agathis australis (kauri) in Te Wao Nui o Tiriwa/Waitākere Ranges, New Zealand

Shannon Hunter, Ian Horner, Jack Hosking, Ellena Carroll, Jayne Newland, Matthew Arnet, Nick Waipara, Bruce Burns, Peter Scott, Nari Williams

Subject: Biology And Life Sciences, Other Keywords: Phytophthora; Agathis australis; kauri dieback; community structure; soil baiting; metabarcoding; New Zealand; epidemiology; invasive pathogen; forest management

Online: 11 March 2024 (18:00:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1213.v1

Aquatic Insects (Ephemeroptera, Plecoptera and Trichoptera) metric as important tool in Water Quality Assessment in hilly and mountain streams

Bojana Tubić, Stefan Andjus, Katarina Zorić, Božica Vasiljević, Katarina Jovičić, Jelena Čanak Atlagić, Momir Paunović

Subject: Biology And Life Sciences, Life Sciences Keywords: Aquatic insects; EPT group; diversity; biological indices; water quality assessment; hilly and mountain streams; Serbia

Online: 21 February 2024 (10:05:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1833.v1

Factors Associated With Sexual Initiation Amongst Adolescents 10–15 Years in Jamaica

Georgiana Gordon-Strachan, Helen K Fox, Abigail Harrison, Andriene Grant, Shelly R McFarlane

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: adolescents; sexual initiation; resiliency factors; risk factors

Online: 27 June 2024 (06:14:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0334.v1

The Autophagic Activator GHF-201 can Alleviate Pathology in a Mouse Model and in Patient Fibroblasts of Type III Glycogenosis

Kumudesh Mishra, Sahar Sweetat, Saja Baraghithy, Uri Sprecher, Monzer Marisat, Sultan Bastu, Hava Glickstein, Joseph Tam, Hanna Rosenmann, Miguel Weil, Edoardo Malfatti, Or Kakhlon

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: glycogen; glycogen storage disease type III; pharmacotherapy

Online: 6 June 2024 (07:54:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0111.v1

Stakeholders’ Perception on National Heatwave Plans and Their Local Implementation in Belgium and The Netherlands

Joris Adriaan Frank Van Loenhout, José Manuel Rodriguez-Llanes, Debarati Guha-Sapir

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Heatwaves; health protection; perception; key informant interviews

Online: 26 October 2016 (09:52:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0551.v1

Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre-post Intervention Study

Amelia McGuinness, Martin O'Hely, Douglas Stupart, David Watters, Samantha Dawson, Christopher Hair, Michael Berk, Mohammadreza Mohebbi, Amy Loughman, Glenn Guest, Felice Jacka

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Gut microbiota; colonoscopy; bowel preparation; depression; microbiota-gut-brain axis; mental health; psychiatry; gastroenterology. ;

Online: 11 March 2024 (09:45:31 CET)

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Objective: Mechanical bowel preparation is essential for the visualisation of the colon during colonoscopy, and previous studies have identified changes in gut microbiota composition after bowel preparation and colonoscopy. Considering the gut microbiota is increasingly implicated in mood, we aimed to explore the potential impact of this intervention on mood and the microbiota-gut-brain axis. Methods: We conducted a pre-post intervention study, with timepoints of one week before and one month after bowel preparation and colonoscopy, in community-dwelling adults referred for colonoscopy. Our primary outcome was change in average Hospital Anxiety and Depression Scale depression sub-scores using generalised estimating equations. We also examined changes in average anxiety, stress, and quality of life scores, and faecal microbiota composition and potential function using 16S rRNA sequencing. We further explored associations between changes in depressive symptoms and the gut microbiota and conducted post-hoc analyses to explore potential effect modifiers. Key Results: 59 participants were included in the analyses. Depressive symptoms decreased one-month post-procedure compared to baseline (adjusted β=−0.64; 95%CI: −1.18, −0.11). Irritable bowel syndrome (IBS) appeared to moderate this relationship (1.78; 0.292, 3.26); depressive symptoms increased in those with, and decreased in those without, IBS. Changes in gut microbiome composition included reduced alpha diversity, modest effects on beta-diversity, and increases in genera associated with potential health benefits, one-month post-procedure compared to baseline. Increases in the CLR-transformed abundance of Ruminococcaceae UCG-009 were associated with improvements in depressive symptoms. Conclusions: There is preliminary evidence of a potential mental health effect of bowel preparation and colonoscopy, which may be associated with changes to the gut microbiota. There may also be a differential mental health impact of this procedure for those with and without IBS. Considering the limitations of our study, further research is required to confirm these findings and their clinical relevance.

Preprint ARTICLE | doi:10.20944/preprints202403.0412.v1

Human Leukocyte Antigen-Allelic Variations May Influence the Age at Cancer Diagnosis in Lynch Syndrome

Lutricia Ndou, Ramadhani Chambuso, Ziyaad Valley-Omar, George Rebello, Paul Goldberg, Adam Boutall, Ursula Algar, Raj Ramesar

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Lynch syndrome; colorectal cancer; germline pathogenic variant MLH1:c.1528C>; T; Human leukocyte antigen (HLA); age at cancer diagnosis; genetic risk modifiers; personalized cancer screening

Online: 7 March 2024 (07:36:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.0590.v1

Metabolic Syndrome in Patients With Epilepsy

Željka Petelin Gadže, Asja Hodžić, Biljana Đapić Ivančić, Andreja Bujan Kovač

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Metabolic syndrome; Epilepsy; Dyslipidemia; Antiepileptic drugs

Online: 11 June 2024 (08:50:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1169.v1

Microbead-encapsulated luminescent bioreporter screening of P. aeruginosa via its secreted quorum sensing molecules.

Abraham Abbey Paul, Yael Schlichter Kadosh, Ariel Kushmaro, Robert S. Marks

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Alginate; Hydrogels; quorum sensing; , C4-HSL; whole-cell biosensors; Furanone C-30; autoinducers; Pseudomonas aeruginosa,; bioencapsulation

Online: 18 June 2024 (11:54:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1215.v1

Evaluating the VIIRS Imagery for Developing Near Real-Time Nationwide Vegetation Cover Monitoring in Indonesia

Yudi Setiawan, Kustiyo Kustiyo, Sahid Agustian Hudjimartsu, Judin Purwanto, Riva Rovani, Anna Tosiani, Basyiruddin Usman, Tatik Kartika, Novie Indriasari, Lilik Budi Prasetyo, Belinda Arunarwati Margono

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: change detection; temporal vegetation dynamics; open area index; multi temporal VIIRS

Online: 18 April 2024 (10:57:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0816.v1

Securing the Internet of Things (IoT) in the Quantum Era: Challenges and Future Directions for Quantum-Resistant Cryptography

Maryam Alwashahi, Hothefa Jassim, fadi Abdelfattah

Subject: Computer Science And Mathematics, Security Systems Keywords: quantum computing; post-quantum cryptography; IoT; lattice-based cryptography; code-based cryptography; multivariate cryptography; and hash-based signatures

Online: 12 August 2024 (13:30:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0231.v1

Transcriptomic Analysis across Crayfish (Cherax quadricarinatus) Claw Regeneration Reveals Potential Stem Cell Sources for Cultivated Crustacean Meat

Lisa Musgrove, Avani Bhojwani, Cameron Hyde, Susan Glendinning, Josephine Nocillado, Fraser D. Russell, Tomer Ventura

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: cultivated crustacean meat; limb regeneration; stem cells; RNA-Seq; cell proliferation; muscle development; differential gene expression

Online: 3 July 2024 (04:19:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0707.v1

Associations among Beliefs Supporting Patriarchal Principles, Conflict Avoidance, and Economic Violence in Intimate Partner Relationships of Ultraorthodox Jews

Ruth Berkowitz, David Mehlhausen-Hassoen, Zeev Winstok

Subject: Social Sciences, Behavior Sciences Keywords: patriarchal principles; conflict avoidance; economic violence; intimate partner violence

Online: 10 September 2024 (08:00:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0182.v1

Hybrid Genetic Algorithm and Tabu Search for Solving Preventive Maintenance Scheduling Problem for Cogeneration Plants

Khaled Alhamad, Yousif Alkhezi

Subject: Computer Science And Mathematics, Discrete Mathematics And Combinatorics Keywords: preventive maintenance; scheduling; optimization; genetic algorithm; tabu search; metaheuristic

Online: 2 April 2024 (12:56:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0639.v1

Less Is More: Higher Skilled Sim Racers Allocate Significantly Less Attention to Track Relative to Display Features Than Lower Skilled Sim Racers

John Joyce, Mark J. Campbell, Fazilat Hojaji, Adam J. Toth

Subject: Social Sciences, Cognitive Science Keywords: Esports; Gaming; Expertise; Gaze behaviour; Attentional control

Online: 12 February 2024 (05:45:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1326.v1

Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study

Natalya Starodubtseva, Vitaliy Chagovets, Alisa Tokareva, Madina Dumanovskaya, Evgenii N. Kukaev, Anastasia Novoselova, Vladimir Frankevich, Stanislav V. Pavlovich, Gennady Tikhonovich Sukhikh

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: lipid; endometriosis; dried blood spot; mass-spectrometry; diagnostic

Online: 21 May 2024 (17:22:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1767.v1

Associations of Serum Levels of cGAMP in the Context of COVID-19 Infection, Atherosclerosis, Sterile Inflammation, and Functional Endothelial Biomarkers in Patients With Coronary Heart Disease and Healthy Volunteers

Nadezhda G. Gumanova, Natalya L Bogdanova, Yaroslav I. Havrichenko, Alexander U. Gorshkov

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; serum biomarkers; sterile inflammation; serum cGAMP; serum nitrite and nitrate (NOx); endothelin-1; endothelial dysfunction; SCORE; atherosclerosis

Online: 26 June 2024 (12:29:59 CEST)

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Abstract: Background: COVID-19 is associated with various changes in immunity, including signaling through the pattern-recognition receptors (PRR). However, the role of these processes is poorly understood. The present study aimed to evaluate the relationships of the serum levels of the cyclic dinucleotide 2’3’-cyclic GMP-AMP (cGAMP) marker of PRR activation with immunoglobulin G antibodies against severe acute respiratory syndrome-linked coronavirus (IgG-SARS)-positive status and endothelial dysfunction in apparently healthy subjects and in patients with coronary heart disease (CHD). Methods: The present study investigated selected groups from two cohorts, including cohort 1 of 307 healthy volunteers and cohort 2 of 218 CHD patients. COVID-19 infection was confirmed by the detection of IgG-SARS against SARS-CoV-2 S1 protein receptor-binding domain. Cohort 1 (24–69 years of age; 44.8 ± 8.6 years; 80.4% men) was examined for systematic coronary risk evaluation by European Society of Cardiology (SCORE) starting from 2019 before the onset of the COVID-19 pandemic. Cohort 2 (63±10.9 years of age, 54% men) was processed starting from 2017 (three years prior to the COVID-19 pandemic) in a hospital setting to undergo coronary angiography to assess coronary lesions as Gensini score. The levels of cGAMP and endothelial markers (nitrate and nitrite combined as NOx and endothelin-1) were assessed in the serum to evaluate the associations with IgG-SARS status, SCORE, and extent of coronary lesions by correlation and receiver operating characteristic (ROC) analyses. Results: Serum cGAMP did not discriminate between SARS-positive and SARS-negative healthy subject of cohort 1. Moreover, the level of cGAMP was not associated with endothelial biomarkers in healthy subjects. However, serum cGAMP was associated with atherosclerosis in cohort 2 in patients with CHD (area under the curve (AUC) 0.69; 95% CI 0.587-0.806; P=0.001), indicating that serum cGAMP was lower in patients with coronary stenosis compared to that in patients without coronary lesions. Conclusions: Low levels of serum cGAMP were associated with atherosclerosis and markers of endothelial dysfunction in patients with CHD. However, cGAMP was not associated with endothelial biomarkers or IgG-SASR immune status in healthy subjects, suggesting that cGAMP may be a new biomarker of coronary lesions in the context of sterile inflammation.

Preprint COMMUNICATION | doi:10.20944/preprints202402.0781.v1

Quantum Hydrodynamics: Theoretical Framework and Symmetries

Matthew James Stephenson

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: Decoherence; Quantum Systems; Mathematical Framework; System Configuration; Quantum Information Processing; Quantum Hydrodynamics; Field Theory; Ideal Quantum Gases

Online: 14 February 2024 (10:05:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1417.v1

Humanization of pan-HLA-DR mAb 44H10 Hinges on Critical Residues in the Antibody Framework

Audrey Kassardjian, Danton Ivanochko, Brian Barber, Arif Jetha, Jean-Philippe Julien

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: antibody humanization; framework regions; vernier zone; MHC class II targeting

Online: 22 May 2024 (14:46:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0001.v1

Optically Clear and Resilient Free-Form µ-Optics 3D-Printed via Ultrafast Laser Lithography

Linas Jonušauskas, Darius Gailevičius, Lina Mikoliūnaitė, Danas Sakalauskas, Simas Šakirzanovas, Saulius Juodkazis, Mangirdas Malinauskas

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: direct laser writing; ultrafast laser; 3D laser lithography; 3D printing; hybrid polymer; integrated microoptics; optical damage; photonics; pyrolysis; ceramic 3D structures

Online: 1 November 2016 (04:59:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.0661.v1

An Overview of the Immune Response to COVID-19 Vaccination and Strategies to Boost SARS-CoV-2 Immunity in People with Inborn Errors of Immunity

Emma Chang-Rabley, Menno C. van Zelm, Emily E. Ricotta, Emily S.J. Edwards

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19 vaccination; SARS-CoV-2-specific antibody therapies; immune memory; inborn errors of immunity; breakthrough infections; antibodies; memory B cells; memory T-cells; receptor-binding domain

Online: 10 May 2024 (11:42:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0162.v1

Effectiveness of Smartphone App for the treatment of Pediatric Obesity: A Prospective Longitudinal Study

Giuseppina Rosaria Umano, Mariapia Masino, Grazia Cirillo, Giulia Rondinelli, Francesca Massa, Giuseppe Salvatore R.C. Mangoni di Santo Stefano, Anna Di Sessa, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Pietro Buono

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: obesity 1; treatment 2; m-Health 3

Online: 2 August 2024 (12:58:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1793.v1

Challenges for Compliance with Industrial Effluent Regulations – the Industry Perspective

Zulaikha Mokhtar, Steven Kenway, Ilje Pikaar, Irdayanti Mat Nashir

Subject: Environmental And Earth Sciences, Other Keywords: Industry challenge; environmental compliance; continuous improvement; behavioral change; adaption of regulation

Online: 28 April 2024 (07:49:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1358.v1

A Pi-Theorem-Based Advanced Scaling Methodology for Similarity Assessment of Marine Shafting Systems

Georgios N. Rossopoulos, Christos I. Papadopoulos

Subject: Engineering, Marine Engineering Keywords: Pi-Theorem; dimensional analysis; marine shafting systems; journal bearing performance; comparative analysis; similarity assessment

Online: 19 April 2024 (15:56:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0033.v1

Raw Material Purchasing Optimization Using Column Generation

Zhen Gao, Danning Li, Danni Wang, Zengcai Yu

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Purchasing; optimization; MILP; column generation

Online: 1 May 2024 (16:46:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0058.v1

The Political Economy of Russian Migration Politics

Vladimir Malakhov, Mark Simon

Subject: Business, Economics And Management, Economics Keywords: labor migration; migration policy; Russia; Post-Soviet space; governmentality; labor legalization

Online: 18 September 2016 (09:45:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0002.v1

Mathematical and Experimental Research of the Shopping Centers’ Managers’ Strategic Behavior

Aleksandr Alekseev, Varvara Spirina, Aleksandra Andronova

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: experimental economy; mathematical game theory; experimental game theory; behavioral experiment; business game; shopping centers; property management

Online: 1 August 2018 (06:27:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1117.v1

Globospiramine Exhibits Inhibitory and Fungicidal Effects against Candida albicans via Apoptotic Mechanisms

Joe Anthony H. Manzano, Simone Brogi, Vincenzo Calderone, Allan Patrick G. Macabeo, Nicanor Austriaco

Subject: Biology And Life Sciences, Parasitology Keywords: globospiramine; bisindole alkaloid; Voacanga globosa; Candida albicans; Candida tropicalis; molecular docking; molecular dynamics; antifungal; apoptosis ;

Online: 17 April 2024 (08:30:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1016.v1

DNA Gene's Basic Structure as a Nonperturbative Circuit Quantum Electrodynamics: Is RNA Polymerase II the Quantum Bus of Transcription?

Raul Riera Aroche, Yveth M. Ortiz García, Esli C. Sánchez Moreno, José S. Enriquez Cervantes, Andrea C. Machado Sulbaran, Annie Riera Leal

Subject: Biology And Life Sciences, Biophysics Keywords: DNA gene's basic structure; circuit quantum electrodynamics; quantum bus of transcription

Online: 14 September 2024 (03:36:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0097.v1

Greek Norms for the D-kefs Verbal and Design Fluency Subtests in Adult Population between 20–49 Years Old

Marianna Tsatali, Andromachi Konstantinou, Fotini Surdu, Despina Moraitou

Subject: Social Sciences, Psychology Keywords: D-KEFS, design fluency, executive functions, normative data, verbal fluency

Online: 2 September 2024 (13:38:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2264.v1

Dietary Omega-3 PUFA Intake in Patients with Chronic Kidney Disease: The Association with Vitamin D Deficiency, Intima-Media Thickness and Blood Pressure

Danijela Ristic-Medic, Marija Takic, Biljana Pokimica, Brankica Terzic, Milica Kojadinovic, Toplica Lepic, Slavica Radjen, Vesna Vucic

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: omega-3; carotid intima-media thickness; chronic kidney disease; cardiovascular risk; hemodialysis

Online: 30 August 2024 (15:32:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1178.v1

Refraction-aware Structure-from-Motion for Airborne Bathymetry

Alexandros Makris, Vassilis C. Nicodemou, Evangelos Alevizos, Iason Oikonomidis, Dimitrios D. Alexakis, Anastasios Roussos

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: refraction-aware Structure-from-Motion; deep learning; shallow water bathymetry; drone imagery

Online: 19 June 2024 (13:31:34 CEST)

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