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Preprint REVIEW | doi:10.20944/preprints202408.1879.v3

A Comprehensive Review on Phage Therapy and Phage-Based Drug Development

Longzhu Cui, Shinya Watanabe, Kazuhiko Miyanaga, Kotaro Kiga, Teppei Sasahara, Yoshifumi Aiba, Xin-Ee Tan, Srivani Veeranarayanan, Kanate Thitiananpakorn, Huong Minh Nguyen, Dhammika Leshan Wannigama

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: bacteriophage; phage therapy; antimicrobial resistance; intracellular pathogen; biofilm generating pathogen; phage vector; antibacterial phage capsid; phage-based vaccines; phage-based medicine.

Online: 9 September 2024 (11:38:59 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202405.0088.v1

Severe Cases of Buruli Ulcer (Infection with Mycobacterium ulcerans) in Common Ringtail Possums in Victoria Are Adversely Affecting Animal Welfare

Emma C. Hobbs, Panos Loukopoulos, Timothy Stinear, Jessica Porter, Jean Lee, Pam Whiteley, Lee Skerratt, Katherine Gibney, Anna Meredith

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Animal welfare; Buruli ulcer; Mycobacterium ulcerans; possums; wild animals

Online: 2 May 2024 (12:04:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1132.v1

Bioactive Bioxanthracene and Cyclodepsipeptides from the Entomopathogenic Fungus Blackwellomyces roseostromatus BCC56290

Kunthida Phutthacharoen, Natalia Andrea Llanos-Lopez, Rita Toshe, Wasana Noisripoom, Artit Khonsanit, Janet Jennifer Luangsa-ard, Kevin D Hyde, Sherif S. Ebada, Marc Stadler

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Insect pathogen; Hypocreales; Ascomycota; beauveriolides

Online: 17 June 2024 (12:21:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0041.v1

Hunting the Cell Cycle Snark

Vic Norris

Subject: Biology And Life Sciences, Life Sciences Keywords: cell division; bacteria; hyperstructure; water; phase separation; condensate; origins of life; chromosome replication; phenotypic diversity; differentiation

Online: 1 August 2024 (12:38:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1756.v1

Malian children core gut mycobiome

Abdourahim Abdillah, Kodio Aly, Stéphane Ranque

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Fungal gut community structure; gut mycobiome; core mycobiome; ITS metabarcoding; children; Dogon country

Online: 29 February 2024 (17:02:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1061.v1

Enhancing Reliability in Wind Turbine Power Curve Estimation

Pere Marti-Puig, José Ángel Hernández, Jordi Solé-Casals, Moisès Serra-Serra

Subject: Engineering, Energy And Fuel Technology Keywords: Wind Power Curve Modeling; Artificial neural networks (ANN); Wind Turbine (WT); SCADA Data.; Industrial AI

Online: 19 February 2024 (12:24:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0662.v1

Meat-Borne-Parasite: A Nanopore-Based Meta-Barcoding Workflow for Parasitic Microbiodiversity Assessment in the Wild Fauna of French Guiana

Adria MATOUTE, Simone MAESTRI, Mona SAOUT, Laure LAGHOE, Stephane SIMON, Helene BLANQUART, Miguel Angel Hernandez Martinez, Magalie PIERRE DEMAR

Subject: Biology And Life Sciences, Other Keywords: Apicomplexa; Amazon; NGS sequencing; Meta-barcoding; Wild mammals

Online: 12 February 2024 (10:24:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1687.v1

Antimicrobial Evaluation of Two Polycyclic Polyprenylated Acylphloroglucinol Compounds: PPAP23 and PPAP53

Aparna Viswanathan Ammanath, Miki Matsuo, Huanhuan Wang, Frank Kraus, Anton Bleisch, Philipp Peslalz, Majd Mohammad, Anne Grießhammer, Moushumi Purkayastha, Andreas Vorbach, Boris Macek, Heike Brötz-Oesterhelt, Lisa Maier, Dorothee Kretschmer, Andreas Peschel, Tao Jin, Bernd Plietker, Friedrich Götz

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: albumin; antimicrobial activity; larvae; mouse septic arthroses; PPAP; gastrointestinal microbes

Online: 24 June 2024 (12:06:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1528.v1

Assessing Nitrogen Fertilization in Processing Pepper: Critical Nitrogen Curve, and Crop Yield Response

Jose Maria Vadillo, Carlos Campillo, Valme Gonzalez, Henar Prieto

Subject: Biology And Life Sciences, Horticulture Keywords: horticulture; open field; vegetative development; fruit production

Online: 20 September 2024 (03:13:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2401.v1

Staphylococcus aureus Stress Response to Bicarbonate Depletion

Elisa Liberini, Sook-Ha Fan, Arnold S. Bayer, Christian Beck, Jacob Biboy, Patrice François, Joe Gray, Katharina Hipp, Iris Koch, Andreas Peschel, Brigitte Sailer, Daniela Vollmer, Waldemar Vollmer, Friedrich Götz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus; bicarbonate transporter; MpsABC; cell wall; peptidoglycan; transcriptome

Online: 30 July 2024 (11:03:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0570.v1

Mir-21 Regulates Growth and Migration of Cervical Cancer Cells by RECK Signaling Pathway

Seidy Y. Aguilar-Martínez, Gabriela E. Campos-Viguri, Selma E. Medina-García, Ricardo J. García-Flores, Jessica Deas, Claudia Gómez-Cerón, Abraham Pedroza-Torres, Elizabeth Bautista-Rodríguez, Gloria Fernández-Tilapa, Mauricio Rodríguez-Dorantes, Carlos Pérez-Plasencia, Oscar Peralta-Zaragoza

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cervical cancer; microRNAs; miR-21; RECK; siRNAs

Online: 9 February 2024 (11:20:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0213.v1

Quasi Cubic Trigonometric Curve and Surface

Guicang Zhang, Kai Wang

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Quasi Extended Chebyshev space; optimal normalized totally positive basis; high-order continuity; shape preserving; shape features

Online: 18 October 2019 (11:33:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1614.v1

Molecular Circuits of Immune Sensing and Response to Oncolytic Virotherapy

Darshak K Bhatt, Toos Daemen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: molecular pathways; oncolytic virus; pattern recognition receptors; transcription factors

Online: 26 March 2024 (16:57:15 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.1157.v1

COVID-19 Therapeutics Use by Social Deprivation in England, July 2020–April 2023

Angela Falola, Hanna Squire, Sabine Bou-Antoun, Alessandra Løchen, Colin S. Brown, Alicia Demirjian

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: antivirals; community; COVID-19; deprivation; hospital; therapeutics

Online: 20 March 2024 (12:31:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0090.v1

Clustering and Curve Fitting by Line Segments

Hrishikesh D. Vinod, Fred Viole

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: clustering; curve fitting; nonparametric regression; smoothing data; polynomial approximation

Online: 10 January 2018 (09:48:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0619.v3

Predicting Wealth using Intelligent Quotient, Emotional Awareness, and Culture

Azad Kabir, Raeed Kabir

Subject: Business, Economics And Management, Finance Keywords: Wealth curve; Intelligence quotient (IQ); Emotional Intelligence (EI); Emotional Awareness (EA)

Online: 23 April 2023 (06:05:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0269.v1

Wind Turbine Power Curve Upgrades

Davide Astolfi, Francesco Castellani, Ludovico Terzi

Subject: Engineering, Mechanical Engineering Keywords: wind energy; wind turbines; SCADA; retrofitting; performance evaluation

Online: 20 April 2018 (14:11:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1524.v1

Global Dynamics of Environmental Kuznets Curve: A Cross-Correlation Analysis of Income and CO2 Emissions

Dora Almeida, Luísa Carvalho, Paulo Ferreira, Andreia Dionísio, Inzamam Ul Haq

Subject: Business, Economics And Management, Economics Keywords: Environmental Kuznets curve; CO2 emissions; Economic growth; Cross-correlation analysis; Income levels; Sustainable development

Online: 19 July 2024 (06:35:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0852.v1

MSProfileR: An Open-Source Software for Quality Control of MALDI-TOF Spectra

Refka Ben Hamouda, Bertrand Estellon, Khalil Himet, Aimen Cherif, Hugo Marthinet, Jean-Marie Loreau, Gaetan Texier, Samuel Granjeaud, Lionel ALMERAS

Subject: Computer Science And Mathematics, Software Keywords: R package; quality control; MALDI-TOF MS; arthropod vectors; Github; rstudio; Shiny interface.

Online: 15 February 2024 (12:11:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0955.v5

Decaying Turbulence as a Fractal Curve

Alexander Migdal

Subject: Computer Science And Mathematics, Analysis Keywords: Turbulence; Fractal; Anomalous dissipation; Fixed point; Velocity circulation; Loop Equations

Online: 6 July 2023 (10:17:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0844.v1

Typhoid Fever, Malaria and their Co-infection: A Review

Emmanuel Ndezure, Kweku Gyasi, Maame Ayaah, Bernard Mintah, Iddrisu Ibrahim, Kwadwo Boampong, Joseph Ayariga

Subject: Biology And Life Sciences, Life Sciences Keywords: Malaria; Typhoid; Fever; Plasmodium; Salmonella; circumsporozoite

Online: 13 May 2024 (12:11:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0082.v1

Analysis of Inflection and Singular Points on Parametric Curve with a Shape Factor

Zhi Liu, Chen Li, Jieqing Tan, Xiaoyan Chen

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: shape factor; singular points; inflection points; local convexity; global convexity

Online: 23 September 2016 (08:04:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1357.v1

Cryptosporidium spp. Infection in Adult Kidney Transplant Patients

Danuta Kosik-Bogacka, Natalia Łanocha-Arendarczyk, Krzysztof Korzeniewski, Joanna Kabat-Koperska, Paweł Ziętek, Małgorzata Marchelek-Myśliwiec

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Cryptosporidium spp.; kidney transplantation; kidney transplantation

Online: 19 June 2024 (14:23:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2237.v1

Potent Anti-HIV-1 Activity of Sacran, a Megamolecular Polysaccharide from Cyanobacterium Aphanothece sacrum, as a Microbicide Candidate

Kouki Matsuda, Ryusho Kariya, Kenji Maeda, Seiji Okada

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: sacran; HIV-1; microbicide

Online: 30 July 2024 (08:57:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0144.v1

Statistical Study on Crash Frequency Model Using GNB Models of Freeway Sharp Horizontal Curve Based on Interactive Influence of 3 Explanatory Variables

Yanjie Zeng, Xiaofei Wang, Lineng Liu, Xinwei Li, Caifeng Jiang

Subject: Engineering, Civil Engineering Keywords: freeway; crash prediction model (CPM); sharp horizontal curve segment (SHCS); interactive influence among three explanatory variables; generalized negative binomial (GNB)

Online: 15 August 2016 (09:47:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2546.v1

Dynamics of Mammarenavirus Wenzhouense Acute Infection in the Rodent Rattus norvegicus

ShanShan Du, XueFei Deng, Xiaoxia Huang, TieZhu Liu, Aqian Li, Qin Wang, TingTing Tian, Chuan Li, ZhangQi Zheng, QiHan Lin, ZhuoWei Li, Shiwen Wang, Jiandong Li

Subject: Public Health And Healthcare, Other Keywords: Wenzhou virus; acute infection; virus shedding, transmission; rodents; arenavirus

Online: 31 July 2024 (15:21:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1272.v1

Therapeutic Vaccination in Chronic Hepatitis B: A Systematic Assessment by the HeberNasvac Therapeutic Vaccine Team

Julio Cesar Aguilar, Sheikh Mohammad Fazle Akbar, Mamun Al-Mahtab, Carlos Alberto Guzman, Guillermo Fernandez, Jorge Aguiar, Marie-Louise Michel, Maryline Bourgine, Maria Acelia Marrero, Stephanie Trittel, Thomas Ebensen, Peggy Riese, Roger LeGrand, Cecile Herate, Aurelie Mauras, Heiner Wedemeyer, Osamu Yoshida, Yoichi Hiasa, Eduardo Penton, Gerardo Guillen

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chronic hepatitis; therapeutic vaccine; functional cure; antiviral; therapy

Online: 19 August 2024 (12:05:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0900.v1

Human Placental Schistosomiasis – a Review of the Literature

Jacob Gerstenberg, Sasmita Mishra, Martha Holtfreter, Joachim Richter, Saskia Dede Davi, Dearie G. Okwu, Michael Ramharter, Johannes Mischlinger, Benjamin T. Schleenvoigt, For TropNet

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Schistosomiasis; Placenta; Adverse Birth Outcomes; Pregnancy; Praziquantel

Online: 15 April 2024 (05:32:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1251.v1

Improved Curve–Flattening for Flexible Space Robotics

Wenxin Li, Timothy Sands

Subject: Engineering, Aerospace Engineering Keywords: robotics; flexible; control; structural filter; space robotics

Online: 30 April 2023 (03:39:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0435.v1

Flattening the Curve of Flexible Space Robotics

Timothy Sands

Subject: Engineering, Control And Systems Engineering Keywords: robotics; monitoring; repair; replace; infrastructure; space robotics; flexible; structural-controls interaction; trajectory shaping

Online: 28 January 2022 (12:12:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0176.v1

Bézier Curve Modeling for Neutrosophic Data Problem

Ferhat Taş, Selçuk Topal

Subject: Computer Science And Mathematics, Mathematics Keywords: neutrosophic sets; neutrosophic logic; bézier curve

Online: 27 April 2017 (02:54:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1277.v1

Sedentary Life Is an Invisible Trap: Molecular, Cellular, and Systemic Reasons to Leave It Behind

Daniel Guerreiro Diniz, João Bento-Torres, Victor Oliveira Da Costa, Josilayne Patrícia Ramos Carvalho, Alessandra Mendonça Tomás, Thaís Cristina Galdino de Oliveira, Fernanda Cabral Soares, Liliane Dias e Dias de Macedo, Naina Yuki Vieira Jardim, Natáli Valim Oliver Bento-Torres, Daniel C. Anthony, Dora Brites, Cristovam Wanderley Picanço-Diniz

Subject: Biology And Life Sciences, Aging Keywords: Age-related cognitive decline; epigenetics; immunosenescence; neurodegeneration; neuron-glia crosstalk; neuroinflammation and oxidative stress; physical exercise; protein aggregation; non-pharmacological and therapeutic interventions; synaptic dysfunction

Online: 20 August 2024 (05:12:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0806.v1

The Impact of Forest Quality on Carbon Emission: A Study of China based on Environmental Kuznets Curve

Yuwen Zhang, Xiaolan Wu, Shengyuan Wang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Forest quality; Environmental Kuznets Curve; Symbiotic System; Emission Reduction Pathway

Online: 10 September 2024 (11:13:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0497.v1

Evaluation of Mis-Selection of Boundary Vertebrae and Its Effect on Measuring Cobb Angle and Curve Length in Adolescent Idiopathic Scoliosis

José Hurtado-Avilés, Vicente J. León-Muñoz, Fernando Santonja-Medina, Paolo Raimondi, Francisco Martínez-Martínez

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: adolescent idiopathic scoliosis; Cobb angle; measurement errors; radiographic Assessment; spine curvature

Online: 7 June 2024 (15:16:27 CEST)

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The Cobb angle is critical in assessing adolescent idiopathic scoliosis (AIS) patients. This study aimed to evaluate the error in selecting the cranial and caudal limit vertebrae on AIS digital X-rays of experienced and novice observers and its correlation with the error in measuring the Cobb angle and determining the length of the scoliotic curves. Using the TraumaMeter v.873 software, eight raters (four experienced and four novices) independently evaluated 68 scoliotic curves on 42 AIS X-rays across three sessions one month apart according to Hopkins’ criteria of absolute reliability. Two spine specialist experts using the Cobb method established the gold standard measurements. The percentage of error in the selection of the cranial vertebrae (the most-tilted vertebra above the apex) is higher than in the caudal vertebrae (the most-tilted vertebrae below the apex) (44.7%, CI95% 41.05-48.3 compared to 35%, CI95% 29.7-40.4). The error in the choice of the most tilted vertebrae, in number of vertebrae per scoliotic curve, was MBE (mean bias error) =0.45, CI95% 0.38-0.52 in the cranial and MBE=0.35, CI% 0.69-0.91 in the caudal. The percentage of errors in the choice of boundary vertebrae is lower for the experienced than for the novices, both in cranial and caudal. The experienced chose at least one boundary vertebrae incorrectly in 52% of the meas-urements and the novices in 65.1%. The error in the Cobb angle did not depend on the number of boundary vertebrae chosen incorrectly (r=0.198, p=0.111). Of the 50% of Cobb angle measurements closest to the actual value, 55.4% (454) were obtained by incorrectly selecting at least one boundary vertebra. There was a positive correlation (r=0.673, p=0.000) between the error in selecting the boundary vertebrae and the error in determining the length of the scoliotic curves. The error in quantifying the length of scoliotic curves was MBE=0.43, CI95% 0.35-0.51 vertebrae per curve. We can conclude that errors in selecting boundary vertebrae are common among experienced and novice observers, with a greater frequency of error in the cranial vertebrae. There is no correlation between the error in selecting the boundary vertebrae and the error in measuring the Cobb angle. Contrary to the consensus, the accuracy of determining the length of the scoliotic curve is limited by the Cobb method’s reliance on the correct selection of boundary vertebrae. Inappropriate choice of boundary vertebrae leads to an estimated error in determining the length of the scoliotic curves of 0.805 vertebrae for each boundary vertebra chosen incorrectly.

Preprint ARTICLE | doi:10.20944/preprints202407.0464.v1

Evaluation of Psychosomatic, Respiratory, and Neurocognitive Health in COVID-19 Survivors 12 Months after ICU Discharge

Nicolas Germann, Daria Amozova, Kristina Göhl-Freyn, Tim Fischer, Manuel Frischknecht, Gian-Reto Kleger, Urs Pietsch, Miodrag Filipovic, Martin H. Brutsche, Thomas Frauenfelder, Christian R. Kahlert, Dagmar A. Schmid, Werner C. Albrich

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; Intensive Unit Care; ICU; Predictive Model; Psychosomatic Health

Online: 5 July 2024 (00:23:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0719.v1

Blood Stream Infections due to Carbapenem-Resistant Gram-Negative Bacilli, Producing Klebsiella pneumoniae Carbapenemase or New Delhi Metallo-β-Lactamase: A Single-Center, Retrospective, Comparative Study in a High-Prevalence Area

Eirini A Apostolidi, Dimitris Basoulis, Sofia Zerva, Amalia Karapanou, Angeliki Pantazatou, Ioannis Deliolanis, Antonios Markogiannakis, Nikolaos V Sipsas, Maria N Gamaletsou

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Blood stream infections; carbapenem-resistant gram-negative bacilli,; Klebsiella pneumoniae carbapenemase; New-Delhi metallo-β-lactamase

Online: 11 June 2024 (15:32:58 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202405.1184.v1

Open Surgical Conversion of Popliteal Endograft Infection: Case Reports And Literature Review

Marta Ascione, Ada Dajci, Rocco Cangiano, Antonio Marzano, Andrea Molinari, Francesca Miceli, Alessia Di Girolamo, Luca Di Marzo, Wassim Mansour

Subject: Medicine And Pharmacology, Surgery Keywords: popliteal aneurysm; endograft infection; popliteal endograft infection; open surgical conversion

Online: 17 May 2024 (13:22:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0051.v1

Search for QPOs in the Light Curve of the Blazar OJ287: Preliminary Results from 2015/16 Observing Campaign

S. Zola, M. Valtonen, G. Bhatta, A. Goyal, B. Debski, A. Baran, J. Krzesinski, M. Siwak, S. Ciprini, A. Gopakumar, H. Jermak, K. Nilsson, D. Reichart, K. Matsumoto, K. Sadakane, K. Gazeas, M. Kidger, V. Piirola, F. Alicavus, K.S. Baliyan, A. Berdyugin, D. Boyd, M. Campas Torrent, F. Campos, J. Carrillo Gomez, D.B. Caton, V. Chavushyan, J. Dalessio, D. Dimitrov, M. Drozdz, A. Erdem, A. Escartin Perez, V. Fallah Ramazani, A.V. Filippenko, F. Garcia, F. Gomez Pinilla, M. Gopinathan, J.B. Haislip, J. Harmanen, G. Hurst, K.M. Ivarsen, M. Jelinek, A. Joshi, M. Kagitani, N. Kaur, N. Karaman, W.C. Keel, A.P. LaCluyze, B.C. Lee, E. Lindfors, J. Lozano De Haro, J.P. Moore, R. Naves Nogues, A.W. Neely, R.H. Nelson, W. Ogloza, S. Okano, J.C. Pandey, M. Perri, P. Pihajoki, G. Poyner, J. Provencal, T. Pursimo, A. Raj, R. Reinthal, S. Sadegi, T. Sakanoi, J.-L. Salto Gonzales, T. Schweyer, F.C. Soldan Alfaro, E. Sonbas, I. Steele, J.T. Stocke, J. Strobl, L.O. Takalo, T. Tomov, L. Tremosa Espasa, J.R. Valdes, J. Valero Perez, F. Verrecchia, J.R. Webb, M. Yoneda, M. Zejmo, W. Zheng, J. Telting, J. Saario, T. Reynolds, A. Kvammen, E. Gafton, R. Karjalainen, P. Blay

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies: active; BL Lacertae objects: individual (OJ 287); super massive black holes

Online: 18 July 2016 (10:46:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0110.v1

COVID-19 Follows a Flattened Growth Curve Subsequent to Prolonged Intervention in A Population; Its Implication on Rate Of Doubling Time & Plausible Suppression of SARS-CoV-2 Infection

prabir chakravarty

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; intervention; growth curve; survival; doubling time; correlation

Online: 7 May 2020 (08:24:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1936.v1

Mononuclear Phagocytes, Cellular Immunity and Nobel Prizes: A Historic Perspective

Siamon Gordon, Annabell Roberti, Stefan Hugo Ernst Kaufmann

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Mononuclear Phagocyte System; Immunity; Macrophages; Dendritic Cells; Multinucleated Giant Cells; Nobel Prizes; Phagocytosis; Plasma Membrane Receptors; Homeostasis; History

Online: 24 July 2024 (13:05:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0370.v1

Cardiovascular Aging in HIV Infection: Analysis of Involved Genes

Fabiola Boccuto, Salvatore De Rosa, Pierangelo Veltri, Daniele Torella, Pietro Hiram Guzzi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: HIV; aging; cardiovascular desease

Online: 6 June 2024 (11:34:56 CEST)

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Working Paper ARTICLE

Flattening COVID-19 Curve in Egypt: An Epidemiological Modelling

Ali Hasab

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; Egypt; Epidemic SIR Model; Pandemic; Flattening the curve

Online: 14 May 2020 (15:12:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0326.v1

Curve Path Detection in Autonomous Vehicle using Deep Learning

Balasriram Kodi, Manimozhi M

Subject: Engineering, Automotive Engineering Keywords: autonomous vehicles, lane detection, curve path detection, convolutional neural networks, deep learning

Online: 24 May 2018 (04:56:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0061.v1

Curve Number Applications for Restoration the Zarqa River Basin

Maisa'a W. Shammout, Muhammad Shatanawi, Jim Nelson

Subject: Environmental And Earth Sciences, Environmental Science Keywords: water scarcity; watershed restoration; land use distribution; soil type; curve number; Zarqa River’s flow simulation; end-users

Online: 8 January 2018 (09:59:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0885.v1

TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary Ciliary Dyskinesia

Gioia Piatti, Giorgia Girotto, Maria Pina Concas, Leonardo Braga, Umberto Ambrosetti, Mirko Aldè

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: bitter taste receptors; TAS2R38; Primary Ciliary Dyskinesia; COVID-19; SARS-CoV-2

Online: 13 June 2024 (05:37:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1319.v1

Dysnatremia as a Mortality Marker in Intensive Care Patients with SARS-CoV-2 Infection

Guler Eraslan Doganay, Melek Doganci, Gulsah Yurtseven, Azra Ozanbarci, Abdullah Kahraman, Ozgur Cirik, Fatma Ozturk Yalcin, Seray Hazer, Kerem Ensarioglu

Subject: Medicine And Pharmacology, Other Keywords: COVID-19; Dysnatremia; Hypernatremia; Hyponatremia; Mortality; SARS-CoV-2.

Online: 20 May 2024 (20:15:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0380.v1

Research Hotspots and Trend Analysis of Community Public Health Based on CiteSpace and VOSviewer

Pingping Wang, Chenhui Deng, Jin Yao, Yaqiong Li, Xiaorong Huang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: community public health; Bibliometrics; Visualization; Development trend; CiteSpace; VOSviewer

Online: 4 July 2024 (14:24:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1170.v1

Effects of Salmonella Typhimurium Infection on Intestinal Flora and Arachidonic Acid Metabolism in Wenchang Chickens

Shenghong Chen, Yaochen Xie, Dingqian Guo, Tiansen Li, Zhen Tan, Xuhua Ran, Xiaobo Wen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Salmonella Typhimurium; gut microbiota; lipid oxidation; arachidonic acid; Wenchang chicken

Online: 17 April 2024 (14:51:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1320.v1

Role of Vaccination on the Co-Infection Model with COVID-19 Associated with Diabetes

Md. Abdul Hye, Md. Haider Ali Biswas, Mohammed Forhad Uddin

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; Diabetes; Comorbidity; Co-infection; Vaccination; Numerical Simulation.

Online: 19 June 2024 (07:27:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2378.v1

Nurse-Driven Quality Improvement Interventions Reduced the Incidence of Central-Line-Associated Bloodstream Infection and Catheter-Related Bloodstream Infection to Close to Zero, a Turning Point in One Pediatric Oncologic Facility

Federico Turoldo, Antonella Longo, Mariavittoria Sala, Denis Valentini, Nicole De Vita, Sara Toniutti, Loredana Zuppel, Natalia Maximova

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: central venous catheter; pediatric; oncological; central-line– associated bloodstream infections; catheter-related bloodstream infections

Online: 30 July 2024 (07:34:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0773.v1

A New Definition of Dual Spline Curves for Curve Modeling and Geometry Defeaturing

Baotao Chi, Shengmin Bai, Qianjian Guo, Yaoming Zhang, Wei Yuan, Can Li

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: Dual spline curves; Adaptive curve refinement; Curve modeling; Geometry defeaturing

Online: 12 July 2023 (05:50:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0487.v1

Modelling Buildings in CityGML LOD1: Building Parts, Terrain Intersection Curve and Address Features

Evgeny Shirinyan, Dessislava Petrova-Antonova

Subject: Engineering, Architecture, Building And Construction Keywords: 3D City Model; CityGML 2.0; Spatial Data Integration

Online: 30 December 2021 (12:51:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0767.v1

Isometric Force-Time Curve Assessment: Accuracy, Precision and Repeatability of a Mobile Application and Portable and Lightweight Device—The DINABANG^®

Dario Santos, Alfredo Bravo-Sánchez, Leonardo Alexandre Peyré-Tartaruga, Franco Simini, Rodrigo Zacca

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: exercise; health; physical fitness; rehabilitation; physical therapy; strength assessment; exercise physiology; sports biomechanics; digital technology

Online: 12 August 2024 (09:58:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0899.v1

Identification and Expression Analysis of Long Noncoding RNAs in Response to Infection with VHSV in Rainbow Trout

Mahmoud Tavakoli alamouti, Ghodrat Rahimi Mianji, Ardeshir Nejati Javaremi, Ayoub Farhadi, Elham Younesi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: lncRNAs; Oncorhynchus mykiss; VHSV; differential expression; high-throughput sequencing

Online: 14 May 2024 (11:37:49 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202210.0466.v1

R-Curve Behavior of Polyhedral Oligomeric Silsesquioxane (POSS)–Epoxy Nanocomposites

Kunal Mishra, Raman Singh

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Polymer matrix composites; POSS; Fracture mechanics; J-integral; Stress intensity factor; Scanning electron microscopy

Online: 31 October 2022 (06:19:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0544.v1

Co-ultraPEALut in Subjective Cognitive Impairment Following SARS-CoV-2 Infection: An Exploratory Retrospective Study

Valentina Cenacchi, Giovanni Furlanis, Alina Menichelli, Alberta Lunardelli, Valentina Pesavento, Paolo Manganotti

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Long-COVID; neuro-long-COVID; SARS-CoV-2; Cognitive impairment; Co-ultraPEALut

Online: 9 February 2024 (10:52:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0161.v1

Bacillus coagulans LMG S-24828 Impairs Candida Virulence and Protects Vaginal Epithelial Cells against Candida Infection In Vitro

Luca Spaggiari, Andrea Ardizzoni, Natalia Pedretti, Ramona Iseppi, Carla Sabia, Rosario Russo, Samyr Kenno, Francesco De Seta, Eva Pericolini

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Bacillus coagulans; Probiotics; Candida; Vaginal epithelial cells

Online: 2 August 2024 (10:47:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0822.v1

Coxsackievirus A7 and Enterovirus A71 Significally Reduce SARS-CoV-2 Infection in Cell and Animal Models

Victor A. Svyatchenko, Stanislav S. Legostaev, Roman Y Lutkovskiy, Elena V. Protopopova, Eugenia P. Ponomareva, Vladimir V. Omigov, Oleg S. Taranov, Vladimir A. Ternovoi, Alexander P. Agafonov, Valery B. Loktev

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; coxsackievirus A7; enterovirus A71; co-infection; Syrian hamster

Online: 14 March 2024 (09:33:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1374.v1

Acarological Risk of Infection With Borrelia burgdorferi, the Lyme Disease Agent, in Staten Island, New York City

Liyang Zhou, Leonid Tsynman, Kamesan Kanapathipillai, Zahir Shah, Waheed I Bajwa

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Lyme disease; Ixodes scapularis; urban green spaces; public health risk

Online: 25 March 2024 (07:31:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1747.v1

Predicting Treatment Outcomes in Patients with Drug-resistant Tuberculosis and HIV Co-infection Using a Supervised Machine Learning Algorithm

Mojisola Clara Hosu, Lindiwe Modest Faye, and Teke Apalata

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: DR-TB; DR-TB/HIV coinfection; treatment outcomes; machine learning; supervised learning algorithm

Online: 23 September 2024 (13:13:06 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202402.1691.v1

Central Line-Associated Bloodstream Infection Due to Elizabethkingia anophelis: Case Report and Literature Review on Pediatric Infections

Sophia Maraki, Nikolaos Katzilakis, Ioannis Neonakis, Dimitra Stafylaki, Viktoria Eirini Mavromanolaki, Ioannis Kyriakidis, Iordanis Pelagiadis, Eftychia Stiakaki

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Elizabethkingia anophelis; pediatric infections; neonate; identification; antimicrobial susceptibility

Online: 29 February 2024 (10:38:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0613.v1

Measurement of Continuous Cooling Transformation Curve and High Temperature Mechanical Properties for 12Mn Steel

Sheng tao Qiu, Jun Wei

Subject: Engineering, Automotive Engineering Keywords: 12Mn steel; round billet; thermal mechanical simulation; CCT curve; diatometer method; JmatPro; tensile strength; the reduction of area; stress-strain curve; Thermal-cal software

Online: 25 March 2021 (11:44:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1211.v1

Genetic Characteristics of Anelloviruses Detected in Individual Viromes of Children with Acute Respiratory Infection Using the Metagenomic Approach

Alina R. Nokhova, Nikita A. Dubovitskiy, Anastasiya A. Derko, Anna A. Khozyainova, Olga G. Kurskaya, Alexander M. Shestopalov, Kirill A. Sharshov

Subject: Biology And Life Sciences, Virology Keywords: viral metagenomics; respiratory virome; torque teno virus; torque teno mini virus; torque teno midi virus; anelloviruses; human anellovirus; Anelloviridae; anellome

Online: 18 April 2024 (07:51:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1668.v2

Human Papillomavirus Requires COPI Coat Complex for a Successful Infection

Edrees Rahmatzada, Om Basukala, Lawrence Banks

Subject: Biology And Life Sciences, Virology Keywords: HPV; virus entry; COPI

Online: 23 April 2024 (11:52:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0618.v1

Enhancing Privacy in the Internet of Vehicles via Hyperelliptic Curve Cryptography

George Routis, Panagiotis Dagas, Ioanna Roussaki

Subject: Computer Science And Mathematics, Security Systems Keywords: Internet of Things (IoT); Internet of Vehicles (IoV); Vehicular Ad-hoc Networks (VANETs); vehicle privacy; digital certificates; digital signatures; ECC; HECC; energy consumption; message size; Arduino; Zigbee

Online: 8 January 2024 (10:52:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0609.v1

To Bend the Curve of Terrestrial Biodiversity, Place Agency Centre Stage

Claude Garcia, Sini Savilaakso, Marieke Sassen, Natasha Stoudmann, René W. Verburg, Fabien Quétier, Miguel B. Araújo, Jean-François Bastin, Laurence Boutinot, Hélène Dessard, Anne Dray, Philip Fernbach, Scott Francisco, Jaboury Ghazoul, Laurène Feintrenie, Babak Naimi, Johan Oszwald, Stephan A. Pietsch, Brian E. Robinson, Plinio Sist, Steven A. Sloman, Terry Sunderland, Cédric Vermeulen, Lucienne Wilmé, Sarah J. Wilson, Patrick O. Waeber

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: agency; transition; cognition; land-use change; games; democracy

Online: 29 October 2020 (11:24:42 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202004.0353.v1

Can Innate Immunity Flatten the Curve? Covid-19 – A Case Study

Sangam Banerjee

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; innate immunity

Online: 19 April 2020 (16:54:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0900.v1

Immuno-Haematologic Aspects of Dengue Infection: Biologic Insights and Clinical Implications

Cherie Tan, Clarice Shi Hui Choong, Muhammad Bilal Abid, Matthew W Weber, Eng Soo Yap, Suranjith L Seneviratne, Visula Abeysuriya, Sanjay de Mel

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Dengue; Immunohematology; Thrombocytopaenia; Immune dysregulation; Haemostatis

Online: 14 May 2024 (08:27:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1094.v1

Development and Evaluation of an In-House Real-Time Rt-Pcr Targeting nsp10 Gene for SARS-CoV-2 Detection

Cyril Chik-Yan Yip, Jane Hau-Ching Poon, Kit-Hang Leung, Wan-Mui Chan, Jonathan Daniel Ip, Allen Wing-Ho Chu, Vincent Chi-Chung Cheng, Kwok-Yung Yuen, Kelvin Kai-Wang To

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; nsp10; real-time RT-PCR; diagnostic

Online: 20 February 2024 (06:07:31 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202405.1446.v1

Flagellin Inhibits HIV Infection of Macrophages through Modulation of Viral Entry Receptors and CC Chemokines

Lina Zhou, Xu Wang, Shazheb Khan, Wen-Zhe Ho

Subject: Biology And Life Sciences, Virology Keywords: flagellin, TLR-5, macrophage, HIV, and CC chemokine

Online: 22 May 2024 (12:57:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1706.v1

First Insight into the Incidence of Coxiella burnetii Infection among Veterinary Medicine Students from Bulgaria

Petia Genova-Kalou, Yordan Hodzhev, Ilia Tsachev, Roman Popovich, Stefan Panaiotov, Veselin Dobrinov, Stefka Krumova, Betina Boneva-Marutsova, Borislava Chakarova, Keytlin Todorova, Konstantin Simeonov, Magdalena Baymakova, Pierre-Edouard Fournier

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Bulgaria; Coxiella burnetii; Q fever; students; veterinary medicine

Online: 24 June 2024 (14:58:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1442.v1

Revalidation of DNA Fragmentation Analyses for Human Sperm—Measurement Principles, Comparative Standards, Calibration Curve, Required Sensitivity, and Eligibility Criteria for Test Sperm—A Step-by-Step Approach to Cohort Studies with Multivariable Analyses

Satoru Kaneko, Yuki Okada

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: DNA fragmentation; single-cell pulsed-field gel electrophoresis; human sperm; sperm chromatin structure assay; sperm chromatin dispersion test; comet assay; quantitative analysis

Online: 23 May 2024 (08:19:18 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202407.0769.v1

Long-Term Oritavancin Therapy for Shoulder Prosthetic Joint Infection: A Case Guided by Therapeutic Drug Monitoring (TDM)

Antonio Riccardo Buonomo, Letizia Cattaneo, Giulio Viceconte, Ferdinando Calabria, Gaia Di Troia, Antonio Di Fusco, Jacopo Mula, Andrea Cozzolino, Luigi Ametrano, Antonio D'Avolio, Ivan Gentile

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Oritavancin; prosthetic joint infections; PJI; therapeutic drug monitoring; TDM; MR; suppressive therapy; outpatient

Online: 10 July 2024 (11:59:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0578.v1

Synergistic Effect of Postbiotic Yeast ABB C22® on Gut Inflammation, Barrier Function and Protection from Rotavirus Infection

Lydia Carrera Marcolin, Jordi Cuñé Castellana, Laia Martí Melero, Carlos de Lecea, Maria Tintoré Gazulla

Subject: Biology And Life Sciences, Other Keywords: diarrhoea; postbiotic; yeast; inflammation; gut protection; Rotavirus

Online: 8 April 2024 (15:10:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0516.v1

Frequency Response Characteristic (FRC) Curve and Fast Frequency Response Assessment in High Renewable Power Systems

Shutang You

Subject: Engineering, Energy And Fuel Technology Keywords: Frequency response characteristic (FRC) curve; frequency response; renewable generation; governor

Online: 26 October 2020 (11:40:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1334.v1

The Long-Term Effect of COVID-19 Infection on Body Composition

Ornina Atieh, Jared C. Durieux, Jhony Baissary, Christian Mouchati, Danielle Labbato, Alicia Thomas, Alexander Merheb, Kate Ailstock, Nicholas Funderburg, Grace A. McComsey

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: long-COVID; PASC; Body composition; COVID pandemic

Online: 22 March 2024 (11:18:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.2098.v1

Musculoskeletal Infection: The Great Mimickers on Imaging

Michail E. Klontzas, Evangelia E. Vassalou, Konstantinos Spanakis, Kalliopi Alpantaki, Apostolos H. Karantanas

Subject: Medicine And Pharmacology, Other Keywords: musculoskeletal; infection; mimicker; differential; septic; osteomyelitis; septic arthritis; spondylodisciitis

Online: 29 August 2024 (08:39:07 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202402.0678.v1

Comparative Sensitivity Between Fecal Sedimentation And Fecal Antigen Elisa For Diagnosis Of Fasciola Infection In Cattle

Naim Che-Kamaruddin, Nur Mahiza Md Isa

Subject: Biology And Life Sciences, Parasitology Keywords: coproantigen ELISA; farm; liver fluke; parasite egg count

Online: 12 February 2024 (11:10:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1711.v1

Dendritic Cells, Th17 Cells & Tendinopathy

Shimon V Z Wasker, Julia Beretov, Neal Millar, Patrick Lam, George A C Murrell

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Tendon; Monocyte-derived dendritic cells; Tendinopathy; IL-17

Online: 29 February 2024 (10:11:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.1137.v1

V2G Strategies to Flatten the Daily Load Curve in Seoul, South Korea

Sangbong Choi, Changsoo Kim, Backsub Sung

Subject: Engineering, Electrical And Electronic Engineering Keywords: V2G strategie; daily load curve; charging location; discharging location; time-of-use (TOU); system marginal price (SMP)

Online: 28 April 2023 (07:25:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0157.v1

Identify the Mathematical Models Generated by the Table Curve 3 D Program

Emilian Mosnegutu, Mirela Panainte-Lehadus, Valentin Nedeff, Claudia Tomozei, Narcis Barsan, Dana Chitimus, Marcin Jasinski

Subject: Computer Science And Mathematics, Mathematics Keywords: mathematical models; Table Curve 3D; correlation coefficient

Online: 11 February 2022 (08:35:16 CET)

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Working Paper REVIEW

Bending the Curve of Global Freshwater Biodiversity Loss – An Emergency Recovery Plan

David Tickner, Jeff Opperman, Robin Abell, Mike Acreman, Angela H. Arthington, Stuart E. Bunn, Steven J. Cooke, James Dalton, Will Darwall, Gavin Edwards, Ian Harrison, Kathy Hughes, Tim Jones, David Leclère, Abigail J. Lynch, Philip Leonard, Michael E. McClain, Dean Muruven, Julian D. Olden, Steve Ormerod, Rebecca E. Tharme, Michele Thieme, Klement Tockner, Mark Wright, Lucy Young

Subject: Environmental And Earth Sciences, Ecology Keywords: River restoration; wetlands; freshwater conservation; Sustainable Development Goals; Convention on Biological Diversity

Online: 29 October 2019 (11:13:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1498.v1

Reply to León et al. (2024): Interpretation and Use of In-Field Diagnostics for High Pathogenicity Avian Influenza (HPAI) in Antarctica– A Cautionary Tale

Michelle Wille, Ralph E. T. Vanstreels, Marcela Uhart, Scott Reid, Meagan Dewar, Ashley C Banyard

Subject: Biology And Life Sciences, Virology Keywords: avian influenza; LPAI; HPAI; high pathogenicity avian influenza; panguins; Antarctica

Online: 23 April 2024 (05:30:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1972.v1

Mixed Mosaic Virus Infection and Its Impact on Photosynthetic Gene Expression in Sugarcane Fields in Indonesia

Intan Ria Neliana, Bambang Sugiharto, Wardatus Soleha, Suherman Suherman, Nurmalasari Darsono, Rikno Harmoko, Widhi Dyah Sawitri

Subject: Biology And Life Sciences, Virology Keywords: sugarcane, mosaic virus infection, mixed infections, photosynthetic parameters

Online: 30 April 2024 (08:44:00 CEST)

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Sugarcane mosaic virus (SCMV) and sugarcane streak mosaic virus (SCSMV) are the primary viruses responsible for mosaic diseases in sugarcane. In this study, the mosaic viruses SCMV and SCSMV with the involvement of sorghum mosaic virus (SrMV) were surveyed from eight commercial sugarcane cultivars grown in fields at four locations in East Java, Indonesia. Sugarcane leaves with mosaic symptoms were assessed for disease incidence and severity, and symptomatic leaves were collected for analysis. The incidence and severity of mosaic symptoms were the highest in the PS881 and NX04 cultivars grown in Kediri compared to the other cultivars. RT-PCR analysis showed that SCSMV was present in all sugarcane cultivars and locations. Interestingly, double mixed infections with SCMV were found in PS881, PS882, and Cening, whereas triple mixed infections with SrMV were found in the PS881 cultivar. Phylogenetic analysis grouped SCSMV, SCMV, and SrMV together with isolates from Thailand (KP987832.1), Florida, USA (MT725538.1), and Agentina (EU189037.1). The expression of ascorbate peroxidase gene (Apx) was increased in the virus-infected sugarcane cultivars and prominently elevated in the triple mixed infection of PS881 cultivars. However, the catalase gene (Cat) was slightly upregulated in the mixed infection group. The chlorophyll content was significantly reduced in the leaves of PS58, PS881, PS882, NX04, and HW Merah, in parallel with the expression of the photosystem I gene (PsaA). The expression of photosynthetic genes, such as ribulose-1,5 bisphosphate carboxylase small sub-unit (RbcS), phosphoenolpyruvate carboxylase (Pepc), sucrose-phosphate synthase (Sps1), and PsaA, was significantly reduced and almost depleted in the triple mixed infection of PS881, except for Pepc expression, which remained approximately half of that in the control healthy sugarcane. The decrease in photosynthetic activity was confirmed by the decrease in ribulose-1,5 bisphosphate carboxylase (Rubisco) and PEPC proteins, as detected by immunoblot analysis. The decrease in photosynthetic parameters indicated that the mosaic viral infection substantially reduced the growth and yield of sugarcane.

Preprint REVIEW | doi:10.20944/preprints202403.1092.v3

Exploring the role of HPV - from Sexually Transmitted Infection to Oropharyngeal Carcinoma

Kritika Srinivasan Rajsri, Vaishnavi Rao, Sonaj Vardhman

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Human papillomavirus; Sexually transmitted infection; Oropharyngeal carcinoma; Oral cancer; Head and neck cancers

Online: 27 June 2024 (05:01:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1873.v1

Association of Hyperechoic Fetal Bowel with COVID-19 Infection in Pregnancy: A Prospective Cohort Study

Vincenzo Spina, Pierluigi Palazzetti, Cristina Fabiani, Rocco Rago, Francesco Bisogni, Lorenzo Campanella, Debora Grilli, Michele Carlo Schiavi, Antonio Simone Laganà, Pietro Cignini

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: hyperechoic fetal bowel 1; sars-cov-2 2; anomaly scan 3, transplacental trasmission 4

Online: 25 July 2024 (12:51:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1253.v1

Antiviral Effect of Antimicrobial Peptoids and a Murine Model of Respiratory Coronavirus Infection

Maxim Lebedev, Aaron Benjamin, Sathish Kumar, Natalia Molchanova, Jennifer S. Lin, Kent J. Koster, Julian L. Leibowitz, Annelise E. Barron, Jeffrey D. Cirillo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Peptoid; MHV; SARS-CoV-2; Antimicrobials

Online: 22 February 2024 (09:24:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0223.v3

Metabolic Modeling Elucidates Phenformin and Atpenin A5 as Broad-Spectrum Antiviral Drugs

Alina Renz, Mirjam Hohner, Maximilian Breitenbach, Jonathan Josephs-Spaulding, Johanna Dürrwald, Lena Best, Victoria Dulière, Chloé Mialon, Stefanie M. Bader, Raphaël Jami, Georgios Marinos, Nantia Leonidou, Filipe Cabreiro, Marc Pellegrini, Marcel Doerflinger, Manuel Rosa-Calatrava, Andrés Pizzorno, Andreas Dräger, Michael Schindler, Christoph Kaleta

Subject: Biology And Life Sciences, Virology Keywords: Drug discovery; Systems biology; SARS-CoV-2; Dengue; Influenza A; RSV; cell viability analysis; antivirals; in vitro validation; in vivo validation

Online: 22 March 2024 (16:46:59 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0868.v1

IgA Nephropathy with Hepatitis B Infection: A Rare Case of Infection and Autoimmunity

Simoni Shah, Heer Shah, Anushree Doshi, Vismit Gami, Dev Desai

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: IgA nephropathy; Hepatitis B Infection; Autoimmune; Hematuria

Online: 15 April 2024 (09:05:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints201705.0176.v1

Zinc in Infection and Inflammation

Nour Zahi Gammoh, Lothar Rink

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Zinc; infection; inflammation; homeostasis

Online: 24 May 2017 (08:48:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0125.v1

Intraperitoneal Administration of 17-DMAG as an Effective Treatment Against Leishmania braziliensis Infection in BALB/c Mice: A Preclinical Study

Kercia P. Cruz, Antonio L. O. A. Petersen, Marina F. Amorim, Alan G. S. F. Pinho, Luana C. Palma, Diana A. S. Dantas, Mariana R. G. Silveira, Carine S. A. Silva, Ana Luiza J. Cordeiro, Izabella G. Oliveira, Gabriella B. Pita, Bianca C. A. Souza, Gilberto C. Bonfim, Claudia I. Brodskyn, Deborah B. M. Fraga, Isadora S. Lima, Maria B. R. de Santana, Helena M. P . Teixeira, Juliana P. B. Menezes, Washington L. P. Santos, Patricia S. T. Veras

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Leishmania braziliensis; Cutaneous leishmaniasis; 17-DMAG-HCL; Treatment

Online: 1 July 2024 (15:41:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1770.v1

Screening for Latent Tuberculosis Infection in People Living with HIV: TUBHIVIT Project, a Multicentre Italian Study

Luca Pipitò, Elena Delfina Ricci, Paolo Maggi, Giuseppe Vittorio De Socio, Giovanni Francesco Pellicano, Marcello Trizzino, Raffaella Rubino, Alessandra Lanzi, Lorenzo Crupi, Ilaria Capriglione, Nicola Squillace, Giuseppe Nunnari, Antonio Di Biagio, Paolo Bonfanti, Antonio Cascio

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Tuberculosis; HIV; latent tuberculosis; TB; LTBI

Online: 26 April 2024 (20:02:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2137.v1

Hardware Implementations of Elliptic Curve Cryptography Using Shift-Sub Based Modular Multiplication Algorithms

Yamin Li

Subject: Computer Science And Mathematics, Security Systems Keywords: elliptic curve cryptography; affine, projective, and Jacobian coordinates; modular multiplication; hardware security module; Verilog HDL; FPGA; cost/performance evaluation

Online: 31 August 2023 (09:35:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0192.v1

Evaluation of the Daily Load Curve by Taking V2G of PEVs into Consideration

Sangbong Choi, Chang soo Kim, Back sub Sung

Subject: Engineering, Electrical And Electronic Engineering Keywords: Charging location; Discharging location; Time of Use(TOU); System Marginal Price(SMP)

Online: 10 November 2022 (05:59:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0438.v1

The Laboratory Opossum (Monodelphis domestica) Is a Unique Model for Zika Virus Infection, Transmission, and Immune Response

André Filipe Pastor, Susan M. Mahaney, Juan Garcia Jr., Marisol Morales, Oscar Quintanilla, Marco A. Arriaga, John M. Thomas III, John L. VandeBerg

Subject: Biology And Life Sciences, Virology Keywords: Zika virus antibodies; Zika virus ELISA; Zika virus PCR; marsupial immunology; flavivirus

Online: 7 August 2024 (03:14:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0886.v1

A New Test Method of “Nuclear Magnetic Resonance + High-Speed Centrifugation” for Gas-Water Relative Permeability Curve of Low-Permeability and Tight Sandstone

Fenglai Yang, Huaxun Liu, Shusheng Gao, Sijie He, Feifei Fang, Cuili Wang, Liyou Ye, Kun Zhou, Xuejun Yang, Weiguo An

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: Low permeability and tight sandstone; Nuclear magnetic resonance (NMR); High speed centrifugation; Micro pore structure; Gas-water relative permeability curve

Online: 11 July 2024 (08:28:50 CEST)

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Gas-water relative permeability curve is the foundation of gas reservoir dynamic analysis and numerical simulation. It is generally obtained through gas displacing water experiment. Referring to the existing national standards, gas-water relative permeability test is carried out for low-permeability and tight sandstone. The flow is discontinuous and the curve smoothness is poor, which affects the application of gas-water relative permeability curve. Based on the comparative analysis of a large number of mercury injection and NMR experimental results of low-permeability and tight sandstone, a method to characterize the throat radius distribution of low-permeability tight sandstone based on NMR T2 spectrum is explored. Combined with high-speed centrifugal experiment, the calculation formulas of core water saturation, phase relative permeability of gas-water under different centrifugal force are established. A new method of "nuclear magnetic resonance + high-speed centrifugation" for gas-water relative permeability curve test of low-permeability and tight sandstone is formed, and the test is carried out on Sulige low-permeability tight sandstone core. The results show that: (1) The shape of cumulative distribution curve of throat radius by mercury injection method is basically consistent with that of T2 relaxation time by NMR, and there is a good corresponding relationship between them. (2) The centrifugation process is similar to the gas displacing water process. With the decrease of water saturation, water centrifugation in rock core becomes more and more difficult until it become irreducible. (3) The test process of the new method is unified and standard and up to 6 cores can be tested at the same time. The calculation results of water saturation and relative permeability curve are reliable and the integral curve is smooth, which greatly improves the test efficiency of gas-water relative permeability curve in low-permeability and tight sandstone. The new method can be widely used to study the gas-water two-phase seepage law in low-permeability and tight sandstone gas reservoir.

Preprint ARTICLE | doi:10.20944/preprints202404.1115.v1

Low Number of Baselines γδ T Cells Increase the Risk of SARS-CoV-2 Post-Vaccination Infection

Juan Carlos Andreu-Ballester, Lorena Galindo-Regal, Carmen Cuellar, Francisca López-Chuliá, Carlos García-Ballesteros, Leonor Fernández-Muga, Antonio Llombart-Cussac, María Victoria Domínguez-Márquez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; vaccine; antibodies; α β T cells; γ δ T cells

Online: 17 April 2024 (08:00:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2044.v1

The preS-Based Recombinant Vaccine VVX001 Induces Hepatitis B Virus Neutralizing Antibodies in a Low-Responder to HBsAg-Based HBV Vaccines

Inna Tulaeva, Felix Lehmann, Nora Goldmann, Alexandra Dubovets, Daria Trifonova, Mikhail Tulaev, Carolin Cornelius, Milena Weber, Margarete Focke-Tejkl, Alexander Karaulov, Rainer Henning, Ursula Wiedermann-Schmidt, Dieter Glebe, Rudolf Valenta

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: HBV vaccines; preS surface antigen; HBsAg; non-responsiveness

Online: 26 July 2024 (08:07:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0190.v1

Equine Herpesvirus Type 1 ORF76 Encoding US9 as a Neurovirulence Factor in the Mouse Infection Model

Mohamed Nayel, Samy Kasem, Noriko Fukushi, Nagwan El-Habashi, Ahmed Elsify, Akram Salama, Hany Hassan, Tokuma Yanai, Kenji Ohya, Hideto Fukushi

Subject: Biology And Life Sciences, Virology Keywords: EHV-1; neurovirulence; US9; ORF76

Online: 3 September 2024 (09:42:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0633.v1

The Iron Chelator, DIBI, Reduces Bacterial Load and Inflammation in Experimental Lung Infection

Xiyang Zhang, Rhea Nickerson, Lauren Burton, Ashley Stueck, Bruce Holbein, Zhenyu Cheng, Juan Zhou, Christian Lehmann

Subject: Biology And Life Sciences, Life Sciences Keywords: Lung infection; Pseudomonas aeruginosa; Iron chelation; Inflammation

Online: 11 June 2024 (08:39:22 CEST)

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