BBC Russian

Preprint ARTICLE | doi:10.20944/preprints202409.0999.v1

Assessing the Feasibility of Handheld Cameras to Increase Access to Teleretinal Diabetic Retinopathy Screenings in Safety-Net Clinics in Los Angeles

Gabrielle Green, Roxana Flores, Elvia Figueroa, Tony Kuo, Lauren Daskivich

Subject: Public Health And Healthcare, Primary Health Care Keywords: Teleretinal diabetic retinopathy screenings; handheld cameras; safety-net; diabetes; feasibility

Online: 12 September 2024 (16:01:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202212.0183.v1

Sports Cranio-Brain Injury. Diagnostics and Prevention of Complications

Oleg Alexeevich Shevelev, Alexander Smolensky, Marina Petrova, Mikhail Yu Yuriev, Maria Aleksandrovna Zdanova, Elias Mesfin Mengistu, Inna Zelikovna Kostenkova, Darina Menzhurenkova, Sergey Vesnin, Igor Goryanin

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: hypothermia; sportstr; brain injury; rehabilitation; hyperthermia

Online: 9 December 2022 (14:50:39 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201701.0033.v1

Establish and Apply a Safe and Convenient Pseudovirus-Based Assay to Detect Neutralizing Antibodies against Influenza A (H7N9) Virus

Li Zhang, Jing Lu, Jingxing Li, Rong Tang, Haiyan Peng, Fanyue Meng, Yuemei Hu

Subject: Biology And Life Sciences, Virology Keywords: H7N9 avian influenza; pseudovirus; neutralization assay; relative luminescence units (RLU)

Online: 6 January 2017 (10:21:52 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202408.0752.v1

Dietary Exposure to Pesticide and Veterinary Drugs Residues and Their Effects on Human Fertility and Embryo Development: A Global Overview

Ambra Colopi, Eugenia Guida, Silvia Cacciotti, Serena Fuda, Matteo Lampitto, Angelo Onorato, Alice Zucchi, Carmela Rita Balestrieri, Paola Grimaldi, Marco Barchi

Subject: Biology And Life Sciences, Life Sciences Keywords: food contaminants; transgenerational inheritance; organophosphates; glyphosate; antibiotics; active pharmaceutical ingredients

Online: 13 August 2024 (03:18:02 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0180.v1

The Distal Promoter of the B438L Gene of African Swine Fever Virus Is Responsible for the mRNA Transcription of the B438L and the Alternatively Spliced B169L

Hongwei Cao, Hao Deng, Yanjin Wang, Diqiu Liu, Lian-Feng Li, Meilin Li, Dingkun Peng, Jingwen Dai, Jiaqi Li, Hua-Ji Qiu, Su Li

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: African swine fever virus; B438L promoter; transcription initiation; B169L protein

Online: 3 May 2024 (09:46:58 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201608.0030.v2

Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China

Chao Wang, Shuang Li, Tao Li, Shanfa Yu, Junming Dai, Xiaoman Liu, Xiaojun Zhu, Yuqing Ji, Jin Wang

Subject: Social Sciences, Psychology Keywords: occupational stress; job burden-capital model; structural equation model; depression; well-being

Online: 4 August 2016 (12:47:57 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.1104.v1

MR protocol optimization for Hepatobiliary Phase Imaging with Gadoxetic Acid for 1.5T: Comparison Between Breath-Hold T1-weighted and High Resolution Navigated 3D T1-weighted sequences

Eliseo Picchi, Valentina Ferrazzoli, Valeria Liberto, Luca Toti, Raffaella Giocondo, Valerio Da Ros, Noemi Pucci, Silvia Minosse, Francesco Garaci, Francesca Di Giuliano

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Magnetic Resonance; Gadoxetic Acid; High Resolution Navigated 3D; Hepatocarcinoma

Online: 17 June 2024 (08:06:12 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1578.v1

TransPerineal Laser Ablation (TPLA) Treatment of Focal Low-Intermediate Risk Prostate Cancer

Guglielmo Manenti, Tommaso Perretta, Marco Nezzo, Federico Romeo Fraioli, Beatrice Carreri, Paola Elda Gigliotti, Andrea Micillo, Andrea Malizia, Daniele Di Giovanni, Colleen Patricia Ryan, Francesco Giuseppe Garaci

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: mpMRI; prostate cancer; TPLA; FLA; focal laser ablation; transperineal laser ablation

Online: 28 February 2024 (04:48:26 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.2546.v1

Dynamics of Mammarenavirus Wenzhouense Acute Infection in the Rodent Rattus norvegicus

ShanShan Du, XueFei Deng, Xiaoxia Huang, TieZhu Liu, Aqian Li, Qin Wang, TingTing Tian, Chuan Li, ZhangQi Zheng, QiHan Lin, ZhuoWei Li, Shiwen Wang, Jiandong Li

Subject: Public Health And Healthcare, Other Keywords: Wenzhou virus; acute infection; virus shedding, transmission; rodents; arenavirus

Online: 31 July 2024 (15:21:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.1291.v1

Development of Smallpox Antibody Testing and Surveillance Following Smallpox Vaccination in the Republic of Korea

Hwachul Shin, SangEun Lee, Myung-Min Choi, Hwajung Yi, Yoon-Seok Chung

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: smallpox; Vaccinia virus; smallpox vaccine; antibody titer; ELISA; bioterrorism

Online: 20 August 2024 (04:55:15 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1545.v1

Comprehensive Geophysical Exploration Technology for Sedimentary Exhalative Deposits: An Example from the Huaniushan Lead-Zinc-Silver Polymetallic Deposit in Gansu, China

Shunji Wang, Guanwen GU, Ye Wu, Xingguo Niu, Lin Zhu, Zhihe Xu, Haoyuan He, Yingjie Wang, Xinglong Lin, Lai Cao

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Sedimentary exhalative deposit; Huaniushan lead-zinc-silver polymetallic deposit; Gravity, magnetic and electric exploration; Three-dimensional inversion; Three-dimensional geological-geophysical model

Online: 19 September 2024 (14:53:35 CEST)

Show abstract| Download PDF| Share

The Huaniushan lead-zinc-silver deposit is a hydrothermal sedimentary exhalative deposit (SEDEX). The mining area has complex geological conditions. The main tectonic structure in the area is the Huaheitan-Shuangfengshan Fault (F3), which controls the distribution of strata and magmatic rocks. Since the discovery of the Huaniushan Lead-zinc-silver polymetallic deposit, there are diverse understandings of the deposit's genesis and mineralization law, making it challenging to meet the geological interpretation requirements of the Huaniushan Lead-zinc-silver polymetallic deposit. Moreover, a single geophysical exploration method utilizes limited rock physical parameters, making it difficult to effectively characterize underground structures. The integrated exploration of multiple geophysical methods can effectively integrate the geophysical characteristics of different rock physical parameters, reducing the multiplicity and uncertainty of geophysical data inverse interpretation. The comprehensive interpretation of three-dimensional inversion based on various geophysical data, the construction of geological-geophysical models based on geological grounds, the establishment of hidden ore exploration and positioning, and the rapid evaluation of geophysical technology systems are the current development trends in mineral exploration. In light of this, this paper conducts research on the three-dimensional inversion interpretation of the heavy magnetoelectric exploration data of the Huaniushan sedimentary exhalative deposit lead-zinc-silver polymetallic deposit in the mining area and constructs a three-dimensional geological-geophysical model of the study area based on the obtained three-dimensional physical structure of the underground three-dimensional density, magnetization intensity, resistivity, and polarizability structure of the study area, in combination with the information of related geology and drilling holes. It comprehensively interprets the favorable mineralization parts in the study area.

Preprint ARTICLE | doi:10.20944/preprints202408.0600.v1

Characterization of Avian Influenza Viruses Detected in Kenyan Live Bird Markets and Wild Bird Habitats Reveal Genetically Diverse Subtypes and High Proportion of A(H9N2), 2018-2020

Peninah Munyua, Eric Osoro, Joyce Jones, George Njogu, Genyan Yang, Elizabeth Hunsperger, Christine Szablewski, Ruth Njoroge, Doris Marwanga, Harry Oyas, Ben Andagalu, Romona Ndanyi, Nancy Otieno, Vincent Obanda, Carolyne Nasimiyu, Obadiah Njagi, Juliana DaSilva, Yunho Jang, John R Barnes, Gideon Emukule, Clayton Onyango, Charles Davis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Africa; surveillance; poultry diseases; avian influenza; low pathogenic

Online: 8 August 2024 (08:53:37 CEST)

Show abstract| Download PDF| Share

Following the detection of highly pathogenic avian influenza (HPAI) virus in countries bordering Kenya to the west, we conducted surveillance among domestic and wild birds along the shores of Lake Victoria. In addition, between 2018 and 2020, we conducted surveillance among poultry and poultry workers in live bird markets and among wild migratory birds in various lakes that are resting sites during migration to assess introduction and circulation of avian influenza viruses in these populations. We tested 7,464 specimens (oropharyngeal and cloacal swabs) from poultry and 6,531 fresh fecal specimens from wild birds for influenza A viruses by real-time RT-PCR. Influenza was detected in 3.9% (n=292) of specimens collected from poultry and 0.2% (n=10) of fecal specimens from wild birds. On hemagglutinin subtyping, most of the influenza A positives from poultry (274/292, 93.8%) were H9. Of 34 H9 specimens randomly selected for further subtyping, all were H9N2. On phylogenetic analysis, these viruses were genetically similar to other H9 viruses detected in East Africa. Only two of the ten influenza A positive specimens from the wild bird fecal specimens were successfully subtyped; sequencing analysis of one specimen collected in 2018 was identified as low pathogenicity avian influenza H5N2 virus of the Eurasian lineage and the second specimen, collected in 2020, was subtyped as H11. A total of 18 OP/NS swabs from poultry workers with ARI (12%) were collected; none were positive for influenza A virus. We observed significant circulation of H9N2 influenza viruses in poultry in live bird markets in Kenya. During the same period, low pathogenic H5N2 virus was detected in a fecal specimen collected in a site hosting a variety of migratory and resident birds. Although HPAI H5N8 was not detected in this survey, these results highlight the potential for introduction and establishment of highly pathogenic avian influenza viruses in poultry populations and the associated risk of spillover to human populations.

Preprint REVIEW | doi:10.20944/preprints202405.1669.v1

Enhancing Performance And Reducing Injury Risk: Integrating Resistance And Flexibility Training For Hamstring Injury Prevention In Rural-based Soccer Players– A Narrative Review

Nontokozo Myeza, Nolwazi Mdladla, Nduduzo Shandu

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Injury prevention; strength training; range of motion training; soccer; rural areas; sports performance enhancement

Online: 27 May 2024 (09:48:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.1232.v1

Feasibility of Emergency Flood Traffic Road Damage Assessment by Integrating Remote Sensing Images and Social Media Information

Hong Zhu, Jian Meng, Jiaqi Yao, Nan Xu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Multi-source heterogeneity; Flood disaster; Social media information; TextCNN-Attention; Transportation roads; Loss assessment

Online: 19 August 2024 (04:33:27 CEST)

Show abstract| Download PDF| Share

In the context of global climate change, the frequency of sudden natural disasters is increasing. Assessing traffic road damage post-disaster is crucial for emergency decision-making and disaster management. Traditional ground observation methods for evaluating traffic road damage are limited by the timeliness and coverage of data updates. Relying solely on these methods does not adequately support rapid assessment and emergency management during extreme natural disasters. Social media, a major source of big data, can effectively address these limitations by providing more timely and comprehensive disaster information. Motivated by this, we utilized multi-source heterogeneous data to assess the damage to traffic roads under extreme conditions and established a new framework for evaluating traffic roads in cities prone to flood disasters caused by rainstorms. The approach involves several steps: First, extracting the surface area affected by precipitation using a threshold method constrained by confidence intervals derived from microwave remote sensing images; Second, collecting disaster information from the Sina Weibo platform, where social media information is screened and cleaned. A quantification table for road traffic loss assessment was defined, and a social media disaster information classification model combining text convolutional neural networks and attention mechanisms was proposed (TextCNN-Attention Disaster Classification); Finally, matching traffic road information on social media with basic geographic data, visualizing the classification of traffic road disaster risk levels, and completing the assessment of traffic road disaster levels based on multi-source heterogeneous data. Using the "7.20" rainstorm event in Henan Province as an example, this study categorizes the disaster impact on traffic roads into five levels: particularly severe, severe, moderate, mild, and affected, as interpreted from remote sensing images. The evaluation framework for flood disaster traffic roads based on multi-source heterogeneous data provides important data support and methodological support for enhancing disaster management capabilities and systems.

Preprint ARTICLE | doi:10.20944/preprints202403.0440.v1

Partial Substitution of Chemical N with Solid Cow Manure Improved Soil Ecological Indicators and Crop Yield in a Wheat-Rice Rotation System

Jintao Yu, Chun Zhang, Xuan Wang, Hongchuan Li, Yusef Kianpoor Kalkhajeh, Hongxiang Hu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: conventional fertilization; solid cow manure; crop quality; soil nutrients; ecological risk

Online: 7 March 2024 (13:10:19 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.1060.v1

Assessment of Earthquake Damage and Economic Recovery in Hatay Province, Turkey Using Nighttime Light Data

Feng Li, Shunbao Liao, Xiaobo Zhang, Tianxuan Liu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: rapid assessment method; Turkey earthquake damage; economic recovery assessment; Hatay Province; nighttime light; NPP-VIIRS; SDGSAT-1

Online: 12 July 2024 (13:50:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.1019.v1

A Rationally Designed H5 Hemagglutinin Subunit Vaccine Provides Broad-Spectrum Protection against Various H5Nx highly Pathogenic Avian Influenza Viruses in Chickens

Xuxiao Zhang, Xin Li, Fushou Zhang, Xiaoping Cui, Xiaoqin Guo, Zhi Sun, Pengju Guo, Ming Liao, Ning Chen

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: avian influenza virus; H5 subtype; subunit vaccine; broad protection

Online: 12 July 2024 (08:42:33 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0538.v1

Wastewater-Based Epidemiology for SARS-CoV-2 in Northern Italy: A Spatiotemporal Model

Matilde Fondriest, Lorenzo Vaccari, Federico Aldrovandi, Laura De Lellis, Filippo Ferretti, Carmine Fiorentino, Erica Mari, Maria Grazia Mascolo, Laura Minelli, Vincenza Perlangeli, Giuseppe Bortone, Paolo Pandolfi, Annamaria Colacci, Andrea Ranzi

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Wastewater-based epidemiology; SARS-CoV-2; COVID-19; wastewater; biodegradation; sewer network; spatiotemporal model; public health; early-warning system

Online: 8 April 2024 (14:48:16 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202409.1667.v1

Antioxidant Effects of Aromatic Plant Extracts in Neurodegenerative Diseases: A Review

Youyang Zhu, Miao Tian, Yuliang Qin, Ting Zhao, Zhaofu Li, Dongdong Qin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurodegenerative diseases; Oxidative stress; Antioxidants; Aromatic plants extracts

Online: 20 September 2024 (20:20:02 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202407.1450.v1

Stat3 Inhibitors TTI-101 and SH5-07 Suppress Bladder Cancer Cell Survival In 3D Tumor Models

Surya Pratap Singh, Gopal Pathuri, Adam S Asch, Chinthalapally V. Rao, Venkateshwar Madka

Subject: Biology And Life Sciences, Life Sciences Keywords: Bladder cancer; STAT3 inhibitor; Apoptosis; Preclinical; 3D models

Online: 17 July 2024 (14:18:54 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0029.v1

Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review.

Renate Viebahn-Haensler, Olga León Fernández

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: redox bioregulation; mitochondriopathies; low-dose ozone concept; ozone therapy; oxidative stress; antioxidant capacity

Online: 1 May 2024 (07:29:18 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0026.v1

Molecular Prevalence, Genetic Diversity, and Tissue Tropism of Bartonella Species in Small Mammals from Yunnan Province, China

Pei-Yu Han, Fen-Hui Xu, Jia-Wei Tian, Jun-Ying Zhao, Ze Yang, Wei Kong, Bo Wang, Li-Jun Guo, Yun-Zhi Zhang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Bartonella; small mammals; genetic diversity; evolution; tissue tropism

Online: 1 April 2024 (17:07:19 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201701.0034.v1

Game Analysis of Low Carbonization for Urban Logistics Service Systems

Jidong Guo, Shugang Ma

Subject: Business, Economics And Management, Business And Management Keywords: 3PLs; E-business enterprise; low carbonization; game theory; Nash Equilibria

Online: 9 January 2017 (03:29:14 CET)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202409.0501.v1

Prospect on Damage Control in Current ASD Intervention

Qi Zhang, Qiang Li

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism; Immune stress; Brain damage; Damage control

Online: 6 September 2024 (09:40:08 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1367.v1

Characteristics and Injury Patterns in Traumatic Brain Injury Related to E-scooter Use in Riga, Latvia: Multicenter Case Series

Agnis Saulitis, Evelina Kocane, Julija Dolgopolova, Ritvars Kalnins, Kaspars Auslands, Kristaps Rancans, Egils Valeinis, Andrejs Millers

Subject: Public Health And Healthcare, Other Keywords: electric scooter; e-scooter; traffic accident; craniofacial trauma; traumatic brain injury; neurosurgery

Online: 25 February 2024 (23:31:46 CET)

Show abstract| Download PDF| Share

Background and Objectives: In recent years Electronic scooters (E-Scooters) have gained popularity, whether for private use or as a publicly available transportation method. With introduction of these vehicles, reports of E-Scooter related accidents have surged, sparking a public debate and concern. Aim of this study was to analyse epidemiological data, characteristics and severity of traumatic brain injury (TBI) related to E-Scooter accidents. Materials and Methods: This retrospective case series evaluated 28 patients who were admitted to three largest neurosurgery clinics in Riga, Latvia between time period from April to October in two separate years – 2022 and 2023 after an E-Scooter related accident. Data were collected on patient demographics, time of the accident, alcohol consumption, helmet use, type of TBI, other related injuries, treatment and assessment at discharge. Results: A total of 28 patients were admitted with TBI related to E-Scooter use, with median age 30 years (Q1-Q3, 20.25-37.25), four individuals under age of 18, majority (64%) were male. In 23 cases the injury mechanism was fall, in 5 cases collision. None were wearing a helmet at time of injury. Alcohol intoxication was evident in over half of the patients (51.5%), with severe intoxication (>1.2ppm) in 75% cases among them. Neurological symptoms upon admission were noted in 50% of cases. All patients had intracranial trauma - 50% brain contusions, 43% traumatic subdural hematoma, almost 30% - epidural hematoma. Craniofacial fractures were evident in 71% of cases, fractures in other parts of body in 3 patients. 6 patients required emergency neurosurgical intervention. Neurological complications were noted in 2 patients, 1 patient died. Conclusions: E-Scooter related accidents result in a significant number of brain and other associated injuries, with notable frequency linked to alcohol influence and lack of helmet use. Prevention campaigns to raise awareness of potential risks and implementation of more strict regulations should be done.

Preprint REVIEW | doi:10.20944/preprints202404.0380.v1

Obesogens in Adolescence. Challenging Aspects and Prevention Strategies.

Marina Nicolaou, Meropi Toumba, Alexandros Kythreotis, Habib Daher, Nicos Skordis

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: endocrine disrupting chemicals; obesogens; obesity; children; adolescents; prevention strategies

Online: 5 April 2024 (06:51:44 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.1317.v1

Inflammatory Bowel Disease Therapies and Acute Liver Injury

Roberto Catanzaro, Francesco Marotta, Azam Yazdani, Morena Sciuto

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Drug-induced liver injury; cholestasis; hepatotoxicity; liver failure.

Online: 19 April 2024 (08:05:31 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.2477.v1

Sublethal Sodium Hypochlorite Exposure: Impact on Resistance-Nodulation-cell Division (RND) Efflux Pump Overexpression, and Cross-Resistance to Imipenem

Ji-Hyun Nam, Jung Sik Yoo

Subject: Public Health And Healthcare, Primary Health Care Keywords: cross-resistance; imipenem antibiotics; NaOCl disinfectant; resistance-nodulation-cell division (RND) efflux pump

Online: 31 July 2024 (08:32:35 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1308.v1

Final Validation of the Quality of Life after Brain Injury for Children and Adolescents after Traumatic Brain Injury (QOLIBRI-KID/ADO) Questionnaire

Nicole von Steinbuechel, Marina Zeldovich, Dagmar Timmermann, Ugne Krenz, Inga K. Koerte, Michaela V. Bonfert, Steffen Berweck, Matthias Kieslich, Marlene Henrich, Knut Brockmann, Anna Buchheim, Maike Roediger, Michael Lendt, Christian Auer, Axel Neu, Alexander Kaiser, Joenna Driemeyer, Sven Greving, Ulrike Wartemann, Daniel Pinggera, Claudius Thome, Joachim Suss, Holger Muehlan, Katrin Cunitz

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: health-related quality of life (HRQoL); pediatric traumatic brain injury (TBI); QOLIBRI-KID/ADO

Online: 22 February 2024 (13:22:09 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202408.2266.v1

Technological Interventions to Implement Prevention and Health Promotion in Cardiovascular Patients

Ayisha Zaka Bashir, Anji Yetman, Melissa Wehrmann

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Health promotion; cardiology; technology; cardiac rehabilitation; telemedicine and telehealth

Online: 30 August 2024 (15:36:00 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202406.1897.v1

Research Progress on Starfish Outbreaks and Their Prevention and Utilization

Liang Qu, Yongxin Sun, Chong Zhao, Maurice R Elphick, Qingzhi Wang

Subject: Biology And Life Sciences, Aquatic Science Keywords: starfish; Asterias amurensis; outbreak; prevention; utilization

Online: 27 June 2024 (12:09:30 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202407.0190.v1

Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges

Riccardo Foti, Gabriele Storti, Marco Palmesano, Maria Giovanna Scioli, Elena Fiorelli, Sonia Terriaca, Giulio Cervelli, Bong Sung Kim, Augusto Orlandi, Valerio Cervelli

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: adipose-derived stem cells; mesenchymal stem cells; ageing; senescence; stem cell therapy; senescence; diabetes; senolytic drugs

Online: 2 July 2024 (10:24:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0958.v1

Comparison of the HBSC Results of the Visegrad Countries with the Health Behavior of Young People with Disabilities Living in Hungary: A Cross-Sectional Study

Agota Barabas, Attila Csaba Nagy, Viktoria Pazmany, Anita Katalin Grestyak Molnarne, Nemeth Agnes, György Jona, Agnes Santha, Peter Takacs, Emil Toldy, Renata Javorne Erdei

Subject: Public Health And Healthcare, Other Keywords: health; health behavior; disability; Visegrad Group

Online: 18 March 2024 (09:10:06 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.1703.v1

Distribution Characteristics and Genesis Mechanism of Ground Fissures in Three Northern Counties of the North China Plain

Chao Xue, Mingdong Zang, Zhongjian Zhang, Nengxiong Xu, Feiyong Wang, Cheng Hong, Guoqing Li, Fujiang Wang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Ground fissures; North China Plain; distribution characteristics; causative mechanism

Online: 25 June 2024 (00:31:48 CEST)

Show abstract| Download PDF| Share

The North China Plain is among the regions most afflicted by ground fissure disasters in China. Recent urbanization has accelerated ground fissure activity in the three counties of the northern North China Plain, posing significant threats to both the natural environment and socioeconomic sustainability. Despite the increased attention, a lack of comprehensive understanding persists due to delayed recognition and limited research. This study conducted field visits and geological surveys across 43 villages and 80 sites to elucidate the spatial distribution patterns of ground fissures in the aforementioned counties. By integrating these findings with regional geological data, we formulated a causative model to explain ground fissure formation. Our analysis reveals a concentration of ground fissures near the Niuxi and Rongxi faults, with the former exhibiting the most extensive distribution. The primary manifestations of ground fissures include linear cracks and patch-shaped collapse pits, predominantly oriented in east-west and north-south directions, indicating tensile failure with minimal vertical displacement. Various factors contribute to ground fissure development, including fault activity, ancient river channel distribution, bedrock undulations, rainfall, and ground settlement. Fault activity establishes a concealed fracture system in shallow geotechnical layers, laying the groundwork for ground fissure formation. Additionally, the distribution of ancient river channels and bedrock undulations modifies regional stress fields, further facilitating ground fissure emergence. Rainfall and differential ground settlement serve as triggering mechanisms, exposing ground fissures at the surface. This research offers novel insights into the causative mechanisms of ground fissures in the northern North China Plain, providing valuable scientific evidence for mitigating ground fissure disasters during the urbanization process in the region.

Preprint ARTICLE | doi:10.20944/preprints202404.1697.v1

The Protective Role of KANK1 in Podocyte Injury

Keiko Oda, Kan Katayama, Liqing Zang, Masaaki Toda, Akiko Tanoue, Ryosuke Saiki, Taro Yasuma, Corina N D'Alessandro-Gabazza, Yasuhito Shimada, Mutsuki Mori, Yasuo Suzuki, Tomohiro Murata, Toshinori Hirai, Karl Tryggvason, Esteban C Gabazza, Kaoru Dohi

Subject: Biology And Life Sciences, Life Sciences Keywords: adriamycin; albuminuria; apoptosis; KANK1; nephrotic syndrome; podocyte

Online: 25 April 2024 (16:53:56 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202403.1614.v1

Molecular Circuits of Immune Sensing and Response to Oncolytic Virotherapy

Darshak K Bhatt, Toos Daemen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: molecular pathways; oncolytic virus; pattern recognition receptors; transcription factors

Online: 26 March 2024 (16:57:15 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.1513.v1

Agricultural Disaster Prevention System: A Review of the Strategies in Taiwan

Ming-Hwi Yao, Yung-Heng Hsu, Ting-Yi Li, Yung-Ming Chen

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: weather forecast; early warning system; disaster prevention; crop; information and communication technology (ICT)

Online: 27 February 2024 (10:29:37 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1542.v1

Attitudes of Healthcare Professionals in an Autonomous Community in Spain towards Paediatric Influenza Vaccination

Jaime Jesús Pérez-Martín, Antonio Iofrío de Arce, Matilde Zornoza-Moreno

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Influenza vaccines; Healthcare professional; Attitude of Healthcare professional; intramuscular vaccine; Inhaled vaccine

Online: 24 April 2024 (07:26:27 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1724.v1

Data Loss Prevention Method Based on Multiprotocol Connectivity for IoT

Hamza Takrouni, Larbi Talbi, Youcef Fouzar

Subject: Engineering, Telecommunications Keywords: Internet of Things, Cloud Computing, Edge Computing, Big Data, IoT Communications Protocols

Online: 29 February 2024 (11:06:12 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1151.v1

Whole-Genome Sequencing Analysis of Antimicrobial Resistance, Virulence Factors, and Genetic Diversity of Salmonella Isolated from Wenzhou, China

Yafang Jin, Yi Li, Shaojie Huang, Chengji Hong, Xucong Feng, Huidi Cai, Yanmei Xia, Shengkai Li, Leyi Zhang, Yongliang Lou, Wanchun Guan

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Salmonella; antimicrobial resistance; pathogenicity islands; cgMLST; Whole genome sequencing

Online: 16 September 2024 (03:20:34 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1426.v1

Improving the Efficiency and Safety of Sentinel Stink Bug Eggs Using X-Rays

Evelyne Hougardy, Ronald P. Haff, Brian N. Hogg

Subject: Biology And Life Sciences, Insect Science Keywords: stink bug; egg parasitism; field monitoring; sentinel eggs; x-ray irradiation; egg sterilization

Online: 18 September 2024 (13:57:26 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0676.v1

Comparison of In Vitro Models for Drug-Induced Liver Injury Assessment

Nam-Ju Kim, Ji-Hyun Bang, Hee Yi, Hyun-Ok Ku, Joong-Sum Kim, Seon-Jong Yun, Byung-Suk Jeon

Subject: Biology And Life Sciences, Toxicology Keywords: 2D and 3D cultures; HepG2; HepaRG; liver injury markers; CYP450

Online: 10 May 2024 (10:42:54 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.1171.v1

Therapeutic Hypothermia for Severe Traumatic Brain Injury: an Overviews of Reviews and Future Prospects

Hitoshi Kobata

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: clinical trials; evacuated hematoma; meta-analysis; therapeutic hypothermia; traumatic brain in-jury

Online: 17 April 2024 (14:32:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0253.v1

Prevalence and Prevention of Clinical Injuries Among Undergraduate Dental Students: A Post-COVID-19 Study

Maria Antoniadou, Maria Chanioti, Asteropi Pantelaki, Antonios Parasiris, Evangelia Piperi, Christos Rahiotis

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: percutaneous injuries; dentists; dental students; COVID-19 pandemic; dental students’ stress; dental school environment

Online: 5 June 2024 (08:25:21 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.1491.v1

Review on the Impact of Iron Tailings on the Environment and Its Prevention and Control Strategies

Yunjie Bai, Weixing Liu, Aimin Yang, Bo Gao, Hao Li, Zhixiao Lin

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Iron tailings; Environmental impact; Water pollution; Air pollution; Resource utilization

Online: 23 May 2024 (10:37:44 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1207.v1

How the Choice of the Starting Time of the Observation Day May Affect Daily Precipitation Amounts and Extremes: Problem Analysis and Adjustment Methods

Francesca Becherini, Claudio Stefanini, Antonio Della Valle, Francesco Rech, Fabio Zecchini, Dario Camuffo

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: daily precipitation; time of observation; time series; aggregation method; adjustment method; hourly dataset; daily extremes

Online: 22 February 2024 (01:19:32 CET)

Show abstract| Download PDF| Supplementary Files| Share

The study of precipitation amount at different time scales constitutes an important issue in climate research and risk assessment. When dealing with daily totals, a frequent but sometimes underestimated problem is at what time the observation day begins. The choice of different starting times may lead to incompatibility between stations and incorrect identification of extreme events. In this work, the problem of temporal misalignment between precipitation datasets characterized by different starting time of the observation day is analyzed. The most widely used adjustment methods (1day and uniform shift) and two methods based on reanalysis (NOAA and ERA5) are evaluated in terms of temporal alignment, precipitation statistics and percentile distributions. As test series, the precipitation amount collected from 9 a.m. local time (09 LT) on the previous day to 09 LT on the target day (9-9 datasets) of the Padua and nearby stations in the period 1993-2022 have been selected. Results show that the reanalysis-based methods, in particular ERA5, outperform the others in temporal alignment, regardless the station. But, for the periods in which reanalysis data are not available, “1day” method, which shifts the daily amount back one calendar day, and “unif” method, which distributes uniformly the daily total from a 2-day moving window surrounding the target date, can be considered valid alternatives. On the other side, concerning the precipitation statistics, the reanalysis-based methods are not the best option, as they increase the precipitation frequency and reduce the mean value over wet days, NOAA much more than ERA5. Nevertheless, the uniform method provides a larger deviation from the original daily series. The use of the series of a station nearby the target one, which is mandatory in case of missing data, gives similar or better results than applying any adjustment method to the 9-9 series. General conclusions can hardly be drawn as they depend on the method and station. For the Padua dataset, the analysis was repeated at monthly and seasonal resolution. In general, the adjustment series show the most relevant changes in the precipitation statistics in summer and less temporal alignment with the original series in summer and autumn, the two seasons mainly affected by heavy rains in Padua. Finally, the percentiles distribution, analyzed for all the methods and stations, indicates that any adjustment method underestimates the percentile values, except ERA5. Only Legnaro, the station most correlated with Padua, gives results like ERA5.

Preprint ARTICLE | doi:10.20944/preprints201702.0107.v1

Maximum Storm Tide Response to the Intensity of Typhoons and Bathymetric Changes along the East Coast of Taiwan

Wen-Cheng Liu, Wei-Bo Chen, Lee-Yaw Lin

Subject: Engineering, Control And Systems Engineering Keywords: maximum storm tide; two-dimensional tide-surge modeling system; east coast of Taiwan; intensity of typhoon; bathymetric rise

Online: 28 February 2017 (13:00:56 CET)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202408.0913.v1

Rugby Union Match Injury Surveillance in Portuguese Top-Tier Competition

Nuno Pinto de Sousa Lopes, António Miguel Cruz-Ferreira, Diana Freitas Torres Lima, Marta Amaral Silva, Luiz Miguel Santiago

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Sports medicine; injury surveillance; Rugby; injury prevention; incidence

Online: 13 August 2024 (11:09:40 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201608.0083.v1

The Joint Use of Multiple Satellite SAR Data and Geotechnical Models for the Study of the Shanghai Ocean-Reclaimed Lands

Antonio Pepe, Manuela Bonano, Qing Zhao, Tianliang Yang, Hanmei Wang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: deformation; interferometry; geotechnical models; non‐linear problem; synthetic aperture radar (SAR); time‐series

Online: 8 August 2016 (14:50:19 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1293.v1

Microbiological Diagnosis – an Important Tool for Prevention and Management of Peri-Implant Infective Diseases

Adrian Țandără, Cristian Funieru, Oana Slușanschi, Cristina Preoteasa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: peri-implant infective diseases; microbiota; antibiogram

Online: 18 September 2024 (04:51:09 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1898.v1

Mild Traumatic Brain Injury in Yucatan Minipigs: Assessing Changes in Approachability/Sociability and Mechanical Nociception Following Central Fluid Percussion Injury

Mark Pavlichenko, Radina Lilova, Amanda Logan-Wesley, Karen Gorse, Audrey D. Lafrenaye

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: mild traumatic brain injury; minipig; central fluid percussion injury; social behavior; mechanical nociception; human approach task; von Frey

Online: 24 September 2024 (11:16:29 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202403.1440.v1

Pediatric Carotid Injury after Blunt Trauma and the Necessity of CT and CTA – a Systematic Literature Review

Lukas Krüger, Oliver Kamp, Katharina Alfen, Jens Theyson, Marcel Dudda, Lars Becker

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: Blunt carotid injury (BCI); blunt trauma; pediatrics; CT; CTA; radiation; radiation dose; radiation risks; carcinogenesis; ultrasound

Online: 25 March 2024 (13:13:56 CET)

Show abstract| Download PDF| Share

Introduction Blunt carotid injuries (BCI) in pediatric trauma are quite rare. Due to the low number of cases, only a few reports and studies have been conducted on this topic. This review will discuss how frequent BCI/ BCVI on pediatric patients after blunt trauma is, what routine diagnostics look like, if a CT/ CTA scan on pediatric patients after blunt trauma is always necessary and if there are any negative health effects? Methods This literature review includes reviews, systematic reviews, case reports and original studies in english language between 1999 and 2020 that have dealt with pediatric blunt trauma and the diagnostics of BCI and BCVI. Furthermore, publications on the risk of radiation exposure on children were included in the study. For literature research, Medline (PubMed) and the Cochrane library were used. Results Pediatric BCI/ BCVI, shows an overall incidence between 0.03 – 0.5% of confirmed BCI/ BCVI cases due to pediatric blunt trauma. 1.1 – 3.5% of pediatric blunt trauma patients underwent CTA to detect BCI. Only 0.17 – 1.2% of all CTA scans shows a positive diagnosis for BCI. In children, the median volume CT dose index on a non-contrast head CT is 33 milligray, a computed tomography angiography needs at least 138 mGy. A cumulative doses of about 50 mGy almost triples the risk of leukemia, and doses of about 60 mGy triples the risk of brain cancer. Discussion Knowing that a BCI could have extensive neurologic consequences for children, it is necessary to evaluate routine pediatric diagnostics after blunt trauma. Computed tomography scans (CT) and computed tomography angiography (CTA) are mostly used in routine BCI diagnostics. However, since radiation exposure in children should be as low as reasonably achievable, it should be asked if other diagnostic methods could be used to identify risk groups. Trauma guidelines and clinical scores like the McGovern score are reflect established BCI screening options, as well as using duplex ultrasound.

Preprint ARTICLE | doi:10.20944/preprints202404.1195.v1

Cholesterol-Modified Anti-Il6 siRNA Reduces the Severity of Acute Lung Injury in Mice

Ivan V. Chernikov, Irina K. Bachkova, Aleksandra V. Sen’kova, Mariya I. Meschaninova, Innokenty A. Savin, Valentin V. Vlassov, Marina A. Zenkova, Elena L Chernolovskaya

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: acute lung injury; inflammation; chemically modified siRNA; IL6; LPS

Online: 18 April 2024 (14:20:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0577.v1

Factors Associated With Complications of Snakebite Envenomation in Health Facilities in the Cascades Region of Burkina Faso, 2016 to 2021

Réné Kinda, Sidikiba Sidibe, Dramane Zongo, Tieba Millogo, Alexandre Delamou, Seni Kouanda

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Snakebite; Envenomation; Complications

Online: 11 June 2024 (08:48:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.0941.v1

Electrolyte Imbalance in Acute Traumatic Brain Injury: Insights from the First 24 Hours

Alina Săcărescu, Mihaela-Dana Turliuc

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: traumatic brain injury; electrolytes; early monitoring; Glasgow Coma Scale; chloride; potassium

Online: 13 August 2024 (14:39:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1724.v1

Mitigative Effect of Graphene Oxide Nanoparticle in Maintaining Gut-Liver Homeostasis against Alcohol Injury

Hiral Aghara, Prashsti Chadha, Palash Mandal

Subject: Biology And Life Sciences, Life Sciences Keywords: Graphene oxide nanoparticles; Gut - liver axis; Alcoholic liver disease; Inflammation; Lipolysis

Online: 26 April 2024 (11:40:51 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0347.v1

The Role of Thromboelastography as a Predictor of Acute Kidney Injury in COVID-19 Patients in ICU

Usi Sukorini, Ira Puspitawati, Yulia Wardhani, Muhammad Roihan Munajih

Subject: Medicine And Pharmacology, Hematology Keywords: thromboelastography; acute kidney injury; COVID-19; hypercoagulable

Online: 6 March 2024 (13:07:01 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.1311.v1

Exosome-Like Systems: From Therapies to Vaccination for Cancer Treatment and Prevention—Exploring the State of the Art

Hamid Heydari Sheikhhossein, Francesca Iommelli, Natalia Di Pietro, Maria Cristina Curia, Adriano Piattelli, Rosanna Palumbo, Giovanni N Roviello, Viviana De Rosa

Subject: Biology And Life Sciences, Life Sciences Keywords: exosomes; cancer vaccines: immune system

Online: 19 April 2024 (08:09:25 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.1588.v1

Cephalometric Evaluation of Children with Short Stature of Genetic Etiology. A Review

George Paltoglou, Nickolas Ziakas, George P. Chrousos, Christos Yapijakis

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: short stature; genetics; genetic syndromes; craniofacial morphology; cephalometric radiograph; growth hormone/insulin-like growth factor 1 axis; epiphyseal growth plate; cartilage extracellular matrix

Online: 24 May 2024 (11:17:53 CEST)

Show abstract| Download PDF| Share

Introduction: A plethora of biological molecules regulate chondrogenesis in the epiphyseal growth plate. Disruptions of quantity and function of these molecules can manifest clinically as stature abnormalities of various etiologies. Traditionally, the growth hormone/insulin-like growth factor 1 (IGF1) axis represents the etiological center of final stature attainment. Of note, little is known about the molecular events that dominate the growth of the craniofacial complex and its correlation with somatic stature. Aim: Given the paucity of the relevant data, this review discusses available information regarding potential applications of lateral cephalometric radiography as a potential clinical indicator of genetic short stature in children. Materials and Methods: A literature search was conducted in the PubMed electronic database using the key words: cephalometric analysis and short stature; cephalometric analysis and achondroplasia; cephalometric analysis and hypochondroplasia; cephalometric analysis and skeletal abnormalities; cephalometr* and SHOX; cephalometr* and CNP; cephalometr* and ACAN; cephalometr* and CNVs; cephalometr* and IHH; cephalometr* and FGFR3; cephalometr* and Noonan syndrome; cephalometr* and “Turner syndrome”; cephalometr* and achondroplasia. Results: In individuals with genetic syndromes causing short stature, linear growth of the craniofacial complex is confined, following the pattern of somatic short stature regardless of its etiology. The angular cephalometric measurements differ from the average height normal individuals and are suggestive of a posterior placement of the jaws and a vertical growth pattern of the face. Conclusion: The greater part of the existing literature regarding cephalometric measurements in short statured children with genetic syndromes provides qualitative data. Furthermore, cephalometric data for individuals affected with specific rare genetic conditions causing short stature, should be the focus of future studies. These quantitative data are required to potentially establish cut-off values to refer for genetic testing based on craniofacial phenotypes.

Preprint ARTICLE | doi:10.20944/preprints202407.0464.v1

Evaluation of Psychosomatic, Respiratory, and Neurocognitive Health in COVID-19 Survivors 12 Months after ICU Discharge

Nicolas Germann, Daria Amozova, Kristina Göhl-Freyn, Tim Fischer, Manuel Frischknecht, Gian-Reto Kleger, Urs Pietsch, Miodrag Filipovic, Martin H. Brutsche, Thomas Frauenfelder, Christian R. Kahlert, Dagmar A. Schmid, Werner C. Albrich

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; Intensive Unit Care; ICU; Predictive Model; Psychosomatic Health

Online: 5 July 2024 (00:23:15 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1101.v1

Hydrogeochemical Characteristics of Earthquake-Related varied-temperature Springs along the Eastern Kunlun Fault Zone, China

Chao Lu, Xiaocheng Zhou, Jiyi Jiang, Jingchao Li, Jing Li, Jing Wu, Xiaoyi Zhu, Jiang Li, Gaoyuan Xing, Shihan Cui

Subject: Environmental And Earth Sciences, Other Keywords: varied-temperature water; hydrogeochemistry; isotopes; seismic precursor; Eastern Kunlun Fault

Online: 19 March 2024 (08:53:36 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202112.0478.v1

Peripheral Nerve Injury Treatments and Advances: One Health Perspective

Bruna Lopes, Patrícia Sousa, Rui Alvites, Mariana Branquinho, Ana Sousa, Carla Mendonça, Luís Miguel Atayde, Ana Lúcia Luís, Artur S. P. Varejão, and Ana Colette Maurício

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Mesenchymal stem cells; Nerve Guide Conduits; Nerve recovery; One Health; Peripheral nerve injury; Secretome

Online: 30 December 2021 (07:35:41 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0168.v1

Preparedness, Prevention, Investigation, and Response to the Emergence of Mpox in Khartoum, Sudan in 2022

Yousif Ali, Emmanuel Edwar Siddig, Mohammed Osman, Nouh Saad Mohamed, Ahmed Musa, Ayman Ahmed

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Mpox; Outbreak; Pandemic Preparedness and Response; global health emergency of international concern; epidemiology, Zoonoses, One Health; Global Health Security

Online: 4 June 2024 (10:43:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0429.v1

Timber-Based Strategies for Seismic Collapse Prevention and Energy Performance Improvement in Masonry Buildings

Davide Cassol, Maja Danovska, Alessandro Prada, And Ivan Giongo

Subject: Engineering, Civil Engineering Keywords: unreinforced masonry; seismic retrofit; energy efficiency; timber panels; timber strong-backs; thermal transmittance u-value; periodic thermal properties; transient method; response factors

Online: 7 November 2023 (09:32:52 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202407.2104.v1

Extracorporeal Shock Wave Therapy (eSWT) in Spinal Cord Injury

Józef Alphons Opara, Robert Dymarek, Mirosław Sopel, Malgorzata Paprocka Borowicz

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: extracorporeal shock wave therapy; neuromodulation; neuroregeneration; recovery; spasticity; spinal cord injury

Online: 26 July 2024 (08:23:20 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.0641.v1

Plant-Derived Bioactive Compounds: Exploring Neuroprotective, Metabolic, and Hepatoprotective Effects for Health Promotion and Disease Prevention

Rosa Direito, Sandra Maria Barbalho, Bruno Sepodes, Maria Eduardo Figueira

Subject: Biology And Life Sciences, Food Science And Technology Keywords: by-products; berries; artichoke; grapevine; gooseberry; polygonoideae plants; olive oil; inflammation

Online: 12 February 2024 (07:41:38 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1456.v1

The Effect of “Proanthocyanidin” on Ischemia-Reperfusion Injury in Skeletal Muscles of Rats

Abdullah Özer, Başak Koçak, Şaban Cem Sezen, Mustafa Arslan, Mustafa Kavutçu

Subject: Medicine And Pharmacology, Surgery Keywords: Ischemia reperfusion; proanthocyanidin; lower extremity; rat; TBARS

Online: 25 March 2024 (08:53:48 CET)

Show abstract| Download PDF| Share

BACKGROUND: Lower limb skeletal muscle ischemia-reperfusion (IR) injury associated with increased morbidity and mortality is common in several clinical situations such as aortic aneurysms repairment, peripheral arterial surgery, vascular injury repairment, and shock. Although it is generally accepted that oxidative stress mediators have a significant role in IR injury, its precise mechanism is still unknown. Anecdotally, it is sustained not only by structural and functional changes in the organ it affects but also by damage to distant organs. The purpose of this report is to illustrate the effect of proanthocyanidin on IR injury. METHODS: In our study, 18 male Wistar albino rats were used. The subjects were divided into three groups of six each. (Group Control-C, Group Ischemia-Reperfusion -IR, Group Ischemia-Reperfusion and Proanthocyanidin-IR-PRO). Intraperitoneal proanthocyanidin was given to the IR and proanthocyanidin groups 30 minutes before laparotomy and 1-hour ischemia led to these two groups. After one hour, reperfusion started. Muscle atrophy-hypertrophy, muscle degeneration-congestion, fragmentation-hyalinization, muscle oval-central nucleus ratio, leukocyte cell infiltration, catalase enzyme activity, and TBARS were all examined in lower-limb muscle samples after one hour of reperfusion. RESULTS: When skeletal muscle samples were evaluated histopathologically, it was discovered that muscle atrophy-hypertrophy, muscle degeneration-congestion, fragmentation-hyalinization, and leukocyte cell infiltration with oval-central nucleus standardization were significantly higher in the IR group than group control and group IR-proanthocyanidin. Besides, oval-central nucleus standardization was significantly higher in the IR and proanthocyanidin group than in the control group. TBARS levels were significantly higher in the IR group than in the control and IR-proanthocyanidin groups while, catalase enzyme activity was found to be significantly lower in the IR group than in the control and IR and proanthocyanidin groups. CONCLUSION: As a consequence of our research, we discovered that proanthocyanidins administered before IR have a protective impact on skeletal muscle in rats. Further research in this area is required.

Preprint ARTICLE | doi:10.20944/preprints202407.1837.v1

Epigenetic Regulation and Molecular Mechanisms of Burn Injury-Induced Nociception in the Spinal Cord of Mice

Zoltan Meszar, Virag Erdei, Peter Szucs, Angelika Varga

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: epigenetics; burn injury; pain; spinal cord; dynorphinergic neuron; histone H3; histone H3 post-translational modification (PTM); p-S10H3; RNA-seq; WES

Online: 24 July 2024 (06:58:30 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0882.v1

Acute Kidney Disease following Acute Kidney Injury in Children—A Retrospective Observational Cohort Study on Risk Factors and Outcomes

Flavia Chisavu, Lazar Chisavu, Viviana Ivan, Adalbert Schiller, Adelina Mihaescu, Luciana Marc, Ramona Stroescu, Ruxandra Maria Steflea, Mihai Gafencu

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: acute kidney disease; children; mortality; chronic kidney disease

Online: 15 April 2024 (04:46:15 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0945.v1

The Effect of Cerium Oxide (CeO2) on Ischemia-Reperfusion Injury in Skeletal Muscle in Mice with Streptozocin-Induced Diabetes

Abdullah Özer, Necmiye Şengel, Ayşegül Küçük, Zeynep Yığman, Çağrı Özdemir, Yiğit Kılıç, Ali Doğan Dursun, Hasan Bostancı, Gülay Kip, Mustafa Arslan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: diabetes mellitus; cerium oxide; skeletal muscle; lower limb; ischemia-reperfusion

Online: 19 February 2024 (14:12:37 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.0684.v1

Epidemiology and Sex-related differences in extracranial complications in ICU patients with traumatic brain injury.

Manuel Cruz-Garcinuño, Raúl Juárez-Vela, Antonio Martínez-Sabater, Elena Chover-Sierra, Juan Luis Sánchez-González, Vicente Gea-Caballero, Maria Luisa Ballestar-Tarín, Ainhoa Serrano Lázaro, Ana Cobos-Rincón, Kapil Laxman Nanwani Nanwani, Regina Ruiz de Viñaspre-Hernández, Manuel Quintana-Diaz

Subject: Public Health And Healthcare, Nursing Keywords: Critical Care; Epidemiology; Brain Injuries; Intensive Care; Craniocerebral Trauma; Data Interpretation

Online: 9 July 2024 (05:45:22 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.1104.v1

Health Benefits of White Mulberry, Sea–Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn — Prevention and Treatment of Cardiovascular Disease

Aleksandra Witkowska, Anna Gryn–Rynko, Patrycja Syrkiewicz, Klaudia Kitala–Tańska, Michał S Majewski

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: white mulberry; sea– buckthorn; garlic; lily of the valley; motherwort; hawthorn

Online: 22 March 2024 (07:33:56 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.2048.v1

Characterization of Hypercapnia Effects in Experimental Models with or without Acute Lung Injury: A Scoping Review

Elber Osorio-Rodriguez, Jose Correa-Guerrero, Dairo Rodelo-Barrios, Maria Bonilla-Llanos, Jhonny Patiño-Patiño, Jesus Viera-Torres, Javier Enamorado-Giraldo, Gustavo Solano-Sopó, Carmelo Dueñas-Castell

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: acute lung injury; acute respiratory distress syndrome; hypercapnia; anti-inflammatory response; biological models

Online: 28 August 2024 (11:01:37 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0450.v2

Amantadine for Traumatic Brain Injury – Supporting Evidence and Mode of Action

Andrzej Dekundy, Gerald Pichler, Reda El Badry, Astrid Scheschonka, Wojciech Danysz

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: traumatic brain injury; clinical; preclinical; mechanism of action; sigma-1; aromatic amino acids decarboxylase; GDNF; NMDA receptors

Online: 11 July 2024 (12:28:17 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202106.0063.v1

Customer Churn - Prevention Model

Julian Eduardo Grijalba Facundo

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Churn 1; customer churn; customer segmentation; churn prevention; predictive churn model; recommendation system engine.

Online: 2 June 2021 (10:03:02 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202404.1562.v1

Clip Closure and PuraStat for Prevention of Clinically Significant Delayed Bleeding after Colorectal Endoscopic Submucosal Dissection: A Prospective, Observational Study

Mihai Ciocirlan, Dana Bilous, Andrei Gila, Daniel Corneliu Leucuta, Daniela Elena Mihaila, Adrian Tulin, Anca Gheorghiu, Elena Tianu, Catalina Vladut

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: endoscopic submucosal dissection; clip closure; PuraStat; muscle retracting sign; colorectal mixed neuroendocrine carcinoma

Online: 24 April 2024 (09:58:17 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201611.0067.v1

Review on Usage of Vancomycin in Livestock and Humans: Maintaining its Efficacy, Prevention of Resistance and Alternative Therapy

P. N. K. WIJESEKARA, W. W. Kumbukgolla, Jayaweera Arachchige Asela Sampath Jayaweera, D. S. Rawat

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: vancomycin; broad view; veterinary use at a glance; rational use; alternatives

Online: 12 November 2016 (11:09:37 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.0100.v1

Neurologic Injury and Post-Traumatic Stress Disorder

Wiley Braxton Gillam V, Nikhil Godbole, Shourya Sangam, Alyssa DeTommaso, Marco Foreman, Brandon Lucke-Wold

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Post-Traumatic Stress Disorder, neurologic injury, traumatic brain injury, subarachnoid hemorrhage, stroke

Online: 4 September 2023 (15:39:56 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202408.1369.v1

Effects of Bioactive Compounds in the Foods for Prevention of Metabolic Syndrome

Lu Huang, Ram B Singh, MA Manal Smail, Ghizal Fatima

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Foods and function; health; functional foods; healthy diet; diseases; micronutrient; nutraceuticals; flavonoids

Online: 20 August 2024 (03:38:26 CEST)

Show abstract| Download PDF| Share

It seems that natural compounds with bioactivity are the food constituents, present in the diets, that may provide protective effects on health due to their biochemical effects. The main benefits appear to be decline in oxidative stress and inflammation that are crucial in the pathogenesis of obesity, diabetes and metabolic syndrome. Apart from anti-inflammatory activity, these molecules also possess antifungal, and anti-infective preventative effects. Further evidence indicate that these bioactive molecules are the constituents, which are known to increase function of the foods. This review aims to emphasize that plant based diet is rich in phytochemicals such as antioxidants, vitamins, minerals, polyphenolics and flavonoids, amino acids and fatty acids, that are able to cause benefits via these compounds. These bioactive molecules can target mechanisms of oxidative stress and inflammation that are crucial in the management of metabolic syndrome. These antioxidant compounds appear to be essential component of plant based diets and are crucial for healthiness. Most investigators have proposed that bioactive compounds act as nutraceuticals which are able to regulate certain patho-physiological mechanisms responsible for metabolic diseases. The bioactive compoundspresent in the plant based diets are primary and secondary metabolites of nutritive and non-nutritive natural components generating health benefits by preventing or managing chronic disease or its symptoms. The bioactive compounds are known for their beneficial effects to health. Despite their small quantity in the diets, these bioactive compounds may trigger certain mechanisms that may cause alteration with improvement in health. It seems that most of the bioactive compounds co-existing in the plant-based diets, may be extremely healthful. However, if they are taken in excess, they can cause toxic effects. There is an urgent need to evaluate each bioactive compound to establish a beneficial quantity and a threshold of toxicity, while treating metabolic syndrome.

Preprint ARTICLE | doi:10.20944/preprints202404.1259.v1

An Overlooked Group of Citizen Scientists in NIS Information: Shell Collectors and Their Contribution to Molluscan NIS Diversity

Argyro Zenetos, Cristiane DELONGUEVILLE, Roland SCAILLET

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Alien species; Mediterranean Sea; mollusca; citizen science; amateur malacologists

Online: 18 April 2024 (12:30:12 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.1414.v1

The Veterinarian’s Role in Biocontainment Research Animal Facilities and Prevention of Spread of Pathogens in Africa

John Kudakwashe Chipangura, Abdussamad M. Abdussamad, David I. Lewis

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Veterinarian; Biocontainment research animal facility; Epicentre; Pathogens; Contamination

Online: 22 April 2024 (14:02:12 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.0894.v1

The Association between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank

Qiuge Zhang, Xueting Qi, Zhaoguo Wang, Dongfeng Zhang, Tong Wang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: sleep disorder; diet; vitamin c; UK Biobank

Online: 11 September 2024 (15:20:48 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202207.0420.v1

Neurotrauma Prevention Review: Improving Helmet Design and Implementation

Michael Goutnik, Joel Goeckeritz, Zackary Sabetta, Tala Curry, Matthew Willman, Jonathan Willman, Theresa Currier Thomas, Brandon Lucke-Wold

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: helmet; military; sport; innovation; secondary injury

Online: 27 July 2022 (10:19:59 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201805.0462.v1

When Polyphenols Meet Sphingolipids: Cancer Prevention and Therapy

Michele Dei Cas, Riccardo Ghidoni

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: sphingolipids; ceramide; flavonoids; resveratrol; genistein; curcumin, nutrients; nutraceuticals; chemotherapeutics

Online: 31 May 2018 (08:26:07 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1231.v1

Suppression of Ventilation-Induced Diaphragm Fibrosis through the Phosphoinositide 3-Kinase-γ in a Murine Bleomycin-Induced Acute Lung Injury Medel

Li-Fu Li, Chung-Chieh Yu, Chih-Yu Huang, Huang-Pin Wu, Chien-Ming Chu, Ping-Chi Liu, Yung-Yang Liu

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: apoptosis; diaphragm fibrosis; phosphoinositide 3-kinase-g; ventilator-induced diaphragm dysfunction

Online: 18 April 2024 (10:06:43 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202405.1896.v1

The Effect of Silymarin on Ischemia-Reperfusion Injury in Skeletal Muscles of Rats

Abdullah Özer, Başak Koçak, Mustafa Arslan, Barış Mardin, Ayşegül Küçük, Şaban Cem Sezen, Mustafa Hakan Zor, Mustafa Kavutçu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: silymarin; malondialdehyde; catalase; ischemia-reperfusion

Online: 29 May 2024 (07:22:24 CEST)

Show abstract| Download PDF| Share

Background and Aim: It is generally accepted that oxidative stress mediators play an important role in ischemia-reperfusion injury(I/R), although the exact mechanism is not fully elucidated. While the impact of silymarin on I/R injury in several tissues, including the myocardial, cerebral, gastric and liver tissue, has been examined, the present state of research on this topic remains insufficient to provide a widely accepted understanding. For this purpose, our objective was to examine the effect of silymarin on muscle tissue in rats subjected to lower extremity I/R injury. Method: After ethics committee approval, 18 male Wistar albino rats weighing between 225-275 g were used. The rats were divided into three groups containing six mice each, Control,Ischemia-Reperfusion and Silymarin-Ischemia/Reperfusion groups. Silymarin was administered intraperitoneally 30 minutes before the procedure.( 100 mg/kg-1 ) In the I/R groups, an atraumatic microvascular clamp was placed in the infrarenal abdominal aorta. After 120 minutes, the clamp was removed and reperfusion was achieved for 120 minutes. In muscle tissue samples taken at the end of the reperfusion period; Malondialdehyde (MDA) levels, catalase (CAT) enzyme activity levels and histopathological parameters were compared. Results: In the histopathological examination, no degeneration was observed in the muscle fibers in the control group, while findings of striated muscle damage such as muscle atrophy hypertrophy, muscle degeneration-congestion, internal of the muscle nucleus-oval-central nucleus, fragmentation-hyalinization and leukocyte cell infiltration were observed in the I/R group. In the S-I/R group, muscle atrophy hypertrophy, internal of the muscle nucleus-oval-central nucleus, fragmentation-hyalinization and leukocyte cell infiltration were observed to improve these damaged areas compared to the I/R group. MDA levels in the I/R group were found to be significantly higher than in the control and S-I/R groups. CAT enzyme activity was found to be significantly higher in the I/R group than in the control group. Conclusion:Our study revealed that the administration of silymarin at a dosage of 100 mg/kg-1 by intraperitoneal injection 30 minutes before ischemia in rats effectively decreased lipid peroxidation and oxidative stress. Additionally, it successfully reduced the injury caused by ischemia/reperfusion in muscle histology.

Preprint REVIEW | doi:10.20944/preprints202401.1748.v1

Community-Based HIV Awareness & Prevention

Samina Khan

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: HIV/AIDS; community-based; awareness; prevention; stigma; empowerment; health promotion

Online: 24 January 2024 (10:41:11 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202407.2238.v3

Challenges and Advances in Cervical Cancer Prevention for HIV-Positive Individuals

Angel Justiz-Vaillant, Darren Gopaul, Odalis Asin-Milan, Rodolfo Arrozarena-Fundora, Reinand Thompson, Sachin Soodeen, Patrick Eberechi Akpaka, Chandrashekhar Unakal

Subject: Biology And Life Sciences, Virology Keywords: HIV; HPV; Prevalence; Vaccination strategy; HPV screening; Cervical intraepithelial neoplasia

Online: 24 September 2024 (12:30:08 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.0369.v2

Biomaterials in Traumatic Brain Injury: Challenges and Perspectives

Sarah Aqel, Najlaa Al-Thani, Mohammad Z. Haider, Samar Abdelhady, Asmaa A. Al Thani, Firas H. Kobeissy, Abdullah A. Shaito

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Traumatic brain injury; TBI; Biomaterials; hydrogels; self-assembling peptides; electrospinning

Online: 26 October 2023 (09:04:43 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202306.1202.v1

Brain Injury: Response to Injury Wound Healing Mechanisms and Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus

Melvin R. Hayden

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Astrogliosis; Brain endothelial cells; Enlarged perivascular spaces; Microgliosis; Perivascular macrophages; Wound Healing

Online: 16 June 2023 (10:04:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202206.0310.v1

Characterization of Calpain and Caspase-6 Generated Glial Fibrillary Acidic Protein Breakdown Products Following Traumatic Brain Injury and Astroglial Cell Injury

Zhihui Yang, Rawad Daniel Arja, Tian Zhu, George Anis Sarkis, Robert Logan Patterson, Pammela Romo, Disa S. Rathore, Emily Jaalouk, Amanda Weissman, Aaron Tin-Chuk Wong, Zhiqun Zhang, Yuan Shi, Richard A. Yost, Ahmed Moghieb, Susan Abbatiello, Claudia S. Robertson, William E. Haskins, Firas Kobeissy, Kevin K. W. Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: astroglial injury; GFAP; calpain; caspase; biomarkers; traumatic brain injury

Online: 22 June 2022 (08:28:02 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202405.2067.v1

Maternal Vaccination for the Prevention of Infantile RSV Disease: An Overview of the Authorized, In-Progress, and Unsuccessful Vaccine Candidates.

Georgios Papazisis, Xanthippi Topalidou

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: infant immunity; maternal antibody transfer; respiratory syncytial virus; maternal immunization; RSV vaccine; clinical trial; safety; immunogenicity

Online: 30 May 2024 (14:23:14 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202406.0886.v1

Aspirin in Primary Prevention: Looking for Who Enjoys It!

Roberta Della Bona, Simona Giubilato, Marco Palmieri, Stefano Benenati, Roberta Rossini, Stefania Angela Di Fusco, Filippo Novarese, Giuseppe Mascia, Nicola Gasparetto, Antonio Di Monaco, Laura Gatto, Filippo Zilio, Carlotta Sorini Dini, Francesco Borrello, Giovanna Geraci, Carmine Riccio, Leonardo De Luca, Furio Colivicchi, Massimo Grimaldi, Michele Massimo Giulizia, Italo Porto, Fabrizio Giovanni Oliva

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aspirin; primary prevention; cardiovascular risk; platelet; bleeding; thrombosis; diabetes; guidelines; cancer

Online: 13 June 2024 (11:51:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0151.v1

Dismantling Barriers to Hepatitis B and Delta Screening, Prevention, and Linkage to Care Among the PWUD Community in Philadelphia

Beatrice Zovich, Catherine Freeland, Holly Moore, Kara Sapp, Anousha Qureshi, Rachel Holbert, Jason Zambrano, Daljinder Bhangoo, Chari Cohen, Richard W. Hass, Amy Jessop

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: hepatitis B; hepatitis delta; people who use drugs; people who inject drugs; harm reduction; population health; viral hepatitis; liver cancer

Online: 2 April 2024 (08:53:02 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202407.2557.v1

Exploring Social Participation Among Adults with Spinal Cord Injury During the Second Wave of the COVID-19 Pandemic in Canada

Noémie Fortin-Bédard, Naomie-Jade Ladry, David Bouchard, Caroline Rahn, Jaimie Borisoff, Shane N. Sweet, Kelly P. Arbour-Nicitopoulos, François Routhier, Krista L. Best

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: COVID-19; Spinal Cord Injury; Manual Wheelchair; Social Participation; Rehabilitation; Social Support

Online: 31 July 2024 (15:19:23 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202407.1157.v1

Hip Muscle Strength Ratios Predicting Groin Injury in Male Soccer Players Using Machine Learning and Multivariate Analysis. A Prospective Cohort Study

Afxentios Kekelekis, Rabiu Muasu Musa, Pantelis T. Nikolaidis, Filipe Manuel Clemente, Eleftherios Kellis

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: hip muscle strength ratios; machine learning; injury prediction; soccer; handheld dynamometer; groin injury

Online: 15 July 2024 (12:07:47 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202407.1805.v1

Capsinoids Promotes an Increase in Enzyme Antioxidative Activity and Prevents the Injury Cardiac Induced by Obesity without Positively Modulate the Cardiac Oxidative Biomarkers

Késsia Cristina Carvalho Santos, Lucas Furtado Domingos, Fabiane Merigueti Nunes, Luisa Martins Simmer, Evellyn Rodrigues Cordeiro, Filipe Martinuzo Filetti, Danilo Sales Bocalini, Camila Renata Corrêa, Ana Paula Lima-Leopoldo, André Soares Leopoldo

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: capsinoids; cardiac remodeling; oxidative stress; antioxidant capacity; obesity

Online: 24 July 2024 (07:27:49 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202408.0132.v1

Advances in Ultrasound-Guided Surgery and Artificial Intelligence Applications in Musculoskeletal Diseases

Soichi Hattori, Rachit Saggar, Eva M Heidinger, Andrew Qi, Joseph Mullen, Brianna Fee, Cortez L Brown, Stephen P Canton, Devon Scott, MaCalus Vinson Hogan

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Musculoskeletal ultrasound; Ultrasound-guided surgery; Artificial Intelligence; Deep Learning; Radiomics

Online: 2 August 2024 (06:04:39 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1960.v1

The Diagnosis, Treatment, and Prevention of Glaucoma – An Update

Karen Allison, Kevin Andrew Morabito, Margaret M. DeAngelis, Deepkumar Patel

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Glaucoma; epidemiology of glaucoma; open angle glaucoma; blindness; disparities in glaucoma treatment and diagnosis

Online: 28 December 2023 (02:26:28 CET)

Show abstract| Download PDF| Share

Search Results

38468 articles found