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Preprint COMMUNICATION | doi:10.20944/preprints202407.1576.v1

Development of Specific Anti-mouse Atypical Chemokine Receptor 4 Monoclonal Antibodies

Miu Hirose, Hiroyuki Suzuki, Rena Ubukata, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mouse ACKR4; monoclonal antibody; peptide immunization; flow cytometry; western blotting

Online: 19 July 2024 (06:39:45 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.1066.v1

Development of Sensitive Anti-mouse CCR5 Monoclonal Antibodies Using the N-terminal Peptide Immunization

Rena Ubukata, Hiroyuki Suzuki, Tomohiro Tanaka, Tsunenori Ouchida, Guanjie Li, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mouse CCR5; monoclonal antibody; peptide immunization; flow cytometry; western blotting

Online: 18 April 2024 (09:29:28 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.1166.v1

C₈Mab-21: A Novel Anti-human CCR8 Monoclonal Antibody for Flow Cytometry

Tomohiro Tanaka, Hiroyuki Suzuki, Guanjie Li, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CCR8, CBIS method, monoclonal antibody, flow cytometry

Online: 19 March 2024 (14:41:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1500.v1

Defucosylated Anti-CD44 Monoclonal Antibodies Exert Antitumor Activities against Esophageal Tumor Xenograft

Kenichiro Ishikawa, Hiroyuki Suzuki, Tomokazu Ohishi, Akira Ohkoshi, Mika K Kaneko, Yukio Katori, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CD44; monoclonal antibody; ADCC; CDC; esophageal tumor; antitumor activity

Online: 26 March 2024 (08:14:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0864.v1

Anti-HER2 cancer-specific mAb, H2Mab-250-hG₁ possesses higher complement-dependent cytotoxicity than trastuzumab

Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2; cancer-specific monoclonal antibody; antitumor effect; complement-dependent cellular cytotoxicity

Online: 11 July 2024 (05:20:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0054.v1

Identification of the Sixth Ig-like Domain of VCAM-1 as a Novel Therapeutic Target in Lung Cancer Cell Invasion

Mi Ra Kim, Ji Hye Jang, Chang Sik Park, Taek-Keun Kim, Youn-Jae Kim, Junho Chung, Hyunbo Shim, In Hyun Nam, Jung Min Han, Sukmook Lee

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: human antibody; invasion; lung cancer; therapeutic target; VCAM-1; VCAM-1-D6

Online: 15 February 2017 (10:45:16 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202311.0216.v1

Epitope Mapping of an Anti-CD44v4 Monoclonal Antibody (C₄₄Mab-108) using Enzyme-Linked Immunosorbent Assay

Hiroyuki Suzuki, Mayuki Tawara, Aoi Hirayama, Nohara Goto, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CD44; CD44 variant 4; monoclonal antibody; epitope; enzyme-linked immunosorbent assay

Online: 3 November 2023 (06:38:38 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202406.0704.v1

Establishment of a Highly-sensitive Anti-EphB2 Monoclonal Antibody Eb2Mab-3 for Flow Cytometry

Rena Ubukata, Hiroyuki Suzuki, Miu Hirose, Hiroyuki Satofuka, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: EphB2; monoclonal antibody; Cell-Based Immunization and Screening; flow cytometry

Online: 11 June 2024 (11:40:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1907.v1

A Broad-Spectrum Antibody-Based Immunochromatographic Assay for Rapid Screening of BADGE and Its Derivatives in Canned Foods

Chundi Yu, Jinnuo Hu, Wei Wu, Yongfei Zhou, Can Zhang, Qingli Yang

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Bisphenol A diglycidyl ether; derivatives; broad-spectrum polyclonal antibodies; AuNPs; immunochromatographic; canned food

Online: 28 September 2023 (17:24:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1052.v1

Optimization, Characterization, and Comparison of Two Luciferase-Expressing Mouse Glioblastoma Models

Louis T Rodgers, Julia A Schulz Pauly, Bryan J Maloney, Anika MS Hartz, Björn Bauer

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: blood-brain barrier; glioblastoma; luciferase; bioluminescence imaging; preclinical; GL261 Red-FLuc; TRP-mCherry-FLuc; AI

Online: 19 March 2024 (06:54:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1841.v1

Detection of ADCC-Supporting Antibodies by NK-92-CD16A Cell Externalization of CD107a: Recognition of Antibody Afucosylation and Assay Optimization

Judith Cruz Amaya, Bruce Walcheck, Julie Smith-Gagen, Vincent C. Lombardi, Dorothy Hudig

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: antibody-dependent cell-mediated cytotoxicity; ADCC; NK-92 cells; CD16A; CD107a; fucosylation; GA101

Online: 26 May 2023 (04:18:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1444.v1

A Sensitive and Specific Monoclonal Antibody based Enzyme‐Linked Immunosorbent Assay for the Rapid Detection of Pretilachlor in Grains and the Environment

Linwei Zhang, Xiaoyang Yin, Hongfei Yang, Hao Wen, Shiyun Han, Xiaoming Pan, Huaming Li, Liangni Qin, Jiaxu Xiao, Long Li, Yu Si, Jixiang Liang, Dapeng Peng

Subject: Biology And Life Sciences, Food Science And Technology Keywords: residue detection; pretilachlor; monoclonal antibody; ic-ELISA

Online: 22 November 2023 (16:49:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0534.v1

AuNP Coupled Rapid Flow-Through Dot-Blot Immuno-Assay for COVID-19 (SARS-CoV-2) Explicit IgG Antibody Revelation

Bijon Kumar Sil, Mohd. Raeed Jamiruddin, Md. Ahsanul Haq, Mohib Ullah Khondoker, Nowshin Jahan, Shahad Saif Khandker, Tamanna Ali, Mumtarin Jannat Oishee, Taku Kaitsuka, Masayasu Mie, Kazuhito Tomizawa, Eiry Kobatake, Mainul Haque, Nihad Adnan

Subject: Biology And Life Sciences, Virology Keywords: COVID-19, SARS-CoV-2, Serological test, Sensitivity, Specificity, Serosurveillance.

Online: 20 April 2021 (11:36:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0238.v1

Anti-CD44 Variant 10 Monoclonal Antibody Exerts Antitumor Activity in Mouse Xenograft Models of Oral Squamous Cell Carcinomas

Kenichiro Ishikawa, Hiroyuki Suzuki, Tomokazu Ohishi, Guanjie Li, Tomohiro Tanaka, Manabu Kawada, Akira Ohkoshi, Mika K. Kaneko, Yukio Katori, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CD44 variant 10; monoclonal antibody; ADCC; CDC; oral cancer; antitumor activity

Online: 6 August 2024 (05:04:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1461.v1

Vitamin D Assay and Supplementation: Still Debatable Issues

MARIO PLEBANI, Martina Zaninotto, Sandro Giannini, Stefania Sella, Maria Fusaro, Giovanni Luigi Tripepi, Maurizio Gallieni, Markus Herrmann, Mario Cozzolino

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Vitamin D; PTH; FGF23; Supplementation; Standardization; Decision limits

Online: 18 July 2024 (11:28:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1311.v1

An In Vitro Assay to Measure Astrocyte-Dependent Synaptic Phagocytosis in Health and Major Depressive Disorder

Diego Julian Vesga-Jimenez, Eugenia Vivi, Barbara Di Benedetto

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Confocal microscopy; astrocytes; phagocytosis; prefrontal cortex; major depressive disorder; Synaptic pruning

Online: 17 September 2024 (10:53:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0409.v1

Clinical Features of Hospitalized Stroke Patients Infected with SARS-CoV-2 Omicron Variant

Hiroshi Kanno, Kazuki Miyazaki, Sachiko Yamada, Shutaro Matsumoto, Yuki Sagehashi, Satoru Takahashi, Yongson Kim, Keiko Namiki, Satoshi Fujii

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Stroke; COVID-19; SARS-CoV-2 Omicron variant; modified Ranking scale; coagulopathy

Online: 9 October 2023 (09:30:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1711.v1

Dermatological Neoplastic Diseases Complicating Treatment with Monoclonal Antibody for Multiple Sclerosis

Floriana Bile, Maddalena Sparaco, Eleonora Ruocco, Giuseppina Miele, Elisabetta Maida, Renato Vele, Davide Mele, Simona Bonavita, Luigi Lavorgna

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Multiple Sclerosis; Skin cancer; Monoclonal antibodies.

Online: 22 July 2024 (11:47:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0098.v1

Clinical and Technical Validation of OncoIndx® Assay – A Comprehensive Genome Profiling Assay for Pan-Cancer Investigations

Aarthi Ramesh, Atul Bharde, Alain D'Souza, Bhagwat Jadhav, Sangeeta Prajapati, Kanchan Hariramani, Madhura Basavalingegowda, Sandhya Iyer, Sumit Halder, Mahesh Deochake, Hrishita Kothavade, Aravindan Vasudevan, Mohan Uttarwar, Jayant Khandare, Gowhar Shafi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Comprehensive Genomic Profiling (CGP); Next Generation Sequencing (NGS); Artificial Intelligence; Cancer Genomics; Targeted gene sequencing

Online: 4 August 2024 (16:28:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0033.v1

Establish and Apply a Safe and Convenient Pseudovirus-Based Assay to Detect Neutralizing Antibodies against Influenza A (H7N9) Virus

Li Zhang, Jing Lu, Jingxing Li, Rong Tang, Haiyan Peng, Fanyue Meng, Yuemei Hu

Subject: Biology And Life Sciences, Virology Keywords: H7N9 avian influenza; pseudovirus; neutralization assay; relative luminescence units (RLU)

Online: 6 January 2017 (10:21:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0686.v1

CleanPage: Fast and Clean Document and Whiteboard Capture

Jane Courtney

Subject: Engineering, Electrical And Electronic Engineering Keywords: document scanning; whiteboard capture; image enhancement; image alignment; image registration; image quality assessment

Online: 28 July 2020 (14:03:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0262.v1

Evaluation of Sensitivity and Applicability of a Droplet Digital Pcr Assay for Simultaneous Detecting Pseudomonas aeruginosa and Pseudomonas fragi in Foods

Ju Huang, Ligong Zhai, Junyin Wang, Xiaotian Sun, Baoshi Wang, Zhaohui Wei

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Pseudomonas aeruginosa; Pseudomonas fragi; simultaneous detection; droplet digital PCR

Online: 3 April 2024 (16:17:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0066.v1

Evaluation of Antibody Titre of Dogs Vaccinated against Canine Distemper in Jos, Plateau State

Kenneth Ikejiofor Ogbu

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: antibody titre; vaccination; dog; canine distemper virus; Jos

Online: 20 September 2016 (10:14:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1291.v1

Development of Smallpox Antibody Testing and Surveillance Following Smallpox Vaccination in the Republic of Korea

Hwachul Shin, SangEun Lee, Myung-Min Choi, Hwajung Yi, Yoon-Seok Chung

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: smallpox; Vaccinia virus; smallpox vaccine; antibody titer; ELISA; bioterrorism

Online: 20 August 2024 (04:55:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0641.v1

Monitoring Viral Entry in Real-Time Using a Luciferase Recombinant Vesicular Stomatitis Virus Producing SARS-CoV-2, EBOV, LASV, CHIKV, and VSV Glycoproteins

Maria Fernanda Lay Mendoza, Marissa Danielle Acciani, Courtney Nina Levit, Christopher Santa Maria, Melinda Ann Brindley

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: entry; kinetics; luciferase; real-time; live assay, vesicular stomatitis virus; Ebola; Lassa; chikungunya; coronavirus.

Online: 25 November 2020 (13:05:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0766.v1

Antibody Recognition to the Hyperglucosylated Adhesin Protein HMW1ct of Non Typeable Haemophilus Influenzae in Rett Syndrome

Feliciana Real Fernandez, Francesca Nuti, Lorenzo Altamore, Mattan Hurevich, Nir Qvit, Eduardo Ponticiello, Paolo Rovero, Joussef Hayek, Anna Maria Papini

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Adhesin protein; N-glucosylation; Antibodies; Immunoenzymatic assay; Rett syndrome ;

Online: 10 July 2024 (04:37:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0166.v1

Infectious Diseases and Secondary Antibody Deficiency in Patients from a Mesoregion of São Paulo State

Luiz Euribel Prestes-Carneiro, Paula Andreia Martins Carrilho, Danimelle Francisco Honorato de Barros Torelli, Jose Antonio Nascimento Bressa, Ana Carolina Gomes Parizi, Pedro Henrique Meirelles Vieira, Fernanda Miranda Caliani Sa, Mauricio Domingues Ferreira

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Secondary Antibody Deficiency; hypo-γ -globulinemia; infectious diseases ;

Online: 4 March 2024 (15:50:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1371.v1

The Influence of Geometry on the Energy Capture of a Point Absorber Wave Energy Converter in the Coast of Mexico

Alejandro Martinez Flores, Ayrton Alfonso Medina Rodríguez, Edgar Mendoza, Rodolfo Silva

Subject: Engineering, Other Keywords: Wave energy converter, heaving buoy, mild slope equation, hydrodynamic response, energy absorption.

Online: 23 February 2024 (11:14:41 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1985.v1

Fatal Diffuse Alveolar Hemorrhage (DAH) Secondary to Monoclonal Antibody Therapy in a Young Patient with Ulcerative Colitis (UC): An Autopsy Case

Antonina Argo, Emanuele Lo Rito, Daniela Guadagnino, Giuseppe Davide Albano, Stefania Zerbo, Ginevra Malta

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: forensic pathology; inflammatory bowel diseases; immunosuppressant; Diffuse Alveolar Hemorrhage; monoclonal antibody, adverse reaction.

Online: 30 April 2024 (14:26:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0012.v1

Bio-Resource Exchange: Study of Prevalence of Antibody Donation and Development of a Web Portal to Facilitate it

Sandeep Subramanian, Madhavi Ganapathiraju

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: data exchange; resource donations; text mining

Online: 5 October 2016 (15:08:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0497.v1

Carbon Capture Using Porous Silica Materials

Sumedha M Amaraweera, Chamila A. Gunathilake, Oneesha H.P. Gunawardene, Rohan S. Dassanayake, Eun-Bum Cho, Yanhai Du

Subject: Chemistry And Materials Science, Nanotechnology Keywords: CO2 Capture Technologies; CO2 Adsorption; Porous Silica; Amine Functionalized Porous Silica; Decarbonization.

Online: 7 June 2023 (07:19:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1481.v1

Flour Treatments Affect Gluten Protein Extractability, Secondary Structure, and Antibody Reactivity

Bruna Mattioni, Michael Tilley, Patricia Matos Scheuer, Niraldo Paulino, Umut Yucel, Donghai Wang, Alicia de Francisco

Subject: Chemistry And Materials Science, Food Chemistry Keywords: wheat; glutenin; gliadin; celiac disease ;

Online: 19 September 2024 (11:59:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1839.v1

Rapid and Simple Morphological Assay for Determination of Susceptibility/Resistance to Combined Ciprofloxacin and Ampicillin, Independently, in Escherichia coli

Isidoro López, Fátima Otero, María del Carmen Fernández, Germán Bou, Jaime Gosálvez, José Luis Fernández García

Subject: Medicine And Pharmacology, Other Keywords: antibiotic combination; bacterial nucleoid; DNA fragments; rapid antibiogram; quinolone; beta-lactam

Online: 28 May 2024 (10:47:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0683.v1

Optimizing Well Placement in Carbon Capture and Storage (CCS): A Bayesian Optimization Framework under Permutation Invariance

Sofianos Panagiotis Fotias, Ismail Ismail, Vassilis Gaganis

Subject: Engineering, Control And Systems Engineering Keywords: CCS; machine learning; Bayesian optimization; Gaussian Process; applied sciences; regression; predictive modelling; well placement optimization

Online: 12 March 2024 (10:26:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0386.v1

Synthesis and Primary Activity Assay of Novel Benitrobenrazide and Benserazide Derivatives

Karolina Juszczak, Wojciech Szczepankiewicz, Krzysztof Walczak

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: schiff bases; benitrobenrazide; benserazide; hexokinase 2; enzyme inhibition

Online: 4 January 2024 (12:30:49 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202205.0159.v1

Characterization and In Vivo Toxicity Assay of Uncoated Silicon Nanoparticles

Konstantin V. Zolotarev, Anton N. Mikhailov, Valeriya I. Nakhod, Maxim A. Sanzhakov, Elena G. Tikhonova, Marina V. Mikhailova

Subject: Chemistry And Materials Science, Biomaterials Keywords: uncoated silicon nanoparticles; aggregation; in vivo toxicity; LC50 for Danio rerio larvae

Online: 12 May 2022 (07:39:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0628.v1

Multiplex Avidity Assay for Evaluating Thyroid Autoantibodies

Elena Savvateeva, Vera Sokolova, Marina Yukina, Nurana Nuralieva, Elena Kulagina, Maria Isaeva, Ekaterina Troshina, Dmitry Gryadunov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: avidity; avidity index (AI); thyroid autoantibodies; protein microarray; multiplex assay; immunoassay

Online: 9 November 2023 (11:05:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1753.v1

Heterozygous SERPINA1 Defects and Their Impact on Clinical Manifestations of Patients with Predominantly Antibody Deficiencies

Styliani Sarrou, Ioanna Voulgaridi, Athanasia Fousika, Katerina Dadouli, Olympia Margaritopoulou, Ioannis Kakkas, Christos Hadjichristodoulou, Fani Kalala, Matthaios Speletas

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Predominantly antibody deficiencies; common variable immunodeficiency; alpha-1-antitrypsin; SERPINA1; liver disease.

Online: 28 March 2024 (09:58:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.0685.v1

Carbon Capture Advancements in Metal-Organic Frameworks

Harshit Mittal, Vivek Yadav, Omkar Kushwaha

Subject: Engineering, Energy And Fuel Technology Keywords: Metal-Organic Frameworks; Organic Chemistry; Carbon Capture; Sustainability; Organo-Conversions

Online: 9 August 2024 (12:18:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0617.v1

An Open-Source Face-Aware Capture System

Md Abdul Baset Sarker, SM Safayet Hossain, Naveenkumar G Venkataswamy, Stephanie Schuckers, Masudul H Imtiaz

Subject: Engineering, Electrical And Electronic Engineering Keywords: Face-aware; Face Quality; Jetson processor; AES encryption; Quality assessment; Passport

Online: 8 December 2023 (13:14:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0187.v1

Characterizing Mitochondrial Capture in an Iberian Shrew

Henry D. Kunerth, Joaquim T. Tapisso, Raul Valente, Maria da Luz Mathias, Paulo C. Alves, Jeremy B. Searle, Rodrigo Vega, Joana Paupério

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Sorex araneus complex; karyotype; introgression; phylogenetics; hybridization; Iberia

Online: 13 October 2022 (07:10:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0435.v1

Evaluation of CO₂/H₂O Co-adsorption Models for the Anion Exchange Resin Lewatit Vpoc 1065 under Direct Air Capture Conditions Using a Novel Lab Setup

Florian Maximilian Chimani, Aditya Anil Bhandari, Andreas Wallmüller, Gerhard Schöny, Stefan Müller, Josef Fuchs

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: Direct air capture; CO₂ adsorption; Co-adsorption; Isotherm modeling; Negative emissions technology

Online: 8 May 2024 (15:17:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0099.v2

Future AI Will Be Able to Predict Antibody-Drug Conjugate Response in Oncology

Navid Sobhani, Alberto D'Angelo, Matteo Pittacolo, Giuseppina Mondani, Daniele Generali

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: artificial intelligence; antibody drug conjugates; prognostic; clinical trials

Online: 5 August 2024 (14:23:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1766.v1

A Bioinformatic Assay of Quercetin in Gastric Cancer

Sergio Raúl Zúñiga-Hernández, Trinidad García-Iglesias, Monserrat Macías-Carballo, Alejandro Pérez-Larios, Yanet Karina Gutiérrez-Mercado, Gabriela Camargo-Hernández, Christian Martín Rodríguez-Razón

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Gastric Cancer; Quercetin; Bioinformatics

Online: 26 June 2024 (00:03:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1792.v1

Synthesis and Characterization of Bromine- and Hydroxyl-Functionalized Polyaminals for CO₂ Capture

Maha M. Alotaibi, Abeer M. Alharthi, Nazeeha S. Alkayal, Maymounah A. Alrayyani

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: porous organic polymer, polyaminal-linked polymers, melamine, surface area, CO2 capture

Online: 25 December 2023 (09:24:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0427.v1

A Motion Capture and Imitation Learning-based Approach to Robot Control

Peteris Racinskis, Janis Arents, Modris Greitans

Subject: Computer Science And Mathematics, Robotics Keywords: imitation learning; motion capture; robotics; artificial neural networks; RNN

Online: 30 June 2022 (11:15:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0249.v1

Detection and Classification of Artifact Distortions in Optical Motion Capture Sequences

Przemysław Skurowski, Magdalena Pawlyta

Subject: Computer Science And Mathematics, Hardware And Architecture Keywords: motion capture; artifact classification; artifact detection; reconstruction

Online: 17 March 2022 (09:32:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0144.v1

IgG Antibody Titers against Ascaris lumbricoides, Strongyloides Stercolaris, and Toxocara canis in Venezuelan Patients with Asthma or COPD

Juan Bautista De Sanctis, Dolores Moreno, Nancy Larocca, Jenny Valetina Garmendia

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COPD; asthma; atopy; eosinophils; IgE; Ascaris lumbricoides; Giardia lamblia; Strongyloides stercolaris; Toxocara canis

Online: 3 September 2024 (08:09:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0392.v1

AI Face-Capture for First-time Passport Application

MD ABDUL BASET SARKER, Masudul H. Imtiaz

Subject: Engineering, Electrical And Electronic Engineering Keywords: Pan-Tilt-Zoom (PTZ) Camera; Jetson Processor; Artificial Intelligence (AI); Biometric Capture; Face Detection; Passport Photos; Young Children

Online: 7 June 2024 (02:43:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0331.v1

Reality Capture of Buildings Using 3D Laser Scanners

Avar Almukhtar, Henry Abanda, Zaid O. Saeed, Joseph H.M. Tah

Subject: Engineering, Architecture, Building And Construction Keywords: 3D Laser Scanners 1; Point-cloud Data 2; Reality Capture; BIM; Refurbishment

Online: 18 January 2021 (12:23:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.0506.v1

Uses and Challenges of Antiviral Polyclonal and Monoclonal Antibody Therapies

Evi B. Struble, Jonathan M.O. Rawson, Tzanko Stantchev, Dorothy Scott, Marjorie Shapiro

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: antiviral therapy; antiviral antibodies; antibody combination therapy; antibody potency; potency assays

Online: 18 April 2023 (08:30:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0246.v2

An Edge Computing and Ambient Data Capture System for Clinical and Home Environments

Pradyumna Byappanahalli Suresha, Chaitra Hegde, Zifan Jiang, Gari D. Clifford

Subject: Engineering, Electrical And Electronic Engineering Keywords: Raspberry Pi; Edge Computing; Ambient Health Monitoring; Privacy-preserving; Bluetooth; Geolocation Tracking; Patient Alarm; Illuminance

Online: 16 March 2022 (05:28:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.1162.v1

Advancements in AI-Driven 3D Reality Capture: Transforming Architectural Digitisation and Modelling

Kai Zhang, Francesco Fassi

Subject: Engineering, Architecture, Building And Construction Keywords: digitalization; artificial intelligence; 3D modelling; object detection; semantic segmentation; machine learning; deep learning

Online: 18 June 2024 (12:15:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0015.v1

Immunization of Nile tilapia (Oreochromis niloticus) Broodstock With Tilapia Lake Virus (TiLV) Inactivated Vaccines Elicits Protective Antibody and Passive Maternal Antibody Transfer

Thao Thu Mai, Pattanapon Kayansamruaj, Chayanit Soontara, Pattarawit Kerddee, Dinh-Hung Nguyen, Saengchan Senapin, Janina Z. Costa, Jorge del- Pozo, Kim D. Thompson, Channarong Rodkhum, Ha Thanh Dong

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: tilapia broodstock; inactivated vaccines; maternal passive immunity; antibody

Online: 4 January 2022 (15:41:19 CET)

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Tilapia lake virus (TiLV), a major pathogen of farmed tilapia, is known to be vertically transmitted. Here, we hypothesize that Nile tilapia (Oreochromis niloticus) broodstock immunized with a TiLV inactivated vaccine can mount a protective antibody response and passively transfer maternal antibodies to their fertilized eggs and larvae. To test this hypothesis, three groups of tilapia broodstock, each containing 4 males and 8 females, were immunized with either a heat-killed TiLV vaccine (HKV), a formalin-killed TiLV vaccine (FKV) (both administered at 3.6 ×106 TCID50 per fish), or with L15 medium. Booster vaccination with the same vaccines was given 3-weeks later, and mating took place 1 week thereafter. Broodstock blood sera, fertilized eggs and larvae were collected from 6-14 weeks post-primary vaccination for measurement of TiLV-specific antibody (anti-TiLV IgM) levels. In parallel, passive immunization using sera from the immunized female broodstock was administered to naïve tilapia juveniles to assess if antibodies induced in immunized broodstock were protective. The results showed that anti-TiLV IgM was produced in the majority of both male and female broodstock vaccinated with either the HKV or FKV and that and that these antibodies could be detected in the fertilized eggs and larvae from vaccinated broodstock. Higher levels of maternal antibody were observed in fertilized eggs from broodstock vaccinated with HKV than those vaccinated with FKV. Low levels of TiLV-IgM were detected in some of the 1-3-day old larvae but were undetectable in 7-14-day old larvae from the vaccinated broodstock, indicating a short persistence of TiLV-IgM in larvae. Moreover, passive immunization proved that antibodies elicited by TiLV vaccination were able to confer 85% to 90% protection against TiLV challenge in naïve juvenile tilapia. In conclusion, immunization of tilapia broodstock with TiLV vaccines could be a potential strategy for the prevention of TiLV in tilapia fertilized eggs and larvae, with HKV appearing to be more promising than FKV for maternal vaccination.

Preprint ARTICLE | doi:10.20944/preprints202405.1072.v1

Serum Antibody Titers against Distemper, Parvovirus and In-fectious Hepatitis in Dogs from Central Spain

JOSE L. BLANCO, ELENA PARRA, SILVIA RUBIES, GUSTAVO ORTIZ-DIEZ, MARTA E GARCIA

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Canine Distemper Virus; Canine Parvovirus; Infectious Hepatitis Virus; IgG level; Vaccicheck

Online: 16 May 2024 (11:55:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0195.v1

Process Simulation of Post-combustion CO₂Capture Using Alkanolamines

Parvane Saeid, Amaani Malek, Mohammad Zeinolabedini, Nejat Rahmanian

Subject: Engineering, Chemical Engineering Keywords: Carbon capture; monoethanolamine; energy consumption; post-combustion; process simulation; Aspen Hysys

Online: 6 May 2024 (08:52:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0539.v1

Predictive Modeling of Co2 Methanation Reaction for Carbon Capture

Osman Okur

Subject: Engineering, Chemical Engineering Keywords: methane; carbon dioxide; modelling; artifical intelligence

Online: 8 September 2023 (04:20:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0130.v1

Zika Virus Non-Structural Protein 1 Antigen-Capture Immunoassay

Brandon J. Beddingfield, Jessica N. Hartnett, Russell B. Wilson, Peter C. Kulakosky, Kristian G. Andersen, Argelia Aybar, Refugio Robles-Sikisaka, Nathan D. Grubaugh, Maria-Zunilla Nunez, Cesar D. Fermin, Robert F. Garry

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Zika virus; non-structural protein 1; site-directed mutagenesis; polyclonal antibodies; antigen-capture ELISA

Online: 5 August 2021 (09:11:41 CEST)

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Working Paper REVIEW

Efficacies of Carbon Based Adsorbents for Carbon Dioxide Capture

Tasmina Khandaker, Muhammad Sarwar Hossain, Palash Kumar Dhar, Md. Saifur Rahman, Md Ashraf Hossain, Mohammad Boshir Ahmed

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: CO2 capture; Activated carbon; Carbon nanomaterials; Adsorption; Surface area.

Online: 8 April 2020 (11:37:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0610.v1

Quantitative Galactose Colorimetric Competitive Assay Based on Galactose Dehydrogenase and Plasmonic Gold Nanostars

Tozivepi Aaron Munyayi, Danielle Wingrove Mulder, Engela Helena Conradie, Barend Christiaan Vorster

Subject: Chemistry And Materials Science, Biomaterials Keywords: Gold nanostars; Enzymatic; Immobilized; Plasmonic; Colorimetric; Detection solution

Online: 10 October 2023 (08:51:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0367.v1

Rosmarinic Acid Multifunctional Sunscreen: Comet Assay and in Vivo Establishment of Cutaneous Attributes

Thalita Marcílio Cândido, Maíra Bueno Ariede, Claudinéia Aparecida Sales de Oliveira Pinto, Wagner Vidal Magalhães, Natália Mencacci Esteves Pedro, Giovana Padovani, Bianca da Silva Sufi, Maria Valéria Robles Velasco, Catarina Rosado, André Rolim Baby

Subject: Medicine And Pharmacology, Dermatology Keywords: rosmarinic acid; anti-inflammatory activity; comet assay; sunscreen; skin biocompatibility

Online: 27 June 2022 (13:22:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1704.v1

Vision System for the Mars Sample Return Capture, Containment and Return System (CCRS)

Brent Jon Bos, David Donovan, John Capone, Chen Wang, Terra Hardwick, Dylan Bell, Yuqing Zhu, Robert Podgurski, Bashar Rizk, Ireneusz Orlowski, Rachel Edison, David Harvey, Brianna Dizzon, Lindsay Haseltine, Kristoffer Olsen, Chad Sheng, Robert Bousquet, Luan Vo, Georgi Georgiev, Kristen Washington, Michael Singer, Stefan Ioana, Anloc Le, Elena Georgieva, Michael Hackett, Michael Ravine, Michael Caplinger, Phillip Coulter, Erin Percy, Charles Torisky, Jean Lauenstein, Kaitlyn Ryder, Michael Campola, Dillon Johnstone, William J. Thomes, Richard G. Schnurr, John McCloskey, Eugenia DeMarco, Ellen Lee, Calinda Yew, Bo Yang, Mingyu Han, Bartosz Blonski

Subject: Engineering, Aerospace Engineering Keywords: Mars; cameras; sample return; space optics

Online: 26 April 2024 (09:33:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0348.v1

Accuracy of Anti-SARS-CoV2 Antibody in Comparison with Surrogate Viral Neutralization Test in Person Living with HIV, Systemic Lupus Erythematosus and Chronic Kidney Disease

Marita Restie Tiara, Chrisan Bimo Prayuda, Tara Titian Maulidya, Hofiya Djauhari, Dadang Suhendar, Rudi Wisaksana, Laniyati Hamijoyo, Rudi Supriyadi, Agnes Rengga Indrati, Bachti Alisjahbana

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; vaccination; antibody; immunoassay; neutralization antibody

Online: 4 April 2024 (05:53:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1878.v1

Development of a Mini-Genome Assay for Species a Rotaviruses

Ola Diebold, Colin Peter Sharp, Blanka Tesla, Hou Wei Chook, Paul Digard, Eleanor R Gaunt

Subject: Biology And Life Sciences, Virology Keywords: rotavirus; minigenome; RNA-dependent RNA polymerase; reporter assay

Online: 29 April 2024 (10:24:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0433.v1

A FRET Based Assay for the Identification of PCNA Inhibitors

Sarah Hardebeck, Sebastian Schreiber, Annika Adick, Klaus Langer, Joachim Jose

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: PCNA; p15; FRET; inhibitor screening; ATLD2; disease; variant; stability; aggregation

Online: 6 July 2023 (11:53:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0604.v2

RT-qPCR Diagnostics: The “Drosten” Sars-Cov-2 Assay Paradigm

Stephen Bustin, Sara Kirvell, Jim F Huggett, Tania Nolan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; reverse transcription; qPCR; SARS-CoV-2; molecular diagnosis

Online: 3 August 2021 (15:34:05 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.0442.v1

Gold Nanoparticle-Based Microfluidics Chips for Capture and Detection of Circulating Tumor Cells

Valber A. Pedrosa, Kangfu Chen, Z. Hugh Fan

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Circulating tumor cells; gold nanoparticles; microfluidics; cell capture

Online: 8 May 2023 (04:41:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0899.v1

Ordinary Muon Capture on ¹³⁶Ba: Comparative Study Using the Shell Model and pnQRPA

Patricia Gimeno, Lotta Jokiniemi, Jenni Kotila, Marlom Ramalho, Jouni Suhonen

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: neutrino physics; muon-capture rates; double beta decays; weak interaction

Online: 25 April 2023 (08:01:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0381.v1

The Application of the Environment Act 2021 Principles to Carbon Capture and Storage

Angelica Rutherford

Subject: Social Sciences, Law Keywords: environmental law principles; carbon capture and storage; energy; climate change

Online: 25 January 2022 (11:41:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0226.v1

Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology

Patrick Bailey, Stuart S. Martin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Circulating Tumor Cells; CTC; Liquid Biopsy; CTM; CTMat; CTC Biology; CTC Capture Technology

Online: 17 May 2019 (16:15:53 CEST)

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Preprint DATASET | doi:10.20944/preprints202003.0011.v1

Extracting the Interfacial Electrostatic Features from Experimentally Determined Antigen and/or Antibody-Related Structures inside Protein Data Bank for Machine Learning-Based Antibody Design

Wei Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: antigen-antibody complex structure; interfacial electrostatic feature; Machine Learning-Based Antibody Design; Protein Data Bank

Online: 1 March 2020 (12:39:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1425.v1

A Nationwide Study of the Delayed Diagnosis and the Clinical Manifestations of Predominantly Antibody Deficiencies and CTLA4-Mediated Immune Dysregulation Syndrome in Greece

Androniki Kapousouzi, Fani Kalala, Styliani Sarrou, Evangelia Farmaki, Nikolaos Antonakos, Ioannis Kakkas, Alexandra Kourakli, Vasiliki Labropoulou, Charikleia Kelaidi, Georgia Tsiouma, Maria Dimou, Theodoros Vassilakopoulos, MICHAEL VOULGARELIS, Ilias Onoufriadis, Eleni Papadimitriou, Sophia Polychronopoulou, Evangelos J Giamarellos-Bourboulis, Argiris Symeonidis, Christos Hadjichristodoulou, Anastasios E. Germenis, Matthaios Speletas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: predominantly antibody deficiencies, common variable immunodeficiency, IgA deficiency, IgG subclass deficiency, CTLA4, diagnosis

Online: 26 February 2024 (12:46:08 CET)

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Predominantly antibody deficiencies (PAD) represent the most common type of primary immu-nodeficiencies in humans, characterized by a wide variation in disease onset, clinical manifesta-tions, complications and outcome. Considering that the prevalence of PAD in Greece is unknown and there is limited knowledge on clinical and laboratory characteristics of affected patients, we conducted a nationwide study, including 153 patients (male/female: 66/87; median age: 43.0 years; range: 7.0-77.0) diagnosed and/or followed-up between April 2007 to September 2023. Furthermore, we classified our cohort into five Groups according to their medical history, im-munoglobulin levels, and CTLA4-mutational status: 123 had common variable immunodeficien-cy (CVID), 12 with CVID-like disease (with a history of a previous B-cell depletion immunother-apy for autoimmune or malignant disease), seven with combined IgA and IgG subclass deficien-cies, five with immune dysregulation syndrome and CTLA4 defects, and six with unclassified hypogammaglobulinemia. We demonstrated a remarkable delay of PAD diagnosis, several years after the onset of related symptoms (median: 9.0 years, range: 0-43.0). Family history of PAD was only 11.8%, with the majority of patients considered sporadic cases. Most patients were diag-nosed in the context of a diagnostic work-up for recurrent infections, or recurrent/resistant auto-immune cytopenias. Interestingly, ten patients (5.6%) had no history of infection, diagnosed due to either recurrent/resistant autoimmunity, or during a work-up of their medical/family history. Remarkable findings included an increased prevalence of lymphoproliferation (60.1%) and atopy (24.2%), while 39 patients (25.5%) developed bronchiectasis and 16 (10.5%) granulomatous dis-ease. Patients with CTLA4 defects displayed a variable clinical phenotype at diagnosis, with four patients diagnosed during a work-up of re-current infections, while one also displayed a massive splenomegaly. Cancer was a common complication in our cohort (25 patients, 16.3%), with B-cell malignancies representing the most common neoplasms (56.7%). Our findings indicate the necessity of awareness about PAD and their complications, aiming for early diagnosis and appropriate management of affected patients

Preprint ARTICLE | doi:10.20944/preprints202404.0550.v1

Techno-Economic Evaluation on Solar-Assisted Post-Combustion CO₂ Capture in Hollow Fiber Membrane Contactors

Junkun Mu, Jinpeng Bi, Yuexia Lv, Yancai Su, Wei Zhao, Hui Zhang, Tingting Du, Fuzhao Li, Hongyang Zhou

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: solar thermal energy; membrane gas absorption; hollow fiber membrane contactor; technical feasibility; economic assessment

Online: 9 April 2024 (07:19:49 CEST)

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Working Paper ARTICLE

Gap Reconstruction in Optical Motion Capture Sequences Using Neural Networks

Przemysław Skurowski, Magdalena Pawlyta

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: motion capture; neural networks; reconstruction; gap filling; FFNN; LSTM; BILSTM; GRU

Online: 3 August 2021 (11:52:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0178.v1

On the Noise Complexity in an Optical Motion Capture Facility

Przemysław Skurowski, Magdalena Pawlyta

Subject: Computer Science And Mathematics, Computer Science Keywords: motion capture; evaluation; noise modelling; noise color; Allan variance; simulated annealing; ant colony optimization

Online: 17 September 2019 (03:59:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0328.v1

Epitope Mapping of the Diphtheria Toxin and Development of an ELISA-Specific Diagnostic Assay

Salvatore Giovanni De-Simone, Larissa Rodrigues Gomes, Paloma Napoleão-Pêgo, Guilherme Curty Lechuga, Jorge Soares de Pina, Flavio Rocha Silva

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Diphtheria toxin; B epitopes; epitope mapping; bi-specific peptides; ELISA; diagnostic performance

Online: 11 March 2021 (16:43:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.1988.v1

Recent Advances in Seaweed Biorefineries and Assessment of Their Potential for Carbon Capture and Storage

Katherine G. Johnston, Abdelfatah Abomohra, Christopher E. French, Abdelrahman S. Zaky

Subject: Biology And Life Sciences, Life Sciences Keywords: Macroalgae; Microalgae; Yeast; Biomass conversion; Climate change; Circular bioeconomy

Online: 28 July 2023 (13:36:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0476.v1

Exhaustive Capture of Ovarian Cancer Transcriptional and Genomic Variant Integrating Canonical and Mapping-Free Protocols

Zhiqin Fu, Chao Lu, Chao Ding, Chengxi Zhou, Tingting Yu, Yue Yang, Liang Shi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Ovarian cancer; mapping-based; mapping-free; SNVs; survival prognosis

Online: 18 December 2020 (15:15:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.0884.v1

Advancements in the Application of CO₂ Capture and 2 Utilization Technologies—a Comprehensive Review

Queendarlyn Adaobi Nwabueze, Smith Leggett

Subject: Engineering, Energy And Fuel Technology Keywords: CO₂ Capture &; Utilization; CO₂ emissions; flue gas; industrial fuels; petrochemicals

Online: 13 June 2024 (05:13:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1459.v1

Carbon Capture and Storage through Upcycling of Suberinic Acid Residues in Wood Composites Finishing

Aleksandra Jeżo, Grzegorz Kowaluk

Subject: Biology And Life Sciences, Forestry Keywords: surface; emission; finishing; biopolymer; filler; bark; suberinic acid; residue; upcycling

Online: 21 July 2023 (13:58:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0342.v1

On the Challenges of Acoustic Energy Mapping Using a WASN: Synchronization and Audio Capture

Emiliano E. García-Unzueta, Caleb Rascon, Paul E. Mendez-Monroy

Subject: Computer Science And Mathematics, Signal Processing Keywords: wireless acoustic sensor network; synchronization; beamforming; acoustic mapping.

Online: 14 April 2023 (03:47:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0212.v4

Sequestering Biomass for Natural, Efficient, and Low-Cost Direct Air Capture of Carbon Dioxide (Version 4)

Jeffrey A. Amelse, Paul K. Behrens

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Carbon Dioxide; Net Zero; Sequestration; Biomass; Direct Capture; Global Warming; Landfills; Forestry

Online: 2 November 2021 (10:53:39 CET)

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Many corporations and governments aspire to become Net Zero Carbon Dioxide by 2030-2050. Achieving this goal requires understanding where energy is produced and consumed, the magnitude of CO₂ generation, and the Carbon Cycle. Many prior proposed solutions focus on reducing future CO₂ emissions from continued use of fossil fuels. Examination of these technologies exposes their limitations and shows that none offer a complete solution. For example, bioethanol is shown to be both carbon and energy inefficient. Direct Air Capture technologies are needed to reduce CO₂ already in the air. The most natural form of Direct Air Capture involves letting nature do the work of creating biomass via photosynthesis. However, it is necessary to break the Carbon Cycle by permanently sequestering that biomass carbon in “landfills” modified to discourage decomposition to CO₂ and methane. Tree leaves and biomass grown on-purpose, such as high yield switchgrass, are proposed as good biomass sources for this purpose. Left unsequestered, leaves decompose with a short Carbon Cycle time constant releasing CO₂ back to the atmosphere. While in any given year, leaves represent a small fraction of a tree’s above ground biomass, leaves can represent a substantial fraction of the total biomass generated by a tree when integrated over a tree’s lifetime. Understanding the chemistry of the distinct phases landfills undergo is the key to minimizing or eliminating decomposition. First, the compact cross-linked structure of cellulose and keeping water out will make it difficult for initial depolymerization to release sugars. Air ingress should be minimized to minimize Phase I aerobic decomposition. pH manipulation can discourage acid formation during Phase II. Lignocellulose is low in nutrients needed for anaerobic decomposition. Inhibitors can be added if needed. The goal is to move quickly to the dormant phase where decomposition stops. The cost for Carbon Capture and Storage (CCS) for growing and sequestering high yield switchgrass is estimated to be lower than CCS for steam reforming of methane hydrogen plants (SRM) and supercritical or combined cycle coal power plants. Thus, sequestration of biomass is a natural, carbon efficient, and low-cost method of Direct Capture. Biomass sequestration can provide CO₂ removal on giga tonnes per year scale and can be implemented in the needed timeframe (2030-2050).

Working Paper REVIEW

Enhancing Natural Cycles in Agro-Ecosystems to Boost Plant Carbon Capture and Soil Storage

Wolfram Buss, Kirsty Yeates, Eelco Rohling, Justin Borevitz

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: carbon sequestration; biochar; soil carbon; basalt; enhanced weathering; agriculture

Online: 3 March 2021 (09:45:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0043.v1

Multi-scale Modeling and Study of Aerosol Growth on Amine-Based CO₂ Capture Absorber

Jia-Lin Kang, Kuan-Ting Liu, David Shan-Hill Wong, Shi-Shang Jang, De-Hao Tsai

Subject: Engineering, Control And Systems Engineering Keywords: aerosol; amine emission; CO2 capture; absorber; particle number concentration

Online: 5 July 2020 (04:41:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0308.v1

Carbon Capture and Storage. A Case Study of Mineral Storage of CO₂ in Greece

Kyriaki Kelektsoglou

Subject: Engineering, Control And Systems Engineering Keywords: carbon capture and storage; mineral carbonation; CO2 sequestration; Greek power plants

Online: 15 October 2018 (12:21:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1084.v1

Lysosomal Cleavable Peptide Linkers in Antibody-Drug Conjugates

Seetharamsing Balamkundu, Chuan Fa Liu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: antibody-drug conjugate; lysosome; cathepsin; legumain; self-immolation; payload release; peptidomimetic; linker

Online: 16 May 2023 (04:51:34 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.1782.v1

Applications of the Microscale Thermophoresis Binding Assay in COVID-19 Research

Damian T. Nydegger, Jonai Pujol-Giménez, Palanivel Kandasamy, Bruno Vogt, Matthias A. Hediger

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; microscale thermophoresis; SLC6A20 amino acid transporter; antiviral agents

Online: 25 May 2023 (09:33:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0122.v1

A Tryptophan-based Assay Method to Search Regulatory Compounds for TCTP

Seri Jo, Eun-Wha Jang, Mi-Sun Kim, Suwon Kim, Kyunglim Lee, Dong Hae Shin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Transcriptionally controlled tumor protein (TCTP); Tryptophan; Florescence; Flavonoid; Native gel electrophoresis

Online: 7 July 2020 (09:49:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0320.v1

Fine Epitope Mapping of the Vibrio cholera Toxins A, B, and P and an ELISA Assay

Salvatore Giovanni De-Simone, Paloma Napoleão-Pêgo, Priscilla Simone Gonçalves, Guilher Curty Lechuga, Sergian Vianna Cardozo, David William Provance, Carlos Meicis Morel, Flavio Rocha Silva

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Cholera toxin; B-cell epitope; peptide microarray; synthetic peptide; MAPs; ELISA

Online: 21 July 2022 (10:32:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0453.v3

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Dominika Skwierawska, Jose Antonio Lopez-Valverde, Marcin Balcerzyk, Antonio Leal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: BNCT; targeted therapy; biological dosimetry; boron imaging; personalized oncology; personalized medicine

Online: 16 May 2022 (15:22:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0214.v1

Spatial Networking Analysis to Capture Local Innovation Flows Towards Inclusive Transition

Carmelina Bevilacqua, Poya Sohrabi, Nourhan Hamdy

Subject: Social Sciences, Urban Studies And Planning Keywords: spatial analysis; innovation flows; urban transition; inclusive; clusters; lagging regions; network analysis, data city.

Online: 14 January 2022 (13:55:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0407.v1

Evaluation of the Diagnostic Values and Utility of Helicobacter Pylori Stool Antigen Lateral Immunochromatography Assay

Shaymaa Abdelmalek, Wafy Hamed, Neven Nagy, Karim Shokry, Hisham Abdelrahman

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: HpSA; H. pylori; diagnostic values; sensitivity; specificity; accuracy; PPV; NPV

Online: 22 November 2021 (14:26:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0052.v1

Efficacy, Pharmacokinetic and Toxicity Profiles of a Broadly SARS-CoV2 Neutralizing Antibody

Silvia Godínez-Palma, Edith González-González, Frida Ramírez-Villedas, Circe Garzón-Guzmán, Luis Vallejo-Castillo, Gregorio Carballo-Uicab, Gabriel Marcelín-Jiménez, Dany Batista, Sonia M. Pérez-Tapia, Juan C. Almagro

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: COVID-19; therapeutic antibody; SARS-CoV-2 Delta; SARS-CoV-2 Omicron; toxicology

Online: 1 August 2023 (11:27:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0166.v1

Antibody Response and Therapy in COVID-19 Patients: Significance in Vaccine Development

Ligong Lu, Hui Zhang, Meixiao Zhan, Jun Jiang, Hua Yin, Danielle J. Dauphars, Shi-You Li, Yong Li, You-Wen He

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19, seroconversion, neutralizing antibody, spike protein, SARS-CoV-2, convalescent plasma, vaccine

Online: 6 August 2020 (12:16:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0853.v1

Assessing the Optimal Contributions of Renewables and Carbon Capture and Storage toward Carbon Neutrality by 2050

Dinh Hoa Nguyen, Andrew Chapman, Takeshi Tsuji

Subject: Engineering, Energy And Fuel Technology Keywords: carbon neutrality; renewables; carbon capture and storage; emission trading system; optimization, socioeconomic analysis.

Online: 10 August 2023 (11:13:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0743.v1

Potential Business Models of Carbon Capture and Storage (CCS) for Oil Refining Industry in Thailand

Waranya Thepsaskul, Wongkot Wongsapai, Jirakom Sirisrisakulchai, Tassawan Jaitiang, Sopit Daroon, Varoon Raksakulkan, Phitsinee Muangjai, Chaichan Ritkrerkkrai, Pana Suttakul, Gengwit Wattakawigran

Subject: Engineering, Energy And Fuel Technology Keywords: carbon capture and storage; carbon neutrality; oil refining industry: Thailand; Climate action

Online: 12 September 2023 (08:52:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0172.v2

Increase Efficiency of Horizontal Subsurface Flow Wetlands by Means of Innovating of the Effluent Capture and Evacuation Device

Pedro Cisterna-Osorio, Gisela Silva-Vasquez, Mauricio Llanos-Baeza, Verónica Lazcano-Castro, Ignacio Fuentes-Ortega

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: artificial wetlands; horizontal wetland; subsurface flow

Online: 5 June 2018 (08:20:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0691.v1

Protein Estimation and Toxicity Determination of Two Fractions of Pakistani Origin Naja oxiana Venom and Its Anti-inflammatory Assay by ROS, TNF-α and IL-β

Farah Aslam, Noor Jahan, Faheema Siddiqui, Mehtab Alam, Meh Jabeen, Nazia Ahmed, Saima Mahmood, Waqas Ahmed Farooqui

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Naja oxiana; anti-inflammatory; carrageenan induced peritonitis; Toxicity testing; LD50

Online: 12 March 2024 (10:04:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.0738.v1

Current State Of Monoclonal Antibody Therapy for Transthyretin Amyloidosis

Avi Chakrabartty

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: transthyretin; amyloidosis; antibody therapy; protein structure; cryo-electron microscopy

Online: 12 August 2024 (02:57:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0307.v1

Overcoming Variants Resistance in Monoclonal Antibody for Antiviral Therapy

Mujahed Mustafa, Awad Alzebair, Hanan Mohamednoor, Ahmed Mohammed

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: monoclonal antibodies; variants resistance; bispecific antibodies; engineered antibodies; antiviral therapy

Online: 6 November 2023 (10:38:14 CET)

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