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Preprint ARTICLE | doi:10.20944/preprints202407.0052.v1

Growth Hormone Upregulates Melanoma Drug Resistance and Migration via Melanoma Derived Exosomes

Prateek Kulkarni, Reetobrata Basu, Taylor Bonn, Beckham Low, Nathaniel Mazurek, John Kopchick

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: growth hormone; exosomes; melanoma; chemotherapy resistance; ABC transporters; N-cadherin; MMP2; pegvisomant

Online: 1 July 2024 (10:12:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1667.v1

Targeting the Melanocortin 1 Receptor in Melanoma: Biological Activity of α-MSH Peptide Conjugates

Ildikó Szabó, Beata Biri-Kovács, Balázs Vári, Ivan Ranđelović, Diána Vári-Mező, Éva Juhász, Gábor Halmos, Szilvia Bősze, József Tóvári, Gábor Mező

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: α-MSH; melanoma; peptide-drug conjugates; in vitro antiproliferative effect; in vivo antitumor activity

Online: 27 November 2023 (08:49:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0130.v1

Interaction Solutions for the Fractional KdVSKR Equations in (1+1)-Dimension and (2+1)-Dimension

Lihua Zhang, Zitong Zheng, Bo Shen, Gangwei Wang, Zhenli Wang

Subject: Physical Sciences, Mathematical Physics Keywords: Korteweg-de Vries Sawada-Kotera-Ramani (KdVSKR) equation; extended Korteweg-deVries (KdV) equation; Sawada-Kotera (SK) equation; finite symmetry groups; Lie symmetry; exact solutions; consistent Riccati expansion (CRE); Hirota bilinear method; fractional derivatives

Online: 2 August 2024 (06:04:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0668.v1

Exploring the Role of BRAFV600E in Melanoma Immune Microenvironment and Its Impact on Modulating the IFN-1 Pathway for Therapeutic Response

Fatima Maria Mentucci, Elisa Ayelén Romero Nuñez, Agustina Ercole, Valentina Silvetti, Jessica Dal Col, María Julia Lamberti

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: BRAFV600E mutation; IFN-1 pathway; melanoma

Online: 12 March 2024 (13:48:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0594.v1

Melatonin Receptor Expression in Primary Uveal Melanoma

Anna Hagström, Ruba Kal Omar, Hans Witzenhausen, Oran Abdiu, Gustav Stålhammar

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Adjuvant treatment; Immunohistochemistry; Melatonin; Metastasis; Prognostic factors; Receptor Expression; Uveal melanoma

Online: 8 July 2024 (09:04:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0688.v1

Combined anti-PD-1 and anti-CTLA-4 Treatment in Stage IV Melanoma Patients: Bicentric Analysis of Real-world Data

Alexandru Dorin Adrian Silași, Anna Carolin Sievert, Paul Danciu, Andrei-Vlad Lefter, Vlad-Adrian Afrăsânie, Daniel Sur

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: melanoma; metastasis; overall survival; progression-free survival; side effects; Nivolumab; Ipilimumab; anti-programmed death-1 antibodies; anti-cytotoxic T-lymphocyte antigen-4 antibodies.

Online: 10 November 2023 (11:05:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0013.v1

Uveal Melanoma Metastasis

Ernesto Rossi, Michela Croce, Francesco Reggiani, Giovanni Schinzari, Marianna Ambrosio, Rosaria Gangemi, Giampaolo Tortora, Ulrich Pfeffer, Adriana Amaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: uveal melanoma; tumorigenesis; molecular classification; targeted therapy; immune checkpoint; tumor heterogeneity

Online: 1 October 2021 (11:54:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0532.v1

Tumor-Infiltrating iNKT Cells Activated through C-Kit/Sca-1 Are Induced by Pentoxifylline, Norcantharidin, and Their Mixtures for Killing murine Melanoma Cells

Maximiliano V.M Correa-Lara, Israel Lara-Vega, Minerva Nájera-Martínez, María Lilia Domínguez-López, Elba Reyes-Maldonado, Armando Vega-López

Subject: Biology And Life Sciences, Toxicology Keywords: NK; iNKT; CD107a+; c+kit+; Lya6A+

Online: 7 September 2023 (10:59:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0006.v1

Regulatory Role of IL-6 in Immune-Related Adverse Events During Checkpoint Inhibitor Treatment in Melanoma

Krishna Pal Singh, Anuj Singh, Olaf Wolkenhauer, Shailendra Kumar Gupta

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Melanoma metastasis; Ulcerative Colitis; Crohn's Disease; Rheumatoid arthritis; Integrated bioinformatics analysis; Virtual screening; Molecular docking; Molecular dynamic simulation

Online: 2 September 2024 (13:12:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0120.v1

Molecular, Genetic Susceptibility and Immunotherapy of Melanoma

Prathvi V Shenoy, Radhakanta Nag, Kiran Kumar Kolathur, Yagya Malik, Sai Manasa Varanasi, Ramcharan Singh Angom, Debabrata Mukhopadhyay

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Melanoma; BRAF mutations; BRAF inhibitors; MEK inhibitors; Immunotherapy

Online: 4 September 2023 (15:46:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1752.v1

Conjunctival Melanoma: A Clinical Review and Update

Karam Butt, Rumana Hussain, Sarah Ellen Coupland, Yamini Krishna

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: conjunctival melanocytic intraepithelial lesions; conjunctival melanoma; ocular oncology, targeted therapy; immunotherapy

Online: 22 July 2024 (16:26:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0227.v1

Frontiers in Pigment Cell and Melanoma Research

Fabian V. Filipp, Stanca Birlea, Marcus W. Bosenberg, Douglas Brash, Pamela B. Cassidy, Suzie Chen, John August D'orazio, Mayumi Fujita, Boon-Kee Goh, Meenhard Herlyn, Arup K. Indra, Lionel Larue, Sancy A. Leachman, Caroline Le Poole, Feng Liu-Smith, Prashiela Manga, Lluis Montoliu, David A. Norris, Yiqun Shellman, Keiran S. M. Smalley, Richard A. Spritz, Richard A. Sturm, Susan M. Swetter, Tamara Terzian, Kazumasa Wakamatsu, Jeffrey S. Weber, Neil F. Box

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: melanocyte; melanoma; oncology; precision medicine; immunotherapy; pigmentation; vitiligo; albinism; melasma; melanin; dermatology; skin; UV; cancer prevention; IFPCS; PASPCR; SMR; IPCC

Online: 13 August 2018 (11:04:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1939.v1

Upregulation of Transferrin Receptor 1 (TfR1) at the Blood‐Brain Barrier by Valproic Acid, but Not of Glucose Transporter 1 (GLUT1) or CD98hc

Steinunn Sara Helgudottir, Kasper Bendix Johnsen, Lisa Greve Routhe, Charlotte LM Rasmussen, Maj Schneider Thomsen, Torben Moos

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: blood‐brain barrier; capillary depletion; CD98hc; cell culture; glucose transporter 1; ICP‐MS; nanoparticle; transferrin receptor; valproic acid

Online: 29 April 2024 (16:53:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0009.v1

A Clinical Outcome of the anti-PD-1 Therapy of Melanoma in Polish Patients Is Mediated by Population-Specific Gut Microbiome Composition

Bernadeta Pietrzak, Katarzyna Tomela, Agnieszka Olejnik-Schmidt, Łukasz Galus, Jacek Mackiewicz, Mariusz Kaczmarek, Andrzej Mackiewicz, Marcin Schmidt

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: microbiome; melanoma; immune checkpoint inhibitor; diet; immunotherapy

Online: 3 October 2022 (12:19:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0624.v1

Real Life Clinical Management and Survival in Cutaneous Malignant Melanoma: the Italian Clinical National Melanoma Registry (CNMR) Experience

Anna Crispo, Maria Teresa Corradin, Erika Giulioni, Antonella Vecchiato, Paolo Del Fiore, Paola Queirolo, Francesco Spagnolo, Vito Vanella, Corrado Caracò, Giulio Tosti, Elisabetta Pennacchioli, Giuseppe Giudice, Eleonora Nacchiero, Pietro Quaglino, Simone Ribero, Monica Giordano, Desire Marussi, Stefania Barruscotti, Michele Guida, Vincenzo De Giorgi, Marcella Occelli, Federica Grosso, Giuseppe Cairo, Alessandro Gatti, Daniela Massa, Laura Atzori, Nicola Calvani, Tommaso Fabrizio, Giuseppe Mastrangelo, Federica Toffolutti, Egidio Celentano, Mario Budroni, Sara Gandini, Carlo Riccardo Rossi, Alessandro A. E. Testori, Giuseppe Palmieri, Paolo A. Ascierto

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: medical record systems; cutaneous malignant melanoma; survival analysis; immunotherapy

Online: 29 October 2020 (16:02:44 CET)

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Background: Cutaneous malignant melanoma (CMM) is one of the most aggressive types of skin cancer. Currently, innovative approaches such as target therapies and immunotherapies have been introduced in clinical practice for the treatment of metastatic CMM. Data of clinical trials and real life studies that evaluate the outcomes of these therapeutic associations are necessary to establish their clinical utility. The aim of this study is to investigate the types of oncological treatments employed in the real-life clinical management of patients with advanced CMM in several Italian centers which are part of the Clinical National Melanoma Registry (CNMR), and the oncological outcomes obtained. Methods: CNMR collects data of patients with a histologically confirmed diagnosis of primary CMM treated in one of the 38 Italian institutions (hospitals, research institutes, etc.) participating in the network. Melanoma-specific survival and Overall survival were calculated. Kaplan-Meier curves and medians of OS and 95% CI are presented overall and by immunotherapy and target treatments. The Log-rank test compared curves by treatments. Multivariate Cox regression models were used to estimate the hazard ratios adjusting for confounders and other prognostic factors. Results: The median follow-up time was 36 months (range 1.2-185.1). 787 CMM were included in the analysis with completed information about therapies.Global immunotherapy showed a significant improved survival compared with all other therapies (p=0.001). 75% was the highest reduction of death reached by nivolumab/pembrolizumab immunotherapy (anti-PD1 HR=0.25 95% CI 0.14-0.42), globally immunotherapy was significantly associated with improved survival, either for anti-CTL A4 monotherapy or combined with anti-PD1 (HR=0.47;95% CI 0.33-0.66 and HR=0.26; 95% CI 0.15-0.46, respectively). Conclusions: The nivolumab/pembrolizumab and the combination of ipilimumab can be considered the best therapy to improve survival in a real-world-population. The CNMR can complement clinical registries with the intent of improving cancer management and standardizing cancer treatment.

Preprint ARTICLE | doi:10.20944/preprints201803.0128.v1

Orthogonal Moment Extraction and Classification of Melanoma Images

Sudhakar Singh, Shabana Urooj

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: moments invariants; ZM,PZM; OFMM; SVM; PSO

Online: 16 March 2018 (05:26:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1362.v1

Personalized 3D Printed Patches for Fast and Safe Radiation Therapy of Non Melanoma Skin Cancer

Michael Friebe, Axel Boese, Castro Nathan J., Dietmar W Hutmacher, Ali Pashazadeh

Subject: Physical Sciences, Radiation And Radiography Keywords: beta.emitting isotopes; superficial skin tumor; 3D printing; transverse dose profile; personalized radiation patch

Online: 22 March 2024 (14:28:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0501.v1

IGF-1 and IGFBP-1, Possible Predictors of Response to Lifestyle Intervention – Results from Randomized Controlled Trials

Nina M.T. Meyer, Stefan Kabisch, Ulrike Dambeck, Caroline Honsek, Margrit Kemper, Christiana Gerbracht, Ayman M. Arafat, Andreas L. Birkenfeld, Peter E. H. Schwarz, Jürgen Machann, Martin A. Osterhoff, Martin O. Weickert, Andreas F. H. Pfeiffer

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: IGF-axis; lifestyle intervention; intervention response; prediabetes

Online: 8 May 2024 (12:45:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1006.v1

Novel Anti-melanoma Leads Are Efficacious in A375 Cell Line Xenograft Melanoma Model in Nude Mice

Sadeeshkumar Velayutham, Ryan Seerattan, Maab Sultan, Trisha Seal, Samaya Danthurthy, Baskaran Chinnapan, Jessica Landi, Kaitlyn Pearl, Aveta Singh, Keiran S.M. Smalley, Julia Zaias, Jun Yong Choi, Dmitriy Minond

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Melanoma; drug discovery; spliceosomal inhibition; BRAF; cell line xenograft; organ histopathology

Online: 15 May 2023 (09:19:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1128.v1

Sphingosine-1-Phosphate Decreases Erythrocyte Dysfunction Induced by Beta-Amyloid

Francesco Misiti, Pierluigi Diotaiuti, Giovanni Enrico Lombardo, Ester Tellone

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Sphingosine-1-phosphate; Band 3; erythrocyte; caspase-3; beta-amyloid; Alzheimer's disease

Online: 22 March 2024 (07:39:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.0621.v1

Targeting the Hippo Pathway in Melanoma

Urszula Kazimierczak, Anna Przybyła, Marianna Smielowska, Tomasz Kolenda, Andrzej Mackiewicz

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Hippo signaling; melanoma; therapy

Online: 9 April 2024 (08:52:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0309.v1

From Lipid Signatures to Cellular Responses: Unraveling the Complexity of Melanoma and Furthering Its Diagnosis and Treatment

Elisa Díaz-Grijuela, Agustín Hernández, Claudia Caballero, Roberto Fernandez, Raquel Urtasun, Marina Gulak, Egoitz Astigarraga, Miguel Barajas, Gabriel Barreda-Gómez

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ; melanoma; comparative oncology; liquid biopsy; mass spectrometry; lipidomics ;

Online: 3 July 2024 (07:11:44 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202408.0304.v1

2-(2,6-Diisopropylphenyl)-1-methylimidazo[1,5-a]quinolin-2-ium tetrafluoroborate

Lyuben Borislavov, Iskra Z. Koleva, Vesela Lozanova, Maria Ivanova, Rumen Lyapchev

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: heterocyclic compounds; imidazolium salts; abnormal N-heterocyclic carbenes; cationic heterocycles

Online: 6 August 2024 (03:30:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1128.v1

The Effects of Novel miRNAs Found in Exosome Vesicles Derived from Cord Blood Stem Cells (CBSCs-EVs) on CHL1 Melanoma Cells Compared to Healthy Control

Mojgan Najafzadeh, Shohreh Jafarinejad, Sajad Falsafi Zadeh, Adi Baumgartner, Mohammad Isreb, Pouria Akhbari, Nader Ghaderi, Farshid Sefat, Saeed Heidari Keshel, Rojan Ghaderi, Diana Anderson, Andrew Wright

Subject: Biology And Life Sciences, Other Keywords: miRNA; Apoptosis; cytotoxic; CBSC-derived exosomes; CHL1 malignant melanoma; fibroblast; lymphocytes

Online: 17 April 2024 (08:55:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0430.v1

Hypoxia-mediated Long Non-coding RNA Fragment Identified in Canine Oral Melanoma through Transcriptome Analysis

Yasunori Hino, Mohammad Arif, Md Mahfuzur Rahman, Al Asmaul Husuna, MD Nazmul Hasan, Naoki Miura

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Hypoxia; melanoma; ncRNA; NGS; dog; metastasis

Online: 4 July 2024 (13:24:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0302.v1

Visualizing CoAtNet Predictions for Aiding Melanoma Detection

Daniel Kvak

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: skin cancer; melanoma; computer-aided diagnostics; image classification; CoAtNet; convolutional neural networks; deep learning

Online: 23 May 2022 (10:55:45 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202308.1962.v1

Piezo1 Activation Prevents Malignant Melanoma Spheroid Formation

Valeria Vasileva, Zuleikha Khairullina, Vladislav Chubinskiy-Nadezhdin

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: piezo1 channel; melanoma; Yoda1; 3D spheroids

Online: 29 August 2023 (09:54:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0149.v1

New Perspectives in Imaging of Uveal Melanoma

Malgorzata Solnik, Natalia Paduszynska, Anna M. Czarnecka, Kamil J. Synoradzki, Yacoub A. Yousef, Tomasz Choragiewicz, Robert Rejdak, Mario Damiano Toro, Katarzyna Dyndor, Michal Fiedorowicz

Subject: Medicine And Pharmacology, Ophthalmology Keywords: uveal melanoma; diagnosis; imaging; MRI; PET; CT; SPECT; OCT; ultrasonography

Online: 8 September 2021 (12:38:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0058.v1

Novel Treatment Modalities of Type 1 Diabetes Mellitus: Opportunities and Challenges

Rasha Aziz Attia Salama, MohamedAnas MohamedFaruk Patni, Shadha Nasser Mohammed Ba-Hutair, Nihal Amir Wadid, Mushirabanu Sharifmiyan Akikwala

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: type1 diabetes mellitus; mesenchymal stem cells; gene therapy; pancreatic islet cell transplantation; teplizumab

Online: 3 June 2024 (09:51:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0046.v1

Assessment of Carbon Flux and Soil Moisture in Wetlands Applying Sentinel-1 Data

Katarzyna Dabrowska–Zielinska, Maria Budzynska, Monika Tomaszewska, Alicja Malinska, Martyna Gatkowska, Maciej Bartold, Iwona Malek

Subject: Environmental And Earth Sciences, Environmental Science Keywords: NEE; backscattering coefficient; LAI; soil moisture

Online: 13 September 2016 (10:12:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0002.v2

Small UAS-Based Wind Feature Identification System Part 1: Integration and Validation

Leopoldo Rodriguez Salazar, Jose A. Cobano, Anibal Ollero

Subject: Engineering, Control And Systems Engineering Keywords: wind prediction; wind estimation; UAS; wind shear; gust; multi-platform integration

Online: 18 January 2017 (09:44:54 CET)

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This paper presents a system for identification of wind features, such as gusts and wind shear. These are of particular interest in the context of energy-efficient navigation of Small Unmanned Aerial Systems (UAS). The proposed system generates real-time wind vector estimates and a novel algorithm to generate wind field predictions. Estimations are based on the integration of an off-the-shelf navigation system and airspeed readings in a so-called direct approach. Wind predictions use atmospheric models to characterize the wind field with different statistical analyses. During the prediction stage, the system is able to incorporate, in a big-data approach, wind measurements from previous flights in order to enhance the approximations. Wind estimates are classified and fitted into a Weibull probability density function. A Genetic Algorithm (GA) is utilized to determine the shaping and scale parameters of the distribution, which are employed to determine the most probable wind speed at a certain position. The system uses this information to characterize a wind shear or a discrete gust and also utilizes a Gaussian Process regression to characterize continuous gusts. The knowledge of the wind features is crucial for computing energy-efficient trajectories with low cost and payload. Therefore, the system provides a solution that does not require any additional sensors. The system architecture presents a modular decentralized approach, in which the main parts of the system are separated in modules and the exchange of information is managed by a communication handler to enhance upgradeability and maintainability. Validation is done providing preliminary results of both simulations and Software-In-The-Loop testing. Telemetry data collected from real flights, performed in the Seville Metropolitan Area in Andalusia (Spain), was used for testing. Results show that wind estimation and predictions can be calculated at 1 Hz and a wind map can be updated at 0.4 Hz. Predictions show a convergence time with a 95% confidence interval of approximately 30 s.

Preprint ARTICLE | doi:10.20944/preprints202405.0255.v1

Updated Risk Factors of Early Endothelial Deregulation in Type-1 Diabetes: A Meta-Analysis

Ranmali Ranasinghe, Michael Mathai, Mohammed Abdullah Alshawsh, Anthony Zulli

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: ; diabetes mellitus; type-1 diabetes; risk factors; biomarkers; therapeutic targets; meta-analysis ;

Online: 6 May 2024 (07:45:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1970.v1

Early Melanoma Detection Based on a Hybrid YOLOv5 and ResNet Technique

Manar Elshahawy, Ahmed Elnemr, Mihai Oproescu, Adriana-Gabriela Schiopu, Ahmed Elgarayhi, Mohammed M. Elmogy, Mohammed Sallah

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Skin cancer classification; melanoma detection; you only look once (YOLO); dermatoscopic im-ages analysis; ResNet50 network

Online: 28 July 2023 (08:35:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0650.v1

Association between IL11RA Overexpression and the Initiation of Melanoma Liver Metastasis

Viktória Koroknai, István Szász, Margit Balázs

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: malignant melanoma; liver metastasis; cytokines; IL11RA; hepatic endothelial cells

Online: 20 April 2023 (10:30:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1686.v1

Lymphocyte Subsets and Immunotherapy Responsiveness in Melanoma Patients: The Oncologist’s Perspective

Clara Martinez Vila, Azucena Gonzalez, Cristina Teixido, Roberto Martin, Francisco Aya, Manel Juan, Ana Maria Arance Fernandez

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Melanoma; Immune checkpoint inhibitors; lymphoid subsets; biomarker; predictive biomarker; prognostic biomarker

Online: 22 July 2024 (09:53:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0693.v1

miR-1 as a Key Epigenetic Regulator in Early Differentiation of Cardiac Sinoatrial Region

Carlos García-Padilla, Estefanía Lozano-Velasco, Virginio García-López, Amelia Aránega, Diego Franco, Virginio García-Martínez, Carmen López-Sánchez

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: miR-1; epigenetic regulator; cardiac sinoatrial region; molecular mechanisms; HDAC4; Calmodulin; pErk2/MAPK1; Mef2c activity; retinoic acid signaling; cardiac development

Online: 12 March 2024 (10:22:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1666.v1

Impact of SARS-CoV-2 (COVID-19) Pandemic on Characteristics and Management of Uveal Melanoma in National Referral Center in Poland

Bożena Romanowska-Dixon, Michał Szymon Nowak, Janusz Śmigielski, Magdalena Dębicka-Kumela

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: uveal melanoma; brachytherapy; proton therapy; enucleation

Online: 27 March 2024 (10:04:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0775.v1

Kinetic Studies on the Interaction of HIV-1 Gag Protein with the HIV-1 RNA Packaging Signal

Constance Rink, Tomas Kroupa, Siddhartha A.K. Datta, Alan Rein

Subject: Biology And Life Sciences, Virology Keywords: HIV-1; packaging signal; Psi; protein-RNA interactions; binding kinetics

Online: 12 August 2024 (10:45:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0373.v2

Tracking of Melanoma Cell Plasticity by Transcriptional Reporters

Anna Vidal, Torben Redmer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Transcriptional reporters; Plasticity; Stemness; NGFR

Online: 13 January 2022 (12:43:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.1545.v1

Soft Tissue Sarcoma Mimicking Melanoma: A Systematic Review

Fortunato Cassalia, Francesco Cavallin, Andrea Danese, Paolo Del Fiore, Claudia Di Prata, Marco Rastrelli, Anna Belloni Fortina, Simone Mocellin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Melanoma; Sarcoma; Mimicking.

Online: 21 June 2023 (11:51:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0286.v1

Micro RNA Transcriptome Profile in Canine Oral Melanoma

Md. Mahfuzur Rahman, Yu-Chang Lai, Al Asmaul Husna, Hui-wen Chen, Yuiko Tanaka, Hiroaki Kawaguchi, Noriaki Miyoshi, Takayuki Nakagawa, Ryuji Fukushima, Naoki Miura

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: MicroRNAs; next generation sequencing; dog; melanoma

Online: 27 August 2019 (16:16:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1541.v1

Advanced Delivery of Curcumin and Nicotinamide: Promising Solutions for Skin Infections and Melanoma

Omar Markab, Zainab Lafi, Naeem Shalan, Hala Al Daghistani, Ali Fahadawi, Razan Madi

Subject: Medicine And Pharmacology, Pharmacy Keywords: Natural compounds; melanoma; skin infection; synergism; liposomes

Online: 21 August 2024 (11:40:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0989.v1

Application of the Generalized Double Reduction Method to the (1+1)-Dimensional Kaup-Boussinesq (K-B) System: Exploiting Lie Symmetries and Conservation Laws

Molahlehi Charles Kakuli

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Generalized double reduction method; conservation laws; Kaup-Boussinesq system; Lie symmetry analysis, exact solutions

Online: 12 September 2024 (13:03:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1316.v1

The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma

Samuel L Blount, Xiaochen Liu, Jeffrey Don McBride

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: melanoma; PRAME; cell biology; cancer; immunotherapy

Online: 17 September 2024 (11:39:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0258.v1

Hybrid Feature Fusion and Machine Learning Approaches for Melanoma Skin Cancer Detection

Md. Mahbubur Rahman, Mostofa Kamal Nasir, Nur A-Alam, Saikat Islam Khan, Shahab Band, Iman Dehzangi, Amin Beheshti, Hamid Alinejad Rokny

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Skin cancer; Deep learning; Hybrid feature extractor; Local binary pattern; Feature extraction

Online: 18 January 2022 (12:43:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0460.v1

Tolerance and Effectiveness of Targeted Therapies in Aged Patients with Metastatic Melanoma

Ondine Becquart, Bastien Oriano, Stéphane Dalle, Laurent Mortier, Marie Thérèse Leccia, Caroline Dutriaux, Sophie Dalac, Henri Montaudié, Julie de Quatrebarbes, Florence Brunet-Possenti, Philippe Saiag, Thierry Lesimple, Marie Beylot-Barry, François Aubin, Pierre Emmanuel Stoebner, Jean Philippe Arnault, Brigitte Dreno, Raphael Porcher, Céleste Lebbé, Bernard Guillot

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: melanoma; targeted therapy; elderly people; side effects

Online: 17 June 2021 (13:59:08 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202408.0158.v1

8-(2-Мethoxyphenyl)-6-methyl-2-(1-methyl-1Hbenzo[d]imidazol-2-yl)quinoline

Maria H. Ivanova, Joana Zaharieva, Martin Tsvetkov, Vesela Lozanova, Bernd Morgenstern, Rumen Lyapchev

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: quinoline; benzimidazole; fluorescence; single crystal diffraction; Suzuki reaction

Online: 2 August 2024 (12:03:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0350.v1

On The Dynamics of a System of Difference Equations x_n+1= x_n-1y_n- 1, y_n+1= y_n-1z_n- 1, z_n+1= z_n-1x_n- 1

Erkan Taşdemir, Yüksel Soykan

Subject: Computer Science And Mathematics, Mathematics Keywords: difference equations; dynamical systems; periodicity; stability; boundedness

Online: 30 October 2019 (07:25:16 CET)

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Preprint REVIEW | doi:10.20944/preprints201709.0146.v2

Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina, Enric Espel

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment

Online: 29 September 2017 (03:17:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1811.v1

Efficacy of Pembrolizumab in Advanced Melanoma: A Narrative Review

Giulio Rizzetto, Edoardo De Simoni, Elisa Molinelli, Annamaria Offidani, Oriana Simonetti

Subject: Medicine And Pharmacology, Dermatology Keywords: advanced melanoma; pembrolizumab; immunotherapy

Online: 26 June 2023 (12:07:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0047.v1

Radiotherapy in Uveal Melanoma: A Review of Ocular Complications

Lamprini Banou, Zoi Tsani, Konstantinos Arvanitogiannis, Maria Pavlaki, Anna Dastiridou, Sofia Androudi

Subject: Medicine And Pharmacology, Ophthalmology Keywords: uveal melanoma; radiotherapy; ocular complications

Online: 2 May 2023 (03:03:31 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202211.0063.v1

In vivo Acute Toxicity Studies of Novel Melanoma Actives

Sadeeshkumar Velayutham, Trisha Seal, Samaya Danthurthy, Julia Zaias, Keiran S.M. Smalley, Dmitriy Minond

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: melanoma; drug discovery; spliceosomal inhibition; acute toxicity; blood chemistry; organ histopathology

Online: 3 November 2022 (01:43:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0014.v1

Conservation Laws and Travelling Wave Solutions for Double Dispersion Equations in (1+1) and (2+1) Dimensions

Maria Luz Gandarias, Maria Rosa Duran, Chaudry Masood khalique

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: conservation laws; Lie symmetries; exact solutions

Online: 3 February 2020 (05:15:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1469.v1

Radiological Changes in Spinal Cord and Brain of Patients with HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

Emily H Stack, Serhat V Okar, Tianxia Wu, Mallory Stack, Yair Mina, Maria I Gaitan, Shila Azodi, William Frazier, Joan Ohayon, Irene Cortese, Daniel S. Reich, Govind Nair, Steven Jacobson

Subject: Public Health And Healthcare, Other Keywords: central nervous system atrophy; spinal cord atrophy; white matter hyperintensities; magnetic resonance imaging; HTLV-1-associated myelopathy

Online: 21 August 2024 (10:16:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1140.v2

The Surprises of Molecular Testing in Neurofibromatosis Type 1: Rare Association between Two Mutational Variants

Aurora Jurca, Codruta Diana Petchesi, Maria Claudia Jurca, Diter Atasie, Dan Bembea, Alexandru Daniel Jurca

Subject: Medicine And Pharmacology, Other Keywords: neurofibromatosis type 1; cone-rod dystrophy; molecular diagnosis; rare association

Online: 12 April 2024 (14:32:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0380.v1

Relationship of SOD-1 Activity in Metabolic Syndrome and/or Frailty Elderly Individuals

Sylwia Dzięgielewska-Gęsiak, Ewa Wysocka, Edyta Fatyga, Małgorzata Muc-Wierzgoń

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: aging; metabolic syndrome; frailty syndrome; SOD-1

Online: 6 August 2024 (06:54:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1498.v1

Characterization of the Bax inhibitor-1 Family in Cauliflower and Functional Analysis of BobBIL4

Xin Liu, Ning Guo, Shasha Li, Mengmeng Duan, Guixiang Wang, Mei Zong, Shuo Han, Zhihan Wu, Fan Liu, Junjie Zhang

Subject: Biology And Life Sciences, Horticulture Keywords: Cauliflower; Bax inhibitor-1; Expression pattern; BobBIL4; Abiotic stress

Online: 21 August 2024 (00:12:19 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.0211.v1

Strategic Investigation of Ligands for Melanoma Therapy: Docking Analysis and Predictive Toxicity Assessment

Ivan Vito Ferrari

Subject: Public Health And Healthcare, Primary Health Care Keywords: ; Melanoma; pKCSM; Docking approach; Diosmin; MAGEB1

Online: 5 December 2023 (04:39:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1160.v1

Predicting Melanoma Immunotherapy Efficacy: Neural Network Models with Gene Expression and Clinical Data

Praveena Sunkara

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: ; artificial neural networks; immune checkpoint blockade; overall survival; progression-free survival ;

Online: 17 May 2024 (09:13:29 CEST)

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Working Paper ARTICLE

KIT Mutation Incidence and Pattern of Skin Melanoma in a Central European Country

Viktoria Doma, Tamas Barbai, Marius Beleaua, Ilona Kovalszky, Erzsebet Raso, Jozsef Timar

Subject: Medicine And Pharmacology, Dermatology Keywords: skin melanoma, KIT mutation, Sanger sequencing

Online: 6 August 2019 (12:33:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0910.v1

Current Status and Molecular Mechanisms of Resistance to Immunotherapy in Oral Malignant Melanoma

Sena Zeynep Usta, Toshihiro Uchihashi, Shingo Kodama, Kyoko Kurioka, Toshihiro Inubushi, Takuya Shimooka, Akinari Sugauchi, Soju Seki, Susumu Tanaka

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: immune checkpoint inhibitor; resistance mechanism; melanoma; oral mucosal melanoma; immunotherapy; immune checkpoint blockade; anti-PD-1; anti-CTLA-4

Online: 17 October 2023 (03:37:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0229.v1

Identification of Cancer Stem Cell Subpopulations in Head and Neck Metastatic Malignant Melanoma

Vithushiya Yoganandarajah, Josie Patel, Bede van Schaijik, Nicholas Bockett, Helen D. Brasch, Erin Paterson, Dalice Sim, Paul F. Davis, Imogen Roth, Tinte Itinteang, Swee T. Tan

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: malignant melanoma; head and neck cancer; cancer stem cell; melanoma metastasis; induced pluripotent stem cell

Online: 19 October 2019 (17:15:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0109.v1

Understanding the Importance of Daily Imaging in the Treatment of Non-Melanoma Skin Cancer with Image Guided Superficial Radiation Therapy

Jeffrey Stricker, Janine Hopkins, Aaron Farberg, Peyton Harris

Subject: Medicine And Pharmacology, Dermatology Keywords: non melanoma skin cancer; basal cell carcinoma; squamous cell carcinoma; image guided superficial radiation therapy; superficial radiation therapy; image guided radiation therapy ;

Online: 1 April 2024 (14:58:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0121.v2

Two Finite Mirror-Image Series Restrict the Non-Trivial Zeros of Riemann’s Zeta Function to Re(s) = 1/2 and the Zeros of its Derivative to Re(s) > 1/2

Anthony Lander

Subject: Computer Science And Mathematics, Mathematics Keywords: Riemann Hypothesis; Dirichlet eta function; Zeta function; prime numbers; number theory; critical-line; critical-strip; symmetry breaking

Online: 22 March 2017 (04:48:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.1955.v1

Preparing for patient-customized N-of-1 Antisense Oligonucleotide Therapy to Treat Rare Diseases

Harry Wilton-Clark, Eric Yan, Toshifumi Yokota

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Antisense oligonucleotide; N-of-1; milasen; atipeksen; valeriasen; rare disease; exon skipping; splice switching; personalized medicine; muscular dystrophy

Online: 29 May 2024 (12:08:10 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0157.v1

Autoimmune Encephalitis Following Check Point Inhibitor Therapy in a Patient with Metastatic Melanoma in Complete Remission

Giuseppe Civardi, Alessia Medioli, Carlotta Braghieri, Massimo Ambroggi, Paolo Immovilli, Simone Orsucci, Paolo Contini, Giuseppe Aronica, Luigi Cavanna

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: autoimmune encephalitis; checkpoint inhibitor; melanoma; pembrolizumab; adverse event

Online: 2 April 2024 (16:18:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0433.v1

Prevalence of Alpha-1 Antitrypsin Deficiency Alleles in a Lithuanian Cohort of Wheezing Small Children

Edita Poluzioroviene, Joanna Chorostowska-Wynimko, Sigita Petraitiene, Arunas Strumila, Adriana Roży, Aneta Zdral, Arunas Valiulis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Alpha-1 Antitrypsin deficiency; children; wheeze; SERPINA1; COPD

Online: 4 July 2024 (11:04:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0117.v1

Targeting GPCRs & their Signaling as a Therapeutic Option in Melanoma

Jeremy H Raymond, Zackie Aktary, Lionel Larue, Véronique Delmas

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: G protein-coupled receptor; mouse models; skin cancer; UVR; drug; network

Online: 10 January 2022 (13:41:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0423.v1

The Circulating Transcriptome as a Source of Biomarkers for Melanoma

Carla Solé, Daniela Tramonti, Maike Schamm, Ibai Goicoechea, María Armesto, Luiza I. Hernandez, Lorea Manterola, Marta Fernandez-Mercado, Karmele Mujika, Anna Tuneu, Ane Jaka, Maitena Tellaetxe, Marc R. Friedländer, Xavier Estivill, Paolo Piazza, Pablo L. Ortiz-Romero, Mark R. Middleton, Charles H. lawrie

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: melanoma; plasma; liquid biopsy; miRNA; mRNA; biomarker; YRNA; RNA species

Online: 19 November 2018 (06:49:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0432.v1

Interleukin-4 (IL-4), Plasminogen Activator Inhibitor-1 (PAI-1) or Receptor for Advanced Glycation End-Products (RAGE) in Bronchial Secretions Cannot Predict Pediatric Ventilator-Associated Pneumonia (VAP)

Argyro Ftergioti, Maria Simitsopoulou, Maria Sdougka, Styliani-Antonia Kallou, Anna-Bettina Haidich, Christina Virgiliou, Georgios Theodoridis, Emmanuel Roilides, Elias Iosifidis

Subject: Medicine And Pharmacology, Internal Medicine Keywords: ventilator-associated pneumonia; biomarkers; pediatric intensive care unit; critically-ill children; ventilator-associated pneumonia; biomarkers; pediatric intensive care unit; critically-ill children

Online: 4 July 2024 (11:00:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1958.v1

Caveolae with GLP-1 and NMDA Receptors as Crossfire Points for the Innovative Treatment of Cognitive Dysfunction with Neurodegenerative Diseases

Moeka Nakashima, Naoko Suga, Sayuri Yoshikawa, Satoru Matsuda

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: caveolae; caveolin; glucagon-like peptide-1; NMDA; autophagy; mitophagy; cognitive dysfunction; Alzheimer's disease

Online: 24 July 2024 (11:52:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0054.v1

Malignant Melanoma: Insights into Cancer Stem Cells, Tumor Microenvironment, and the Renin-Angiotensin System

Ethan J Kilmister, Swee T Tan

Subject: Medicine And Pharmacology, Dermatology Keywords: melanoma; cancer vaccine; mRNA vaccine; renin-angiotensin system; drug repurposing; immunotherapy; embryonic stem cells; cancer stem cells

Online: 3 June 2024 (09:54:04 CEST)

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Working Paper ARTICLE

Genomic Landscape of Patient-matched Tumor and Circulating Cell-free DNA in Metastatic Melanoma

Russell Diefenbach, Jenny Lee, Dario Strbenac, Jean Yang, Alexander Menzies, Matteo Carlino, Georgina Long, Andrew Spillane, Jonathan Stretch, Robyn Saw, John Thompson, Sydney Ch'ng, Richard Scolyer, Richard Kefford, Helen Rizos

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: whole exome sequencing; melanoma; circulating tumor dna

Online: 4 October 2019 (10:35:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0117.v1

Three-Year Analysis of Adjuvant Therapy in Postoperative Melanoma including Acral and Mucosal Subtypes

Yusuke Muto, Yumi Kambayashi, Hiroshi Kato, Satoru Mizuhashi, Takamichi Ito, Takeo Maekawa, Shoichiro Ishizuki, Hiroshi Uchi, Shigeto Matsushita, Yuki Yamamoto, Koji Yoshino, Yasuhiro Fujisawa, Ryo Amagai, Kentaro Ohuchi, Akira Hashimoto, Satoshi Fukushima, Yoshihide Asano, Taku Fujimura¹

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Acral, mucosal, anti-PD-1 Abs, BRAF plus MEK inhibitors, adjuvant therapy

Online: 2 July 2024 (10:51:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0525.v1

Nuclear Matter in 1+1 Dimensions

Robert Douglas Pisarski, Alexei Tsvelik, Marton Lajer, Robert M Konik

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: dense QCD; quarkyonic; Luttinger liquid

Online: 30 September 2021 (15:30:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0960.v1

Evaluation of a Norcantharidin Nanoemulsion Efficacy for Treating B16F1-Induced Melanoma in a Syngeneic Murine Model

Gabriel Martínez-Razo, Patrícia C. Pires, Angelica Avilez-Colin, María Lilia Domínguez-López, Francisco Veiga, Eliezer Conde-Vazquéz, Ana Cláudia Paiva-Santos, Armando Vega-López

Subject: Medicine And Pharmacology, Dermatology Keywords: ; melanoma; nanoemulsion; nanosystems; nanotechnology; norcantharidin; topical administration ;

Online: 12 July 2024 (04:23:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1824.v1

Dipeptidyl Peptidase 9 (DPP9) Depletion From Hepatocytes in Mice Retards Liver Tumour Growth and Increases Intrahepatic Caspase-1 Activation

Jiali Carrie Huang, Xinlin Linda Tong, Michelle Sui Wen Xiang, Badwi B. Boumelhem, Diarmid P Foulis, Mingchang Zhang, Catriona McKenzie, Geoffrey William McCaughan, Thomas Reinheckel, Hui Emma Zhang, Mark Douglas Gorrell

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: dipeptidyl peptidase 9; serine protease; hepatocellular carcinoma; inflammasome; autophagy; histopathology

Online: 29 March 2024 (08:34:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1494.v1

Variability of Sentinel Lymph Node Location in Patients with Trunk Melanoma

Florin Bobirca, Mihaela Leventer, Dragos Eugen Georgescu, Dan Andrei Dumitrescu, Cristina Alexandru, Dragos Serban, Liana Valeanu, Traian Pătrașcu, Anca Bobircă

Subject: Medicine And Pharmacology, Surgery Keywords: trunk melanoma; SLNB; surgical treatment; lymphatic drainage

Online: 21 July 2023 (10:07:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0633.v1

Trend Patterns of Melanoma Skin in Serbia from 1999 to 2020

Natasa K Rancic, Danica B Tiodorovic, Mirko V Ilic, Biljana N Kocic, Natasa S Maksimovic, Ilija D Kocic, Dusan P Miljkovic, Suzana A Otasevic

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: incidence; trend; melanoma of the skin

Online: 9 November 2023 (10:17:20 CET)

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Trend patterns of melanoma skin in Serbia from 1999 to 2020 *Rancic K. Natasa 1,2, Tiodorovic B. Danica 1,4, Ilic V. Mirko 2, Biljana N. Kocic 1,2, Maksimovic S. Natasa 3, Ilija D. Kocic 4, Dusan P. Miljkovic 4, Otasevic A. Suzana 1,2 Introduction. Melanoma of the skin represents about 1% of all skin cancers and it causes nearly 80% of skin cancer deaths. Due to its increasing incidence, particularly in the most developed countries it represents a great challenge for primary prevention. Objective. To explore patterns and analyze incidence trends of melanoma in Central Serbia from 1999 to 2020. Materials and Methods. Descriptive study was done and data were obtained from the Population-based Cancer Registry of Serbia. The joinpoint regression analysis was done to assess the incidence trend of the melanoma skin: the annual percent change (APC) along with its 95% confidence interval (95% CI) was calculated. Results. A total number of 9952 new melanoma cases were registered melanoma (5204 in males and 4748 in females) during the observed period. Males represented 52.3% of all patients, with male to female ratio of incidence 2.09:1. A non significant increasing trend of incidence in males from 1999 to 2013 with APC of 2.53% (95%CI: from -18.2 to 21.9, p=1) and significantly increasing trend from 2013 to 2020 with the APC of 11.29 % (95%CI: from 1.4 to 5.8, p<0.001) was established. An incidence trend in females has stabilized in the whole studied period, with APC of 0.42% (95%CI: from -3.3 to 6.8, p=0.1). Melanoma of the skin was not common before the age of 30. Out of all cases and about of 76% new cases were diagnosed in persons ≥ 50 years of age. Conclusion. The incidence trend of new melanoma cases significantly increase in the whole population from 1999 to 2020. The significant increasing of incidence trend in males and stabilization of incidence trend in females was established. Males had significantlly higher incidence rates than femalesand over of 76% new melanoma cases were diagnosed in persons above 50 years of age.

Preprint REVIEW | doi:10.20944/preprints202111.0110.v1

New Perspectives for Eye-Sparing Treatment Strategies in Primary Uveal Melanoma

Krzysztof Bilmin, Kamil J. Synoradzki, Anna M. Czarnecka, Mateusz J. Spałek, Tamara Kujawska, Malgorzata Solnik, Piotr Merks, Mario Damiano Toro, Robert Rejdak, Michał Fiedorowicz

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: uveal melanoma; HIFU; iontophoresis; electrotherapy; nanoparticles; theranostics.

Online: 5 November 2021 (09:51:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0883.v1

NR5A1/SF-1 Collaborates with Inhibin α and the Androgen Receptor to Reveal a Complex DSD Phenotype

Rawda Naamneh Elzenaty, Chrysanthi Kouri, Idoia Martinez de Lapiscina, Kay Sara Sauter, Francisca Moreno, Núria Camats Tarruella, Christa E. Flück

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: steroidogenic factor 1 (SF-1/NR5A1); inhibin , androgen receptor; differences of sex development (DSD); 46,XY DSD; hypospadias; oligogenicity

Online: 14 August 2024 (09:17:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0433.v1

Astrosat SXT X-ray Spectrum Changes over the 35-Day Cycle in Hercules X-1

Denis Leahy, Riddhiman Sharma

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: binaries; eclipsing — star; neutron— stars; individual (HZ Her/ Her X-1)

Online: 7 June 2024 (08:00:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0222.v1

Exosomes as Novel Diagnostic and Therapeutic Agents for Non-melanoma Skin Cancer: A Systematic Review

Konstantinos Seretis, Elena Boptsi, Anastasia Boptsi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: non-melanoma skin cancer; basal cell carcinoma; cutaneous squamous cell carcinoma; exosomes; extracellular vesicles; biomarker; treatment; diagnosis; prognosis

Online: 3 January 2024 (09:43:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0303.v1

Label-Free Imaging of Melanoma with Confocal Photothermal Microscopy: Differentiation between Malignant and Benign Tissue

Takayoshi Kobayashi, Kazuaki Nakata, Ichiro Yajima, Masashi Kato, Hiromichi Tsurui

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: photothermal microscopy; label-free imaging; melanoma; texture analysis

Online: 19 June 2018 (15:28:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1615.v2

Adherence to Antiretroviral Therapy (ART) Among HIV-1 Patients From Sub-Saharan Africa: A Systematic Review

Pedro Almeida, Carlos Rafael, Victor Pimentel, Ana Abecasis, Cruz Sebastião, Joana Morais

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: HIV-1; Antiretroviral therapy; Treatment adherence; sub-Saharan Africa.

Online: 29 April 2024 (03:59:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0006.v1

Association of JAK2 Haplotype GGCC_46/1 with the Response to Onco-Drug in MPNs Patients Positive for JAK2V617F Mutation

Michela Perrone, Sara Sergio, Amalia Tarantino, Giuseppina Loglisci, Rosella Matera, Davide Seripa, Michele Maffia, Nicola Di Renzo

Subject: Biology And Life Sciences, Life Sciences Keywords: JAK V617F mutation; JAK2 haplotype GGCC_46/1; Myeloproliferative neoplasm

Online: 1 August 2024 (11:04:23 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202311.0970.v1

1-(2,5-Dimethoxy-4-nitrophenyl)piperidine and 1-(2,5-dimethoxy-4-nitrophenyl)pyrroridine

Tanjia M. Syeda, Muadh R. Al-Shaidi, Ibtihal Basri, Mahboub Merzouk, Fawaz Aldabbagh

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: benzimidazolequinone, nitration; nitrobenzene; nucleophilic aromatic substitution

Online: 15 November 2023 (09:06:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1034.v1

Incident Cancer Risk in Patients With Incident Type 2 Diabetes Mellitus in Hungary (Part 1)

Zsolt Abonyi-Tóth, György Rokszin, Ibolya Fábián, Zoltán Kiss, György Jermendy, Péter Kempler, Csaba Lengyel, István Wittmann, Gergő A. Molnár, Gábor Sütő

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Type 2 diabetes mellitus; epidemiology; cancer; incidence; new-onset diabetes

Online: 19 February 2024 (10:20:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0190.v1

Equine Herpesvirus Type 1 ORF76 Encoding US9 as a Neurovirulence Factor in the Mouse Infection Model

Mohamed Nayel, Samy Kasem, Noriko Fukushi, Nagwan El-Habashi, Ahmed Elsify, Akram Salama, Hany Hassan, Tokuma Yanai, Kenji Ohya, Hideto Fukushi

Subject: Biology And Life Sciences, Virology Keywords: EHV-1; neurovirulence; US9; ORF76

Online: 3 September 2024 (09:42:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1768.v1

Phase Transition Analysis of the Potts-SOS Model with Spin Set {-1,0, 1} on the Cayley Tree

Hasan Akin

Subject: Computer Science And Mathematics, Mathematics Keywords: Potts-SOS model; Gibbs measure; phase transition; stability analysis

Online: 26 August 2024 (03:02:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0670.v1

Biomarker Discovery for Meta-Classification of Melanoma Metastatic Progression using Transfer Learning

Jose Marie Antonio Miñoza, Jonathan Adam Rico, Pia Regina Fatima Zamora, Manny Bacolod, Reinhard Laubenbacher, Romulo de Castro

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: melanoma; biomarker; transfer learning; ensemble model; bias; machine learning

Online: 27 May 2021 (13:20:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1354.v1

Assessment of Metabolic Imaging Biomarkers for MEK Inhibition Therapy Response in Melanoma

Pradeep Kumar Gupta, Stepan Orlovskiy, Fernando Arias-Mendoza, David S. Nelson, Kavindra Nath

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: melanoma; trametinib; 1H/31P magnetic resonance spectroscopy; oxygen consumption rate; extracellular acidification rate; glucose uptake; lactate production.

Online: 19 June 2024 (14:19:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0681.v1

Impact of Radiotherapy on Circulating Regulatory T-Cell Levels in Melanoma Patients

Sylwia Szablewska, Anna A Brożyna, Lidia Gackowska, Anna Wołowiec, Elżbieta Zawada, Zofia Durczynska, Krzysztof Roszkowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: radiotherapy; melanoma; regulatory T cells; immunotherapy

Online: 9 January 2024 (06:14:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1119.v1

Immunogenicity of the Monovalent Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine against XBB.1.5, BA.2.86, and JN.1 Sublineages: A Phase 2/3 Trial

Juleen Gayed, Vishva Bangad, Xia Xu, Federico Mensa, Mark Cutler, Özlem Türeci, Uǧur Şahin, Kayvon Modjarrad, Kena A. Swanson, Annaliesa S. Anderson, Alejandra Gurtman, Nicholas Kitchin

Subject: Public Health And Healthcare, Primary Health Care Keywords: BA.2.86; BNT162b2; booster; COVID-19; JN.1; Omicron; SARS-CoV-2; vaccine; variant-adapted; XBB.1.5

Online: 17 April 2024 (08:24:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0604.v1

Wolfram Syndrome 1: A Neuropsychiatric Perspective on a Rare Disease

Valerio Caruso, Accursio Raia, Luciana Rigoli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Wolfram syndrome 1; WFS1 gene; neuropsichiatric disorders; new findings in Wolfram syndrome 1.

Online: 8 July 2024 (10:01:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0917.v1

Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

Stefania Vlachou, Alexandre Loume, Catherine Giannopoulou, Evangelos Papathanasiou, Alkisti Zekeridou

Subject: Public Health And Healthcare, Other Keywords: Diabetes mellitus; periodontitis; type 1 diabetes mellitus; molecular mechanisms; cellular mechanisms; oral microbiota; host immune response; oxidative stress; periodontal disease

Online: 15 April 2024 (07:26:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1518.v1

Whole Genome Sequencing of the Entomopathogenic Fungus Lecanicillium lecanii, KMZW-1 and Its Efficacy against Bactrocera dorsalis

Junfu Yu, Mehboob Hussain, Mingqi Wu, Chunlan Shi, Shini Li, Yuanxia Ji, Sikandar Hussain, Deqiang Qin, Chun Xiao, Guoxing Wu

Subject: Biology And Life Sciences, Insect Science Keywords: Lecanicillium lecanii; whole genome sequencing; entomopathogenic fungus; Bactrocera dorsalis

Online: 19 July 2024 (02:30:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0214.v1

Dynamic Effective Elasticity of Melanoma Cells Under Shear and Elongational Flow Confirms Estimation From Force Spectroscopy

Anna Martina Jötten, Simon Neidinger, Julia K. Tietze, Julia Welzel, Christoph Westerhausen

Subject: Physical Sciences, Applied Physics Keywords: melanoma cells; elasticity; AFM; microfludics; force spectroscopy

Online: 13 September 2021 (14:14:47 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202310.0772.v1

Reproducible Method for 1-methylcylopropene (1-MCP) Application and Quantitation for Post-harvest Research

Evan Stowe, D Scott Mattinson, Jacob Michael Blauer, Amit Dhingra

Subject: Biology And Life Sciences, Horticulture Keywords: fruit ripening; post-harvest; ethylene; 1-methylcylcopropene

Online: 12 October 2023 (05:35:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0397.v1

Erythrocytes of Nonalcoholic Steatohepatitis Patients Contain Decreased Arginase-1 and Thrombospondin-1, and Increased Phosphatidylethanolamine Levels

Charalampos Papadopoulos, Konstantinos Mimidis, Ioannis Tentes, Konstantinos Anagnostopoulos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: erythrocyte; non alcoholic steatohepatitis; immunometabolism; thrombospondin-1; arginase-1; phosphatidylethanolamine; metabolic inflammation ;

Online: 17 April 2023 (04:22:12 CEST)

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