Effective and rapid mixing is essential for various chemical and biological assays. The present work reports a simple and low-cost micromixer based on magnetofluidic actuation. The device takes advantage of magnetoconvective secondary flow, a bulk flow induced by an external magnetic field, for mixing. A paramagnetic stream of diluted ferrofluid and a non-magnetic stream are introduced to a straight microchannel. A permanent magnet placed next to the microchannel induced a non-uniform magnetic field. The magnetic field gradient and the mismatch in magnetic susceptibility between the two streams create a body force, which leads to rapid and efficient mixing. The micromixer reported here could achieve a high throughput and a high mixing efficiency of 90 % in a relatively short microchannel.

Nanoporous membranes promise energy-efficient water desalination. Hexagonal boron nitride (h-BN), like graphene, exhibits outstanding physical and chemical properties, making it a promising candidate for water treatment. We employed Car–Parrinello molecular dynamics simulations to establish accurate modeling of Na+ and Cl- permeation through hydrogen passivated nanopores in graphene and h-BN membranes. In these complex systems the classical potentials cannot properly account for the physics at play. We demonstrate that ion separation works well for the h-BN by imposing a barrier of 0.13 eV and 0.24 eV for Na+ and Cl- permeation respectively, compared to the graphene where the Cl- ion faces a negative barrier of 0.68 eV and is prone toward blockade and Na+ permeation is associated with a slightly negative barrier of 0.03 eV. From the change in the solvation shell, we get the following trend: Na/h-BN > Na/G > Cl/G > Cl/h-BN. We argue that the trend in the permeation barrier changes to Cl-h-BN > Na-h-BN > Na-G > Cl-G due to a combination of several interactions, including the distortion of the water network induced by the ions, the ion-water interaction, and the ion-nanopore interaction. Overall, the desalination performance of h-BN surpasses that of their graphene counterparts.

Surface acoustic wave (SAW) is effective for the manipulation of fluids and particles in microscale. The current approach of integrating interdigitated transducers (IDTs) for SAW generation into microfluidic channels involves complex and laborious microfabrication steps. These steps often require the full access to clean room facilities and hours to align the transducers to the precise location. This work presents an affordable and innovative method for fabricating SAW-based microfluidic devices without the need of clean room facilities and alignment. The IDTs and microfluidic channels are fabricated in the same process and thus precisely self-aligned in accordance with the device design. With the use of the developed fabrication approach, a few types of different SAW-based microfluidic devices have been fabricated and demonstrated for particle separation and active droplet generation.

Because Newton's gravitation and Einstein's general theory of relativity are macroscopic gravitational theories, lack of explanations for gravitation at the microscopic level. Therefore, this paper attempts to establish a set of micro-gravity theory, which is to explain the origin of Newtonian gravity and Einstein's general theory of relativity from the micro level. Based on the knowledge of Newton's gravitation and Einstein's general theory of relativity, the gravitational field is interpreted as a gradient field of space-time density; the Newtonian potential is interpreted as the density of an object at the micro level; gravity is interpreted as the potential pressure(space-time pressure) exhibited by the gradient of the density of the object at the micro level; flection space-time is interpreted as the presentation of the gradient distribution of density at the micro level. Based on the understanding of gravitation at the micro level, motion is interpreted as the embodiment of the change of space-time density. The motion of the object needs space-time density difference (potential difference) to maintain, thus a new equation of motion is obtained. Through this new equation of motion, It can explain the origin of inertia, the orbital motion of the stars, the rotation and the revolution.

Recent discoveries of potential ice particles and ice-cemented regolith on celestial bodies like the Moon and Mars have ushered in new opportunities for developing technologies to extract water, facilitating future space missions and activities on these celestial surfaces. This study delves into the potential for water extraction from regolith through an experiment designed to test water recuperation from regolith simulant under varying gravitational conditions. The resultant water vapor extracted from the regolith is re-condensed on a substrate surface and collected in liquid form. Three types of substrates, hydrophobic, hydrophilic, and grooved, are explored. The system’s functionality was assessed during a parabolic flight campaign simulating three distinct gravity levels: microgravity, lunar gravity, and Martian gravity. Our findings reveal that the hydrophobic surface demonstrates the highest efficiency due to drop-wise condensation, and lower gravity levels result in increased water condensation on the substrates. This experiment aims to provide insights into in-situ water recovery, which is pivotal for establishing economically-sustainable water supplies for future missions.

RNA transcripts play a crucial role as witnesses of gene expression health. Identifying disruptive short sequences in RNA transcription and regulation is essential for potentially treating diseases. Let’s delve into the mathematical intricacies of these sequences. We’ve previously devised a mathematical approach for defining a “healthy” sequence (10.14218/GE.2023.00079). This sequence is characterized by having at most four distinct nucleotides (denoted as nt≤4). It serves as the generator of a group denoted as fp. The desired properties of this sequence are as follows: fp should be close to a free group of rank nt−1, it must be aperiodic, fp should not have isolated singularities within its SL2(C) character variety (specifically within the corresponding Groebner basis). Now, let’s explore the concept of singularities. There are cubic surfaces associated with the character variety of a four-punctured sphere denoted as S24. When we encounter these singularities, we find ourselves dealing with some algebraic solutions of a dynamical second-order differential (and transcendental) equation known as the Painlevé VI equation (10.3390/dynamics4010001). In certain cases, S24 degenerates, in the sense that two punctures collapse, resulting in a “wild” dynamics governed by the Painlevé equations of an index lower than VI. In our paper, we provide examples of these fascinating mathematical structures within the context of miRNAs. Specifically, we find a clear relationship between decorated character varieties of Painlevé equations and the character variety calculated from the seed of oncomirs. These findings should find applications in cancer research.

The attitude dynamics and orbit dynamics of large rigid space structures are coupled with each other under gravity gradient, which may affect the stability of the large rigid space structures. In this paper, the gravity gradient stability of a large rigid space structure is studied under both small and large disturbances. Based on the rigid body dynamics and orbit dynamics, an accurate dynamic model without any linearization of the large rigid space structure is established via the natural coordinate formulation (NCF), which is able to describe the large overall motions of the structures. By using the generalized-α algorithm, the gravity gradient stability of the large rigid space structure is simulated and analyzed via various examples, including the influence of large disturbance angles, the positions at the stabilization and unstabilization regions. Finally, the relationship between spinning stability and gravity gradient stability is also investigated via a large spinning space structure.

The experiences gathered during the past 30 years support the operational use of irrigation scheduling based on frequent multi-spectral image data. Currently, the operational use of dense time series of multispectral imagery at high spatial resolution makes monitoring of crop biophysical parameters feasible, capturing crop water use across the growing season, with suitable temporal and spatial resolutions. These achievements, and the availability of accurate forecasting of meteorological data, allow for precise predictions of crop water requirements with unprecedented spatial resolution. This information is greatly appreciated by the end users, i.e. professional farmers or decision-makers, and can be provided in an easy-to-use manner and in near-real-time by using the improvements achieved in web-GIS methodologies. This paper reviews the most operational and explored methods based on optical remote sensing for the assessment of crop water requirements, identifying strengths and weaknesses and proposing alternatives to advance towards full operational application of this methodology. In addition, we provide a general overview of the tools which facilitates co-creation and collaboration with stakeholders, paying special attention to these approaches based on web-GIS tools.

Disk galaxies have a typical dimension of few tens of thousands of light years. It follows from the theory of general relativity that any signal originating from the galactic center will be noticed at the outskirts of the galaxy only tens of thousands of years later. This retardation effect is absent in modelling used to calculate rotation curves throughout the entire galaxy and its external gas. The considerable differences between Newtonian action at a distance predictions and observed velocities are currently removed either by assuming dark matter or by suggesting various modifications to the laws of gravity, MOND being a long standing alternative to Newtonian gravity. In previous papers we have shown that applying general relativity in a rigorous fashion without mindlessly neglecting retardation, one can explain the radial velocities of galactic matter without modifying gravity or adding unseen matter. Moreover, it was shown that dark matter effects as they appear in gravitational lensing, the Tully-Fisher relation, and mass estimations based on the virial theorem could also be explained as retarded-gravity effects. In the original main paper on the subject only one galaxy (M33) was analysed in detail. This was later amended somewhat with a published study of eleven galaxies. Here we give a more comprehensive retardation analysis of 143 galaxies of different types from the SPARC Galaxy collection. We show that in most cases we obtain an excellent fit without postulating dark matter or modifying general relativity.

Based on the need for real-time sag monitoring of Overhead Power Lines (OPL) for electricity transmission, this article presents the implementation of a hardware and software system for online monitoring of OPL cables and cable sag determination. The mathematical model based on differential equations and the methods of algorithmic calculation of OPL cable sag are presented. Considering that, based on the mathematical model presented, the calculation of OPL cable sag can be done in different ways depending on the sensors used, and the presented application uses a variety of sensors. Therefore, a direct calculation is made using one of the different methods. Subsequently, the verification relations are highlighted directly and, respectively, the calculation by the alternative method, which uses another group of sensors, to generate both a verification of the calculation and the functionality of the sensors, thus obtaining a defect observer of the sensors. The hardware architecture of the OPL cable online monitoring application is presented, together with the main characteristics of the sensors and communication equipment used. The configurations required to transmit data using the ModBUS and ZigBee protocols are also presented. The main software modules of the OPL cable condition monitoring application are described, which ensure the monitoring of the main parameters of the power line and the visualisation of the results both on the electricity provider's intranet using a web server and MySQL database, and on the Internet using an Internet of Things (IoT) server. This categorisation of the data visualisation mode is done in such a way as to ensure a high level of cyber security. Starting from the mathematical model of the OPL cable sag calculation, it goes through the stages of creating such a monitoring system, from the numerical simulations carried out using Matlab to the real-time implementation of this monitoring application. The main modules of the application software are: the software module for reading quantities from the sensor network through a ModBUS Input/Output (I/O) server, the software module for real-time calculation of the OPL cable sag, the software module for read/write operations based on MySQL type data, the software module for transferring data to the user's intranet through a web server, and the software module for viewing data by authorised users based on user and password through an IoT server. The development software environments used are Matlab and Laboratory Virtual Instrument Engineering Workbench (LabVIEW).

The ability to detect the presence as well as classify the activities of individuals behind visually obscuring structures is of significant benefit to police, security and emergency services in many situations. This paper presents the analysis from a series of experimental results generated using a through-the-wall (TTW) Frequency Modulated Continuous Wave (FMCW) C-Band radar system named Soprano. The objective of this analysis was to classify whether an individual was carrying an item in both hands or not using micro-Doppler information from a FMCW sensor. The radar was deployed at a standoff distance, of approximately 0.5 m, outside a residential building and used to detect multiple people walking within a room. Through the application of digital filtering, it was shown that significant suppression of the primary wall reflection is possible, significantly enhancing the target signal to clutter ratio. Singular Value Decomposition (SVD) signal processing techniques were then applied to the micro-Doppler signatures from different individuals. Features from the SVD information have been used to classify whether the person was carrying an item or walking free handed. Excellent performance of the classifier was achieved in this challenging scenario with accuracies up to 94%, suggesting that future through wall radar sensors may have the ability to reliably recognize many different types of activities in TTW scenarios using these techniques.

To establish simulated micro-gravity conditions, biological organisms are placed on a simulated microgravity system, which primarily rotate in two or three dimensions and rely on slow sedimentation with latency to detect gravity. Fluid dynamics arise as a consequence of rotation of the chambers with in which the cells are filled. To minimize the effects of centrifugal forces, it is necessary to position the samples as close to the center of rotation as possible. Strong shear forces and velocities within the vessel can have an adverse impact on cells, making this a critical topic in cell biology. During experimental investigation, this specific phenomenon is not apparent, but numerical modelling readily illustrates and is not widely analyzed in literature's. Furthermore, bulk flask are frequently employed on random positioning machines (RPM), not merely because they demand a substantial quantity of reagents. The flask presented in the study can be easily developed and fitted in conventional cell culture plates containing medium and reagents similar to those used in ground experiments, thus allowing it to remain close to the center of rotation. In the present study, a series of fluid dynamics simulations are performed to examine the impact of shear forces within the microvessel presented under varying conditions using a foreign medium condition, and these results are compared with existing vessels by observing the effects of shear forces and maximum velocity zones.

Ti and its alloys are the most commonly used materials for biomedical applications. However, bacterial infection after implant placement is still one of the significant rising complications. Therefore, the application of the antimicrobial agents into implant surfaces to prevent implant-associated infection has attracted lots of attention. Scientific papers have shown that inorganic antibacterial metal element (e.g. Ag, Cu, Zn) can be introduced to implant surfaces with the addition of metal nanoparticles or metallic compounds into electrolyte via micro-arc oxidation (MAO) technology. In this review, the effects of the composition and concentration of electrolyte and process parameters (e.g. voltage, current density, oxidation time) on morphological characteristics (e.g. surface morphology, bonding strength), antibacterial ability and biocompatibility of MAO antimicrobial coating were discussed in detail. Anti-infection and osseo-integration can be simultaneously accomplished with the selection of the proper antibacterial elements and operating parameters. Besides, MAO assisted by magnetron sputtering (MS) to endow Ti-based implant materials with superior antibacterial ability and biocompatibility was also discussed. Finally, the development trend of MAO technology in the future was forecasted.

Microscopic vision plays an important role in automated micro-assembly. However, some uncertain factors in the assembly process, such as occlusion and stains can lead to the mistakes of feature extraction. Herein, to solve the problem, the deep learning techniques are introduced into the feature recognition tasks, focusing on the attention mechanism and visualizing CNNs for DL-based microscopic vision. The main contributions are summarized as follows: The CBAM attention mechanism is combined with the YOLOv5 algorithm to improve the accuracy and robustness of feature extraction. The micropart feature occlusion experiment results show that at 70% occlusion degree, YOLOV5-CBAM can reach 97.9% [email protected], which is 4.6% higher than the original one. Visualization analysis of DL-based model is conducted using Grad-CAM to make the decision result more transparent and avoid potential visual detection risks during assembly. The heatmap matching degree between GT area and high-light area is increased by 27.81% on average, which further verify the effectiveness of attention mechanism in micropart feature localization. Additionally, micropart surface stain and droplet quality classification models based on ResNet50 are trained to replace the manual sorting. The visual results are consistent with human eye discernment and judgement, confirming the reliability of parts and droplets sorting.

Objectives: Social distancing measures are currently implemented to control COVID-19 pandemic in many countries, including Saudi Arabia. The aim of this study was therefore to evaluate the awareness and adherence of the Saudi population to these measures. Methods: A web-based questionnaire was designed with 16 questions (8 questions related to demographics, 3 in relation to awareness about social distancing and 5 related to overall practice of social distancing). Results: 5105 participants completed the survey [58.4% female, 66.3% young individuals (aged 18-37 years), 55.8% bachelor degree holders, and 51.0% from the western region]. The Saudi Ministry of Health (MOH) was the main source of information about COVID-19 for most participants (78.2%). High awareness (81.3%) regarding social distancing was observed, associated mainly with female participants, those from the middle region and those with high education and income. Overall implementation of social distancing was satisfactory (score 3.13/5), with 37.8% never leaving home during the home-stay period. Better adherence to social distancing was observed for female participants, higher degree holders and those aged over 38 years. Conclusions: Organised plans by the Saudi MOH have been effective in raising awareness and improving practice of social distancing among public. However, the observed lower practice of social distancing by individuals with lower education and income indicates the need for targeted interventions to achieve better outcome.

Benveniste’s experiments – known in the lay press as the “water memory” phenomenon – are generally considered to be a closed case. However, the amount of data generated by twenty years of well-conducted experiments prevents closing the file so simply. An issue, which has been little highlighted so far, merits to be emphasized. Indeed, if Benveniste failed to persuade his peers of the value of his experiments, it was mainly because of a stumbling block, namely the difficulty of convincingly proving the causal relationship between the supposed cause (“informed water”) and the experimental outcomes in different biological models. To progress in the understanding of this phenomenon, we abandon the idea of any role of water in these experiments (“water memory” and its avatars). In other words, we assume that “control” and “test” conditions to be evaluated were physically identical and differed only by their respective designations. We show in this article how simple probabilistic considerations allow to build a model that accounts for all aspects of Benveniste’s experiments. In this model based on probability amplitudes, constructive and destructive interferences emerge – or not – according to the experimental context. The recording of a statistical regularity shapes the intertwined whole constituted by the probability amplitudes of the states of the experimenter’s cognitive structures and of the experimental system. This model provides an alternative explanation to Benveniste’s experiments where water plays no role and where the place of the experimenter is central.

The human mind is multimodal. Yet most behavioral studies rely on century-old measures of behavior—task accuracy and latency (response time). Multimodal and multisensory analysis of human behavior creates a better understanding of how the mind works. The problem is that designing and implementing these experiments is technically complex and costly. This paper introduces versatile and economical means of developing multimodal-multisensory human experiments. We provide an experimental design framework that automatically integrates and synchronizes measures including electroencephalogram (EEG), galvanic skin response (GSR), eye-tracking, virtual reality (VR), body movement, mouse/cursor motion and response time. Unlike proprietary systems (e.g., iMotions), our system is free and open-source; it integrates PsychoPy, Unity and Lab Streaming Layer (LSL). The system embeds LSL inside PsychoPy/Unity for the synchronization of multiple sensory signals—gaze motion, electroencephalogram (EEG), galvanic skin response (GSR), mouse/cursor movement, and body motion—with low-cost consumer-grade devices in a simple behavioral task designed by PsychoPy and a virtual reality environment designed by Unity. This tutorial shows a step-by-step process by which a complex multimodal-multisensory experiment can be designed and implemented in a few hours. When conducting the experiment, all of the data synchronization and recoding of the data to disk will be done automatically.

In this paper, we present an experimental procedure to enhance the dimensional accuracy of fabrication via Stereolithography (SLA) of features at the micro-scale. Using a custom benchmark part, deviations in feature dimensions (micro-pores diameters and depths) were detected and measured by confocal microscopy. Samples characterization and experimental observations allowed the identification of inaccuracy sources, mainly due to the laser beam scanning strategy and to the incomplete removal of uncured liquid resin in post-processing (i.e., IPA washing). As a technology baseline, the measured dimensional errors on pores diameters were up to -46%. A compensation method of the nominal laser spot diameter (85m) was defined and implemented resulting in relevant improvements in dimensional accuracy of 9.8% and 11.3% on full-open pores diameter and depth, respectively. Further investigation was performed on a customized test part to adjust the calibration procedure. The measurements revealed that the estimate of the laser beam spot size is 968m. Measurements on micro-pores having different sizes revealed that a constant compensation parameter (i.e., C=85, 96, 120m) is not fully effective at the micro-scale, where average errors still remain at -24%, -18.8%, and -16% for compensations equals to 85, 96 and 120m, respectively. A further experimental campaign allowed the identification of an effective nonlinear compensation law where the compensation parameter depends on the micro-feature size C= f (D). Results show a sharp improvement in dimensional accuracy on micro-pore fabrication, with errors consistently below +8.2%. The proposed compensation method can be extended for the fabrication of any micro-features without restrictions on the specific technology implementation. Concerning the inaccuracy introduced by the laser path, experimentation with a customized part allowed the optimization of the part orientation to reduce the errors and their differences along the X and Y machine axes.

GaN ultraviolet photodetector with metal-semiconductor-metal structure is achieved by growing on a periodic trapezoid column-shape patterned sapphire substrate using metalorganic chemical vapor deposition. Under 5-V reverse bias, the photodetector fabricated on such patterned sapphire substrate exhibits a lower dark current, a higher photocurrent, and a 476 % enhancement in the maximum responsivity as compare with those of the photodetector fabricated on conventional flat sapphire substrate. It is also found that the much larger UV-to-visible rejection ratio and the fact that responsivity drops in a smaller cut-off region are observed from photodetector fabricated by using a periodic trapezoid column-shape patterned sapphire substrate. These phenomena may all be attributed to the reduction of threading dislocation density and the improved quality of GaN film, as well as the internal reflection and/or scattering effect on the interface between GaN film and the periodic trapezoid column-shape pattern of the substrate.

The conventional explanation of delayed-choice experiments seems to violate our causal intuition. This apparent violation is caused by a misinterpretation of the conventional formulation of quantum mechanics. I reanalyze these experiments using advanced and time-symmetric formulations of quantum mechanics. All three formulations give the same experimental predictions, but the advanced and time-symmetric formulations violate our causal intuition that effects only happen after causes. I explore reasons why our causal intuition may be wrong at the quantum level. I also suggest how conventional causation might be recovered in the classical limit, and speculate on cosmological boundary conditions.

The main purpose of this work was to tests of form and size of fatigue wear of the top layer of oil gear pump wheel (3PW-BPF-24). The object of tests was operated during a determined number of hours at strictly controlled operational and environmental parameters. A microscope of focal differentiation by Alicona InfiniteFocus G4 (with Focus-Variation optical measuring technology) was used for an identification, measurement and description of noticed superficial defects, which resulted from the fatigue process of the top layer and an earlier thermochemical treatment. The work was finished with an analysis of obtained results (based on the analysis of 3D scans) and conclusions concerning about optimization of the thermal treatment. Taking into consideration the presented results (suggestions) in the technology of improving strength properties of gear wheels (of this type oil pumps) may render it possible to obtain an appropriate fatigue endurance of the top layer, i.e. a minimization of observed superficial defects.

In a recent paper, we have shown how gravity and information can be related. The relation is based on the thermodynamic extension of the gravitational system under consideration using the holographic principle. Using this idea, we were able to derive the Gullstrand-Painlevé (GP) metric. In this short paper, we re-derive the GP metric using information. However, we now extend the spacetime to 5D with the fifth dimension being time, that is, the (3+1)D spacetime is now promoted to (3+1+1)D spacetime. We also comment on the possible Braneworld interpretation of this model.

Galaxies are rather big physical systems having a typical size of tens of kilo parsecs. Thus any change at the center of the galaxy will affect the outskirts only tens of thousand of years afterwards. Retardation seems to be neglected in current calculations of rotational velocities in the far edges of the galaxy and its surrounding gas. The differences between the velocities predicted by Newtonian theory and observational derivations are accommodated by either assuming "dark matter" or by introducing modifications to the laws of gravity in which MOdified Newtonian Dynamics (MOND) is one of the typical examples, celebrating now forty years since its inception. We show that there are overlapping conditions for retardation corrections in the weak approximation to general relativity and the low acceleration conditions for MOND corrections. We will also show that MOND interpolation formula is useful for calculating retardation effects provided an appropriate interpolation function is chosen.

This paper presents a quantitative approach to poetry, based on the use of several statistical measures (entropy, informational energy, N-gram, etc.) applied to a few characteristic English writings. We found that English language changes its entropy as time passes, and that entropy depends on the language used and on the author. In order to compare two similar texts, we were able to introduce a statistical method to asses the information entropy between two texts. We also introduced a method of computing the average information conveyed by a group of letters about the next letter in the text. We found a formula for computing the Shannon language entropy and we introduced the concept of N-gram informational energy of a poetry. We also constructed a neural network, which is able to generate Byron-type poetry and to analyze the information proximity to the genuine Byron poetry.

This paper gives both a general canonical quantum gravity theory and the general canonical quantum gravity theories of the Universe and general black hole, and discovers the relations reflecting symmetric properties of the standard nonlinear gravitational Lagrangian, which are not relevant to any concrete metric models. This paper concretely shows the general commutation relations of the general gravitational field operators and their zeroth, first, second and third style, respectively, of high order canonical momentum operators for the general nonlinear system of the standard gravitational Lagrangian, and then has finished all the four styles of the canonical quantization of the standard gravity.

The objective of the study was to analyse the antimicrobial susceptibility trends of Spanish porcine bacteria to quinolones, cephalosporins and polymyxins. Isolates of Actinobacillus pleuropneumoniae, Pasteurella multocida, and Escherichia coli were isolated from sick pigs from 2019 to 2022. Antimicrobial susceptibility test was determined by minimal inhibitory concentration (MIC) following internationally accepted methodology. MIC categorization was based on distributing the range of MIC values in four categories being category one the most susceptible (lowest MIC value) and four the less susceptible one (highest MIC value). Moreover, clinical susceptibility (susceptible/resistant) was also determined according to CLSI and EUCAST clinical breakpoints. A logistic and multinomial logistic regression model was used to analyze the susceptibility data for dichotomized and categorized MIC data, respectively for any pair of antimicrobial/microorganism. In general terms, the antimicrobial susceptibility of pig bacteria to these antimicrobials remained stable or increased in the last four years in Spain. In the case of A. pleuropneumoniae and quinolones, it was observed a significant temporal trend where isolates from 2020 had significantly increased odds of being more susceptible than isolates from 2019. In the case of E. coli and polymyxins, a significant temporal trend was observed where isolates from 2020 and 2021 had significantly increased odds of being more susceptible than isolates from 2019 and 2020, respectively. Finally, a significant odd of being less susceptible was only observed for cephalosporins and E. coli for 2020 versus 2019, stagnating for the rest of study period. These results provide sound data on critical important antimicrobials in swine medicine.

This study reports on the development of bio-based hydrophobic coatings for packaging papers through deposition of polyhydroxybutyrate (PHB) particles in combination with nanofibrillated cellulose (NFC) and plant wax. In a first approach, PHB particles in micrometer range (PHB-MP) were prepared through a phase-separation technique providing internally nanosized structures. The particles were transferred as a coating by dip-coating filter papers in the particle suspension, followed by sizing with a carnauba wax solution. This approach allowed partial to almost full surface coverage of PHB-MP over the paper surface resulting in static water contact angles of 105° to 122° and 129° to 144° after additional wax coating. In a second approach, PHB particles with submicron sizes (PHB-SP) were synthesized by an oil-in-emulsion (o/w) solvent evaporation method, and mixed in aqueous suspensions with 0 to 7 wt% NFC. After dip-coating filter papers in PHB-SP/NFC suspensions and sizing with a carnauba wax solution, static water contact angles of 112° to 152° were obtained. The intrinsic properties of the particles were analyzed by scanning electron microscopy, thermal analysis and infrared spectroscopy, indicating higher crystallinity for PHB-SP than PHB-MP. The chemical interactions between the more amorphous PHB-MP particles and paper fibers were identified as an esterification reaction, while the morphology of the NFC fibrillar network was playing a key role as binding agent in the retention of more crystalline PHB-SP at the paper surface, hence contributing to higher hydrophobicity.

Using pumps operating as turbines (PATs) offers the possibility of increasing the sustainability of water and energy systems by recovering the excess of energy that would be otherwise lost in pressure reducing valves or head loss chambers. In on-grid applications, there are many research works and implementations of PATs. However, there is still limited research for the optimization of efficiency and stability of PATs operating in off-grid systems. This work contributes to the development of stable direct current (DC) off-grid electric systems based on PATs, by optimizing and analysing the energy efficiency and stability for a wide range of operation. A self-excited induction generator (SEIG) coupled to the PAT is provided to cover the conventional type of electric ma-chines typically coupled to the hydraulic pumps. In this context, a methodology is proposed, based on the hydraulic, mechanical and electric subsystems, to define the PAT-SEIG operational area, to maximize energy conversion and the system efficiency. This will guarantee stable electric output quantities when operating in a DC off-grid system. In addition, an analytical model is proposed to estimate the PAT-SEIG operation under specific conditions. With this, water managers are suitable to design and optimize an off-grid PAT-SEIG system and to define the best hydraulic machines, electronic equipment, and all different control elements to maximize energy conversion within the target of operational limits. To develop and verify this new methodology, two micro PAT-SEIG setups were implemented in the hydraulic laboratory of IST/CERIS under typical operating conditions. The proposed solution proved to be resilient under a variable load regime. The system's maximum efficiency can be adapted using different capacitor values for the excitation of the SEIG, and the operational range is limited to the electric components. Considering the nominal efficiencies of the system’s components, the maximum p.u. efficiency obtained for each PAT-SEIG system were between 0.7 and 0.8 p.u.

Cirina forda caterpillars are a significant protein source in Central Africa, yet their preservation and consumption pose challenges. This study investigates the drying of Cirina forda caterpillars to enhance preservation methods and product quality. Caterpillars were subjected to drying experiments at temperatures ranging from 40°C to 70°C, using tunnel and oven dryers. The drying kinetics was analyzed using mathematical models, revealing a water diffusion-limited mechanism in all the tested conditions. The Newton model provided adequate estimations of the drying behavior, facilitating further practical dryer design. Shrinkage analysis indicated a two-step process independent of the drying conditions. Achieving a moisture content suitable for prolonged storage resulted in substantial volume loss, highlighting the challenges of preserving dried caterpillars. These findings shed light on how to optimize drying processes for Cirina forda caterpillars, crucial for sustaining protein sources in Central Africa.

Scientists are gradually becoming aware of the challenges in the understanding of the very root mechanisms of massively parallel computations that are observed in literally all scientific disciplines ranging from cosmology, physics, across chemistry, biochemistry, and ending in biology. This leads us to the main motivation and simultaneously to the central thesis of this review: “Can we design artificial, massively-parallel, self-organized, emergent, error-resilient, computational environments?” A large number of simulations along with examples and counter-examples, finalized by a list of the future directions, are giving hints and partial answers to the main thesis. This all together is opening the crucial question whether there is existing a deeper, beyond the Turing machine theoretical description of massively-parallel computing. Important information dealing with this topic is reviewed along with highly expressive animations generated by the open-source, Python software GoL-N24. The perspective, future directions including applications in robotics and biology of this research are discussed in the light of known information.

Theoretical physics addresses the fundamental principles of nature and the mysteries of the universe. In the last century, the theory of relativity challenged people's understanding of time and space, while quantum mechanics revealed various forms of energy. However, the concept of gravity remains elusive. All matter in the universe is composed of energy that can be converted into other forms, yet it is always conserved. However, achieving a state of equilibrium, represented by the equal sign, can be challenging to achieve on both macro and quantum scales. A phenomenon that can transition from one state to infinity is called collision and is essential for understanding natural phenomena and physical processes throughout the universe. In the study of general relativity cannot be three-dimensional problems to gain mathematical inspiration, understand the application of new dimensions. Here, we elucidate the nature of gravity, which inspires the solution of the Riemann hypothesis. Our results show that the conduction mode of dimensional energy is defined by Euler's formula.

The holographic principle states that the information about the volume of space is stored on its boundary. Assuming this holds, we can explain the aspects of gravity. The spacetime needs to be extended to 5D to explain gravity in this context. This naturally explains the four classical tests of gravity namely the gravitational redshift, the perihelion precession, the bending of light, and the gravitational time delay. We also show a novel way in which the universe expands in an accelerated manner at late times without the need for any form of dark energy.

At present there is a renewed interest in theories of ”modified” gravity. Here, under a more drastic modification enforced by Galilei group, we obtain a completely new gravitational structure, and which exists in addition to the already available general relativity of today. Correlated with this, we show that in addition, there is a new ”modified” quantum mechanics, in as much as it exists as an independent and new ”pure” non-relativistic quantum me- chanics, and which has no relativistic counterpart. This is in addition to the present quantum mechanics, where the relativistic and non-relativistic structures are counterparts of each other. The above holds, firstly due to the correlation between Galilei group and quantum mechanics. These math- ematical conclusions are consolidated by the fact that there exists a physical Majorana interaction between each neutron- proton pairs in nuclei. Galilei invariance of Majorana exchange in Majorana interaction, shows that the mass here is of pure gravitational nature, and which is immune to the other three forces. This makes an amazing connection between the gravitational force and the quantum mechanics. This pure gravitational mass would man- ifest itself as dark matter of the universe. It is our new modified gravity that generates the dark matter.

: Microplastics and nanoplastics (MNPs) are becoming an increasingly severe global problem due to their widespread distribution and complex impact on living organisms. Apart from their environmental impact, the effects of MNPs on living organisms have also continued to attract attention. The harmful impact of MNPs has been extensively documented in marine invertebrates and larger marine vertebrates like fish. However, the research on the toxicity of these particles on mammals is still limited, and their possible effects on humans are poorly understood. Considering that MNPs are commonly found in food or food packaging, humans are primarily exposed to them through ingestion. It would be valuable to investigate the potential harmful effects of these particles on gut health. This review focuses on recent research exploring the toxicological impacts of micro- and nanoplastics on the gut, as observed in human cell lines and mammalian models. Available data from various studies indicate that the accumulation of MNPs in mammalian models and human cells may result in adverse consequences, in terms of epithelial toxicity, immune toxicity, and disruption of gut microbiota. The paper also discusses the current research limitations and prospects in this field, aiming to provide a scientific basis and reference for further studies on the toxic mechanisms of micro- and nanoplastics.

The thesis proposes a argument that a mass point moving in a horizontal circle on the Earth's surface can generate a radial centrifugal force of the Earth's center of mass, thus realizing an unconventional anti-gravity path. And through the theoretical analysis of the difference in the distribution of gravitational acceleration at different latitudes caused by the rotation of the earth, and the centrifugal force of a mass point moving in a horizontal circle on the earth's surface is analyzed, the validity of the argument is demonstrated. At the same time, the paper puts forward two possible basic principles, and makes theoretical analysis and demonstration. Conceive of the concrete experimental verification of principle two is proposed. Four technical schemes for antigravity ascent are proposed and basic analysis is made. On the premise of not fully considering the practical technical ability, it is theoretically proved that three of them have realistic operability and development potential. In theory, this paper opens up a different way of anti-gravity for human beings, which will bring new ideas and prospects for human beings to get rid of the bondage of gravity.

“Non-Locality is most naturally incorporated into a theory in which there is a special frame of reference. One possible candidate for this special frame of reference is the one in which the Cosmic Microwave Background (CMB) is isotropic. However, other than the fact that a realistic interpretation of quantum mechanics requires a preferred frame and the CMB provides us with one, there is no readily apparent reason why the two should be linked” (L. Hardy). Starting from this remark we first argue that, given the present view of the vacuum, the basic tenets of Quantum Field Theory cannot guarantee that Einstein Special Relativity, with no preferred frame, is the physically realized version of relativity. Then, to try to understand the nature of the hypothetical preferred Σ−frame, we consider the so called ether-drift experiments, those precise optical measurements that try to detect in laboratory a small angular dependence of the two-way velocity of light and then to correlate this angular dependence with the direct CMB observations with satellites in space. By considering all experiments performed so far, from Michelson-Morley to the present experiments with optical resonators, and analyzing the small observed residuals in a modern theoretical framework, the long sought Σ− frame tight to the CMB naturally emerges. Finally, if quantum non-locality reflects some effect propagating at vastly superluminal speed vQI→∞, its ultimate origin could be hidden somewhere in the infinite speed cs→∞ of vacuum density fluctuations.

The classical Einstein’s Field Equation has been derived previously by demanding that the Clausius relation dS = δQ/T holds. In this letter, we show that the semiclassical Einstein’s Field Equation can be recovered using the generalized entropy Sgen by using the non-equilibrium thermodynamics where the Clausius relation is replaced by the entropy balance relation dS = δQ/T +diS, where diS is some internal entropy. Moreover, since the quantum fields violate the classical focusing, we, therefore, have to use quantum focusing in this case. Using then Jacobson’s idea of thermodynamics of spacetime we recover the semiclassical equation of motion. We, therefore, in a sense also show the validity of the semiclassical approximation, a crucial approach for establishing a number of important ideas such as the Hawking effect.

The extremely high rotation of some SMBHs is the origin of their relativistic rotational energy that results in their relativistic mass. Relativistic mass creates their relativistic gravity which is a partial answer to the missing dark matter.

Some physicists surmise that gravity lies outside of quantum mechanics. Thus theories like the standard semiclassical theory of quantum to gravity coupling (that of Rosenfeld and Møller) are possible real models of interaction, rather than a mere approximation of a theory of quantum gravity. Unfortunately, semiclassical gravity creates inconsistencies such as superluminal communication. Alternatives by authors such as Diósi, Martin, Penrose, and Wang often use the term 'stochastic' to set themselves apart from the standard semiclassical theory. These theories couple to fluctuations caused by for instance continuous spontaneous localization, hence the term 'stochastic'. This paper looks at stochastic gravity in the framework of a class of emergent or ontological quantum theories, such as those by Bohm, Cetto, and de Broglie. It is found that much or all of the trouble in connecting gravity with a microscopic system falls away, as Einstein's general relativity is free to react directly with the microscopic beables. The resulting continuous gravitational wave radiation by atomic and nuclear systems does not, in contrast to Einstein's speculation, cause catastrophic problems. The small amount of energy exchanged by gravitational waves may have measurable experimental consequences. A very recent experiment by Vinante et al. performed on a small cantilever at mK temperatures shows a surprising non-thermal noise component, the magnitude of which is consistent with the stochastic gravity coupling explored here.

Micro-combs [1-4] - optical frequency combs generated by integrated micro-cavity resonators – offer the full potential of their bulk counterparts [5,6], but in an integrated footprint. The discovery of temporal soliton states (DKS – dissipative Kerr solitons) [4,7-11] as a means of mode-locking micro-combs has enabled breakthroughs in many fields including spectroscopy [12,13], microwave photonics [14], frequency synthesis [15], optical ranging [16,17], quantum sources [18,19], metrology [20,21] and more. One of their most promising applications has been optical fibre communications where they have enabled massively parallel ultrahigh capacity multiplexed data transmission [22,23]. Here, by using a new and powerful class of micro-comb called “soliton crystals” [11], we achieve unprecedented data transmission over standard optical fibre using a single integrated chip source. We demonstrate a line rate of 44.2 Terabits per second (Tb/s) using the telecommunications C-band at 1550nm with a spectral efficiency – a critically important performance metric - of 10.4 bits/s/Hz. Soliton crystals exhibit robust and stable generation and operation as well as a high intrinsic efficiency that, together with a low soliton micro-comb spacing of 48.9 GHz enable the use of a very high coherent data modulation format of 64 QAM (quadrature amplitude modulated). We demonstrate error free transmission over 75 km of standard optical fibre in the laboratory as well as in a field trial over an installed metropolitan optical fibre network. These experiments were greatly aided by the ability of the soliton crystals to operate without stabilization or feedback control. This work demonstrates the capability of optical soliton crystal micro-combs to perform in demanding and practical optical communications networks.

Due to their wide range of uses in modern technology, nanomaterial’s of silver metallic (Ag-NPs) have engaged considerable concern, driving significant research with development efforts. This study focuses on investigating the antimicrobial properties of Ag-NPs, encompassing their production, characterization, and biological aspects. The eco-friendly extracellular biosynthetic method employed in this work utilized extracts from the marine fungus Aspergillus flavus MK4 as reducing agents for nanoparticle synthesis. Analyzing the colloidal Ag-NPs using UV-visible spectroscopy revealed a peak in absorbance at 460 nm, indicating the presence of plasmonic properties. The electrons imaging of internal structure (TEM) elucidated spherical shape of the Ag-NPs by 15 nm size. Testing against bacterial diversities (Gr-ve & Gr+ve) revealed potent antibacterial and antifungal efficacy. Cytotoxicity versus HepG-2 cell line was assessed using the MTT assay, and antioxidant properties were examined through the radical scavenging (DPPH) assay. In wise of their conceivable applications in the fields of antibacterial, anticancer, and wound-healing, the Ag-NPs that were synthesized exhibit promising features. With its powerful ability to synthesize silver nanoparticles (Ag-NP), Aspergillus flavus MK4 Aspergillus flavus MK4 can generate nanoparticles extensively characterized, demonstrating their antibacterial, antioxidant, anticancer, and wound-healing properties.

(3+1)D quantum mechanics is a four-dimensional quantum formalism, which is developed neither in a Minkowski spacetime, nor in a purely Hilbert space and not its metric is Lorentzian. This quantum mechanics also yields the quantum Einstein field equation in (3+1)D quantum spacetime. Every observable (3+1)D quantum spacetime can be found to contain internally hidden opposite spin quantum state, that results Supersymmetry. Closed continuous mappings of this hidden quantum state immediately yield more extra hidden dimensions including string. This string is found to be fundamentally eleven-dimensional (rather than lower dimensional) by nature within this quantum spacetime, which is necessarily a natural phenomenon of (3+1)D Quantum Mechanics.

We analyze different approaches to quantum gravity. It is stressed that nonperturbative methods to quantise gravity and the usage of diffeomorphism-invariant variables are very important. We pay attention on the Wheeler--DeWitt equation in the framework of canonical quantum gravity. The Wheeler--DeWitt equation is presented in the first order formalism with the hope that this form can solve some problems such as singularities and the ordering. Also, there is a problem of defining the time.

In order to study the adsorption process and adsorption characteristics of shale oil at the macro scale, the isothermal adsorption experiments of illite and kerogen on heptadecane (oil phase) solution were carried out by infrared spectrophotometry and gas chromatography-mass spectrometry. The reaction mechanism of alkane solution concentration and temperature in the adsorption process was investigated. The adsorption characteristics of heptadecane on the surface and pores of illite and kerogen were elucidated by adsorption isotherm model and adsorption thermodynamic model. The results show that: The concentration of alkane solution contributes to the adsorption of illite and kerogen. As the concentration of the solution continues to increase, the adsorption rate gradually slows down. However, the temperature hardly affects the adsorption rate. At 25℃, 50℃ and 60℃, the adsorption process of illite on alkane solution is more consistent with Langmuir model and Freundlich model, respectively. The difference is that Langmuir model is suitable for describing the whole adsorption process of kerogen on alkane solution. 3) The adsorption process of illite and kerogen to heptadecane solution is an endothermic reaction. Heating helps to accelerate the migration rate of alkanes, which is conducive to the adsorption reaction. The research results clarify the adsorption characteristics of shale oil heavy components from the macro level, and fill the research gap in the application of solid-liquid isothermal adsorption physical experiments to the adsorption and occurrence of shale oil.

We report on the design and construction of a spin-flip Zeeman slower, quadrupole magnetic trap, and Feshbach fields for a new machine for ultra-cold Li-7. The small mass of the Li-7 atom, and the tight lattice spacing, will enable us to achieve a 100-fold increase in tuneling rates over comparable Rb-87 optical lattice emulator experiments. These improvements should enable to access new regimes in quantum magnetic phase transitions and spin dynamics.

Microorganisms drive the biogeochemical cycles that link abiotic and biotic processes in the aqueous environment and are intricately associated with plastic debris. The detection of microplastics in water and sediment introduces new concerns as small particle size allows for yet unconsidered pathways for plastics in the food web and element cycles. In this review, we present current knowledge of microbe-plastic interactions and summarize the potential impact of biogeochemical processes on plastic distribution, cycling, transport, and sedimentation. We explore how microbe-plastic interactions influence the exposure of consumers to plastics and plastic degradation products. Key methods used to elucidate biofilm development, microbial biodegradation, and plastic detection in the aqueous environment are discussed. Finally, we comment on potential future questions and research directions needed to further define the role of microorganisms in the environmental fate of microplastics.

In this work the close relation between vorticity and micro-rotation in micropolar flows in Rn (n = 2 or 3) is identified and used to explain the faster decay by t^(-1/2) of the angular velocity of the micro-rotation of fluid particles, as well as establishing its optimality. For this purpose important upper and lower bounds for Leray solutions in homogeneous Sobolev spaces are derived, using the monotonicity approach recently introduced by the authors for dissipative systems in general. Several related results of interest are also given along the discussion.

When participants in a statistical learning paradigm are asked to learn from two incompatible or competing inputs, they often fail to learn from one or both inputs. This study presents the results of two experiments that were both completed by one group of typically developing four-year-old children. One experiment targeted word-medial consonant patterns (phonotactics), whereas the other targeted strong-weak and weak-strong stress patterns (prosody). The order of the experiments was critical for learning outcomes in the phonotactics experiment: When children learned phonotactics first, their production accuracy increased following exposure to a high frequency input. When children learned phonotactics second, however, their production accuracy dropped when they were exposed to the high frequency input. Results from the prosody experiment were inconclusive, with limited evidence of any learning effect. Overall, the results suggest that children may conflate learning experiences, and patterns learned from an initial experimental input compete with patterns in a subsequent experiment. When considering natural language acquisition, the results suggest that an isolated episode of learning may lead to generalizations that are incompatible with later input, and possibly, with larger patterns in the language.

Sustainable agriculture is essential to provide food security for a growing world population without further sacrificing the integrity of the environment. To make progress towards agricultural sustainability we must consider ecological and socioeconomic processes within the agricultural socio-ecosystem and involve stakeholders in the research process. We propose an innovative experimental approach for examining how natural regulation of ecosystems may provide an alternative to increasing external inputs in agriculture while improving the socio-economic welfare of farmers. These “social-ecological experiments” go further to participatory action research by not only involving stakeholders in the research process but also by manipulating simultaneously socioeconomic and ecological processes under real field conditions to give a faster route to sustainability. Social-ecological experiments are undertaken in real field conditions, explicitly involving stakeholders, and help untangle the drivers of social-ecological dynamics under various land management and farming practices. Social-ecological experiments are distinct from adaptive management and scenario-planning approaches as they highlight the interactions between ecological and social processes, manipulate the social and ecological processes shaping the system and show causal links between patterns and processes. As an example, we describe a social-ecological experiment for reducing herbicide use. Social-ecological experiments offer great opportunities for increasing stakeholders’ acceptance of environmental policies implemented through adaptive management. These experiments may help to identify management practices that optimize multiple objectives, deliver a portfolio of ecosystem services and satisfy key stakeholders.

A viable radiation dominated era in the early universe is best described by the standard (FLRW) model of cosmology. In this short review, we demonstrate reconstruction of the forms of F(R) in the modified theory of gravity, and the metric compatible F(T) together with the symmetric F(Q) in alternative teleparallel theories of gravity from different perspectives, primarily rendering emphasis on a viable FLRW radiation era. Inflation has also been studied for a particular choice of the scalar potential. The inflationary parameters are found to agree appreciably with the recently released observational data.

The correspondence principle made of unitarity, locality and renormalizability has been very successful in quantum field theory. Among the other things, it helped us build the standard model. However, it also showed important limitations. For example, it failed to restrict the gauge group and the matter sector in a powerful way. After discussing its effectiveness, we upgrade it to make room for quantum gravity. The unitarity assumption is better understood, since it allows for the presence of physical particles as well as fake particles (fakeons). The locality assumption is applied to an interim classical action, since the true classical action is nonlocal and emerges from the quantization and a later process of classicization. The renormalizability assumption is refined to single out the special role of the gauge couplings. We show that the upgraded principle leads to an essentially unique theory of quantum gravity. In particular, in four dimensions, a fakeon of spin 2, together with a scalar field, is able to make the theory renormalizable while preserving unitarity. We offer an overview of quantum field theories of particles and fakeons in various dimensions, with and without gravity.

In this paper we will show that standard physics to a large degree consists of derivatives of a deeper reality. This means standard physics is both overly complex and also incomplete. Modern physics has typically started from working with first understanding the surface of the world, that is typically the macroscopic world, and then forming theories about the atomic and subatomic world. And we did not have much of a choice, as the subatomic world is very hard to observe directly, if not impossible to observe directly at the deepest level. Despite the enormous success of modern physics, it is therefore no big surprise that we at some point have possibly taken a step in the wrong direction. We will claim that one such step came when one thought that the de Broglie wavelength represented a real matter wavelength. We will claim that the Compton wavelength is the real matter wavelength. Based on such a view we will see that many equations in modern physics are only derivatives of much simpler relations. Second, we will claim that in today’s physics one uses two different mass definitions, one mass definition that is complete or at least more complete, embedded in gravity equations without being aware of it, as it is concealed in GM, and the standard, but incomplete, kg mass definition in non-gravitational physics. First, when this is understood, and one uses the more complete mass definition that is embedded in gravity physics, not only in gravity physics, but in all of physics, then one has a chance to unify gravity and quantum mechanics. Our new theory shows that most physical phenomena when observed over a very short timescale are probabilistic for masses smaller than a Planck mass and dominated by determinism at or above Planck mass size. Our findings have many implications. For example, we show that the Heisenberg uncertainty principle is rooted in a foundation not valid for rest-mass particles, so the Heisenberg uncertainty principle can say nothing about rest-masses. When re-formulated based on a foundation compatible with a new momentum that is also compatible with rest-masses, we obtain a re-defined Heisenberg principle that seems to become a certainty principle in the special case of a Planck mass particle. Furthermore, we show that the Planck mass particle is linked to gravity and that we can easily detect the Planck scale from gravity observations. The Planck mass particle is unique as it only lasts the Planck time, and in that very short time period it can only be observed directly from itself, and it therefore closely linked to absolute rest.

A new model of gravity is presented here similar to the earlier work of Verlinde on Emergent Gravity but without the use of Verlinde's main assumption on the nature of gravity as an entropic force using the First Law of Thermodynamics. Instead, the model will be shown to be consistent with the Second Law of Thermodynamics as used in Black Hole Physics. Moreover, it does not use the Equipartition Theorem such that there is no need to define a thermal bath enclosed within a holographic screen. The theory uses $E=NE_{p}$, for the total energy of a massive object where $E_{p}$ is the Planck Energy while $N$ is the number of Planck Energy to represent the maximum possible density of information that can reside in matter. The theory uses also the Holographic Principle as the basis for an information-theoretic approach to the nature of gravity. It is shown here that gravity emerges whenever there is an updating of the information within a given volume of space by the presence of matter.

The recently proposed and logically developed paradigm of deep genetical affinity of scientific terms "energy-entropy-information" harmonizes classical and quantum physics with general and special theories of relativity. For the first time in engineering practice, a complex vector-tensor-matrix description of gravitational, thermal and electromagnetic fields in ideal solid, liquid and gaseous media was performed analytically and without preliminary measurements. The basic set of fundamental quantum constants of the standard physical model has been computed with an extreme precision of 1/10^64, which is a natural limit arising due to elementary recursive arithmetic and elementary functional analysis in digital notation.

It is shown that Verlinde’s hypothetical concepts of entropic gravity can be successfully applied to the author’s previous work on the modification of the Newtonian gravity by Einstein’s Cosmological Constant. It allows a theoretical justification for Milgrom’s empirical acceleration constant, thereby revealing some fundamental differences with Verlinde’s conclusions.

We study a localization of gravity through the matching point between non-inertial frames and local inertial frames. This localization of gravity is done through defining relative gravitational red-shift. This lead to an emergence of a timeless state in a mathematically consistent way. In this timeless state of gravity, we find a geometric interpretation of the speed of light and mass. The experimental support of the timeless state is the quantum entanglement and internal symmetries that are independent of time. Therefore gravity would be responsible for measurements independent of time including quantum entanglement. Timeless state in that sense explain why do we have gravity/gauge correspondence. We conjecture that the universe emerged from a black hole with a global $SU(3)\times SU(2)\times U(1)$ symmetry on its event horizon that produces gauge fields Electromagnetism, weak and strong nuclear force through localization of this global symmetry. Through the localization in the gravity field, the timeless measurements such as spin will be correlated with the varying of timeless measurement which is relative gravitational red-shift. We present a gravitational or geometric interpretation of spin-0, spin-1, and spin-1/2 states. We present an interpretation of why do we measure matter rather than anti-matter. We found that the Higgs scalar field is represented by the gravitational red-shift at every point in the space around the black hole. We derive the numerical value of the cosmological constant that agrees with experimental observations.

Decomposition of natural and synthetic polymeric materials (peat, humates, biochar, strongly swelling hydrogels and other soil conditioners) in a biologically- and chemically- active soil environment inevitably leads to their degradation and ability to improve the structure, water-retention, absorptive capacity and actual fertility of artificial soil constructions in urbanized ecosystems and agro landscapes (constructozems). Quantitative assessment of the biodegradation process using field and laboratory incubation experiments, as well as mathematical modeling, showed the possibility of significant (up to 30-50% per year) losses of organic matter of constructozems and a corresponding deterioration in their quality. Incubation experiments with the analysis of carbon dioxide emission for polymeric materials under given thermodynamic conditions allow to estimate the potential rates of their decomposition (half-life) and their dependence on the dose of inhibitors of microbial activity. Special nomographs provide an opportunity to determine the optimum depth of the arrangement of organic components in soil constructions to ensure their stable functioning during a fixed operating time in urban conditions. The results of the study are useful for geo-engineers and landscaping practitioners.

Purification of biologically-derived therapeutics is a major cost contributor to the production of this rapidly growing class of pharmaceuticals. Monoclonal antibodies comprise a large percentage of these products therefore new antibody purification tools are needed. Small peptides, as opposed to traditional antibody affinity ligands such as Protein A, may have advantages in stability and production costs. Multiple heptapeptides that demonstrate Fc binding behavior that have been identified from a combinatorial peptide library using M13 Phage Display are presented herein. Seven unique peptide sequences of diverse hydrophobicity and charge were identified. All seven peptides showed strong binding to the four major human IgG isotypes, human IgM, as well as binding to canine, rat, and mouse IgG. These seven peptides were also shown to bind human IgG4 from DMEM cell culture media with 5% FCS and 5 g/L ovalbumin present. These peptides may be useful as surface ligands for antibody detection and purification purposes. Molecular docking and classical molecular dynamics (MD) simulations were conducted to elucidate the mechanisms and energetics for the binding of these peptides to the Fc region. The binding site was found to be located between the two glycan chains inside the Fc fragment. Both hydrogen bonding and hydrophobic interactions were found to be crucial for the binding interactions. Excellent agreement for the binding strength was obtained between experimental results and simulations.

It was recently shown that urban networks might exhibit two different critical points, one for the percolation of congested links through the network, and another one for the flow of vehicles through the network. It was observed that the percolation critical point happens after the flow critical point, where network throughput is maximized. This result is important because if a causal relationship exists between these two processes, it can be leveraged for improving control methods to avoid network collapse. This paper presents the results of numerical experiments to understand the possible causal relationship between the percolation and flow processes by focusing on the relative timing between the two critical points. The goal is to understand the impacts of important factors such as: (i) urban network type: long- and short-block networks, (ii) signal timing control type: fixed, random, responsive, and (iii) route choice: turning proportions at intersections. We find that the threshold density $k^*_c$ to determine if a link is congested has the main impact on the timing of the percolation transition, where lower values trigger earlier transitions. This implies that $k^*_c$ can be set such that the percolation transition happens before the flow critical point, opening the door for improved congestion management strategies. If $k^*_c$ is set to the average network critical density, maximum network throughput happen simultaneously with the percolation transition. Surprisingly, it appears that these results, and more generally, the relationship between the percolation and flow processes is independent of (i) and (ii) above.

The bottleneck in creating dynamic models of biological networks and processes often lies in estimating unknown kinetic model parameters from experimental data. In this regard, experimental conditions have a strong influence on parameter identifiability and should therefore be optimized to give the maximum information for parameter estimation. Existing model-based design of experiment (MBDOE) methods commonly rely on the Fisher Information Matrix (FIM) for defining a metric of data informativeness. When the model behavior is highly nonlinear, FIM-based criteria may lead to suboptimal designs since the FIM only accounts for the linear variation of the model outputs with respect to the parameters. In this work, we developed a multi-objective optimization (MOO) MBDOE, where model nonlinearity was taken into consideration through the use of curvature. The proposed MOO MBDOE involved maximizing data informativeness using a FIM-based metric and at the same time minimizing the model curvature. We demonstrated the advantages of the MOO MBDOE over existing FIM-based and other curvature-based MBDOEs in an application to the kinetic modeling of fed-batch fermentation of Baker's yeast.

Forty-eight Pasteurella multocida isolates were recovered from porcine pneumonic lungs collected in Norwestern Spain (2017- 2019). These isolates were characterized for their minimal inhibition concentrations to twelve antimicrobial agents and for the appearance of eight resistance genes: tetA, tetB, blaROB1, blaTEM, ermA, ermC, mphE and msrE. Relevant resistance percentages were shown to teracyclines, sulphamethoxazole/trimethoprim and tiamulin, thus suggesting that P. multocida isolates were mostly susceptible to amoxicillin, ceftiofur, enrofloxacin, florfenicol, marbofloxacin and macrolides. 29.2% of isolates were resistant to more than two antimicrobials. The tetracycline resistance genes (tetA and tetB) were detected in 22.9% of the isolates, but none was positive to both simultaneously; blaROB1 and blaTEM genes were found in one third of isolates but both genes were detected simultaneously in only one isolate. ermC gene was observed in 41.7% of isolates, a percentage that decreased until 22.9% for msrE; finally, ermA was harboured by 16.7% and mphE was not found in any of them. Six clusters were established based on hierarchical clustering analysis on antimicrobial susceptibility for the twelve antimicrobials. Generally, it was unable to foresee the antimicrobial susceptibility pattern for each family and the association of each particular isolate inside the clusters established from the presence or absence of the resistance genes analyzed.

Energy transition is one of the greatest challenges facing humanity today. All micro, small, medium and large enterprises in operation will have to face it, and some can al-ready boast the first successes in this regard. This paper focuses on the involvement of these smallest players in energy transition. Micro and small entities are the largest part of the economy, having a great influence on its development. Looking at the wide scale of their activities, these entities are distinguished by a specific owner-manager relationship. This means that the final decision-making is influenced by business goals, but also by the manager's approach, their awareness of changes, and personal and other factors. Based on a structured and standardized survey questionnaire, the research was carried out using the Computer-Assisted Telephone Interviewing technique between April and May 2022 among owners of micro and small enterprises operating in Poland. The survey showed that active engagement of micro and small enterprises in energy efficiency initiatives is related to their market success and financial health.

This study presents the B92 Quantum Key Distribution scheme and its optimization and implementation considerations. Simulation software was developed to model and analyze the B92 protocol under varying conditions. Another contribution of this work is investigating how this protocol runs on real quantum computing hardware. New eavesdropping schemes were proposed and modeled.

This article lays the foundation for Extended Relativity (ER) – a unified geometric approach to the electromagnetic and gravitational field and relativistic dynamics in them. We explain here the basic tenets of ER, including the influenced spacetime of an object and the Extended Principle of Inertia. These two new ideas enable a unified theory of these fields. We introduce local scaling functions for describing the geometry of a spacetime influenced by a field and construct a simple, universal local scaling function which unifies electromagnetism and gravity. We recover the full electromagnetic theory, including Maxwell’s equations. For gravitation, ER passes all of the tests of General Relativity. Despite the non-linearity of relativistic gravitation, we obtain a method of combining fields from multiple sources. Finally, we identify the differences in the relativistic treatment of the electromagnetic field by Special Relativity and of the gravitational field by General Relativity and indicate how these differences are resolved in ER.

We investigate the Friedmann–Lemaitre–Robertson–Walker cosmological models within the framework of Rastall gravity incorporating particle creation. The modified field equations for Rastall gravity are derived and exact solutions are obtained under various choices of scale factors. The qualitative behaviour of our solutions depends on the Rastall coupling parameter ψ=kλ. Following the literature, we have restricted the Rastall coupling parameter ψ(k=1) to the range −0.0001 < ψ < 0.0007 at 68% CL from CMB+BAO data. Further, we have discussed the distinct physical behaviour of the derived models in detail.

To understand the mystery of final unification, in our earlier publications, we proposed two bold concepts: 1) There exist three atomic gravitational constants associated with electroweak, strong and electromagnetic interactions. 2) There exists a strong elementary charge in such a way that its squared ratio with normal elementary charge is close to reciprocal of the strong coupling constant. In this paper we propose that, can be considered as a compound physical constant associated with proton mass, electron mass and the three atomic gravitational constants. With these ideas, an attempt is made to understand nuclear stability and binding energy. In this new approach, nuclear binding energy can be fitted with four simple terms having one unique energy coefficient with a formula, where is an estimated mean stable mass number. With this new approach, Newtonian gravitational constant can be estimated in a verifiable approach with a model relation of the form, where is the Fine structure constant. Estimated and is 62 ppm higher than the CODATA recommended It needs further investigation. Proceeding further, an attempt is made to fit the recommended quark masses.

We report a photonic-based radio frequency (RF) arbitrary waveform generator (AWG) using a soliton crystal micro-comb source with a free spectral range (FSR) of 48.9 GHz. The comb source provides over 80 wavelengths, or channels, that we use to successfully achieve arbitrary waveform shapes including square waveforms with a tunable duty ratio ranging from 10% to 90%, sawtooth waveforms with a tunable slope ratio of 0.2 to 1, and a symmetric concave quadratic chirp waveform with an instantaneous frequency of sub GHz. We achieve good agreement between theory and experiment, validating the effectiveness of this approach towards realizing high-performance, broad bandwidth, nearly user-defined RF waveform generation.

Galaxies are huge physical systems having dimensions of many tens of thousands of light years. Thus any change at the galactic center will be noticed at the rim only tens of thousands of years later. Those retardation effects seems to be neglected in present day galactic modelling used to calculate rotational velocities of matter in the rims of the galaxy and surrounding gas. The significant differences between the predictions of Newtonian instantaneous action at a distance and observed velocities are usually explained by either assuming dark matter or by modifying the laws of gravity (MOND). In this paper we will show that taking general relativity seriously without neglecting retardation effects one can explain the apparent excess matter leading to gravitational lensing in both galaxies and galaxy clusters.

In this study, a new structure is proposed based on the body-centered cubic (BCC) lattice structure: adding a cubic truss in the center of the BCC structure, which is denoted by TLC (Truss-lattice-cube). The different dimensions of the central cube can affect the mechanical properties of the lattice structure notably. With a fixed length (15mm) of a unit cell, the optimal size for the central cube is determined to be 5 mm. Quasi-static compressive tests are performed on specimens made of Polylactic Acid (PLA) using additive manufacturing technology. The deformation characteristics of the new structure is analyzed in detail by experiments and numerical simulations. Compared to the BCC structure, the mechanical properties of the TLC structure are significantly improved. The initial flow stress of the TLC has been increased by 122% at a strain of 0.1; the specific strength has been enhanced by 293% at a strain of 0.5; and the specific energy absorption has been improved by 312% at the strain of 0.6. Printing defects in the lattice structure could deteriorate the mechanical property remarkably. In this work, incorporation of microcracks into the finite element model makes the simulation capture the influence of printing defects and improve the predictive accuracy of simulation significantly.

When there is uncertainty in the value of parameters of the input random components of a stochastic simulation model, two-level nested simulation algorithms are used to estimate the expectation of performance variables of interest. In the outer level of the algorithm (n) observations are generated for the parameters, and in the inner level (m) observations of the simulation model are generated with the value of parameters fixed at the value generated in the outer level. In this article, we consider the case in which the observations at both levels of the algorithm are independent, showing how the variance of the observations can be decomposed into the sum of a parametric variance and a stochastic variance. Next, we derive central limit theorems that allow us to compute asymptotic confidence intervals to assess the accuracy of the simulation-based estimators for the point forecast and the variance components. Under this framework, we derive analytical expressions for the point forecast and the variance components of a Bayesian model to forecast sporadic demand; and we use these expressions to illustrate the validity of our theoretical results by performing simulation experiments using this forecast model.

The study of co-fusion was one of the essential topics in the history of metallurgy in China. Simulation experiments had been an essential concept in the study of the co-fusion steelmaking process. This paper mainly studied the simulation experiments of co-fusion from two aspects: the replication of co-fusion swords by three different methods, and the micro-analysis of the co-fusion samples. The experimental results indicated that several co-fusion swords could be made by different processes, but the carbon content and surface hardness were quite different. During repeated forging welded, the microstructure of the samples transformed from laminated to homogenized, finally the steel with a uniform carbon content was obtained. It was challenging to find the characteristics of co-fusion from the homogenized samples. The results prompted people to rethink the microstructure characteristics of ancient co-fusion artifacts.

This paper studies the impact of agricultural subsidies and product certification on the use rate of green pesticides based on experimental economics. We found that agricultural subsidies effectively increased the utilization rate of green pesticides. If the agricultural subsidies raised from 20% to 100%, the green pesticides’ using rate increased by 438.51%. We also found that product certification increased the utilization rate of green pesticides by 376.16%%.The increase of agricultural subsidies is more effective than the product certification. Under a higher proportion of agricultural subsidies, farmers’ behavior will maintain “status bias”. Therefore, there are three suggestions proposed. Firstly, because of high price of green pesticides and lower production, the subsidies for agricultural materials should raise greatly to effectively improve the utilization rate of green pesticides. It is recommended that green pesticide provided free of charge in some wealthy areas. Secondly, both subsidies and product certification can improve the use rate of green pesticides. However, since the effect of agricultural subsidies is better than product certification, and farmers may have status bias. Therefore, it is recommended to give priority to the substantial increase on the proportion of agricultural subsidies, and then to product certification.

Micro/Nano Robot is an intelligent and efficient microrobot that can perform specific tasks under the influence of external stimuli. Depending on the application scenarios, the microrobot can adaptively transform into appropriate functional forms under different external stimuli, thus perfectly matching the needs. To date, microbots have been widely used in targeted therapy, drug delivery, tissue engineering, environmental remediation, and other fields. Although the applications of microrobots are promising, there are only a few reviews that can focus on the preparation methods and driving mechanisms. Therefore, it is necessary to outline the current status of the development of these microrobots in order to provide some new insights for the further development of the field. Therefore, this paper reviews the research progress of microrobots in terms of preparation methods, stimulus response mechanisms and applications, and highlights the applicability of different preparation methods and stimulus types. Finally, the current challenges faced by microrobots are highlighted and possible solutions are proposed to facilitate the practical application of microrobots.

When describing the tribological behaviour of technical surfaces, the need for full length scale microtopographic characterization often arises. The self-affine of surfaces and the characterization of self-affine by a fractal dimension and its implantation into tribological models are commonly used. The goal of our present work was to determine the frequency range of fractal behaviour of surfaces by analysing the microtopographic measurements of a brake plunger. We also wanted to know if the bifractal and multifractal behaviour can be detected in real machine parts. As a result, we developed a new methodology for determining the fractal range boundaries to separate the nano- and micro-roughness. In order to reach our goals, we used atomic force microscope (AFM) and stylus instrument to provide measurements in wide frequency range (19 nm - 3 mm). As a result of the power spectral density (PSD) based fractal evaluation, it was found that the examined surface could not be characterized by a single fractal dimension and that we developed a methodology for stopping the margin of validity of each fractal dimension, and we also developed a methodology for determining the limits of validity of certain fractal dimensions.

A micro decision-making utility model under uncertainty is presented as a complementary foundation for macro coronavirus models. The micro model consists of two functions, a risk averse utility function depending on wellness and a wellness random output which is a function of the input variable called “treatment” consisting of such elements as social distance, washing hands, wearing a face mask, and others. The decision maker selects a level of treatment that maximizes her/his expected utility, given the probabilities of the respective outputs. The focus is on how changes in a person’s psychological attitude towards the macro determined (announced) probabilities affects the optimum results of the model. Such changes create a micro-macro dynamic interaction which is briefly outlined. A short discussion of the model’s behavioral implications for health policy is also given.

Inspired by works of W. H. Zurek and others, a mathematical, physical theory, entirely within a quantum mechanical formalism, is proposed for cognitive processes in terms of an abstract Hilbert-space for the conscious state that is an exact replica of the Hilbert-space for the neuronic physical state. Thus, any actual state of consciousness arises by its formal alignment (identification) with some-one in the set of the neuronic states, with the latter undergoing perpetual changes in the wake of life-long experiences. It is posited that these changes become expressed by an increase in the number of ordered, coherent neuronic states at the expense of the pre-ordinal random neuronic states. Changes, transitions between states are induced by a Gorini-Kossakowski-Sudarshan-Lindblad formalism, which is also instrumental in the effect of the conscious state on bodily actions. The paradigmatic findings of R.N. Shepard (1958 - 2011) and of S. Sternberg (1966 - 2016) for long- and short-term recalls are interpreted within the model.

The redshifted 21 cm line signal is a powerful probe of the cosmic dawn and the epoch of reionisation. The global spectrum can potentially be detected with a single antenna and spectrometer. However, this measurement requires an extremely accurate calibration of the instrument to facilitate the separation of the 21 cm signal from the much brighter foregrounds and possible variations in the instrument response. Understanding how the measurement errors propagate in a realistic instrument system and affect system calibration is the focus of this work. We simulate a 21 cm global spectrum observation based on the noise wave calibration scheme. We focus on how measurement errors in reflection coefficients affect the noise temperature, and how typical errors impact on the recovery of the 21 cm signal, especially in the frequency domain. Results show that for our example set up, a typical VNA measurement error in the magnitude of the reflection coefficients of the antenna, receiver, open cable which are 0.001, 0.001, 0.002 (linear) respectively would result in a 200 mK deviation on the detected signal, and a typical measurement error of 0.48∘, 0.78∘, 0.15∘ in the respective phases would cause a 40 mK deviation. The VNA measurement error can greatly affect the result of a 21 cm global spectrum experiment using this calibration technique, and such a feature could be mistaken for or be combined with the 21 cm signal.

A physical scrutiny of experimental results published in Physical Review Letters (December 2015, M. Giustina, et al., Phys. Rev. Lett. 115, 250401, and L. K. Shalm et al., Phys. Rev. Lett. 115, 250402) is undertaken. These articles reported that measured outcomes were fitted with quantum states possessing a dominant component of non-entangled photons, thereby contradicting their own claim of quantum nonlocality. With probabilities of photon detections lower than 0.1 %, the alleged quantum nonlocality cannot be classified as a resource for developing quantum computing devices, despite recent publicity. Experimental evidence of a feasible process for quantum-strong correlations has been identified (M. Iannuzzi, et al., Phys. Lett. A, 384 (9), 126200, 2020) in terms of correlations between independent and multi-photon states evaluated as Stokes vectors on the Poincaré sphere. As single-photon sources are not needed, the design and implementation of quantum computing operations will be significantly streamlined.

Quantum theory predicts a whole class of non-local phenomena, observable via coincident detection of EPR-type systems. An important feature of these observations is their non-signaling character. Technically, non-local phenomena should only be observable for post-selected sub-ensembles, rather than for complete projections. Otherwise, superluminal telegraphy becomes possible. Yet, a couple of recent Bell experiments reported the observation of quantum non-locality for 100% of the detected events. Does it follow that signaling non-locality is possible? If so, was quantum theory falsified? This puzzle is solved by revisiting the interpretation of the spin projection operator, with special focus on its dual nature (combining spectral decomposition with spectral transformation). “Component switching” is not a loophole, but rather a requirement of quantum mechanics in this context, because sharp spin projections are partial (as well as partially overlapping). Surprisingly, it is possible to pre-select incompatible statistical sub-ensembles with heralded detection and to reveal the same behavior as in post-selected observations. Therefore, Bell experiments confirm the predictions of quantum theory without violating the non-signaling principle.

Many scientific and technological problems are studied with the help of computer codes that simulate the phenomena of interest rather than via traditional laboratory experiments. Such models play an important role in neuroscience where they are used to mimic brain function from the sub-cellular to the macroscopic level. Exploration with computer models carries with it a number of statistical challenges: where to sample the input space for the simulator, how to make sense of the data that is generated, how to estimate unknown parameters in the model, how to validate a model. The simulator setting also has some unique problems and possibilities. This review paper describes statistical research on these issues and how that work might be applied to neural simulations.

We present a tutorial to realize a multidimensional fitting procedure capable of extracting all the relevant information contained in a sequence of charged particle images acquired as a function of time in femtosecond pump-probe experiments. The images are reproduced using a 3D fitting method, which provides the velocity (or center-of-mass kinetic energy) and angular distributions contained in the images and their time evolution. A detailed example of the method is shown through the analysis of the time-resolved predissociation dynamics of CH₃I on the B-band origin [Gitzinger et al., J. Chem. Phys. 133, 234313 (2010)]. We show that the multidimensional approach is essential for the analysis of complex images that contain several overlapping contributions where reduced dimensionality analyses cannot provide a reliable description of the features present in the image sequence. This methodology can be generalized to many types of multidimensional data analysis.

Background: Benveniste’s biology experiments suggested the existence of molecular-like effects without molecules (“memory of water”). In this article, it is proposed that these disputed experiments could have been the consequence of a previously unnoticed and non-conventional experimenter effect. Methods: A probabilistic modelling is built in order to describe an elementary laboratory experiment. A biological system is modelled with two possible states (“resting” and “activated”) and exposed to two experimental conditions labelled “control” and “test”, but both biologically inactive. The modelling takes into account not only the biological system, but also the experimenters. In addition, an outsider standpoint is adopted to describe the experimental situation. Results: A classical approach suggests that, after experiment completion, the “control” and “test” labels of biologically-inactive conditions should be both associated with “resting” state (i.e. no significant relationship between labels and system states). However, if the fluctuations of the biological system are also considered, a quantum-like relationship emerges and connects labels and system states (analogous to a biological “effect” without molecules). Conclusions: No hypotheses about water properties or other exotic explanations are needed to describe Benveniste’s experiments, including their unusual features. This modelling could be extended to other experimental situations in biology, medicine and psychology.

A new formalism is introduced that makes it possible to elucidate the physical and geometric content of quantum spacetime. It is based in the Minimum Group Representation Principle (MGRP). Within this framework new results for entanglement and geometrical/topological phases are found and implemented in cosmological and black hole space-times. Our main results here are: {\bf(i)} We find the Berry phases for inflation and for the cosmological perturbations and express them in terms of the observables, as the spectral scalar and tensor indices, $n_S$ an $n_T$, and the tensor to scalar ratio $r$. The Berry phase for de Sitter inflation is imaginary with the sign describing the exponential acceleration. {\bf(ii)} The pure entangled states in the minimum group (metaplectic) $Mp(n)$ representation for quantum de Sitter space-time and black holes are found. {\bf(iii)} For entanglement, the relation between the Schmidt type representation and the physical states of the $Mp(n)$ group is found: This is a {\it new non-diagonal} coherent state representation complementary to the known Sudarshan diagonal one. {\bf(iv)} Mean value generators of $Mp(2)$ are related to the adiabatic invariant and topological charge of the spacetime (matrix element of the transition $-\infty < t < \infty$). {\bf(v)} The basic {\it even} and {\it odd} $n$-sectors of the Hilbert space are intrinsic to the quantum spacetime and its discrete levels (in particular continuum for $n \rightarrow \infty$), they do not require any extrinsic generation process as the standard Schrodinger cat states, and are {\it entangled}. {\bf(vi)} The gravity or cosmological domains in one side and another of the Planck scale are {\it entangled}. Examples: The quantum primordial trans-Planckian de Sitter vacuum and the classical late de Sitter vacuum today; the central quantum gravity reqion and the external classical gravity region of black holes. The classical and quantum dual gravity regions of the space-time are entangled. {\bf(vii)} The general classical-quantum gravity duality is associated to the Metaplectic $Mp(n)$ group symmetry which provides the complete full covering of the phase space and of the quantum space-time mapped from it.

There are gravitational field and baryonic matter (star, planet, gases etc.) in our world; gravitational field is much more fundamental for that the relativistic mass of the gravitational field of a neutron star is almost 10²¹ times the mass of the neutron star. And, it is astonishing that the relativistic mass density of the gravitational field on the surface of a neutron star can be larger than the mass density of the neutron star. It is well known that, in the weak gravitational field a light line appears a straight line while in the strong field it is a curved line. It is stressed that the result measured in the strong field is more fundamental for that in a galaxy the measurable object is generally with strong field. It results in that the way that the result measured on the Earth with weak field is used as the universal standard need be revised as gravity is studied in the scale of a galaxy. It seems that a new theory of gravity need be developed for the new observations.

We analyze the R + R2 model of quantum gravity where terms quadratic in the curvature tensor are added to the General Relativity action. This model was recently proved to be a self-consistent quantum theory of gravitation, being both renormalizable and unitary. The model can be made practically indistinguishable from General Relativity at astrophysical and cosmological scales by the proper choice of parameters.

We have recently presented a unified quantum gravity theory [1]. Here we extend on that work and present an even simpler version of that theory. For about hundred years, modern physics has not been able to build a bridge between quantum mechanics and gravity. However, a solution may be found here; we present our quantum gravity theory, which is rooted in indivisible particles where matter and gravity are related to collisions and can be described by collision space-time. In this paper, we also show that we can formulate a quantum wave equation rooted in collision space-time, which is equivalent to mass and energy.The beauty of our theory is that most of the main equations that currently exist in physics are not changed (in terms of predictions), except at the Planck scale. The Planck scale is directly linked to gravity and gravity is, surprisingly, actually a Lorentz symmetry as well as a form of Heisenberg uncertainty break down at the Planck scale. Our theory gives a dramatic simplification of many physics formulas without altering the output predictions. The relativistic wave equation, the relativistic energy momentum relation, and Minkowski space can all be represented by simpler equations when we understand mass at a deeper level. This not attained at a cost, but rather a reflection of the benefit in having gravity and electromagnetism unified under the same theory.

After a long a glorious history, marked by the first direct proofs of neutrino existence and of the mixing between the first and third neutrino generations, the reactor antineutrino experiments are still well alive and will continue to give important contributions to the development of elementary particle physics and astrophysics. In parallel to the SBL experiments, that will be dedicated mainly to the search for sterile neutrinos, a new kind of experiments will start playing an important role: the medium baseline reactor experiments, aiming to study the neutrino mass ordering. The first example of this kind, the liquid scintillator JUNO experiment, characterized by a very high mass and unprecedented energy resolution, will soon start data taking in China. Its main aspects are discussed here, together with its potentialities for what concerns the mass ordering investigation and also the other issues that can be studied with this detector, spanning from the accurate oscillation parameter determination, to the study of solar neutrinos, geoneutrinos, atmospheric neutrinos and neutrinos emitted by supernovas and to the search for signals of potential Lorentz invariance violation.

In recent years retarded gravity has explained many of the mysteries surrounding the "missing mass" related to galactic rotation curves, the Tully-Fisher relations, and gravitational lensing phenomena. Indeed a recent paper analyzing 143 galaxies, has demonstrated that retarded gravity will suffice to explain the galaxies rotation curves without the need to postulate dark matter for multiple types of galaxies. Moreover, it also demystified the "missing mass" related to galactic clusters and elliptic galaxies in which excess matter wad derived through the virial theorem. Here we give a mathematical criterion which specifies the cases for which retardation is important for gravity (and when it is not). The criterion takes the form of an "uncertainty" relation.

We develop a renormalizable model of Quantum General Relativity (QGR). We do this by building on earlier work with quantum electrodynamics (QED). Working with the Feynman path integral (FPI) approach to QED, we generalize the paths from varying in space to varying in space and time. This gives the standard results plus dispersion in time of order attoseconds or left. Over longer times, the dispersion in time averages out, but at attosecond times it should be detectable with current technology. As an unexpected but welcome side-effect, the approach caused the usual loop integrals to be finite. Since the usual UV divergences are significantly harder to renormalize in QGR than in QED, and since using paths in time plus space is definitely more in keeping with the general spirit of GR, we here apply the same approach to QGR. We show that with an appropriate choice of gauge (trace-reversed de Donder gauge) we can extend the earlier results to include QGR. Sub-attosecond measurements of individual gravitons are not within our reach, but at least the ultraviolet divergences in QGR are contained in the same way. We have therefore a renormalizable model of QGR

We introduce quantum spatio-temporal dynamics (QSD) as modeled by the Nexus Paradigm (NP) of quantum gravity to resolve the problem of energy- momentum localization in a gravitational field. Currently, the gravitational field as described using the language of geometry modeled under General Relativity (GR) fails to provide a generally accepted definition of energy-momentum. Attempts at resolving this problem using geometric methods have resulted in various energy-momentum complexes whose physical meaning remain dubious since the resulting complexes are non-tensorial under a general coordinate transformation. In QSD, the tangential manifold is the affine connection field in which energy-momentum localization is readily defined. We also discover that the positive mass condition is a natural consequence of quantization and that dark energy is a Higgs like field with negative energy density everywhere. Finally, energy-momentum localization in quantum gravity shows that a free falling object will experience large vacuum fluctuations (uncertainties in location) in strong gravity than in weak gravity and that the amplitudes of these oscillations defines the energy of the free falling object.

The general theory of relativity (GR) is symmetric under smooth coordinate transformations also known as diffeomorphisms. The general coordinate transformation group has a linear subgroup denoted the Lorentz group of symmetry which is maintained also in the weak field approximation to GR. The dominant operator in the weak field equation of GR is thus the d'Alembert (wave) operator which has a retarded potential solution. Galaxy Clusters are huge physical systems having dimensions of many hundreds of millions of light years. Thus any change at the cluster center will be noticed at the rim only hundreds of millions of years later. Those retardation effects are neglected in present day cluster modelling and in particular are neglected in virial calculations used to relate mass and velocities on the cluster. The significant differences between the predictions of Newtonian instantaneous action at a distance and observed velocities are usually explained by either assuming dark matter or by modifying the laws of gravity (MOND). In this paper we will show that taking general relativity seriously without neglecting retardation effects one can explain the velocities in a galactic cluster without postulating dark matter. It should be stressed that the current approach does not require that velocities, $v$ are high, in fact the vast majority of cluster bodies are substantially subluminal. In other words, the ratio of $\frac{v}{c} \ll 1$. Typical velocities in galaxies are less than ~1000 km/s, which makes this ratio $0.01$ or smaller. However, one should consider the fact that every gravitational system even if it is made of subluminal bodies has a retardation distance, beyond which the retardation effect cannot be neglected. Every natural system such as stars and galaxies and even galactic clusters exchange mass with its environment. For example, the sun losses mass through the solar wind and galaxies accrete gas from the intergalactic medium. This means that all natural gravitational systems have a finite retardation distance. The question is thus quantitative, how large is the retardation distance? The change of mass of the sun is quite small and thus the retardation distance of the solar system is quite large allowing us to neglect retardation effects within the solar system. However, for galaxies and galaxy clusters the retardation distance is within the system itself and cannot be neglected.

In a recent paper we have a shown that the flattening of galactic rotation curves can be explained by retardation. However, this will rely on a temporal change of galactic mass. In our previous work we have kept only second order terms of the retardation time in our analysis, while higher terms in the Taylor expansion where not considered. Here we consider analysis to all orders and show that indeed a second order analysis will suffice, and higher order terms can be neglected.

Einstein’s theory of general relativity describes the gravitational field around massive objects ( like Earth) as a curvature in the spacetime. But it leaves the following question unanswered; why is the spacetime curved by a mass? Through a theory that has been introduced recently, regarding a medium for a light propagation, a simple answer is introduced. It depends on redefining the rest energy for a massive object ( like a planet) as new form of kinetic energy. For a static and spherically symmetric object, with a specific radius(

In this work, we explore a the different forms of a new type of modified gravity, namely f(φ) gravity. We construct the Big Rip type for the energy density and the curvature of the universe. We show that dark energy is a result of the transformation of the field φ mass (dark matter) to energy. In addition, we provide that Ω_{m}≈0,050, Ω_{DM}≈0,2, Ω_{DE}≈0,746, is in excellent agreement with observation data. We explore a generalized formalism of braneworld modified gravity. We also construct a new field equations, which generalize the Einstein field equations. We provide a relation between the extra dimension in 3-brane with the vacuum energy density. We show that the energy density of matter depends directly on the number of dimensions. We manage to find the value of the Gauss-Bonnet coupling α=1/4 which is a good agreement with the results in the literature, this correspondence creates a passage between f(R) gravity and Gauss-Bonnet gravity, this comparison leads to a number of bulk dimensions equal to D=10¹²¹+4.

In quantum gravity perturbation theory in Newton's constant $G$ is known to be badly divergent, and as a result not very useful. Nevertheless, some of the most interesting phenomena in physics are often associated with non-analytic behavior in the coupling constant and the existence of nontrivial quantum condensates. It is therefore possible that pathologies encountered in the case of gravity are more likely the result of inadequate analytical treatment, and not necessarily a reflection of some intrinsic insurmountable problem. The nonperturbative treatment of quantum gravity via the Regge-Wheeler lattice path integral formulation reveals the existence of a new phase involving a nontrivial gravitational vacuum condensate, and a new set of scaling exponents characterizing both the running of $G$ and the long-distance behavior of invariant correlation functions. The appearance of such a gravitational condensate is viewed as analogous to the (equally nonperturbative) gluon and chiral condensates known to describe the physical vacuum of QCD. The resulting quantum theory of gravity is highly constrained, and its physical predictions are found to depend only on one adjustable parameter, a genuinely nonperturbative scale $\xi$ in many ways analogous to the scaling violation parameter $\Lambda_{\bar MS} $ of QCD. Recent results point to significant deviations from classical gravity on distance scales approaching the effective infrared cutoff set by the observed cosmological constant. Such subtle quantum effects are expected to be initially small on current cosmological scales, but could become detectable in future high precision satellite experiments.

A classical origin for the Bohmian quantum potential, as that potential term arises in the quantum mechanical treatment of black holes and Einstein-Rosen (ER) bridges, can be based on 4th-order extensions of Einstein's equations. In Bohm's ontological interpretation, black hole radiation, and the analogous tunneling process of quantum transmission through an ER bridge, are classically allowed if the dynamics are modified to include such a quantum potential. The 4th-order extension of general relativity required to generate the quantum potential is given by adding quadratic curvature terms with coefficients that maintain a fixed ratio, as their magnitudes approach zero. Quantum transmission through the classically non-traversable bridge is replaced by classical transmission through a traversable wormhole. If entangled particles are connected by a Planck-width ER bridge, as conjectured by Maldacena and Susskind, then the classical wormhole transmission effect gives the ontological nonlocal connection between the particles posited in Bohm's interpretation of their entanglement. It is hypothesized that higher-derivative extensions of classical gravity can account for the nonlocal part of the quantum potential generally.

In this article a simplified view is given on Verlinde’s entropic gravity. It reveals several shortcomings in the theory. This holds in particular for the inclusion of the dark matter effect in the derived modified expression for the Newtonian gravitational acceleration. Although the merit of the entropic view on gravity is recognized, the proposed explicit axiomatic hypothesis as a basis is criticized. There is no reason why it should be preferred above Einstein’s Field Equation.

Synchrotron radiation computed tomography (SRCT) allows more accurate calcified plaque and coronary stenosis assessment as a result of its superior spatial resolution, however, typical micro-computed tomography (micro-CT) systems have even higher resolution. The purpose of this study was to compare performance of high-resolution micro-CT with SRCT in the assessment of calcified plaques and a previously published dataset of coronary stenosis assessment. This experimental study involved micro-CT scanning of three-dimensional printed coronary artery models with calcification in situ used in our previously published SRCT study on coronary stenosis assessment. Measurements of coronary stenosis utilizing both modalities were compared using a paired sample t-test. The degrees of stenosis measured on all but one micro-CT dataset were statistically significantly lower than the corresponding SRCT measurements reported in our previous paper (p&lt;0.0005-0.05). This indicates that the superior spatial resolution of micro-CT was able to further reduce over-estimation of stenosis caused by extensive calcification of coronary arteries and hence false positive results. This study shows that high-resolution micro-CT outperforms SRCT in both calcified plaque and coronary stenosis assessment. This finding will become clinically important for cardiovascular event prediction and enable reclassification of individuals with low and intermediate risk into appropriate risk categories when the technical challenges of micro-CT in clinical practice such as the small field of view and demanding on image processing power are addressed.

Bimetallic Ni/Cu core-shell and Cu-Ni heterostructural micro- and nanoparticles were prepared using two simple successive reduction procedures. Monometallic Ni and Cu particles were synthesized for comparison. The phase constitutions and morphological features of the particles were studied by means of X-ray diffraction, energy-dispersive X-ray spectroscopy and scanning electron microscopy methods. All the obtained mono- and bimetallic particles were applied as electrocatalysts in the electrohydrogenation of p-nitrophenol (p-NPh). An additional electrochemical reduction of copper cations during the hydrogen saturation of Cu-containing particles was established. Some of the prepared particles exhibited high catalytic activity with an increase in the hydrogenation rate of p-NPh by more than 3 times compared to its electrochemical reduction on the non-activated cathode, and p-NPh conversion yielded the maximum values. The main product of p-NPh electrocatalytic hydrogenation over Ni-Cu particles is p-aminophenol, which is an intermediate in the synthesis of many drugs. p-Aminophenol formation is confirmed by UV-Vis spectra.