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Preprint ARTICLE | doi:10.20944/preprints202404.1056.v1

Circulating miR-16 and miR-21 Levels in Multiple Myeloma: Prognostic Significance of Survival and Response to Lenalidomide Treatment.

Annita Ioanna Gkioka, Maria Tsota, Aspasia Koudouna, Alexandros Gkiokas, Christina Aggeliki Mitropoulou, Aikaterini Palaiokrassa, Alexandros Alexandropoulos, Mavra Papadatou-Gigante, Vasiliki Bartzi, Thomais Marina Tryfou, Petros P Sfikakis, George V. Dedoussis, Marie Christine Kyrtsonis

Subject: Biology And Life Sciences, Life Sciences Keywords: Multiple myeloma, miR-16, miR-21, prognosis, lenalidomide, serum expression level, downregulation.

Online: 16 April 2024 (12:01:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0579.v1

Diagnostic Potential of miR-143-5p, miR-143-3p, miR-551b-5p and miR-574-3p in Chemoresistance of Locally Advanced Gastric Cancer: A Preliminary Study

Marlena Janiczek-Polewska, Tomasz Kolenda, Paulina Poter, Joanna Kozłowska-Masłoń, Inga Jagiełło, Katarzyna Regulska, Julian Malicki, Andrzej Marszałek

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: microRNAs; locally advanced gastric cancer; pathological staging; clinical staging; neoadjuvant chemotherapy

Online: 11 June 2024 (08:28:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0506.v1

A Life Course Perspective on the Sexual Development of Young Intersex People

Mir Abe Marinus, Marianne Cense

Subject: Social Sciences, Gender And Sexuality Studies Keywords: Intersex; sexual development; sexual agency; medical treatments; stigma; heteronormativity.

Online: 5 January 2024 (15:16:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0339.v1

A Crucial Role of Proteolysis in Formation of Intracellular Dinitrosyl Iron Complexes

Karolina E. Wójciuk, Jarosław Sadło, Hanna Lewandowska, Marcin Kruszewski

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: K562 cells; electron paramagnetic resonance; nitric oxide; reactive nitrogen species; dinitrosyl iron complexes; chelatable iron; glutathione

Online: 6 February 2024 (13:33:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0532.v2

Myrtus communis Leaves: Source of Bioactives, Traditional Use and their Biological Properties

Mushtaq Mir

Subject: Biology And Life Sciences, Plant Sciences Keywords: natural products; plant extracts; Myrtus communis; medicinal plants; antimicrobial; antioxidants; antiviral; biofilm inhibition

Online: 7 February 2023 (03:33:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0941.v1

Electrolyte Imbalance in Acute Traumatic Brain Injury: Insights from the First 24 Hours

Alina Săcărescu, Mihaela-Dana Turliuc

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: traumatic brain injury; electrolytes; early monitoring; Glasgow Coma Scale; chloride; potassium

Online: 13 August 2024 (14:39:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0073.v1

Prospective Evaluation of Circulating miR-126, mir-197 and mir-223 in Relation to Cardiometabolic Diseases

Widet Helene Gallo, Filip Ottosson, Cecilia Kennbäck, Amra Jujic, Jonathan Esguerra, Lena Eliasson, Olle Melander

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: MicroRNAs; miR-126; mir-197; mir-223; Cardiometabolic Disease; Diabetes; Cardiovascular disease; Atherosclerosis; Inter Media Thickness

Online: 6 December 2021 (12:52:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1876.v1

Numerical Simulation of Flow around a Pitching Airfoil with Combined Morphing Leading Edge and Trailing Edge Wing

Musavir Bashir, Mir Hossein Negahban, Ruxandra Mihaela Botez, Tony Wong

Subject: Engineering, Aerospace Engineering Keywords: Morphing; Unsteady Parameterization; Combined Morphing Leading Edge and Trailing Edge (CoMpLETE); Flow Control

Online: 25 December 2023 (12:58:25 CET)

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An integrated approach to active flow control is proposed by finding both the drooping leading edge and the morphing trailing edge for flow management. This strategy aims to manage flow separation control by utilizing the synergistic effects of both control mechanisms, which we call the Combined Morphing Leading Edge and Trailing Edge (CoMpLETE) technique. This design is inspired by a bionic porpoise nose and the flap movements of the cetacean species. The motion of this mechanism achieves a continuous, wave-like, variable airfoil camber. The dynamic motion of the airfoil's upper and lower surface coordinates in response to unsteady conditions is achieved by combining the thickness-to-chord (t/c) distribution with the time-dependent camber line equation. A parameterization model was constructed to mimic the motion around the morphing airfoil at various deflection amplitudes at stall angle of attack and morphing actuation start times. The mean properties and qualitative trends of the flow phenomena are captured by the transition-SST (Shear Stress Transport) model. The effectiveness of the dynamically morphing airfoil as a flow control approach is evaluated by obtaining the flow field data, such as velocity streamlines, vorticity contours, and aerodynamic forces. Different cases are investigated for the CoMpLETE morphing airfoil, which evaluates the airfoil’s parameters, such as its morphing location, deflection amplitude, and morphing starting time. The morphing airfoil’s performance is analyzed to provide further insights into the dynamic lift and drag force variations at pre-defined deflection frequencies of 0.5 Hz, 1 Hz, and 2 Hz. The findings demonstrate that adjusting the airfoil camber reduces streamwise adverse pressure gradients, thus preventing significant flow separation. Although the trailing edge deflection and its location along the chord influence the generation and separation of the Leading-Edge Vortex (LEV), these results show that the combined effect of the morphing leading edge and trailing edge has the potential to mitigate flow separation. The morphing airfoil successfully contributes to the flow reattachment and significantly increases the maximum lift coefficient (c_(l,max))). This work also broadens its focus to investigate the aerodynamic effects of a dynamically morphing leading and trailing edge, which seamlessly transitions along the side edges. The aerodynamic performance analysis is investigated across varying morphing frequencies, amplitudes, and actuation times.

Preprint ARTICLE | doi:10.20944/preprints202403.0736.v1

Tea Grounds as a Waste Biofiller for Natural Rubber

Aleksandra Juszkiewicz, Magdalena Maciejewska

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: tea grounds; natural rubber; tea waste; biofiller; ionic liquids

Online: 13 March 2024 (11:56:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0074.v1

Diversity of HPV 16 L1 in the Asian Region: A Comparative Analysis of Sequences

Rana Özdoğan, Muharrem Okan Çakır, G Hossein Ashrafi, Uğur Bilge

Subject: Biology And Life Sciences, Virology Keywords: Human Papillomavirus, HPV 16, L1, Phylogenetic analysis

Online: 3 March 2024 (18:18:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0011.v1

Simulation Analysis of Solution Transportation Absorption Chiller with the Capacity from 25 RT to 1000 RT

Koji Enoki, Fumi Watanabe, Seigo Tanaka, Atsushi Akiwawa, Toshitaka Takei

Subject: Engineering, Energy And Fuel Technology Keywords: absorption chiller; thermal energy transportation; solution transportation; ammonia-water; COP; simulation

Online: 4 February 2017 (07:49:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0034.v2

A Blockchain-Based Intelligent Machine Learning System for Smart Health Care

Mir Hassan

Subject: Engineering, Control And Systems Engineering Keywords: Blockchain technology; security; Machine learning; Smart System

Online: 17 March 2022 (10:53:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0123.v2

Validation of the Use of Bloom's Revised Taxonomy as a Tool for the Design of Assessment Tests

Bartolomé Pizà-Mir

Subject: Social Sciences, Education Keywords: Bloom; Assessment; Validation

Online: 9 December 2022 (10:10:08 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201607.0078.v2

Analysis between Various Random MIMO Systems Model on the Basis of Channel Capacity

Shree Krishna Acharya

Subject: Engineering, Electrical And Electronic Engineering Keywords: MIMO system Model; 2N–MIMO system model; Outage Probability; Channel Capacity Ratio (CCR)

Online: 10 August 2016 (10:11:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0542.v1

Development of an HPLC Method through the QbD Approach for the Quantification of Honokiol and Metformin Hydrochloride – Method Validation and Pharmaceutical Applications on Oral Dosage Forms

Mousa Sha’at, Adrian Florin Spac, Iulian Stoleriu, Alexandra Bujor, Monica Stamate Cretan, Mihaela Hartan, Lăcrămioara Ochiuz

Subject: Medicine And Pharmacology, Pharmacy Keywords: QbD optimization; HPLC; validation; greenness; assay; dissolution test; metformin hydrochloride; honokiol; oral dosage forms; diabetes mellitus.

Online: 9 July 2024 (06:08:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1217.v1

Tightness of Harary Graphs

Abolfazl Javan, Ali Moeini, Mohammad Shekaramiz

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Network Vulnerability; Tightness; Harary Graphs; Connectivity; Hamiltonian Circuit

Online: 16 August 2024 (08:37:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0049.v1

A New Input Device for Spastics Based on Strain Gauge

Niels Buchhold, Christian Baumgartner

Subject: Engineering, Control And Systems Engineering Keywords: tactile sensors; assistive technologies; power wheelchair; medical systems; robotic; joystick; strain-gauge; spasticity

Online: 14 February 2017 (09:02:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0887.v1

Oral Spirochete Treponema denticola Intraoral Infection Reveals Unique miR-133a, miR-486, miR-126-3p, miR-126-5p miRNA Expression Kinetics during Periodontitis

Chairmandurai Aravindraja, Syam Praveen Kumar Jeepipalli, Krishna Vekariya, Ruben Escalante, Edward K.L. Chan, Lakshmyya Kesavalu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Periodontal disease; miRNAs; NanoString analysis; transient miRNA expression; T. denticola.

Online: 13 July 2023 (05:03:20 CEST)

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miRNAs are major regulators of eukaryotic gene expression, host immunity, and play an important role in the inflammation-mediated pathways in periodontal disease (PD) pathogenesis. Expanding our previous observation with the global miRNA profiling using partial human mouth microbes and lack of in vivo studies involving oral spirochete Treponema denticola induced miRNAs, this study was designed to delineate the global miRNA expression kinetics during progression of periodontitis in mice infected with T. denticola by using NanoString nCounter® miRNA panels. All the T. denticola-infected male and female mice at 8- and 16 weeks demonstrated bacterial colonization (100%) on the gingival surface, and an increase in alveolar bone resorption (p < 0.0001). A total of 70 miRNAs with at least 1.0-fold differential expression/regulation (DE) miRNAs (26 upregulated and 44 downregulated) were identified. nCounter miRNA expression profiling identified 13 upregulated miRNAs (e.g. miR-133a, miR-378) and 25 downregulated miRNAs (e.g. miR-375, miR-34b-5p) in T. denticola-infected mice mandibles during 8-weeks infection whereas 13 upregulated miRNAs (e.g. miR-486, miR-126-5p) and 19 downregulated miRNAs (miR-2135, miR-142-3p) were observed during 16- weeks of infection. One miRNA (miR-126-5p) showed significant difference between 8-and 16-weeks of infection. Interestingly, miR-126-5p has been presented as a potential biomarker in patients with periodontitis and coronary artery disease. Among the 13 upregulated miRNAs, miR-486, miR-126-3p, miR-126-5p were reported in human gingival plaques samples with periodontitis. KEGG analysis revealed various functional pathways of DE miRNAs such as bacterial invasion of epithelial cells, Ras signaling, Fc gamma R- mediated phagocytosis, osteoclast differentiation, adherens signaling and ubiquitin mediated proteolysis. This is the first study of DE miRNAs in mice mandibles at different time-points of T. denticola infection and the combination of three specific miRNAs miR-486, miR-126-3p, miR-126-5p may serve as an invasive biomarker of T. denticola in PD. These miRNAs may have significant role in PD pathogenesis and establishes a link between miRNA, periodontitis, and systemic diseases.

Preprint ARTICLE | doi:10.20944/preprints202212.0306.v1

Emotional Intelligence and Empathy in Pre-primary Teachers: A Pilot Test

Paula Domínguez-Marquez, Bartolomé Pizà-Mir

Subject: Social Sciences, Education Keywords: Empathy; Emotional Education; Emotional Intelligence; Emotional competences; pre-primary Education

Online: 16 December 2022 (14:05:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0128.v1

Screening for Triterpenoid Saponins in Plants Using Hyphenated Analytical Platforms

Bekzod Khakimov, Li Hong Tseng, Markus Godeljohann, Søren Bak, Søren Balling Engelsen

Subject: Biology And Life Sciences, Plant Sciences Keywords: time slice LC-SPE-NMR/MS; GC-MS; LC-MS/MS; triterpenoid saponins; Barbarea vulgaris

Online: 25 November 2016 (10:04:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1897.v1

Autophagy-Associated Markers LC3-II, ULK2 and microRNAs miR-21, miR-126 and miR-374 as a Potential Prognostic Indicator for Glioma Patients

Wajiha Amin, Syed Ather Enam, Sufiyan Sufiyan, Sana Naeem, Altaf Ali Laghari, Mohammad Hamza Bajwa, Kulsoom Ghias, Syed Hani Abidi, Nouman Mughal

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Glioma; Prognostic markers; Autophagy; Micro-RNA; Overall Survival

Online: 29 August 2023 (03:33:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0125.v1

Post-Transcriptional Effects of miRNAs on PCSK7 Expression and Function: miR-125a-5p, miR-143-3p and miR-409-3p as Negative Regulators

Mahshid Malakootian, Parisa Naeli, Seyed Javad Mowla, Nabil G. Seidah

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: PCSK7; miR-125a-5p; miR-143-3p; miR-409-3p; RNA regulator; proprotein convertases

Online: 8 June 2022 (10:45:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0693.v1

miR-1 as a Key Epigenetic Regulator in Early Differentiation of Cardiac Sinoatrial Region

Carlos García-Padilla, Estefanía Lozano-Velasco, Virginio García-López, Amelia Aránega, Diego Franco, Virginio García-Martínez, Carmen López-Sánchez

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: miR-1; epigenetic regulator; cardiac sinoatrial region; molecular mechanisms; HDAC4; Calmodulin; pErk2/MAPK1; Mef2c activity; retinoic acid signaling; cardiac development

Online: 12 March 2024 (10:22:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0126.v1

Overview of the OGC CDB Standard for 3D Synthetic Environment Simulation & Modeling

Sara Saeedi, Steve Liang, David Graham, Michael F. Lokuta, Mir Abolfazl Mostafavi

Subject: Engineering, Control And Systems Engineering Keywords: 3D terrain models; synthetic environment; modeling and simulation; OGC standards; common database

Online: 26 September 2017 (04:13:40 CEST)

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Recent advances in sensor and platform technologies such as satellite systems, unmanned aerial vehicles (UAV), manned aerial platforms, and ground-based sensor networks have resulted in massive volumes of data is produced and collected about the earth. Processing, managing, and analyzing these data is one of the main challenges in 3D synthetic representation used in modeling and simulation (M&S) of the natural environment. M&S devices, such as flight simulators, traditionally require a variety of different databases to provide a synthetic representation of the world. M&S often requires integration of data from a variety of sources stored in different formats. Thus, for simulation of a complex synthetic environment, such as a 3D terrain model, tackling interoperability among its components (geospatial data, natural and man-made objects, dynamic and static models) is a critical challenge. Conventional approaches used local proprietary data models and formats. These approaches often lacked interoperability and created silos of content within the simulation community. Therefore, open geospatial standards are increasingly perceived as a means to promote interoperability and reusability for 3D M&S. In this paper, the Open Geospatial Consortium (OGC) CDB Standard is introduced. “CDB” originally refers to Common DataBase which is currently considered as a name with no abbreviation in the OGC community. The OGC CDB is an international standard for structuring, modeling, and storing geospatial information required in high performance modeling and simulation applications. CDB defines the core conceptual models, use cases, requirements, and specifications for employing geospatial data in 3D M&S. The main features of the OGC CDB Standard are described as run-time performance, full plug-and-play interoperable geospatial data store, usefulness in 3D and dynamic simulation environment, ability to integrate proprietary and open-source data formats. Furthermore, compatibility with the OGC standards baseline reduces the complexity of discovering, transforming, and streaming geospatial data into the synthetic environment and makes them more widely acceptable to major geospatial data/software producers. This paper includes an overview of OGC CDB version 1.0 which defines a conceptual model and file structure for the storage, access, and modification of a multi-resolution 3D synthetic environment data store. Finally, this paper presents a perspective of future versions of the OGC CDB and what the steps are for humanizing the OGC CDB standard with the other OGC/ISO standards baseline.

Preprint ARTICLE | doi:10.20944/preprints201608.0018.v1

Soil Tillage Systems and Wheat Yield in Climate Change Scenarios

Pieranna Servadio, Simone Bergonzoli, Claudio Beni

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: soil tillage; tractors; soil water content; physical soil properties; GPS; energy requirement; CO2 emission

Online: 2 August 2016 (12:50:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0287.v1

MEF2C Directly Interacts with Pre-miRNAs and Distinct RNPs to Post-transcriptionally Regulate miR-23a-miR-27a-miR-24-2 microRNA Cluster Members Expression

Estefanía Lozano-Velasco, Carlos Garcia-Padilla, Miguel Carmona-Garcia, Alba Gonzalez-Diaz, Angela Arequipa-Rendon, Amelia Eva Aránega, Diego Franco

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Mef2c; microRNAs; RNPs

Online: 6 October 2023 (05:46:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0333.v1

The Relationship between Job Strain and Ischemic Heart Disease, Mediated by Endothelial Dysfunction Markers and Imaging

PALOMA MOISII, IRINA JARI, ANDRA MARA URSU, ALEXANDRU GRATIAN NAUM

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronary artery disease; cardiovascular risk; job strain; high sensitivity C reactive protein; microalbuminuria

Online: 4 April 2024 (09:16:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0331.v1

Association of miR-497-5p and miR-4417 Expression in Oral Squamous Cell Carcinoma and Clinical Parameters

Cintia Chamorro-Petronacci, Mario Pérez-Sayáns, M Elena Padin-Iruegas, J Manuel Suarez-Peñaranda, Alejandro I Lorenzo-Pouso, Andres Blanco-Carrion, Abel Garcia-Garcia

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: microRNA; mouth neoplasms; expression profile; microarray analysis.

Online: 15 October 2018 (17:59:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0999.v1

miR-223, but Not miR-195, Modulates Myocardial-Induced Proepicardial Cell Migration

Estefanía Lozano-Velasco, Amelia Aranega, Diego Franco

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: microRNAs; proepicardium; cell migration

Online: 12 January 2024 (09:09:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0229.v1

Numerical Coupling between a FEM Code and the FVM Code OpenFOAM by Using the MED Library

Sandro Manservisi, Giacomo Barbi, Antonio Cervone, Federico Giangolini, Lucia Sirotti

Subject: Engineering, Energy And Fuel Technology Keywords: CFD; Code coupling; Conjugate Heat Trasfer

Online: 3 April 2024 (08:09:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1035.v1

The Hydroxyapatite-Filled Acrylonitrile-Butadiene Rubber Composites with Improved Cure Characteristics and Reduced Flammability

Magdalena Maciejewska, Przemysław Rybiński, Anna Sowińska-Baranowska

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: acrylonitrile-butadiene rubber; hydroxyapatite; filler; flammability; silane; ionic liquid; surfactant; vulcanization; dispersibility

Online: 12 July 2024 (12:08:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0462.v1

Diagnostic Significance of hsa-miR-21-5p, hsa-miR-192-5p, hsa-miR-155-5p, hsa-miR-199a-5p Panel and Ratios in Hepatocellular Carcinoma on top of Liver Cirrhosis in HCV Infected Patients

Mona A. Eldosoky, Reham Hammad, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. AbdelHamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A Shaheen, Areej Rushdi, Reem M Ahmed, Alzahra Abdelbadea, Neamat A. Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I Abo-Elkheir, Samy Zaky, Nadia M. Hamdy, Claude Lambert

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HCC; hsa-miR-21-5p; hsa-miR-155-5p; hsa-miR-192-5p; hsa-miR-199a-5p; liver cirrhosis; HCV; AFP-negative HCC

Online: 25 November 2022 (02:26:16 CET)

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Hepatocellular carcinoma (HCC) early diagnosis is challenging. Moreover, for patients with al-pha-fetoprotein (AFP)-negative HCC, this challenge is augmented. MicroRNAs (miRs) profile may serve as potential HCC molecular markers. We aimed to assess plasma homo sabines (hsa)-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, hsa-miR-199a-5p expression levels, as panel of biomarkers for HCC in chronic hepatitis C virus (CHCV) patients with liver cirrhosis (LC), es-pecially AFP-negative HCC cases, a step toward non-protein coding (nc) RNA precision medicine. Subjects and Methods: 79 patients enrolled with CHCV infection with LC, subclassified into LC group without HCC (n=40) and LC with HCC (n=39) in comparison with 15 apparently healthy control subjects. Real-time quantitative PCR was used to measure plasma hsa-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p. Results: Plasma hsa-miR-21-5p and hsa-miR-155-5p demonstrated significant upregulation, while hsa-miR-199a-5p demonstrated significant downregulation in the HCC group (n=39) when compared to LC group (n=40). Hsa-miR-21-5p expression was positively correlated with serum AFP, insulin, and insulin re-sistance (r=0.5, p<0.001, r=0.334, p=0.01, and r=0.303, p=0.02, respectively). According to the ROC curves, for differentiating HCC from LC, combining AFP with each of hsa-miR-21-5p, hsa-miR-155-5p, and miR199a-5p improved the diagnostic sensitivity to 87%, 82%, and 84%, re-spectively, vs 69% for AFP alone, with an acceptable specificity of 77.5%, 77.5%, and 80%, respec-tively, and AUC= 0.89, 0.85, and 0.90, respectively vs. 0.85 for AFP alone. Hsa-miR-21-5p/hsa-miR-199a-5p and hsa-miR-155-5p/hsa-miR-199a-5p ratios discriminated HCC from LC at AUC=0.76 and 0.71, respectively, with sensitivities=94% and 92%, and specifici-ties=48% and 53%, respectively. Upregulation of plasma hsa-miR-21-5p was considered as an independent risk factor for HCC development [OR=1.198(1.063–1.329), p=0.002]. Conclusion: Combining each of hsa-miR-21-5p, hsa-miR-155-5p, and hsa-miR-199a-5p with AFP made possi-ble to identify HCC development in LC patients’ cohort with higher sensitivity than using AFP alone. Hsa-miR-21-5p/hsa-miR-199a-5p and hsa-miR-155-5p/hsa-miR-199a-5p ratios are poten-tial HCC molecular markers for AFP-negative HCC patients. Hsa-miR-21-5p was linked to insu-lin metabolism in HCC patients’ group as well as being an upregulated independent risk factor for the emergence of HCC from LC in CHCV patients.

Preprint ARTICLE | doi:10.20944/preprints202408.1334.v1

New Spectrophotometric Visible (VIS) Analysis to determine Sodium Valproate from Tablets

CRISTIAN-CATALIN GAVAT

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Sodium valproate; antiepileptic drug; spectrophotometric quantitative analysis method; light yellow azo dye; official declared pure amount; quantitative color reaction; statistical validation procedure

Online: 19 August 2024 (14:27:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0151.v1

Expression and Potential Function of Plasma Exosomal microRNAs (miR-483-5p, miR-671-5p, and miR-150-3p) in a Mouse Mode and in Mesial Temporal Lobe Epilepsy Patients

Shaofeng Yan, Guiyang Liu, Wenyan Xie, Dawei Meng, Hua Zhang, Fangang Meng, Kai Zhang, Yin Jiang, Xin Zhang, Jianguo Zhang

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: epilepsy; exosoma; microRNA

Online: 30 December 2016 (07:43:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0157.v1

Artificial Intelligence-Assisted Optimization and Multiphase Analysis of Polygon PEM Fuel Cells

Ali Jabbary, Nader Pourmahmoud, Mir Ali Asghar Abdollahi

Subject: Engineering, Energy And Fuel Technology Keywords: PEM fuel cell; optimization; CFD; modeling; neural network; performance

Online: 18 April 2022 (06:19:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0265.v1

A Recap of Voltage Stability Indices in the Past Three Decades

Mir Sayed Shah Danish, Tomonobu Senjyu, Sayed Mir Shah Danish, Najib Rahman Sabory, Narayanan K, Paras Mandal

Subject: Engineering, Electrical And Electronic Engineering Keywords: voltage stability; stability index; voltage stability indicator; power system stability, power system monitoring, voltage collapse; blackout, voltage stability classification

Online: 26 January 2019 (09:59:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0374.v1

Patients’ Satisfaction regarding Oral Healthcare Services in the North-East Region of Romania: A Questionnaire Survey

Silviu Catalin Tibeica, Dragoș Ioan Virvescu, Iulian Costin Lupu, Dana Gabriela Budala, Ionut Luchian, Andreea Tibeica, Zinovia Surlari, Elena Mihaela Carausu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: oral health; dental management; quality of life; patient satisfaction; quality management; dental services

Online: 4 April 2024 (12:14:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0845.v1

What to Deconstruct in a Literary Text?: Illustrations from Ira Trivedi's The Great Indian Love Story and India in Love

Sibia Mushtaq Mir, Valiur Rahaman

Subject: Arts And Humanities, Literature And Literary Theory Keywords: Deconstruction; Ira Trivedi; Modern India; Indian English Fiction

Online: 13 August 2024 (08:05:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0301.v1

Dynamic of a Flexible Rotor-Bearing System Supported by Worn Tilting Journal Bearings Experiencing Rub-Impact

Ebrahim Tofighi-Niaki, Mir Saeed Safizadeh

Subject: Engineering, Mechanical Engineering Keywords: Rotor dynamics; Bearing wear; Mixed lubrication; Tilting pad journal bearings

Online: 13 April 2023 (07:21:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1365.v1

Rifampicin Loaded PLGA/Alginate Grafted pNVCL-Based Nanoparticles for Wound Healing

Tudor Bibire, Daniel Vasile Timofte, Radu Dănilă, Alina Diana Panainte, Cătălina Natalia Yilmaz, Nela Bibire, Luminita Agoroaei, Cristina Mihaela Ghiciuc

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: alginate; NVCL; nanoparticle; rifampicin; IC50; wound healing

Online: 19 September 2024 (08:43:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0497.v1

Effectiveness of a Polyphenolic-Enriched Blend on Weight Management and Metabolic Syndrome-Related Parameters in Healthy, Overweight Adults

Alejandro Martínez-Rodríguez, Maria Martínez-Olcina, Manuel Vicente-Martínez, Nuria Asencio-Mas, Pau Navarro, Nuria Caturla, Jonathan Jones

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Hibiscus sabdariffa; Lippia citriodora; weight management; satiety; body fat; cholesterol

Online: 8 April 2024 (07:03:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0332.v1

Differential protective effect of zinc and magnesium for the hepatic and renal toxicity induced by acetaminophen and potentiated with ciprofloxacin in rats

Alexandra Moraru (Ciocan), Diana C. Ciubotariu, Cristina Mihaela Ghiciuc, Catalina Elena Lupusoru, Mihnea Eudoxiu Hurmuzache, Radu Crișan-Dabija

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: magnesium chloride (MgCl2); zinc gluconate (ZnG); liver diseases; kidney diseases

Online: 6 March 2024 (13:55:48 CET)

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Background: The purpuse was to investigate the influence induced by magnesium chloride (MgCl2) and zinc gluconate (ZnG) supplementation on liver and kidney injuries experimentally-induced with acetaminophen (AAPh) and potentiated by ciprofloxacin addition in rats. Material and methods: The experiment was performed on 5 animals groups: group 1 – control, treated for 6 weeks with normal saline, 1mL/kg; group 2 – AAPh, treated for 6 weeks with AAPh, 100 mg/ kg/day; group 3 – AAPh+C, treated AAPh 100 mg/kg/ day for 6 weeks and ciprofloxacin, 50mg /kg/day, only in the last 14 days of the experiment; group 4 – AAPh+C+Mg, with the same treatment as group 3, but, and in the last 14 days, MgCl2 10 mg/ kg/day was added; group 5 – AAPh+C+Zn, with the same treatment as group 3, but, and in the last 14 days, zinc gluconate (ZnG),10 mg/kg/day was added. All administrations were performed by oral gavage. At the end of the experiment, the animals were sacrificed and blood samples were collected for biochemistry examinations. Results: Treatment with AAPh for 6 weeks determined an alteration of the liver function (increases in alanine aminotransferase, aspartate aminotransferase, lactic dehydrogenase and, and gamma-glutamyl transferase) and of renal function (increases in serum urea and creatinine) (P < 0.001 group 2 vs. group 1 for all mentioned parameters). Also, the antioxidant defense capacity was impaired in group 2 vs. group 1 (superoxide dismutase and glutathione peroxidase activity decreased in group 2 vs. group 1, 0.001 < P < 0.01, respectively 0.01 < P < 0.05). The addition of ciprofloxacin, 50 mg/kg/day during the last 14 days resulted in further increases in alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, urea and creatinine (0.01 < P < 0.05, group 3 vs. group 2). MgCl2 provided a slight protection against liver enzymes increase and a more pronounced protection against the increase in serum urea and creatinine (0.001 < P < 0.01 group 4 vs. group 3). MgCl2 provided a slight protection against the decrease in superoxide dismutase (0.01 < P < 0.05 group 4 vs. group 3), but not against decrease of glutathione peroxidase. The improvement of mentioned parameters could also be seen in case of ZnG, to a higher extent especially in the case of alanine aminotransferase and lactic dehydrogenase (0.01 < P < 0.05 group 5 vs. group 4). Conclusions: This study represents a furthermore proof for beneficial effect of magnesium and zinc salts against toxicity induced by different agents, including antibacterials added to the analgesic and antipyretic acetaminophen; the protection is proven on the liver and kidney’s function; the antioxidant profile improvement has a key role, especially in case of zinc gluconate.

Preprint ARTICLE | doi:10.20944/preprints202405.2007.v1

Computing Interface Curvature from Height Functions using Machine Learning with a Symmetry-preserving Approach for Two-phase Simulations

Antonio Cervone, Sandro Manservisi, Ruben Scardovelli, Lucia Sirotti

Subject: Engineering, Energy And Fuel Technology Keywords: curvature computation; volume of fluid; height function; machine learning; neural network

Online: 30 May 2024 (10:58:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0570.v1

Mir-21 Regulates Growth and Migration of Cervical Cancer Cells by RECK Signaling Pathway

Seidy Y. Aguilar-Martínez, Gabriela E. Campos-Viguri, Selma E. Medina-García, Ricardo J. García-Flores, Jessica Deas, Claudia Gómez-Cerón, Abraham Pedroza-Torres, Elizabeth Bautista-Rodríguez, Gloria Fernández-Tilapa, Mauricio Rodríguez-Dorantes, Carlos Pérez-Plasencia, Oscar Peralta-Zaragoza

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cervical cancer; microRNAs; miR-21; RECK; siRNAs

Online: 9 February 2024 (11:20:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0638.v1

Immobilization of Cell Walls with Laccase in L-DOPA-Alginate Beads and Investigation of the Influence of Photopolymeriza-Tion on the Temperature Stability of Immobilized Cells and Their Ability for Textile Dye Decolorization

Nikolina Popović Kokar, Anamarija Nikoletić, Marija Stanišić, Milica Crnoglavac Popović, Radivoje Prodanović

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: algae biomass; alginate; yeast cells; laccase; surface display; hydrogel; photopolymerisation; bioremediation

Online: 9 April 2024 (13:08:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1614.v1

Further Evidence of the Role of myomiRs miR-133a, -133b and -206 Dysregulation in Cardiovascular Disease Development

Paolina Crocco, Alberto Montesanto, Rossella La Grotta, Ersilia Paparazzo, Luca Soraci, Serena Dato, Giuseppe Passarino, Giuseppina Rose

Subject: Biology And Life Sciences, Aging Keywords: CVD; cardiovascular disease; heart failure; stroke; miRNA; myomiRs; miRNA-133a; miRNA-133b; miRNA-206

Online: 20 September 2024 (11:21:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0410.v1

On Efficient Iterative Numerical Methods for Simultaneous Determination of all Roots of Non-Linear Function

Mudassir Shams, Nazir Mir, Naila Rafiq

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Single roots; Distinct roots; Multiple roots; Optimal order; Non-Linear equation; Iterative methods; Simultaneous Methods; Basin of attraction; Computational Efficiency

Online: 27 February 2020 (16:02:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0584.v1

“Prevalence of Dental Caries and Dietary Determinants among 12–16 Years Old Students, a Cross-Sectional Study”

Suela Hoxha, Fatime Hoxha, Jaser Veseli, Xheneta Hoxha

Subject: Public Health And Healthcare, Other Keywords: DMFT; soft drinks; frequency; adolescents

Online: 9 May 2024 (10:34:04 CEST)

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Introduction: Caries is a public health problem in Kosovo among children, Caries is a multifactorial microbial disease and connection of this disease with soft drinks and food habits between children and their poor oral health is very strong. Aim: The aim of present study is to evaluate prevalence of caries among 12 to 16 years old students in municipality of Suhareka and to analyze related risk factors that contribute in occurrence of caries. Material and methods: To observe parameters of soft drink we used experimental method and a cross-sectional study was carried out among 120 adolescents in “Sadri Duhla” elementary school in Duhel and “7 Marsi” elementary school in city of Suhareka. Oral clinical examination and self administered questionnaire were used to collect information about dental caries and its correlation to soft drinks and food habits. Examination was done between May and October in the year 2023. Impact of soft drink in caries was assessed through DMFT index and frequency of consumption of soft drinks. The data were collected statistically using SPSS version 26 and presented in tables and graphs. Results: The highest result of DMFT (4.36) with standard deviation 1.23 was noted in the group consuming more than 16 cans per week also the highest score in adolescent compared to frequency of consumed cans per week. Soft drinks found in Kosovo’s mar-kets are acidic with low pH, 93.75% of them had a pH below 4 which are considered erosive and only 6.25% are minimally erosive with a pH > 4, in terms of buffer capacity soft drinks can be ordered like this energy drinks >soda >100% fruit juice > fruit drinks. Improper tooth-brushing, dental visits only in case of pain and not preventive visits were significantly related to dental caries. Conclusion: The results of the research awarned us for high frequency consumption of soft drinks related to dental caries. It is recommended to be aware of the use of soft drinks, regular visits to the doctor, higher maintenance of oral health by using paste with sufficient fluoride content also brushing teeth 1 hour after consuming acidic food.

Preprint ARTICLE | doi:10.20944/preprints201607.0051.v1

Search for QPOs in the Light Curve of the Blazar OJ287: Preliminary Results from 2015/16 Observing Campaign

S. Zola, M. Valtonen, G. Bhatta, A. Goyal, B. Debski, A. Baran, J. Krzesinski, M. Siwak, S. Ciprini, A. Gopakumar, H. Jermak, K. Nilsson, D. Reichart, K. Matsumoto, K. Sadakane, K. Gazeas, M. Kidger, V. Piirola, F. Alicavus, K.S. Baliyan, A. Berdyugin, D. Boyd, M. Campas Torrent, F. Campos, J. Carrillo Gomez, D.B. Caton, V. Chavushyan, J. Dalessio, D. Dimitrov, M. Drozdz, A. Erdem, A. Escartin Perez, V. Fallah Ramazani, A.V. Filippenko, F. Garcia, F. Gomez Pinilla, M. Gopinathan, J.B. Haislip, J. Harmanen, G. Hurst, K.M. Ivarsen, M. Jelinek, A. Joshi, M. Kagitani, N. Kaur, N. Karaman, W.C. Keel, A.P. LaCluyze, B.C. Lee, E. Lindfors, J. Lozano De Haro, J.P. Moore, R. Naves Nogues, A.W. Neely, R.H. Nelson, W. Ogloza, S. Okano, J.C. Pandey, M. Perri, P. Pihajoki, G. Poyner, J. Provencal, T. Pursimo, A. Raj, R. Reinthal, S. Sadegi, T. Sakanoi, J.-L. Salto Gonzales, T. Schweyer, F.C. Soldan Alfaro, E. Sonbas, I. Steele, J.T. Stocke, J. Strobl, L.O. Takalo, T. Tomov, L. Tremosa Espasa, J.R. Valdes, J. Valero Perez, F. Verrecchia, J.R. Webb, M. Yoneda, M. Zejmo, W. Zheng, J. Telting, J. Saario, T. Reynolds, A. Kvammen, E. Gafton, R. Karjalainen, P. Blay

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies: active; BL Lacertae objects: individual (OJ 287); super massive black holes

Online: 18 July 2016 (10:46:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1008.v1

Comparison of Optogalvanic and Laser-Induced Fluorescence Spectroscopy

Laurentius Windholz

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: Lanthanide spectroscopy; Optogalvanic detection; Laser-induced fluorescence detection

Online: 19 February 2024 (07:46:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0034.v1

Simultaneous Quantification of 16 Bisphenol Analogues in Food Matrices

Fiorella Lucarini, Rocco Gasco, Davide Staedler

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: bisphenol analogues; canned foods; food matrices; QuEChERS; GC-MS; LC-MS/MS; endocrine disruptors

Online: 3 July 2023 (09:35:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1136.v1

Mismatch Responses to Speech Contrasts in Preschoolers With and Without DLD

Ana Campos, Jyrki Tuomainen, Outi Tuomainen

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: DLD; multifeature paradigm; mismatch response; ERPMMR time-frequency analysis

Online: 17 November 2023 (04:36:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0154.v1

MgAl Oxide Coatings Modified with CeO2 Particles Formed by Plasma Electrolytic Oxidation of AZ31 Magnesium Alloy: Photoluminescent and Photocatalytic Properties

Stevan Stojadinović, Nenad Radić

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: plasma electrolytic oxidation; photocatalysis; photoluminescence, MgO, MgAl2O4, methyl orange

Online: 6 March 2024 (04:01:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1275.v1

Numerical Algorithms for Divergence-Free Velocity Applications

Giacomo Barbi, Antonio Cervone, Sandro Manservisi

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: divergence-free velocity; Raviart-Thomas finite elements; mass conservation

Online: 16 July 2024 (10:15:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.2061.v1

Combining Translation Readthrough Inducing Drugs and Nonsense Mediated Decay Pathway Inhibition to Rescue of CFTRW1282X in Cystic Fibrosis Cell Model System

Roberta Bongiorno, Emanuele Vitale, Davide Ricci, Pietro Salvatore Carollo, Ivana Pibiri, Raffaella Melfi, Andrea Pace, Laura Lentini

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: premature termination codon; nonsense mutation; Nonsense-mediated decay; translational readthrough inducing drugs; oxadiazoles.

Online: 29 June 2024 (00:09:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1944.v1

miR-10a/b-5p-NCOR2 Regulates Insulin-Resistant Diabetes in Female Mice

Se Eun Ha, Rajan Singh, Byungchang Jin, Gain Baek, Brian G. Jorgensen, Hannah Zogg, Sushmita Debnath, Hahn Sung Park, Hayeong Cho, Claudia Marie Watkins, Sumin Cho, Min-Seob Kim, Moon Young Lee, Tae Yang Yu, Jin Woo Jeong, Seungil Ro

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: MicroRNAs; diabetes mellitus; estrogen; pancreatic β -cells

Online: 27 August 2024 (18:40:19 CEST)

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Working Paper REVIEW

Inducible Intracellular Membranes: Molecular Aspects and Emerging Applications

Jorge Royes Mir, Valérie Biou, Nathalie Dautin, Christophe Tribet, Bruno Miroux

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: membrane remodeling; membrane biosynthesis; membrane curvature; phospholipids; inner membrane; lipid biosynthesis

Online: 25 August 2020 (10:03:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1198.v1

Tuberculous Pleural Effusion-Derived Exosomal miR-130-3p and miR-423-5p Promote the Proliferation of Lung Cancer Cells via Cyclin D1

Hyun-Jung Kang, Sangho Yun, Seung-Ho Shin, Dong Hyuk Youn, Ga-Hyun Son, Jae Jun Lee, Ji Young Hong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: tuberculosis; lung cancer; exosome; intercellular communication

Online: 16 August 2024 (04:44:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0247.v1

Blocking and Deblocking of Diisocyanate to Synthesize Polyurethanes

Sourita Jana, Debasis Samanta, Mir Muhammad Fahad, Sellamuthu N Jaisankar, Hongdoo Kim

Subject: Chemistry And Materials Science, Biomaterials Keywords: Toluene diisocyanate; 3-(4-bromophenyl)-1H-pyrazole; blocking agent; blocked adduct; deblocks; polyol; polyurethane; coatings.

Online: 12 July 2021 (11:45:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0074.v1

miR-30a as Potential Therapeutic by Targeting TET1 through Regulation of the Hydroxymethlation of Drp-1 Promoter in IPF

Songzi Zhang, Huizhu Liu, Yuxia Liu, Jie Zhang, Hongbo Li, Weili Liu, Guohong Cao, Pan Xu, Jinjin Zhang, Changjun Lv, Xiaodong Song

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: idiopathic pulmonary fibrosis; miR-30a; TET1; Drp-1

Online: 16 January 2017 (04:44:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0308.v1

All Things Being Equal: Spatiotemporal Differences between Open and Women’s 16-Goal Polo

Russ Best, Regan Standing

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: horse; equine; Polo; GPS; horse welfare

Online: 29 August 2019 (08:37:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0129.v1

Extraction and Purification of Catechins from Tea Leaves: An Overview of Methods, Advantages, and Disadvantages

Oana Cioanca, Ionut-Iulian Lungu, Ioana Mita-Baciu, Silvia Robu, Ana Flavia Burlec, Monica Hancianu, Florina Crivoi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: catechins; HPLC; extraction methods; purification; tea polyphenols

Online: 2 April 2024 (07:40:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1357.v1

Where Are Planar 0-Vertex Graphs Hiding?

jan turulski

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: chemical graph; planar graph; Euler's formula; invariant states

Online: 19 August 2024 (14:02:09 CEST)

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Working Paper ARTICLE

Comparative Analysis of Software Defect PredictionTechniques

Mehreen Sirshar, Hira Mir, Khadija Amir, Laraib Zainab

Subject: Engineering, Automotive Engineering Keywords: software defect prediction; machine learning approach; integrated approach; Deep Forest

Online: 6 December 2019 (04:25:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0540.v1

Antibacterial and Antibiofilm Activities of Β –Lapachone by Modulating the Catalase Enzyme

Mushtaq Ahmad Mir, Sumaya Ahmed Altuhami, Sukanta Mondal, Nasreena Bashir, Ayed Dera

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: β -Lapachone; Bactericidal; Biofilms; Resistant; Zone of inhibition; Antimicrobial activity

Online: 30 January 2023 (06:10:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202011.0019.v1

Semelparity and Reproductive Death in Caenorhabditis elegans

David Gems, Carina Kern, Joseph Nour, Marina Ezcurra

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; biomass conversion; C. elegans; reproductive death; semelparity; senescent pathology

Online: 2 November 2020 (10:45:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1732.v1

Anti-Proliferative and Cytoprotective Activity of Ethylenediurea Derivatives with Alkyl and Oxygen-containing Groups as Substituents

Maxim S. Oshchepkov, Leonid Kovalenko, Antonida Kalistratova, Galina Sherstyanykh, Evgenia Gorbacheva, Alexey Antonov, Karina Ustinova, Nisreen Khadour, and Mikhail Akimov

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: carbamates; oxamates; synthetic cytokinins; substituted ureas; anti-oxidative effect; cytotoxicity; oxidative stress

Online: 27 May 2024 (10:27:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0742.v1

A Network Comprised of miR-15b and miR-29a is Involved in VEGFA Pathway Regulation in Thymus Adipose Tissue from Elderly Ischemic Cardiomyopathy Subjects

Adriana-Mariel Gentile, Said Lhamyani, Maria Mengual Mesa, Francisco Javier Pavón-Morón, John R Pearson, Julian Salas, Mercedes Clemente-Postigo, Lucia Perez Costillas, Gabriel Olveira, Rajaa El Bekay

Subject: Biology And Life Sciences, Aging Keywords: aging; angiogenesis; elderly; ischemia; microRNA; myocardial infarction; thymus adipose tissue; subcutaneous adipose tissue

Online: 12 September 2023 (07:09:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0304.v1

Aberrant Activation of hsa-miR-181d/STAT3 and hsa-miR-181d/5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted GBM

Heng-Wei Liu, Peter Mingjui Lee, Oluwaseun Adebayo Bamodu, Yu-Kai Su, Iat-Hang Fong, Chi-Tai Yeh, Ming-Hsien Chien, I-Hung Kan, Chien-Min Lin

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: glioblastoma; GBM; glioma; STAT3; STAT5A; hsa-miR-181d; microRNA

Online: 29 August 2019 (05:22:29 CEST)

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Background: Glioblastoma (GBM), a malignant grade IV tumor, is the most malignant brain tumor due to its hyper-proliferative and apoptosis-evading characteristics. The signal transducer and activators of transcription (STAT) family genes, including STAT3 and STAT5A, have been indicated to play important roles in GBM progression. Increasing number of reports suggest that Garcinol, a polyisoprenylated benzophenone and major bioactive component of Garcinia indica contains potent anti-cancer activities. Material & Methods: The present study investigated the anti-GBM effects of garcinol, focusing on the STAT3/STAT5A activation, using a combination of bioinformatics, in vitro, and ex vivo assays. Results: Our bioinformatics analysis of TCGA - GBM cohort (n=173) showed that STAT3 and STAT5A are preferentially elevated in primary and recurrent GBM, compared to non-tumor brain tissues, and is significantly correlated with reduced overall survival. In support, our immunohistochemical staining of a GBM cohort (n=30) showed an estimated 5.3-fold (p<0.001) elevation in STAT3 and STAT5A protein expression in primary and recurrent GBM versus the non-tumor group. In vitro, garcinol treatment significantly suppressed the proliferative, invasive, and migratory potential of U87MG or GBM8401 cells, dose-dependently. In addition, garcinol anticancer effect significantly attenuated the GBM stem cell-like phenotypes, as reflected by diminished ability of U87MG or GBM8401 to form colonies and tumorspheres and suppressed expression of OCT4 and SOX2. Furthermore, analysis on GBM transcriptome revealed an inverse correlation between the level of STAT3/5A and hsa-miR-181d. Garcinol-mediated anti-GBM effects were associated with an increased hsa-miR-181d/STAT3 and hsa-miR-181d/5A ratio. Conclusion: We present evidence of anti-GBM efficacy of garcinol mediated by enhancing the hsa-miR-181d/STAT3 and hsa-miR-181d/5A ratios in GBM cells. Our findings suggest a potential new therapeutic agent for combating aggressive GBM.

Preprint ARTICLE | doi:10.20944/preprints202306.2216.v1

Hypofractionated Post-Prostatectomy Radiotherapy in 16 Fractions: A Single Institution Outcome

Pavol Dubinsky, Vladimir Vojtek, Katarina Belanova, Natalia Janickova, Noemi Balazova, Zuzana Tomkova

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: prostate cancer, moderate hypofractionation, post-prostatectomy radiotherapy

Online: 30 June 2023 (10:30:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2527.v1

Updated Risk Assessment of Cannabidiol in Foods based on Benchmark Dose-Response Modeling

Eva Wisotzki, Heike Franke, Constanze Sproll, Stephan G. Walch, Dirk W. Lachenmeier

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: cannabidiol; novel food; health-based guidance value; benchmark dose; risk assessment

Online: 31 July 2024 (09:50:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1566.v1

Modulation of miR-29a and miR-29b Expression by an Oral Nutritional Supplement Similar to the Mediterranean Diet Pattern with Probiotics in Malnourished Hemodialysis Patients

Corina Verónica Sasso, Said Lhamyani, Francisco Hevilla, Marina Padial, María Blanca, Guillermina Barril, Tamara Jiménez-Salcedo, Enrique Sanz Martínez, Ángel Nogueira, Ana María Lago-Sampedro, Gabriel Olveira

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic kidney disease; oral nutritional supplement; malnutrition; hemodialysis; probiotics; circulating miRNAs; gene expression; inflammation; renal fibrosis

Online: 20 December 2023 (13:46:40 CET)

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Malnutrition is prevalent in patients with chronic kidney disease (CKD), especially those on hemodialysis. Recently, our group described that a new oral nutritional supplement (ONS) for malnourished (or at-risk) hemodialysis patients with a "similar to the Mediterranean diet" model, improved caloric and protein intake, nutritional status and inflammation and oxidation biomarkers. Our aim in this study was to evaluate whether the new ONS, including probiotics, may produce changes in miRNAs expression and its target genes in malnourished hemodialysis patients, compared to individualized diet recommendations. We conducted a randomized, multicenter, parallel-group study in malnourished hemodialysis patients divided in 3 groups (1: Control -C- individualized diet 2: Oral nutritional supplement -ONS- + placebo -ONS-PL- and 3: ONS + probiotics -ONS-PR). Study registration: NCT03924089. The trial was open to the ONS diet or individual dietary advice, but double-blind for the intake of probiotics supplements. MiRNAs and gene expression levels were analyzed by RT-qPCR at baseline and after 3 and 6 months. We observed that the expression of miR-29a and miR-29b increased significantly in patients with ONS-PR at 3 months in comparison with baseline, stabilizing at the sixth month. Moreover, we observed differences between studied groups, where miR-29b expression levels were elevated in patients receiving ONS-PR compared to the control group in the third month. Regarding the gene expression levels, we observed a decrease in the ONS-PR group compared to the control group in the third month for RUNX2 and TNFα. TGFB1 expression was decreased in the ONS-PR group compared to baseline in the third month. PTEN gene expression was significantly elevated in the ONS-PR group at 3-months in comparison with baseline. LEPTIN expression was significantly increased in ONS-PL group at 3-month intervention compared to baseline. The new Oral Nutritional Supplement associated with probiotics; increases the expression levels of miR-29a and miR-29b after 3 months of intervention, modifying the expression of target genes with anti-inflammatory and anti-fibrotic actions. This study highlights the potential benefit of this Oral Nutritional Supplement, especially associated with probiotics, in malnourished patients with chronic renal disease on hemodialysis.

Preprint ARTICLE | doi:10.20944/preprints202404.0503.v1

Formulation and Evaluation of Hydrophilic Matrix Tablets for Controlled Released Chlorzoxazone Delivery

Andreea Creteanu, Gabriela Lisa, Cornelia Vasile, Maria-Cristina Popescu, Daniela Pamfil, Claudiu N. Lungu, Gladiola Tantaru, Alina Diana Panaite

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: chlorzoxazone; collided; chitosan; matrix tablets; controlled release

Online: 8 April 2024 (07:15:31 CEST)

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The release of the active substance from the matrix modified-release tablets based on Kollidon®SR and chitosan depends on its solubility in the dissolution medium and on the composition of the matrix-forming polymers. The study is based on new oral matrix tablets based on Kollidon®SR and chitosan, formulated to optimize the low oral bioavailability of chlorzoxazone, a non-steroidal anti-inflammatory drug, a class II Biopharmaceutical Classification System. Nine types of chlorzoxazone matrix tablets were obtained using the direct compression method, and their combination at 1:1, 1:2, 1:3 chlorzoxazone/ excipients, 20%-40% (w/w) Kollidon®SR, 3-7% (w/w) chitosan and the auxiliary substances were formulated in constant concentrations. Pharmaco-technical characterization included the analysis of flowability and compressibility properties (flow time, friction coefficient, angle of repose, Hausner ratio, Carr Index), and of pharmaco-chemical characteristics (mass and dose uniformity, thickness, diameter, mechanical strength, Friability, degree of softening, in vitro release profile) of the tablets. Based on the initial evaluation of the pharmaco-technical analysis, pharmaco-chemical characteristics, and in vitro release profile, only three matrix tablet formulations (F1b, F2b, and F3b) were further tested. They were evaluated through Fourier-transform infrared spectrometry, X-ray Diffraction, thermogravimetry, differential scanning calorimetry, and in vitro dissolution tests. The three formulations were comparatively studied regarding the release kinetics of active substances using in vitro release testing. The results were analyzed by fitting into four representative mathematical models for the modified release oral formulations. In vitro kinetic study reveals a complex mechanism of release occurring in the first (0 - 2 hours) and second (2.0 hours – 36 hours) steps of drug release. Two factors have been calculated to assess the release profile of chlorzoxazone: f1 - the similarity factor and f2 - the factor difference. The results have shown that both Kollidon®SR and chitosan may be used as matrix-forming agents when combined with chlorzoxazone. In vitro dissolution tests revealed the F2b sample, data suggesting a faster drug release. The three formulations showed optimum pharmaco-technical properties and in vitro kinetic study, and they had tremendous potential to be used in oral pharmaceutical products for the controlled delivery of chlorzoxazone.

Preprint ARTICLE | doi:10.20944/preprints202402.1081.v1

A Comparative Study on Glass, Carbon and Steel Fiber

Omar Shahid Khan, Samiullah Sohu, Mir Zafarullah Jamali, Shakeel Ahmed, Sasitharan Nangapan

Subject: Engineering, Civil Engineering Keywords: Concrete; construction; compressive strength; carbon fibers; steel fibers; glass fibers

Online: 20 February 2024 (11:25:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.2064.v1

A Robust Flexible Model for Satellite Equipment Layout Optimisation

Masoud Hekmatfar, Mohammad Reza Mohammad Aliha, Mir saman Pishvaee, Tomasz Sadowski

Subject: Engineering, Aerospace Engineering Keywords: Satellite components/equipment 3D Layout; Uncertainty; Proposed Robust Flexible Programming Model (RFPM); Optimization Algorithm

Online: 31 October 2023 (12:13:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0983.v1

Brain Tumor Detection using the VGG-16 Model: A Deep Learning Approach

Dheiver Santos

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: brain tumor detection; VGG-16 model; convolutional neural network; MRI imaging; deep learning

Online: 14 August 2023 (08:34:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1002.v1

Retrieval of the Crop Canopy Chlorophyll: Machine Learning vs. Radiative Transfer Model

Mir Md Tasnim Alam, Anita Simic Milas, Mateo Gašparović, Henry Poku Osei

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: ; hybrid model; radiative transfer model; machine learning; data fusion; multispectral sensors; unmanned aerial vehicle ;

Online: 15 May 2024 (08:27:20 CEST)

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In recent years, the utilization of machine learning algorithms and advancements in Unmanned Aerial Vehicle (UAV) technology have marked significant shifts in remote sensing practices. In particular, the integration of machine learning with physical models and their application in UAV-satellite data fusion have emerged as two prominent approaches for estimating vegetation biochemistry. This study evaluates the performance of five machine learning regression algorithms (MLRAs) for mapping crop canopy chlorophyll at the Kellogg Biological Station (KBS) in Michigan, USA, across three scenarios: (1) application to Landsat 7, RapidEye, and PlanetScope satellite images; (2) application to UAV-satellite data fusion; and (3) integration with the PROSAIL radiative transfer model (hybrid methods PROSAIL + MLRAs). The results indicate that the majority of the five MLRAs utilized in UAV-satellite data fusion perform better than the five PROSAIL + MLRAs. The general trend suggests that the integration of satellite data with UAV-derived information, including the normalized difference red-edge index (NDRE), canopy height model, and leaf area index (LAI), significantly enhances the performance of MLRAs. The UAV-RapidEye dataset exhibits the highest coefficient of determination (R2) and the lowest root-mean-square errors (RMSE) when employing kernel ridge regression (KRR) and Gaussian processes regression (GPR) (R2 = 0.89 and 0.89 and RMSE = 8.99 µg/cm2 and 9.65 µg/cm2, respectively). Similar performance is closely observed for the UAV-Landsat and UAV-PlanetScope datasets (R2 = 0.86 and 0.87 for KRR, respectively). For the hybrid models, maximum performance is attained with Landsat data using KRR and GPR (R2 = 0.77 and 0.51 and RMSE = 33.10 µg/cm2 and 42.91 µg/cm2, respectively), followed by R2 = 0.75 and RMSE = 39.78 µg/cm2 for PlanetScope data upon integrating partial least squares regression (PLSR) into the hybrid model. Across all hybrid models, RapidEye data yielded the most stable performance, with R2 ranging from 0.45 to 0.71 and RMSE ranging from 19.16 µg/cm2 to 33.07 µg/cm2. The study highlights the importance of synergizing UAV and satellite data which enables effective monitoring of canopy chlorophyll in small agricultural lands.

Preprint ARTICLE | doi:10.20944/preprints202208.0276.v1

Determinants of Mental Health during and after COVID-19 Lockdown among University Students in Malaysia

Shang Kuan Ng, Imtiyaz Ali Mir, Muhammad Noh Zulfikri Mohd Jamali, Mohammed AbdulRazzaq Jabbar, Syeda Humayra

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19 lockdown; anxiety; depression; family income; physical activity

Online: 16 August 2022 (03:59:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0593.v1

Effectiveness of Atezolizumab in Metastatic Large Cell Neuroendocrine Carcinoma of the Lung and the Predictive Value of miR-375. The LANCE Trial, a Pilot Study

Georgios Evangelou, Ioannis P. Trontzas, Ioannis Gkiozos, Ioannis Vamvakaris, Maria Grammoustianou, Christina Paraskeva, Georgia Gomatou, Ioannis Tsamis, Ioannis A. Vathiotis, Maximilian Anagnostakis, Vasiliki Koliaraki, Konstantinos Syrigos

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: large cell neuroendocrine carcinoma; LCNEC; immunotherapy; atezolizumab; miR375

Online: 11 March 2024 (17:49:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0120.v1

β-Glucans and Post Prandial Satiety: The Role of Intestinal Hormones in Healthy Volunteers

Sara Baldassano, Silvio Buscemi, Anna Aiello, Giulia Accardi, Calogero Caruso, Sonya Vasto

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: β-glucans; entero-endocrine system; intestinal hormones; microbiota; nutritional intervention

Online: 23 December 2016 (13:37:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202003.0034.v1

MiR-144: A New Possible Therapeutic Target in Cancers

Omid Kooshkaki, Zohre Rezaei, Meysam Rahmati, Parviz Vahedi, Afshin Derakhshani, Oronzo Brunetti, Amir Baghbanzadeh, Behzad Mansoori, Nicola Silvestris, Behzad Baradaran

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer; microRNA; miR-144; Therapeutic target

Online: 3 March 2020 (11:05:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1611.v1

Evaluation of Galectin-3 in Dogs with Atrial Fibrillation

Giulia Arcuri, Carlotta Valente, Giovanni Romito, Federico Bonsembiante, Chiara Mazzoldi, Barbara Contiero, Helen Poser, Carlo Guglielmini

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: canine; biomarker; cardiac disease; echocardiography

Online: 20 July 2024 (11:47:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0030.v1

Allocation of Tutors and Study Centers in Distance Learning Using Geospatial Technologies

Shahid Nawaz Khan, Kamran Mir, Ali Tahir, Arshad Awan, Zaib un Nisa, Syeda Aareeba Gillani

Subject: Social Sciences, Education Keywords: geospatial technologies; distance learning; resource allocation; AIOU

Online: 3 April 2018 (04:29:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0174.v1

Synergizing Systems Thinking and Technology-Enhanced Learning Using the Flow Theory Framework

Brina Kurent, Stanislav Avsec

Subject: Social Sciences, Education Keywords: systems thinking; higher-order thinking; student engagement; technology-enhanced learning; flow; optimal experience; sustainable education

Online: 3 September 2024 (07:29:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0456.v2

Quantitative Image Processing for Three-Dimensional Episcopic Images of Biological Structures: Current State and Future Directions

Natalie Aroha Holroyd, Claire Walsh, Lucie Gourmet, Simon Walker-Samuel

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: episcopic; imaging; microscopy; annotation; quantification

Online: 6 March 2023 (13:52:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0219.v1

Ancient Agricultural and Pastoral Landscapes on the South Side of Lake Issyk-Kul: Preliminary Surveys of the Juuku Valley and Lower Kizil Suu Valley, Archaeobotanical Results of Three Stratigraphic Profiles, and GIS Modeling of Iron Age in Lower Kizil Suu

Claudia . Chang, Sergeo Sergievich Ivanov, Perry Alan Tourtellotte, Robert N. Spengler III, Basira Mir-Makhamad, David Kramar

Subject: Arts And Humanities, Archaeology Keywords: archaeological landscapes; Iron Age; Medieval period; agriculture; pastoralism; vertical zonation, Issyk-Kul Lake; archaeobotany; GIS mapping

Online: 17 May 2022 (03:29:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1949.v1

Homocysteine Metabolites Impair the Phf8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of PHF8-targeting miR-22-3p and miR-1229-3p in Human Vascular Endothelial Cells

Łukasz Witucki, Hieronim Jakubowski

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: homocysteine thiolactone; N-homocysteinylated protein; microRNA; PHF8; mTOR; autophagy; endothelial cells

Online: 28 June 2023 (07:08:26 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202201.0341.v1

Future of Edge Computing for Real Time Devices in Internet of Things

Mir Hassan, Jincai Chen, Tariq Khan, Umer Zukaib, Shoaib Ali Mallah

Subject: Engineering, Control And Systems Engineering Keywords: Internet of Things; Sensors; Real-Time; Edge Computing

Online: 24 January 2022 (10:30:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0443.v1

miR-378d Regulates Polyploidization and Malignant Phenotype of Tumor Cells Through AKT and RhoA

Wei Wang, Jie Peng, Susu Shi, Juan Yu, Jianli Liu, Haixiang Wei, Haixia Song, Shaoqiang Wang, Daolu Guo, Zhejie Li, Shujin He, Lei Li, Hongyan Zhang, Zhizhen Yan, Ran Zhao, Yukun Liu, Yanrong Liu, Junjun Li, Renya Zhang

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: miR-378d; ESCC; AKT; RhoA; polyploidization

Online: 16 June 2021 (12:07:30 CEST)

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Working Paper ARTICLE

Inhalational Anesthetics Inhibit Neuroglioma Cell Proliferation and Migration via miR-138, -210 and -335

Masashi Ishikawa, Masae Iwasaki, Hailin Zhao, Junichi Saito, Cong Hu, Qizhe Sun, Atsuhiro Sakamoto, Daqing Ma

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: microRNA; sevoflurane; desflurane; hypoxia inducible factor-1α; matrix metalloproteinase 9; glioma

Online: 23 March 2021 (09:14:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1179.v1

Participation of Secondary School Learners Aged 14 to 16 Years in Organised Sport

Mohamed Ayyub Mia, Makhaya Malema, Lloyd Leach

Subject: Social Sciences, Education Keywords: Participation; secondary school learners; organised sport; adolescent; sport clubs

Online: 18 July 2023 (07:52:20 CEST)

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Background: In South Africa, a relatively small number of children and adolescents belong to sports clubs, and adolescent participation in organised sport has steadily declined, especially in recent years. Participation levels in organised sport has decreased during late childhood and, more increasingly, as adolescents grow older. Aim: Therefore, the aim of this study was to determine the participation of secondary school learners aged 14 to 16 years in organised sport. Methods: The study was a quantitative and descriptive, cross-sectional design. The study sample was 329 conveniently sampled secondary school learners, males, and females, aged 14 to 16 years from three state schools in Cape Town, Western Cape Province. A researcher-generated, self-administered questionnaire on organised sport participation was developed, piloted, and validated among 44 learners of similar background, who did not participate in the main study. The statistical software, SPSS version 27, was used to capture and analyse the research data. The level of statistical significance for the study was set at p < 0.05. Results: A total of 66.9% of participants in the study sample participated in organised sport. Low but significant correlations were reported between gender and participation in organised sport (r = 0.22; p < 0.001), gender and friend participation in organised sport (r = 0.24; p < 0.001), participants participation and sibling participation in organised sport (r = 0.23; p < 0.001), participants participation and friend participation in organised sport (r = 0.36; p < 0.001), and between participant participation and parental participation in organised sport (r = 0.17; p = 0.003). Conclusion: Adolescent participation in organised sport was lower in the present circumstances compared to participation in the past three years. Adolescent males had higher participation levels in organised sport compared to adolescent females. There is an urgent need for solutions to counteract the low levels of adolescent participation in organised sport, especially in adolescent females.

Preprint ARTICLE | doi:10.20944/preprints202405.0511.v1

Cooperative Decay of an Ensemble of Atoms in a One-Dimensional Chain with a Single Excitation

Nicola Piovella

Subject: Physical Sciences, Optics And Photonics Keywords: Superadiance; subradiance; Cooperative emission

Online: 8 May 2024 (16:00:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0842.v1

p53R248Q Induces Invasion and Migration Through Overexpression of miR-182-5p in Cancer

Tzitzijanik Madrigal, Daniel Ortega-Bernal, Luis A Herrera, Claudia Haydée González De La Rosa, Guadalupe Domínguez-Gómez, Elena Aréchaga-Ocampo, José Díaz-Chávez

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: miRNAs; Mutant p53; Gain of function; Cancer

Online: 12 July 2023 (12:10:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0548.v1

Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring KLF4 Expression

Choulong Lee, Sunghye Cho, Dongtak Jeong

Subject: Biology And Life Sciences, Life Sciences Keywords: Cardiac dysfunction; Hypertension; Cardiac hypertrophy; Cardiac fibrosis; miR-25; KLF4; Angiotensin II; Inflammation; SERCA2a

Online: 10 July 2023 (08:43:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0319.v1

Between Life and Death: Reducing Phototoxicity in Super-Resolution Microscopy

Kalina L. Tosheva, Yue Yuan, Pedro M. Pereira, Siân Culley, Ricardo Henriques

Subject: Biology And Life Sciences, Other Keywords: Phototoxicity, Photodamage, Super-Resolution Microscopy, Fluorescence

Online: 30 August 2019 (08:22:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0585.v1

A Novel Approach to Compute Discrete Nonlinear Single Unit Activity Features

Nikita Zakharov, Elena Belova, Anna Gamaleya, Alexey Tomskiy, Alexey Sedov

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Entropy; mutual information; single unit activity; basal ganglia; subthalamic nucleus; Parkinson’ s disease

Online: 9 September 2024 (09:04:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0252.v1

Vaginal Nanoformulations for the Management of Preterm Birth

Asad Mir, Ketan Patel, Richa V. Vartak, Steven M. Yellon, Sandra E. Reznik

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: vaginal administration; preterm birth; progesterone; cervical ripening; uterine first-pass effect; vaginal nanoformulation

Online: 15 August 2022 (08:13:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0146.v1

Performance Analysis of Heterogeneous Networks in Presence of Deliberate Jammers Using Reverse Frequency Allocation

Muhammad Ihsan Ur Rehman, Muhammad Qasim, Abdul Wakeel, Mehmood Alam, Mir Yasir Umair

Subject: Engineering, Electrical And Electronic Engineering Keywords: Heterogeneous Cellular Networks; Deliberate Jamming; Inter-cell Interference; Independent Homogenous Poisson Point Process; Coverage Probability; Reverse Frequency Allocation

Online: 8 September 2021 (11:57:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1357.v1

Electrochemical DNA Biosensors with Dual Signal Amplification Strategy for Highly Sensitive HPV 16 Detection

Yuxing Yang, Yazhen Liao, Yang Qing, Haiyu Li, Jie Du

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Electrochemical Biosensor; High-risk human papillomavirus; Gold Nanoparticles; 3-Aminopropyltriethoxysilane

Online: 20 July 2023 (02:41:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0374.v1

Short hybrid floating-point formats based on 16-bit for FPGA-based arithmetic implementations

Mario Alfredo Ibarra-Carrillo, Herón Molina-Lozano, Jesús Yaljá Montiel-Pérez

Subject: Computer Science And Mathematics, Hardware And Architecture Keywords: Floating point, hybrid floating point, FPGA, numerical precision, accuracy, mixed-precision

Online: 6 July 2023 (07:54:48 CEST)

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