Search Results
32105 articles found
ARTICLE
|
doi:10.20944/preprints202004.0240.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
COVID19; 2019-nCov, 3CLpro inhbitors
Online: 15 April 2020 (10:00:52 CEST)
COMMUNICATION
|
doi:10.20944/preprints202004.0146.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Coronavirus Disease 2019; SARS-CoV-2; main protease; molecular docking-based virtual screening
Online: 9 April 2020 (09:34:45 CEST)
ARTICLE
|
doi:10.20944/preprints202006.0249.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
SARS-CoV-2; TMPRSS2; antibody epitopes; glycosylation sequons; heparin
Online: 21 June 2020 (10:12:34 CEST)
ARTICLE
|
doi:10.20944/preprints202002.0308.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
SARS-CoV-2; COVID-19; 3CL protease; molecular docking; molecular dynamics and simulations
Online: 23 February 2020 (02:17:46 CET)
ARTICLE
|
doi:10.20944/preprints202111.0125.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
artificial intelligence; de novo design; fragment-based drug discovery; HIV-1 inhibitors; pseudo natural products
Online: 8 November 2021 (09:23:49 CET)
ARTICLE
|
doi:10.20944/preprints202404.1825.v1
Subject:
Biochemistry And Molecular Biology,
Biology And Life Sciences
Keywords:
main protease (Mpro); ivermectin; nirmatrelvir; SARS-CoV-2; molecular docking; molecular dynamics
Online: 28 April 2024 (07:07:33 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1103.v1
Subject:
Engineering,
Bioengineering
Keywords:
mutate HIV protease inhibitors; carboxamides; heteroarenes; mammalian cells essay; ADME
Online: 16 May 2023 (05:32:28 CEST)
REVIEW
|
doi:10.20944/preprints201907.0286.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
HIV-1 Gag; Gag inhibitors; Protease; Protease inhibitors; drug resistance mutations; drug design
Online: 25 July 2019 (10:05:03 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0161.v2
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
COVID-19; docking; drug repurposing; natural products; in silico drug design; viral replication inhibition
Online: 1 June 2020 (02:42:54 CEST)
REVIEW
|
doi:10.20944/preprints202404.0944.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Immune checkpoint inhibitor; ipilimumab; pembrolizumab
Online: 16 April 2024 (03:30:17 CEST)
REVIEW
|
doi:10.20944/preprints202308.1518.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
SARS-CoV-2; main protease; inhibitors; molecular modeling; molecular dynamics simulations; binding energy calculation; ADME properties; potential therapeutics; drug discovery
Online: 22 August 2023 (07:19:37 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0102.v3
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Medicinal plants; Mpro; 3CLpro; spike (S) glycoprotein; COVID-19; SARS-CoV-2
Online: 1 July 2020 (08:37:49 CEST)
ARTICLE
|
doi:10.20944/preprints202003.0372.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
COVID-19; SARS-CoV-2; Marine natural product; Virtual screening; Docking
Online: 25 March 2020 (08:23:57 CET)
ARTICLE
|
doi:10.20944/preprints202004.0015.v2
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
virtual screening; COVID-19; Protease 3CL pro
Online: 3 April 2020 (15:08:50 CEST)
ARTICLE
|
doi:10.20944/preprints201905.0319.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
cyanobacteria; protease inhibitors; digestive enzyme; daphnia; HPLC; UV/Vis
Online: 27 May 2019 (12:56:49 CEST)
REVIEW
|
doi:10.20944/preprints202405.0326.v1
Subject:
Pharmacology And Toxicology,
Medicine And Pharmacology
Keywords:
SARS-CoV-2; 3CLpro; Novel Mechanism of Catalysis; FDA-approved drugs; Triad
Online: 7 May 2024 (16:44:24 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0149.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
COVID-19; SARS-CoV-2; Mpro; Molecular docking; MM-GBSA
Online: 9 April 2020 (11:05:55 CEST)
ARTICLE
|
doi:10.20944/preprints202003.0333.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
COVID-19; SARS-CoV-2; molecular docking; flavonoids
Online: 23 March 2020 (04:30:47 CET)
ARTICLE
|
doi:10.20944/preprints202003.0349.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
novel coronavirus; COVID-19; protease; molecular docking; drug designing; ADME; drug repurposing
Online: 23 March 2020 (09:47:49 CET)
REVIEW
|
doi:10.20944/preprints202402.0872.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Immunotherapy; Immune checkpoint inhibitors; Rechallenge therapy; Resistance; NSCLC
Online: 16 February 2024 (11:34:11 CET)
COMMUNICATION
|
doi:10.20944/preprints202311.0531.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Polydatin; HIV; Docking method; Swiss Dock Server
Online: 8 November 2023 (09:58:51 CET)
ARTICLE
|
doi:10.20944/preprints202403.0717.v1
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
Lumpy skin disease; DNA polymerase; potential inhibitors; phytocompounds; antiviral drug compounds; molecular docking
Online: 13 March 2024 (07:58:39 CET)
REVIEW
|
doi:10.20944/preprints202201.0468.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Flavivirus; NS2B-NS3; ZIKA Virus; Dengue Virus; West Nile Virus; Inhibitors
Online: 31 January 2022 (13:46:44 CET)
ARTICLE
|
doi:10.20944/preprints202402.1740.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Rheumatoid Arthritis, Anti-TNF, NRF2, Reverse Signaling, Biotherapy, Monoclonal Antibodies, Monocytes, Prediction.
Online: 29 February 2024 (14:46:26 CET)
REVIEW
|
doi:10.20944/preprints202404.0091.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
menin; menin inhibitors; leukemia; KMT2A; NPM1
Online: 2 April 2024 (02:51:43 CEST)
BRIEF REPORT
|
doi:10.20944/preprints202403.0928.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
systemic sclerosis; pulmonary hypertension; Phosphodiesterase-5 inhibitors; endothelin receptor antagonist
Online: 15 March 2024 (13:15:50 CET)
ARTICLE
|
doi:10.20944/preprints202403.1880.v1
Subject:
Public Health And Healthcare,
Other
Keywords:
Anti-interferon-γ autoantibodies; herpes zoster; monocyte chemoattractant protein-1; IFN-γ inducible protein-10; Janus kinas inhibitors; rheumatoid arthritis.
Online: 1 April 2024 (10:20:44 CEST)
REVIEW
|
doi:10.20944/preprints202402.1049.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
malignant pleural mesothelioma; immune checkpoint inhibitor; orphan drug; good clinical practice; Pharmaceuticals and Medical Devices Agency
Online: 20 February 2024 (04:03:22 CET)
ARTICLE
|
doi:10.20944/preprints202010.0346.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Trypanosoma cruzi; Presenilin; aspartic protease; SPOT-synthesis; anti-peptide antibodies; immunolocalization; transmembrane domains
Online: 16 October 2020 (12:01:25 CEST)
REVIEW
|
doi:10.20944/preprints202205.0290.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Cholesterol; PCSK9 inhibitors; HMG-CoA; LDL receptor; statins
Online: 23 May 2022 (10:01:24 CEST)
ARTICLE
|
doi:10.20944/preprints202404.1152.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Tuberculosis; nitrobenzamides; DprE; mycobacteria
Online: 17 April 2024 (11:50:50 CEST)
ARTICLE
|
doi:10.20944/preprints201609.0123.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
carbonic anhydrase; acetylcholinesterase; β-Lactam; 2-Azetidinone; enzyme inhibition; enzyme purification
Online: 30 September 2016 (05:38:45 CEST)
REVIEW
|
doi:10.20944/preprints202401.0310.v1
Subject:
Medicine And Pharmacology,
Dentistry And Oral Surgery
Keywords:
inflammation; inflammasome; inhibitors of the inflammasome; nanomaterials; functionalized biomaterials; periodontitis; general pathology
Online: 4 January 2024 (09:25:17 CET)
REVIEW
|
doi:10.20944/preprints202306.0441.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
anti-lipoxygenase peptide; bioactivity; enzymatic hydrolysis; food peptide; food protein; inflammation; lipoxidase; lipoxygenase inhibitory activity.
Online: 6 June 2023 (10:11:09 CEST)
ARTICLE
|
doi:10.20944/preprints202310.1571.v2
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Transketolase; malonylation; acetylation; sirtuin 5; oxythiamine; metformin; amprolium; thiamine; posttranslational modifications
Online: 10 November 2023 (12:03:31 CET)
REVIEW
|
doi:10.20944/preprints202405.0059.v1
Subject:
Dermatology,
Medicine And Pharmacology
Keywords:
atopic dermatitis; calcineurin; NFAT; tacrolimus; pimecrolimus; cyclosporine
Online: 1 May 2024 (07:49:16 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0329.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
SARS-CoV-2; COVID-19; protease; docking; pharmacophore; Zinc15
Online: 19 April 2020 (05:33:03 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0003.v2
Subject:
Biology And Life Sciences,
Virology
Keywords:
SARS-CoV-2; protease; virtual screening; pharmacophore; inhibitors; natural compounds
Online: 17 April 2020 (11:00:55 CEST)
COMMUNICATION
|
doi:10.20944/preprints202004.0062.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
COVID-19; FDA approved drugs; High Throughput Virtual Screening; Sincalide; Pentagastrin.
Online: 6 April 2020 (14:09:04 CEST)
ARTICLE
|
doi:10.20944/preprints201811.0550.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
poliovirus 2A protease (PV2Apro); expression; purification; MALDI-TOF; 3D structure
Online: 22 November 2018 (14:41:00 CET)
REVIEW
|
doi:10.20944/preprints202405.0668.v3
Subject:
Neuroscience And Neurology,
Biology And Life Sciences
Keywords:
epilepsy; neuroinflammation; NLRP3 inflammasome; epileptogenesis; antiseizure medication; interleukin-1b; caspase-1; ASC
Online: 31 May 2024 (15:29:49 CEST)
REVIEW
|
doi:10.20944/preprints202204.0202.v1
Subject:
Medicine And Pharmacology,
Endocrinology And Metabolism
Keywords:
Metabolic syndrome; SGLT2 inhibitors; Dapagliflozin; Empagliflozin; Canagliflozin; Translational modeling
Online: 21 April 2022 (10:12:04 CEST)
REVIEW
|
doi:10.20944/preprints202012.0167.v2
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Matrix metalloproteinase; MMPs; protease; TIMPs; exosite; small molecule inhibitors; monoclonal antibodies; proteomics; N-terminomics; TAILS
Online: 24 March 2021 (16:23:28 CET)
ARTICLE
|
doi:10.20944/preprints202401.0589.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Clavispora lusitaniae PC3; protease; solid- state fermentation; enzyme purification; gluten degradation
Online: 8 January 2024 (13:47:54 CET)
COMMUNICATION
|
doi:10.20944/preprints202010.0005.v1
Subject:
Medicine And Pharmacology,
Other
Keywords:
Enzymes, Peptide Hydrolases, Metalloproteases, Biomarkers, Gingival Crevicular Fluid, Atopic Dermatitis
Online: 1 October 2020 (08:55:12 CEST)
BRIEF REPORT
|
doi:10.20944/preprints202002.0242.v2
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
COVID-19; molecular docking; HIV protease inhibitor; nucleotide analogues
Online: 29 February 2020 (12:43:40 CET)
ARTICLE
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Pseudoalteromonas;proteases;hydrolysis;collagen;antioxidant peptides
Online: 24 July 2019 (11:56:00 CEST)
REVIEW
|
doi:10.20944/preprints202401.0803.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
CYP enzymes; CYP3A4; flavonoid; inhibition; natural products
Online: 10 January 2024 (10:24:39 CET)
ARTICLE
|
doi:10.20944/preprints202307.0031.v1
Subject:
Chemistry And Materials Science,
Applied Chemistry
Keywords:
Ionic Liquids; Corrosion Inhibitors; Bio-based
Online: 4 July 2023 (02:23:59 CEST)
ARTICLE
|
doi:10.20944/preprints201710.0143.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
cheminformatics; docking simulation; drug repositioning; thiopurine; tyrosinase
Online: 22 October 2017 (14:03:13 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0890.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Space Flight; Mast Cells; Tryptase; Chymase; Mongolian Gerbils; the Digestive System
Online: 11 August 2023 (04:54:59 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0231.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
G protein-coupled receptors, Protease Activated Receptor2; Allosteric modulator; 1-piperidinepropionic acid; Molecular Dynamics.
Online: 2 August 2023 (13:20:19 CEST)
REVIEW
|
doi:10.20944/preprints202302.0058.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
HIV-1 PR; host factors; host cell shut-off; protease; antiviral therapy; cell death; apoptosis
Online: 3 February 2023 (04:42:32 CET)
ARTICLE
|
doi:10.20944/preprints202208.0103.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Resveratrol; antioxidant metabolism; scavengome; biomimetic oxidation; bioactivity-guided isolation; NMR spectroscopy; xanthine oxidase
Online: 4 August 2022 (05:33:52 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0468.v1
Subject:
Animal Science, Veterinary Science And Zoology,
Biology And Life Sciences
Keywords:
African swine fever virus; pS273R; monoclonal antibody; epitope; diagnosis
Online: 10 June 2024 (04:04:51 CEST)
BRIEF REPORT
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
SARS-Cov-2; main protease; Spike protein; RIN
Online: 15 June 2020 (06:27:35 CEST)
ARTICLE
|
doi:10.20944/preprints201906.0088.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
ricin; marker peptides; unambiguous identification; mass spectrometry
Online: 11 June 2019 (08:27:32 CEST)
COMMUNICATION
|
doi:10.20944/preprints202402.0696.v1
Subject:
Public Health And Healthcare,
Other
Keywords:
HIV-1 protease 2; SWISS DOCK Server; Roussarcoma virus protease; Human Immunodeficiency Virus
Online: 13 February 2024 (08:13:13 CET)
REVIEW
|
doi:10.20944/preprints202205.0316.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
HIV; protease; CARD8; NNRTI; Inflammasome; Latent reservoir
Online: 24 May 2022 (03:54:52 CEST)
REVIEW
|
doi:10.20944/preprints202012.0419.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
immune checkpoint; lymphoid neoplasms; programmed death 1; cytotoxic T-lymphocyte antigen 4; monoclonal antibodies; combination therapies
Online: 17 December 2020 (08:10:05 CET)
CONCEPT PAPER
|
doi:10.20944/preprints202006.0206.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
serine protease; interferon; ribonucleoproteins; RNA binding proteins; SERPIN; A1AT; hemostasis rebalancing
Online: 17 June 2020 (03:20:54 CEST)
ARTICLE
|
doi:10.20944/preprints201703.0116.v1
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
In vivo; Alpha-glucosidase; Alpha-amylase; hyperglycemia
Online: 16 March 2017 (09:35:36 CET)
REVIEW
|
doi:10.20944/preprints202404.0176.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
histone deacetylase inhibitors; radiosensitisation; heterochromatin; double strand break; DNA repair
Online: 2 April 2024 (10:09:33 CEST)
REVIEW
|
doi:10.20944/preprints202308.1413.v1
Subject:
Medicine And Pharmacology,
Endocrinology And Metabolism
Keywords:
diabetes; cardiovascular; renal; SGLT1; SGLT2; therapy.
Online: 22 August 2023 (07:45:50 CEST)
REVIEW
|
doi:10.20944/preprints202307.1892.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Oncolytic virus; immune checkpoint inhibitors; immunotherapy
Online: 28 July 2023 (10:58:30 CEST)
ARTICLE
|
doi:10.20944/preprints202012.0383.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
meprin α; meprin β; zinc metalloproteinase; medicinal chemistry; probe development
Online: 15 December 2020 (12:56:31 CET)
ARTICLE
|
doi:10.20944/preprints202012.0354.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
meprin α; meprin β; zinc metalloproteinase; uHTS
Online: 14 December 2020 (16:36:57 CET)
HYPOTHESIS
|
doi:10.20944/preprints202004.0151.v2
Online: 22 April 2020 (09:46:54 CEST)
ARTICLE
|
doi:10.20944/preprints201910.0026.v2
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
ticks; Ixodes scapularis; blood digestion; serine proteases; trypsin
Online: 24 February 2020 (04:45:09 CET)
REVIEW
|
doi:10.20944/preprints202311.0295.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
Atrial fibrillation, SGLT2 inhibitors, cardiovascular outcomes, hemodynamic effects, AF risk reduction
Online: 6 November 2023 (08:13:49 CET)
ARTICLE
|
doi:10.20944/preprints202404.0785.v1
Subject:
Virology,
Biology And Life Sciences
Keywords:
enteroviruses, coxsackievirus, leucoverdazyls, antioxidant, antiviral, 2C protein
Online: 11 April 2024 (09:22:02 CEST)
REVIEW
|
doi:10.20944/preprints202401.1697.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
DOAC; FXIa; mAbs; ASO; drug-drug interactions
Online: 23 January 2024 (12:31:04 CET)
REVIEW
|
doi:10.20944/preprints202305.1761.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
checkpoint inhibitors; colitis; immune-related adverse events; enterocolitis; diarrhea
Online: 25 May 2023 (08:03:37 CEST)
ARTICLE
|
doi:10.20944/preprints202302.0423.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
B-cell; autoimmune disease; drug repurposing
Online: 24 February 2023 (09:11:37 CET)
REVIEW
|
doi:10.20944/preprints202402.1535.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
DNA polymerase I; Polymerase θ ; reverse transcriptase; homologous recombination; antibiotics; apicoplast
Online: 27 February 2024 (12:29:29 CET)
REVIEW
|
doi:10.20944/preprints202304.0516.v1
Subject:
Medicine And Pharmacology,
Internal Medicine
Keywords:
SGLT-2 Inhibitors; Inflammasome; NLRP3; reno-protective effects; Cardio-protective effects; neuro-protective effects.
Online: 18 April 2023 (10:33:39 CEST)
ARTICLE
|
doi:10.20944/preprints202211.0356.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Focal adhesion kinase; 3D-QSAR; Molecular Dynamics; MM-PB/GBSA; Free energy perturbation
Online: 18 November 2022 (10:13:00 CET)
ARTICLE
|
doi:10.20944/preprints202108.0001.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Antitumoral drug; Choline kinase inhibition; Choline uptake
Online: 2 August 2021 (08:42:22 CEST)
ARTICLE
|
doi:10.20944/preprints202312.1461.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
indirect comparison; Shiny method; reconstructed individual patient data; disease free survival; renal cell carcinoma; adjuvant setting
Online: 20 December 2023 (09:30:07 CET)
ARTICLE
|
doi:10.20944/preprints202004.0084.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
in silico repositioning; dual inhibitor; Covid-19; 3CLpro; PLpro; remdesivir
Online: 7 April 2020 (10:44:11 CEST)
ARTICLE
|
doi:10.20944/preprints202402.1288.v2
Subject:
Medicine And Pharmacology,
Endocrinology And Metabolism
Keywords:
SGLT2 Inhibitors; Empagliflozin; Renal fibrosis; Connective tissue growth factor; Epithelial-mesenchymal transition
Online: 23 February 2024 (13:25:01 CET)
ARTICLE
|
doi:10.20944/preprints202002.0047.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
2019-nCoV; therapeutic strategies; drug; ACE2
Online: 4 February 2020 (10:59:25 CET)
REVIEW
|
doi:10.20944/preprints201909.0140.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
hepatocellular carcinoma; immune checkpoint inhibitors; HCC; pembrolizumab; nivolumab; immune microenvironment; targeted therapies
Online: 14 September 2019 (18:37:29 CEST)
REVIEW
|
doi:10.20944/preprints201805.0145.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
carbonic anhydrase, enzyme inhibition, metalloenzymes, amino acid, glaucoma, tumors
Online: 9 May 2018 (13:55:15 CEST)
ARTICLE
|
doi:10.20944/preprints202311.0483.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
MRONJ; CDK4/6 inhibitors; metastatic breast cancer; oral epidemiology
Online: 8 November 2023 (08:42:55 CET)
ARTICLE
|
doi:10.20944/preprints202307.2034.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Bcl-2; Anti-apoptotic protein; Indole; Cancer drug discovery
Online: 28 July 2023 (14:36:37 CEST)
ARTICLE
|
doi:10.20944/preprints202107.0270.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
drug design; falcipain; malaria; peptidomimetics; Plasmodium falciparum; virtual screening; pharmacophore.
Online: 12 July 2021 (14:48:13 CEST)
REVIEW
|
doi:10.20944/preprints202106.0158.v1
Online: 7 June 2021 (09:29:06 CEST)
ARTICLE
|
doi:10.20944/preprints201811.0330.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
hyperpigmentation; tyrosinase inhibitors; 3-(2,4-dihydroxyphenyl)propionic acid; structure-activity relationship study; B16-F10 cellular melanogenesis inhibition
Online: 14 November 2018 (09:59:45 CET)
ARTICLE
|
doi:10.20944/preprints201801.0213.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
bichalcones; sirtuin inhibitors; virtual screening
Online: 23 January 2018 (09:12:43 CET)
REVIEW
|
doi:10.20944/preprints202311.0529.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
SARS-CoV-2; Papain-like protease; COVID-19; Molecular modelling; Molecular dynamics simulations; Drug discovery; Antiviral drugs; Inhibitors; Therapeutic agents; therapeutic targets; Irreversible inhibitors; Repurposing drugs
Online: 8 November 2023 (16:11:55 CET)
ARTICLE
|
doi:10.20944/preprints202203.0328.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Zika Virus; Flavonoids; Azadirachta indica; Molecular Docking; Molecular Dynamics Simulation; Binding free energy
Online: 24 March 2022 (09:31:59 CET)
ARTICLE
|
doi:10.20944/preprints202004.0068.v2
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
coronavirus; COVID-19; hACE-2; MPro; multi-target-directed ligand; protease inhibito; RdRp; SARS-CoV-2 virus
Online: 9 April 2020 (05:13:05 CEST)
ARTICLE
|
doi:10.20944/preprints202003.0226.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
COVID-2019; Mpro; 6LU7; medicinal plant compounds; docking
Online: 13 March 2020 (03:19:02 CET)
ARTICLE
|
doi:10.20944/preprints202001.0279.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
NS3 inhibitors; allosteric inhibitors; NS4A; peptidomimetics; imidazole; hepatitis C virus; molecular dynamics; Flaviviridae; DSLS; binding assay
Online: 24 January 2020 (11:11:46 CET)
ARTICLE
|
doi:10.20944/preprints202307.1251.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
ascorbic acid; pharmacologic ascorbate; pancreatic cancer; epigenetics; DNA methyltransferase (DNMT); ten-eleven translocation (TET) methylcytosine dioxygenase
Online: 18 July 2023 (13:51:14 CEST)
REVIEW
|
doi:10.20944/preprints202405.0992.v1
Subject:
Virology,
Biology And Life Sciences
Keywords:
proteases; viruses; respiratory proteases; protease inhibitors; SARS-CoV-2
Online: 15 May 2024 (10:29:30 CEST)
ARTICLE
|
doi:10.20944/preprints202404.1491.v1
Subject:
Virology,
Biology And Life Sciences
Keywords:
HIV-2; integrase strand transfer inhibitor (INSTIs); HIV; integrase; Lenacapavir; SARs-CoV-2
Online: 23 April 2024 (05:06:50 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0468.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
dasatinib; imatinib; nilotibin; ponatinib; children; therapeutic drug monitoring; sex and gender pharmacology; personalized medicine.
Online: 7 August 2023 (11:53:12 CEST)
REVIEW
|
doi:10.20944/preprints202305.1151.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
fusion proteins; inhibitor; therapeutic; cancer
Online: 16 May 2023 (10:32:09 CEST)