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Preprint ARTICLE | doi:10.20944/preprints202402.1647.v1

Study on the Mechanical and Aging Properties of an Antibacterial Composite Resin Loaded with Fluoride‐Doped Nano‐Zirconia Fillers

Liyuan Zheng, Yi Zhang, Yuming Bai, Qianju Wu

Subject: Public Health And Healthcare, Other Keywords: Composite resin; Nano-zirconia fillers; Fluoride-releasing; Antibacterial property; Aging test

Online: 29 February 2024 (08:09:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0301.v1

Resilience, Anger, and Insomnia in Nurses after the End of the Pandemic Crisis

Argyro Pachi, Aspasia Panagiotou, Nikolaos Soultanis, Maria Ivanidou, Maria Manta, Christos Sikaras, Ioannis Ilias, Athanasios Tselebis

Subject: Social Sciences, Psychology Keywords: insomnia; anger; resilience; post-pandemic; nursing workforce

Online: 4 September 2024 (12:09:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1975.v1

Biomarkers: The Key To Enhancing Dbs Treatment For Psychiatric Conditions

Guillermo Jose Bazarra Castro, Vicente Casitas, Carlos Martinez-Macho, Alejandra Madero Pohlen, Amelia Alvarez-Sala, Enrique Barbero Pablos, José Fernández Alén, Cristina V. Torres

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: Deep Brain Stimulation (DBS); Psychosurgery; Depression; Obsessive-Compulsive Disorder (OCT); Biomarkers; Diffusion tensor imaging (DTI)

Online: 25 September 2024 (12:46:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0706.v1

Innate and Adaptive Regulation of Cognition

Rodrick Wallace

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: n/a; cognition; control thory; Fisher Zero phase transition; hierarchy; information theory; pathology; statistical models

Online: 12 March 2024 (13:48:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.1667.v1

Antioxidant Effects of Aromatic Plant Extracts in Neurodegenerative Diseases: A Review

Youyang Zhu, Miao Tian, Yuliang Qin, Ting Zhao, Zhaofu Li, Dongdong Qin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurodegenerative diseases; Oxidative stress; Antioxidants; Aromatic plants extracts

Online: 20 September 2024 (20:20:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0604.v1

Wolfram Syndrome 1: A Neuropsychiatric Perspective on a Rare Disease

Valerio Caruso, Accursio Raia, Luciana Rigoli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Wolfram syndrome 1; WFS1 gene; neuropsichiatric disorders; new findings in Wolfram syndrome 1.

Online: 8 July 2024 (10:01:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0043.v1

Symptom Severity Changes in Obsessive-Compulsive Patients during COVID-19 Pandemic Are Associated with Shorter Illness Duration and Benzodiazepine Use: Possible Evolutionary Advantage of a Psychiatric Disorder

Giordano D’Urso, Alfonso Magliacano, Marco Manzo, Mattia Vittorio Pomes, Carla Iuliano, Felice Iasevoli, Bernardo Dell'Osso, Andrea De Bartolomeis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: obsessive-compulsive disorder; COVID-19; clinical evolution; adaptive psychopathology; illness duration; anxious diathesis

Online: 1 March 2024 (17:40:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.1322.v1

Clostridial Bovine Infections: A Review Focusing on Diseases in Brazil

Felipe Masiero Salvarani

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: botulism; tetanus; blackleg; malignant edema; enterotoxemia.

Online: 21 May 2024 (09:32:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1075.v4

Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus

Rima Obeid, Emmanuel Andrès, Richard Češka, Babak Hooshmand, Rosa-Maria Guéant-Rodriguez, Gabriel Ioan Prada, Jarosław Sławek, Latchezar Traykov, Binh Van Ta, Tamás Várkonyi, Karlheinz Reiners

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Diagnosis; neuropathy; cognitive decline; anemia; treatment; vitamin B12 deficiency

Online: 9 April 2024 (10:26:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0932.v1

Micro(nano)plastics and their potential impact on human gut health: a narrative review

Carlo Covello, Federica Di Vincenzo, Giovanni Cammarota, Marco Pizzoferrato

Subject: Biology And Life Sciences, Other Keywords: digestive system; gut microbiota; human cells; intestinal toxicity; microplastics; mouse models; nanoplastics; plastic; polymers

Online: 15 March 2024 (14:39:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0994.v1

The Curious Role of PAI‐1 in Severe OSA

Tea Friščić, Edvard Galić, Domagoj Vidović, Petrana Brečić, Igor Alfirević

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: plasminogen activator inhibitor-1; obstructive sleep apnea; continuous positive airway pressure; atherogenesis; fibrinolytic capacity

Online: 16 April 2024 (07:41:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1928.v1

Oxylipins in Aqueous Humor of Primary Open Angle Glaucoma Patients

Jianming Xu, Kewen Zhou, Changzhen Fu, Chong-Bo Chen, Yaru Sun, Xin Wen, Luxi Yang, Ng Tsz Kin, Qingping Liu, Mingzhi Zhang

Subject: Biology And Life Sciences, Life Sciences Keywords: primary open-angle glaucoma; aqueous humor; oxylipins; arachidonic acid

Online: 24 July 2024 (09:46:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1265.v1

The Influence of Gender on the Psychiatric Comorbidity of Treated Danish Patients With and Without Alcoholism

Elizabeth C Penick, Waheeda A. Hossain, Wendy Madarasz, Ann M Manzardo, Joachim Knop, Erik L Mortensen, William F Gabrielli

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Alcohol use disorder; Gender; Psychiatric comorbidity

Online: 19 April 2024 (09:56:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0555.v1

Assessment of Nutritional Status and Risk of Malnutrition Using Adapted Standard Tools in Patients with Mental Illness and in Need of Intensive Psychiatric Treatment

Ladina Risch, Florian Hotzy, Stefan Vetter, Sascha Hiller, Kathrin Wallimann, Erich Seifritz, Sonja Mötteli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: nutritional risk screening; severe mental illness; psychiatric treatment; BMI; nutritional status; malnutrition; depression; schizophrenia; nutrition; diet

Online: 30 November 2022 (02:44:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1142.v1

The Impact of Psychological Health on Childhood Obesity: A Cross-Developmental Stage Analysis

Georgios Feretzakis, Athanasia Harokopou, Olga Fafoula, Athina Balaska, Antriana Koulountzou, Efstathia Katoikou, Athanasios Anastasiou, Georgios Zagkavieros, Ilias Dalainas, Georgios Gkritzelas

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Childhood Obesity; Psychological Well-being; Bioinformatics; Developmental Stages; Emotional Regulation; Social Dynamics; Adaptive Strategies; Obesity Interventions; Public Health; Pediatric Healthcare

Online: 20 February 2024 (11:59:35 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202405.2169.v1

Neurological and Psychiatric Illness amongst Beggars: A Critical Appraisal of Indian Scienario

Souvik Dubey, Shambaditya Das, Ritwik Ghosh, Mahua Dubey, Alak Pandit

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Beggar; Neurological and psychiatric disease; social perspective; India

Online: 31 May 2024 (15:31:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1328.v1

Degnala in Buffaloes: A Review on a Neglected Disease?

André De Medeiros Costa Lins, Felipe Masiero Salvarani

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: rice straw; Fusarium spp.; mycotoxicosis; toxigenic fungi; buffaloes diseases

Online: 16 July 2024 (12:32:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0962.v1

Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Which Differences between Alcohol, Cannabis and Psychostimulants?

Martina Di Paolo, Antonia Calabrese, Guido Nosari, Valentina Ciappolino, Luisa Cirella, Alice Caldiroli, Enrico Capuzzi, Massimo Clerici, Massimiliano Buoli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: alcohol; cannabis; clinical variables; peripheral biomarkers; psychostimulants; substance-induced psychotic disorder

Online: 19 February 2024 (14:34:50 CET)

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Preprint REVIEW | doi:10.20944/preprints201906.0192.v1

Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders

Arturo Andrade, Ashton Brennecke, Shayna Mallat, Julian Brown, Juan Gomez-Rivadeneira, Natalie Czepiel, Laura Londrigan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: voltage-gated calcium channels; major depressive disorder; autism spectrum disorder; schizophrenia; bipolar disorder; attention-deficit and hyperactivity disorder; anxiety; calcium channel modulators; psychiatric disorders; auxiliary subunits; genetic risk variations

Online: 20 June 2019 (04:16:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0375.v1

Candidiasis in Choloepus sp. – a Review of New Advances on the Disease

Marina Sette Camara Benarrós, Felipe Masiero Salvarani

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Fungus; Real sloth; Gastrointestinal tract; Disease; Wild mammal

Online: 4 July 2024 (14:18:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.2051.v1

Sustainability of Municipal Wastewater Treatment

Jan Derco, Patrícia Guľašová, Maša Legan, Ronald Zakhar, Andreja Žgajnar Gotvajn

Subject: Engineering, Chemical Engineering Keywords: efficiency; emerging pollutants; energy savings; greenhouse emissions; macronutrients; microalgae; micropollutants; municipal wastewater treatment; sludge management; sustainability

Online: 28 August 2024 (11:44:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0564.v2

Possibility of Assessing Pain with Biomarkers in Psychiatric Disorders

Piotr Jakubow, Urszula Kosciuczuk, Adam Garkowski, Aleksander Turczynowicz, Małgorzata Mojsak, Łukasz Skoworński

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: psychiatric disorders; neuroimaging; biochemical; pain; pain biomarkers

Online: 21 June 2021 (16:39:16 CEST)

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According to the literature, patients with chronic pain and mental disorders constitute a huge, heterogeneous group. However, it is known that social and psychological processes closely affect the level and expression of chronic pain. In this paper, we present a review of the literature, define methods of identifying pain biomarkers and consider the possibility of using them to assess pain in mental disorders. Group researchers searched PubMed, Scope, and Cochrane databases for "pain biomarkers in mental disorders" between 2011 and 2021. for available databases for full-text, peer-reviewed studies and review publications using the following keywords: pain biomarkers, neuroimaging pain, pain metabolomics, pain and psychiatric disorders, pain electroencephalography (EEG), serum pain biomarkers, saliva biomarkers, and diagnosis pain. The search included full-text articles, clinical trials, randomized controlled trials, and systematic reviews. Was used part of the PRISMA method to review the literature systematically. A literature search identified 283 studies based on the initially set inclusion and exclusion criteria. In the subsequent selection stages, 11 studies were selected for analysis. There are three main areas of the possible use of biomarkers for the clinical assessment of pain in psychiatric patients, neuroimaging, changes in metabolite levels in body fluids, and changes in gene expression. As a result of the review, individual pain mediators were distinguished that may be markers of pain in psychiatric patients. Some mediators indicate the specificity of pain and are of diagnostic importance. However, despite significant advances in research, most of the described biomarkers found in clinical trials assessing the severity and frequency of pain have no practical significance in psychiatric disorders. It is possible to diagnose pain based on neuroimaging using various methods, genetic methods, body fluids: blood and urine. Of the many, body fluid biomarkers are the most advanced. Discussion: Biomarker research is a dynamically developing field. The review has proposed new ways to diagnose pain by identifying pain biomarkers. Work presented pain diagnostics in psychiatric disorders based on biomarkers from various neuroimaging methods, blood and urine analysis. The possibility of new, effective techniques gives hope for the correct diagnosis of pain, especially in patients with mental disorders, which would allow for appropriate and adequate therapeutic therapies. In clinical practice is limited to a few methods. Assessment of pain biomarkers in body fluids (serum, saliva, and urine) seems to be the most practical and promising method of clinical application. Conclusions: There are new techniques that give hope for the correct diagnosis of pain, especially in patients with mental disorders, which will allow for their proper and adequate therapy. According to the literature, patients with chronic pain and mental disorders constitute a huge, heterogeneous group. However, it is known that social and psychological processes closely affect the level and expression of chronic pain.

Working Paper REVIEW

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Simge Seren Kirlioglu, Yasin Hasan Balcioglu

Subject: Social Sciences, Behavior Sciences Keywords: biological clocks; circadian rhythm disorders; mental disorders; melatonin; HPA-axis

Online: 16 May 2020 (17:18:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0080.v1

Multivariate Analysis of Structural and Functional Neuroimaging Can Inform Psychiatric Differential Diagnosis

Drozdstoy Stoyanov, Sevdalina Kandilarova, Katrin Aryutova, Rositsa Paunova, Anna Todeva-Radneva, Adeliya Latypova, Ferath Kherif

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: multivariate linear method; validation; diagnosis; discriminative; signatures of disease; schizophrenia; depression

Online: 3 December 2020 (10:38:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1337.v1

Ana Pjevac, Teodora Safiye, Mirjana Jovanovic

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: internet addiction, adolescents, temperament, online, IAT, TEMPS

Online: 23 February 2024 (09:10:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1324.v1

Brief Cognitive Behavioral Therapy for Depression and Anxiety in Patients With Schizophrenia in Psychiatric Home Nursing Service: Pilot Randomized Controlled Trial

Masayuki Katsushima, Eiji Shimizu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; depression and anxiety; brief cognitive behavioral therapy; psychiatric home nursing; workbook

Online: 19 June 2024 (08:42:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0270.v1

Comparison of Model Systems for Emulating Human Tissue and Physiology in Psychiatric Research

Kai Cheng, Annie Kathuria, Anannya Kshirsagar, John Nixon, Jonathan Lau, Kun Yang, Akira Sawa

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Psychiatric Disorders; Diseases Modeling; Organoids; Stem Cells; Monolayer Culture

Online: 5 August 2024 (10:38:47 CEST)

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The modeling of psychiatric disorders poses significant challenges due to the complex nature of these conditions, which encompass a range of neuropsychiatric diseases such as autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar disorder (BD), post-traumatic stress disorder (PTSD), anxiety and depression. The rising global prevalence of mental disorders and the urgency for more effective treatments have propelled the development of innovative in vitro models. This review presents a thorough examination of two-dimensional (2D) versus three-dimensional (3D) induced pluripotent stem cell (iPSC) models of neuropsychiatric diseases, offering insights into their respective capacities to mimic neurodevelopment and cellular phenotypes observed in these conditions. Our comparative analysis reveals that while traditional 2D cultures have been instrumental in elucidating disease pathways and high-throughput drug screening, they fall short in replicating the intricate cellular architecture and environment of the human brain. On the other hand, 3D organoid models, including brain organoids, better recapitulate the spatial organization, cell-type diversity, and functional connectivity of brain tissue, offering a more physiologically relevant context for studying disease mechanisms and testing therapeutic interventions. We assess the progress in modeling ASD, Schizophrenia, Bipolar Disorder, PTSD, and depression, highlighting the advanced understanding of disease etiology and potential treatment avenues offered by 3D iPSC technologies. Challenges remain, including the scalability, reproducibility, and maturation of organoids, but the potential for personalized medicine and the elucidation of disease ontogeny is unparalleled. The review concludes with a perspective on the future directions of psychiatric disease modeling, emphasizing the integration of 3D iPSC models with high-throughput technologies and computational approaches to enhance our understanding and treatment of these debilitating conditions.

Preprint ARTICLE | doi:10.20944/preprints202407.0090.v1

Insights into Psychiatric Diseases Represented by Wave Equations: A Mathematical and Graphical Exploration

Richard Montgomery

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Keywords: Psychosis, Bipolar Disorder and Obsessive Compulsive Disorder, Simulation with waves and differential equations

Online: 1 July 2024 (13:13:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0259.v1

From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders

Masaru Tanaka, László Vécsei

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: psychosis; Parkinson's disease; antioxidants; genetic therapy; stroke; anxiety; migraine; epilepsy; aphasia; cardiovascular diseases; cognition

Online: 5 March 2024 (12:31:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2002.v1

Navigating the Complex Intersection of Substance Use and Psychiatric Disorders: A Comprehensive Review

Anees Bahji

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: comorbidity; substance use disorders; psychiatric disorders; treatment interventions; dual diagnosis

Online: 29 January 2024 (12:52:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0204.v1

Professional Quality of Life, Job Satisfaction, and Intention to Leave Among Psychiatric Nurses

Shaher Hamaideh, Abdallah Abu Khait, Hanan Al-Modallal, Rami Masa'deh, Ayman Hamdan-Mansour, Mohammed AlBashtawy

Subject: Public Health And Healthcare, Nursing Keywords: ProQoL; job satisfaction; intention to leave; psychiatric nurses; Jordan

Online: 5 December 2023 (04:46:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0951.v1

Sociodemographic and Clinical Correlates including Psychiatric Comorbidities in Clinical Population of Irritable Bowel Syndrome

Ankita Saroj, Adarsh Tripathi, Sumit Rungta, Sujita Kumar Kar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Irritable bowel Syndrome; Psychiatric comorbidities; Somatic symptoms; Anxiety; Stress

Online: 18 March 2024 (09:20:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0155.v1

Prevalence & Psychiatric Correlates of Illicit Substance Use in UK Undergraduate students

Holly Foster, Jodie Stevenson, Umair Akram

Subject: Social Sciences, Behavior Sciences Keywords: Sleep; Substance Use; Insomnia; Anxiety; Depression; Students; Stress

Online: 9 February 2023 (06:03:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0392.v1

Efficacy of Lasmiditan as a Secondary Treatment for Migraine Attacks After Unsuccessful Treatment with a Triptan

Yasushi Shibata, Hiroshige Sato, Akiko Sato, Youichi Ha

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: migraine; triptan; lasmiditan; step care

Online: 7 May 2024 (15:40:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1391.v1

Effect of Menthol Treatment on the Sprouting and Quality of Potato Tuber

Ye Xu, Yang Qin, Qianqian Hou, Defu Niu, Qingmin Chen

Subject: Biology And Life Sciences, Horticulture Keywords: ; potato tuber; menthol; sprouting inhibition; quality; glucoside alkaloids ;

Online: 22 April 2024 (10:20:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0114.v1

The Electronic Properties Evolution of Tellurium Crystals with Plasma Irradiation Treatment

Congzhi Bi, Tianyu Wu, Jingjing Shao, Pengtao Jing, Hai Xu, Jilian Xu, Wenxi Guo, Yufei Liu, Da Zhan

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: tellurium crystal flake; plasma irradiation; tunnelling current; conductive atomic force microscopy (CAFM); band gap

Online: 1 April 2024 (15:23:18 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202310.0800.v1

Emerging Translational Research in Neurological and Psychiatric Diseases: From In Vitro to In Vivo Models

Masaru Tanaka, Ágnes Szabó, László Vécsei, Lydia Giménez-Llort

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's disease; Parkinson's disease; multiple sclerosis; depressive disorder; anxiety disorder; bipolar disorder; electric stimulation; translational research

Online: 12 October 2023 (08:38:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0447.v1

Application of Mass Multivariate Analysis on Neuroimaging Data Sets in Psychiatric Diagnostics

Rositsa Paunova, Sevdalina Kandilarova, Anna Todeva-Radneva, Adeliya Latypova, Ferath Kherif, Drozdstoy Stoyanov

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mass multivariate analysis; neuroimaging, depression, schizophrenia

Online: 31 January 2022 (11:07:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.2018.v1

The Precision Medicine: Advancement and Transformation in Cancer Treatment

Samiksha Khobragade, Ujwal Vyas, Anil Pethe, Rahul G Ingle

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Cancer; CRISPR-Cas9; immunotherapy; precision medicine; next generation sequences

Online: 29 June 2024 (04:53:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0568.v1

Gender-Difference in Response to Treatment with Liraglutide 3.0 mg

Ilaria Milani, Gloria Guarisco, Marianna Chinucci, Chiara Gaita, Frida Leonetti, Danila Capoccia

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: ; Obesity; gender; GLP1-RAs; Liraglutide; weight loss ;

Online: 9 May 2024 (07:24:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0162.v1

Effectiveness of Smartphone App for the treatment of Pediatric Obesity: A Prospective Longitudinal Study

Giuseppina Rosaria Umano, Mariapia Masino, Grazia Cirillo, Giulia Rondinelli, Francesca Massa, Giuseppe Salvatore R.C. Mangoni di Santo Stefano, Anna Di Sessa, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Pietro Buono

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: obesity 1; treatment 2; m-Health 3

Online: 2 August 2024 (12:58:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0819.v1

Psychiatric Hospitalization for Psychopathological Disorders and Self-Injurious Behaviors in Italian Children and Adolescents during COVID-19

Maria Pontillo, Deny Menghini, Roberto Averna, Milena Labonia, Giulia Lazzaro, Maria Cristina Tata, Stefano Vicari

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19 pandemic; children; adolescents; psychiatric hospitalization; mood disorders; non-suicidal self-injurious behaviors; suicidal ideation

Online: 12 October 2023 (15:43:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0498.v1

Treatment of the Fractures of the Humeral Surgical Neck: MIROS versus Intramedullary Nailing. A Retrospective Study

Michelangelo Palco, Gabriele Giuca, Domenico Fenga, Ilaria Sanzarello, Matteo Nanni, Danilo Leonetti

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Proximal Humerus Fractures; MIROS System; Intramedullary Nailing; Orthopedics; Retrospective Study

Online: 6 September 2024 (09:42:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0370.v1

CCL11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-psychiatric Disorders

Mariya Ivanovska, Zakee Abdi, Marianna Murdjeva, Danielle Macedo, Annabel Maes, Michael Maes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: eotaxin; immune marker; neuroinflammation; ageing; neuro-psychiatric disorder

Online: 30 January 2020 (14:42:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1679.v1

Adenomyosis: A Call for Awareness, Early Detection and Effective Treatment Strategies

Georgios Kolovos, Ioannis Dedes, Sara Imboden, Michel Mueller

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: adenomyosis; reproductive health; early detection; minimal invasive therapy

Online: 27 May 2024 (07:12:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1530.v1

Mathematical Models for Removal of Pharmaceutical Pollutants in Rehabilitated Treatment Plants

Irina Meghea

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: mathematical model; Navier-Stokes equations; pharmaceutical pollutants; infiltration through membranes; flow through porous media; rehabilitation of existing cleaning plants

Online: 19 September 2024 (12:45:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0006.v1

The Role of Postbiotics in Allergic Asthma Treatment

Konstancja Maria Węgrzyn, Agnieszka Jasińska, Kamil Janeczek, Wojciech Feleszko

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: postbiotics; allergic asthma; microbiome; bacterial lysates; immunomodulation

Online: 1 July 2024 (09:18:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1713.v1

Mechanism and Synergy Effect of the Hybrid Water Disinfection Process Using Electric Discharges Combined with Chlorination

Antonina Malyushevskaya, Piotr Koszelnik, Olena Mitryasova, Anna Yushchishina, Andrii MATS, Dorota Papciak, Monika Magdalena Zdeb

Subject: Engineering, Electrical And Electronic Engineering Keywords: Keywords: water disinfection; underwater electrical discharges; cavitation; activation of liquid.

Online: 25 June 2024 (07:13:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0058.v1

Novel Treatment Modalities of Type 1 Diabetes Mellitus: Opportunities and Challenges

Rasha Aziz Attia Salama, MohamedAnas MohamedFaruk Patni, Shadha Nasser Mohammed Ba-Hutair, Nihal Amir Wadid, Mushirabanu Sharifmiyan Akikwala

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: type1 diabetes mellitus; mesenchymal stem cells; gene therapy; pancreatic islet cell transplantation; teplizumab

Online: 3 June 2024 (09:51:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0419.v1

Mechanisms of Resistance to Rituximab Used for the Treatment of Autoimmune Blistering Diseases

Liliana Gabriela Popa, Ioana Dumitras, Calin Giurcaneanu, Ovidiu Berghi, Diana Sabina Radaschin, Iolanda Vivisenco, Marius Nicolae Popescu, Cristina Beiu

Subject: Medicine And Pharmacology, Dermatology Keywords: autoimmune blistering diseases; pemphigus; rituximab; mechanism of action; resistance

Online: 8 August 2024 (16:17:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0131.v1

Salmonella Inactivation Model by UV-C Light Treatment in Chicken Breast

Rosa María García-Gimeno*, Guiomar Denisse Posada-Izquierdo, Eva Palomo-Manzano, Poliana Mendes de Souza

Subject: Public Health And Healthcare, Other Keywords: non-thermal treatment; UV-C; low transmittance food; mathematical modelling; foodborne pathogens

Online: 2 August 2024 (06:04:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2544.v1

Nano-Formulations of Natural Antioxidants for the Treatment of Liver Cancer

Mariateresa Cristani, Andrea Citarella, Federica Carnamucio, Nicola Micale

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: antioxidants; liver cancer; nano-formulations; drug delivery; natural compounds; hepatocellular carcinoma; oxidative stress

Online: 31 July 2024 (14:02:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.0976.v1

The Potential Influence of Residual or Recurrent Disease on Bevacizumab Treatment Efficacy in Ovarian Cancer

Klaudia Żak, Małgorzata Satora, Ilona Skrabalak, Rafał Tarkowski, Marta Ostrowska-Leśko, Marcin Bobiński

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bevacizumab; ovarian cancer; angiogenesis; VEGF

Online: 19 February 2024 (11:19:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0775.v1

Prevalence of and Gender Differences in Psychiatric Disorders among Juvenile Detainees in South Korea: A Comparative Study

Bum-Sung Choi, Bongseog Kim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Juvenile detainees; psychiatric disorder; conduct disorder

Online: 12 October 2023 (05:38:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0067.v1

Modeling Sound Propagation Using the Corrective Smoothed Particle Method with an Acoustic Boundary Treatment Technique

YongOu Zhang, Xu Li, Tao Zhang

Subject: Physical Sciences, Mathematical Physics Keywords: computational acoustics; meshfree method; Lagrangian approach; smoothed particle hydrodynamics; corrective smoothed particle method; boundary conditions; numerical method

Online: 13 January 2017 (10:09:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0448.v1

The Impact of Event Scale – Revised: Examining its cutoff scores among Arab psychiatric patients and healthy adults within the context of COVID-19 as a collective traumatic event

Amira M. Ali, Saeed Abdullah Al-Dossary, Abdulaziz Mofdy Almarwani, Maha Atout, Rasmieh Al-Amer, And Abdulmajeed A. Alkhamees

Subject: Social Sciences, Psychology Keywords: Impact of Event Scale-Revised (IES-R)/post-traumatic stress disorder (PTSD); cutoff point/cutoff score; psychiatric patients/the general public/healthy adults; psychometric evaluation/criterion validity; Coronavirus Disease-19/COVID-19; Arabic version/Arab/Saudi Arabia

Online: 25 January 2023 (05:02:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.1375.v1

Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease: Insights into Pathophysiology and Treatment

AMER ALKHALIFA, Oula Alkhalifa, Iva Durdanovic, Dalia R. Ibrahim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's disease; Oxidative stress; Mitochondrial dysfunction; Antioxidant; Reactive oxygen species.

Online: 19 August 2024 (16:45:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0662.v1

New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics

Yingyu Pan, Jianing Li, Zhengyang Fan, Yonghao Chen, Xiaoxuan Huang, Dong Wu

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic pancreatitis; probiotics; prebiotics; gut microbiota

Online: 12 August 2024 (03:05:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1091.v1

The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation

Bruno Roméo, Valentine Lestra, Catherine Martelli, Ammar Amirouche, Amine Benyamina, Nora Hamdani

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: inflammation; T. gondii; cannabis use; eosinophils counts

Online: 18 September 2023 (13:25:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0037.v1

The Plastic Adaptation to Pathology in Psychiatry. Are Patients with Psychiatric Disorders Pathological Experts?

Ali Amad, Paul Expert, Louis-David Lord, Thomas Fovet, Pierre A. Geoffroy

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: neuroplasticity; neuroprogression; psychiatric disorders; brain economy; severe mental illness; biomarkers

Online: 3 December 2018 (16:18:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1628.v1

The Impact of Combinated Process of Electrolysis and Activated Sludge Process on Municipal Wastewater Treatment

Miroslav Hutňan, Barbora Jankovičová, Ronald Zakhar, Nikola Šoltýsová

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: activated sludge process; denitrification; electrolysis; nitrification; sludge volume index (SVI)

Online: 27 March 2024 (06:26:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0138.v1

Fundamental Clock of Biological Aging: Convergence of Molecular, Neurodegenerative, Cognitive, and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology

Victor Vasilyevich Dyakin, Nika Victorovna Dyakina-Fagnano, Laura Beth McIntire, Vladimir Nikolaevich Uversky

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: spontaneous; non-enzymatic; post translational modifications; racemization; biological clock; natural selection; allostatic load; psychological aging; psychological stress; stress response sys-tem; phase transitions.

Online: 8 November 2021 (13:08:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.0230.v1

Magnesium Ion: A New Switch in Tumor Treatment

Leyi Huang, Renxi Lin, Jiaxi Chen, Yuanlin Qi, Ling Lin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Magnesium Ion; Mitochondria; Mitochondrial Function; Energy Metabolism; Cancer Therapy

Online: 6 May 2024 (05:45:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1578.v1

TransPerineal Laser Ablation (TPLA) Treatment of Focal Low-Intermediate Risk Prostate Cancer

Guglielmo Manenti, Tommaso Perretta, Marco Nezzo, Federico Romeo Fraioli, Beatrice Carreri, Paola Elda Gigliotti, Andrea Micillo, Andrea Malizia, Daniele Di Giovanni, Colleen Patricia Ryan, Francesco Giuseppe Garaci

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: mpMRI; prostate cancer; TPLA; FLA; focal laser ablation; transperineal laser ablation

Online: 28 February 2024 (04:48:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.0418.v1

LCK Function and Modulation: Immune Cytotoxic Response and Tumor Treatment. More than a Simple Event.

Juan Bautista De Sanctis, Jenny Valentina GARMENDIA, Hana Duchová, Viktor Valentini, Alex Puskasu, Agata Kubíčková, Marián Hajdúch

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Src kinases, Lck, hematologic tumors, solid tumors, T-cell cytotoxicity, NK cytotoxicity, CAR-T cell, cell proliferation, cell adhesion.

Online: 4 July 2024 (13:31:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0822.v1

3D Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment

Syarifah Tiara Noorintan, Chelsie Angelius, Fuad Gandhi Torizal

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: 3D organoid models; Cancer immunotherapy; Personalized treatment; Bioengineering; Culture methods

Online: 12 August 2024 (12:49:00 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202406.2022.v1

Extremely Rare Case of Successful Treatment of Foot Ulcer Associated with Evans’ Syndrome and Buerger's Disease

Ha Jong Nam, Se Young Kim, Je Yeon Byeon, and Hwan Jun Choi

Subject: Medicine And Pharmacology, Surgery Keywords: Evans' syndrome; Thromboangiitis Obliterans; Thrombosis; Autoimmune Disease; Case Reports

Online: 28 June 2024 (07:03:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1173.v1

Risk of Hepatitis B Virus Reactivation in COVID-19 Patients Receiving Immunosuppressive Treatment – Prospective Study

Nicoleta Mihai, Mihaela Cristina Olariu, Oana-Alexandra Ganea, Aida-Isabela Adamescu, Violeta Molagic, Ștefan Sorin Aramă, Cătălin Tilișcan, Victoria Aramă

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS-CoV-2; COVID-19; immunosuppressive agents; hepatitis B virus; reactivation

Online: 17 September 2024 (05:09:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1432.v1

Epirubicin and Non-Muscle Invasive Bladder Cancer Treatment: A Systematic Review

Sever Chiujdea, Matteo Ferro, Mihai Dorin Vartolomei, Giuseppe Lucarelli, ,Kensuke Bekku, Akihiro Matsukawa, Mehdi Kardoust Parizi, Jakob Klemm, Ichiro Tsuboi, Tamas Fazekas, Stefano Mancon, Shahrokh F. Shariat

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Epirubicin; intravesical instillations; bladder cancer; chemotherapy; adjuvant treatment

Online: 22 May 2024 (10:27:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0285.v1

Increased Oxidative Stress Toxicity and Lowered Antioxidant Defenses in Temporal Lobe Epilepsy and Mesial Temporal Sclerosis: Associations with Psychiatric Comorbidities

Michael Maes, Thitiporn Supasitthumrong, Chusak Limotai, Ana Paula Michelin, Andressa Keiko Matsumoto, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania G. Moreira, Andre Carvalho, Sunee Sirivichayakul, Decio Barbosa, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: oxidative stress; neuroimmunomodulation; major depression; inflammation; neurotoxicity; schizophrenia

Online: 24 January 2020 (14:46:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1747.v1

Predicting Treatment Outcomes in Patients with Drug-resistant Tuberculosis and HIV Co-infection Using a Supervised Machine Learning Algorithm

Mojisola Clara Hosu, Lindiwe Modest Faye, and Teke Apalata

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: DR-TB; DR-TB/HIV coinfection; treatment outcomes; machine learning; supervised learning algorithm

Online: 23 September 2024 (13:13:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1695.v1

Optimizing Recurrence Reduction in Central Giant Cell Granuloma: A Comparative Analysis of Treatment Modalities

Flamur Aliu, Donika Bajrami Shabani, Iliriana Aliu, Etleva Droboniku, Gerta Kaçani, Luca Fiorillo, Aida Meto

Subject: Public Health And Healthcare, Other Keywords: ; central giant cell granuloma; recurrence; treatment modalities; surgical excision; curettage; corticosteroid injection ;

Online: 22 July 2024 (09:30:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.2173.v1

Circulating Extracellular Mitochondria in Cardiometabolic Disease: Harnessing the Potential for Diagnosis, Prognosis, and Treatment

Michail Spanos, Priyanka Gokulnath, Olivia Rosina Whittaker, Christopher Azzam, Emeli Chatterjee, Aarush Singh, Dimitrios Varrias, Michail Kladas, Guoping Li, Gururaja Vulugundam, Saumya Das

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Circulating Extracellular Mitochondria; Cardiometabolic Disease; Diabetes; Obesity

Online: 3 June 2024 (08:10:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0297.v1

The Impact of Foehn Wind on Mental Distress among Patients in a Swiss Psychiatric Hospital

Christian A. Mikutta, Charlotte Pervilhac, Hansjörg Znoj, Andrea Federspiel, Thomas J Müller

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: foehn wind; psychopathology; BSCL; mental health; weather; meteorological factors; climate change

Online: 17 August 2022 (04:04:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0682.v1

Psilocybin for Treating Psychiatric Disorders: Is it a Psychonaut Legend or a Promising Therapeutic Perspective?

Maurizio Coppola, Francesco Bevione, Raffaella Mondola

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: psilocybin; psilocin; psychedelics; magic mushrooms

Online: 28 June 2021 (16:00:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1527.v1

Daily and Weekly “High Doses” of Cholecalciferol for the Prevention and Treatment of Vitamin D Deficiency for Obese or Multi-morbidity and Multi-treatment Patients Requiring Multi-drugs – A Narrative Review

Pawel Pludowski, Ewa Marcinowska-Suchowierska, Galym Togizbayev, Zhanna Belaya, William B. Grant, Stefan Pilz, Michael F. Holick

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: vitamin D in high dose; 7,000 IU per day; 30,000 IU per week; 50,000 IU per week; effectiveness; safety; intermittent doses

Online: 19 July 2024 (02:51:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints201703.0052.v1

Oral Mucositis: Melatonin Gel an Effective New Treatment

Ahmed E Abdel-Moneim, Ana Guerra-Librero, Javier Florido, Ying-Qiang Shen, Beatriz Fernández-Gil, Darío Acuña-Castroviejo, Germaine Escames

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mucositis; radiotherapy; chemotherapy; pathophysiology; management; melatonin

Online: 9 March 2017 (04:46:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1584.v1

Panmacular Micropulse Laser Treatment of Central Serous Chorioretinopathy: Two-Year Follow-Up of Morphological and Functional Parameters

Małgorzata Latalska, Sławomir Dresler, Robert Rejdak

Subject: Medicine And Pharmacology, Ophthalmology Keywords: panmacular micropulse laser treatment; central serous chorioretinopathy; choroidal thickness; pachyvessel; microperimetry; vessel density

Online: 26 March 2024 (14:17:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.1711.v1

Dermatological Neoplastic Diseases Complicating Treatment with Monoclonal Antibody for Multiple Sclerosis

Floriana Bile, Maddalena Sparaco, Eleonora Ruocco, Giuseppina Miele, Elisabetta Maida, Renato Vele, Davide Mele, Simona Bonavita, Luigi Lavorgna

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Multiple Sclerosis; Skin cancer; Monoclonal antibodies.

Online: 22 July 2024 (11:47:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0561.v1

Treatment with Ascorbyl Glucoside Arginine Complex Ameliorates Solar Lentigos

Mariko Takada, Kayoko Numano, Masahiko Nakano, Akio Yamamoto, Genji Imokawa

Subject: Medicine And Pharmacology, Dermatology Keywords: Ascorbyl Glucoside Arginine Complex; solar lentigo; double‐blind half‐face study; pigmentation; L value; melanin index

Online: 8 August 2024 (12:28:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2165.v1

In vitro Photodynamic Therapy in the Treatment of Endometrial Cancer

Aleksandra Żołyniak-Brzuchacz1, Edyta Barnaś, David Aebisher, Magdalena Szpunar, Klaudia Dynarowicz, Elżbieta Ostańska, Joanna Skręt-Magierło, Tomasz Kluz, Dorota Bartusik-Aebisher

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Keywords endometrial cancer; photodynamic therapy; in vitro; treatment; rose bengal

Online: 31 May 2024 (15:11:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0142.v1

Non-Union Treatment in the Foot, Ankle, and Lower Leg: A Multicenter Retrospective Study Comparing Conventional Treatment with the Human Allogeneic Cortical Bone Screw (Shark Screw®)

Viktor Labmayr, Elisabeth Huber, Florian Wenzel-Schwarz, Patrick Holweg, Martin Ornig, Gerd Jakob, Wolfgang Palle, Gudrun H. Borchert, Klaus Pastl

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: bone healing; non-union; human allogeneic cortical bone screw; Shark Screw®; ; allograft; pseudarthrosis; foot and ankle; time to union; delayed union; return to work; hardware removal; health care costs

Online: 4 March 2024 (14:04:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0608.v1

Performance of a Solar Driven Photocatalytic Membrane Reactor for Municipal Wastewater Treatment

Mirela Alina Constantin, Lucian Alexandru Constantin, Ioana Alexandra Ionescu, Cristina Mihaela Nicolescu, Marius Bumbac, Olga Tiron

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: PMR; solar light; wastewater; advanced treatment; photo catalysis; membrane processes

Online: 12 February 2024 (09:45:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0195.v1

Testing the Reliability and Construct Validity of Short-Term Assessment of Risk and Treatability (START) in Non-Western Forensic Psychiatric Inpatients

Weeerapong Sanmontree, Peera Wongupparaj

Subject: Social Sciences, Psychology Keywords: Thai START; Forensic psychiatric inpatients; Confirmatory factor analysis with ordinal data; Violence risk assessment; forensic psychology; Psychometrics

Online: 13 January 2022 (15:57:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.0980.v1

A Benefaction of Flavonoids as Epigenetic Modulators for Effective Cancer Treatment

Amol D. Gholap, Vivek P Chavda, Dixa A. Vaghela, Sampada D. Sawant, Navnath T Hatvate, Lalitkumar K. Vora, Deblina Bhowmik, Bairong Shen, Pankti C. Balar, Rajeev K. Singla

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: cancer; Chemotherapy; DNA methylation; Epigenetic; Flavonoids

Online: 11 July 2024 (12:38:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0704.v1

TREE: Reducing the Use of REstrictive Practices on Psychiatric Wards through Virtual REality Immersive Technology Training

Peter Phiri, Laura Pemberton, Yang Li, Xiaojie Yang, Joe Salmon, Isabel Boulter, Sana Sajid, Jackie Clark, Andy McMillan, Jian Shi, Gayathri Delanerolle

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Virtual Reality; restrictive practices; inpatient wards; restraint; isolation; rapid tranquilisation; covert medication; procedural restrictions; health professions training

Online: 10 November 2023 (11:11:28 CET)

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BACKGROUNDRestrictive practices are defined by measures linked to physical and chemical restraints to reduce the movement or control behaviours during any emergency. Seclusion is an equal part of restrictive practices intended to isolate and reduce the sensory stimulation to safeguard the patient and those within the vicinity. Using interventions by way of virtual reality (VR) could assist with reducing the need for restrictive practices as it could help reduce anxiety or agitation by way of placing users into realistic and immersive environments. This could also aid staff to and change current restrictive practices.AIMTo assess the feasibility and effectiveness of using a VR platform to provide reduction in restrictive practice (RRP) training. METHODSThe study received ethics approval was obtained prior to starting the study from the Health Research Authority in United Kingdom (22/HRA/3030 REFERENCE). A randomised controlled feasibility study was conducted alongside of an evaluation at at 1 month and 6 within inpatient psychiatric wards at Southern Health NHS Foundation Trust, UK. Virti Virtual Reality scenarios will be used on VR headsets to provide training on reducing restrictive practices in 3 inpatient psychiatric wards. Outcome measures included General Self-Efficacy (GSE) scale, Generalised Anxiety Disorder Assessment 7 (GAD-7), Burnout Assessment Tool (BAT-12), The Everyday Discrimination (EDS) Scale, and the Compassionate Engagement and Action (CEA) Scale. RESULTSThe statistical significance of most variables is high, with the exception of the BAT12 score, compassionate engagement to others score, compassionate to others total score, compassionate engagement from others score, and compassionate from others total score, which exhibit lower statistical power in two-sample t-tests. To assess the acceptability, preference, and adherence of users to the Virti VR technology for RRP training, we calculated the System Usability Scale (SUS) scores and visualized the program's completion using pie charts. The majority of respondents reported SUS scores exceeding 70, with a mean SUS score of 71.79. In accordance with the insights provided by Bangor et al. (38), the VR platform demonstrated superior usability compared to approximately 62% of other products. we utilized the GAD7 score to assess the confidence levels within the two groups. We compared the data for the VR group and the control group after one month, as well as the baseline and one-month data for both the VR group and the control group. Given that the p-values are below 0.05 and the statistical power is high, it can be concluded that there are no statistically significant differences in confidence levels between the VR and control groups at baseline and day-30. CONCLUSIONSOur study has revealed the challenges associated with implementing such a program, even though the staff has given it high usability ratings. With the ongoing advancement of VR technology, we have the capability to create scenarios and simulations tailored to various healthcare environments. This empowers staff to receive more comprehensive and effective training for handling a wide range of situations.

Preprint REVIEW | doi:10.20944/preprints202407.0913.v1

Understanding the Impact of Oxidative Stress on Ovarian Cancer: Advances in Diagnosis and Treatment

Yeva Meshkovska, Artem Abramov, Shaheen Mahira, Sowjanya Thatikonda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Reactive Oxygen Species, Ovarian Cancer, Oxidative Stress, Ovarian Cancer Treatment.

Online: 11 July 2024 (12:44:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0091.v1

A Novel Methods for Fracture Toughness Evaluation of Tool Steels with Post-Tempering Cryogenic Treatment

Ramona Sola, Roberto Giovanardi, Paolo Veronesi, Giovanni Parigi

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: fracture toughness, scratch test, residual stress, tool steel, cryogenic treatment

Online: 24 February 2017 (14:46:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1319.v1

Mental Health Attitudes and Perspectives of an Arab American Community: Beliefs Associated with Stigma, Treatment, and the Origins of Pathology

Liam Browning, Nicole Oska, George Kidess, Liza Hinchey, Arwa Saleem, Sadie Knill, Malaak Elhage, Arash Javanbakht

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Arab American; mental health; stigma; attitudes

Online: 17 September 2024 (12:14:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0123.v1

Using Radiofrequency Identification Automated Technologies for Predictive Analytics of Signaling Factors to Determining In-Patient Post Treatment Sleep Quality

Haley Hudson, Erick Jones, Dawit Aberra, Shalini Gupta, Felicia Jefferson

Subject: Public Health And Healthcare, Other Keywords: EMG; EEG; ECG; EOG; polysomnography

Online: 25 December 2016 (08:34:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0458.v1

Beyond the Penrose Hypothesis: Examining the Association between the Availability of Psychiatric Care and National Homicide Rates in 166 Countries

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental illness; homicide; violence; psychiatry; Penrose hypothesis; deinstitutionalization

Online: 26 August 2022 (10:00:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0402.v1

Effects of Heat Treatment on the Microstructure and Mechanical Properties of a Dual-Phase High-Entropy Alloy Fabricated via Selective Laser Melting

Xiaojun Tan, Zihong Wang, Haitao Chen, Xuyun Peng, Wei Zhang, Haibing Xiao, Zhongmin Liu, Yu Hu, Liang Guo, Qingmao Zhang

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: high-entropy alloy; selective laser melting; heat treatment; dual-phase; tailorable microstructure; mechanical property

Online: 7 February 2024 (08:08:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.1311.v1

Exosome-Like Systems: From Therapies to Vaccination for Cancer Treatment and Prevention—Exploring the State of the Art

Hamid Heydari Sheikhhossein, Francesca Iommelli, Natalia Di Pietro, Maria Cristina Curia, Adriano Piattelli, Rosanna Palumbo, Giovanni N Roviello, Viviana De Rosa

Subject: Biology And Life Sciences, Life Sciences Keywords: exosomes; cancer vaccines: immune system

Online: 19 April 2024 (08:09:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0178.v1

A Meta-Analytical Way of Systematizing the Use of Hyaluronan Gels for the Relief of Osteoarthritis, Compared with New Treatment Alternatives

Tudor Pinteala, Stelian Sergiu Maier, Norin Forna, Liliana Savin, Mihnea Theodor Sirbu, Dragos Cristian Popescu, Viorel Dan Cionca, Dan Constantin Putineanu, Paul Dan Sirbu

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: hyaluronic acid; viscosupplementation; platelet-rich plasma; osteoarthritis; meta-analysis; meta-regression; reproducible research

Online: 2 July 2024 (14:48:57 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.0594.v1

From CBT to Complex Therapy: A Novel Approach to the Treatment of Mental Disorders

Tullio Scrimali

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Complex Therapy; Psychiatry; Psychotehrapy; CBT; MindLAB Set; NegEnt

Online: 11 March 2024 (10:29:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1896.v2

Relationship of Maternal Age and Adverse Childhood Experiences (ACEs) with Traumatic Sequelae in Commercially Sexually Exploited Youth

Kirsten Byrnes, HaeSung Han, Kie Fujii

Subject: Social Sciences, Psychiatry And Mental Health Keywords: trafficked youth and trauma; ACEs; early maternal age; teen pregnancy; exploitation and trauma; self-harm; psychological trauma

Online: 18 August 2023 (07:25:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0087.v1

Current Treatment Approaches to Eliminate Borrelia burgdorferi and Potential Strategies to Alleviate Persistent Lyme Disease Symptoms

Kashaf Zafar, Onyedikachi Azuama, Nikhat Parveen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Lyme disease; Borrelia burgdorferi; Treatment; antimicrobials; Post-treatment Lyme disease syndrome; PTLDS

Online: 2 May 2024 (12:03:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1313.v1

The Current State of Digital Technologies for the Treatment and Management of PTSD- A Look into the Future of Psychiatry

Liam Browning, Imran Rashid, Arash Javanbakht

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: digital health; mental health; PTSD; virtual reality; digital phenotyping

Online: 17 September 2024 (11:55:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1958.v1

Caveolae with GLP-1 and NMDA Receptors as Crossfire Points for the Innovative Treatment of Cognitive Dysfunction with Neurodegenerative Diseases

Moeka Nakashima, Naoko Suga, Sayuri Yoshikawa, Satoru Matsuda

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: caveolae; caveolin; glucagon-like peptide-1; NMDA; autophagy; mitophagy; cognitive dysfunction; Alzheimer's disease

Online: 24 July 2024 (11:52:56 CEST)

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