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Preprint ARTICLE | doi:10.20944/preprints202309.0003.v1

Human Milk Redox Homeostasis: The Gestational Pathologies Effect

Chiara Peila, Lorenzo Riboldi, Elena Spada, Alessandra Coscia, Ignazio Barbagallo, Giovanni Livolti, Fabio Galvano, Diego Gazzolo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Human milk; breastfeeding; GSH; LOOHs; preeclampsia; gestational diabetes mellitus; newborn nutrition

Online: 1 September 2023 (13:45:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0180.v2

Redox Homeostasis and Nitro-Oxidative Stress in Obesity-Linked Inflammation

Guillaume Treiber, Hanen Samouda, Estelle Nobécourt, Serge P. Bottari

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: oxidative stress; nitrative stress; reactive oxygen species; reactive nitrogen species; nitric oxide inflammation; obesity; peroxynitrite; adipose tissue

Online: 30 September 2022 (11:10:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0525.v2

4-Hydroxynonenal in Redox Homeostasis of Gastrointestinal Mucosa: implications for Stomach in Health and Diseases

Andriy Cherkas, Neven Zarkovic

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: 4-Hydroxynonenal; lipid peroxidation; redox balance; oxidative stress; stomach; peptic ulcer; gastritis; Helicobacter pylori; gastric cancer; non-steroid anti-inflammatory drugs-induced gastropathy

Online: 23 August 2018 (04:24:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.2069.v1

The Redox Homeostasis Alteration Is Restored by Melatonin Treatment in COVID-19 Patients

María Elena Soto, Israel Pérez-Torres, Linaloe Manzano-Pech, Adrían Palaciós-Chavarría, Rafael Ricardo Valdez-Vázquez, Verónica Guarner-Lans, Elizabeth Soria-Castro, Eulises Díaz-Díaz, Vicente Castrejón-Tellez

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Melatonin; SARS-CoV-2; oxidative stress; COVID-19; redox homeostasis; antioxidant enzymes

Online: 31 January 2024 (01:47:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0152.v1

Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Alzheimer’s disease; oxidative stress; presenilin; mitochondria; calcium; neuronal dysfunction; Nrf2

Online: 11 July 2022 (08:03:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0351.v1

Redox Homeostasis Disclosed in the Saltmarsh Plant Halimione portulacoides Upon a Short Waterborne Exposure to Inorganic Mercury

Patrícia Pereira, Joana Luísa Pereira, Ana Marques, Carlos Marques, Fátima Brandão, Rute Cesário, Silja Frankenbach, João Serôdio, Fernando J. M. Gonçalves, João Canário, Mário Pacheco

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Halimione portulacoides; inorganic mercury; bioaccumulation; antioxidant defenses; oxidative damage; photosynthetic activity

Online: 4 January 2024 (05:59:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202008.0094.v1

Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection

Chung-Yang Yeh, Anthony Schulien, Bradley Molyneaux, Elias Aizenman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Ischemic Stroke; Reperfusion; Neuroprotection; Nerinetide; Kv2.1

Online: 4 August 2020 (11:28:48 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.2094.v1

Detection of Mesothelial-to-Mesenchymal Transition-Derived Carcinoma-Associated Fibroblasts in Primary Ovarian Carcinomas

Henar Tomero-Sanz, José Antonio Jiménez-Heffernan, María Concepción Fernández-Chacón, Ignacio Cristóbal-García, Ricardo Sainz de la Cuesta, Lucía González-Cortijo, Manuel López-Cabrera, Pilar Sandoval

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Ovarian cancer; primary tumor; mesothelial cells; carcinoma-associated fibroblasts; mesothelial-to-mesenchymal transition

Online: 31 May 2024 (08:10:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1751.v1

Antioxidant Activity of Planar Catechin Conjugated with Trolox

Wakana Shimizu, Yoshimi Shoji, Kei Ohkubo, Hiromu Ito, Ikuo Nakanishi, Kiyoshi Fukuhara

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: catechin; trolox; tocopherol; antioxidant activity

Online: 23 August 2024 (17:13:26 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202406.1617.v1

Recombinant C-terminal Catalytic Domain of Rat L-gulono Lactone Oxidase Produced in Bacterial Cells Is Enzymatically Active

Abdul Aziz Mohamed Gad, Anna Gora-Sochacka, Agnieszka Sirko

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gulonolactone oxidase; recombinant protein; GULO activity; His-tag

Online: 24 June 2024 (08:44:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0079.v1

NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity

Sanaz Dastghaib, Seyed Mohammad Shafiee, Fatemeh Ramezani, Niloufar Ashtari, Farhad Tabasi, Javad Saffari-Chaleshtori, Omid Vakili, Morvarid Siri, Somayeh Igder, Mojdeh Zamani, Mahshid Moballegh Nasery, Fariba Kokabi, Emilia Wiechec, Zohreh Mostafavi-Pour, Pooneh Mokarram, Saeid Ghavami

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: NF-E2-related factor 2; Drug resistance; Reactive oxygen species; Autophagy; Unfolded protein response

Online: 3 January 2024 (02:26:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2146.v2

Bottlenecks in the Investigation of Retinal Sterol Homeostasis

Sriganesh Ramachandra Rao, Steven J. Fliesler

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cholesterol; homeostasis; lipid; lipoprotein; retina; retinal degeneration; sterol

Online: 14 February 2024 (09:57:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0506.v1

Redox Regulation of LAT Enhances T Cell-Mediated Inflammation

Jaime James, Ana Coelho, Gonzalo Fernandez Lahore, Clara Marquina Hernandez, Florian Forster, Bernard Malissen, Rikard Holmdahl

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: NCF1; Reactive Oxygen Species; Linker for Activation of T cells; T cell receptor signaling; Rheumatoid Arthritis

Online: 8 March 2024 (11:03:29 CET)

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Preprint ESSAY | doi:10.20944/preprints202408.1624.v2

Homeostasis - Resiliance and Susceptibility

Steven Olsen

Subject: Public Health And Healthcare, Primary Health Care Keywords: Disease causation; Homeostasis profile; Set point reference images; Resilience; Susceptibility; Stress/Reaction Dynamics; Epigenetics

Online: 22 September 2024 (06:40:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0043.v1

The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction

Hilary Y. Liu, Jenna R. Gale, Ian J. Reynolds, John H. Weiss, Elias Aizenman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: zinc, mitochondria, neurodegeneration, calcium, energy metabolism, mitochondrial dynamics

Online: 2 March 2021 (09:03:05 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202407.1192.v2

Rebuilding Quantum Homeostasis

Steven Olsen

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Homeostasis; Epigenetics; Epimutations; ; Hormesis; Toxicogenomics; Quantum biology; Superposition reference image; Ultra high dilutions; Quantum drug action

Online: 16 September 2024 (10:16:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1724.v1

Mitigative Effect of Graphene Oxide Nanoparticle in Maintaining Gut-Liver Homeostasis against Alcohol Injury

Hiral Aghara, Prashsti Chadha, Palash Mandal

Subject: Biology And Life Sciences, Life Sciences Keywords: Graphene oxide nanoparticles; Gut - liver axis; Alcoholic liver disease; Inflammation; Lipolysis

Online: 26 April 2024 (11:40:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0536.v1

Biological Interaction and Homeostasis in Evolution

Dozie Iwuh

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: biological interaction; homeostasis; evolution; A. Damasio

Online: 28 December 2022 (09:34:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1876.v1

Regulation of cysteine homeostasis and its effect on Escherichia coli sensitivity to ciprofloxacin in LB medium

Galina Smirnova, Aleksey Tyulenev, Lyubov Sutormina, Tatyana Kalashnikova, Nadezda Muzyka, Vadim Ushakov, Zoya Samoilova, Oleg Oktyabrsky

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: cysteine homeostasis; glutathione; H2S; Fur and SOS regulons; growth; respiration; antibiotics; bacterial survival

Online: 1 April 2024 (10:18:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0122.v2

Novel NH4V4O10-Reduced Graphene Oxide Cathodes for Zinc-Ion Batteries: Theoretical Predictions and Experimental Validation

He Lin, Chenfan Liu, Yu Zhang

Subject: Chemistry And Materials Science, Electrochemistry Keywords: zinc-ion batteries; cathode materials; NH4V4O10; reduced graphene oxide

Online: 24 June 2024 (13:52:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0436.v1

SUMOylation in Skeletal Development, Homeostasis, and Disease

Tao Yang, Huadie Liu, Sonya E. L. Craig, Vladimir Molchanov, Joe Floramo, Yaguang Zhao

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: SUMO; MSC; osteoblast; chondrocyte; osteoclast; signaling pathway; arthritis; osteosarcoma; developmental disorders

Online: 28 July 2022 (09:04:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0392.v1

Hydrogen Peroxide and Redox Regulation of Development

Christine Rampon, Michel Volovitch, Alain Joliot, Sophie Vriz

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: H2O2, redox signalling, development, regeneration, adult stem cells, metazoan

Online: 19 September 2018 (21:42:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0029.v1

Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review.

Renate Viebahn-Haensler, Olga León Fernández

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: redox bioregulation; mitochondriopathies; low-dose ozone concept; ozone therapy; oxidative stress; antioxidant capacity

Online: 1 May 2024 (07:29:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0824.v1

Building Up a Human Ovarian Antioxidant ceRNA Network, OvAnOx: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and Dysfunctions

Carla Tatone, Giovanna Di Emidio, Rosalia Battaglia, Cinzia Di Pietro

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: ceRNA network; oxidative stress; female fertility; antioxidant cell defence; non-coding RNAs

Online: 12 August 2024 (14:02:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0241.v1

Sorting Nexins in Protein Homeostasis

Sarah E Hanley, Katrina F Cooper

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Sorting nexins; UPS; autophagy

Online: 6 November 2020 (10:41:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2132.v1

Emerging Role of GCN1 in Disease and Homeostasis

Yota Tatara, Shuya Kasai, Daichi Kokubu, Tadayuki Tsujita, Junsei Mimura, Ken Itoh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: GCN1; amino acid starvation; ribosome; disome; GCN2; RWD domain; ribosomal stress surveillance

Online: 31 January 2024 (03:01:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0158.v1

Homeostasis Model Assessment for Insulin Resistance Mediates the Positive Association of Triglycerides with Diabetes

Yutang Wang, Yan Fang, MICHAL VRABLIK

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: insulin resistance; lipoprotein; diabetes; mediation analysis

Online: 5 March 2024 (05:54:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0648.v1

Enhancing Polysulfide Redox Kinetics Through Synergistic Polarization of Ferroelectric (Ba0.9Sr0.1TiO3) Nanoparticles for High-Capacity Li-S Batteries.

Ivan Castillo, Balram Tripathi, Danilo Barrionuevo, Karuna K. Mishra, Gerardo Morell, Ram S. Katiyar

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: Li-S battery; C/S composite; BST coupling; polysulfide trapping; ferroelectric material

Online: 9 August 2024 (12:09:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1837.v1

Disturbances in the Skin Homeostasis: The Wound Healing, a Process Yet to Be Defined

Montserrat Fernández-Guarino, Jorge Naharro-Rodriguez, Stefano Bacci

Subject: Biology And Life Sciences, Life Sciences Keywords: acute wounds; chronic wounds; hypertrophic scars; keloids; skin; wound healing

Online: 28 April 2024 (08:29:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1649.v2

Phylogenetic Analysis of Pyruvate-Ferredoxin Oxidoreductase, a Redox Enzyme Involved in the Activation of Nitro-Based Prodrugs in Bacteria and Protozoa

Seth Duwor, Daniela Brites, Pascal Mäser

Subject: Biology And Life Sciences, Life Sciences Keywords: Pyruvate-ferredoxin oxidoreductase; metronidazole; reductive bioactivation; antimicrobial spectrum; comparative genomics; horizontal gene transfer ;

Online: 1 March 2024 (07:57:55 CET)

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Simple Summary: The distribution of typical bacterial redox enzymes such as pyruvate-ferredoxin oxidoreductase (PFOR) in protozoa remains interestingly puzzling. Previous studies have demonstrated diverse cellular localizations of PFOR in some amitochondriate anaerobic protozoa. PFOR is of particular pharmacological importance because it catalyzes the reductive bio-activation of nitro-based prodrugs to cytotoxic radical metabolites. Metronidazole was developed primarily as an antiprotozoal agent against infections caused by Trichomonas vaginalis. However, its antimicrobial spectrum was subsequently expanded to cover anaerobic bacterial infections. It has been shown that mutations in the genes encoding PFOR result in inherent resistance of PFOR-possessing anaerobic protozoa and bacteria to nitro-based prodrugs. Deciphering the evolutionary history of PFOR is crucial in deepening our understanding of the evolution of anaerobic pathogens and unfold new approaches for drug discovery and targeting in pathogen chemotherapy. Abstract: The present frontrunners in the chemotherapy of infections caused by protozoa are nitro-based prodrugs that are selectively activated by PFOR-mediated redox reactions. This study seeks to analyze the distribution of PFOR in selected protozoa and bacteria by applying comparative bioinformatics approaches to test the hypothesis that PFOR was most likely acquired through horizontal gene transfer (HGT) from bacteria. Furthermore, to identify other genes that were putatively acquired using proteome-wide and gene expression analyses. A plausible explanation for the patchy occurrence of PFOR in protozoa is based on the hypothesis that bacteria are potential sources of genes that enhance optimal adaptation of protozoa in hostile environments. The exclusively expressed proteins obtained from Entamoeba histolytica and the putative gene donor, Desulfovibrio vulgaris, showed an over-expression of eleven genes involved in intermediary metabolism. If these results can be reproduced in other PFOR-possessing protozoa, it would provide a more validated evidence to support the horizontal transfer of pfor from bacteria.

Preprint ARTICLE | doi:10.20944/preprints201811.0422.v1

Polyamine Homeostasis in Snyder-Robinson Syndrome

Tracy Murray Stewart, Matthew Dunworth, Jackson R. Foley, Charles E. Schwartz, Robert A. Casero, Jr.

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: snyder-robinson syndrome; spermine synthase; X-linked intellectual disability; polyamine transport; spermidine; spermine; transglutaminase

Online: 19 November 2018 (06:49:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.1643.v1

Microbiome—Stealth Regulator of Breast Homeostasis and Cancer Metastasis

Saori Furuta

Subject: Biology And Life Sciences, Life Sciences Keywords: breast cancer; cancer metastasis; tumor-resident bacteria; microbiome; metabolites

Online: 22 August 2024 (11:36:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1889.v1

Cholesterol Homeostasis, Mechanisms of Molecular Pathways, and Cardiac Health

Rajiv Kumar

Subject: Biology And Life Sciences, Biophysics Keywords: cholesterol homeostasis; cardiac remodeling; inflammation; atherosclerotic; cardiomyocytes; atherosclerosis; catabolic and anabolic pathways

Online: 29 August 2023 (03:39:04 CEST)

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The metabolism of lipoproteins, which regulates the transit of the lipid to and from tissues, is crucial to maintaining cholesterol homeostasis. Cardiac remodeling is referred to as a set of molecular, cellular, and interstitial changes that, following injury, affect the size, shape, function, mass, and geometry of the heart. Acetyl coenzyme A (acetyl CoA), which can be made from glucose, amino acids, or fatty acids, is the precursor for the synthesis of cholesterol. In this article, authors explain concepts behind cardiac remodeling, its clinical ramifications, and the pathophysiological roles played by numerous various components, such as cell death, neurohormonal activation, oxidative stress, contractile proteins, energy metabolism, collagen, calcium transport, inflammation, and geometry. The levels of cholesterol are traditionally regulated by two biological mechanisms at the transcriptional stage. First, the SREBP transcription factor family regulates the transcription of crucial rate-limiting cholesterogenic and lipogenic proteins, which in turn limits cholesterol production. Immune cells become activated, differentiated, and divided, during an immune response with the objective of eradicating the danger signal. In addition to creating ATP, which is used as energy, this process relies on metabolic reprogramming of both catabolic and anabolic pathways to create metabolites that play a crucial role in regulating the response. Because of changes in signal transduction, malfunction of the sarcoplasmic reticulum and sarcolemma, impairment of calcium handling, increases in cardiac fibrosis, and progressive loss of cardiomyocytes, oxidative stress appears to be the primary mechanism that causes the transition from cardiac hypertrophy to heart failure. De novo cholesterol production, intestinal cholesterol absorption, and biliary cholesterol output are consequently crucial processes in cholesterol homeostasis. In the article's final section, the pharmacological management of cardiac remodeling is explored. The route of treatment is explained into different steps: including, promising, and potential strategies. This chapter offers a brief overview of the history of the study of cholesterol absorption as well as the different potential therapeutic targets.

Preprint ARTICLE | doi:10.20944/preprints202307.1684.v1

Redox Metabolism and Vascular Calcification in Chronic-Kidney Disease

Cristina Alonso-Montes, Natalia Carrillo-López, Sara Panizo, Beatriz Martín-Carro, Juan Carlos Mayo Barrallo, Pablo Román-García, Raúl García-Castro, Jesús M. Fernández-Gómez, Miguel A. Hevia-Suárez, Julia Martín-Vírgala, Sara Fernández-Villabrille, Laura Martínez-Arias, Sara Barrio Vázquez, Laura Calleros Basilio, Jorge Benito Cannata-Andía, Manuel Naves-Díaz, José Luis Fernández-Martín, Isabel Quirós-González

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Vascular calcification; Catalase; CKD; RUNX2; Epigastric arteries; DIGE

Online: 26 July 2023 (02:38:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0130.v1

Neurochemical Basis of Energy Homeostasis in Health and Obesity

Dhanush Haspula, Zhenzhong Cui

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Obesity; hypothalamus; appetite; glucose homeostasis; weight-loss drugs; AGRP; POMC; NTS; incretins

Online: 3 May 2023 (10:22:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0293.v1

Microgravity, Bone Homeostasis, and Insulin-like Growth Factor-1

John Kelly Smith

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Insulin-like growth factor-1; Insulin-like growth factor-1 receptor; microgravity; osteoblasts; osteocytes; osteoclasts; IGF-1; IGF1R; rIGF-1

Online: 18 May 2020 (03:31:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0107.v1

Thioredoxins o1 and h2 Show Different Subcellular Localizations and Redox-Active Functions, but Cooperatively Affect NADPH Redox Poise and Photosynthetic Performance in Fluctuating Light

Liang-Yu Hou, Martin Lehmann, Peter Geigenberger

Subject: Biology And Life Sciences, Plant Sciences Keywords: Trx o1; Trx h2; metabolomics; ascorbate; glutathione; NAD(P)(H); photosynthetic performance; fluctuating light; Arabidopsis thaliana

Online: 2 March 2021 (16:19:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0024.v1

The Writers, Readers and Erasers in Redox Regulation of GAPDH

Maria Tossounian, Bruce Zhang, Ivan Gout

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: GAPDH; metabolism; moonlighting protein; redox regulation; oxidative PTMs; S-thiolation

Online: 1 December 2020 (13:14:47 CET)

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Preprint REVIEW | doi:10.20944/preprints201904.0155.v1

Rho GTPases – Emerging Regulators of Glucose Homeostasis and Metabolic Health

Lisbeth L.V. Møller, Amira Klip, Lykke Sylow

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Rho GTPases; metabolism; glucose homeostasis; GLUT4 translocation; skeletal muscle; pancreas; insulin; diabetes; ageing

Online: 13 April 2019 (05:20:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0019.v1

Techno-Economic Modeling and Analysis of Redox Flow Battery Systems

Jens Noack, Lars Wietschel, Nataliya Roznyatovskaya, Karsten Pinkwart, Jens Tübke

Subject: Engineering, Energy And Fuel Technology Keywords: redox flow battery; techno-economic analysis; materials; cost

Online: 2 August 2016 (11:41:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0737.v3

Monitoring the Redox Status in Multiple Sclerosis

Masaru Tanaka, László Vécsei

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: oxidative stress; redox; antioxidant; multiple sclerosis; biomarker; neurodegenerative disease; personalized medicine

Online: 22 September 2020 (08:42:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0284.v1

Cbfβ Is a Novel Modulator Against Osteoarthritis by Maintaining Articular Cartilage Homeostasis Through TGF-Ꞵ Signaling

Xiangguo Che, Xian Jin, Narae Park, Hee-June Kim, Hee-Soo Kyung, Hyun-Ju Kim, Jane B. Lian, Janet L. Stein, And Je-Yong Choi

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: articular cartilage; Runx1/Cbfβ complex; Osteoarthritis; TGF-β signaling; proteasomal degradation

Online: 16 February 2023 (09:40:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1238.v1

Plasma Redox Balance in Advanced Maternal Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

Elena Grossini, Carmen Imma Aquino, Sakthipriyan Venkatesan, Libera Troia, Eleonora Tizzoni, Federica Fumagalli, Daniela Ferrante, Rosanna Vaschetto, Valentino Remorgida, Daniela Surico

Subject: Medicine And Pharmacology, Reproductive Medicine Keywords: aging; antioxidants; lipid peroxidation; nitric oxide; pregnancy

Online: 20 March 2024 (16:56:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0390.v1

Redox Metabolism Measurement in Mammalian Cells and Tissues by LC-MS

Naama Kanarek, Boryana Petrova, Anna Warren, Nuria Yulia Vital, Adam G Maynard, Alan Wong

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: redox metabolites; mass-spectrometry method; HILIC chromatography; NADH; NADPH; Glutathione; redox metabolite detection in mammalian cells

Online: 14 April 2021 (16:09:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0094.v1

An Unexpected Role for GPR143 in Retinal Homeostasis

Dorothy Tung, Nicole R. Congrove, Anna Gabriela Figueroa, Remington M Bliss, Tawanda Zvavamwe, Brian S. McKay

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Retinal pigment epithelium of the eye; RPE; AMD (Age-related Macular Degeneration); GPR143; L-DOPA; Melanin; Ocular albinism; Exosome; Photoreceptor outer segment; Cathepsin D.

Online: 5 January 2023 (02:58:31 CET)

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Age-related macular degeneration is one of the most common causes of blindness, and the incidence exhibits profound racial bias, occurring most frequently in Caucasians. A primary cell type affected in the disease is the retinal pigment epithelium, but the etiology is unclear. The end 10% of the photoreceptor outer segments are shed each day, and the underlying retinal pigment epithelium engulfs, digests, and recycles molecules back to the sensory retina. In previous work, we showed that GPR143 signaling in response to L-DOPA may be effective in the prevention or delay of age-related macular degeneration. In this study, we explore a novel potential effector of GPR143 signaling, that of outer segment uptake and digestion. Using isolated outer segments, labelled with a pH-sensitive marker to fluoresce in lysosomes, we show that GPR143 signaling does not impact outer segment uptake, but does have a significant effect on subsequent degradation. Interestingly, GPR143 signaling did not affect the digestive capacity of the cells, marked by total proteolytic capacity and cathepsin D activity. Rather, our data suggest GPR143 improved endosomal trafficking efficiency of the phagocytosed outer segments to the lysosome. This result is similar to the effect we previously reported for GPR143 on exosome release from the endosomal compartment. Our data illustrate that GPR143 is active in endosomal traffic A single paragraph of about 200 words maximum. For research articles, abstracts should give a pertinent overview of the work. We strongly encourage authors to use the following style of structured abstracts, but without headings: (1) Background: Place the question addressed in a broad context and highlight the purpose of the study; (2) Methods: briefly describe the main methods or treatments applied; (3) Results: summarize the article’s main findings; (4) Conclusions: indicate the main conclusions or interpretations. The abstract should be an objective representation of the article and it must not contain results that are not presented and substantiated in the main text and should not exaggerate the main conclusions.

Preprint ARTICLE | doi:10.20944/preprints202003.0379.v1

Mass Transport Optimization for Redox Flow Battery Design

Nicholas Gurieff, Declan Finn Keogh, Mark Bladry, Victoria Timchenko, Donna Green, Ilpo Koskinen, Chris Menictas

Subject: Engineering, Energy And Fuel Technology Keywords: vanadium redox flow battery; power density; limiting current; cell geometry; mass transfer; electrolyte mixing; static mixer; industrial design; multidisciplinary research; energy transitions

Online: 26 March 2020 (01:51:17 CET)

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Preprint REVIEW | doi:10.20944/preprints201811.0032.v1

A Homeostasis Breakdown Model of Subjective Cognitive Decline

Akiko Mizuno, Maria Ly, Howard J. Aizenstein

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: subjective cognitive decline; preclinical dementia; fMRI; compensation

Online: 2 November 2018 (07:17:11 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0408.v1

Redox Regulation of PTEN by Bicarbonate and Hydrogen Peroxide: Implication of Peroxymonocarbonate

Vu Hoang Trinh, Jin Myung Choi, Thang Nguyen Huu, Dhiraj Kumar Sah, Hyun Joong Yoon, Sang Chul Park, Yu Seok Jung, Youngkeun Ahn, Seung-Rock Lee

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: PTEN; redox regulation; H2O2; bicarbonate; peroxymonocarbonate.; cell signaling

Online: 7 February 2024 (06:02:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0046.v1

Hydroxyhydroquinone and Quassinoids as Promising Compounds with Hypoglycemic Activity through Redox Balance

Paulo Roberto dos Santos, Sidineia Danetti, Joseph Rastegar, Wellington De Souza, Rafaele Frassini, Fernando Joel Scariot, Sidnei Moura, Mariana Roesch-Ely

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: hydroxyhydroquinone; quassinoids; glycemia

Online: 2 August 2023 (05:20:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1615.v1

Restoring Homeostasis as a Promising Therapeutic Strategy for Obesity and Sleep Disorders

Vijay Kumar, Shampa Ghosh, Pradeep Kumar Mishra, Areeba Aziz, Rachna Mehta, Jitendra Kumar Sinha

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Anti-obesity drugs; BMI; Glucose tolerance; Homeostasis; Obesity; Sleep disturbances; Molecular pathology

Online: 23 May 2023 (08:15:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1589.v1

Are Protein Cavities and Pockets Commonly Used by Redox Active Signalling Molecules?

John T. Hancock

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: argon; hydrogen peroxide; hydrogen sulfide; hydroxyl radicals; molecular hydrogen; nitric oxide; peroxynitrite; protein cavities; superoxide; xenon

Online: 23 May 2023 (07:12:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0344.v1

Redox Regulation and Oxidative Stress: The Particular Case of the Stallion Spermatozoa

Fernando Juan Peña Vega, Cristian O'Flaherty, Jose M. Ortiz Rodríguez, Francisco E. Martín Cano, Gemma L. Gaitskell-Phillips, María C. Gil, Cristina Ortega Ferrusola

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: horses; spermatozoa; ROS; oxidative stress; redox regulation; equine

Online: 30 September 2019 (08:06:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints201901.0170.v1

Dysbiosis Promotes Gastric Diseases and Impede Therapies by Hijacking Gut Immune Homeostasis

Devinder Toor, Mishi Wsson, Chavi Goel, Naveen Kumar Kaushik, Prashant Kumar, Singh Sandhya, G. Karthikeyan, Anil Kumar, Hridayesh Prakash

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: gut microbiota; macrophages; TLR mimicry; immunoepigenetics; metabolism; sterile inflammation

Online: 17 January 2019 (03:05:26 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0171.v1

Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity, and Aging

Collin Y. Ewald

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: NOX, sulfenylation, Nrf2, SKN-1, centenarians, extracellular matrix, longevity

Online: 10 September 2018 (12:59:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints201711.0096.v1

Roles of the Hedgehog Signaling Pathway in Skin Development, Homeostasis and Cancer

Yoshinori Abe, Nobuyuki Tanaka

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Hedgehog signaling; skin; epidermis; hair follicle; development; homeostasis; basal cell carcinoma; signaling crosstalk

Online: 15 November 2017 (07:11:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1238.v1

Placental Homeostasis of Oxytocin and Its Ability to Affect the Biological Activity of Retinal Cells

Claudette Adegboro, Wenxiang Luo, Meha Kabra, Ryan M. McAdams, Nathaniel York, R I Wijenayake, Kianna Mary Suchla, De-Ann M Pillers, Bikash Ranjan Pattnaik

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Preterm; retinal vascularization; retinopathy; transcriptomic; connectivity; OXT

Online: 16 September 2024 (14:09:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0103.v1

Machine Learning Prediction of the Redox Activity of Quinones

Ilia Kichev, Lyuben Borislavov, Alia Tadjer, Radostina Stoyanova

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: quinones; machine learning; ridge regression; decision tree; ensemble methods; density functional theory; organic electrode materials

Online: 3 October 2023 (09:14:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.2131.v1

Pathophysiology of Virus Infections: The Protein-Homeostasis-System Hypothesis

Hyun-Mi Kang, Kyung-Yil Lee

Subject: Biology And Life Sciences, Virology Keywords: virus infection; virome; microbiota; pathophysiology; immunology; protein-homeostasis-system hypothesis

Online: 1 August 2023 (02:48:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1259.v1

Chlamydomonas reinhardtii a Reference Microorganism for Eukaryotic Molybdenum Homeostasis

Manuel Tejada-Jimenez, Esperanza Leon-Miranda, Angel Llamas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Chlamydomonas; Microalgae; Molybdenum; Homeostasis; Moco

Online: 18 May 2023 (02:13:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0235.v1

Lipid Dys-Homeostasis Contributes to APOE4 Associated AD Pathology

Adina-Nicoleta Lazar, Linda Hanbouch, Lydie Boussicaut, Baptiste Fourmaux, Patricia Daira, Mark John Millan, Nathalie Bernoud-Hubac, Marie-Claude Potier

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: lipid homeostasis; APOE4; Alzheimer’s Disease; Aβ peptide; tau

Online: 16 September 2022 (02:57:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0511.v1

Looking Back at the Early Times of Redox Biology

Leopold Flohe

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Ferroptosis; glutathione peroxidases; heme peroxidases; hydrogen peroxide; lipid peroxidation; nitrogen monoxide radical; superoxide dismutase; superoxide radical; thioredoxin

Online: 26 October 2020 (10:43:02 CET)

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Working Paper REVIEW

Reactive Oxygen Species (ROS) Homeostasis in Influenza Virus Infection

Ker-Kong Chen, Moeko Minakuchi, Kenly Wuputra, Chia-Chen Ku, Jia-Bin Pan, Kung-Kai Kuo, Ying-Chu Lin, Shigeo Saito, Chang-Shen Lin, kazunari K. Yokoyama

Subject: Biology And Life Sciences, Virology Keywords: antioxidation; aryl hydrocarbon receptor; cellular oxidation; nuclear factor E2-related factor 2; reactive oxygen species

Online: 27 November 2019 (04:20:30 CET)

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Preprint REVIEW | doi:10.20944/preprints201910.0048.v1

Role of miRNAs In Bone Homeostasis - A Short Review

Mahmood Ghafoor, Aleena Sumrin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mirna; osteoblast; osteoclsat

Online: 4 October 2019 (11:38:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0148.v1

The Role of NCOA4-Mediated Ferritinophagy in Iron Homeostasis

Naiara Santana-Codina, Joseph D. Mancias

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: NCOA4, ferritinophagy, iron homeostasis, erythropoiesis, ferroptosis, cancer

Online: 9 September 2018 (16:13:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1263.v1

Metabolic and Functional Interaction of H₂S and Sucrose in Maize Thermotolerance through Redox Homeodynamics

Xiao-Er Li, Hong-Dan Zhou, Zhong-Guang Li

Subject: Biology And Life Sciences, Plant Sciences Keywords: Hydrogen sulfide; maize seedlings; redox homeodynamics; sucrose signaling; thermotoleranceugh MG-scavenging system; Calcium; Maize seedling; Methylglyoxal; Methylglyoxal-scavenging system; Thermotolerance

Online: 20 May 2024 (09:51:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0203.v1

Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer

Adrian I Abdo, Zlatko Kopecki

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cold plasma; plasma-activated water; redox signalling; cancer; wound healing; Nrf2; MAPK; PI3K/Akt; endoplasmic reticulum stress

Online: 2 April 2024 (12:22:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0107.v1

On the Redox-Activity and Health-Effects of Atmospheric Primary and Secondary Aerosol: Phenomenology

Francesca Costabile, Stefano Decesari, Roberta Vecchi, Franco Lucarelli, Gabriele Curci, Dario Massabò, Matteo Rinaldi, Maurizio Gualtieri, Emanuela Corsini, Elena Menegola, Silvia Canepari, Lorenzo Massimi, Stefania Argentini, Maurizio Busetto, Gianluca Di Iulio, Luca Di Liberto, Marco Paglione, Igor Petenko, Mara Russo, Angela Marinoni, Gianpietro Casasanta, Sara Valentini, Vera Bernardoni, Federica Crova, Gianluigi Valli, Alice Corina Forello, Fabio Giardi, Silvia Nava, Giulia Pazzi, Paolo Prati, Virginia Vernocchi, Teresa La Torretta, Ettore Petralia, Milena Stracquadanio, Gabriele Zanini, Gloria Melzi, Emma Nozza, Martina Iulini, Donatella Caruso, Lucia Cioffi, Gabriele Imperato, Flavio Giavarini, Maria Battistoni, Francesca Di Renzo, Maria Agostina Frezzini, Cinzia Perrino, Maria Cristina Facchini

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: atmospheric aerosol; chemical composition; secondary aerosol; source apportionment; ultrafine particles; oxidative potential; exposure; toxicology; forecasting; micrometeorology

Online: 12 April 2022 (09:54:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0070.v1

Recent Advances in “pH and Redox Responsive Polymer-Nano- Composites for Cancer Therapy

Shivalingayya Gaddimath, Shivanand Payamalle, Keshavananda Prabhu CP, Jaehyun Hur

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: cancer; biological thiols; stimuli responsive; cancer therapeutics

Online: 4 December 2023 (02:26:05 CET)

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In recent years, cancer therapy has witnessed significant advancements, with a focus on personalized and targeted treatment strategies. One promising approach involves the use of stimuli-responsive biomaterials for site-specific drug release. Among these biomaterials, pH, and redox-triggered polymer-nano composites have gained immense attention due to their ability to respond to the specific tumor microenvironment, enhancing therapeutic efficacy while reducing off-target effects. Cancer cells often exhibit anomalous biochemical properties, attributed to lower cytosolic pH (acidic) and elevated redox potential through the epitomized upregulation of undesired genes. Such biological process substantially imbalance the level ions (protons) and biological thiols glutathione (GHS) in the cytoplasm as well as in the subcellular organelles. Superfluous accumulation of ions and redox imbalance is associated with proliferation, invasion, and growth of tumor. Because of high surface area, deep tissue penetration capability, higher hydrophilicity, hydrophobic interior for drug/gene efficient loading, biocompatibility and site-specific targeting efficiency, functionalized polymer nanocomposites are superior to conventional small molecular materials. Paradoxically conventional methods of drug delivery aided therapeutics accompanied with inherent drug/genes are encapsulated in biocompatible carrier or suitable transfecting agents generally suffered with low bioavailability, uncontrolled drug release, low cellular penetration, cellular internalization, toxicity, and poor drug loading efficiency. To overcome these issues, recently various multifunctional nanomaterials were developed, based on synergistic stimuli responsive aided drug release in a specified cellular or subcellular system. High therapeutic efficacy, of nanoparticles (NPs) mainly associated with surface functionalization through biocompatible polymeric materials, site-specific targeting units accompanied with stimuli responsive components. Followed by therapeutically important drug or genetic materials were loaded into NPs either in covalent or non-covalent approach. Intriguingly, combined pH and redox dual stimuli based functional materials specially based on polymeric nanocomposites for cancer therapeutics scarcely reported. This article provides the recent progress in pH and redox-responsive polymer-nano composites for site-specific drug delivery in cancer therapy. It explores design principles, fabrication methods, mechanism of action, and prospects of these dual-stimuli responsive biomaterials.

Preprint ARTICLE | doi:10.20944/preprints202308.0014.v2

Effects of Difluorophenyl Substituents on Structural, Redox, and Magnetic Properties of Blatter Radicals

Dmitry Gulyaev, Andrey Serykh, Evgeny Tretyakov, Anna Akyeva, Mikhail Syroeshkin, Dmitry Gorbunov, Svetlana Maltseva, Nina Gritsan, Galina Romanenko, Artem Bogomyakov

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Blatter radicals; fluorinated organic compounds; electrochemically reversible processes; antiferromagnetically coupled chains; magneto-structural correlations

Online: 2 August 2023 (05:04:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0914.v1

Yerba Maté (Ilex paraguariensis) Supplement Exerts Beneficial, Tissue-Specific Effects on Mitochondrial Efficiency and Redox Status in Healthy Adult Mice

Chase M. Walton, Erin R. Saito, Cali E. Warren, John G. Larsen, Nicole P. Remund, Paul R. Reynolds, Jason M. Hansen, And Benjamin T. Bikman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Yerba Maté; Metabolism; Obesity; Nutraceuticals; Mitochondria

Online: 14 September 2023 (03:32:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1937.v1

Redox Signaling in Endosomes on the Example of EGF Receptors

Dana Maureen Hebchen, Katrin Schröder

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: early endosomes; redoxosomes; trans-activation; EGFR; reactive oxygen species

Online: 25 September 2024 (11:39:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1006.v1

β-cyclodextrin Nanophotosensitizers for Redox-Sensitive Delivery of Chlorin e6

Jaewon Jo, Ji Yoon Kim, Je-Jung Yun, Young Ju Lee, Young-IL Jeong

Subject: Chemistry And Materials Science, Biomaterials Keywords: β-Cyclodextrin; redox-sensitive; cancer targeting; photodynamic therapy; chlorin e6

Online: 17 October 2023 (05:12:13 CEST)

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The aim of this study is to prepare redox-sensitive nanophotosensitizers for targeted delivery of chlorin e6 (Ce6) against cervical cancer. For this purpose, Ce6 was conjugated with β-cyclodextrin (bCD) via disulfide bond creating nanophotosensitizers that were fabricated for redox-sensitive delivery of Ce6 against cancer cells. bCD was treated with succinic anhydride to synthesize suc-cinylated bCD (bCDsu). After that, cystamine was attached to the carboxylic end of bCDsu (bCDsu-ss) and the amine end group of bCDsu-ss was conjugated with Ce6 (bCDsu-ss-Ce6). Chemical composition of bCDsu-ss-Ce6 was confirmed with 1H and 13C NMR spectra. bCDsu-ss-Ce6 nanophotosensitizers were fabricated by dialysis procedure. They formed small particles with an average particle size of 152.0±23.2 nm and they showed improved singlet oxygen (SO) generation in the aqueous solution under light irradiation and was significantly higher than that of Ce6 alone. Ce6 release rate from bCDsu-ss-Ce6 nanophotosensitizers was accelerated by addition of glutathione (GSH), indicating that bCDsu-ss-Ce6 nanophotosensitizers have re-dox-sensitive photosensitizer delivery capacity. bCDsu-ss-Ce6 nanophotosensitizers have low in-trinsic cytotoxicity against CCD986Sk human skin fibroblast cells as well as Ce6 alone. However, bCDsu-ss-Ce6 nanophotosensitizers showed improved Ce6 uptake ratio, higher reactive oxygen species (ROS) production and phototoxicity compared to those of Ce6 alone. GSH addition resulted in higher Ce6 uptake ratio, ROS generation and phototoxicity than those of Ce6 alone, indicating that bCDsu-ss-Ce6 nanophotosensitizers have redox-sensitive biological activity in vitro against HeLa human cervical cancer cells. At tumor xenograft model using HeLa cells, bCDsu-ss-Ce6 nanophotosensitizers efficiently accumulated in the tumor rather than normal organs, i.e. fluores-cence intensity in tumor tissues was significantly higher than those of other organs while Ce6 alone did not specifically target tumor tissue. These results indicated higher anticancer activity of bCDsu-ss-Ce6 nanophotosensitizers, by efficiently inhibiting growth of tumor in in vivo animal tumor xenograft study.

Preprint REVIEW | doi:10.20944/preprints202109.0449.v1

Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?

Lena Palaniyappan, Min Tae M. Park, Peter Jeon, Roberto Limongi, Kun Yang, Akira Sawa, Jean Théberge

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: glutathione; glutamate; psychosis; schizophrenia; redox; antioxidant; oxidative stress; myelin; spectroscopy

Online: 27 September 2021 (12:47:39 CEST)

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Working Paper ARTICLE

Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome

Jason M. Held

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cysteine oxidation redox systems biology proteomics signaling EGFR cryptic

Online: 10 April 2019 (10:07:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0222.v1

Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients

Ewa Ambrożewic, Piotr Wojcik, Adam Wronski, Wojciech Luczaj, Anna Jastrząb, Neven Zarkovic, Elżbieta Skrzydlewska

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: psoriasis, arthritis, inflammation, granulocytes, redox signaling, oxidative stress, lipid peroxidation, 4-hydroxynonenal, lipids, endocannabinoid system

Online: 12 September 2018 (13:43:16 CEST)

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Inflammatory granulocytes are characterized by oxidative burst, which may promote oxidative stress and lipid modification both in affected tissues and on systemic level. On the other hand, redox signaling involving lipid peroxidation products acting as second messengers of free radicals play important, not yet fully understood, roles in pathophysiology of inflammation and various stress-associated disorders. Therefore, the aim of this study was to evaluate the onset of oxidative stress and alterations of enzyme-dependent lipid metabolism resulting from redox imbalance in granulocytes and plasma obtained from patients with psoriasis vulgaris or psoriatic arthritis, in comparison to the healthy subjects. The results obtained revealed enhanced activity of pro-oxidant enzymes NADPH and xanthine oxidases in granulocytes, with a decrease of enzymatic and non-enzymatic antioxidants in plasma of psoriatic patients. The Nrf2 and its regulators were increased in both forms of psoriasis, while HO-1 levels were increased only in psoriasis vulgaris. Redox imbalance was associated with decreased levels of phospholipids and of free PUFAs, but with enhanced activity of enzymes involved in lipid metabolism (PLA2, PAF-AH COX1/2) and increased lipid peroxidation products 4-hydroxynonenal (4-HNE), isoprostanes and neuroprostanes. Increased endocannabinoids and GPR55 were observed in both forms of the disease, while expression of CB1 was increased only in pateints with psoriatic arthritis, opposite to CB2, which was increased only in psoriasis vulgaris. Protein modifications by ROS and lipid peroxidation product 4-HNE promoted apoptosis of granulocytes by increased caspases in both forms of psoriasis. This study indicates that excessive activation of granulocytes, causing oxidative stress and lipid modifications, is an important pathophysiology of psoriasis. Consequently, lower Nrf2 activity and CB2 expression may promote progression of psoriasis into advanced, arthritic form of the disease.

Preprint REVIEW | doi:10.20944/preprints202306.0070.v1

Exploring the Interplay Between Polyphenols and Lysyl Oxidase Enzymes for Maintaining Extracellular Matrix Homeostasis

Carolina Añazco, Janin Riedelsberger, Lorenzo Vega-Montoto, Armando Rojas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Collagen Cross-linking; Extracellular Matrix; Fibrosis; Glycation; Lysyl Oxidase; Polyphenols

Online: 1 June 2023 (08:46:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0137.v1

Effect of 5-Azacitine Treatment on Redox Status and Inflammatory Condition in MDS Patients

Paola Montes, Ana Guerra-Librero, Paloma García, Mª Elena Cornejo-Calvo, Mª del Señor López, Tomás de Haro, Laura Martínez-Ruiz, Germaine Escames, Darío Acuña-Castroviejo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: myelodysplastic syndrome (MDS); oxidative stress; cytokines; inflammation; 5-Azacitidine; somatic alterations

Online: 8 December 2021 (14:36:28 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints201904.0210.v2

Hypothesis: Chemical Activity Regulates and Coordinates the Process Maintaining Glycerophospholipid Homeostasis in Mammalian Cells.

Pentti Somerharju, Jorma A. Virtanen, Martin Hermansson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: regulation; membrane; glycerophospholipid; composition; chemical activity

Online: 31 October 2019 (04:39:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.0695.v1

An Alternate Perspective on Cancer Immunology: The Protein-Homeostasis-System Hypothesis

Jung-Woo Rhim, Kyung-Yil Lee

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: cancer theories; oncogenesis; carcinogenesis; cancer immunology; T cell-based immunotherapy; protein-homeostasis-system hypothesis

Online: 9 July 2024 (07:00:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0776.v1

Redox Modulatory Potential of Methanol Extract of Pentaclethra Macrophylla Stem Bark

Petra Obioma Nnamani, Edith Obioma Diovu, Peter Ikechukwu, Akachukwu M Onwuka, Obiora Emmanuel Abonyi, Obinna Chibueze Ibezim, Birgitta Loretz, Mariia Nesterkina, Claus- Michael Lehr

Subject: Medicine And Pharmacology, Pharmacy Keywords: Pentaclethera macrophylla stem bark; Methanol extract; Bergenin; Acute toxicity; Antioxidant; DPPH.

Online: 12 July 2023 (08:56:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1708.v1

Cytoplasmic Membrane Homeostasis is Important for the Pathogenicity of Pathogenic Fungi

Yuejin Peng, Bin Chen

Subject: Biology And Life Sciences, Life Sciences Keywords: Cytoplasmic membrane homeostasis; Pathogenicity; Pathogenic fungi; Membrane lipid metabolism; Membrane curvature; Transmembrane protein; Cell wall components; Cytoskeleton; Growth and development; Host infection

Online: 24 May 2023 (10:38:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0031.v1

Direct Electron Transfer-type Bioelectrocatalysis of Redox Enzymes at Nanostructured Electrodes

Taiki Adachi, Yuki Kitazumi, Osamu Shirai, Kenji Kano

Subject: Chemistry And Materials Science, Electrochemistry Keywords: direct-electron transfer-type bioelectrocatalysis; nanostructures; mesoporous electrodes, curvature effect; protein engineering; bi-directional bioelectrocatalysis; hydrogenase; fructose dehydrogenase; bilirubin oxidase; formate dehydrogenase; ferredoxin-NADP+ reductase

Online: 3 February 2020 (13:34:02 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0237.v1

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

Wiebke Nadolni, Susanna Zierler

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: TRPM7, kinase, inflammation, lymphocytes, calcium signalling, SMAD, TH17, hypersensitivity, regulatory T cells, thrombosis, graft versus host disease, T cells, innate immunity

Online: 13 July 2018 (14:14:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1398.v1

Sensory Properties, Redox Characteristics, and Impact on the Hemodynamics of the Flavanol-Rich Fraction Originated Grape and Blueberry

Naomi Osakabe, Toshihiko Shoji, Kurumi Onishi, Chie Hirahata, Kento Hiroki, Taiki Fushimi, Yasuyuki Fujii, Ursula Jacob, Ali Abdelhameed, Rosanna Di Paola, Salvatore Cuzzocrea, Vittorio Calabrese

Subject: Medicine And Pharmacology, Other Keywords: flavanol; astringency; O2･-; blood flow; sympathetic nerve

Online: 23 March 2024 (09:38:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.1016.v1

Nutraceuticals Modulating Mitophagy May Combat the Mitochondrial Dysfunction and Redox Stress in Several Cardiac Disorders

Moeka Nakashima, Naoko Suga, Satoru Matsuda

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: autophagy; mitophagy; AMPK; cardiomyocyte; cardiac arrhythmia; cardiovascular disease; cardiac failure

Online: 16 April 2024 (16:27:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0219.v1

Understanding the Heterogeneity of Human Pericyte Subsets in Blood-Brain Barrier Homeostasis and Neurological Diseases

Diana Bohannon, Danielle Long, Woong-Ki Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s disease; blood-brain barrier; endothelial cell; laminin; multiple sclerosis; pericyte; perivascular macrophage; sonic hedgehog; vascular smooth muscle cell

Online: 8 March 2021 (13:35:25 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202005.0177.v1

Interference of SARS-CoV-2 with the Homeostasis of Ventilation and Perfusion in the Lung

Clemente F. Arias, Francisco J. Acosta, Federica Bertocchini, Cristina Fernández-Arias

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: SARS-CoV-2; COVID-19; homeostasis; hypoxic pulmonary vasoconstriction; renin-angiotensin system; hydrostatic edema; permeability edema

Online: 10 May 2020 (17:22:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0356.v1

Redox Regulation of PTEN by Reactive Oxygen Species: Role in Physiological Processes

Vu Hoang Trinh, Thang Huu Nguyen, Dhiraj Kumar Sah, Jin Myung Choi, Hyun Joong Yoon, Sang Chul Park, Yu Seok Jung, Seung-Rock Lee

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: PTEN; redox regulation; oxidative inhibition; ROS; cell signaling

Online: 5 January 2024 (02:00:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1799.v2

QTL Epistasis Plays a Role of Homeostasis on Heading Date in Rice

Lilong Huang, Jichun Tang, Bihuang Zhu, Guodong Chen, Leyi Chen, Suhong Bu, Haitao Zhu, Zupei Liu, Zhan Li, Lijun Meng, Guifu Liu, Shaokui Wang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Epistasis; Homeostasis; Single segment substitution line; Heading date; Rice

Online: 31 July 2023 (09:42:16 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202109.0530.v1

Energy Homeostasis Principle: A Naturalistic Approach to Explain the Emergence of Behavior

Sergio Vicencio, Mario Villalobos, Pedro Maldonado, Rodrigo Vergara

Subject: Biology And Life Sciences, Other Keywords: energy; homeostasis; neural network; behavior; free energy principle

Online: 30 September 2021 (17:49:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0244.v1

Cofactor F₄₂₀-Dependent Enzymes: An Under-Explored Resource for Asymmetric Redox Biocatalysis

Mihir V. Shah, James Antoney, Suk Woo Kang, Andrew C. Warden, Carol J. Hartley, Hadi Nazem-Bokaee, Colin J. Jackson, Colin Scott

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: cofactor F420; deazaflavin; oxidoreductase; hydride transfer; hydrogenation; asymmetric synthesis; cofactor biosynthesis

Online: 21 September 2019 (01:28:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.0346.v1

Subepithelial Stromal Cells: Their Roles and Interactions with Intestinal Epithelial Cells during Gut Mucosal Homeostasis and Regeneration

Hammed Ayansola, Edith J Mayorga, Younggeon Jin

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Intestinal stem cell niche; mesenchymal stromal cells; sub-epithelial gradient factors; epithelial-mesenchymal interactions

Online: 6 February 2024 (09:40:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.0098.v2

Therapeutic Potential of Heterocyclic Compounds Targeting Mitochondrial Calcium Homeostasis and Signaling in Alzheimer’s Disease and Parkinson’s Disease

Victor Tapias, Paula González-Andrés, Laura F. Peña, Asunción Barbero, Lucía Núñez, Carlos Villalobos

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; Parkinson’s disease; mitochondria; oxidative stress; calcium; heterocyclic compounds

Online: 17 May 2023 (14:13:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1200.v1

Antioxidant Defense and Ionic Homeostasis Govern Stage-Specific Response of Salinity Stress in Contrasting Rice Varieties

Vikash Kumar, Ashish Kumar Srivastava, Deepak Sharma, Shailaja P Pandey, Manish Pandey, Ayushi Dudwadkar, Harshala J Parab, Penna Suprasanna, Bikram Kishore Das

Subject: Biology And Life Sciences, Plant Sciences Keywords: Rice; Salt Stress; Stage-specific salinity; Antioxidant defense; Ionic homeostasis; Salt tolerance

Online: 16 January 2024 (06:55:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1010.v1

Sensory Nutrition and Polyphenols; Regulation of Homeostasis through Chemosensory Receptor Interaction with Bitter or Astringent Taste

Naomi Osakabe, Takafumi Shimizu, Yasuyuki Fujii, Taiki Fushimi, Vittorio Calabrese

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Polyphenol; sensory nutrition; bitter; astringency; central nervous system

Online: 12 January 2024 (11:27:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0769.v1

The Mechanisms of Molybdate Distribution and Homeostasis with Special Focus on the Model Plant Arabidopsis thaliana

Jan-Niklas Weber, Rieke Minner-Meinen, David Kaufholdt

Subject: Biology And Life Sciences, Plant Sciences Keywords: Molybdate Transporters; Metal homeostasis in plants; Molybdate distribution; Molybdenum Cofactor; Arabidopsis thaliana

Online: 12 October 2023 (04:44:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2076.v1

The Rationale for Sulforaphane to Favourably Influence Gut Homeostasis and Gut-Organ Dysfunction: a Clinician’s Hypothesis

Christine A. Houghton

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: sulforaphane; gut-organ axis; gut ecology; microbiome; chronic disease; nutrigenomics; nutritional medicine; food intolerance; epithelium, dysbiosis; gut barrier

Online: 29 June 2023 (08:06:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0191.v1

Physiological and Transcriptional Analyses Provide Insight Into Maintaining Ion Homeostasis of Sweet Sorghum Under Salt Stress

Huan Guo, Chun-Ya Nie, Zhen Li, Jie Kang, Xiao-Long Wang, Yan-Nong Cui

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: soil salinity; sodium; chloride; ion transporters; transcriptome factors

Online: 2 June 2023 (11:34:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0006.v1

Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain

Artem V. Artiukhov, Vasily A. Aleshin, Irina S. Karlina, Alexey V. Kazantsev, Daria A. Sibiryakina, Alexander L. Ksenofontov, Nikolay V. Lukashev, Anastasia V. Graf, Victoria I. Bunik

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: branched chain 2-oxo acids; 2-oxoglutarate dehydrogenase; pyruvate dehydrogenase; phospho-nate and phosphinate analogs of pyruvate; protein succinylation; protein acetylation; protein glutarylation; sirtuin 3; sirtuin 5; anxiety

Online: 3 October 2022 (12:11:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0009.v1

How Smell Regulates Metabolism: The Role Of Ectopically Expressed Olfactory Receptors In Lipid and Glucose Homeostasis

Ginevra Urbani, Eleonora Distrutti, Michele Biagioli, Silvia Marchianò, Stefano Fiorucci

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: olfactory receptors; glucose metabolism; type 2 diabetes mellitus; lipid metabolism; NAFLD; metabolic syndrome

Online: 2 April 2022 (09:00:47 CEST)

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