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Preprint REVIEW | doi:10.20944/preprints202008.0094.v1

Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection

Chung-Yang Yeh, Anthony Schulien, Bradley Molyneaux, Elias Aizenman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Ischemic Stroke; Reperfusion; Neuroprotection; Nerinetide; Kv2.1

Online: 4 August 2020 (11:28:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1751.v1

Antioxidant Activity of Planar Catechin Conjugated with Trolox

Wakana Shimizu, Yoshimi Shoji, Kei Ohkubo, Hiromu Ito, Ikuo Nakanishi, Kiyoshi Fukuhara

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: catechin; trolox; tocopherol; antioxidant activity

Online: 23 August 2024 (17:13:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0776.v1

Redox Modulatory Potential of Methanol Extract of Pentaclethra Macrophylla Stem Bark

Petra Obioma Nnamani, Edith Obioma Diovu, Peter Ikechukwu, Akachukwu M Onwuka, Obiora Emmanuel Abonyi, Obinna Chibueze Ibezim, Birgitta Loretz, Mariia Nesterkina, Claus- Michael Lehr

Subject: Medicine And Pharmacology, Pharmacy Keywords: Pentaclethera macrophylla stem bark; Methanol extract; Bergenin; Acute toxicity; Antioxidant; DPPH.

Online: 12 July 2023 (08:56:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0506.v1

Redox Regulation of LAT Enhances T Cell-Mediated Inflammation

Jaime James, Ana Coelho, Gonzalo Fernandez Lahore, Clara Marquina Hernandez, Florian Forster, Bernard Malissen, Rikard Holmdahl

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: NCF1; Reactive Oxygen Species; Linker for Activation of T cells; T cell receptor signaling; Rheumatoid Arthritis

Online: 8 March 2024 (11:03:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0043.v1

The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction

Hilary Y. Liu, Jenna R. Gale, Ian J. Reynolds, John H. Weiss, Elias Aizenman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: zinc, mitochondria, neurodegeneration, calcium, energy metabolism, mitochondrial dynamics

Online: 2 March 2021 (09:03:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0122.v2

Novel NH4V4O10-Reduced Graphene Oxide Cathodes for Zinc-Ion Batteries: Theoretical Predictions and Experimental Validation

He Lin, Chenfan Liu, Yu Zhang

Subject: Chemistry And Materials Science, Electrochemistry Keywords: zinc-ion batteries; cathode materials; NH4V4O10; reduced graphene oxide

Online: 24 June 2024 (13:52:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0392.v1

Hydrogen Peroxide and Redox Regulation of Development

Christine Rampon, Michel Volovitch, Alain Joliot, Sophie Vriz

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: H2O2, redox signalling, development, regeneration, adult stem cells, metazoan

Online: 19 September 2018 (21:42:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0029.v1

Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review.

Renate Viebahn-Haensler, Olga León Fernández

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: redox bioregulation; mitochondriopathies; low-dose ozone concept; ozone therapy; oxidative stress; antioxidant capacity

Online: 1 May 2024 (07:29:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0824.v1

Building Up a Human Ovarian Antioxidant ceRNA Network, OvAnOx: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and Dysfunctions

Carla Tatone, Giovanna Di Emidio, Rosalia Battaglia, Cinzia Di Pietro

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: ceRNA network; oxidative stress; female fertility; antioxidant cell defence; non-coding RNAs

Online: 12 August 2024 (14:02:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0648.v1

Enhancing Polysulfide Redox Kinetics Through Synergistic Polarization of Ferroelectric (Ba0.9Sr0.1TiO3) Nanoparticles for High-Capacity Li-S Batteries.

Ivan Castillo, Balram Tripathi, Danilo Barrionuevo, Karuna K. Mishra, Gerardo Morell, Ram S. Katiyar

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: Li-S battery; C/S composite; BST coupling; polysulfide trapping; ferroelectric material

Online: 9 August 2024 (12:09:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1649.v2

Phylogenetic Analysis of Pyruvate-Ferredoxin Oxidoreductase, a Redox Enzyme Involved in the Activation of Nitro-Based Prodrugs in Bacteria and Protozoa

Seth Duwor, Daniela Brites, Pascal Mäser

Subject: Biology And Life Sciences, Life Sciences Keywords: Pyruvate-ferredoxin oxidoreductase; metronidazole; reductive bioactivation; antimicrobial spectrum; comparative genomics; horizontal gene transfer ;

Online: 1 March 2024 (07:57:55 CET)

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Simple Summary: The distribution of typical bacterial redox enzymes such as pyruvate-ferredoxin oxidoreductase (PFOR) in protozoa remains interestingly puzzling. Previous studies have demonstrated diverse cellular localizations of PFOR in some amitochondriate anaerobic protozoa. PFOR is of particular pharmacological importance because it catalyzes the reductive bio-activation of nitro-based prodrugs to cytotoxic radical metabolites. Metronidazole was developed primarily as an antiprotozoal agent against infections caused by Trichomonas vaginalis. However, its antimicrobial spectrum was subsequently expanded to cover anaerobic bacterial infections. It has been shown that mutations in the genes encoding PFOR result in inherent resistance of PFOR-possessing anaerobic protozoa and bacteria to nitro-based prodrugs. Deciphering the evolutionary history of PFOR is crucial in deepening our understanding of the evolution of anaerobic pathogens and unfold new approaches for drug discovery and targeting in pathogen chemotherapy. Abstract: The present frontrunners in the chemotherapy of infections caused by protozoa are nitro-based prodrugs that are selectively activated by PFOR-mediated redox reactions. This study seeks to analyze the distribution of PFOR in selected protozoa and bacteria by applying comparative bioinformatics approaches to test the hypothesis that PFOR was most likely acquired through horizontal gene transfer (HGT) from bacteria. Furthermore, to identify other genes that were putatively acquired using proteome-wide and gene expression analyses. A plausible explanation for the patchy occurrence of PFOR in protozoa is based on the hypothesis that bacteria are potential sources of genes that enhance optimal adaptation of protozoa in hostile environments. The exclusively expressed proteins obtained from Entamoeba histolytica and the putative gene donor, Desulfovibrio vulgaris, showed an over-expression of eleven genes involved in intermediary metabolism. If these results can be reproduced in other PFOR-possessing protozoa, it would provide a more validated evidence to support the horizontal transfer of pfor from bacteria.

Preprint ARTICLE | doi:10.20944/preprints202307.1684.v1

Redox Metabolism and Vascular Calcification in Chronic-Kidney Disease

Cristina Alonso-Montes, Natalia Carrillo-López, Sara Panizo, Beatriz Martín-Carro, Juan Carlos Mayo Barrallo, Pablo Román-García, Raúl García-Castro, Jesús M. Fernández-Gómez, Miguel A. Hevia-Suárez, Julia Martín-Vírgala, Sara Fernández-Villabrille, Laura Martínez-Arias, Sara Barrio Vázquez, Laura Calleros Basilio, Jorge Benito Cannata-Andía, Manuel Naves-Díaz, José Luis Fernández-Martín, Isabel Quirós-González

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Vascular calcification; Catalase; CKD; RUNX2; Epigastric arteries; DIGE

Online: 26 July 2023 (02:38:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0107.v1

Thioredoxins o1 and h2 Show Different Subcellular Localizations and Redox-Active Functions, but Cooperatively Affect NADPH Redox Poise and Photosynthetic Performance in Fluctuating Light

Liang-Yu Hou, Martin Lehmann, Peter Geigenberger

Subject: Biology And Life Sciences, Plant Sciences Keywords: Trx o1; Trx h2; metabolomics; ascorbate; glutathione; NAD(P)(H); photosynthetic performance; fluctuating light; Arabidopsis thaliana

Online: 2 March 2021 (16:19:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0180.v2

Redox Homeostasis and Nitro-Oxidative Stress in Obesity-Linked Inflammation

Guillaume Treiber, Hanen Samouda, Estelle Nobécourt, Serge P. Bottari

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: oxidative stress; nitrative stress; reactive oxygen species; reactive nitrogen species; nitric oxide inflammation; obesity; peroxynitrite; adipose tissue

Online: 30 September 2022 (11:10:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0024.v1

The Writers, Readers and Erasers in Redox Regulation of GAPDH

Maria Tossounian, Bruce Zhang, Ivan Gout

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: GAPDH; metabolism; moonlighting protein; redox regulation; oxidative PTMs; S-thiolation

Online: 1 December 2020 (13:14:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0019.v1

Techno-Economic Modeling and Analysis of Redox Flow Battery Systems

Jens Noack, Lars Wietschel, Nataliya Roznyatovskaya, Karsten Pinkwart, Jens Tübke

Subject: Engineering, Energy And Fuel Technology Keywords: redox flow battery; techno-economic analysis; materials; cost

Online: 2 August 2016 (11:41:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0737.v3

Monitoring the Redox Status in Multiple Sclerosis

Masaru Tanaka, László Vécsei

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: oxidative stress; redox; antioxidant; multiple sclerosis; biomarker; neurodegenerative disease; personalized medicine

Online: 22 September 2020 (08:42:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1238.v1

Plasma Redox Balance in Advanced Maternal Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

Elena Grossini, Carmen Imma Aquino, Sakthipriyan Venkatesan, Libera Troia, Eleonora Tizzoni, Federica Fumagalli, Daniela Ferrante, Rosanna Vaschetto, Valentino Remorgida, Daniela Surico

Subject: Medicine And Pharmacology, Reproductive Medicine Keywords: aging; antioxidants; lipid peroxidation; nitric oxide; pregnancy

Online: 20 March 2024 (16:56:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0390.v1

Redox Metabolism Measurement in Mammalian Cells and Tissues by LC-MS

Naama Kanarek, Boryana Petrova, Anna Warren, Nuria Yulia Vital, Adam G Maynard, Alan Wong

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: redox metabolites; mass-spectrometry method; HILIC chromatography; NADH; NADPH; Glutathione; redox metabolite detection in mammalian cells

Online: 14 April 2021 (16:09:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0525.v2

4-Hydroxynonenal in Redox Homeostasis of Gastrointestinal Mucosa: implications for Stomach in Health and Diseases

Andriy Cherkas, Neven Zarkovic

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: 4-Hydroxynonenal; lipid peroxidation; redox balance; oxidative stress; stomach; peptic ulcer; gastritis; Helicobacter pylori; gastric cancer; non-steroid anti-inflammatory drugs-induced gastropathy

Online: 23 August 2018 (04:24:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0003.v1

Human Milk Redox Homeostasis: The Gestational Pathologies Effect

Chiara Peila, Lorenzo Riboldi, Elena Spada, Alessandra Coscia, Ignazio Barbagallo, Giovanni Livolti, Fabio Galvano, Diego Gazzolo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Human milk; breastfeeding; GSH; LOOHs; preeclampsia; gestational diabetes mellitus; newborn nutrition

Online: 1 September 2023 (13:45:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0379.v1

Mass Transport Optimization for Redox Flow Battery Design

Nicholas Gurieff, Declan Finn Keogh, Mark Bladry, Victoria Timchenko, Donna Green, Ilpo Koskinen, Chris Menictas

Subject: Engineering, Energy And Fuel Technology Keywords: vanadium redox flow battery; power density; limiting current; cell geometry; mass transfer; electrolyte mixing; static mixer; industrial design; multidisciplinary research; energy transitions

Online: 26 March 2020 (01:51:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0656.v1

Biocontrol Potential of Trichoderma asperellum CMT10 Against Strawberry Root Rot Disease

Ping Liu, Rui Xian Yang, Zu Hua Wang, Yin Hao Ma, Wei Guang Ren, Dao Wei Wei, Wen Yu Ye

Subject: Biology And Life Sciences, Horticulture Keywords: Strawberry root rot; Trichoderma asperellum; biocontrol mechanism; biocontrol efficacy; growth-promoting effect

Online: 14 February 2024 (03:51:50 CET)

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Strawberry root rot caused by Neopestalotiopsis clavispora is one of the main diseases of strawberry and significantly impacts the yield and quality of strawberry fruit. There are now no effective control techniques available except for fungicide sprays, which may directly impact consumers. Biological control is becoming an alternative method for the control of plant diseases to replace or decrease the application of traditional synthetic chemical fungicides. Trichoderma is widely used as a biological agent for controlling strawberry root rot. In order to provide resources for screening the highly effective biocontrol fungus for controlling strawberry root rot caused by Neopestalotiopsis clavispora, the biocontrol mechanism,the control effects of Trichoderma asperellum CMT10 against strawberry root rot and growth-promoting effects on strawberry seedlings were investigated by plate culture, microscopy observation and root drenching methods.The results showed that CMT10 had obvious competitive, antibiotic and hyperparasitism effects on Neopestalotiopsis clavispora CMGF3. The CMT10 could quickly occupy nutritional space, and the inhibition rates of CMT10 against CMGF3 in confrontation culture on 7 d was 65.49%. The inhibition rates of volatile metabolite and fermentation metabolite produced by CMT10 against CMGF3 were 79.67% and 69.84%, respectively. The mycelium of strain CMT10 can act as hyperparasites by making contacting, winding and penetrating hyphae of CMGF3. Pot experiment showed that the biocontrol efficacy of CMT10 on strawberry root rot caused by Neopestalotiopsis clavispora was 63.00%. CMT10 had obvious promotion effect on strawberry growth, the plant height, root length, total fresh weight, root fresh weight, stem fresh weight and root dry weight, with the promotion rates were 20.09%, 22.39%, 87.11%, 101.58%, 79.82% and 72.33%, respectively. Overall, this study showed the ability of Trichoderma asperellum CMT10 to control strawberry root rot and their potential to develop as novel biocontrol agents to replace chemical fungicides for eco-friendly, sustainable agriculture.

Preprint HYPOTHESIS | doi:10.20944/preprints202305.1129.v1

Lymphatics — Future Perspectives Unrealized Potential

Philip David Houck, Hari function and Dandapantula, Janet Massey

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Lymphangiontrope; salt sensitivity; cardiorenal syndrome; SGLT2 inhibitors; Down’s syndrome; depression; schizophrenia; C Reactive Protein

Online: 16 May 2023 (08:51:13 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0408.v1

Redox Regulation of PTEN by Bicarbonate and Hydrogen Peroxide: Implication of Peroxymonocarbonate

Vu Hoang Trinh, Jin Myung Choi, Thang Nguyen Huu, Dhiraj Kumar Sah, Hyun Joong Yoon, Sang Chul Park, Yu Seok Jung, Youngkeun Ahn, Seung-Rock Lee

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: PTEN; redox regulation; H2O2; bicarbonate; peroxymonocarbonate.; cell signaling

Online: 7 February 2024 (06:02:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0046.v1

Hydroxyhydroquinone and Quassinoids as Promising Compounds with Hypoglycemic Activity through Redox Balance

Paulo Roberto dos Santos, Sidineia Danetti, Joseph Rastegar, Wellington De Souza, Rafaele Frassini, Fernando Joel Scariot, Sidnei Moura, Mariana Roesch-Ely

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: hydroxyhydroquinone; quassinoids; glycemia

Online: 2 August 2023 (05:20:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1589.v1

Are Protein Cavities and Pockets Commonly Used by Redox Active Signalling Molecules?

John T. Hancock

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: argon; hydrogen peroxide; hydrogen sulfide; hydroxyl radicals; molecular hydrogen; nitric oxide; peroxynitrite; protein cavities; superoxide; xenon

Online: 23 May 2023 (07:12:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0344.v1

Redox Regulation and Oxidative Stress: The Particular Case of the Stallion Spermatozoa

Fernando Juan Peña Vega, Cristian O'Flaherty, Jose M. Ortiz Rodríguez, Francisco E. Martín Cano, Gemma L. Gaitskell-Phillips, María C. Gil, Cristina Ortega Ferrusola

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: horses; spermatozoa; ROS; oxidative stress; redox regulation; equine

Online: 30 September 2019 (08:06:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0171.v1

Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity, and Aging

Collin Y. Ewald

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: NOX, sulfenylation, Nrf2, SKN-1, centenarians, extracellular matrix, longevity

Online: 10 September 2018 (12:59:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0103.v1

Machine Learning Prediction of the Redox Activity of Quinones

Ilia Kichev, Lyuben Borislavov, Alia Tadjer, Radostina Stoyanova

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: quinones; machine learning; ridge regression; decision tree; ensemble methods; density functional theory; organic electrode materials

Online: 3 October 2023 (09:14:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0511.v1

Looking Back at the Early Times of Redox Biology

Leopold Flohe

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Ferroptosis; glutathione peroxidases; heme peroxidases; hydrogen peroxide; lipid peroxidation; nitrogen monoxide radical; superoxide dismutase; superoxide radical; thioredoxin

Online: 26 October 2020 (10:43:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1307.v1

Characterization of Nutritional Potential of Amaranthus sp. Grain Production

Alexandru Mătieș, Cornel Negrușier, Oana Roșca Mare, Olimpia Smaranda Mintaș, Gabriela Zanc (Săvan), Antonia Cristina Maria Odagiu, Luiza Andronie, Ioan Păcurar

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: morpho-productive traits; correlations; food; seed

Online: 23 February 2024 (10:33:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.0549.v1

Methodological Approaches to Experimental Evaluation of Neuroprotective Action of Potential Drugs

Igor Belenichev, Nina Bukhtiyarova, Victor Ryzhenko, Lyudmyla Makyeyeva, Oksana Morozova, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: ischemic stroke; models of cerebral ischemia; neuroprotection; drug effect

Online: 6 September 2024 (16:47:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0958.v1

Unlocking the Potential of Mannosylerythritol Lipids: Properties and Industrial Applications

Joana Dias de Almeida, Miguel Figueiredo Nascimento, Petar Kekovic, Frederico Castelo Ferreira, Nuno Torres Faria

Subject: Engineering, Bioengineering Keywords: Mannosylerythritol lipids; Glycolipids; Biosurfactants; Cosmetics; Biomedical; Food; Bioremediation

Online: 15 April 2024 (13:55:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1263.v1

Metabolic and Functional Interaction of H₂S and Sucrose in Maize Thermotolerance through Redox Homeodynamics

Xiao-Er Li, Hong-Dan Zhou, Zhong-Guang Li

Subject: Biology And Life Sciences, Plant Sciences Keywords: Hydrogen sulfide; maize seedlings; redox homeodynamics; sucrose signaling; thermotoleranceugh MG-scavenging system; Calcium; Maize seedling; Methylglyoxal; Methylglyoxal-scavenging system; Thermotolerance

Online: 20 May 2024 (09:51:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0203.v1

Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer

Adrian I Abdo, Zlatko Kopecki

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cold plasma; plasma-activated water; redox signalling; cancer; wound healing; Nrf2; MAPK; PI3K/Akt; endoplasmic reticulum stress

Online: 2 April 2024 (12:22:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0107.v1

On the Redox-Activity and Health-Effects of Atmospheric Primary and Secondary Aerosol: Phenomenology

Francesca Costabile, Stefano Decesari, Roberta Vecchi, Franco Lucarelli, Gabriele Curci, Dario Massabò, Matteo Rinaldi, Maurizio Gualtieri, Emanuela Corsini, Elena Menegola, Silvia Canepari, Lorenzo Massimi, Stefania Argentini, Maurizio Busetto, Gianluca Di Iulio, Luca Di Liberto, Marco Paglione, Igor Petenko, Mara Russo, Angela Marinoni, Gianpietro Casasanta, Sara Valentini, Vera Bernardoni, Federica Crova, Gianluigi Valli, Alice Corina Forello, Fabio Giardi, Silvia Nava, Giulia Pazzi, Paolo Prati, Virginia Vernocchi, Teresa La Torretta, Ettore Petralia, Milena Stracquadanio, Gabriele Zanini, Gloria Melzi, Emma Nozza, Martina Iulini, Donatella Caruso, Lucia Cioffi, Gabriele Imperato, Flavio Giavarini, Maria Battistoni, Francesca Di Renzo, Maria Agostina Frezzini, Cinzia Perrino, Maria Cristina Facchini

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: atmospheric aerosol; chemical composition; secondary aerosol; source apportionment; ultrafine particles; oxidative potential; exposure; toxicology; forecasting; micrometeorology

Online: 12 April 2022 (09:54:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0826.v1

Potential Regulation of Iron Metabolism Gene Expression by DOF Transcription Factors in Dendrocalamus latiflorus

Peng-Kai Zhu, Mei-Xia Lin, Mei-Yin Zeng, Yu Tang, Xin-Rui Li, Tian-You He, Yu-Shan Zheng, Ling-Yan Chen

Subject: Biology And Life Sciences, Plant Sciences Keywords: DOF transcription factors; Iron Metabolism Related Genes; gene regulation; gene expression; Dendrocalamus latiflorus

Online: 10 July 2024 (10:14:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0070.v1

Recent Advances in “pH and Redox Responsive Polymer-Nano- Composites for Cancer Therapy

Shivalingayya Gaddimath, Shivanand Payamalle, Keshavananda Prabhu CP, Jaehyun Hur

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: cancer; biological thiols; stimuli responsive; cancer therapeutics

Online: 4 December 2023 (02:26:05 CET)

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In recent years, cancer therapy has witnessed significant advancements, with a focus on personalized and targeted treatment strategies. One promising approach involves the use of stimuli-responsive biomaterials for site-specific drug release. Among these biomaterials, pH, and redox-triggered polymer-nano composites have gained immense attention due to their ability to respond to the specific tumor microenvironment, enhancing therapeutic efficacy while reducing off-target effects. Cancer cells often exhibit anomalous biochemical properties, attributed to lower cytosolic pH (acidic) and elevated redox potential through the epitomized upregulation of undesired genes. Such biological process substantially imbalance the level ions (protons) and biological thiols glutathione (GHS) in the cytoplasm as well as in the subcellular organelles. Superfluous accumulation of ions and redox imbalance is associated with proliferation, invasion, and growth of tumor. Because of high surface area, deep tissue penetration capability, higher hydrophilicity, hydrophobic interior for drug/gene efficient loading, biocompatibility and site-specific targeting efficiency, functionalized polymer nanocomposites are superior to conventional small molecular materials. Paradoxically conventional methods of drug delivery aided therapeutics accompanied with inherent drug/genes are encapsulated in biocompatible carrier or suitable transfecting agents generally suffered with low bioavailability, uncontrolled drug release, low cellular penetration, cellular internalization, toxicity, and poor drug loading efficiency. To overcome these issues, recently various multifunctional nanomaterials were developed, based on synergistic stimuli responsive aided drug release in a specified cellular or subcellular system. High therapeutic efficacy, of nanoparticles (NPs) mainly associated with surface functionalization through biocompatible polymeric materials, site-specific targeting units accompanied with stimuli responsive components. Followed by therapeutically important drug or genetic materials were loaded into NPs either in covalent or non-covalent approach. Intriguingly, combined pH and redox dual stimuli based functional materials specially based on polymeric nanocomposites for cancer therapeutics scarcely reported. This article provides the recent progress in pH and redox-responsive polymer-nano composites for site-specific drug delivery in cancer therapy. It explores design principles, fabrication methods, mechanism of action, and prospects of these dual-stimuli responsive biomaterials.

Preprint ARTICLE | doi:10.20944/preprints202308.0014.v2

Effects of Difluorophenyl Substituents on Structural, Redox, and Magnetic Properties of Blatter Radicals

Dmitry Gulyaev, Andrey Serykh, Evgeny Tretyakov, Anna Akyeva, Mikhail Syroeshkin, Dmitry Gorbunov, Svetlana Maltseva, Nina Gritsan, Galina Romanenko, Artem Bogomyakov

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Blatter radicals; fluorinated organic compounds; electrochemically reversible processes; antiferromagnetically coupled chains; magneto-structural correlations

Online: 2 August 2023 (05:04:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0914.v1

Yerba Maté (Ilex paraguariensis) Supplement Exerts Beneficial, Tissue-Specific Effects on Mitochondrial Efficiency and Redox Status in Healthy Adult Mice

Chase M. Walton, Erin R. Saito, Cali E. Warren, John G. Larsen, Nicole P. Remund, Paul R. Reynolds, Jason M. Hansen, And Benjamin T. Bikman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Yerba Maté; Metabolism; Obesity; Nutraceuticals; Mitochondria

Online: 14 September 2023 (03:32:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1229.v1

Regenerative Potential of Demineralized Dentin-Derived Graft Material in Rabbit Calvaria: A Histomorphometric Study

Bounghoon Lee, Hyunsuk Choi, Dong-Seok Sohn

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: guided bone regeneration; rabbit calvaria; histology; dentin-derived matrix

Online: 20 May 2024 (15:59:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1421.v1

Healing Potential of the Marine Polysaccharides Carrageenan and Ulvan on Second Degree Burns

Dimitra Statha, Asimina Papaioannou, Stefanos Kikionis, Maria Kostaki, Ioannis Sfiniadakis, Andreas Vitsos, Jane Anastassopoulou, Efstathia Ioannou, Vassilios Roussis, Michail Christou Rallis

Subject: Medicine And Pharmacology, Dermatology Keywords: second-degree burn; mice; carrageenan; ulvan; wound healing

Online: 25 March 2024 (09:06:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.1937.v1

Redox Signaling in Endosomes on the Example of EGF Receptors

Dana Maureen Hebchen, Katrin Schröder

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: early endosomes; redoxosomes; trans-activation; EGFR; reactive oxygen species

Online: 25 September 2024 (11:39:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1006.v1

β-cyclodextrin Nanophotosensitizers for Redox-Sensitive Delivery of Chlorin e6

Jaewon Jo, Ji Yoon Kim, Je-Jung Yun, Young Ju Lee, Young-IL Jeong

Subject: Chemistry And Materials Science, Biomaterials Keywords: β-Cyclodextrin; redox-sensitive; cancer targeting; photodynamic therapy; chlorin e6

Online: 17 October 2023 (05:12:13 CEST)

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The aim of this study is to prepare redox-sensitive nanophotosensitizers for targeted delivery of chlorin e6 (Ce6) against cervical cancer. For this purpose, Ce6 was conjugated with β-cyclodextrin (bCD) via disulfide bond creating nanophotosensitizers that were fabricated for redox-sensitive delivery of Ce6 against cancer cells. bCD was treated with succinic anhydride to synthesize suc-cinylated bCD (bCDsu). After that, cystamine was attached to the carboxylic end of bCDsu (bCDsu-ss) and the amine end group of bCDsu-ss was conjugated with Ce6 (bCDsu-ss-Ce6). Chemical composition of bCDsu-ss-Ce6 was confirmed with 1H and 13C NMR spectra. bCDsu-ss-Ce6 nanophotosensitizers were fabricated by dialysis procedure. They formed small particles with an average particle size of 152.0±23.2 nm and they showed improved singlet oxygen (SO) generation in the aqueous solution under light irradiation and was significantly higher than that of Ce6 alone. Ce6 release rate from bCDsu-ss-Ce6 nanophotosensitizers was accelerated by addition of glutathione (GSH), indicating that bCDsu-ss-Ce6 nanophotosensitizers have re-dox-sensitive photosensitizer delivery capacity. bCDsu-ss-Ce6 nanophotosensitizers have low in-trinsic cytotoxicity against CCD986Sk human skin fibroblast cells as well as Ce6 alone. However, bCDsu-ss-Ce6 nanophotosensitizers showed improved Ce6 uptake ratio, higher reactive oxygen species (ROS) production and phototoxicity compared to those of Ce6 alone. GSH addition resulted in higher Ce6 uptake ratio, ROS generation and phototoxicity than those of Ce6 alone, indicating that bCDsu-ss-Ce6 nanophotosensitizers have redox-sensitive biological activity in vitro against HeLa human cervical cancer cells. At tumor xenograft model using HeLa cells, bCDsu-ss-Ce6 nanophotosensitizers efficiently accumulated in the tumor rather than normal organs, i.e. fluores-cence intensity in tumor tissues was significantly higher than those of other organs while Ce6 alone did not specifically target tumor tissue. These results indicated higher anticancer activity of bCDsu-ss-Ce6 nanophotosensitizers, by efficiently inhibiting growth of tumor in in vivo animal tumor xenograft study.

Preprint REVIEW | doi:10.20944/preprints202109.0449.v1

Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?

Lena Palaniyappan, Min Tae M. Park, Peter Jeon, Roberto Limongi, Kun Yang, Akira Sawa, Jean Théberge

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: glutathione; glutamate; psychosis; schizophrenia; redox; antioxidant; oxidative stress; myelin; spectroscopy

Online: 27 September 2021 (12:47:39 CEST)

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Working Paper ARTICLE

Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome

Jason M. Held

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cysteine oxidation redox systems biology proteomics signaling EGFR cryptic

Online: 10 April 2019 (10:07:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1382.v2

Acoustic Characterization of Potential Quiet Areas in Dortmund, Germany

Bryce T. Lawrence, Andreas Frücht, Damian Heying, Kai Schröer, Dietwald Gruehn

Subject: Social Sciences, Geography, Planning And Development Keywords: Noise Action Plan; Noise Mapping; Quiet Areas; Biophony Mapping; Diel Patterns; Noise Hot Spot; Multiple Decision Criteria Assessment; Linear Combination Suitability Mapping

Online: 11 March 2024 (13:17:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0222.v1

Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients

Ewa Ambrożewic, Piotr Wojcik, Adam Wronski, Wojciech Luczaj, Anna Jastrząb, Neven Zarkovic, Elżbieta Skrzydlewska

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: psoriasis, arthritis, inflammation, granulocytes, redox signaling, oxidative stress, lipid peroxidation, 4-hydroxynonenal, lipids, endocannabinoid system

Online: 12 September 2018 (13:43:16 CEST)

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Inflammatory granulocytes are characterized by oxidative burst, which may promote oxidative stress and lipid modification both in affected tissues and on systemic level. On the other hand, redox signaling involving lipid peroxidation products acting as second messengers of free radicals play important, not yet fully understood, roles in pathophysiology of inflammation and various stress-associated disorders. Therefore, the aim of this study was to evaluate the onset of oxidative stress and alterations of enzyme-dependent lipid metabolism resulting from redox imbalance in granulocytes and plasma obtained from patients with psoriasis vulgaris or psoriatic arthritis, in comparison to the healthy subjects. The results obtained revealed enhanced activity of pro-oxidant enzymes NADPH and xanthine oxidases in granulocytes, with a decrease of enzymatic and non-enzymatic antioxidants in plasma of psoriatic patients. The Nrf2 and its regulators were increased in both forms of psoriasis, while HO-1 levels were increased only in psoriasis vulgaris. Redox imbalance was associated with decreased levels of phospholipids and of free PUFAs, but with enhanced activity of enzymes involved in lipid metabolism (PLA2, PAF-AH COX1/2) and increased lipid peroxidation products 4-hydroxynonenal (4-HNE), isoprostanes and neuroprostanes. Increased endocannabinoids and GPR55 were observed in both forms of the disease, while expression of CB1 was increased only in pateints with psoriatic arthritis, opposite to CB2, which was increased only in psoriasis vulgaris. Protein modifications by ROS and lipid peroxidation product 4-HNE promoted apoptosis of granulocytes by increased caspases in both forms of psoriasis. This study indicates that excessive activation of granulocytes, causing oxidative stress and lipid modifications, is an important pathophysiology of psoriasis. Consequently, lower Nrf2 activity and CB2 expression may promote progression of psoriasis into advanced, arthritic form of the disease.

Preprint ARTICLE | doi:10.20944/preprints202409.2187.v1

High-Performance Dual-Redox-Mediator Supercapacitors Based on Buckypaper Electrodes and Hydrogel Polymer Electrolytes

Garbas A. Santos Junior, Kélrie H. A. Mendes, Sarah G. G. de Oliveira, Gabriel J. P. Tonon, Neide P. G. Lopes, Thiago H.R. da Cunha, Mario Guimarães Junior, Rodrigo L. Lavall, Paulo F. R. Ortega

Subject: Electrochemistry, Chemistry And Materials Science Keywords: buckypaper; supercapacitor; carbon nanotubes; hydrogel polymer electrolyte; redox-mediator

Online: 27 September 2024 (07:54:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0137.v1

Effect of 5-Azacitine Treatment on Redox Status and Inflammatory Condition in MDS Patients

Paola Montes, Ana Guerra-Librero, Paloma García, Mª Elena Cornejo-Calvo, Mª del Señor López, Tomás de Haro, Laura Martínez-Ruiz, Germaine Escames, Darío Acuña-Castroviejo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: myelodysplastic syndrome (MDS); oxidative stress; cytokines; inflammation; 5-Azacitidine; somatic alterations

Online: 8 December 2021 (14:36:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0203.v1

Molecular Cloning and Expression Analysis of COX II from Sitophilus zeamais, a Potential Action Site of AITC

Changliang Hou, Jingbo Wang, Hua Wu, Jiayu Liu, Zhiqing Ma, Juntao Feng, Xing Zhang

Subject: Biology And Life Sciences, Insect Science Keywords: Sitophilus zeamais; COXⅡ; Soluble proteins; Enzyme activity; AITC

Online: 25 August 2016 (10:11:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0932.v1

Cheiloscopic Evaluation in Forensic Odontostomatology: Exploring Potential and Limitations

Emanuele Di Vita, Davide Albano, Andrea Trizzino, Fabio Massimo Sciarra, Simone Vintrici, Lorenzo Reali, Enzo Cumbo, Giuseppa Bilello, Stefania Zerbo, Antonella Argo, Pietro Messina, Giuseppe Alessandro Scardina

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Cheiloscopy; Forensic dentistry; Lip prints; Sex.

Online: 13 June 2024 (14:55:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0031.v1

Direct Electron Transfer-type Bioelectrocatalysis of Redox Enzymes at Nanostructured Electrodes

Taiki Adachi, Yuki Kitazumi, Osamu Shirai, Kenji Kano

Subject: Chemistry And Materials Science, Electrochemistry Keywords: direct-electron transfer-type bioelectrocatalysis; nanostructures; mesoporous electrodes, curvature effect; protein engineering; bi-directional bioelectrocatalysis; hydrogenase; fructose dehydrogenase; bilirubin oxidase; formate dehydrogenase; ferredoxin-NADP+ reductase

Online: 3 February 2020 (13:34:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.2506.v1

Metabolic function and Therapeutic Potential of CD147 for Hematological Malignancies: An Overview

Isabella Spinello, Catherine Labbaye, Ernestina Saulle

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Hematological Malignancies; Metabolism; CD147

Online: 31 July 2024 (11:07:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1717.v1

Formulation and Characterization of DES and Potential Application in Recycling Packaging Laminates

Adamantini Loukodimou, Christopher Lovell, Tianmiao Li, George Theodosopoulos, Kranthi Kumar Maniam, Shiladitya Paul

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: DES; laminate packaging materials; blister packs; recycle; carboxylic acids; delamination

Online: 23 August 2024 (10:31:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1936.v1

Microbial Consortium of Jeju Traditional Fermented Foods and Their Cosmetic Ingredient Potential

Sung-Eun Bae, Sungmin Bae, Sung Jin Park, Pomjoo Lee, Chang-Gu Hyun

Subject: Biology And Life Sciences, Food Science And Technology Keywords: B16F10 melanoma; Jeju traditional fermented foods; macrophage; melanin; nitric oxide; skin irritation

Online: 29 May 2024 (07:51:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.0976.v1

The Potential Influence of Residual or Recurrent Disease on Bevacizumab Treatment Efficacy in Ovarian Cancer

Klaudia Żak, Małgorzata Satora, Ilona Skrabalak, Rafał Tarkowski, Marta Ostrowska-Leśko, Marcin Bobiński

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bevacizumab; ovarian cancer; angiogenesis; VEGF

Online: 19 February 2024 (11:19:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1455.v1

GIPR Overexpression Reduces the Tumorigenic Potential of Retinoblastoma Cells

André Haase, Emily Alefeld, Fatma Yalinci, Dario Van Meenen, Maike Anna Busch, Nicole Dünker

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: retinoblastoma; RB; gastric inhibitory polypeptide receptor; GIPR; trefoil factor family peptide; TFF1; CAM; tumorigenesis; MK0893; miR5-542-5p

Online: 25 March 2024 (08:36:23 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202402.1404.v1

Exploring the Potential Use of Natural Products Together with Alkalization in Cancer Therapy

Masahide Isowa, Reo Hamaguchi, Ryoko Narui, Hiromasa Morikawa, Toshihiro Okamoto, And Hiromi Wada

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: tumor microenvironment; alkalization therapy; natural products; cancer, complementary and alternative medicine

Online: 26 February 2024 (09:30:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1398.v1

Sensory Properties, Redox Characteristics, and Impact on the Hemodynamics of the Flavanol-Rich Fraction Originated Grape and Blueberry

Naomi Osakabe, Toshihiko Shoji, Kurumi Onishi, Chie Hirahata, Kento Hiroki, Taiki Fushimi, Yasuyuki Fujii, Ursula Jacob, Ali Abdelhameed, Rosanna Di Paola, Salvatore Cuzzocrea, Vittorio Calabrese

Subject: Medicine And Pharmacology, Other Keywords: flavanol; astringency; O2･-; blood flow; sympathetic nerve

Online: 23 March 2024 (09:38:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.1016.v1

Nutraceuticals Modulating Mitophagy May Combat the Mitochondrial Dysfunction and Redox Stress in Several Cardiac Disorders

Moeka Nakashima, Naoko Suga, Satoru Matsuda

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: autophagy; mitophagy; AMPK; cardiomyocyte; cardiac arrhythmia; cardiovascular disease; cardiac failure

Online: 16 April 2024 (16:27:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0662.v1

New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics

Yingyu Pan, Jianing Li, Zhengyang Fan, Yonghao Chen, Xiaoxuan Huang, Dong Wu

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic pancreatitis; probiotics; prebiotics; gut microbiota

Online: 12 August 2024 (03:05:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0119.v1

The Potential Threats of Spodoptera frugiperda (Lepidoptera: Noctuidae) on Tropical Economic Tree Species

Jiabao Xue, Yi Chen, Xiangyi Kong, Ruizong Jia, Xiaoqi Jiang, Jingyuan Guo, Yunling Guo, Yan Yang

Subject: Biology And Life Sciences, Forestry Keywords: Spodoptera frugiperda; woody plants; economic tree species; host plants; adaptation

Online: 4 March 2024 (10:24:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0005.v1

Molecular Testing Based Assessment of the Potential Aggressiveness of Papillary Thyroid Carcinoma

Sergei A. Lukyanov, Sergei E. Titov, Evgeniya S. Kozorezova, Pavel S. Demenkov, Yulia A. Veryaskina, Denis V. Korotovskii, Tatyana E. Ilyina, Sergey L. Vorobyev, Vladimir A. Zhivotov, Nikita S. Bondarev, Ilya V. Sleptsov, Sergei V. Sergiyko

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: papillary thyroid carcinoma; aggressive variants; recurrence risk; miRNA-221; miRNA-146b; FN1; CDKN2A

Online: 3 June 2024 (11:52:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0356.v1

Redox Regulation of PTEN by Reactive Oxygen Species: Role in Physiological Processes

Vu Hoang Trinh, Thang Huu Nguyen, Dhiraj Kumar Sah, Jin Myung Choi, Hyun Joong Yoon, Sang Chul Park, Yu Seok Jung, Seung-Rock Lee

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: PTEN; redox regulation; oxidative inhibition; ROS; cell signaling

Online: 5 January 2024 (02:00:24 CET)

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Preprint REVIEW | doi:10.20944/preprints201909.0244.v1

Cofactor F₄₂₀-Dependent Enzymes: An Under-Explored Resource for Asymmetric Redox Biocatalysis

Mihir V. Shah, James Antoney, Suk Woo Kang, Andrew C. Warden, Carol J. Hartley, Hadi Nazem-Bokaee, Colin J. Jackson, Colin Scott

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: cofactor F420; deazaflavin; oxidoreductase; hydride transfer; hydrogenation; asymmetric synthesis; cofactor biosynthesis

Online: 21 September 2019 (01:28:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0684.v1

Potential and Limits of the Synergy Between Cheiloscopy and Rugoscopy in Forensic Odontology

Andrea Trizzino, Davide Albano, Emanuele di vita, Fabio M Sciarra, Simone Vintrici, Lorenzo Reali, Enzo Cumbo, Giuseppa Bilello, Stefania Zerbo, Antonella Argo, Pietro Messina, Giuseppe Alessandro Scardina

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Cheiloscopy; Rugoscopy, Forensic dentistry; Sex

Online: 11 June 2024 (05:50:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0558.v1

Long COVID: G Protein-Coupled Receptors (GPCRs) Associated Genes and Pathways as a Promising Therapeutic Potential Through Computational Analysis

Dhanyashri Guruparan, Suresh Kumar

Subject: Biology And Life Sciences, Virology Keywords: long COVID; GPCR signaling pathways; therapeutic targets; drug repurposing; bioinformatics

Online: 8 August 2024 (12:18:41 CEST)

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Long COVID, also referred to as post-COVID-19 condition, describes the lingering after-effects of COVID-19 infection. This complex syndrome encompasses a range of symptoms affecting physical well-being, cognitive function, and mental health. The widespread impact of long COVID extends beyond individual sufferers, placing significant strain on healthcare systems and causing far-reaching socioeconomic consequences. The scale of this multifaceted health crisis is unparalleled in recent history, affecting millions globally and challenging our understanding of post-viral conditions. This study aimed to explore the possibility of targeting G protein-coupled receptors (GPCRs) signaling pathway-related genes as therapeutics for long COVID using computational analysis. Targeting GPCRs and their signaling pathways holds significant promise for long COVID therapeutics, as these receptors are involved in crucial physiological processes including immune regulation, inflammation control, and neurotransmission. All of these are implicated in the diverse and persistent symptoms of long COVID, potentially offering a versatile approach to addressing multiple aspects of the condition simultaneously. This study identified 21 genes associated with GPCRs for further exploration as potential targets. Notably, GPCR genes such as HRAS, KRAS, GNAQ, and GNA11 were determined to be possible therapeutic targets for the pathophysiological mechanisms of long COVID. FDA-approved drugs targeting these genes were identified, including Binimetinib, Cabozantinib, Selumetinib, Panitumumab, Cetuximab, Adagrasib, Tipifarnib, and Sotorasib. Additionally, Naltrexone and Tipifarnib have emerged as potential new treatment options for long COVID. SARS-CoV-2 may hijack GPCR signaling pathways to dysregulate lung ion and fluid transport, contributing to the pathophysiology of pulmonary edema in patients with COVID-19. Further research is required to translate the findings into the development of therapeutics and to investigate the relationship between viral infection and GPCR signalling.

Preprint REVIEW | doi:10.20944/preprints202407.1742.v1

Exploring the Potential Influence of Human Gut Microbiota on Gut Resistome: A Systematic Review

Justine Fri, Mulalo Raphalalani, Lufuno Grace Mavhandu-Ramarumo, Pascal Obong Bessong

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Gut microbiota; Gut resistome; Antibiotic resistance genes; Escherichia coli

Online: 23 July 2024 (07:25:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0152.v1

Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Alzheimer’s disease; oxidative stress; presenilin; mitochondria; calcium; neuronal dysfunction; Nrf2

Online: 11 July 2022 (08:03:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0357.v1

Transcriptomics Reveals Granulosa Cell’s Coping through Redox, Inflammatory, Metabolic and Cytoskeleton Mechanisms under Acute Heat Stress

Abdul Sammad, Hanpeng Luo, Lirong Hu, Huabin Zhu, Yachun Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: granulosa cells; heat stress; apoptosis; oxidative stress; RNA-seq; transcriptomics; differentially expressed genes; signaling pathways

Online: 28 February 2022 (11:08:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.2173.v1

Circulating Extracellular Mitochondria in Cardiometabolic Disease: Harnessing the Potential for Diagnosis, Prognosis, and Treatment

Michail Spanos, Priyanka Gokulnath, Olivia Rosina Whittaker, Christopher Azzam, Emeli Chatterjee, Aarush Singh, Dimitrios Varrias, Michail Kladas, Guoping Li, Gururaja Vulugundam, Saumya Das

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Circulating Extracellular Mitochondria; Cardiometabolic Disease; Diabetes; Obesity

Online: 3 June 2024 (08:10:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints201702.0020.v1

Potential Modes of Intercellular Alpha-Synuclein Transmission

Dario Valdinocci, Rowan A. W. Radford, Sue Maye Siow, Roger S. Chung, Dean L. Pountney

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: alpha-synuclein; Parkinsons disease; dementia with Lewy bodies; multiple system atrophy; tunelling nanotube; glymphatic system; cell-to-cell spread

Online: 7 February 2017 (03:24:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0742.v2

On How to Measure the Subdivision Potential in Nanothermodynamics

Dick Bedeaux, Signe Kjelstrup

Subject: Physical Sciences, Thermodynamics Keywords: Nanothermodynamics; Subdivision potential; Porous media; Shape dependence; Scaling laws

Online: 6 March 2024 (04:15:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0883.v1

New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cholinergic; HI-6; nerve agents; reactivators; Vilsmeier; Wittig reaction

Online: 13 May 2024 (14:38:38 CEST)

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New furan, thiophene and triazole oximes were synthesized through several-step reaction paths to investigate their potential for development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus compound (OP) poisonings. Acute OP poisoning is still a challenge in treating patients despite the development of a large number of oxime compounds that should have the capacity to reactivate acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The activity of these two enzymes, crucial for neurotransmission, are blocked by the OP, which has the consequence of disturbing normal cholinergic nerve signal transduction in the peripheral and CNS, leading to cholinergic crisis. Oximes in use have one or two pyridinium rings and cross the brain–blood barrier poorly due to the quaternary nitrogen. Following our recent study on 2-thienostilbene oximes, in this paper we described the synthesis of 63 heterostilbene derivatives out of which 26 oximes were tested as inhibitors and reactivators of AChE and BChE inhibited by OP nerve agents – sarin and cyclosarin. While the majority of oximes were potent inhibitors of both enzymes in micromolar range, we identified several oximes as BChE or AChE selective inhibitors with a potential for drug development. Moreover, even oximes were poor reactivators of AChE, four heterocyclic derivatives reactivated the cyclosarin-inhibited BChE up to 70%, and cis,trans-5 [2-((Z)-2-(5-((E)-(hydroxyimino)methyl)thiophen-2-yl)vinyl)benzonitrile] had comparable reactivation efficacy to the standard oxime HI-6. In silico analysis and molecular docking studies connected the kinetic data to the structural features of these oximes, and confirmed their productive interactions with the active site of the cyclosarin-inhibited BChE. Based on inhibition and reactivation and their ADMET properties regarding lipophilicity, CNS activity, and hepatotoxicity, these compounds could be considered for further development of CNS-active reactivators in OP poisoning as well as cholinesterase-targeted therapeutics in neurodegenerative diseases like Alzheimer’s and Parkinson’s.

Preprint REVIEW | doi:10.20944/preprints202403.0592.v1

Exploring the Anti-inflammatory Potential of Mangrove Flora: A Comprehensive Review

Shahinur Rahman

Subject: Biology And Life Sciences, Plant Sciences Keywords: Bioactive compounds; Mechanisms of Inflammation; Traditional treatment; Chemical structure; Mangrove plants; Anti-inflammatory activity

Online: 14 March 2024 (05:30:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0382.v1

Bicarbazole-benzophenone based twisted donor-acceptor derivatives as potential blue emitters for OLEDs

Iram Siddiqui, Prakalp Gautam, Dovydas Blazevicius, Jayakumar Jayakumar, Sushanta Lenka, Daiva Tavgeniene, Ernestas Zaleckas, Jwo-Huei Jou, Saulius Grigalevicius

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: donor-acceptor derivatives; blue organic light emitting diode; high efficiency; blue emission; thermal analysis

Online: 7 March 2024 (09:34:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1369.v1

Placental Protein 13 (PP13): Vasomodulatory Effects on Human Uterine Arteries and Potential Implications for Preeclampsia

Mariacarmela Gatto, Milena Esposito, Michele Morelli, Silvia De Rose, Sveinbjorn Gizurarson, Hamutal Meiri, Maurizio Mandalà

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Galectin; Nitric-oxide; cGMP; vascular tone; Gestational hypertension

Online: 20 June 2024 (00:11:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1223.v1

Serum Markers for Evaluating Beef Meat Quality: Potential Applications in Cell-Cultured Meat Production

Chandrasekhar Kathera, Jihoe Kim

Subject: Biology And Life Sciences, Food Science And Technology Keywords: cell-culture meat; beef meat evaluation; serum biomarkers; cell culture media

Online: 20 March 2024 (12:23:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1454.v1

Assessment of the potential for sustainable sugarcane production for bioenergy in Angola

Adilson João Matias, Luiz Augusto Horta Nogueira, Eric Alberto Ocampo Batlle

Subject: Engineering, Energy And Fuel Technology Keywords: Angola; Sugarcane; Sustainable land use

Online: 20 June 2024 (15:05:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1789.v1

Assessment of the Potential Contribution of the Urban Green System to the Carbon Balance of Cities

Maria Elena Menconi, Livia Bonciarelli, David Grohamnn

Subject: Biology And Life Sciences, Forestry Keywords: urban park; carbon balance; carbon sequestration; urban trees maintenance; scenario analysis; i-Tree Eco; tree cadastre; tree inventory; proximity services; ecosystem services

Online: 29 March 2024 (07:24:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0825.v1

Identifying Potential Therapeutic Targets in Long COVID Related Inflammatory, Coagulation, Mitochondrial, and Oxidative Stress Pathways through In Silico Approach

Suresh Kumar, Philemon Telajan Anak Sigai

Subject: Biology And Life Sciences, Virology Keywords: long COVID; SARS-CoV-2; inflammatory; coagulation; mitochondria; drug target; durgs

Online: 12 August 2024 (13:32:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.2069.v1

The Redox Homeostasis Alteration Is Restored by Melatonin Treatment in COVID-19 Patients

María Elena Soto, Israel Pérez-Torres, Linaloe Manzano-Pech, Adrían Palaciós-Chavarría, Rafael Ricardo Valdez-Vázquez, Verónica Guarner-Lans, Elizabeth Soria-Castro, Eulises Díaz-Díaz, Vicente Castrejón-Tellez

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Melatonin; SARS-CoV-2; oxidative stress; COVID-19; redox homeostasis; antioxidant enzymes

Online: 31 January 2024 (01:47:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0048.v1

In-Situ Flexibility of Both Redox-States of the Chloroplast Regulatory Protein CP12

Helene Launay, Hui Shao, Olivier Bornet, Francois-Xavier Cantrelle, Regine Lebrun, Veronique Receveur-Brechot, Brigitte Gontero

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Calvin-Benson-Bassham cycle; Conditionally disordered protein; Intrinsically disordered protein; photosynthesis regulation.

Online: 2 April 2021 (11:23:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0899.v1

Exploring the Therapeutic Potential of N-Methyl-D-Aspartate Receptor Antagonists in Neuropathic Pain Management

Ciprian Pușcașu, Cornel Chiriță, Simona Negreș, Nicoleta Mirela Blebea

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: neuropathic pain; NMDA receptor antagonist; ketamine; memantine; methadone

Online: 11 September 2024 (15:02:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1005.v1

Study on the Projection of Potential Evapotranspiration Trend in Yangtze River Delta and the Uncertainty

Lu Ding, Yi Yu, Shaobo Zhang

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: potential evapotranspiration; temperature; projection; uncertainty; robustness

Online: 19 February 2024 (07:55:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1896.v1

The Rise of Proterozoic Diagenetic Spheroids Formed by Chemically Oscillating Reactions and Stimulated by Environmental Redox Changes

Princess Aira Buma-At, Dominic Papineau

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: concretion; botryoid; diagenesis; carbon cycle; fossilisation; Belousov-Zhabotinsky

Online: 27 August 2024 (11:10:31 CEST)

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Diagenetic spheroids are rounded mineralised structures in sedimentary rocks that span several orders of size dimensions. These objects include rosettes spanning tens of micrometres, millimetre-sized granules, and centimetre- to metre-scale botryoids, nodules and concretions. Connections between diagenetic spheroids and chemically oscillating reactions (COR) have been established based on chemical and pattern similarities. Nevertheless, it is unknown if there are variations in their occurrences throughout geological time, especially during periods of global environmental change. This is because COR are pattern-forming reactions where carboxylic acids are decarboxylated by strong oxidants like sulphuric acid, bromate, or iodate. The hypothesis is that there should be a greater number of diagenetic spheroids at periods of increased atmospheric-oceanic oxygenation levels. Hence, this work presents the first compilation of occurrences of diagenetic spheroids between 0.541 to 1.8 billion years ago (Ga). The compiled patterned objects are those with concentric laminations and radially aligned crystals, which are patterns akin to equidistant circularly concentric waves that radially propagate in COR. Another characteristic of diagenetic spheroids, such as in botryoidal minerals, is the destructive interfere that forms circular twins; this is identical to the COR pattern formed when circular waves meet. The timeline of Proterozoic diagenetic spheroids produced in this work reveals a significant increase of occurrences across the Ediacaran, which is attributed to increased environmental oxidation state. During this interval, seawater is known to have become richer in sulphate and iodate, which create ideal conditions for the abiotic and diagenetic oxidation of biomass. Therefore, increased occurrences of diagenetic spheroids in the Neoproterozoic possibly represents sedimentological evidence for abiotic decarboxylation reactions and widespread COR in productive environments. The distribution of diagenetic spheroids observed during the Proterozoic may also be more broadly applicable to other epochs of Earth history.

Preprint REVIEW | doi:10.20944/preprints202205.0294.v2

The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways. Crosstalk on Perioperative Antioxidant Therapy

Stelian Adrian Ritiu, Alexandru Florin Rogobete, Dorel Sandesc, Ovidiu Horea Bedreag, Marius Papurica, Sonia Elena Popovici, Daiana Toma, Robert Iulian Ivascu, Raluca Ramona Velovan, Dragos Nicolae Garofil, Dan Corneci, Melania Lavinia Bratu, Elena Mihaela Pahontu, Adriana Pistol

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: general anesthesia; redox; inflammation; antioxidants; hypermetabolism; microRNAs; biomarkers; oxidative stress; Vitamin C

Online: 6 June 2022 (05:09:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0201.v1

Market Potential of Applying Autonomous Vehicles in the Shared Mobility Market: Opportunities and Challenges

Lin Tu, Min Xu

Subject: Social Sciences, Transportation Keywords: autonomous vehicle; shared mobility; SWOT analysis; PESTLE analysis; Porter’s Five Forces

Online: 2 July 2024 (10:36:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0143.v1

Development of Potential Slip Surface Identification Model for Active Deep-seated Landslide Sites: A Case Study in Taiwan

Shih-Meng Hsu, Chun-Chia Hsiung, Yu-Jia Chiu, Yi-Fan Liao, Jie-Ru Lin

Subject: Engineering, Civil Engineering Keywords: disturbed rock formation; landslide slip surface; hydraulic conductivity; principle component analysis; geological indicators

Online: 3 September 2024 (11:35:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0030.v1

Synthesis and Characterization of Ethylenedithio-MPTTF-PTM Radical Dyad as a Potential Neutral Radical Conductor

Manuel Souto, Dan Bendixen, Morten Jensen, Jan O. Jeppesen, Imma Ratera, Concepció Rovira, Jaume Veciana

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: neutral organic radical; perchlorotriphenylmethyl radical; tetrathiafulvalene; donor-acceptor

Online: 4 November 2016 (14:19:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1121.v1

Invasive Buttonweed Cotula coronopifolia (Asteraceae) Is Halotolerant and Has High Potential for Dispersal by Endozoochory

Raúl Sánchez-García, Andy J. Green, Lina Tomasson, Francisco Hortas, Maria A. Ortiz

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: endozoochory; dry-fruited seeds; dispersal syndromes; salinity; gut passage; non-indigenous species

Online: 17 May 2024 (08:01:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0909.v1

Exploring the Immunomodulatory Potential of Pancreatic Cancer-Derived Extracellular Vesicles through Proteomic and Functional Analyses

Anna Piro, Maria Concetta Cufaro, Paola Lanuti, Davide Brocco, Laura De Lellis, Rosalba Florio, Serena Pilato, Sara Pagotto, Simone De Fabritiis, Simone Vespa, Giulia Catitti, Fabio Verginelli, Pasquale Simeone, Damiana Pieragostino, Piero Del Boccio, Antonella Fontana, Antonino Grassadonia, Alessandro Cama, Serena Veschi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pancreatic cancer; extracellular vesicles; immune response

Online: 15 April 2024 (07:21:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0365.v1

The Role of Natural Factors that Optimize Redox Status in Combating Type 2 Diabetes

Dawn S. Tuell, Evan A. Los, George A. Ford, William L. Stone

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: antioxidants; oxidative stress; reactive oxygen species; type 2 diabetes; pediatrics; redox; glycemic control; exercise; vitamin E; glutathione

Online: 19 January 2023 (15:10:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0902.v1

Potential Impacts of Diversification of Food Retail Working Hours on Consumer Behaviour and the Benefits for Local Producers

Liga Proskina, Lana Janmere, Sallija Cerina, Irina Pilvere, Aija Pilvere, Aleksejs Nipers, Daniela Proskina

Subject: Business, Economics And Management, Economics Keywords: agri-food; consumer behavior, food retail; Sunday trade regulation; local food trade

Online: 11 September 2024 (16:20:01 CEST)

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The capability of large food retail chains to respond quickly to changes in consumer behaviour and their dominant market position affects all food market players and often conflicts with the interests of national food producers, which can reduce the presence of locally sourced products in the food product mix in the country. In Latvia, there have been several proposals to limit retailers' opening hours on weekends and public holidays to increase the viability of small local food producers, retailers, and catering enterprises; however, limiting retailers' opening hours without research-based arguments is unacceptable. The research studies conducted in Europe also do not give a unified conclusion. Household consumer behaviour in the food market is viewed as an essential argument for increasing domestic demand and economic stability. Accordingly, the present research aims to identify the impacts of diversification of opening hours of food supermarkets on consumer shopping habits and the implications for creating an advantage for small and medium agri-food producers in selling their products. The research applied a quantitative approach to identify the main trends in society (n=2738), with a survey including 31 variables to quantify consumer behaviour, values, and opinions and seven socio-demographic variables. If a decision were made in Latvia to close grocery shops on Sundays or reduce their opening hours on weekends, 85% of consumers indicated that they would be unlikely to change their usual shopping location and would plan to shop at a supermarket on other days. The choice between farmers' markets and local food shops on Sundays would be made by 45% of consumers, with more than half (53%) of them shopping at local food shops at least a few times a month. It could, therefore, be argued that reducing the opening hours of supermarkets and closing them on Sundays and public holidays do not provide a competitive advantage and do not divert consumers to small and medium agri-food producers.

Preprint REVIEW | doi:10.20944/preprints202409.1650.v1

Nano-Engineering Halide Perovskites: Towards Energy Harvesting, Nano-Plasmon Sensing and Photoflexoelectric Potential Applications

Taame Abraha Berhe, Wei-Nien Su, Bing Joe Hwang

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: nano-engineering; microscopic origin; strain; energy harvesting; photo-sensing; Nano-plasmonic sensing; photoflexoelectricity; halide perovskites

Online: 23 September 2024 (08:09:02 CEST)

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Halide perovskite are known by their (1) organic inorganic hybrid and (2) inorganic halide perovskite. Having this in mind, monolithic perovskite/silicon tandem solar cell has already demonstrated extraordinarily high performance in the field of photovoltaic with current efficiency of 29.15%, breaking the efficiency limit for silicon solar cell. Currently, halide perovskites become successful not only in photovoltaic but also in many other related potential optoelectronic applications. Because of this reason, the origin of their multifunctional properties, remarkable energy harvesting and emitting efficiency and the corresponding potential applications in various optoelectronic devices become controversial issues and hot topics of academic research this time. In this review, nano-engineering strategies, microscopic origins and mechanisms are reviewed well to make clarity on what the origin of multifunctional properties such as tunability, ferroelasticity, piezoelectricity, pyroelectricity and thermoelectric properties of halide perovskites. Moreover, the coexistence of multiple properties makes halide provskites possible for synergistic applications and multifunctional perspectives such as emerging energy harvesting, conversion technologies, nano-plasmonic sensing and electromechanical applications, which are now open for the scientific community for further detail investigations. To successfully explore this field, advanced nanometer scale domain characterization tools are highly relevant to understand the microscopic origin of these electrical properties; aid the commercial enterprises and the research institutions. Not only the microscopic origin but also identifying factors and issues affecting the successful understanding and presence or absence of these electrical parameters should be primary task in this review. Finally, the big challenges for operation of halide perovskites owing to temperature, moisture, light, air, etc. induced material degradation and device deteriorations as well as lattice instability, nano scale defects, surface and bulk defects should be considered while dealing with these future research topics.

Preprint ARTICLE | doi:10.20944/preprints202409.1030.v1

Unveiling the Nutrient Signatures in Corn (Zea Mays L.) Grains: A Pivotal Indicator of Yield Potential

Nour Ismail, Lotfi Khiari, and Rachid Daoud

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Nutrient Diagnosis Norms (NDN); Nutrient signature; Global nutrient imbalance index (GNII); High yielding subpopulation

Online: 12 September 2024 (15:41:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0087.v1

Current Treatment Approaches to Eliminate Borrelia burgdorferi and Potential Strategies to Alleviate Persistent Lyme Disease Symptoms

Kashaf Zafar, Onyedikachi Azuama, Nikhat Parveen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Lyme disease; Borrelia burgdorferi; Treatment; antimicrobials; Post-treatment Lyme disease syndrome; PTLDS

Online: 2 May 2024 (12:03:42 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202406.0407.v1

Enhanced Cortical Plasticity in Alzheimer’s Disease: Exploring ccPAS Potential.

Chiara Di Fazio, Marco Tamietto, Mario Stanziano, Anna Nigri, Sara Palermo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's disease; cortico-cortical spike timing-dependent plasticity; ccPAS; motor performance; brain plasticity; neuronavigation; rehabilitation; brain aging

Online: 10 June 2024 (12:28:37 CEST)

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