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Preprint ARTICLE | doi:10.20944/preprints202406.1497.v1

Short- and Long-Term Neurobehavioral Effects of the Developmental Exposure to Valproic Acid in Zebrafish

Marina Ricarte, Niki Tagkalidou, Marina Bellot, Juliette Bedrossiantz, Eva Prats, Cristian Gomez-Canela, Natalia Garcia-Reyero, Demetrio Raldúa

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: valproic acid; animal model; zebrafish; autism spectrum disorder; social behavior; neurotransmitter

Online: 21 June 2024 (10:45:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0150.v1

Bloodmeal, and Selected Indigenous Raw Materials as Cost-Effective Feeds for Milkfish Aquaculture

Edison D. Macusi, John Edward M. Jimenez, Ethel Kate E. Vender, Henzel P. Bong-as, Erna S. Macusi, Michael B. Andam

Subject: Biology And Life Sciences, Aquatic Science Keywords: Banana stem; bloodmeal; circular economy; milkfish (Chanos chanos); taro (Colocasia esculenta)

Online: 3 September 2024 (10:32:25 CEST)

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This study is based on the clamor of fish farmers for a cheaper fish feed alternative to current commercial feeds. At present, 70-80% of aquaculture costs come from feed cost, keeping farmers' income below their expectation. This study aimed to find alternative feeds or supplementary feeds that can perform similarly to the existing commercial feeds thereby reducing farmer expense and cutting down their cost of production and increasing their profitability. To do that, various indigenous raw materials were selected based on an earlier study which could result in a better feed alternative. The formulations for the study included four grow-out treatments mainly: control (commercial feed), taro+control (powdered Colocasia esculenta+commercial fish feed), bloodmeal (formulated fish feed based on bloodmeal), banana stem+control (chopped banana stem+commercial fish feed). A total of 12,000 fingerlings initially weighing 16 g (TL=10 cm) individually were assigned randomly to the four treatments (3000 in each cage measuring 6 x 6 m). Week zero was used for acclimation period, and fingerlings were fed with commercial fish feed. Then the first week used the treatment diets which were adjusted based on average body weight and sampled weekly (ABW=23g; TL=11 cm). The result of the study first showed significant differences between treatments on their fourth week in terms of the diet treatments (MS=0.103, df=3, F=4.12, P=0.0076) with the control and the taro+control showing no difference in terms of weight and length (TC vs CF; P=0.4524). But during the fifth week, the bloodmeal treatment showed increased weight and length for fish sampled (MS=0.109, df=3, F=4.10, P=0.0076) and provided similar weight and length as those from the taro+control and the control (TC vs CF; P=0.3721 and BM vs CF; P=0.0587). During the succeeding weeks, there were no significant differences between feed treatments from 6th weeks onwards, whether with weight [MS=0.130, df=3, F=1.14, P=0.333] or total length of the treatments [MS=0.008, df=3, F=0.40, P=0.75]. The FCR ratio showed taro (1.81) as lowest, followed by blood meal (2.09), and control (2.24) and then banana stem (2.84). In terms of weight gain, fish from the bloodmeal treatment gained the highest (236.97 g), followed by control (223.33 g), then taro (217.67 g) and banana stem (196.99 g). As a result, we find that the tested treatments such as bloodmeal formulated feed, taro+commercial feed, and banana stem+commercial feed can serve as an alternative to purely commercial fish feeds. Cost-benefit analysis showed that a better gross profit margin of 42% and cost-benefit ratio of 1.37 was observed in taro+commercial feed diet.

Preprint ARTICLE | doi:10.20944/preprints202403.0148.v1

Analyzing the Effect of Age, Time of the Day and the Experiment on the Basal Locomotor Activity and Light-Off Visual Motor Response Assays in Zebrafish Larvae

Niki Tagkalidou, Cristiana Roberta Multisanti, Maria Jose Bleda, Juliette Bedrossiantz, Eva Prats, Caterina Faggio, Carlos Barata, Demetrio Raldúa

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: zebrafish larvae; behavioral analysis; intrinsic factors; age; time of day; experiment; basal locomotor activity; visual motor response

Online: 5 March 2024 (05:06:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.1403.v2

Reconciling Environmental Safety and Economic Feasibility: A Review of Soil Fluorine Management Strategies in South Korea

Chang-Hwan Ji, Soon Hong Lee, Gi Seong Bae, Hyun Woo Kim

Subject: Environmental And Earth Sciences, Soil Science Keywords: Fluorine; pollution; bioavailability; soil management standards

Online: 11 July 2024 (09:59:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2527.v1

Updated Risk Assessment of Cannabidiol in Foods based on Benchmark Dose-Response Modeling

Eva Wisotzki, Heike Franke, Constanze Sproll, Stephan G. Walch, Dirk W. Lachenmeier

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: cannabidiol; novel food; health-based guidance value; benchmark dose; risk assessment

Online: 31 July 2024 (09:50:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1133.v1

Development of Aptamer-Based Gold Nanoparticle Lateral Flow Test Strips for Detection of SARS-CoV-2 S Protein on the Surface of Cold Chain Food Packaging

Xiaotong Li, Jiachen Wang, Xiaona Fang, Lianhui Zhao, Zhaofeng Luo, Yiyang Dong

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; S protein; COVID-19; lateral flow test strips; AuNPs; aptamer

Online: 20 February 2024 (11:55:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0339.v1

A Crucial Role of Proteolysis in Formation of Intracellular Dinitrosyl Iron Complexes

Karolina E. Wójciuk, Jarosław Sadło, Hanna Lewandowska, Marcin Kruszewski

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: K562 cells; electron paramagnetic resonance; nitric oxide; reactive nitrogen species; dinitrosyl iron complexes; chelatable iron; glutathione

Online: 6 February 2024 (13:33:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0202.v1

Objective and Perceived Risk in Seismic Vulnerability Assessment at Urban Scale

Eliana Fischer, Alessio Emanuele Biondo, Annalisa Greco, Francesco Martinico, Alessandro Pluchino, Andrea Rapisarda

Subject: Engineering, Civil Engineering Keywords: Seismic vulnerability; Urban areas; Objective risk; Perceived risk

Online: 14 July 2022 (03:25:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2046.v1

Seismic Damage Assessment of Existing Planar Steel X or V-Braced Frames Using the Hybrid "M and P" Technique

Triantafyllos Makarios, Athanasios Bakalis, Evangelos Efthymiou

Subject: Engineering, Civil Engineering Keywords: Damage identification; Steel Braced Frames; Concentric X or V-bracing; Stepping Eigenfrequencies; Capacity Curve; Target Displacement

Online: 29 August 2024 (02:52:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0465.v1

Seismic Assessment of 10-Story Building Using Tuned Mass Damper

Mohammad Aghajani Delavar

Subject: Engineering, Civil Engineering Keywords: tuned mass damper; passive control; seismic analysis; energy dissipation; tall buildings; state-space equations of motion

Online: 29 May 2020 (12:41:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0966.v1

Natural Fiber-reinforced Mycelium Composite for Innovative and Sustainable Construction Materials

Maristella E. Voutetaki, Anastasios C. Mpalaskas

Subject: Engineering, Architecture, Building And Construction Keywords: mycelium-based material; mycelium composites; fungi; construction biomaterial; natural fibers; fiber-reinforced mycelium

Online: 14 June 2024 (11:26:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0941.v1

Electrolyte Imbalance in Acute Traumatic Brain Injury: Insights from the First 24 Hours

Alina Săcărescu, Mihaela-Dana Turliuc

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: traumatic brain injury; electrolytes; early monitoring; Glasgow Coma Scale; chloride; potassium

Online: 13 August 2024 (14:39:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0151.v1

Fragility Assessment of Container Crane under Seismic Excitation Considering Uplift and Derailment Behavior

Quang Huy Tran, Jungwon Huh, Nhu Son Doan, Van Ha Mac, Jin-Hee Ahn

Subject: Engineering, Civil Engineering Keywords: STS container crane; uplift and derailment; time history analysis; pushover analysis; fragility assessment

Online: 15 September 2019 (06:26:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0736.v1

Tea Grounds as a Waste Biofiller for Natural Rubber

Aleksandra Juszkiewicz, Magdalena Maciejewska

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: tea grounds; natural rubber; tea waste; biofiller; ionic liquids

Online: 13 March 2024 (11:56:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0074.v1

Diversity of HPV 16 L1 in the Asian Region: A Comparative Analysis of Sequences

Rana Özdoğan, Muharrem Okan Çakır, G Hossein Ashrafi, Uğur Bilge

Subject: Biology And Life Sciences, Virology Keywords: Human Papillomavirus, HPV 16, L1, Phylogenetic analysis

Online: 3 March 2024 (18:18:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0011.v1

Simulation Analysis of Solution Transportation Absorption Chiller with the Capacity from 25 RT to 1000 RT

Koji Enoki, Fumi Watanabe, Seigo Tanaka, Atsushi Akiwawa, Toshitaka Takei

Subject: Engineering, Energy And Fuel Technology Keywords: absorption chiller; thermal energy transportation; solution transportation; ammonia-water; COP; simulation

Online: 4 February 2017 (07:49:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0704.v1

Rapid Visual Screening Feature Importance for Seismic Vulnerability Ranking via Machine Learning and SHAP values

Ioannis Karampinis, Lazaros Iliadis, Athanasios Karabinis

Subject: Engineering, Civil Engineering Keywords: Rapid Visual Screening; Explainable AI; Feature Importance; SHAP

Online: 12 February 2024 (14:53:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1304.v2

Seismic Vulnerability Assessment at Urban Scale by Means of Machine Learning Techniques

Gugliemo Ferranti, Annalisa Greco, Alessandro Pluchino, Andrea Rapisarda, Adriano Scibilia

Subject: Engineering, Civil Engineering Keywords: Seismic vulnerability; Urban areas; Machine learning; Risk maps

Online: 20 December 2023 (09:06:14 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201607.0078.v2

Analysis between Various Random MIMO Systems Model on the Basis of Channel Capacity

Shree Krishna Acharya

Subject: Engineering, Electrical And Electronic Engineering Keywords: MIMO system Model; 2N–MIMO system model; Outage Probability; Channel Capacity Ratio (CCR)

Online: 10 August 2016 (10:11:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0542.v1

Development of an HPLC Method through the QbD Approach for the Quantification of Honokiol and Metformin Hydrochloride – Method Validation and Pharmaceutical Applications on Oral Dosage Forms

Mousa Sha’at, Adrian Florin Spac, Iulian Stoleriu, Alexandra Bujor, Monica Stamate Cretan, Mihaela Hartan, Lăcrămioara Ochiuz

Subject: Medicine And Pharmacology, Pharmacy Keywords: QbD optimization; HPLC; validation; greenness; assay; dissolution test; metformin hydrochloride; honokiol; oral dosage forms; diabetes mellitus.

Online: 9 July 2024 (06:08:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1217.v1

Tightness of Harary Graphs

Abolfazl Javan, Ali Moeini, Mohammad Shekaramiz

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Network Vulnerability; Tightness; Harary Graphs; Connectivity; Hamiltonian Circuit

Online: 16 August 2024 (08:37:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0049.v1

A New Input Device for Spastics Based on Strain Gauge

Niels Buchhold, Christian Baumgartner

Subject: Engineering, Control And Systems Engineering Keywords: tactile sensors; assistive technologies; power wheelchair; medical systems; robotic; joystick; strain-gauge; spasticity

Online: 14 February 2017 (09:02:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0608.v1

Seismological Problem, Seismic Waves and the Seismic Mainshock

Bogdan Felix Apostol

Subject: Physical Sciences, Mathematical Physics Keywords: primary seismic waves; seismic mainshock; elastic wave equation; seismic tensorial force; regularization

Online: 8 August 2023 (07:17:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0128.v1

Screening for Triterpenoid Saponins in Plants Using Hyphenated Analytical Platforms

Bekzod Khakimov, Li Hong Tseng, Markus Godeljohann, Søren Bak, Søren Balling Engelsen

Subject: Biology And Life Sciences, Plant Sciences Keywords: time slice LC-SPE-NMR/MS; GC-MS; LC-MS/MS; triterpenoid saponins; Barbarea vulgaris

Online: 25 November 2016 (10:04:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1768.v1

Pilot Testing of Useful Tools Validity for Frailty Assessment in Greece: Translated PRISMA-7 Tool, Modified Fried Criteria and Clinical Frailty Scale

George Soulis, Efstathia Kyriakopoulou, Aristea Leventouri, Eleni Zigkiri, Vasiliki Efthymiou, Zikos Kentros, Anastasia Koutsouri

Subject: Public Health And Healthcare, Primary Health Care Keywords: Frailty; Greek Translation of PRISMA-7; Modified Fried criteria; Greek version of Clinical Frailty Scale

Online: 28 March 2024 (12:12:26 CET)

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The importance of frailty in older people is getting constant recognition as an important aspect both in terms of public health, as well in personal level for the appropriate management of an older person health condition. This is reflected by the continuously increasing number of research studies carried out in several settings across different countries. Sometimes this is very solid, but in other cases there is a considerable gap in terms of accurate and well grounded documentation of frailty status. This is the case in Greece, where we are missing clinically validated tools to approach frailty. We are missing frailty screening tools, such as for instance PRISMA 7, the gold standard tool of Fried criteria is somehow problematic since the question referring to physical activity originates from a questionnaire that has not been translated and validated, while Clinical Frailty Scale has been validated for the translation but not for the capacity to detect frailty. Aim of this study is to validate these tools for their accuracy to detect frailty by using a measurable index of frailty, previously proposed for use in clinical studies: the Short Physical Performance Battery (SPPB). 74 male and female participants have been evaluated for their frailty status using different tools. We observed that PRISMA 7 translation detects frailty only when one question is removed at a cut-off of ≥ 2 and indicated a sensitivity of 88.1%, and specificity of 99.9% with a good correlation with SPPB measurements (r = 0.858; p < 0.001). When CFS was validated using SPPB it demonstrated a very good correlation (r = -0.838; p < 0.001 respectively) as it was the case for the modified Fried Criteria (r = -0.725; p < 0.001). All items demonstrated a good correlation between them. We can here propose that we can accurately assess frailty status in the community setting by using a modified version of Fried criteria, Clinical Frailty Scale translation in Greek and we can screen for frailty by using the Greek translation of PRISMA 7 only after removing the item 6 of the questionnaire.

Preprint ARTICLE | doi:10.20944/preprints201608.0018.v1

Soil Tillage Systems and Wheat Yield in Climate Change Scenarios

Pieranna Servadio, Simone Bergonzoli, Claudio Beni

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: soil tillage; tractors; soil water content; physical soil properties; GPS; energy requirement; CO2 emission

Online: 2 August 2016 (12:50:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1056.v1

Circulating miR-16 and miR-21 Levels in Multiple Myeloma: Prognostic Significance of Survival and Response to Lenalidomide Treatment.

Annita Ioanna Gkioka, Maria Tsota, Aspasia Koudouna, Alexandros Gkiokas, Christina Aggeliki Mitropoulou, Aikaterini Palaiokrassa, Alexandros Alexandropoulos, Mavra Papadatou-Gigante, Vasiliki Bartzi, Thomais Marina Tryfou, Petros P Sfikakis, George V. Dedoussis, Marie Christine Kyrtsonis

Subject: Biology And Life Sciences, Life Sciences Keywords: Multiple myeloma, miR-16, miR-21, prognosis, lenalidomide, serum expression level, downregulation.

Online: 16 April 2024 (12:01:38 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.0309.v1

Histological, Clinical Assessment, and Treatment of a Complication after 16 Years of a Permanent Filler in the Upper Lip: A Case Report

Samuel Fiuza, Tiago Marques, Irving Padin, Maria Teresa Carvalho, Nélio Veiga, Juliana Campos Hasse Fernandes, Gustavo Vicentis Oliveira Fernandes, Patrícia Couto

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Filler; complication; silicone; polymethylsiloxane; lip augmentation; facial esthetics

Online: 6 March 2024 (10:57:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0525.v1

Zebra_K, a Kinematic Analysis Automated Platform for Assessing Sensitivity, Habituation and Prepulse Inhibition of the Acoustic Startle Response in Adult Zebrafish

Marija Stevanovic, Niki Tagkalidou, Cristiana Roberta Multisanti, Sergi Pujol, Ouwais Aljabasini, Eva Prats, Caterina Faggio, Josep M. Porta, Demetrio Raldúa

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: acoustic startle response; neuroplasticity; habituation; prepulse inhibition; sensorimotor gating; adult zebrafish; kinematic analysis platform

Online: 6 September 2024 (12:09:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0333.v1

The Relationship between Job Strain and Ischemic Heart Disease, Mediated by Endothelial Dysfunction Markers and Imaging

PALOMA MOISII, IRINA JARI, ANDRA MARA URSU, ALEXANDRU GRATIAN NAUM

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronary artery disease; cardiovascular risk; job strain; high sensitivity C reactive protein; microalbuminuria

Online: 4 April 2024 (09:16:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0229.v1

Numerical Coupling between a FEM Code and the FVM Code OpenFOAM by Using the MED Library

Sandro Manservisi, Giacomo Barbi, Antonio Cervone, Federico Giangolini, Lucia Sirotti

Subject: Engineering, Energy And Fuel Technology Keywords: CFD; Code coupling; Conjugate Heat Trasfer

Online: 3 April 2024 (08:09:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1035.v1

The Hydroxyapatite-Filled Acrylonitrile-Butadiene Rubber Composites with Improved Cure Characteristics and Reduced Flammability

Magdalena Maciejewska, Przemysław Rybiński, Anna Sowińska-Baranowska

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: acrylonitrile-butadiene rubber; hydroxyapatite; filler; flammability; silane; ionic liquid; surfactant; vulcanization; dispersibility

Online: 12 July 2024 (12:08:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1334.v1

New Spectrophotometric Visible (VIS) Analysis to determine Sodium Valproate from Tablets

CRISTIAN-CATALIN GAVAT

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Sodium valproate; antiepileptic drug; spectrophotometric quantitative analysis method; light yellow azo dye; official declared pure amount; quantitative color reaction; statistical validation procedure

Online: 19 August 2024 (14:27:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1994.v1

A Study on the Calculation of TEQ and MEQ of 16 PAHs in Kuwait’s Crude Oil-Contaminated Soil and Ecotoxicity Assessment of Bioluminescent Bacteria

Jaemin Lee, Byeongwook Choi, Haein Yang, Kyoungjin Lee, Taeyeong Heo, Eunhea Jho, Deokjong Song, Sungjong Lee

Subject: Environmental And Earth Sciences, Pollution Keywords: Crude oil-contaminated Soil; PAHs; Bioluminescent bacteria; Ecotoxicity assessment

Online: 29 August 2023 (13:16:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0374.v1

Patients’ Satisfaction regarding Oral Healthcare Services in the North-East Region of Romania: A Questionnaire Survey

Silviu Catalin Tibeica, Dragoș Ioan Virvescu, Iulian Costin Lupu, Dana Gabriela Budala, Ionut Luchian, Andreea Tibeica, Zinovia Surlari, Elena Mihaela Carausu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: oral health; dental management; quality of life; patient satisfaction; quality management; dental services

Online: 4 April 2024 (12:14:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2495.v1

Development of Geotechnical Seismic Isolation System in the Form of Vertical Barriers: Effectiveness and Perspective

Yerik T. Bessimbayev, Assylbek S. Shadkam, Ulugbek T. Begaliev, Meyram M. Begentayev, Dossym K. Suleyev, Zhanar O. Zhumadilova, Tuleukhan I. Irgebayev, Yerlan Y. Ussipbekov

Subject: Engineering, Architecture, Building And Construction Keywords: earthquake; seismic; ground dynamics; response spectrum; barriers; geotechnical seismic isolation; rubber-soil mixture; damping

Online: 31 July 2024 (08:00:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0731.v1

Seismic Performance Assessment of Composite Frame – High-Strength Steel Plate Wall Core Tube Resilient Structure System

Lei Zhang, Cuikun Wang, Caihua Chen, Mingzhe Cui

Subject: Engineering, Civil Engineering Keywords: high-performance structural system; high strength steel; ultra-high strength concrete; double steel plate concrete composite shear wall; seismic resilience assessment

Online: 11 December 2023 (15:58:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0520.v1

Α Rapid Seismic Damage Assessment (RASDA) tool for RC Buildings based on an Artificial Intelligence Algorithms

Konstantinos Morfidis, Sotiria Stefanidou, Olga Markogiannaki

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Seismic damage assessment; Artificial Neural Networks; Pattern Recognition; Software Development; RC Buildings

Online: 30 March 2023 (03:09:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0192.v1

Based on Historical Seismic Damage Data to Rapidly Assessment the Vulnerability of Structures in Rural Village

Xinqiang Yao, Bin Liang, Baitao Sun, Wuping Gao

Subject: Social Sciences, Safety Research Keywords: rural village; earthquake; vulnerability index; vulnerability analysis; damage matrix

Online: 10 November 2021 (08:26:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2295.v1

Application of Experimental Configurations of Seismic and Electric Tomographic Techniques to the Investigation of Complex Geological Structures

Vasileios Gkosios, John D. Alexopoulos, Konstantinos Soukis, Ioannis-Konstantinos Giannopoulos, Spyridon Dilalos, Dimitrios Michelioudakis, Nicholas Voulgaris, Thomas Sphicopoulos

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: ERT; SRT; seismic sources comparison; spectral analysis; forward modelling; GPR; magmatic intrusion

Online: 29 July 2024 (11:01:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1365.v1

Rifampicin Loaded PLGA/Alginate Grafted pNVCL-Based Nanoparticles for Wound Healing

Tudor Bibire, Daniel Vasile Timofte, Radu Dănilă, Alina Diana Panainte, Cătălina Natalia Yilmaz, Nela Bibire, Luminita Agoroaei, Cristina Mihaela Ghiciuc

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: alginate; NVCL; nanoparticle; rifampicin; IC50; wound healing

Online: 19 September 2024 (08:43:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0497.v1

Effectiveness of a Polyphenolic-Enriched Blend on Weight Management and Metabolic Syndrome-Related Parameters in Healthy, Overweight Adults

Alejandro Martínez-Rodríguez, Maria Martínez-Olcina, Manuel Vicente-Martínez, Nuria Asencio-Mas, Pau Navarro, Nuria Caturla, Jonathan Jones

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Hibiscus sabdariffa; Lippia citriodora; weight management; satiety; body fat; cholesterol

Online: 8 April 2024 (07:03:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0332.v1

Differential protective effect of zinc and magnesium for the hepatic and renal toxicity induced by acetaminophen and potentiated with ciprofloxacin in rats

Alexandra Moraru (Ciocan), Diana C. Ciubotariu, Cristina Mihaela Ghiciuc, Catalina Elena Lupusoru, Mihnea Eudoxiu Hurmuzache, Radu Crișan-Dabija

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: magnesium chloride (MgCl2); zinc gluconate (ZnG); liver diseases; kidney diseases

Online: 6 March 2024 (13:55:48 CET)

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Background: The purpuse was to investigate the influence induced by magnesium chloride (MgCl2) and zinc gluconate (ZnG) supplementation on liver and kidney injuries experimentally-induced with acetaminophen (AAPh) and potentiated by ciprofloxacin addition in rats. Material and methods: The experiment was performed on 5 animals groups: group 1 – control, treated for 6 weeks with normal saline, 1mL/kg; group 2 – AAPh, treated for 6 weeks with AAPh, 100 mg/ kg/day; group 3 – AAPh+C, treated AAPh 100 mg/kg/ day for 6 weeks and ciprofloxacin, 50mg /kg/day, only in the last 14 days of the experiment; group 4 – AAPh+C+Mg, with the same treatment as group 3, but, and in the last 14 days, MgCl2 10 mg/ kg/day was added; group 5 – AAPh+C+Zn, with the same treatment as group 3, but, and in the last 14 days, zinc gluconate (ZnG),10 mg/kg/day was added. All administrations were performed by oral gavage. At the end of the experiment, the animals were sacrificed and blood samples were collected for biochemistry examinations. Results: Treatment with AAPh for 6 weeks determined an alteration of the liver function (increases in alanine aminotransferase, aspartate aminotransferase, lactic dehydrogenase and, and gamma-glutamyl transferase) and of renal function (increases in serum urea and creatinine) (P < 0.001 group 2 vs. group 1 for all mentioned parameters). Also, the antioxidant defense capacity was impaired in group 2 vs. group 1 (superoxide dismutase and glutathione peroxidase activity decreased in group 2 vs. group 1, 0.001 < P < 0.01, respectively 0.01 < P < 0.05). The addition of ciprofloxacin, 50 mg/kg/day during the last 14 days resulted in further increases in alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, urea and creatinine (0.01 < P < 0.05, group 3 vs. group 2). MgCl2 provided a slight protection against liver enzymes increase and a more pronounced protection against the increase in serum urea and creatinine (0.001 < P < 0.01 group 4 vs. group 3). MgCl2 provided a slight protection against the decrease in superoxide dismutase (0.01 < P < 0.05 group 4 vs. group 3), but not against decrease of glutathione peroxidase. The improvement of mentioned parameters could also be seen in case of ZnG, to a higher extent especially in the case of alanine aminotransferase and lactic dehydrogenase (0.01 < P < 0.05 group 5 vs. group 4). Conclusions: This study represents a furthermore proof for beneficial effect of magnesium and zinc salts against toxicity induced by different agents, including antibacterials added to the analgesic and antipyretic acetaminophen; the protection is proven on the liver and kidney’s function; the antioxidant profile improvement has a key role, especially in case of zinc gluconate.

Preprint ARTICLE | doi:10.20944/preprints202405.2007.v1

Computing Interface Curvature from Height Functions using Machine Learning with a Symmetry-preserving Approach for Two-phase Simulations

Antonio Cervone, Sandro Manservisi, Ruben Scardovelli, Lucia Sirotti

Subject: Engineering, Energy And Fuel Technology Keywords: curvature computation; volume of fluid; height function; machine learning; neural network

Online: 30 May 2024 (10:58:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0638.v1

Immobilization of Cell Walls with Laccase in L-DOPA-Alginate Beads and Investigation of the Influence of Photopolymeriza-Tion on the Temperature Stability of Immobilized Cells and Their Ability for Textile Dye Decolorization

Nikolina Popović Kokar, Anamarija Nikoletić, Marija Stanišić, Milica Crnoglavac Popović, Radivoje Prodanović

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: algae biomass; alginate; yeast cells; laccase; surface display; hydrogel; photopolymerisation; bioremediation

Online: 9 April 2024 (13:08:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0146.v1

Full-scale Assessment of Seismic and Wind Load Performance in the Design of a Flexible Solar-Shading Double-Skin Façade

José Pérez-Fenoy, Carlos Rivera-Gómez, Jorge Roa-Fernández, Carmen Galán-Marín

Subject: Engineering, Architecture, Building And Construction Keywords: Double skin façade; Permeable cable-supported façade; Ceramic masonry façade; Full-scale wind and earthquake testing; Impact testing

Online: 2 November 2023 (10:33:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0584.v1

“Prevalence of Dental Caries and Dietary Determinants among 12–16 Years Old Students, a Cross-Sectional Study”

Suela Hoxha, Fatime Hoxha, Jaser Veseli, Xheneta Hoxha

Subject: Public Health And Healthcare, Other Keywords: DMFT; soft drinks; frequency; adolescents

Online: 9 May 2024 (10:34:04 CEST)

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Introduction: Caries is a public health problem in Kosovo among children, Caries is a multifactorial microbial disease and connection of this disease with soft drinks and food habits between children and their poor oral health is very strong. Aim: The aim of present study is to evaluate prevalence of caries among 12 to 16 years old students in municipality of Suhareka and to analyze related risk factors that contribute in occurrence of caries. Material and methods: To observe parameters of soft drink we used experimental method and a cross-sectional study was carried out among 120 adolescents in “Sadri Duhla” elementary school in Duhel and “7 Marsi” elementary school in city of Suhareka. Oral clinical examination and self administered questionnaire were used to collect information about dental caries and its correlation to soft drinks and food habits. Examination was done between May and October in the year 2023. Impact of soft drink in caries was assessed through DMFT index and frequency of consumption of soft drinks. The data were collected statistically using SPSS version 26 and presented in tables and graphs. Results: The highest result of DMFT (4.36) with standard deviation 1.23 was noted in the group consuming more than 16 cans per week also the highest score in adolescent compared to frequency of consumed cans per week. Soft drinks found in Kosovo’s mar-kets are acidic with low pH, 93.75% of them had a pH below 4 which are considered erosive and only 6.25% are minimally erosive with a pH > 4, in terms of buffer capacity soft drinks can be ordered like this energy drinks >soda >100% fruit juice > fruit drinks. Improper tooth-brushing, dental visits only in case of pain and not preventive visits were significantly related to dental caries. Conclusion: The results of the research awarned us for high frequency consumption of soft drinks related to dental caries. It is recommended to be aware of the use of soft drinks, regular visits to the doctor, higher maintenance of oral health by using paste with sufficient fluoride content also brushing teeth 1 hour after consuming acidic food.

Preprint ARTICLE | doi:10.20944/preprints202305.0630.v1

Advanced Video-Based Processing for Low-Cost Damage Assessment of Buildings under Seismic Loading in Shaking Table Tests

Antonino Cataldo, Ivan Roselli, Vincenzo Fioriti, Fernando Saitta, Alessandro Colucci, Angelo Tatì, Felice Carlo Ponzo, Rocco Ditommaso, Canio Mennuti, Alessandro Marzani

Subject: Engineering, Civil Engineering Keywords: video-based; structural damage; low-cost method

Online: 9 May 2023 (09:52:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0233.v1

Seismic Performance Assessment of RC Moment Frames Considering Stiffness Modification in Nonlinear Concentrated Plasticity Formulation for Modeling Damping

Negar Mohammadgholibeyki

Subject: Engineering, Automotive Engineering Keywords: Concentrated plasticity; damping; rotational stiffness; seismic performance; collapse capacity; loss estimation

Online: 9 July 2021 (16:18:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1008.v1

Comparison of Optogalvanic and Laser-Induced Fluorescence Spectroscopy

Laurentius Windholz

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: Lanthanide spectroscopy; Optogalvanic detection; Laser-induced fluorescence detection

Online: 19 February 2024 (07:46:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201607.0051.v1

Search for QPOs in the Light Curve of the Blazar OJ287: Preliminary Results from 2015/16 Observing Campaign

S. Zola, M. Valtonen, G. Bhatta, A. Goyal, B. Debski, A. Baran, J. Krzesinski, M. Siwak, S. Ciprini, A. Gopakumar, H. Jermak, K. Nilsson, D. Reichart, K. Matsumoto, K. Sadakane, K. Gazeas, M. Kidger, V. Piirola, F. Alicavus, K.S. Baliyan, A. Berdyugin, D. Boyd, M. Campas Torrent, F. Campos, J. Carrillo Gomez, D.B. Caton, V. Chavushyan, J. Dalessio, D. Dimitrov, M. Drozdz, A. Erdem, A. Escartin Perez, V. Fallah Ramazani, A.V. Filippenko, F. Garcia, F. Gomez Pinilla, M. Gopinathan, J.B. Haislip, J. Harmanen, G. Hurst, K.M. Ivarsen, M. Jelinek, A. Joshi, M. Kagitani, N. Kaur, N. Karaman, W.C. Keel, A.P. LaCluyze, B.C. Lee, E. Lindfors, J. Lozano De Haro, J.P. Moore, R. Naves Nogues, A.W. Neely, R.H. Nelson, W. Ogloza, S. Okano, J.C. Pandey, M. Perri, P. Pihajoki, G. Poyner, J. Provencal, T. Pursimo, A. Raj, R. Reinthal, S. Sadegi, T. Sakanoi, J.-L. Salto Gonzales, T. Schweyer, F.C. Soldan Alfaro, E. Sonbas, I. Steele, J.T. Stocke, J. Strobl, L.O. Takalo, T. Tomov, L. Tremosa Espasa, J.R. Valdes, J. Valero Perez, F. Verrecchia, J.R. Webb, M. Yoneda, M. Zejmo, W. Zheng, J. Telting, J. Saario, T. Reynolds, A. Kvammen, E. Gafton, R. Karjalainen, P. Blay

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies: active; BL Lacertae objects: individual (OJ 287); super massive black holes

Online: 18 July 2016 (10:46:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1387.v1

Study on the Design of a New Three-Dimensional Seismic Isolation Bearing Based on Improved Genetic Algorithm for Bridge Engineering

Ying Sheng, Zhenchao Yang, Yu Meng, Bin Jia

Subject: Engineering, Civil Engineering Keywords: three-dimensional seismic isolation bearing; bridge engineering; sensitivity of the design parameters; improved genetic algorithm; good seismic isolation effect

Online: 18 September 2024 (11:12:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0017.v1

Nonlinear Modeling of RC Substandard Beam-Column Joints for Building Response Analysis in Support of Seismic Risk Assessment and Loss Estimation

Naveed Ahmad, Muhammad Rizwan, Babar Ilyas, Seda Hussain, Muhammad Usman Khan, Hamna Shakeel, Muhammad Ejaz Ahmad

Subject: Engineering, Civil Engineering Keywords: beam-column joint; fibre-based section modeling; joint shear hinge; substandard beam-column joints; stiffness and strength deterioration; reinforced concrete; seismic vulnerability; risk

Online: 4 October 2022 (10:38:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0978.v1

Seismic Design and Analysis of a Cold-Formed Steel Exoskeleton for Retrofit of a RC Multi-story Residential Building

Emilia Meglio, Antonio Formisano

Subject: Engineering, Civil Engineering Keywords: Integrated retrofit; Steel exoskeletons; Existing buildings; Reinforced Concrete structures; Design method; Pushover analyses

Online: 13 August 2024 (14:55:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0034.v1

Simultaneous Quantification of 16 Bisphenol Analogues in Food Matrices

Fiorella Lucarini, Rocco Gasco, Davide Staedler

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: bisphenol analogues; canned foods; food matrices; QuEChERS; GC-MS; LC-MS/MS; endocrine disruptors

Online: 3 July 2023 (09:35:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1136.v1

Mismatch Responses to Speech Contrasts in Preschoolers With and Without DLD

Ana Campos, Jyrki Tuomainen, Outi Tuomainen

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: DLD; multifeature paradigm; mismatch response; ERPMMR time-frequency analysis

Online: 17 November 2023 (04:36:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0154.v1

MgAl Oxide Coatings Modified with CeO2 Particles Formed by Plasma Electrolytic Oxidation of AZ31 Magnesium Alloy: Photoluminescent and Photocatalytic Properties

Stevan Stojadinović, Nenad Radić

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: plasma electrolytic oxidation; photocatalysis; photoluminescence, MgO, MgAl2O4, methyl orange

Online: 6 March 2024 (04:01:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1275.v1

Numerical Algorithms for Divergence-Free Velocity Applications

Giacomo Barbi, Antonio Cervone, Sandro Manservisi

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: divergence-free velocity; Raviart-Thomas finite elements; mass conservation

Online: 16 July 2024 (10:15:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.2061.v1

Combining Translation Readthrough Inducing Drugs and Nonsense Mediated Decay Pathway Inhibition to Rescue of CFTRW1282X in Cystic Fibrosis Cell Model System

Roberta Bongiorno, Emanuele Vitale, Davide Ricci, Pietro Salvatore Carollo, Ivana Pibiri, Raffaella Melfi, Andrea Pace, Laura Lentini

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: premature termination codon; nonsense mutation; Nonsense-mediated decay; translational readthrough inducing drugs; oxadiazoles.

Online: 29 June 2024 (00:09:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0429.v1

Timber-Based Strategies for Seismic Collapse Prevention and Energy Performance Improvement in Masonry Buildings

Davide Cassol, Maja Danovska, Alessandro Prada, And Ivan Giongo

Subject: Engineering, Civil Engineering Keywords: unreinforced masonry; seismic retrofit; energy efficiency; timber panels; timber strong-backs; thermal transmittance u-value; periodic thermal properties; transient method; response factors

Online: 7 November 2023 (09:32:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0073.v1

On the Seismic Design of Structures with Tilting Located within a Seismic Region

Federico Valenzuela-Beltrán, Sonia E. Ruiz, Alfredo Reyes-Salazar, J. Ramón Gaxiola-Camacho

Subject: Engineering, Civil Engineering Keywords: structural reliability; asymmetric yielding behavior; seismic risk analysis; seismic design; structural tilting

Online: 13 November 2017 (03:04:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0705.v1

Rapid Growth of Population, GDP, and Built-up Land Exposed to High Seismic Hazard in Large Cities, China

Huiduo Wang, Qiang Dong, Weijiang Li, Jiahong Wen, Qing Wu, Yanming Chen, Jianli Liu, Li Li

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Earthquake; Exposure; High Seismically Hazardous Zone; Large City; China

Online: 11 June 2024 (15:40:05 CEST)

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In the context of rapid urbanization, the spatiotemporal patterns of socio-economic exposed to high seismic hazard in large cities lacks quantitative assessment, thus, it is difficult to understand the evolution of earthquake catastrophe risk there. In this paper, exposure change rate, and absolute and relatively exposure indices were proposed to quantitatively study the changes of spatiotemporal exposure to high seismic hazard in urban areas of large cities (i.e., permanent residents in urban areas more than 1 million) in Chinese mainland, using a set of multi-temporal population, GDP, and built-up datasets and a seismic hazard zoning map. The results show that, 64 out of 78 large cities are entirely or partially located in high seismically hazardous zones. Although the urban areas of large cities in high seismically hazardous zones (HSHUAs) cover only 1.73% (167177 km²) of mainland China, their share of population, GDP, and built-up land amounted to 18.14%, 30.24% and 24.55%, respectively, in 2015. Unprecedented urbanization has led to a dramatic exposure growth in HSHUAs between 1990 and 2015. The population, GDP, and built-up land in HSHUAs increased by 110 million people (with an average annual growth rate of 2.37%), 273.71 trillion USD(average annual growth rate of 11.15%), and 10593 km2 (average annual growth rate of 2.02%), respectively. HSHUAs experienced much faster population and GDP growth than the whole country, while relatively slower growth in built-up land. Exposure growth in HSHUAs also was varied for different types of large cities. Megacities had a higher proportion of increased GDP and population in HSHUAs, induced by industry and population agglomeration. Whereas, Type II large cities had a higher proportion of increased built-up land in HSHUAs, driven mainly by urban sprawl. Our analysis indicates that, for large cities under rapid urbanization, it is an urgent need to strengthen resilient urban planning, renewal and construction.

Preprint ARTICLE | doi:10.20944/preprints201908.0308.v1

All Things Being Equal: Spatiotemporal Differences between Open and Women’s 16-Goal Polo

Russ Best, Regan Standing

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: horse; equine; Polo; GPS; horse welfare

Online: 29 August 2019 (08:37:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1357.v1

Where Are Planar 0-Vertex Graphs Hiding?

jan turulski

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: chemical graph; planar graph; Euler's formula; invariant states

Online: 19 August 2024 (14:02:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0129.v1

Extraction and Purification of Catechins from Tea Leaves: An Overview of Methods, Advantages, and Disadvantages

Oana Cioanca, Ionut-Iulian Lungu, Ioana Mita-Baciu, Silvia Robu, Ana Flavia Burlec, Monica Hancianu, Florina Crivoi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: catechins; HPLC; extraction methods; purification; tea polyphenols

Online: 2 April 2024 (07:40:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0019.v1

Semelparity and Reproductive Death in Caenorhabditis elegans

David Gems, Carina Kern, Joseph Nour, Marina Ezcurra

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; biomass conversion; C. elegans; reproductive death; semelparity; senescent pathology

Online: 2 November 2020 (10:45:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1732.v1

Anti-Proliferative and Cytoprotective Activity of Ethylenediurea Derivatives with Alkyl and Oxygen-containing Groups as Substituents

Maxim S. Oshchepkov, Leonid Kovalenko, Antonida Kalistratova, Galina Sherstyanykh, Evgenia Gorbacheva, Alexey Antonov, Karina Ustinova, Nisreen Khadour, and Mikhail Akimov

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: carbamates; oxamates; synthetic cytokinins; substituted ureas; anti-oxidative effect; cytotoxicity; oxidative stress

Online: 27 May 2024 (10:27:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1091.v1

River Habitat Survey (RHS) method in the assessment of synecological characteristics of macroinvertebrates: Aquatic Heteroptera of the River Krąpiel valley

Grzegorz Michoński, Andrzej Zawal, Grzegorz Tończyk, Wojciech Płaska, Joanna Pakulnicka, Vladimir Pešić, Michał Grabowski, Aleksandra Bańkowska, Agnieszka Szlauer-Łukaszewska, Robert Stryjecki, Magdalena Achrem, Iga Lewin, Zuzanna Krzynówek, Maja Krakowiak, Stanisław Musielak, Tapas Chatterjee, Edyta Stępień-Zawal

Subject: Biology And Life Sciences, Aquatic Science Keywords: hydromorphology; hydromorphological indexes; water bugs; landscape scales, physico--chemical parameters

Online: 17 April 2024 (07:51:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1053.v1

Mechanical Assessment of Denture Polymers Processing Technologies

Cristina Modiga, Andreea Stoia, Marius Traian Leretter, Anca Tudor, Virgil-Florin Duma, Andreea-Violeta Ardelean, Edward-Ronald Azar, Gabriel Kapor, Daniela-Maria Pop, Mihai Rominu, Cosmin Sinescu, Meda-Lavinia Negrutiu, Emanuela-Lidia Craciunescu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: denture polymers; processing technologies; polymers injection; 3D printing; mechanical testing; CAD-CAM

Online: 15 May 2024 (14:03:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0214.v1

Level of Agreement between Plaque Detection with Clinical Assessment and Assessment on Intraoral Scanner

Grigoria Gkavela, Pia Norrisgaard, Christos Rahiotis

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Level of agreement; intraoral scanner; plaque; disclosing agent; plaque index

Online: 5 August 2024 (09:32:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2216.v1

Hypofractionated Post-Prostatectomy Radiotherapy in 16 Fractions: A Single Institution Outcome

Pavol Dubinsky, Vladimir Vojtek, Katarina Belanova, Natalia Janickova, Noemi Balazova, Zuzana Tomkova

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: prostate cancer, moderate hypofractionation, post-prostatectomy radiotherapy

Online: 30 June 2023 (10:30:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0026.v1

Basin Resonance and Seismic Hazard for Jakarta, Indonesia

Athanasius Cipta, Phil Cummins, Masyhur Irsyam, Sri Hidayati

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: seismic hazard; openquake; GMPE; basin-induced amplification; SPECFEM2D

Online: 4 January 2018 (10:04:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201607.0056.v1

Dynamic simulation of urban expansion based on cellular automata and logistic regression model: Case study of Hyrcanian region of Iran

Meisam Jafari, Seyed Masoud Monavari, Hamid Majedi, Ali Asghar Alesheikh, Mirmasoud Kheirkhah Zarkesh

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Land use change; urban sprawl; Logistic regression; Markov chain; Cellular automata; Gilan Province

Online: 18 July 2016 (11:53:16 CEST)

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Although, promotion of urbanization culture in recent decades has made inevitable development of cities in the world, however, the development can be guided in a direction that leave, to the extent possible, minimum socioeconomic and environmental impacts. For this, it is required to first forecast auto-spreading orientation of cities and suburbs in rural areas over time and then avoid shapeless growth of cities. This paper is an attempt to develop a dynamic hybrid model based on logistic regression (LR), Markov chain (MC), and cellular automata (CA) for prediction of future urban sprawl in fast-growing cities. The model was developed using 12 widely-used urban development criteria, whose significant coefficient was determined by logistic regression, and validated by relative operating characteristic (ROC) analysis. The validated model was run in Guilan, a tourist province in northern Iran with a very high rate of urban development. For this, changes in the area of urban land use were detected over the period of 1989 to 2013 and then, future sprawl of the province was forecasted by the years 2025 and 2037. The analysis results revealed that the area of urban land use was increased by more than 1.7 % from 36012.5 ha in 1989 to 59754.8 ha in 2013, and the area of Caspian Hyrcanian forestland was reduced by 31628 ha. The results also predicted an alarming increase in the rate of urban development in the province by the years 2025 and 2037, during which urban land use is predicted to develop 0.9 % and 1.38 %, respectively. The development pattern is expected to be uneven and scattered, without following any particular direction. The development will occur close to the existing or newly-formed urban basements as well as around major roads and commercial areas. This development, if not controlled, will lead to the loss of 13863 ha of Hyrcanian forests and if the trend continues, 21013 ha of Hyrcanian forests and 20208 ha of Barren/open lands are expected to be destroyed by the year 2037. In general, the proposed model is an efficient tool for the support of urban planning decisions and facilitates the process of sustainable development of cities by providing decision-makers with an overview on future development of cities where the growth rate is very fast.

Preprint ARTICLE | doi:10.20944/preprints202409.0860.v1

Development and Pilot Study of myfood24 West Africa — an Online Tool for Dietary Assessment in Nigeria

Chinwe Adaugo Uzokwe, Chiaka Charles Nkwoala, Bassey Ebenso, Sarah Beer, Grace Williams, Gideon Iheme, Chihurumnanya Opara, Rasaki Sanusi, Henrietta Nkechi Ene-Obong, Janet E Cade

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Food composition tables; energy intake; nutrition assessment; nutrition app; usability study; digital tool; diet monitoring

Online: 11 September 2024 (07:32:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0748.v1

Cause Analysis of Salinity Intrusion by Environmental Changes considering Water Intake and Sand Mining on Seomjin River Estuary Using EFDC Model for Maintaining Corbicula Habitats

Chunggil Jung, Gayeong Lee, Jongyoon Park

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Seomjin River; salinity intrusion; EFDC; saltwater stratification; estuarine environmental challenges; corbicula

Online: 13 February 2024 (13:10:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0503.v1

Formulation and Evaluation of Hydrophilic Matrix Tablets for Controlled Released Chlorzoxazone Delivery

Andreea Creteanu, Gabriela Lisa, Cornelia Vasile, Maria-Cristina Popescu, Daniela Pamfil, Claudiu N. Lungu, Gladiola Tantaru, Alina Diana Panaite

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: chlorzoxazone; collided; chitosan; matrix tablets; controlled release

Online: 8 April 2024 (07:15:31 CEST)

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The release of the active substance from the matrix modified-release tablets based on Kollidon®SR and chitosan depends on its solubility in the dissolution medium and on the composition of the matrix-forming polymers. The study is based on new oral matrix tablets based on Kollidon®SR and chitosan, formulated to optimize the low oral bioavailability of chlorzoxazone, a non-steroidal anti-inflammatory drug, a class II Biopharmaceutical Classification System. Nine types of chlorzoxazone matrix tablets were obtained using the direct compression method, and their combination at 1:1, 1:2, 1:3 chlorzoxazone/ excipients, 20%-40% (w/w) Kollidon®SR, 3-7% (w/w) chitosan and the auxiliary substances were formulated in constant concentrations. Pharmaco-technical characterization included the analysis of flowability and compressibility properties (flow time, friction coefficient, angle of repose, Hausner ratio, Carr Index), and of pharmaco-chemical characteristics (mass and dose uniformity, thickness, diameter, mechanical strength, Friability, degree of softening, in vitro release profile) of the tablets. Based on the initial evaluation of the pharmaco-technical analysis, pharmaco-chemical characteristics, and in vitro release profile, only three matrix tablet formulations (F1b, F2b, and F3b) were further tested. They were evaluated through Fourier-transform infrared spectrometry, X-ray Diffraction, thermogravimetry, differential scanning calorimetry, and in vitro dissolution tests. The three formulations were comparatively studied regarding the release kinetics of active substances using in vitro release testing. The results were analyzed by fitting into four representative mathematical models for the modified release oral formulations. In vitro kinetic study reveals a complex mechanism of release occurring in the first (0 - 2 hours) and second (2.0 hours – 36 hours) steps of drug release. Two factors have been calculated to assess the release profile of chlorzoxazone: f1 - the similarity factor and f2 - the factor difference. The results have shown that both Kollidon®SR and chitosan may be used as matrix-forming agents when combined with chlorzoxazone. In vitro dissolution tests revealed the F2b sample, data suggesting a faster drug release. The three formulations showed optimum pharmaco-technical properties and in vitro kinetic study, and they had tremendous potential to be used in oral pharmaceutical products for the controlled delivery of chlorzoxazone.

Preprint ARTICLE | doi:10.20944/preprints202402.1590.v1

Possible Interrelations of Space Weather and Seismic Activity: An Implication for Short-term Earthquake Prediction

Valery Sorokin, Victor Novikov

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: solar flare; geomagnetic field variations; geomagnetically induced currents; electromagnetic earthquake triggering; aerosol emission; short-term earthquake prediction

Online: 28 February 2024 (09:39:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0983.v1

Brain Tumor Detection using the VGG-16 Model: A Deep Learning Approach

Dheiver Santos

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: brain tumor detection; VGG-16 model; convolutional neural network; MRI imaging; deep learning

Online: 14 August 2023 (08:34:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1484.v1

Assessment of SLAM Scanner Accuracy for Outdoor and Indoor Surveying Tasks

Zahra Gharineiat, Fayez Tarsha Kurdi, Krish Henny, Hamish Gray, Aaron Jamieson, Nicholas Reeves

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: SLAM; LiDAR; accuracy assessment; indoor and outdoor; data acquisition

Online: 23 April 2024 (11:59:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0120.v1

β-Glucans and Post Prandial Satiety: The Role of Intestinal Hormones in Healthy Volunteers

Sara Baldassano, Silvio Buscemi, Anna Aiello, Giulia Accardi, Calogero Caruso, Sonya Vasto

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: β-glucans; entero-endocrine system; intestinal hormones; microbiota; nutritional intervention

Online: 23 December 2016 (13:37:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1611.v1

Evaluation of Galectin-3 in Dogs with Atrial Fibrillation

Giulia Arcuri, Carlotta Valente, Giovanni Romito, Federico Bonsembiante, Chiara Mazzoldi, Barbara Contiero, Helen Poser, Carlo Guglielmini

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: canine; biomarker; cardiac disease; echocardiography

Online: 20 July 2024 (11:47:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0174.v1

Synergizing Systems Thinking and Technology-Enhanced Learning Using the Flow Theory Framework

Brina Kurent, Stanislav Avsec

Subject: Social Sciences, Education Keywords: systems thinking; higher-order thinking; student engagement; technology-enhanced learning; flow; optimal experience; sustainable education

Online: 3 September 2024 (07:29:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0456.v2

Quantitative Image Processing for Three-Dimensional Episcopic Images of Biological Structures: Current State and Future Directions

Natalie Aroha Holroyd, Claire Walsh, Lucie Gourmet, Simon Walker-Samuel

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: episcopic; imaging; microscopy; annotation; quantification

Online: 6 March 2023 (13:52:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0382.v1

Experimental Study on Seismic Performance of CFRP Strengthened Recycled Concrete Columns with Different Levels of Seismic Damage

Shuai Song, Zhen Tian, Zhenyu Zhao, Xi Li, Jianfeng Zhao, Baishun Xu

Subject: Engineering, Civil Engineering Keywords: carbon fiber composites; recycled concrete; recycled aggregate replacement rate; levels of seismic damage; pseudo-static test

Online: 6 May 2023 (05:32:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0272.v1

Study of The Seismic Stress State of the "Subgrade - Base" System, Taking Into Account the Formation and Propagation of Surface Seismic Waves

Saulet Shayakhmetov, Algazy Zhauyt

Subject: Engineering, Civil Engineering Keywords: surface seismic waves; numerical experiment; horizontal; Fourier transforms; half-spaces

Online: 16 January 2023 (07:38:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1179.v1

Participation of Secondary School Learners Aged 14 to 16 Years in Organised Sport

Mohamed Ayyub Mia, Makhaya Malema, Lloyd Leach

Subject: Social Sciences, Education Keywords: Participation; secondary school learners; organised sport; adolescent; sport clubs

Online: 18 July 2023 (07:52:20 CEST)

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Background: In South Africa, a relatively small number of children and adolescents belong to sports clubs, and adolescent participation in organised sport has steadily declined, especially in recent years. Participation levels in organised sport has decreased during late childhood and, more increasingly, as adolescents grow older. Aim: Therefore, the aim of this study was to determine the participation of secondary school learners aged 14 to 16 years in organised sport. Methods: The study was a quantitative and descriptive, cross-sectional design. The study sample was 329 conveniently sampled secondary school learners, males, and females, aged 14 to 16 years from three state schools in Cape Town, Western Cape Province. A researcher-generated, self-administered questionnaire on organised sport participation was developed, piloted, and validated among 44 learners of similar background, who did not participate in the main study. The statistical software, SPSS version 27, was used to capture and analyse the research data. The level of statistical significance for the study was set at p < 0.05. Results: A total of 66.9% of participants in the study sample participated in organised sport. Low but significant correlations were reported between gender and participation in organised sport (r = 0.22; p < 0.001), gender and friend participation in organised sport (r = 0.24; p < 0.001), participants participation and sibling participation in organised sport (r = 0.23; p < 0.001), participants participation and friend participation in organised sport (r = 0.36; p < 0.001), and between participant participation and parental participation in organised sport (r = 0.17; p = 0.003). Conclusion: Adolescent participation in organised sport was lower in the present circumstances compared to participation in the past three years. Adolescent males had higher participation levels in organised sport compared to adolescent females. There is an urgent need for solutions to counteract the low levels of adolescent participation in organised sport, especially in adolescent females.

Preprint ARTICLE | doi:10.20944/preprints202405.0511.v1

Cooperative Decay of an Ensemble of Atoms in a One-Dimensional Chain with a Single Excitation

Nicola Piovella

Subject: Physical Sciences, Optics And Photonics Keywords: Superadiance; subradiance; Cooperative emission

Online: 8 May 2024 (16:00:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1767.v1

Effects of LP on Immune Function and Intestinal Flora in Immunosuppressive Mice

Jiaqi Hou, Jiamei Hao, Min Zhong, Jianwu Ren, Wentao Xu, Xiaoyun He

Subject: Biology And Life Sciences, Food Science And Technology Keywords: lily polysaccharide; immunosuppression; intestinal flora

Online: 27 May 2024 (22:24:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0893.v1

Seismic Hazard Resilience in Montenegro: A Comprehensive Qualitative Analysis of Local Preparedness and Response Mechanisms

Vladimir M. Cvetković, Goran Grozdanić, Miško Milanović, Slobodan Marković, Tin Lukić

Subject: Social Sciences, Safety Research Keywords: disaster; seismic hazard; seismic resilience; Montenegro; qualitative analysis; local preparedness; response mechanisms; vulnerability assessment; public awareness

Online: 14 May 2024 (08:24:18 CEST)

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Working Paper ARTICLE

MzS Tools: GIS Methods and Tools for Seismic Microzonation Mapping

Giuseppe Cosentino, Francesco Pennica, Emanuele Tarquini, Giuseppe Cavuoto, Francesco Stigliano

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Python; QGIS plugin; geodatabase; Seismic microzonation; SpatiaLite.

Online: 7 September 2021 (11:53:51 CEST)

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Working Paper ARTICLE

Reliability of Seismic Performance Assessments for Individual Buildings and Portfolios

Charles Conrad Thiel Jr., Theodore C. Zsutty, Yajie J. Lee

Subject: Engineering, Automotive Engineering Keywords: Reliability; Earthquake damageability; Structural evaluation; Safety; Financial risk; MC simulation

Online: 14 May 2021 (13:46:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0319.v1

Between Life and Death: Reducing Phototoxicity in Super-Resolution Microscopy

Kalina L. Tosheva, Yue Yuan, Pedro M. Pereira, Siân Culley, Ricardo Henriques

Subject: Biology And Life Sciences, Other Keywords: Phototoxicity, Photodamage, Super-Resolution Microscopy, Fluorescence

Online: 30 August 2019 (08:22:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0585.v1

A Novel Approach to Compute Discrete Nonlinear Single Unit Activity Features

Nikita Zakharov, Elena Belova, Anna Gamaleya, Alexey Tomskiy, Alexey Sedov

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Entropy; mutual information; single unit activity; basal ganglia; subthalamic nucleus; Parkinson’ s disease

Online: 9 September 2024 (09:04:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0199.v1

Assessment of Adipocyte Transduction Using Different AAV Capsid Variants

Stanislav Boychenko, Alina Abdullina, Victor Laktyushkin, Andrew Brovin, Alexander Egorov

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: adeno-associated virus; viral tropism; adipocytes; adipose tissue; anti-obesity agents; gene therapy

Online: 5 August 2024 (07:11:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1238.v1

Seismic Velocity Inverse via Physics Embedded RNN

Cai Lu, Chunlong Zhang

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: velocity modeling; seismic waveform inversion; physical information neural network; causal sequence

Online: 21 November 2023 (06:33:26 CET)

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Seismic velocity inversion is one of the most critical issues in the field of seismic exploration and has long been the focus of numerous experts and scholars. In recent years, the advancement of machine learning technologies has infused new vitality into the research of seismic velocity inversion and yielded a wealth of research outcomes. Typically, seismic velocity inversion based on machine learning lacks control over physical processes and interpretability. Starting from wave theory and the physical processes of seismic data acquisition, this paper proposes a method for seismic velocity model inversion based on Physical Embedding Recurrent Neural Networks. Firstly, the wave equation is a mathematical representation of the physical process of acoustic waves propagating through a medium, and the finite difference method is an effective approach to solving the wave equation. With this in mind, we introduce the architecture of recurrent neural networks to describe the finite difference solution of the wave equation, realizing the embedding of physical processes into machine learning. Secondly, in seismic data acquisition, the propagation of acoustic waves from multiple sources through the medium represents a high-dimensional causal time series (wavefield snapshots), where the influential variable is the velocity model, and the received signals are the observations of the wavefield. This forms a forward modeling process as the forward simulation of the wavefield equation, and the use of error back-propagation between observations and calculations as the velocity inversion process. Through time-lapse inversion and incorporating the causal information of wavefield propagation, the non-uniqueness issue in velocity inversion is mitigated. Through mathematical derivations and theoretical model analyses, the effectiveness and rationality of the method are demonstrated. In conjunction with simulation results for complex models, the method proposed in this paper can achieve velocity inversion in complex geological structures.

Preprint ARTICLE | doi:10.20944/preprints202304.1036.v1

Spatial Correlations of Global Seismic Noise Properties

Alexey Lyubushin

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: seismic noise; wavelet-based entropy; wavelet-based Donoho-Johnston index; correlations; day length

Online: 27 April 2023 (04:30:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1286.v1

Interpretable Support Vector Machine and Its Application to Rehabilitation Assessment

Woojin Kim, Hyunwoo Joe, Hyun-Suk Kim, Daesub Yoon

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: interpretable support vector machine; muscle function assessment; nearest boundary problem; rehabilitation

Online: 19 August 2024 (12:21:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0948.v1

Risk Assessment for Linear Regression Models in Metrology

Dubravka Božić, Biserka Runje, Andrej Razumić

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: regression; consumer’ s risk; producer’ s risk; tolerance interval; measurement uncertainty

Online: 19 February 2024 (14:52:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1357.v1

Electrochemical DNA Biosensors with Dual Signal Amplification Strategy for Highly Sensitive HPV 16 Detection

Yuxing Yang, Yazhen Liao, Yang Qing, Haiyu Li, Jie Du

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Electrochemical Biosensor; High-risk human papillomavirus; Gold Nanoparticles; 3-Aminopropyltriethoxysilane

Online: 20 July 2023 (02:41:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0374.v1

Short hybrid floating-point formats based on 16-bit for FPGA-based arithmetic implementations

Mario Alfredo Ibarra-Carrillo, Herón Molina-Lozano, Jesús Yaljá Montiel-Pérez

Subject: Computer Science And Mathematics, Hardware And Architecture Keywords: Floating point, hybrid floating point, FPGA, numerical precision, accuracy, mixed-precision

Online: 6 July 2023 (07:54:48 CEST)

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