The ASEAN Community-based Tourism (CBT) Standard has been adopted by 10 ASEAN member states in 2016 in order to collectively promote ASEAN as a competitive community-based tourism destination. Among the ASEAN member states, Lao PDR (Laos), has a unique CBT development experience through collaboration with various international development agencies. Such history has brought about issues when ASEAN CBT Standard was implemented at to provincial and district levels in Laos, including concerns of related communities on the Standard being not easily applicable considering the state of tourism development. While the application of the regional standard is a significant issue to the tourism industries in the Member States, however, there has been a lack of studies regarding the dynamics of implementation of regional tourism standards at the national level. In order to fill the research gap, this study utilized in-depth interviews with seven executives with significant experiences from the government, international development agency, international organization, and the private sector. Interviewees projected a diversity of perspectives on enabling factors and challenges in implementing ASEAN Community-based Tourism Standard at the national level focusing on Laos, which showed the complexity of CBT dynamics. The results also revealed how regional standards can be further recognized and promoted to the key stakeholders of Laos, better accepted and utilized by end users, and possibly better customized according to the local circumstances. Findings of this study evidence that collaboration among key stakeholders and the expected role of these stakeholders are critical when implementing ASEAN CBT Standard.

Mass plays a strange multiple role in classical physics. This results in a difference between gravity and all other forces - a difference that stood at the beginning of Einstein's development of his general theory of relativity. The equivalence principle (EP) deals with homogenious gravitational fields, which, in fact, don‘t exist in nature. There is only an approximation for this field in Einstein-Lift possible for local situations. Nevertheless this EP can be true, because in classical formal binary logic there can be formulated a true conclusion from a wrong premise or assumption.

Combined radiation with hemorrhage (combined injury, CI), exacerbates hematopoietic acute radiation syndrome and mortality compared to radiation alone (RI). We evaluated the effects of RI or CI on blood cell depletion as a biomarker to differentiate the two. Male CD2F1 mice were exposed to 8.75 Gy γ- radiation (60Co). Within 2 h of RI, animals were bled under anesthesia 0% (RI) or 20% (CI) of total blood volume. Blood samples were collected at 4-5 h and days 1, 2, 3, 7, and 15 after RI. CI decreased WBC at 4-5 h and continued to decrease them until day 3; counts then stayed at the nadir up to day 15. CI decreased neutrophils, lymphocytes, monocytes, eosinophils and basophils more than RI on day 1 or day 2. CI decreased RBCs, hemoglobin and hematocrit on days 7 and 15 compared to RI, whereas Hemorrhage alone returned to the baseline on days 7 and 15. RBCs depleted after CI faster than post RI. Hemorrhage alone increased platelet counts on days 2, 3, and 7, which returned to the baseline on day 15. Our data suggest that WBC depletion may be a biomarker within 2 days post-CI and RBC depletion after 3 days post-CI.

Considering characteristics of high river density, special underlying surface in plain river network region, and municipal drainage system function, river network drainage unit model is proposed, which is defined as a region surrounded by main river or embankment. Flood storage variety and control projects regulation of small rivers in each unit is simulated. With drainage catchment as an object, according to its drainage capacity, simplified municipal drainage model was developed. Coupling river network drainage unit model, simplified municipal drainage model and 2D flood routing model, urban flood analysis model for plain tidal river network region was developed, which could be applied to analyzing flood from upstream river, storm surge and local rainfall. Demonstration research was carried out in Puxi flood protected area in Shanghai.

This paper presents laboratory devices on which experimental measurements were carried out to prove the validity of the assumption about the reduction of vibrations transmitted to the conveyor belt structure generated by the impact forces of falling material grains in the places of transfer or on the hoppers of conveyor belts. In order to limit damage to the conveyor belts caused by the impact of the sharp edges of material grains, conveyor belts are supported by impact rollers or impact rubber rods in the places of transfers and on the hoppers of belt conveyors. The flattened ends of the impact rollers are inserted into the grooves of steel brackets installed on the supports of the fixed conveyor idlers of a conventional design. In this paper, a special modification of the fixed conveyor idler is presented, which consists of inserting plastic brackets into the structurally modified roller axle holders of the fixed conveyor idler. Measurements were carried out on the first laboratory device, which showed that the specially modified fixed conveyor idler resulted in a higher damping of up to 15% of the impact forces of the falling weight on the rubberized hoop of the impact roller shell compared to the conventional fixed conveyor idler design. Measurements carried out on the second laboratory device show that the effective vibration velocity values detected at the points where the impact roller axis fits into the fixed roller table holder, i.e. points B and D, are higher than when using plastic brackets, up to 6% for a 108 mm diameter roller, compared to steel impact roller brackets.

Major (exo)planetary and satellite bodies seem to concentrate at intermediate areas of the radial 1 distributions of all the objects orbiting in each (sub)system. We show that angular-momentum transport during secular evolution of (exo)planets and satellites necessarily results in the observed intermediate accumulation of the massive objects. We quantify the ‘middle’ as the mean of mean motions (orbital angular velocities) when three or more massive objects are involved. Radial evolution of the orbits is expected to be halted when the survivors settle near mean-motion resonances and angular-momentum transfer between them ceases (gravitational Landau damping). This dynamical behavior is opposite in direction to what has been theorized for viscous and magnetized accretion disks, in which gas spreads out and away from either side of any conceivable intermediate area. We present angular momentum transfer simulations in few-body systems, and we calculate the tidal dissipation timescales and the physical properties of the mean tidal field in planetary and satellite (sub)systems.

Background: Despite their generally favorable prognosis, hepatic fibrosis remains a possible complication for hepatitis B virus (HBV) inactive carriers. This study aimed to estimate the prevalence of significant fibrosis and associated risk factors among Omani HBV inactive carriers. Methods: A retrospective study was conducted of 200 Omani HBV inactive carriers visiting a tertiary hospital in Muscat, Oman, between January 2017 and December 2018. Significant fibrosis (stage F2 or higher) was identified using two-dimensional shear-wave elastography. Baseline clinical, laboratory, and radiological data were analyzed to determine associations. Results: Of the total sample, 106 patients (53%) were male, and the mean age was 44.6 ± 9.3 years. The prevalence of significant fibrosis was 20% (n = 40). Male gender (p = 0.007), age ≥60 years (p = 0.024), and fatty changes in liver ultrasound (p = 0.044) were found to be independent factors for significant fibrosis. Conclusion: the prevalence of significant fibrosis was relatively high among a sample of Omani HBV inactive carriers, with several sociodemographic and clinical risk factors identified. Periodic assessment of liver function is needed for patients with these risk factors; moreover, routine biochemical parameters could be useful predictors of disease prognosis. Further research is recommended to substantiate these findings.

Groundwater flow and transport models are essential tools for assessing and quantifying the mi-gration of organic contaminants at polluted sites. Uncertainties in the hydrodynamic and transport parameters of the aquifer have a significant effect on model predictions. Uncertainties can be quantified with advanced sensitivity methods such as Sobol’s High Dimensional Model Reduction (HDMR) and Variogram Analysis of Response Surfaces (VARS). Here we present the application of VARS and HDMR to assess the global sensitivities of the outputs of a transient groundwater flow model of the Gállego alluvial aquifer which is located downstream the Sardas landfill in Huesca (Spain). The aquifer is subject to the tidal effects caused by the daily oscillations of the water level in the Sabiñánigo reservoir. Global sensitivities are analysed for hydraulic heads, aquifer/reservoir fluxes, groundwater Darcy velocity and hydraulic head calibration metrics. Input parameters in-clude aquifer hydraulic conductivities and specific storage, aquitard vertical hydraulic conductiv-ities, and boundary inflows and conductances. VARS, HDMR and graphical methods agree to identify the most influential parameters which for most of the outputs are the hydraulic conduc-tivities of the zones closest to the landfill, the vertical hydraulic conductivity of the most permeable zones of the aquitard, and the boundary inflow coming from the landfill. The sensitivity of heads and aquifer/reservoir fluxes with respect to specific storage change with time. The aquifer/reservoir flux when the reservoir level is high shows interactions between specific storage and aquitard conductivity. VARS and HDMR parameter rankings are similar for the most influential parameters. However, there are discrepancies for the less relevant parameters. The efficiency of VARS was demonstrated by achieving stable results with a relatively small number of simulations.

In this article, we calculate the deflection angle of tidal charged black hole (TCBH) in weak field limits. First we obtain the Gaussian optical curvature and then apply the Gauss-Bonnet theorem on it. With the help of Gibbons-Werner method, we are able to calculate the light's deflection angle by TCBH in weak field limits. After calculating the deflection angle of light, we check the graphical behavior of TCBH. Moreover, we further find the light's deflection angle in the presence of plasma medium and also check the graphical behavior in the presence of plasma medium. Moreover, we investigate the shadow of TCBH.For calculating the shadow, we first find the null geodesics around the TCBH and then find its shadow radius. We also obtain TCBH's shadow in the plasma medium. Hence, we discuss the shadow of the TCBH using the $M87^{*}$ parameters announced by the Event Horizon Telescope.

The Standard Model (SM) of particle physics successfully describes electromagnetic, weak, and strong forces but omits gravity. We introduce the Kinematrix Field Theory (KFT), integrating gravity into this fundamental force framework through a novel particle, the kinematon. This gauge boson, existing in both massless and massive forms, advances the SM's scope to address enigmas like dark matter and neutrino masses. We detail the mathematical structure of the KFT and establish Feynman rules for kinematon interactions with fermions and gauge bosons. The KFT, synergizing with the Higgs mechanism and general relativity, aspires to a unified quantum theory of gravity. We explore the kinematon's phenomenological implications and potential experimental signatures, forecasting significant advancements in fundamental physics and setting a course for future explorations in the SM.

Living cells are complex systems that may be characterized by fluids crowded by hundreds of different elements in particular by a high density of polymers; they are an excellent and challenging laboratory to study exotic emerging physical phenomena where entropic forces emerge from organization processes of many-body interactions. The competition between microscopic and entropic forces may generate complex behaviors like phase transitions that living cells may use to accomplish their functions. In the era of the big data, when biological information abounds but general principles and precise understanding of the microscopic interactions scarce, the entropy methods may offer significant information. In this work we develop a model where the thermodynamic equilibrium results from the competition between an effective electrostatic shortrange interaction and the entropic forces emerging in a fluid crowded by different size polymers. The target audience for this article are interdisciplinary researchers in complex systems, particularly in thermodynamics and biophysics modeling.

This study fabricated piezoelectric fibers of polyvinylidene fluoride (PVDF) with graphene using near-field electrospinning (NFES) technology. A uniform experimental design table U*7 (7^4 ) was applied, considering weight percentage (1-13 wt%), distance between needle and disk collector (2.1-3.9 mm), and applied voltage (14.5-17.5 kV). We optimized the parameters using electrical property measurements and the Kriging response surface method. Adding 13 wt% graphene significantly improved electrical conductivity, increasing from 17.7 μS/cm for pure PVDF to 187.5 μS/cm. The fiber diameter decreased from 21.4 μm in PVDF/1% graphene to 9.1 μm in PVDF/13% graphene. Adding 5 wt% graphene increased the β-phase content by 6.9%, reaching 65.4% compared to pure PVDF fibers. Material characteristics were investigated using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), contact angle measurements, and tensile testing. Optimal parameters included 3.47 wt% graphene, yielding 15.82 mV voltage at 5 Hz and 5 N force (2.04 times pure PVDF). Force testing showed a sensitivity (S) of 7.67493 log(mV/N). Fibers were attached to electrodes for piezoelectric sensor applications. Results affirmed enhanced electrical conductivity, piezoelectric performance, and mechanical strength. The optimized piezoelectric sensor could be applied to measure physiological signals, such as attaching it to the throat under different conditions to measure the output voltage. The force-to-voltage conversion facilitated subsequent analysis.

Laboratory experiments and natural phenomena investigations in this research series experimentally revealed the existence of gravitational repulsion force dependent on thermal energy content, pervading our surroundings both microscopically and macroscopically. This paper presents an alternative mathematical model of both gravitational repulsion and attraction forces between two gaseous molecules, validated by experimental data. The model is self-standing and independent of existing models built on idealistic assumptions. While existing models considered gravitational interaction as a single force, the presented experimental model considers it the resultant of two distinct forces: gravitational repulsion and attraction. When established experimental data on nitrogen, hydrogen, oxygen, water vapor, carbon monoxide and carbon dioxide were applied, the model performed, both analytically and experimentally: (1) confirming the existence of both gravitational repulsion and attraction forces among gas molecules, (2) demonstrating that the two forces follow Inverse-Cube relationship with the distance between molecules, (3) revealing that repulsion force is linearly proportional to the absolute temperature, thus filling the critical gap between energy and fundamental forces. Orders of magnitude of gravitational repulsion and attraction forces are very large compared to the gravitational force between gas molecules calculated according to the classical theory, enabling manipulation to achieve hitherto unknown outcomes and developments.

Tidal notches, long regarded as reliable indicators of mean sea level, have been extensively studied along carbonate coasts in the central Mediterranean Sea. Previous studies revealed a correlation between the genesis of tidal notches and tidal range, lithology, cliff foot depth and wave energy. In the 2020 Geoswim campaign at Lampedusa, the southernmost island of the Pelagie archipelago (Italy), 'anomalous' tidal notches were identified. Unlike normal notches observed elsewhere, those in Lampedusa's southern bays exhibited a particular behavior —constantly deepening in the inner part of the bays, reaching a maximum depth of approximately 30 cm below sea level and narrowing inwards. Similar phenomena were previously observed by [1] near Marseille (France) and in Gozo Island (Malta). Time-lapse images, alongside measurements of morphometric param-eters, were collected during the survey. Despite the rapid morphological changes of the notches within the bay, the tectonic stability of the studied areas was confirmed by literature and data. Our hypothesis indicates that a combination of marine factors, influenced by local meteomarine conditions driven by the local morphology of the small bays exposed to southern quadrants con-tribute to the formation of these unique landforms. The latter manifest higher lowering erosion rates slightly below mean sea level in sheltered areas, challenging conventional notions about tidal notch formation.

Using a three-dimensional, hydrostatic, primitive-equation ocean model, this study investigates the dynamics of lateral circulation in a partially stratified tidal inlet, the Barataria Pass in the Gulf of Mexico, over a 25.6-hour diurnal tidal cycle. Model performance is assessed against observational data. During flood tide, the lateral circulation exhibits the characteristics similar to that induced by differential advection, i.e., lateral flow consists of two counter-rotating cells and is convergent at the surface. The analysis of momentum balance indicates that, in addition to the pressure gradient and vertical stress divergence, nonlinear advection and horizontal stress divergence are also important contributors. During ebb phase, the lateral circulation is mostly eastward for the whole water column and persisting for almost the whole period. The surface divergence suggested by the differential advection mechanism lasts for a very short period, if it ever exists. The main momentum balance across most of the transect during ebb is between the along-channel advection of cross-channel momentum and pressure gradient. The sectional averaged lateral velocity magnitude during ebb is comparable to that during flood, which is different from the idealized numerical experiment result.

The cause of the systematic daily march of barometric pressure in the tropics, notably the late morning and late evening peaks seen almost every day at all locations, was a puzzle that persisted through the nineteenth and much of the twentieth centuries. The efforts to explain the physics of the prominent 12-hour solar tidal variation helped inspire some of the earliest developments in theoretical atmospheric dynamics and ultimately led in the 1960’s to a satisfactory dynamical theory for the atmospheric tides. These important theoretical developments followed the observational discoveries, which date to the late 18th and early 19th centuries, of the surprising character of the barometric daily march and of its resolution into solar and lunar period cycles. These important, if simple, discoveries emerged primarily from the efforts of European scientists to systematically study the environment in remote areas of the globe. The two key figures in initially advancing the scientific community’s understanding of the character of barometric tides were the great German polymath Alexander von Humboldt (1769-1859) and the French naturalist Robert de Lamanon (1752-1787), who each made their discoveries on their most famous and colorful scientific expeditions of their respective careers. This paper examines the history of the early observations of the barometric tide.

Cancer cells exhibit aberrant extracellular matrix mechanosensing due to altered expression of mechanosensory cytoskeletal proteins. Aberrant mechanosensing of the tumor microenvironment (TME) by cancer cells has been shown to be associated with cancer development and progression. Recent studies show that altered mechanosensing changes the mechanobiological properties of cells, and, in turn, cells become susceptible to mechanical perturbations. Due to an increasing understanding of cell biomechanics and cellular machinery, several approaches have emerged to target the mechanobiological properties of cancer cells and cancer-associated cells to inhibit cancer growth and progression. In this review, we summarize the progress that happened in the development of mechano-based approaches to target cancer by interfering with the cellular mechanosensing machinery and overall TME.

As shown in former papers, the nonadiabatic Heisenberg model presents a novel mechanism of Cooper pair formation generated by the strongly correlated atomic-like motion of the electrons in narrow, roughly half-filled "superconducting bands". These are energy bands represented by optimally localized spin-dependent Wannier functions adapted to the symmetry of the material under consideration. The formation of Cooper pairs is not the result of an attractive electron-electron interaction but can be described in terms of quantum mechanical constraining forces constraining the electrons to form Cooper pairs. There is theoretical and experimental evidence that only this nonadiabatic mechanism operating in superconducting bands may produce eigenstates in which the electrons form Cooper pairs. These constraining forces stabilize the Cooper pairs in any superconductor, whether conventional or unconventional. Here we report evidence that also the experimentally found superconducting state in bismuth at ambient as well as at high pressure is connected with a narrow, roughly half-filled superconducting band in the respective band structure. This observation corroborates once more the significance of constraining forces in the theory of superconductivity.

Aiming at the development of the application of massive and heterogeneous LEO constellations, the influence of typical perturbation forces on the orbit prediction of LEO satellites at different altitudes is analyzed. Firstly, the main perturbation force model of LEO satellites is introduced. Then experiments for analyzing the influence of orbit prediction on LEO satellites at different altitudes are designed. Finally, the influence of typical perturbation forces on the orbit prediction under different prediction durations by numerical analysis is assessed systematically, and the orbit prediction of LEO satellites with different non-spherical gravitational field orders, ocean tide orders and atmospheric density models were compared and calculated. The research results show that different orders of non-spherical gravitational fields should be considered when the altitude of satellites is different, the reasonable gravitational field orders for LEO satellites at 500km, 1000km, 1500km and 2000km under 1-hour forecast time are 140x140, 80x80, 60x60 and 40x40 orders, the reasonable orders of ocean tide perturbation for 1500km and 2000km satellites are 20x20 orders. Under the 24-hour forecast time, atmospheric resistance has a great influence on the precision of LEO satellites at orbit altitude below 1,000km. The forecast deviation of the LEO satellites orbit at 500km reaches 8751.576m. The difference of orbit precision between different atmospheric density models is in the meter level. The orbit deviation by the Standard Atmosphere 1976 and NRLMSISE 2000 atmospheric models respectively reaches 25.494m. Relevant conclusions provide support for the optimization and selection of dynamical models in high precision orbit determination and fast orbit prediction of LEO satellites.

Hox gene clusters are crucial in Embryogenesis. It was observed that some Hox genes are located in order along the telomeric to centromeric direction of the DNA sequence: Hox1, Hox2, Hox3…. These genes are expressed in the same order in the ontogenetic units of the Drosophila embryo along the Anterior-Posterior axis. The two entities (genome and embryo) differ significantly in linear size and in-between distance. This strange phenomenon was named Spatial Collinearity (SP). Later, it was observed that, particularly in the Vertebrates, a Temporal Collinearity (TC) coexists: first is Hox1 expressed, later Hox2 and even later Hox3,…,. According to a Biophysical Model (BM), pulling forces act at the anterior end of the cluster while a cluster fastening applies at the posterior end. Hox clusters are irreversibly elongated along the force direction. During Evolution, the elongated Hox clusters are broken at variable lengths thus split clusters may be created. An Empirical Rule was formulated distinguishing development due to a complete Hox cluster from development due to split Hox clusters. BM can ‘explain’ this Empirical Rule. In a spontaneous mutation where the cluster fastening is dismantled, a weak pulling force automatically shifts the cluster inside the Hox activation domain. This cluster translocation can probably explain the absence of Temporal Collinearity in Drosophila.

As an important part of coastal wetlands, tidal flats provide unique ecosystem services and functions. China's tidal flats are significantly threatened by industrialization, urbanization, aquaculture expansion and coastline reconstruction, and there is an urgent need for sustainable strategies to balance the protection and utilization of tidal flats. Remote sensing technology can realize large-scale spatiotemporal research of tidal flats, comprehensively improve the ecological environment of coastal zones, and help achieve the overall planning goals of major projects for the protection and restoration of important ecosystems in China. In this study, based on GEE (Google Earth Engine) platform, Sentinel-2 (MSI), Landsat 8 (OLI) and Landsat 9 (OLI-2) remote sensing images were used to construct multi-source intensive time series remote sensing image collection, combined with MSIC-OA algorithm. The tidal flat data of China in 2018 and 2023 are extracted and analyzed. The results show as follows: 1) The overall classification accuracy of the tidal flat in 2023 is 95.19%, and the Kappa coefficient is 0.89; In 2018, they were 92.77% and 0.83 respectively. 2) The total tidal flat area in 2018 and 2023 is 8300.34km2 and 8151.54km2, respectively, a decrease of 148.80km2; 3) In 2023, estuarine and bay tidal flats will account for 54.88% of the total area, and most of the tidal flats will be distributed near river inlets and bays; 4) In 2023, the total length of the coastline adjacent to the tidal flat is 10196.17km, of which the artificial shoreline accounts for 67.06%, and the development degree of the tidal flat is 2.04, indicating that most of the tidal flat has been developed and utilized. The research results provide valuable reference for the scientific planning and rational utilization of tidal flat resources in China.

Production of electricity using hydro-kinetic tidal turbines has many challenges that must to be overcome to ensure reliable, economic and practical solutions. Energy from flowing water is converted by a system comprising: the turbine rotor blades, a gearbox, an electrical generator, control systems, power electronics, export cables, and a connection to the electricity grid. To date these have often been modelled using simulations of independent systems, lacking bi-directional, real-time, coupling. This approach leads to critical effects being missed. Turbulence in the flow, results in large velocity fluctuations around the blades, causing rapid variation in the shaft torque and generator speed, and consequently in the voltage seen by the power electronics and consequently the export power quality. The resulting poor quality power may be unacceptable to the grid. Conversely, grid frequency and voltage changes can also cause the generator speed to change, resulting in changes to the shaft speed and torque and consequently changes to the lift and drag forces acting on the blades. Clearly, fully integrated, bi-directional, models are needed. Here we present two fully coupled models which use different approaches to model the hydrodynamics of rotor blades. The first model uses Blade Element Momentum Theory (BEMT), resulting in an efficient tool for turbine designers. The second model also uses BEMT combines this with an actuator line model of the blades coupled to an unsteady computational fluid dynamics (CFD) simulation. This simulation, implemented in OpenFOAM, uses an energy balance to compute the shaft speed. Both the BEMT and CFD models are coupled to an Open Modellica model of the electro-mechanical system. Both models have been used to simulate the performance of a 1.2m diameter, scale model, of a three bladed horizontal axis tidal turbine tested in the University of Edinburgh FloWave Ocean Energy Research Facility. The turbulent flow around the blades and the mechanical-electrical variables during the stable period of operation are analysed. Time series and tabulated average values of mechanical thrust, power, torque, and rotational speed as well as electrical variables of generator power, electromagnetic torque, voltage and current are presented for the coupled system simulation. The relationship between the mechanical and electrical variables and the results from both tidal turbine approaches are discussed. Our comparison shows that while the BEMT model provides an effective design tool (leading to slightly more conservative designs), the CFD/BEMT simulations provide more accurate predictions of the blade loads which can be especially important in assessing fatigue on the blades (though at an increased computational cost).

In this paper, we introduce new formulas for calculating the restoring and repulsive magnetic forces between two non-coaxial circular loops with parallel axes. These formulas are derived from a modified version of Grover’s formula for mutual inductance between the coils in question. Utilizing these formulas, we compute the restoring and repulsive magnetic forces between two non-coaxial thick coils of rectangular cross-sections with parallel axes. In these calculations, we apply the filament method and conduct investigations to determine the optimal number of subdivisions for the coils in terms of computational time and accuracy. The method presented in this paper is also applicable to all conventional non-coaxial coils, such as disks, solenoids, and non-conventional coils like Bitter coils, all with parallel axes. This paper emphasizes the accuracy and computational efficiency of the calculations. Furthermore, the new method is validated according to several previously established methods

Life sciences are increasingly benefiting from multidisciplinary research, combining biology, chemistry and physics. At their intersection, biothermodynamics applies the quantitative framework of thermodynamics to life processes and is a potentially interesting subject for life science students. Here a method is proposed to teach undergraduate life science students the basics of biothermodynamics, building and expanding on the concept of Gibbs energy learned as a part of the physical or general chemistry course. The discussion begins with the role of Gibbs energy as the driving force of metabolism and growth. Moreover, a biological example is proposed of the enthalpy-entropy combinations resulting in negative Gibbs energy, which should be interesting to life science students. Gibbs energy is then used to explain microorganism growth rates, using a simple thermodynamic growth model. Finally, multiplication of viruses is considered, including SARS-CoV-2, using Gibbs energy to explain the hijacking of host cell metabolism. Implementation of the proposed biothermodynamics material in classroom is discussed. The paper should be useful as material for making lectures for undergraduate students and as a starting point for anyone beginning to do research in biothermodynamics.

Volcanism powered by tidal forces inside celestial bodies can provide enough energy to keep important solvents for living systems in the liquid phase. Moreover, tidal forces and their environmental consequences may strongly influence habitability of planets and other celestial bodies and may result in special forms of live and living conditions. A prerequisite to calculate such tidal interactions and consequences is depending on simulations for tidal accelerations in a multi-body system. Unfortunately, from measurements in many extrasolar planetary systems only few physical and orbital parameters are well enough known for investigated celestial bodies. For calculating tidal acceleration vectors under missing most orbital parameter exactly, a simulation method is developed that is only based on a few basic parameters, easily measurable even in extrasolar planetary systems. Such a method as being presented here, allows finding a relation between the tidal acceleration vectors and potential heating inside celestial objects. Using values and results of our model approach to our solar system as a “gold standard” for feasibility allowed us to classify this heating in relation to different forms of volcanism. This “gold standard” approach gave us a classification measure for the relevance of tidal heating in other extrasolar systems with a reduced availability of exact physical parameters. We would help to estimate conditions for the identification of potential candidates for further sophisticated investigations by more complex established methods like viscoelastic multi-body theories. As a first example, we applied the procedures developed here to the extrasolar planetary system TRAPPIST-1 as an example to check our working hypothesis.

It is unclear whether military shoes (combat boots and sports shoes) attenuate loading rate or affect force transfer during walking. Therefore, this study compared ground reaction forces (GRF) related to impact and force transfer between combat boots, military sports shoes and running shoes. Ten army recruits walked over a walkway with two force plates embedded. GRF were measured when walking barefoot (for data normalization) and with combat boots, military sports shoes and running shoes. Loading rate, first and second peak forces and push-off rate of force were computed along with temporal analysis of waveforms. Reduced loading rate was observed for the running shoe compared to the combat boot (p = 0.02 and d = 0.98) and to the military sports shoe (p = 0.04 and d = 0.92). The running shoe elicited a smaller second peak force than the combat boot (p < 0.01 and d = 0.83). Walking with military shoes and combat boots led to larger force transfer then running shoes potentially due to harder material used in midsole composition (i.e. styrene-butadiene rubber). These results could lead to a potentially larger risk of injuries while long duration walking in military shoes and boots compared to traditional running shoes.

We investigate the influence of the Abrikosov vortex lattice on the Casimir force in a setup constituted by high-temperature superconductors subject to an external magnetic field. The Abrikosov lattice is a property of type II superconductors in which normal and superconducting carriers coexist and these latter define a periodic pattern with squared symmetry. We find that the optical properties determined by spatial redistribution of the superconducting order parameter induce Casimir forces with a periodic structure whose minimal strengths coincide with the vortex cores.

Treatment of the [AuCl(tetrahydrothiophene)] complex with 4-chloro-2-iodo-1-isocyanobenzene furnished the gold(I) compound [AuCl(CNC6H3-4-Cl-2-I)] (1). In the crystal structure of 1, the linear C–Au–Cl group is subject to the solid-state head-to-tail pairing which is determined by the aurophilic Au···Au and the rare π-holeCN···Cl interactions. These two types of structure-determining interactions are complementary to each other and the system of Au···Au and CCN···Cl contacts accomplishes 2D extended ladder-type architecture. In addition, the terminal I-atoms are involved in the three-center halogen bonding. Density functional theory calculations, employing a set of computational tools, verified the role of Au···Au and π-holeCN···Cl noncovalent bonds in the spectrum of noncovalent forces.

A method was developed to perform shape optimization of a tidal stream turbine hydrofoil using a multi-objective genetic algorithm. A bezier curve parameterized the refrence hydrofoil profoil NACA 63815. Shape optimization of this hydrofoil maximized its lift-to-darg ratio and minimized its pressure coefficient, thereby increasing the turbines power output power and improving its cavitation characteristics. The Elitist Non-dominated Sorting Genetic Algorithm (NSGA-II) was employed to perform the shape optimization. A comparative study of two-and three-dimensional optimizations was carried out. The effect of varing the angle of attack on the quality of optimized results was also studied. predictions based on two-dimensional panel method results was also studied. Preditions based on a two-dimensional panel method and on a computational fluid dynamics code were compared to experimental measurments.

Tidal stream energy is a low carbon energy source. Tidal stream turbines operate in a turbulent environment, and the effect of the structure between the turbine and seabed on this environment is not fully understood. An experimental study using 1:72 scale models based on a commercial turbine design was carried out to study the support structure influence on turbulence intensity around turbine blades. The study was conducted using the wave-current tank at LABIMA, University of Florence. A realistic flow environment (ambient turbulent intensity = 11%) was established. Turbulence intensity was measured upstream and downstream of a turbine mounted on two different support structures (one resembling a commercial design, the other the same with an additional vertical element), in order to quantify any variation in turbulence and performance between the support structures. Turbine drive power was used to calculate power generation. Acoustic Doppler Velocimetry was used to record and calculate upstream and downstream turbulence intensity. In otherwise identical conditions, performance variation of only 4% was observed between two support structures. Turbulent intensity at 1, 3 and 5 blade diameters, both upstream and downstream, showed variation up to 21% between the two cases. The additional turbulent structures generated by the additional element of the second support structure appears to cause this effect, and the upstream propagation of turbulent intensity is believed to be permitted by surface waves. This result is significant for the prediction of turbine array performance.

This paper first explains the theory of the origin of force from a new perspective, explaining that the origin of all forces is caused by the "missing of energy in the time dimension" (non-conservation in a certain period of time), and constructs a unified theory of force on this basis. Then, through the unified theory of force, the following phenomena are reinterpreted: (1) The common origin of the inverse square law of gravitation and electromagnetic force; (2) The origin of the repulsive force of electrons and protons at small distances; (3) The mystery of the rotation curve of galaxies and the new explanation of "dark matter"; (4) explain the origin of the magnetic field; (5) Predict that moving magnets have the same radiation effect as charged particles (electron magnetic moments also have radiation effects); (6) Reinterpret Maxwell's displacement current; (7) Reinterpret synchrotron radiation and bremsstrahlung; (8) Explain that the strong and weak forces are short-range forces; (9) Predict the true structure of black holes and the origin of gravitational waves;(10) Possible explanation for the origin of the speed of light.

In a search for a solution of the galaxy rotation problem, a novel view on cosmological gravity is developed. In this view, the origin of gravity is traced back to the basic nuclear field of energy, spread by quarks as elementary pointlike sources. This gives a common basis for gravity, electromagnetism, the strong nuclear force and the weak nuclear force. After a review on gravimagnetism and the causality problem of gravity, a hypothetical concept for the gravity field is proposed, which solves the rotation problem without the need to accept dark matter as the deus ex machina.

GDF5 gene is involved in the development of skeletal elements, synovial joint formation, tendons, ligaments, and cartilage. Several polymorphisms are present within the gene and two of them, rs143384 and 143383, have been reported as correlated with osteoarticular disease or muscle flexibility. The aim of this research is to verify if the worldwide distribution among human populations of rs143384 polymorphism has been shaped by selective pressure, or if it’s the result of random genetic drift events. Ninety-four individuals of both sexes, 18-28 years old, from Sardinia were analyzed. We observed the following genotype frequencies: 28.72% of homozygotes AA, 13.83% of homozygotes GG, and 57.45% of heterozygotes AG. Allele frequencies were 0.574 for allele A and 0.426 for alle G. Relationships between populations were verified by Multidimensional Scaling (MDS). Our data show: i) a clear heterogeneity within the African populations; ii) a strong differentiation between Africans and the other populations: iii) the Sardinian population is placed withing the European cluster. To reveal possible traces of selective pressure, Population Branch Statistic (PBS) was calculated; both SNPs rs143384 and 143383 have low PBS values, suggesting that there are no signals of selective pressure in those areas of the gene.

The Virtual Blade Model (VBM) is the implementation of the Blade element model (BEM). This was done by coupling the Blade Element Momentum theory equations to simulate rotor operation with the Reynolds Averaged Navier-Stokes (RANS) equation to simulate rotor wake and the turbulent flow field around it. Exclusion of actual geometry of blades causes lower computational cost (about 10 to 100 times). Also, due to simplifications in the meshing procedure, VBM is easier to set up than the models that consider the actual geometry of blades. One of the main unaddressed limitations of the VBM code was the constraint of modeling up to ten rotor zones within one computational domain. This paper provides a detailed and well-documented general methodology to develop a virtual blade model for simulation of ten-plus turbines within one computational domain to remove the limitation of this widely used and robust code. It is strongly believed that the technical contribution of this paper, combined with the current sky-rocketing advancement of available computational resources and hardware, would open the gates to simulate various engineering problems in the field of aerospace, clean energy, and many more.

In the early 2000s, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) emerged as a performant and relevant tool for identifying micro-organisms. Since then, it has become practically essential for identifying bacteria in microbiological diagnostic laboratories. In the last decade, it was successfully applied for arthropod identification allowing to distinguish vectors from non-vectors of infectious diseases. However, identification failures are not rare, hampering it widely use. Failure is generally attributed either to the absence of respective counter species MS spectra in the database, or to the insufficient quality of query MS spectra (i.e. lower intensity and diversity of MS peaks detected). To avoid matching errors due to non-compliant spectra, the development of a strategy for detecting and excluding outlier MS profiles became compulsory. To this end, we created MSProfileR, an R package leading to a bioinformatics tool through a simple installation, integrating the control quality system of MS spectra and an analysis pipeline including peak detection and MS spectra comparisons. MSProfileR can also add metadata concerning the sample that the spectra are derived from. MSProfileR has been developed in the R environment and offers a user-friendly web interface using the R Shiny framework. It is available on Microsoft Windows as a web browser application by simply navigation using the link of the package on the Github. MSProfileR is therefore accessible to non-computer specialists and is freely available to the scientific community. We evaluated MSProfileR using two datasets including exclusively MS spectra from arthropods. In addition to coherent sample classification, outlier MS spectra were detected in each dataset confirming the value of MSProfileR.

Drag-dominant tidal turbine energy holds tremendous clean energy potential but faces significant hurdles as unsuitability of Disk Actuator theory due to the varying swept blockage area, unaccounted bypass flow downstream interaction and rotor parasitic drag whereas Blade Element Momentum theory is computably effective for majorly 3-blade lift-dominated aerofoil. This study proposes a novel method to find the optimal TSR of any turbine with a cost-effective and user-friendly Moment Balancing algorithm to support robust tidal energy development. Performance analysis CFD study of Pinwheel and Savonius tidal turbines was carried out. Dynamic TSR matrix was developed with varying rotational speeds and fluid velocities for reliability, unlike previous works simulated at a fixed fluid velocity. Novel parameters such as thrust and idle moment are introduced as functions of only inlet fluid velocity and rotational speed respectively. These relationships are verified through regression analysis, and the turbines' net moment equations are established based on these parameters. Rotational speed was a reliable predictor for Pinwheel's idle moment, while inlet velocity was a reliable predictor for thrust moment in both models. The optimal (Cp, TSR) values for Pinwheel and Savonius turbines were (2.37, 0.223) and (0.63, 0.16) respectively, within an acceptable error range for experimental validation.

We analyzed the peak spring tidal current speeds, annual mean tidal power densities (TPD) and annual energy production (AEP) obtained from experiment 06.1, referred as the "HYCOM model" throughout, of the three dimensional (3D), global model HYCOM in an area covering the Baja California Pacific and the Gulf of California. The HYCOM model is forced with astronomical tides and surface winds alone, and therefore is particularly suitable to assess the tidal current and wind-driven current contribution to in-stream energy resources. We find two areas within the Gulf of California, one in the Great Island Region and one in the Upper Gulf of California, where peak spring tidal flows reach speeds of 1.1 meters per second. Second to fifth-generation tidal stream devices would be suitable for deployment in these two areas, which are very similar in terms of tidal in-stream energy resources. However, they are also very different in terms of sediment type and range in water depth, posing different challenges for in-stream technologies. The highest mean TPD value when excluding TPDs equal or less than 50 W/m² (corresponding to the minimum velocity threshold for energy production) is of 172.8 W/m², and is found near the town of San Felipe, at (lat lon) = (31.006 -114.64); here energy would be produced during 39.00% of the time. Finally, wind-driven currents contribute very little to the mean TPD and the total AEP. Therefore, the device, the grid, and any energy storage plans need to take into account the periodic tidal current fluctuations, for optimal exploitation of the resources.

Water hyacinth (Eichhornia crassipes) is an invasive species that has modified ecosystem functioning in the Sacramento-San Joaquin Delta (Delta), California, USA. Studies in lakes and rivers have shown that water hyacinth alters water quality. In tidal systems, such as the Delta, water moves back and forth through the water hyacinth patch so water quality directly outside the patch in either direction is likely to be impacted. In this study, we asked whether the presence or treatment of water hyacinth with herbicides resulted in changes in water quality in this tidal system. We combined existing datasets that were originally collected for permit compliance and long-term regional monitoring into a dataset that we analyzed with a before-after control-impact (BACI) framework. This approach allowed us to describe effects of presence and treatment of water hyacinth, while accounting for seasonal patterns in water quality. We found that although effects of treatment were not detectable when compared with water immediately upstream, dissolved oxygen and turbidity became more similar to regional water quality averages after treatment. Temperature became less similar to the regional average after treatment, but the magnitude of the change was small. Taken together, these results suggest that tidal hydrology exports the effects of water hyacinth upstream, just as river flow is known to transport the effects downstream, creating a buffer of altered water chemistry around patches. It also suggests that although water hyacinth has an effect on dissolved oxygen and turbidity, these parameters recover to regional averages after treatment.

Gedanken experiments illustrating exemplifications of the Landauer principle in the free falling Einstein elevator are treated. Double-well simplest information system embedded into the free falling elevator is addressed. Infinitesimal horizontal force applied to the particle m transfers it from position “0” to position “1”, emerging from the free falling double-well system confining mass m. When thermal noise is considered, the potential barrier of kBT should be surmounted for the erasing of one bit of information. Entropic forces arising in the free falling elevator are considered. The maximal change in the entropy of free-joint polymer chain attached to the free falling elevator is estimated as ΔSmax≅kB, and it is remarkably independent of the mass attached to the chain and the parameters of the chain itself. Free falling minimal Szilard engine is treated. The informational re-interpretation of the minimal Szilard process is shaped as follows: the energy kBTln2 necessary for erasing of 1 bit of information is spent for lifting up mass, whatever, is the value of this mass. Appropriate choice of frames enables elimination of gravity in the considered system; however elimination of the thermal noise (dissipation processes) by the same procedure is impossible.

In this paper, the columnar supramolecular aggregates of photosensitive star-shaped azobenzenes with benzene-1,3,5-tricarboxamide core and azobenzene arms are analysed theoretically applying a combination of computer simulation techniques. Without a light stimulus, the trans-stars build one-dimensional columns of stacked molecules during the first stage of the noncovalent association. These columnar aggregates represent the structural elements of more complex experimentally observed morphologies -- fibers, spheres, gels and others. Upon UV light exposure, the azobenzene arms isomerise from thermodynamically stable planar trans- to a metastable kinked cis-state influencing the aggregate morphology. Here, we determine the most favourable mutual orientations of the \textit{trans}-stars in the stack in terms of (i) the pi-pi distance between the cores lengthwise the aggregate, (ii) the star slipped displacements and (iii) the rotation promoting the helical twist and chirality of the aggregate by calculating the binding energy diagrams using density functional theory. The model predictions are further compared with available experimental data. The intermolecular forces responsible for the stability of the stacks made of trans-azobenzene stars in crystals are quantified using Hirshfeld surface analysis. Finally, to characterize the self-assembly mechanism of such stars in solution, we calculate the hydrogen bond lengths, the normalized dipole moment and the binding energies as the functions of the columnar length using molecular dynamics trajectories, and conclude about the cooperative nature of this process.

As a first step a unification of the gravitational with the electromagnetic interaction within a classical framework is proposed. It is based on a V₅-geometry, with x₅ = q/m. The sole source term is mechanical stress energy, positioned along x₅. The trajectories of test-bodies are placed in V₄ (x₅ = const)-slices. The resulting field equation couples a geometric G-tensor to mechanical stress energy, its momentum with respect to V₅ and the change of this momentum with proper time τ. The following step proceeds to the quantization of space-time to enable the formalization of elementary particles und strong interaction. This is complimented by the inclusion of spin and the weak force, leading finally to a grand total equation, the stationary version of which corresponds to Schroedinger´s equation, the instationary version to the Einstein equation of General Relativity.

Objectives The aim of this study was to measure the magnitude of forces in the joints of the lower limb whilst running barefoot and compare them to the forces generated whilst wearing running shoes with a thick midsole.MethodsTwenty-three volunteers who utilised running as their main sport or a training aid ran as training aid were included in this study. Each volunteer would run down a fourteen-meter-long corridor both barefoot and with running shoes. Forces for joints of the lower limb were collected using a Vicon motion analysis system and force plates. The joint forces for the ankles, knees and hips were taken as the largest joint force experienced during the stance phase and then averaged over five running trials.ResultsThere was significant reduction in the joint forces for the ankles, knees, and hips when barefoot running compared to the shod condition.ConclusionBarefoot running could be utilised to prevent both acute and degenerative injuries of the lower limb.

When dealing with galactic dynamics, or more specifically, with galactic rotation curves, one basic assumption is always taken: the frame of reference relative to which the rotational velocities are given is assumed to be inertial. In other words, fictitious forces are assumed to vanish relative to the observational frame of a given galaxy. It might be interesting, however, to explore the outcomes of dropping that assumption; that is, to search for signatures of non-inertial behavior in the observed data. In this work, we show that the very discrepancy in galaxy rotation curves could be attributed to non-inertial effects. We derive a model for spiral galaxies that takes into account the possible influence of fictitious forces and find that the additional terms in the new model, due to fictitious forces, closely resemble dark halo profiles. Following this result, we apply the new model to a wide sample of galaxies, spanning a large range of luminosities and radii. It turns out that the new model accurately reproduces the structures of the rotation curves and provides very good fittings to the data.

Commercial development of tidal stream energy is hampered by technical and financial challenges, and impeded by uncertainty about potential environmental effects that drive environmental risk assessments and permitting (consenting) processes. The effect of greatest concern for operational tidal stream energy devices is the potential for marine animals to collide with turbine blades, resulting in injury or death. Due to the turbulent and often turbid waters that frequently characterize tidal turbine sites, there is an absence of empirical evidence about collisions with marine animals. This paucity of observations often leads to risk-averse permitting decisions that further restrict the deployment of tidal energy devices that are needed to collect this evidence. This paper relies on the framework of stressors and receptors that is used widely in marine energy studies and outlines a stepwise probabilistic methodology that applies existing knowledge to further elucidate the risk to marine animals from operational tidal turbines. A case study using striped bass from the Bay of Fundy, Canada, accompanies the methodology, to partially demonstrate its application.

The cost effective design of tidal turbines requires a good estimation of the loading cycles and their extrema that are related to the unsteady fluctuations of the current velocity. Apart from the ambient turbulence, the main source of velocity fluctuations is the presence of surface waves. In the present study, we analyse the effect of waves propagating against the current on the performance and the loads of a twin vertical axis tidal turbine by an experimental approach at a 1/20 scale. Overall, the results show little or no effect of the waves on the average power and loads compared to the condition with current only, but a significant impact on their standard deviation that rises linearly with the waves amplitude. The drag, lift and pitching moment show extended ranges up to 7.5 times higher and extreme values exceedance by 60 to 100 % with irregular waves compared to the condition without waves. Those load and power fluctuation increase are fully due to the presence of waves as the coherence function between the rotor torque or the loads and the velocity spectra exceed 0.5 on the whole wave frequency bandwidth. The results also reveal a rotational sampling of the waves by the rotors that had also been observed on horizontal axis turbines. From a structural design point of view, the authors recommand to conduct tests in irregular wave conditions as the loads range and extreme values are 1.5 to 2 times higher than those encountered with regular waves of the same significant height and period.

The present study investigates the decision-making process of investors on the Pakistan Stock Exchange with regard to portfolio construction, explicitly focusing on the incorporation of ESG concerns. The present study employed SmartPLS and structural equation modeling (SEM) to quantitatively assess data received from a sample of 393 out of 400 respondents. Based on the available data, investors participating in the Pakistan Stock Exchange are notably impacted by ESG aspects. The findings of this study hold significance for emerging economy firms, regulators, and investors, both in terms of theoretical and practical ramifications. The study's findings demonstrate a clear indication of investors' significant emphasis on ESG matters. Furthermore, it provides valuable insights for stakeholders who are involved in the ever-evolving realm of sustainable finance within developing countries

This research deals with the processing of wood using a circular saw, which is associated with several risks and factors that affect the wood splitting process. One of them is the wear of the teeth of the saw blade and the change in the size of the cutting forces. The aim of this study is to compare real measured values and theoretical values when processing Norway Spruce wood, using two types of saw blades SK and HSS with a diameter of 600 mm and the number of teeth 54 and 56. Experimental measurements were carried out on a special test device with the possibility of moving the tested wood into the cutting devices and a simple saw blade replacement system. The results of the contributions show significant differences, based on defined factors, which are supported by FEM analysis of cutting forces in the process of cutting wood - when changing the design of the saw blade. The results of the experiment show that the cutting conditions (cutting speed, feed speed) do not have a significant effect on the size of the cutting forces. The theoretical and real stress values for HSS discs ranged from 14 to 22 MPa. Significantly larger differences were recorded for discs with SK, where the real values of the maximum stresses were around 14 MPa and the theoretical ones around 25 MPa. When cutting spruce with a disc with SK slices, the maximum values of the the-oretical cutting forces were in the range of 76 to 94 N and the maximum values of the measured cutting forces were in the range of 40 to 44 N.

Land use land cover change analysis is one of the most particular techniques to understand how land was used in the past, what types of changes are to be expected in the future, as well as the forces and processes behind the changes. Thus, the objective of this study was to investigate the land use land cover changes and its driving forces in Mago National Park, southern Ethiopia. Satellite image of Landsat5 TM (1988, 1998 and 2008) and Landsat8 OLI/TIRS (2018) with a time span of 30 years were employed. In addition, field observation, and social survey were conducted to study the drivers of land use land cover changes. QGIS 3.2 and SPSS (for social data analysis) software’s’ were used for satellite image processing, accuracy assessment, map preparation and descriptively analyze the driving forces of LULCC respectively. Supervised classification with maximum likelihood algorithm was conducted for satellite image analysis and generation of information using Quantum GIS 3.2 Post classification change detection method was applied to quantify the land use/land cover change. The result of the study indicated riverine forest, woodland, grassland, water body, degraded land and bare land as a major land use land cover class in the park. The result of land use land cover classification showed that in 1988 most of the study area was covered by woodland and grass land. In the first period (1988-1998), woodland, riverine forest, water body and bare land decreased by 6.76%, 37.98%, 22.37% and 70.14% respectively, while grass land, and degraded land increased by 16.11% and 85.67% respectively. In the second period, (1998 -2008), woodland, riverine forest and degraded land were decreased by 5.44%, 4.61%, and 80.74% respectively, while grass land, water body and bare land is increased by 14.74%, 3.76% and 52.58% respectively. From 2008-2018 riverine forest, grassland, water body and bare land decreased by 1.33%, 15.16% and 4.82% and 25.02% respectively, while woodland increased by 11.84%, and degraded land increased by 85.49% respectively. Riverine forest, water body, grass land and bare land showed decrement and that of woodland, degraded land indicated increment during study period. From 1988-2018, woodland, riverine forest, water body and bare land indicated decrement and the remaining grass land and bare land cover types indicated increment during study period. The result of social survey indicated that expansion of agriculture, human induced fire, overgrazing and hunting are proximate driving forces of the change in Mago National Park. Population pressure from a different area, poverty, decreased farmlands productivity; education, weak law enforcement and cultural factors are the major underlying causes of the observed changes. Therefore, proper land use planning, legal support, and strong law enforcement are the key recommendations to sustain natural resources of the study area.

The experimental results of forces and efforts derived from the opening of incisions in the orbital cavity in a pig’s head are presented in this article. The different areas of the incision openings are related to the needs at the incision procedure for a dacryocystorhinostomy. In terms of the experimental procedure, an origin and a plane are defined so as to allow the location of the opening of the incision. The incisions are retracted along an axis of said origin. This procedure has been based on the mathematical model developed for this work, which consists of a procedure for determining the behavior of an incision when a force is applied to retract the skin. The experimental data obtained, suggests the existence of an almost linear relationship between the increment of resistance in relation to the time obtained for each opening, the same of which is deemed to be consistent with the behavior of an elastic material.

Both drag and lift forces impact an inclined plane when it is dragged through a granular bed. In this paper, the following results have been obtained: the drag and lift forces grow with the velocity of motion; when the immersion depth is constant, the inclination angle has no effect on drag force, however, the lift force increases linearly with this inclination angle; the ratio of drag and lift forces is exactly equal to the tangent value of the inclined angle. In order to describe this physical process macroscopically, a continuum wedge model based on the Coulomb model is established to predict drag and lift forces. Particularly，the dynamic friction angle in the assumed shear band is predicted as a function of both inclined angle and moving velocity.

Three-dimensional (3D) facies and petrophysical models were generated from previously published data of carbonate strata in the Dam Formation (eastern Saudi Arabia) to quantitatively investigate, describe, understand, model, and predict the permeability anisotropy of tidal flat carbonate within a sequence stratigraphic framework. The resulting 3D models were used to conduct fluid flow simulations to demonstrate how permeability anisotropy influences the production of hydrocarbons and ultimately affects decisions concerning future drilling in the exploration and development of carbonate reservoirs that have tidal flat strata. The constructed 3D facies model consists of four lithofacies associations, two of which were grain-dominated associations and two of which were mud-dominated associations. These lithofacies associations varied spatially in four reservoir zones (zones 1 to 4), which represent two fourth-order sequences in the uppermost part of the Dam Formation. Zones 1 and 3 consist of transgressive parasequences, and zones 2 and 4 consist of the regressive parasequences of these sequences. The 3D porosity and permeability models have a coherent match with the distribution of the lithofacies and the stratigraphic framework of the Dam Formation. The results suggested that the permeability anisotropy in zones 1 and 3 is controlled by the occurrence of the grain-dominated lithofacies associated with tidal flat channels. This lithofacies association overlies the sequence boundaries of sequences 1 and 3, forms reservoir bodies with relatively high permeability values, and is elongated perpendicular to the shoreline of the depositional environments. In contrast, permeability anisotropy in zones 2 and 4 is thought to be controlled by the occurrence of the grain-dominated lithofacies associated with the oolitic shoal. This lithofacies association overlies the maximum flooding surface of sequences 2 and 4, forms reservoir bodies with relatively high permeability values, and is elongated parallel to the shoreline of the depositional environments. Fluid flow simulation results suggested that the trend in hydrocarbon production from the constructed 3D models depends on permeability anisotropy in each reservoir zone. Thus, recognizing trends in permeability anisotropy, which might be predicted using sequences stratigraphy, could help to identify potential areas for future drilling.

The kipping handstand push-up (kHSPU) is an exercise performed by many thousands of CrossFit participants. The safety of kHSPUs has been questioned because of vertical impacts upon the head. Here, we measured the axial loads placed upon the head during kHSPUs and sought to identify other factors that may place participants at risk of injury. 16 volunteers from a single gym performed 3 sets of up to 7 kHSPUs with their head and one hand contacting force platforms. Forces were recorded continuously and video recording were made while performing the exercises. The force profiles showed distinct landing and kipping peaks. Participants landed with more force than during their normal headstand, but less than their body weight. The force on the head was greatest during the "kip," and was usually more than body weight. Participants who reported pain following kHSPUs moved their head into extension during the exercises. Forces to the head during kHSPUs were below forces proposed for damage to the young male cervical spine, but overlapped those proposed for female cervical spines. While kipping handstand push-ups may be safe for young and previously uninjured male athletes, they may be unsafe for females and for those with previous injury or other compromising factors.

The vegetation types on the Qinghai-Tibet Plateau are complex and diverse, and the ecological environment is fragile and sensitive. It is very important to study the dynamic changes in vegetation and the main factors related to these changes to grasp the present state of the regional ecosystem, maintain the balance of the ecosystem and promote the sustainable development of the ecosystem. Therefore, this paper is based on SPOT/VEG NDVI (normalized difference vegetation index) data, land use data, topographic data and meteorological data from 1999 to 2019. The spatiotemporal variation in the NDVI over the Tibetan Plateau in the last 21 years and its response to different driving factors were investigated by using the Sen slope method, Mann–Kendall mutation test, partial correlation analysis and geographical detector method. The results showed that (1) the vegetation coverage on the Qinghai-Tibet Plateau showed an increasing trend from 1999 to 2019, with increases in approximately 67.00% of the plateau area. (2) The spatial differences in vegetation coverage were large; notably, low-density vegetation areas decreased obviously, moderate-density vegetation areas accounted for approximately 50% of the total area, high-density vegetation areas were the least common, and the overall growth rate was significant. (3) The NDVI was positively correlated with temperature and precipitation, and a positive correlation was observed in more than 66% of the region. (4) The order of the influence of single driving factors on the NDVI was as follows: precipitation > soil type > altitude > temperature > gradient > slope > population density > GDP. (5) The effect of multiple factors was significantly higher than that of single driving factors, with a notable nonlinear influence. The interactions between meteorological factors, such as precipitation, and topographic factors, such as altitude, were important, with a q value over 0.79.

Predicting the tidal wave is essential not only to better understand hydrological cycle at the boundary between land and ocean but also to improve energy production in the coastal area. As affected by various factors such as astronomical, meteorological, and hydrological effects, predicting the tidal wave at the estuary remains uncertain. In this study, we present a novel method to improve short-term tidal wave predictions using a fixed-lag smoother based on sequential data assimilation (DA). The proposed method is implemented for the tidal wave predictions at the estuary of Nakdong River. As a result, the prediction accuracy was improved by 63.9% with DA and the calibration using the regression. Although the accuracy of DA diminished for increasing forecast lead times, the 1-hr lead forecast by DA had still 44.4% improvement over the open loop without DA. Plus, the optimal conditions for the fixed-lag smoother were analyzed in terms of the order of a smoothing function and the length of assimilation window and forecast lead time. It was suggested that the optimal DA configuration could be obtained with the 8th order polynomial as a smoothing function assimilated under 6-hr or longer past and future DA windows.

This paper numerically investigates a 3D mesh independency study of a straight blade horizontal axis tidal turbine modelled using Computational Fluid Dynamics (CFD). The solution was produced by employing two turbulence models, the standard k-ε model and Shear Stress Transport (SST) in ANSYS CFX. Three parameters were investigated: mesh resolution, turbulence model, and power coefficient in the initial CFD, analysis. It was found that the mesh resolution and the turbulence model affect the power coefficient results. The power coefficients obtained from the standard k-ε model are 15% to 20% lower than the accuracy of the SST model. It can also be demonstrated that the torque coefficient increases with the increasing Tip Speed Ratio (TSR), but drops drastically after TSR = 5 and k-ε model failing to capture the non-linearity in the torque coefficient with the increasing TSR.

Space-time evolution is briefly explained by using the 3-dimensional quantized space model (TQSM) based on the 4-dimensional (4-D) Euclidean space. The energy (mass), charges and absolute time are newly defined based on the 4-D Euclidean space. The photons and gravitons are understood as the 2-D space fluctuations along the space axes and 1-D time fluctuations along the time axis, respectively. This indicates that the electromagnetic (EM) and gravitational (G) waves can be unified into the so called gravityelectromagnetic (GEM) wave which has both space and time fluctuations. The photon with zero force fields is the 2EM wave because an EM wave corresponds to a charged fermion. The dark matter bosons, weak force bosons, strong force bosons are the 1-D time fluctuations which can be expressed by the G waves. This indicates that all five forces are unified by the GEM wave. It is called as the super unification theory in the present work. And the force carrying bosons and mesons are, for the first time, proposed as the possible candidates of the magnetic monopoles like the fermions and baryons are the electric monopoles. The signs of the magnetic charges quantized as q_m=cq are newly defined. The big bang is understood by the space-time evolution of the 4-D Euclidean space but not by the sudden 4-D Minkowski space-time creation. The big bang process created the matter universe with the positive energy and the partner anti-matter universe with the negative energy from the CPT symmetry.

The potency and challenges of sorghum development in tidal swamplands in Indonesia have yet to be well studied. Our research was the first to evaluate land suitability, economic performance, and strategies for developing sorghum in tidal swamplands in Central Kalimantan. The assessment methods for the potency and utilization of sorghum used the land suitability evaluation method, gross margin and profit analysis, break-even, and competitive analysis. As a tool for decision-making, we used SWOT followed by the quantitative strategic planning matrix (QSPM) analysis. The results showed that the potency of arable land suitable for sorghum development was 578,511 ha. Economically, sorghum farming can generate an IDR 12,894,000 per ha with a revenue-cost ratio of 1.72; the break-even price was IDR 2,447 per kg, around 42% lower than the current market price. Sorghum was also more competitive than cassava, sweet potato, and soybeans (Q values of 0.76, 0.58, and 0.61, respectively) and less competitive than maize (Q = 1.33). Based on the QSPM, there were five alternative strategies for developing sorghum in tidal swamplands, i.e., (1) Optimization of productivity, (2) Improving the quality of human resources of farmers, (3) Facilitation of partnership cooperation, (4) Application of site-specific technology, and (5) Optimization of waste utilization. Those strategies show the potential expansion of sorghum planting in the tidal swamplands and the economic value enhancement for the community.

The present paper deals with the stochastic modeling of bio-colonization for the computation of stochastic hydrodynamic loading on jacket-type offshore structures. It relies on a multidisciplinary study gathering biological and physical research fields that accounts of uncertainties at all the levels. Indeed, bio-colonization of offshore structures is a complex phenomenon with two major but distinct domains (i) marine biology whose processes are modeled with biomathematics methods and (ii) hydrodynamic processes. This paper aims to connect these two domains. It proposes a stochastic model for the marine organism’s growth and then continues with transfers for assessment of drag coefficient and forces probability density functions that accounts for marine growth evolution. A case study relies on the characteristics (growth and shape) of the blue mussel (Mytilus edulis) in northeastern Atlantic.

Nanopores with irregularities are promising tools for distinguishing nano-size objects by their shape, but the forces on the object that critically influence its axial and rotational movement are unclear. The physics of the situation was described using the Poisson-Nernst-Planck and Navier-Stokes equations. With uniformly charged object the axial Coulomb and dielectric pressure (which opposes it and is surprisingly important), control the object's axial movement and rotation. Even without external pressure the hydrodynamic pressure is significant (negative at its upper and positive at its lower surface), but its total value is almost zero. If the object is charged only on the upper surface the axial upper Coulomb pressure is near zero close to the center, but negative near its end (the pressure is zero at the lower surface). The total axial dielectric pressure, which is largely dominated by the pressure at the upper surface, is positive along the length of the object becoming pronounced near its end. The axial hydrodynamic pressure is negative and significant at the upper surface (zero at the lower surface), diminishes in value near the object's end, critically influencing its axial movement, which becomes much faster. At its end the axial dielectric pressure prevails, and controls its rotation.

Tidal swamp rice has long been cultivated by the local people of the South Kalimantan, Indonesia. This germplasm possess some important traits for adapted to a wide range of abiotic and biotic stresses. In this study, a total of sixteen cultivars of this germplasm, consisting of fifteen of the South Kalimantan Province and one of Sumatera Island, Indonesia (an outgroup) were analyzed, phylogenetically based on the chloroplast trnL-F and nuclear intergenic spacer region (IGS). The results showed that this germplasm has a relatively more extraordinary genetic diversity than other local rice germplasm. In a nucleotide level, this germplasm showed a genetic diversity of 0.61 for nuclear IGS and 0.58 for trnL-F. The phylogenetic reconstruction also exhibited that this germplasm has the unique illustration of phylogenetic trees, particularly for the combined sequence datasets. Thus, the results of our study would provide useful information for further understanding of evolutionary relationships of this germplasm and facilitate the efficient utilization of valuable genes for genetic improvement, particularly in the tidal swamp areas.

The material flow dynamic and velocity distribution on the melted domain surface play a crucial role on the joint quality and formation of welding defects. In this study, authors investigated the effects of the low and high currents of plasma arc welding on the material flow and thermodynamics of molten pool and its relationship to the welding defects. The high-speed video camera (HSVC) was used to observe the convection of the melted domain and welded-joint appearance. Furthermore, to consider the Marangoni force activation, the temperature on the melted domain was measured by a thermal HSVC. The results revealed that the velocity distribution on the weld surface was higher than that inside the molten weld pool due to the difference of the massive density between the air and the steel. Moreover, in the case of low welding current (80A) the convection speed of molten was faster than that of the high welding current case (160A) owing to the difference of main driving forces direction and strength, which leading to undercut and humping defects on the weld surface and excessive convex (burn-through) defect at the bottom weld side, respectively. The medium welding current (120A) had two convection patterns with the main flow in backward direction, which resulted in better welding quality without defect. The interaction between the shear force and Marangoni force played a solid state on the convection and heat transportation processes in the plasma arc welding process.

After a local pollution control plant significantly reduced phosphorus loading into a phytoplankton-dominated tributary of the Potomac River in the early 1980’s, water quality and biological communities were monitored bi-weekly from April-September. After a 10-year time-lag, submerged aquatic vegetation (SAV), once abundant in this freshwater tidal embayment, returned to the area in 1993. After additional reductions in nitrogen load starting in 2000, the system completely switched to a SAV-dominated state in 2005. Fish abundance didn’t change during these distinct phase changes, but the fish community structure did. Increases in SAV provided refuge and additional spawning substrate for species with adhesive eggs such as Banded Killifish (Fundulus diaphanus), which is now the most abundant species in the embayment. Other changes seen were a decrease in the relative contribution of open water dwelling species such as White Perch (Morone americana), and an increase of visual predators such as Largemouth Bass (Micropterus salmoides). The 30-year record of data from this Potomac River tributary has revealed many important long-term trends that validate the effectiveness of initiatives to improve water treatment, and will aid in the continued management of the watershed and point source inputs.

Supervised machine learning (SML) is a powerful method for predicting a small number of well-defined output groups (e.g., potential buyers of a certain product) by taking as input a large number of known well-defined measurements (e.g., past purchases, income, ethnicity, gender, credit record, age, favorite color, favorite chewing gum). SML is predicated upon the existence of a training dataset in which the correspondence between the input and output is known to be true. SML has had enormous success in the world of commerce, and this success may have prompted a few scientists to employ it in the study of molecular and genome evolution. Here, we list the properties of SML that make it an unsuitable tool in certain evolutionary studies. In particular, we argue that SML cannot be used in an evolutionary exploratory context for the simple reason that training datasets that are known to be a priori true do not exist. As a case study, we use an SML study in which it was concluded that most human genomes evolve by positive selection through soft selective sweeps (Schrider and Kern 2017). We show that in the absence of legitimate training datasets, Schrider and Kern (2017) used (1) simulations that employ many manipulatable variables and (2) a system of cherry-picking data that would put to shame most modern evangelical exegeses of the Bible. These two factors, in addition to the lack of methodological detail and negative controls, lead us to conclude that all evolutionary inferences derived from so-called SML algorithms (e.g., S-HIC) should be taken with a huge shovel of salt.

Tidal stream energy is a renewable energy resource that might be developed to offset carbon emissions. A tidal energy demonstration (TED) area has been designated in Minas Passage, Bay of Fundy, for testing and installing marine hydrokinetic (MHK) turbines. Regulations require quantification of the potential for MHK turbine installations to harm local populations of marine animals. Here we use acoustic telemetry to quantify probability that post smolt Inner Bay of Fundy salmon encounter a turbine installation at the TED area. Previous work has quantified detection efficiency of Innovasea HR acoustic tags as a function of current speed and range from a moored HR2 receiver and also demonstrated that drifters carrying HR tags will be effectively detected when the drifter track crosses the array of HR2 receivers in Minas Passage. Salmon smolts were tagged and released in Gaspereau and Stewiacke Rivers, Nova Scotia, in order that the HR2 receiver array could monitor seaward migration of the post smolts through Minas Passage and particularly through the TED area. Presently we demonstrate methods by which tag signals detected by the HR2 array can be used to estimate the expected number of times that a post smolt would encounter a single near-surface MHK turbine installation during its seaward migration.

The mangrove plant Acanthus ilicifolius and its relative, A. mollis, have been previously proved to possess diverse pharmacological effects. Therefore, evaluating the differentially expressed proteins of these species under tidal flooding stress is essential to fully exploit and benefit from their medicinal values. The roots of A. ilicifolius and A. mollis were exposed to 6 h of flooding stress per day for 10 days. The dry weight, hydrogen peroxide (H2O2) content, anatomical characteristics, carbon and energy levels, and two-dimensional electrophoresis coupled with MALDI-TOF/TOF MS technology were used to reveal the divergent flooding resistant strategies. A. ilicifolius performed better under tidal flooding stress, which was reflected in the integrity of the morphological structure, more efficient use of carbon and energy, and a higher percentage of up-regulated proteins associated with carbon and energy metabolism. A. mollis could not survive in flooding conditions for a long time, as revealed by incomplete cell structures of the roots, less efficient use of carbon and energy, and a higher percentage of down-regulated proteins associated with carbon and energy metabolism. Energy provision and flux balance played a role in the flooding tolerance of A. ilicifolius and A. mollis.

Impact force and maximum velocity are important indicators of kick efficiency in fighting activities. Therefore, this systematic review compared the front kick (FK) and roundhouse kick (RK), including maximal and impact force, maximum velocity, maximum angular velocity, and execution time, at different target types and experience levels. The Web of Science, SportDiscus, and PubMed were systematically searched from January 1982 to May 2022, according to PRISMA guidelines. The normalized kicking values were compared using one-way ANOVA. Eighteen articles, including FK with a pooled sample of 113 elite men, 109 sub-elite men, and 46 novices, and 25 articles, including RK with a sample of 238 elite men, 143 sub-elite men, and 27 novice men, fulfilled the inclusion criteria. The primary findings were that the impact forces of FK were higher than RK for the novice, sub-elite, and elite groups by 47% (p<0.01), 92% (p<0.01), and 120% (p<0.01), respectively. Moreover, the maximum foot velocity of RK was faster than FK for the sub-elite and elite groups by 44% (p<0.01) and 48% (p<0.01), respectively. The Elite group had 65% (p<0.01) higher knee extension angular velocity within RK than FK, and 138% (p<0.01) higher hip extension angular velocity within FK than RK.

In China, "new quality productive forces" have become an important focus for high-quality development; accelerating this development is an important task for the Chinese government in 2024. Such development relies on the traction of the digital economy. In view of this, developing “new quality productive forces” driven by the Chinese digital economy requires focusing on blocking points, such as the insufficient vitality of data, inadequate algorithmic regulation, the uneven distribution of computing power resources and the immature market environment. In order to dredge these blocking points, it is necessary to establish basic rules on data, strengthening algorithm supervision, building a national integrated computing power network, and optimizing the market environment.

Temperature dependent entropic force acting between the straight direct current I and the linear system (string with length of L) of N elementary non-interacting magnets/spins μ is reported. The system of elementary magnets is supposed to be in the thermal equilibrium with the infinite thermal bath T. The entropic force at large distance from the current is given by Fmagnen=Nμ02μ2I24π2kBTr3 , where r is the distance between the edge of the string and the current I, and kB is the Boltzmann constant; (r≫L is adopted). The entropic magnetic force is the repulsion force. The entropic magnetic force scales as Fmagnen~1T , which is unusual for entropic forces. The effect of “entropic pressure” is predicted for the situation when the source of the magnetic field is embedded into the continuous media, comprising elementary magnets/spins.

It is shown that the four fundamental physical forces, i.e. weak interaction, strong interaction, electromagnetism and gravity, all have their origin in the quark as the single true elementary particle.This requires conceiving the quark as a Dirac particle in a pseudo-tachyon mode, which possesses two real dipole moments: the common one associated with its angular momentum and a second one that is polarisable in a scalar field. This Dirac particle carries a regular charge magnetic monopole without Dirac’s string, theorized by Comay. The boson carrier of its field of energy is the gluon showing an exponential decay of its spatial range because of the influence of an omni-present energetic background field, known as the Higgs field, in this article interpreted as the Lambda in Einstein’s Field Equation.

Computational fluid dynamics is used to study the impact of the support structure of a tidal turbine on performance and the downstream wake characteristics. A high-fidelity computational model of a dual rotor, contra-rotating tidal turbine in a large channel domain is presented, with turbulence modelled using large eddy simulation. Actuator lines represent the turbine blades, permitting the analysis of transient flow features and turbine diagnostics. The following four cases are considered: the flow in an unexploited, empty channel; flow in a channel containing the rotors; flow in a channel containing the support structure; and flow in a channel with both rotors and support structure. The results indicate that the support structure contributes significantly to the behaviour of the turbine and to turbulence levels downstream, even when the rotors are upstream. This implies that inclusion of the turbine structure, or some parametrisation thereof, is a prerequisite for the realistic prediction of turbine performance and reliability, particularly for array layouts where wake effects become significant.

In the context of the era of New Quality Productive Forces, technological innovation has become the core force to promote the development of social productivity, which is closely linked with vocational education, and together create a strong demand for high-quality technical and skilled personnel. In order to meet this demand, vocational education must synchronize with the development of the New Quality Productive Forces and form a mechanism of mutual promotion. The key to promoting the high-quality development of vocational education lies in taking technological innovation as the guide, and comprehensively improving the quality of education through measures such as innovating the education model, deepening the integration of industry and education, and enhancing the adaptability of specialties. To this end, vocational education should actively build bridges for the integration of industry and education, enhance the flexibility and adaptability of the education system, innovate the mechanism of talent cultivation, and establish a comprehensive quality assurance system. Together, these efforts will promote vocational education to enter a new stage of high-quality development and provide a solid talent guarantee for the sustainable development of the social economy.

Desmoglein 3 (Dsg3) plays a crucial role in cell-cell adhesion and tissue integrity. Increasing evidence suggests that Dsg3 acts as a regulator of cellular mechanotransduction, but little is known about its direct role in mechanical force transmission. The present study investigated the impact of cyclic strain and substrate stiffness on Dsg3 expression and its role in mechanotransduction in keratinocytes. A direct comparison was made with E-cadherin, a well-characterized mechanosensor. Exposure of oral and skin keratinocytes to equiaxial cyclic strain promoted changes in expression and localization of junction assembly proteins. Knockdown of Dsg3 by siRNA blocked strain-induced junctional remodeling of E-cadherin and Myosin IIa. Importantly, the study demonstrated that Dsg3 regulates the expression and localization of YAP, a mechanosensor and an effector of the Hippo pathway. Furthermore, we showed that Dsg3 forms a complex with phospho-YAP and sequestered it to the plasma membrane, while Dsg3 depletion had an impact on both YAP and phospho-YAP in their response to mechanical forces, increasing the sensitivity of keratinocytes to strain- or substrate rigidity-induced nuclear relocation of YAP and phospho-YAP. PKP1 seemed to be crucial in recruiting the complex containing Dsg3/phospho-YAP to the cell surface since its silencing affected both Dsg3 junctional assembly with concomitant loss of phospho-YAP at cell periphery. Finally, we demonstrated that this Dsg3/YAP pathway has an influence on the expression of YAP1 target genes and cell proliferation. Together, these findings provide evidence of a novel role for Dsg3 in keratinocyte mechanotransduction.

The sustainable management of public hospitals is usually threatened by long-period operating deficit, especially during the pandemic of COVID-19. This study aims at quantitatively decomposing the historical changes in the annual operating costs of public hospitals in Japan to identify the main driving forces responsible for a worsening imbalance between operating costs and income over the past two decades. A dataset of the annual operating costs of public hospitals in Japan is compiled, in which influencing factors are redefined to make the data amenable to the application of a decomposition method referred to as the Logarithmic Mean Divisia Index (LMDI). Using the LMDI method, the contribution of each influencing factor to the changes in public hospital operating costs was quantitatively determined. The results indicate an overall positive effect arising out of the national reform of public hospitals that aimed to reduce the operating costs of these institutions, but the rapid increase in the prices of medicines in recent years made a major contribution to the increasing operating costs. The pandemic reveals a damage on public hospitals’ financial balance but the city-wide lockdown offset part of the increased medical expense. Both long-term and short-term pricing policies are required for the sustainable management of public hospitals.

Abstract: Changes in forest landscapes have been connected with human activity for centuries, which can be considered as one of the main driving forces of change in the global perspective. The spatial distribution of forests changes along with the geopolitical situation, demographic changes, intensification of agriculture, urbanization or changes in the land use policy. However, due to the limited availability of historical data, the driving forces of changes in forest landscapes are most often considered in relation to recent decades, without taking into account long-term analyzes. The aim of this paper is to determine the impact of natural and socio-economic factors on changes in forest landscapes within the protected area – Ślęża Landscape Park and its buffer zone in the aspect of long-term analyzes covering the period of 140 years (1883-2013). The comparison of historical and current maps, demographic data on 4 different periods as well as natural and location factors by using the ArcGIS software allowed analyzing selected driving forces of forest landscape transformations. We took into account natural factors like altitude, slope, exposure of the hillside and socio-economic drivers like population changes, distances to centers of municipalities, main roads and built-up areas.

Land use/cover (LULC) change is one of the most important environmental phenomena that have affected the earths’ systems and its ecosystem services. Hence, this study was conducted with the main objective of assessing LULC change, its drivers andimpactson ecosystem services in Jimma Rare district for the year 1974–2019. In order to understand the spatial and temporal changes of LULC and its drivers four satellite images for the year1974, 1991, 2005 and 2019 were obtained and respondent interviews, focus group discussions (FGD) and field observations were employed. Moreover, the ecosystem service value coefficients developed at a global level were used to assess the impacts of LULC on ecosystem service provision of the study area. The results of the study revealed that grass land and forest land decreased from 4518.87ha (13.09%) to 902.42ha (2.61%) and 3287.79ha (9.52%) to 2506.63ha (7.26%) from 1974-2019 respectively. Similarly, wetland declined from1182.08ha (3.42%) to 562.37ha (1.63%) in the stated period.The greatest expansion of cultivated land and settlement area occurred during the year 1974-1991. Agricultural expansion, deforestation, overgrazing and expansion of rural and urban settlement were among the major proximate causes. Likewise, the major underlying drivers of LULC dynamics include population increase, the presence of weak policy and institutions, poverty and lack of awareness were identified by respondents and focus group discussants. The total natural capital value reduced from 662.75 (million $/ha/yr) to 577.03 (million $/ha/yr) in the study period indicating the impacts of LULC on ecosystem services. From this study, it is possible to conclude that Jimma Rare District has experienced a significant change in LULC and ecosystem service values over the past 45 years. Hence, appropriate policy packages of land use are required to curb the negative impacts of such changes in the study district in the provision of the required services for sustainable development.

Battlefield miracle stories are not rare. This paper suggests a typology of battlefield miracles. From this perspective it asks what sort of miracles can we expect to see in battle and when can we expect to see them? After presenting the main points of discussion regarding miracles, it proposes a range of categories for military miracles (miracles as acts that violate nature versus miracles as everyday acts; those involving the divine versus occurrences not requiring the presence of a heavenly emissary; acts of benevolence versus acts with no such intent; having a clear purpose versus acts where there is disagreement regarding interpretation). After discussing these categories, the articles uses Operation Cast Lead (December 2008–January 2009) as a case study to test the typology suggested above. Since this field is underdeveloped, this paper sets out to initiate a conversation on battlefield miracles, with hope that future studies will build upon it.

In two previous papers, we calculated the dielectrophoresis (DEP) force and corresponding trajectories of high- and low-conductance 200-µm 2D spheres in a square 1x1mm chamber with plane-versus-pointed, plane-versus-plane and pointed-versus-pointed electrode configurations by applying the law of maximum entropy production (LMEP) to the system. Here, we complete these considerations for configurations with four-pointed electrodes centered on the chamber edges. The four electrodes were operated in either object-shift mode (two adjacent electrodes opposite the other two adjacent electrodes), DEP mode (one electrode versus the other three electrodes), or field-cage mode (two electrodes on opposite edges versus the two electrodes on the other two opposite edges). As in previous work, we have assumed DC properties for the object and the external media for simplicity. Nevertheless, every possible polarization ratio of the two media can be modeled this way. The trajectories of the spherical centers and the corresponding DEP forces were calculated from the gradients of the system’s total energy dissipation, described by numerically-derived conductance fields. In each of the three drive modes, very high attractive and repulsive forces were found in front of pointed electrodes for the high and low-conductance spheres, respectively. The conductance fields predict bifurcation points, watersheds, and trajectories with multiple endpoints. The high and low-conductance spheres usually follow similar trajectories, albeit with reversed orientations. In DEP drive mode, the four-point electrode chamber provides a similar area for DEP measurements as the classical plane-versus-pointed electrode chamber.

Semidiurnal tidal currents can exceed 5 ms−1 in Minas Passage, Bay of Fundy, where a tidal energy demonstration area has been designated to generate electricity using marine hydrokinetic turbines. The risk of harmful fish-turbine interaction cannot be dismissed for either migratory or local fish populations. Individuals belonging to several fish populations have been acoustically-tagged and monitored by using acoustic receivers moored within Minas Passage. Detection efficiency ρ is required as the first step to estimate probability of fish-turbine encounter. Moored Innovasea HR2 receivers and high residency (HR) tags were used to obtain detection efficiency ρ as a function of range and current speed, for near-seafloor signal paths within the tidal energy development area. Strong tidal currents moved moorings so HR tag signals, and their reflections from the sea surface, were used to measure ranges from tags to receivers. HR2 self-signals that reflected off the sea surface showed which moorings were displaced to lower and higher levels on the seafloor. Some of the range testing paths had anomalously low ρ which might be attributed to variable bathymetry blocking the line of sight signal path. Clear and blocked signal paths accord with mooring levels. Application of ρ is demonstrated for calculation of abundance, effective detection range, and detection-positive intervals. High residency signals were better detected than pulse position modulation (PPM) signals. Providing the presently obtained ρ applies to tagged fish that swim higher in the water column, there is a reasonable prospect that probability of fish-turbine encounter can be estimated by monitoring fish that carry HR tags.

Under the wave of technological advancement and industrial upgrading, new productivity is deeply influencing the field of vocational education and promoting fundamental changes in teachers' roles. Modern teachers must not only keep pace with technological development but also master innovative teaching modes and guide students to form correct values. They are gradually evolving from mere knowledge transmitters to guides for learning, stimulators of interest, explorers of in-depth research, and promoters of comprehensive growth. Through interdisciplinary knowledge structures and innovative abilities, combined with advanced tools such as information technology and artificial intelligence, teachers innovate teaching methods to meet students' diverse learning needs and focus on cultivating students' professional skills, comprehensive qualities, and innovative spirits. This multi-dimensional reshaping of roles is not only an inevitable choice for the development of vocational education but also provides important insights for educational reform.

We calculate the hydrodynamic forces exerted on an oscillating circular cylinder when it moves translationally perpendicular to its axis in the infinitely deep water covered by compressed ice. The cylinder can oscillate both horizontally and vertically. In the linear approximation, we find a solution for the steady wave motion generated by the cylinder within the hydrodynamic set of equations for the incompressible ideal fluid. We show that depending on the rate of ice compression, the normal and anomalous dispersion can occur in the system. In the latter case, the group velocity can be opposite to the phase velocity in a certain range of wavenumbers. We investigate the dependences of the hydrodynamic loads (added mass, damping coefficients, wave resistance, and lift force) exerting on the cylinder on the translational velocity and frequency of oscillation. It is shown that there is a possibility of the appearance of negative values for the damping coefficients at the relatively big cylinder velocity; then the wave resistance decreases with increasing of cylinder velocity. The theoretical results are underpinned by the numerical calculations for the real parameters of ice and cylinder motion.

The Hwangdo tidal flat is an intertidal landform located in Cheonsu Bay, Taean-gun, Chungcheongnam-do, on the west coast of Korea. The topographical characteristics of the semi-enclosed bay on the eastern side of the study area include waterways, sandbars, small islands, and tidal flats. In this study, data were acquired from tide gauges installed on the Hwangdo Bridge, and the height of the ellipsoid was measured using a real-time kinematics global positioning system (RTK-GPS). Digital elevation model (DEM) using Matrice 300 drone data were also acquired after processing. The geochemical sediment characteristics in the study area were analyzed, together with tidal-flat exposure-time characteristics based on environmental factors. Sediment data (n = 107) collected from October 25 to 28, 2022 (Korean local time) were used to classify sediment particles according to Folk and Ward (1957). Sedimentary facies ranged from coarse sand (sand:mud ratio = 9:1) to sandy silt (sZ) followed by muddy sand (mS) and slightly gravelly sandy mud ((g)sM). Total organic carbon (TOC) in the surface sediments were also characterized based on a particle-size analysis. The mean change in tidal height measured at Hwangdo Bridge during the sampling period was ~7.53 m (minimum: –3.86 m, maximum: +3.67 m). Based on the Boryeong's sea level measurement tide data in 2022, the tidal area in the drone images ranged from 6.362 m² (0.006 km²) at DEM +4.0 to 4,841,078 m² (4.841 km²) at DEM –4.0 m, indicating an increase in the tidal-flat area according to the tidal level of up to ~800-fold. The daily average exposure time was 9.0 h (minimum: 1.5 h, maximum: 17.9 h). Based on the results of multivariate analysis using exposure times and a geochemical dataset, four groups were identified: upper, middle, and lower intertidal zones and regions with a relatively high organic-matter concentration. A determination of the main characteristics of the Hwangdo tidal flat according to their spatial distribution showed that, among various environmental factors, changes in the sand or clay sediment composition were determined by community factors. The results of this study demonstrate the four statistically processed groups of marine environmental characteristics in the Hwangdo tidal flats. Changes in sedimentary patterns, rather than in the exposure time, accounted for the differences in the sediment compositions of the upper, middle, and lower stations, a response that is expected to continue.

The Mont-Saint-Michel is known worldwide for its unique combination of the natural site and the Medieval abbey at the top of the rocky islet. But the Mont is also located within an estuarine complex, which is considerably silting up. For two decades, large-scale works were planned to prevent the Mont from being surrounded by the expanding salt meadows. The construction of a new dam over the Couesnon River, the digging of two new channels, and the destruction of the causeway were the main operations carried out between 2007 and 2015. The remote sensing approach is fully suitable for evaluating the real impact of the engineering project in both time and space, particularly the expected large-scale hydrosedimentary effects, for reestablishing the maritime landscape around the Mont. Sentinel-2 satellite data have been used for the period from 2015 to 2023. Aster data were used for the previous period covering 2000 to 2017. Aerial photographs and an ALOS scene have been also used. The remote sensing approach is based on time-series images. It allows identifying local or regional consequences and temporary or permanent effects. The migration of the different channels (especially for the new west and east Couesnon river courses) and the erosion-progradation balance of the vegetation through space and time are the main features to study. Between 2007 and 2023, the erosion of the salt meadows is significant to the south-west of the Mont (− 150 ha) but more limited to the south-east (− 65 ha). The erosion effect is limited to the immediate environment because the vegetation fringe of the uppermost tidal flat along the main dike is slightly increasing (+ 35 ha) to the west and to the east (+ 40 ha). During the same period, the sedimentation considerably increased to the north-east of the Bay, between the Bec d’Andaine, the Grouin du Sud and Tombelaine islet, which seems now facing the same silting-up problem. At this stage, the remote-sensing survey indicates mixed results for the engineering project.

Background: The major histocompatibility complex (MHC) plays a key role in the adaptive immune response to pathogens due to its extraordinary polymorphism. However, the spatial patterns of MHC variation in the striped hamster remain unclear, particularly regarding the relative contribution of balancing selection in shaping MHC population and diversity compared to neutral forces. Methods: In this study, we investigated the immunogenic variation of the striped hamster in four wild populations in Inner Mongolia, which experience heterogeneous parasitic stress. Our goal was to identify local adaptation by comparing the genetic structure at MHC with that at seven microsatellite loci, taking into account neutral processes. Results: We observed significant variation in parasite pressure among sites, with parasite burden showing a correlation with temperature and precipitation. Molecular analysis revealed a similar co-structure between MHC and microsatellite loci. We observed lower genetic differentiation at MHC loci compared to microsatellite loci, and no correlation was found between the two. Conclusions: Overall, these results suggest a complex interplay between neutral evolutionary forces and balancing selection in shaping the spatial patterns of MHC variation. Local adaptation was not detected at a small scale but may be applicable at a larger scale.

The general-purpose Compact Muon Solenoid (CMS) detector at the Large Hadron Collider (LHC) at CERN includes the hadronic calorimeter to register the energies of the charged and neutral hadrons produced in the proton-proton collisions at the LHC at a center of mass energy 13.6 TeV. The calorimeter is located inside the superconducting solenoid of 6 m in diameter and 12.5 m in length creating the central magnetic flux density of 3.8 T. For operating optimally in the high pileup and high radiation environment of the High Luminosity LHC, the existing CMS endcap calorimeters will be replaced with a new high granularity calorimeter (HGCal) comprising of an electromagnetic and a hadronic section in each of the two endcaps. The hadronic section of the HGCAL will include 44 stainless steel absorber plates with a relative permeability value well below 1.05. The volume occupied by 22 plates in each endcap is about 21 m3. The calculation of the axial electromagnetic forces on the absorber plates is a crucial element in designing the mechanical construction of the device. With a three-dimensional computer model of the CMS magnet, the axial forces on each absorber plate are calculated and the dependence of forces on the central magnetic flux density value is presented. The method of calculation and the obtained results are discussed.

Rotational jumps are crucial techniques in sports competitions. Estimating ground reaction forces (GRFs), one of the components constituting jumps, through a biomechanical model-based approach enables analysis even in environments where force plates or machine learning training data cannot be utilized. In this study, rotational jump movements involving twists on land were measured using inertial measurement units (IMUs) and estimated GRFs and body loads using a 3D forward dynamics model. Our estimation method, based on forward dynamics and optimization calculations, generated and optimized body movements using cost functions defined by motion measurements and internal body loads. To reduce the influence of the dynamic acceleration in the optimization calculation, the 3D orientation using sensor fusion composed of acceleration and angular velocity data obtained from IMUs and an extended Kalman filter was estimated. As a result, by generating movements based on the cost function, it was possible to calculate biomechanically valid GRFs while following the measured movements even if not all joints are covered by IMUs. This estimation method allows for 3D motion analysis independent of measurement conditions or training data.

Predicting ground reaction forces (GRFs) and ground reaction moments (GRMs) through a biomechanical model-based approach offers advantages for biomechanical analysis, particularly in situations where the application of a statistical model is limited by insufficient training data. However, the current prediction method is unsuitable for clinical applications due to its long computational time. The present study developed a new optical motion capture (OMC)-based method to predict GRFs, GRMs, and joint torques. The proposed approach performed the estimation process by distributing external forces, as determined by the equation of motion, between the left and right feet based on foot deformations, thereby predicting the GRFs and GRMs without relying on machine learning or optimization techniques. We investigated the prediction accuracy during walking by comparing a conventional analysis using a force plate with the OMC results. The comparison revealed excellent or strong correlations between the prediction and measurement for all GRFs, GRMs, and lower limb joint torques. The proposed method, which provides practical estimation with low computational cost, facilitates efficient biomechanical analysis and rapid feedback of analysis results, thereby increasing its applicability for kinetics estimation in clinical settings.

In this paper, the stability control of the inverted pendulum on a cart with a disturbance forces has been done using observer based and full state feedback H2 controllers. The Lagrangian equation has been used to model the system equation of motions and linearized the system to the unstable upward position. Comparison of the system stability has been simulated by comparing the proposed controllers using Matlab/Scripts and a promising results has been analyzed successfully.

The delayed effects of radiation alone and combined with skin injury on the kidney are poorly understood. We aimed to unravel and compare the inflammatory, oxidative stress, and survival signaling pathways in the kidney cortex before mice manifested renal dysfunction after these two injuries. Mice were analyzed 30 days post irradiation (9.5 Gy for radiation alone, 9.0 Gy for radiation combined with a skin wound). Radiation alone did not significantly alter BUN, NGAL, or KIM-1 protein levels, indicating preserved kidney function. However, the combined injury had increased KIM-1 protein levels, indicating a nuanced effect on renal health. Radiation and combined injury activated distinct inflammatory pathways. Radiation increased STAT3-Y705 phosphorylation, while combined injury boosted STAT1-Y701 phosphorylation. Additionally, radiation increased mRNA abundance of IFNγR1, IFNγR2, heparanase and IL-10, while combined injury tended to increase heparanase mRNA levels and reduced IL-4 mRNA levels. Both injuries increased the abundance of HO-1 protein, indicating oxidative stress, but radiation alone also reduced MnSOD and catalase proteins. Both injuries promoted AKT1-S473 phosphorylation and diminished p53 protein levels, suggesting inhibition of apoptosis. In summary, despite the distinct activation of inflammatory and oxidative stress pathways, both radiation alone and combined injury activated protective mechanisms such as HO-1 and AKT1, offering insights into molecular events before manifesting renal dysfunction.

While many in-steam tidal energy resource studies have been carried out globally, very few studies have assessed the effect of seabed changes on tidal energy resources. For coastal regions in particular, where the seabed is generally more mobile than in deep waters, bathymetric evolution could have a significant effect on tidal energy production. Here two high-resolution models, one purely hydrodynamic and one morphodynamic, are used to analyse the potential effect of natural morphodynamic evolution on tidal energy resources at two macro-tidal sandy bays, Adaír Bay and San Jorge Bay, in the Upper Gulf of California, Mexico. The high-resolution models are validated using a low-resolution model and ADCP observations to assess the agreement between model predictions and observations of tides at three ADCP moorings within the domain of interest. The models’ skill is evaluated using several error statistics such as the mean relative error, the root mean square error (RMSE), and the correlation coefficient. It was found that the regions with the largest bed changes, and also the largest renewable energy resources, were near the shore. Moreover, the results indicated a good correlation between a) regions with the most significant depth changes, and b) the regions where the difference in annual energy production with and without depth change was largest. Finally, the morphodynamic model was run for two years, and the evolution of a zonal profile (in the west-east direction) off the coast at the southeastern corner of Adaír Bay was inspected. This profile evolved towards a featureless equilibrium profile, in good agreement with the morphological classification for macro-tidal sandy environments and with the model assumptions. But most importantly, this natural evolution would not be detrimental to tidal energy exploitation at the site.

The study proposes a theoretical method for evaluating the 'safety against derailment' indicator of a specialized train composition for the transportation of very long rails. A composition of nine wagons, suitable for the transportation of rails with a length of 120 m, is considered. For the remaining recommended rail lengths, the number of wagons is reduced or increased, the method being modified depending on the required configuration. In accordance with the requirements of EN 14363:2019, the composition is in a curve with a radius of R=150 m. The rails bend, some of them contact the vertical stanchions of the wagon and cause additional transverse forces, which are balanced in the rail track. This is a prerequisite for derailment of the vehicle. The goal of the study is to determine the additional transverse forces that arise because of the bent rails. The task is statically indeterminate, and considering the dimensions of the rails, its solution becomes seriously difficult. For the purposes of the study, the finite element method was used. Based on the displacements of the support points of the rails (caused by the geometry of the curve) the bending line of the elastic load is determined and the forces in the supports are calculated. A group of five rails is considered, with results multiplied proportionally for cases other than five. The resulting forces are considered when determining the derailment safety criterion defined by EN 14363:2019.

Our study utilized density functional theory (DFT) to explore a 2D MoP2 surface for hydrogen storage. Optimization determined a gravimetric capacity for pristine MoP2 of 5.72%, with an adsorption energy of ‒ 0.13 eV/molecule. For this surface with 12.5% Mo vacancies, we achieved 6.02% and ‒ 0.14 eV/molecule. We then introduced a novel criterion to test the attraction forces in hydrogen storage at a given temperature. This involved a first-principles molecular dynamics approach at various temperatures. To determine the number of molecules adsorbed on the surface at temperature T1, we conducted an FPMD calculation at T1, using the optimization as the initial system configuration. Subsequently, we performed a second FPMD calculation at a temperature T2 (with T2 ‹‹ T1), using the stable configuration of the first FPMD calculation as the initial configuration. If there were attraction forces on the molecules, they would move towards the surface. We identified as adsorbed molecules at temperature T1, only those that moved back toward the surface at temperature T2. The defective surface gave the best gravimetric capacity, ranging from 5.27% at 300 K to 6.02% at 77 K. The latter met the requirement from the US-DOE, indicating the potential practical application of our research in hydrogen storage.

The use of e-scooters and e-bicycles has been on the rise with an increased medical and financial burden. Our purpose was to identify risk factors for increased medical charges and recommend appropriate steps. We studied a retrospective cohort presenting to a level 1 urban trauma center from January 2018 through July 2019 due to micro-mobility platforms. The primary outcome for comparison was total billing cost and a regression analysis was performed to identify variables associated with higher cost. A total of 4073 patients were identified. The majority of which were males (67%), aged 20-30 years (41%). Helmet use reported in only 39.8%. Radiologic studies were performed more often in the e-bicycle group. Total billing charges amounted to 28.3 million New Israeli Shekels ($7.9 million). Average total cost was higher for e-bicycle injuries and in non-helmet users. Other factors associated with higher cost were age, and time of day 12:00-18:00. We recommend that urban cities invest in infrastructure in advance to micro-mobility introduction, regulate the use of e-platforms, designate resources for education on personal protective equipment and prepare medical centers in advance.

Women serve in diverse roles in the 21st century militaries of the world. They are no longer banned exclusively from combat. The presence of women on the battlefield has raised religious arguments and considerations. What role do religious arguments play in the discussion regarding women’s military service? The current paper examines this question in the context of the Israel Defense Forces (IDF): a conscription-based military that conscripts both men and women, religious and secular, for both combat and non-combat postings. Using the case of the pilot program in the IDF attempting to integrate women in the Israeli tank corps, the paper argues that religious considerations serve the same purpose as functional considerations and can be amplified or lessened, as needed.

The superficial quality of the strip is a very important issue in steel production; the profile, flat-ness, and geometry of strip are indicators of supreme quality. Considering the dimensions, the thickness is one of the most important variables in the production of strip. In the present study the elastic curve of Back Up Rolls (BUR) is analyzed, considering them as simply supported beams as well as the effect of rolls on the profile of the strip, specifically in the strip edge pro-ducing edge drop. The analysis is simulated with a model in 3D using a Finite Element Method (FEM) considering +0.039mm crown on Back Up Roll and +0.101mm crown on Work Roll (WR). The results showed that there is an instability zone of 76mm in the strip edge, this geometry is symmetrical in both ends of the strip, it was validated with the results of compact X-ray thick-ness gauge from a 4-high cold mill. This study not only provides a theoretical basis for the edge drop, but also provides the basis for the understanding of deformation on rolls used in rolling mill processes and their effect on the thickness, profile, shape, and dimensional quality of strips.

Background: Early diagnosis of postoperative complications is an urgent task, allowing timely prescribing of appropriate therapy and reducing the cost of patient treatment. Prognostic models based on various data could help in the early diagnosis of postoperative complications after cardiac surgery. Objectives: The purpose of the study was to determine whether an integrated approach based on clinical data along with metabolites and biomarkers had greater predictive value than the models built on less data. Methods: The study included patients (n=62) admitted for planned cardiac surgery (coronary artery bypass grafting with cardiopulmonary bypass), who were retrospectively divided into two groups depending on the presence (n=26) or absence (n=36) of postoperative complications of all types. Clinical and laboratory data on the first day after surgery were analyzed. Additionally, patients' blood samples were collected before and on the first day after surgery to determine biomarkers (interleukin-6, procalcitonin, NT-proBNP, high-sensitivity troponin T) and metabolites (8 aromatic and 2 dicarboxylic acids were detected using gas chromatography-mass spectrometry). Results: Patients before surgery, compared with healthy donors, differed in the concentration of metabolites (p &lt; 0.05), and had concentrations of a number of biomarkers exceeding the corresponding reference values. Multivariate PLS-DA models, predicting the presence or absence of postoperative complications, were built using clinical data (ROC-AUC=0.71), concentrations of metabolites and biomarkers (ROC-AUC=0.60), and the entire data set (ROC-AUC=0.75). For comparison we built univariate models using the EuroScore2 (ROC-AUC=0.59) and SOFA (ROC-AUC=0.76) scales; concentrations of lactate (ROC-AUC=0.71), the dynamic changes of 4-hydroxyphenyllactic acid (ROC-AUC=0.69), and the sum of three sepsis-associated metabolites (ROC-AUC=0.70). The proposed complex model using entire data set was comparable to the SOFA scale, which confirms the expediency of searching for new predictive models based on a variety of factors.

Milk serves as a crucial source of natural bioactive compounds essential for human nutrition and health. The gastrointestinal digestion of milk proteins releases various biologically active peptides that positively impact human health and enhance physiological performance. With the growing production of cheese, Greek yogurt, and other dairy products, the volume of unutilized acid whey is significantly increasing. Acid whey, containing almost all whey proteins and approximately one-quarter of casein, presents a valuable raw material for generating peptides with potential health benefits. These peptides exhibit properties such as antioxidant, antimicrobial, anti-inflammatory, anticarcinogenic, antihypertensive, antithrombotic, opioid, mineral-binding, and growth-stimulating activities, contributing to improved human immunity and the treatment of chronic diseases. Enzymatic hydrolysis of milk proteins has been developed as a method to produce these peptides, facilitating their use in food fortification. To incorporate whey into functional beverages, it undergoes fermentation by lactic acid bacteria with proteolytic activity. To specifically enrich these beverages with peptides exhibiting targeted bioactivities, it is essential to select lactic acid bacteria strains possessing the requisite protease profiles. Additionally, the sensory properties of the final product can be enhanced using starter cultures with diverse metabolic capabilities, even in the absence of added flavoring agents. Given the imperative to develop waste-free technologies and enhance the profitability of the dairy industry, there is a growing need to efficiently utilize and transform acid whey into a broad spectrum of valuable products and food additives. This approach is justified not only by the nutritional benefits of the bioactive components in whey but also by the commercial potential of safe and health-enhancing products.

The paper focuses on the application of a multilevel, integrative and territorial approach to the protection of cultural heritage through planning instruments in Serbia. It points out the problems of the sectoral approach and discusses international recommendations that can be integrated into the planning methodology. The case study is the area of Djerdap National Park, which has an already established international and national importance. The research suggests that the cultural heritage in the area, with the exception of the Roman limes, is still recognized at the level of individual localities. The study emphasizes the importance of aligning all levels of governance to safeguard the whole spatial entity rather than focusing solely on its particular areas. The interna-tional and national importance of the planning area contributes to the strengthening of awareness of heritage and its institutional protection. However, the vitality of the area, which is key to its sustainable development, comes from the local level. Planning documents contribute to the inte-gration of local values and local communities into development programs and projects.

In order to shorten the detection time and improve the average precision on embedded devices, A lightweight and high accuracy model is proposed for passion fruit in complex environments (backlight, occlusion, overlap, sunny, cloudy, rainy). Firstly, replacing the backbone network of YOLOv5 with a lightweight GhostNet model reduces the number of parameters and computation while improving detection speed. Secondly, a new feature branch is added to the GhostNet network, and the feature fusion layer in the neck network is reconstructed to effectively combine the lower-level and higher-level features, which not only improves the accuracy of the model but also maintains its lightweight. Finally, the knowledge distillation methods are used to transfer the knowledge from the more capable teacher model to the less capable student model, which significantly improving the detection accuracy. The improved model is denoted as G-YOLO-NK. The average accuracy of the G-YOLO-NK network is 96.00%, which is 1.00% higher than the original YOLOv5s model. Furthermore, the improved model size is 7.14MB, reduced to half of the original model, and the real-time detection frame rate is 11.25 FPS on the Jetson Nano. Compared to the state-of-the-art model, the proposed model outperforms them in terms of average precision and detection performance. The present work provides an effective model for real-time detection of passion fruits in complex orchard scenes, which can provide valuable technical support for the development of orchard picking robots and greatly improve the intelligence level of orchards.

The impact of interaction SS with MJO on rainfall along Java Island to East Nusa Tenggara has been studied using daily rainfall observation data from 2140 weather observation stations, which are also equipped with GSMaP, OLR, and ERA5 data. There were 61 SS events found, 17 during active MJO and 44 in inactive MJO. Rainfall increases more in the western study area when the active MJO and more in the eastern study area when the inactive MJO is due to SS. SS reduces rainfall in the Jakarta region, regardless of the activity or inactivity of the MJO. SS causes extreme rainfall to only occur in a small part of certain areas, so it tends to significantly reduce the possibility of extreme rainfall. In the southern part of the IMC, SS predominates over MJO in supporting increased water vapor transport. Large-scale synoptic circulations like the monsoon, SS, and MJO can interact with local land-sea wind circulation to produce spatiotemporal variability in rainfall on Java Island. Rainfall mostly increases in the afternoon and decreases in the morning when SS occurs, whether there is MJO or not. Convective instability analysis indicates that SS increases precipitation, most likely by lowering CIN and raising VIMFC.

The Simultaneous Localization And Mapping (SLAM) scanner is an easy and portable Light Detection And Ranging (LiDAR) data acquisition device. Its main output is a 3D point cloud covering the scanned scene. Regarding the importance of accuracy in the survey domain, this paper aims to assess the accuracy of two SLAM scanners: the NavVis VLX and the BLK2GO Scanner. This assessment is conducted for both outdoor and indoor environments. In this context, two types of reference data are used: the Total Station (TS) and the static scanner Z+F Imager 5016. To carry out the assessment, four comparisons are tested: cloud to cloud, cloud to mesh, mesh to mesh, and edge detection board assessment. However, the results of the assessments confirm that the accuracy of indoor SLAM scanner measurements (5 mm) is greater than that of outdoor ones (between 10 mm and 60 mm). Moreover, the comparison of cloud to cloud provides the best accuracy regarding direct accuracy measurement without manipulations. Finally, based on the high accuracy, scanning speed, flexibility, and the accuracy differences between tested cases, it is confirmed that SLAM scanners are effective tools for data acquisition.