BBC Russian

Preprint ARTICLE | doi:10.20944/preprints202407.1450.v1

Stat3 Inhibitors TTI-101 and SH5-07 Suppress Bladder Cancer Cell Survival In 3D Tumor Models

Surya Pratap Singh, Gopal Pathuri, Adam S Asch, Chinthalapally V. Rao, Venkateshwar Madka

Subject: Biology And Life Sciences, Life Sciences Keywords: Bladder cancer; STAT3 inhibitor; Apoptosis; Preclinical; 3D models

Online: 17 July 2024 (14:18:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201701.0033.v1

Establish and Apply a Safe and Convenient Pseudovirus-Based Assay to Detect Neutralizing Antibodies against Influenza A (H7N9) Virus

Li Zhang, Jing Lu, Jingxing Li, Rong Tang, Haiyan Peng, Fanyue Meng, Yuemei Hu

Subject: Biology And Life Sciences, Virology Keywords: H7N9 avian influenza; pseudovirus; neutralization assay; relative luminescence units (RLU)

Online: 6 January 2017 (10:21:52 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202408.0752.v1

Dietary Exposure to Pesticide and Veterinary Drugs Residues and Their Effects on Human Fertility and Embryo Development: A Global Overview

Ambra Colopi, Eugenia Guida, Silvia Cacciotti, Serena Fuda, Matteo Lampitto, Angelo Onorato, Alice Zucchi, Carmela Rita Balestrieri, Paola Grimaldi, Marco Barchi

Subject: Biology And Life Sciences, Life Sciences Keywords: food contaminants; transgenerational inheritance; organophosphates; glyphosate; antibiotics; active pharmaceutical ingredients

Online: 13 August 2024 (03:18:02 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0180.v1

The Distal Promoter of the B438L Gene of African Swine Fever Virus Is Responsible for the mRNA Transcription of the B438L and the Alternatively Spliced B169L

Hongwei Cao, Hao Deng, Yanjin Wang, Diqiu Liu, Lian-Feng Li, Meilin Li, Dingkun Peng, Jingwen Dai, Jiaqi Li, Hua-Ji Qiu, Su Li

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: African swine fever virus; B438L promoter; transcription initiation; B169L protein

Online: 3 May 2024 (09:46:58 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201608.0030.v2

Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China

Chao Wang, Shuang Li, Tao Li, Shanfa Yu, Junming Dai, Xiaoman Liu, Xiaojun Zhu, Yuqing Ji, Jin Wang

Subject: Social Sciences, Psychology Keywords: occupational stress; job burden-capital model; structural equation model; depression; well-being

Online: 4 August 2016 (12:47:57 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.2546.v1

Dynamics of Mammarenavirus Wenzhouense Acute Infection in the Rodent Rattus norvegicus

ShanShan Du, XueFei Deng, Xiaoxia Huang, TieZhu Liu, Aqian Li, Qin Wang, TingTing Tian, Chuan Li, ZhangQi Zheng, QiHan Lin, ZhuoWei Li, Shiwen Wang, Jiandong Li

Subject: Public Health And Healthcare, Other Keywords: Wenzhou virus; acute infection; virus shedding, transmission; rodents; arenavirus

Online: 31 July 2024 (15:21:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.1104.v1

MR protocol optimization for Hepatobiliary Phase Imaging with Gadoxetic Acid for 1.5T: Comparison Between Breath-Hold T1-weighted and High Resolution Navigated 3D T1-weighted sequences

Eliseo Picchi, Valentina Ferrazzoli, Valeria Liberto, Luca Toti, Raffaella Giocondo, Valerio Da Ros, Noemi Pucci, Silvia Minosse, Francesco Garaci, Francesca Di Giuliano

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Magnetic Resonance; Gadoxetic Acid; High Resolution Navigated 3D; Hepatocarcinoma

Online: 17 June 2024 (08:06:12 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1578.v1

TransPerineal Laser Ablation (TPLA) Treatment of Focal Low-Intermediate Risk Prostate Cancer

Guglielmo Manenti, Tommaso Perretta, Marco Nezzo, Federico Romeo Fraioli, Beatrice Carreri, Paola Elda Gigliotti, Andrea Micillo, Andrea Malizia, Daniele Di Giovanni, Colleen Patricia Ryan, Francesco Giuseppe Garaci

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: mpMRI; prostate cancer; TPLA; FLA; focal laser ablation; transperineal laser ablation

Online: 28 February 2024 (04:48:26 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.0600.v1

Characterization of Avian Influenza Viruses Detected in Kenyan Live Bird Markets and Wild Bird Habitats Reveal Genetically Diverse Subtypes and High Proportion of A(H9N2), 2018-2020

Peninah Munyua, Eric Osoro, Joyce Jones, George Njogu, Genyan Yang, Elizabeth Hunsperger, Christine Szablewski, Ruth Njoroge, Doris Marwanga, Harry Oyas, Ben Andagalu, Romona Ndanyi, Nancy Otieno, Vincent Obanda, Carolyne Nasimiyu, Obadiah Njagi, Juliana DaSilva, Yunho Jang, John R Barnes, Gideon Emukule, Clayton Onyango, Charles Davis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Africa; surveillance; poultry diseases; avian influenza; low pathogenic

Online: 8 August 2024 (08:53:37 CEST)

Show abstract| Download PDF| Share

Following the detection of highly pathogenic avian influenza (HPAI) virus in countries bordering Kenya to the west, we conducted surveillance among domestic and wild birds along the shores of Lake Victoria. In addition, between 2018 and 2020, we conducted surveillance among poultry and poultry workers in live bird markets and among wild migratory birds in various lakes that are resting sites during migration to assess introduction and circulation of avian influenza viruses in these populations. We tested 7,464 specimens (oropharyngeal and cloacal swabs) from poultry and 6,531 fresh fecal specimens from wild birds for influenza A viruses by real-time RT-PCR. Influenza was detected in 3.9% (n=292) of specimens collected from poultry and 0.2% (n=10) of fecal specimens from wild birds. On hemagglutinin subtyping, most of the influenza A positives from poultry (274/292, 93.8%) were H9. Of 34 H9 specimens randomly selected for further subtyping, all were H9N2. On phylogenetic analysis, these viruses were genetically similar to other H9 viruses detected in East Africa. Only two of the ten influenza A positive specimens from the wild bird fecal specimens were successfully subtyped; sequencing analysis of one specimen collected in 2018 was identified as low pathogenicity avian influenza H5N2 virus of the Eurasian lineage and the second specimen, collected in 2020, was subtyped as H11. A total of 18 OP/NS swabs from poultry workers with ARI (12%) were collected; none were positive for influenza A virus. We observed significant circulation of H9N2 influenza viruses in poultry in live bird markets in Kenya. During the same period, low pathogenic H5N2 virus was detected in a fecal specimen collected in a site hosting a variety of migratory and resident birds. Although HPAI H5N8 was not detected in this survey, these results highlight the potential for introduction and establishment of highly pathogenic avian influenza viruses in poultry populations and the associated risk of spillover to human populations.

Preprint ARTICLE | doi:10.20944/preprints202408.1291.v1

Development of Smallpox Antibody Testing and Surveillance Following Smallpox Vaccination in the Republic of Korea

Hwachul Shin, SangEun Lee, Myung-Min Choi, Hwajung Yi, Yoon-Seok Chung

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: smallpox; Vaccinia virus; smallpox vaccine; antibody titer; ELISA; bioterrorism

Online: 20 August 2024 (04:55:15 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1545.v1

Comprehensive Geophysical Exploration Technology for Sedimentary Exhalative Deposits: An Example from the Huaniushan Lead-Zinc-Silver Polymetallic Deposit in Gansu, China

Shunji Wang, Guanwen GU, Ye Wu, Xingguo Niu, Lin Zhu, Zhihe Xu, Haoyuan He, Yingjie Wang, Xinglong Lin, Lai Cao

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Sedimentary exhalative deposit; Huaniushan lead-zinc-silver polymetallic deposit; Gravity, magnetic and electric exploration; Three-dimensional inversion; Three-dimensional geological-geophysical model

Online: 19 September 2024 (14:53:35 CEST)

Show abstract| Download PDF| Share

The Huaniushan lead-zinc-silver deposit is a hydrothermal sedimentary exhalative deposit (SEDEX). The mining area has complex geological conditions. The main tectonic structure in the area is the Huaheitan-Shuangfengshan Fault (F3), which controls the distribution of strata and magmatic rocks. Since the discovery of the Huaniushan Lead-zinc-silver polymetallic deposit, there are diverse understandings of the deposit's genesis and mineralization law, making it challenging to meet the geological interpretation requirements of the Huaniushan Lead-zinc-silver polymetallic deposit. Moreover, a single geophysical exploration method utilizes limited rock physical parameters, making it difficult to effectively characterize underground structures. The integrated exploration of multiple geophysical methods can effectively integrate the geophysical characteristics of different rock physical parameters, reducing the multiplicity and uncertainty of geophysical data inverse interpretation. The comprehensive interpretation of three-dimensional inversion based on various geophysical data, the construction of geological-geophysical models based on geological grounds, the establishment of hidden ore exploration and positioning, and the rapid evaluation of geophysical technology systems are the current development trends in mineral exploration. In light of this, this paper conducts research on the three-dimensional inversion interpretation of the heavy magnetoelectric exploration data of the Huaniushan sedimentary exhalative deposit lead-zinc-silver polymetallic deposit in the mining area and constructs a three-dimensional geological-geophysical model of the study area based on the obtained three-dimensional physical structure of the underground three-dimensional density, magnetization intensity, resistivity, and polarizability structure of the study area, in combination with the information of related geology and drilling holes. It comprehensively interprets the favorable mineralization parts in the study area.

Preprint ARTICLE | doi:10.20944/preprints202403.0440.v1

Partial Substitution of Chemical N with Solid Cow Manure Improved Soil Ecological Indicators and Crop Yield in a Wheat-Rice Rotation System

Jintao Yu, Chun Zhang, Xuan Wang, Hongchuan Li, Yusef Kianpoor Kalkhajeh, Hongxiang Hu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: conventional fertilization; solid cow manure; crop quality; soil nutrients; ecological risk

Online: 7 March 2024 (13:10:19 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.1037.v1

Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm

Giovanna Giordano, Debora Guareschi, Elena Thai

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Uterine Tumor Resembling Ovarian Sex Cord Stromal Tumor; Uterine mesenchymal neoplasm; Polyphenotypic Neoplasm; Prognosis.

Online: 16 April 2024 (10:50:18 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202408.1232.v1

Feasibility of Emergency Flood Traffic Road Damage Assessment by Integrating Remote Sensing Images and Social Media Information

Hong Zhu, Jian Meng, Jiaqi Yao, Nan Xu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Multi-source heterogeneity; Flood disaster; Social media information; TextCNN-Attention; Transportation roads; Loss assessment

Online: 19 August 2024 (04:33:27 CEST)

Show abstract| Download PDF| Share

In the context of global climate change, the frequency of sudden natural disasters is increasing. Assessing traffic road damage post-disaster is crucial for emergency decision-making and disaster management. Traditional ground observation methods for evaluating traffic road damage are limited by the timeliness and coverage of data updates. Relying solely on these methods does not adequately support rapid assessment and emergency management during extreme natural disasters. Social media, a major source of big data, can effectively address these limitations by providing more timely and comprehensive disaster information. Motivated by this, we utilized multi-source heterogeneous data to assess the damage to traffic roads under extreme conditions and established a new framework for evaluating traffic roads in cities prone to flood disasters caused by rainstorms. The approach involves several steps: First, extracting the surface area affected by precipitation using a threshold method constrained by confidence intervals derived from microwave remote sensing images; Second, collecting disaster information from the Sina Weibo platform, where social media information is screened and cleaned. A quantification table for road traffic loss assessment was defined, and a social media disaster information classification model combining text convolutional neural networks and attention mechanisms was proposed (TextCNN-Attention Disaster Classification); Finally, matching traffic road information on social media with basic geographic data, visualizing the classification of traffic road disaster risk levels, and completing the assessment of traffic road disaster levels based on multi-source heterogeneous data. Using the "7.20" rainstorm event in Henan Province as an example, this study categorizes the disaster impact on traffic roads into five levels: particularly severe, severe, moderate, mild, and affected, as interpreted from remote sensing images. The evaluation framework for flood disaster traffic roads based on multi-source heterogeneous data provides important data support and methodological support for enhancing disaster management capabilities and systems.

Preprint ARTICLE | doi:10.20944/preprints202407.1019.v1

A Rationally Designed H5 Hemagglutinin Subunit Vaccine Provides Broad-Spectrum Protection against Various H5Nx highly Pathogenic Avian Influenza Viruses in Chickens

Xuxiao Zhang, Xin Li, Fushou Zhang, Xiaoping Cui, Xiaoqin Guo, Zhi Sun, Pengju Guo, Ming Liao, Ning Chen

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: avian influenza virus; H5 subtype; subunit vaccine; broad protection

Online: 12 July 2024 (08:42:33 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0026.v1

Molecular Prevalence, Genetic Diversity, and Tissue Tropism of Bartonella Species in Small Mammals from Yunnan Province, China

Pei-Yu Han, Fen-Hui Xu, Jia-Wei Tian, Jun-Ying Zhao, Ze Yang, Wei Kong, Bo Wang, Li-Jun Guo, Yun-Zhi Zhang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Bartonella; small mammals; genetic diversity; evolution; tissue tropism

Online: 1 April 2024 (17:07:19 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201701.0034.v1

Game Analysis of Low Carbonization for Urban Logistics Service Systems

Jidong Guo, Shugang Ma

Subject: Business, Economics And Management, Business And Management Keywords: 3PLs; E-business enterprise; low carbonization; game theory; Nash Equilibria

Online: 9 January 2017 (03:29:14 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0029.v1

Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review.

Renate Viebahn-Haensler, Olga León Fernández

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: redox bioregulation; mitochondriopathies; low-dose ozone concept; ozone therapy; oxidative stress; antioxidant capacity

Online: 1 May 2024 (07:29:18 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.0650.v1

Water Injection for Cloud Cavitation Suppression: Analysis on the Effects of Injection Parameters

Wei Wang, Zhijian Li, Xiang Ji, Yun Wang, Xiaofang Wang

Subject: Engineering, Marine Engineering Keywords: Cavitation suppression; Water injection; Flow control; Injection parameters; Energy performance

Online: 9 July 2024 (10:19:07 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0538.v1

Wastewater-Based Epidemiology for SARS-CoV-2 in Northern Italy: A Spatiotemporal Model

Matilde Fondriest, Lorenzo Vaccari, Federico Aldrovandi, Laura De Lellis, Filippo Ferretti, Carmine Fiorentino, Erica Mari, Maria Grazia Mascolo, Laura Minelli, Vincenza Perlangeli, Giuseppe Bortone, Paolo Pandolfi, Annamaria Colacci, Andrea Ranzi

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Wastewater-based epidemiology; SARS-CoV-2; COVID-19; wastewater; biodegradation; sewer network; spatiotemporal model; public health; early-warning system

Online: 8 April 2024 (14:48:16 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202407.0678.v1

A Terminal Residual Vibration Suppression Method of A Robot Based on Joint Trajectory Optimization

Liang Liang, Chengdong Wu, Shichang Liu

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: industrial robot; parameter identification; vibration suppression; optimal trajectory; Chebyshev collocation

Online: 9 July 2024 (08:24:56 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202409.0501.v1

Prospect on Damage Control in Current ASD Intervention

Qi Zhang, Qiang Li

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism; Immune stress; Brain damage; Damage control

Online: 6 September 2024 (09:40:08 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202409.1667.v1

Antioxidant Effects of Aromatic Plant Extracts in Neurodegenerative Diseases: A Review

Youyang Zhu, Miao Tian, Yuliang Qin, Ting Zhao, Zhaofu Li, Dongdong Qin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurodegenerative diseases; Oxidative stress; Antioxidants; Aromatic plants extracts

Online: 20 September 2024 (20:20:02 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202408.1076.v1

Tumor Heterogeneity in Gastrointestinal Cancer based on Multimodal Data Analysis

Dongmei Ai, Yang Du, Hongyu Duan, Juan Qi, Yuduo Wang

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: tumor heterogeneity; transcriptome profile; cancer classification; multiomics; cancer imaging

Online: 14 August 2024 (14:37:35 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202406.1703.v1

Distribution Characteristics and Genesis Mechanism of Ground Fissures in Three Northern Counties of the North China Plain

Chao Xue, Mingdong Zang, Zhongjian Zhang, Nengxiong Xu, Feiyong Wang, Cheng Hong, Guoqing Li, Fujiang Wang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Ground fissures; North China Plain; distribution characteristics; causative mechanism

Online: 25 June 2024 (00:31:48 CEST)

Show abstract| Download PDF| Share

The North China Plain is among the regions most afflicted by ground fissure disasters in China. Recent urbanization has accelerated ground fissure activity in the three counties of the northern North China Plain, posing significant threats to both the natural environment and socioeconomic sustainability. Despite the increased attention, a lack of comprehensive understanding persists due to delayed recognition and limited research. This study conducted field visits and geological surveys across 43 villages and 80 sites to elucidate the spatial distribution patterns of ground fissures in the aforementioned counties. By integrating these findings with regional geological data, we formulated a causative model to explain ground fissure formation. Our analysis reveals a concentration of ground fissures near the Niuxi and Rongxi faults, with the former exhibiting the most extensive distribution. The primary manifestations of ground fissures include linear cracks and patch-shaped collapse pits, predominantly oriented in east-west and north-south directions, indicating tensile failure with minimal vertical displacement. Various factors contribute to ground fissure development, including fault activity, ancient river channel distribution, bedrock undulations, rainfall, and ground settlement. Fault activity establishes a concealed fracture system in shallow geotechnical layers, laying the groundwork for ground fissure formation. Additionally, the distribution of ancient river channels and bedrock undulations modifies regional stress fields, further facilitating ground fissure emergence. Rainfall and differential ground settlement serve as triggering mechanisms, exposing ground fissures at the surface. This research offers novel insights into the causative mechanisms of ground fissures in the northern North China Plain, providing valuable scientific evidence for mitigating ground fissure disasters during the urbanization process in the region.

Preprint REVIEW | doi:10.20944/preprints202409.0184.v2

A Review of Vehicles for Fire Suppression

Osman Acar, Eija Honkavaara

Subject: Engineering, Mechanical Engineering Keywords: Wildfire; Firefighting technology; Firefighting vehicles

Online: 4 September 2024 (12:03:07 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0253.v2

The Purpose of Adrenarche Is Tumor Suppression: Identification of a Novel, Human-Specific, Kill-Switch Tumor Suppression Mechanism Dependent upon the Dramatic Adrenarchal Rise of Adrenal Androgens

Jonathan Wesley Nyce

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: p53; adrenarche; dehydroepiandrosterone; DHEA; DHEAS

Online: 13 April 2023 (05:01:41 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202408.2266.v1

Technological Interventions to Implement Prevention and Health Promotion in Cardiovascular Patients

Ayisha Zaka Bashir, Anji Yetman, Melissa Wehrmann

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Health promotion; cardiology; technology; cardiac rehabilitation; telemedicine and telehealth

Online: 30 August 2024 (15:36:00 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0614.v1

Suppression of Metastasis of Colon Cancer to Liver by Pretreatment With Extracellular Vesicles Derived From Nanog-Overexpressing Colon Cancer Cells

Takuya Henmi, Hideaki Matsuoka, Mikako Saito

Subject: Biology And Life Sciences, Life Sciences Keywords: Colon-26; Nanog; metastasis; macrophage; phagocytosis

Online: 11 June 2024 (08:05:28 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.0380.v1

Obesogens in Adolescence. Challenging Aspects and Prevention Strategies.

Marina Nicolaou, Meropi Toumba, Alexandros Kythreotis, Habib Daher, Nicos Skordis

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: endocrine disrupting chemicals; obesogens; obesity; children; adolescents; prevention strategies

Online: 5 April 2024 (06:51:44 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0913.v1

RNA Interference-Mediated Suppression of Ecdysone Signaling Inhibits Choriogenesis in two Coleoptera species

Xiao-Qing Zhang, Lin Jin, Wen-Chao Guo, Kai-Yun Fu, Guo-Qing Li

Subject: Biology And Life Sciences, Insect Science Keywords: Leptinotarsa decemlineata; Henosepilachna vigintioctopunctata; choriogenesis; ecdysone signal, chitin-like substance; eggshell

Online: 15 March 2024 (11:33:15 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202406.1897.v1

Research Progress on Starfish Outbreaks and Their Prevention and Utilization

Liang Qu, Yongxin Sun, Chong Zhao, Maurice R Elphick, Qingzhi Wang

Subject: Biology And Life Sciences, Aquatic Science Keywords: starfish; Asterias amurensis; outbreak; prevention; utilization

Online: 27 June 2024 (12:09:30 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.1491.v1

Review on the Impact of Iron Tailings on the Environment and Its Prevention and Control Strategies

Yunjie Bai, Weixing Liu, Aimin Yang, Bo Gao, Hao Li, Zhixiao Lin

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Iron tailings; Environmental impact; Water pollution; Air pollution; Resource utilization

Online: 23 May 2024 (10:37:44 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0253.v1

Prevalence and Prevention of Clinical Injuries Among Undergraduate Dental Students: A Post-COVID-19 Study

Maria Antoniadou, Maria Chanioti, Asteropi Pantelaki, Antonios Parasiris, Evangelia Piperi, Christos Rahiotis

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: percutaneous injuries; dentists; dental students; COVID-19 pandemic; dental students’ stress; dental school environment

Online: 5 June 2024 (08:25:21 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.1513.v1

Agricultural Disaster Prevention System: A Review of the Strategies in Taiwan

Ming-Hwi Yao, Yung-Heng Hsu, Ting-Yi Li, Yung-Ming Chen

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: weather forecast; early warning system; disaster prevention; crop; information and communication technology (ICT)

Online: 27 February 2024 (10:29:37 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.0949.v1

Cascade Clutter Suppression Method for Airborne FDA Radar Based on Elevation Oblique Subspace Projection and Azimuth-Doppler STAP

Rongwei Lu, Yifeng Wu, Lei Zhang, Ziyi Chen

Subject: Engineering, Electrical And Electronic Engineering Keywords: frequency diverse array (FDA); clutter suppression; space-time adaptive processing (STAP); moving targets detection (MTI)

Online: 14 August 2024 (03:03:43 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0709.v1

A 2.4 GHz Wide-Range CMOS Current-Mode Class-D PA with HD2 Suppression for Internet of Things Applications

Nam-Seog Kim

Subject: Engineering, Electrical And Electronic Engineering Keywords: Bluetooth low energy (BLE); Class-D power amplifier (PA); complementary metal–oxide–semiconductor (CMOS); current-mode; second harmonic distortion (HD2); internet of things (IoT); transmitter (TX); power efficiency; wireless sensor network (WSN); Zigbee

Online: 12 February 2024 (15:52:29 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1426.v1

Improving the Efficiency and Safety of Sentinel Stink Bug Eggs Using X-Rays

Evelyne Hougardy, Ronald P. Haff, Brian N. Hogg

Subject: Biology And Life Sciences, Insect Science Keywords: stink bug; egg parasitism; field monitoring; sentinel eggs; x-ray irradiation; egg sterilization

Online: 18 September 2024 (13:57:26 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1542.v1

Attitudes of Healthcare Professionals in an Autonomous Community in Spain towards Paediatric Influenza Vaccination

Jaime Jesús Pérez-Martín, Antonio Iofrío de Arce, Matilde Zornoza-Moreno

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Influenza vaccines; Healthcare professional; Attitude of Healthcare professional; intramuscular vaccine; Inhaled vaccine

Online: 24 April 2024 (07:26:27 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1724.v1

Data Loss Prevention Method Based on Multiprotocol Connectivity for IoT

Hamza Takrouni, Larbi Talbi, Youcef Fouzar

Subject: Engineering, Telecommunications Keywords: Internet of Things, Cloud Computing, Edge Computing, Big Data, IoT Communications Protocols

Online: 29 February 2024 (11:06:12 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201702.0107.v1

Maximum Storm Tide Response to the Intensity of Typhoons and Bathymetric Changes along the East Coast of Taiwan

Wen-Cheng Liu, Wei-Bo Chen, Lee-Yaw Lin

Subject: Engineering, Control And Systems Engineering Keywords: maximum storm tide; two-dimensional tide-surge modeling system; east coast of Taiwan; intensity of typhoon; bathymetric rise

Online: 28 February 2017 (13:00:56 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.0086.v1

Advancements in Circulating Tumor Cell Research: Bridging Biology and Clinical Applications

Philip Salu, Katie M. Reindl

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Circulating tumor cells; liquid biopsy; cancer research; metastasis; personalized medicine; single-cell sequencing; biomarkers.

Online: 4 March 2024 (09:27:46 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201608.0083.v1

The Joint Use of Multiple Satellite SAR Data and Geotechnical Models for the Study of the Shanghai Ocean-Reclaimed Lands

Antonio Pepe, Manuela Bonano, Qing Zhao, Tianliang Yang, Hanmei Wang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: deformation; interferometry; geotechnical models; non‐linear problem; synthetic aperture radar (SAR); time‐series

Online: 8 August 2016 (14:50:19 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.1588.v1

Cephalometric Evaluation of Children with Short Stature of Genetic Etiology. A Review

George Paltoglou, Nickolas Ziakas, George P. Chrousos, Christos Yapijakis

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: short stature; genetics; genetic syndromes; craniofacial morphology; cephalometric radiograph; growth hormone/insulin-like growth factor 1 axis; epiphyseal growth plate; cartilage extracellular matrix

Online: 24 May 2024 (11:17:53 CEST)

Show abstract| Download PDF| Share

Introduction: A plethora of biological molecules regulate chondrogenesis in the epiphyseal growth plate. Disruptions of quantity and function of these molecules can manifest clinically as stature abnormalities of various etiologies. Traditionally, the growth hormone/insulin-like growth factor 1 (IGF1) axis represents the etiological center of final stature attainment. Of note, little is known about the molecular events that dominate the growth of the craniofacial complex and its correlation with somatic stature. Aim: Given the paucity of the relevant data, this review discusses available information regarding potential applications of lateral cephalometric radiography as a potential clinical indicator of genetic short stature in children. Materials and Methods: A literature search was conducted in the PubMed electronic database using the key words: cephalometric analysis and short stature; cephalometric analysis and achondroplasia; cephalometric analysis and hypochondroplasia; cephalometric analysis and skeletal abnormalities; cephalometr* and SHOX; cephalometr* and CNP; cephalometr* and ACAN; cephalometr* and CNVs; cephalometr* and IHH; cephalometr* and FGFR3; cephalometr* and Noonan syndrome; cephalometr* and “Turner syndrome”; cephalometr* and achondroplasia. Results: In individuals with genetic syndromes causing short stature, linear growth of the craniofacial complex is confined, following the pattern of somatic short stature regardless of its etiology. The angular cephalometric measurements differ from the average height normal individuals and are suggestive of a posterior placement of the jaws and a vertical growth pattern of the face. Conclusion: The greater part of the existing literature regarding cephalometric measurements in short statured children with genetic syndromes provides qualitative data. Furthermore, cephalometric data for individuals affected with specific rare genetic conditions causing short stature, should be the focus of future studies. These quantitative data are required to potentially establish cut-off values to refer for genetic testing based on craniofacial phenotypes.

Preprint REVIEW | doi:10.20944/preprints202407.0190.v1

Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges

Riccardo Foti, Gabriele Storti, Marco Palmesano, Maria Giovanna Scioli, Elena Fiorelli, Sonia Terriaca, Giulio Cervelli, Bong Sung Kim, Augusto Orlandi, Valerio Cervelli

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: adipose-derived stem cells; mesenchymal stem cells; ageing; senescence; stem cell therapy; senescence; diabetes; senolytic drugs

Online: 2 July 2024 (10:24:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0958.v1

Comparison of the HBSC Results of the Visegrad Countries with the Health Behavior of Young People with Disabilities Living in Hungary: A Cross-Sectional Study

Agota Barabas, Attila Csaba Nagy, Viktoria Pazmany, Anita Katalin Grestyak Molnarne, Nemeth Agnes, György Jona, Agnes Santha, Peter Takacs, Emil Toldy, Renata Javorne Erdei

Subject: Public Health And Healthcare, Other Keywords: health; health behavior; disability; Visegrad Group

Online: 18 March 2024 (09:10:06 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.2477.v1

Sublethal Sodium Hypochlorite Exposure: Impact on Resistance-Nodulation-cell Division (RND) Efflux Pump Overexpression, and Cross-Resistance to Imipenem

Ji-Hyun Nam, Jung Sik Yoo

Subject: Public Health And Healthcare, Primary Health Care Keywords: cross-resistance; imipenem antibiotics; NaOCl disinfectant; resistance-nodulation-cell division (RND) efflux pump

Online: 31 July 2024 (08:32:35 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1169.v1

Puzzling Regulation of Interferon Signaling System by p53 Tumor Suppressor Protein

Agnieszka Będzińska, Barbara Łasut-Szyszka, Małgorzata Krześniak, Agnieszka Gdowicz-Kłosok, Marek Rusin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: p53; interferon; STAT1; NK-92; caspase-1; innate immunity

Online: 17 April 2024 (14:47:03 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1207.v1

How the Choice of the Starting Time of the Observation Day May Affect Daily Precipitation Amounts and Extremes: Problem Analysis and Adjustment Methods

Francesca Becherini, Claudio Stefanini, Antonio Della Valle, Francesco Rech, Fabio Zecchini, Dario Camuffo

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: daily precipitation; time of observation; time series; aggregation method; adjustment method; hourly dataset; daily extremes

Online: 22 February 2024 (01:19:32 CET)

Show abstract| Download PDF| Supplementary Files| Share

The study of precipitation amount at different time scales constitutes an important issue in climate research and risk assessment. When dealing with daily totals, a frequent but sometimes underestimated problem is at what time the observation day begins. The choice of different starting times may lead to incompatibility between stations and incorrect identification of extreme events. In this work, the problem of temporal misalignment between precipitation datasets characterized by different starting time of the observation day is analyzed. The most widely used adjustment methods (1day and uniform shift) and two methods based on reanalysis (NOAA and ERA5) are evaluated in terms of temporal alignment, precipitation statistics and percentile distributions. As test series, the precipitation amount collected from 9 a.m. local time (09 LT) on the previous day to 09 LT on the target day (9-9 datasets) of the Padua and nearby stations in the period 1993-2022 have been selected. Results show that the reanalysis-based methods, in particular ERA5, outperform the others in temporal alignment, regardless the station. But, for the periods in which reanalysis data are not available, “1day” method, which shifts the daily amount back one calendar day, and “unif” method, which distributes uniformly the daily total from a 2-day moving window surrounding the target date, can be considered valid alternatives. On the other side, concerning the precipitation statistics, the reanalysis-based methods are not the best option, as they increase the precipitation frequency and reduce the mean value over wet days, NOAA much more than ERA5. Nevertheless, the uniform method provides a larger deviation from the original daily series. The use of the series of a station nearby the target one, which is mandatory in case of missing data, gives similar or better results than applying any adjustment method to the 9-9 series. General conclusions can hardly be drawn as they depend on the method and station. For the Padua dataset, the analysis was repeated at monthly and seasonal resolution. In general, the adjustment series show the most relevant changes in the precipitation statistics in summer and less temporal alignment with the original series in summer and autumn, the two seasons mainly affected by heavy rains in Padua. Finally, the percentiles distribution, analyzed for all the methods and stations, indicates that any adjustment method underestimates the percentile values, except ERA5. Only Legnaro, the station most correlated with Padua, gives results like ERA5.

Preprint ARTICLE | doi:10.20944/preprints202409.1151.v1

Whole-Genome Sequencing Analysis of Antimicrobial Resistance, Virulence Factors, and Genetic Diversity of Salmonella Isolated from Wenzhou, China

Yafang Jin, Yi Li, Shaojie Huang, Chengji Hong, Xucong Feng, Huidi Cai, Yanmei Xia, Shengkai Li, Leyi Zhang, Yongliang Lou, Wanchun Guan

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Salmonella; antimicrobial resistance; pathogenicity islands; cgMLST; Whole genome sequencing

Online: 16 September 2024 (03:20:34 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1293.v1

Microbiological Diagnosis – an Important Tool for Prevention and Management of Peri-Implant Infective Diseases

Adrian Țandără, Cristian Funieru, Oana Slușanschi, Cristina Preoteasa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: peri-implant infective diseases; microbiota; antibiogram

Online: 18 September 2024 (04:51:09 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202407.0418.v1

LCK Function and Modulation: Immune Cytotoxic Response and Tumor Treatment. More than a Simple Event.

Juan Bautista De Sanctis, Jenny Valentina GARMENDIA, Hana Duchová, Viktor Valentini, Alex Puskasu, Agata Kubíčková, Marián Hajdúch

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Src kinases, Lck, hematologic tumors, solid tumors, T-cell cytotoxicity, NK cytotoxicity, CAR-T cell, cell proliferation, cell adhesion.

Online: 4 July 2024 (13:31:00 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.1060.v1

Assessment of Earthquake Damage and Economic Recovery in Hatay Province, Turkey Using Nighttime Light Data

Feng Li, Shunbao Liao, Xiaobo Zhang, Tianxuan Liu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: rapid assessment method; Turkey earthquake damage; economic recovery assessment; Hatay Province; nighttime light; NPP-VIIRS; SDGSAT-1

Online: 12 July 2024 (13:50:27 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.1311.v1

Exosome-Like Systems: From Therapies to Vaccination for Cancer Treatment and Prevention—Exploring the State of the Art

Hamid Heydari Sheikhhossein, Francesca Iommelli, Natalia Di Pietro, Maria Cristina Curia, Adriano Piattelli, Rosanna Palumbo, Giovanni N Roviello, Viviana De Rosa

Subject: Biology And Life Sciences, Life Sciences Keywords: exosomes; cancer vaccines: immune system

Online: 19 April 2024 (08:09:25 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0577.v1

Factors Associated With Complications of Snakebite Envenomation in Health Facilities in the Cascades Region of Burkina Faso, 2016 to 2021

Réné Kinda, Sidikiba Sidibe, Dramane Zongo, Tieba Millogo, Alexandre Delamou, Seni Kouanda

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Snakebite; Envenomation; Complications

Online: 11 June 2024 (08:48:50 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.1614.v1

Molecular Circuits of Immune Sensing and Response to Oncolytic Virotherapy

Darshak K Bhatt, Toos Daemen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: molecular pathways; oncolytic virus; pattern recognition receptors; transcription factors

Online: 26 March 2024 (16:57:15 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1231.v1

Suppression of Ventilation-Induced Diaphragm Fibrosis through the Phosphoinositide 3-Kinase-γ in a Murine Bleomycin-Induced Acute Lung Injury Medel

Li-Fu Li, Chung-Chieh Yu, Chih-Yu Huang, Huang-Pin Wu, Chien-Ming Chu, Ping-Chi Liu, Yung-Yang Liu

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: apoptosis; diaphragm fibrosis; phosphoinositide 3-kinase-g; ventilator-induced diaphragm dysfunction

Online: 18 April 2024 (10:06:43 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202406.1145.v1

Serum-Derived Macrophage-Activating Factor Exhibits Anti-Tumor Activity via M2-to-M1 Macrophage Reprogramming

Tsuyoshi Takara, Rei Takara, Aya Kobayashi, Hina Shirakata, Shinobu Ambai, Yusei Shinohara, Yoshihiro Uto

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: group-specific component protein-derived macrophage-activating factor; RAW264.7 macrophages; M1/M2 macrophages; macrophage polarization; anti-tumor effects

Online: 17 June 2024 (12:43:17 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0738.v1

An Overview of Nanoparticle-Based Delivery Platforms for Vaccines

Yang Lin, Xuehua Chen, Ke Wang, Li Liang, Hongxia Zhang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Vaccine platform; Nanoparticles; mRNA vaccine; Lipid-based nanoparticles; Anti-tumor immunity

Online: 13 May 2024 (12:14:58 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.0567.v1

Fractal Dimension Analysis of the Tumor Microenvironment in Cutaneous Squamous Cell Carcinoma: Insights into Angiogenesis and Immune Cell Infiltration

Alexandra Buruiană, Mircea-Sebastian Șerbănescu, Bogdan Pop, Bogdan-Alexandru Gheban, Ioana-Andreea Gheban-Roșca, Raluca Maria Hendea, Carmen Georgiu, Doinița Crișan, Maria Crișan

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: fractal dimension; cutaneous squamous cell carcinoma; digital image analysis; tumor microenvironment; angiogenesis; immune cells

Online: 9 September 2024 (12:44:38 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202403.1104.v1

Health Benefits of White Mulberry, Sea–Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn — Prevention and Treatment of Cardiovascular Disease

Aleksandra Witkowska, Anna Gryn–Rynko, Patrycja Syrkiewicz, Klaudia Kitala–Tańska, Michał S Majewski

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: white mulberry; sea– buckthorn; garlic; lily of the valley; motherwort; hawthorn

Online: 22 March 2024 (07:33:56 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0230.v1

Magnesium Ion: A New Switch in Tumor Treatment

Leyi Huang, Renxi Lin, Jiaxi Chen, Yuanlin Qi, Ling Lin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Magnesium Ion; Mitochondria; Mitochondrial Function; Energy Metabolism; Cancer Therapy

Online: 6 May 2024 (05:45:17 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.1084.v1

Histology of the Primary Tumor, Lymph Node, and Tumor Size upon Neoadjuvant Treatment Predict Effectiveness of Complete Pathologic Response in Patients Undergoing Primary Lung Cancer Resections

Fuad Damirov, Mircea Gabriel Stoleriu, Farkhad Manapov, Enole Boedeker, Sascha Dreher, Sibylle Gerz, Thomas Hehr, Evelin Sandner, German Ott, Rudolf Alexander Hatz, Gerhard Preissler

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lung cancer; PET/CT-scan; lymph node staging; neoadjuvant therapy; pathological response; tumor regression; overall survival

Online: 15 July 2024 (13:04:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0215.v1

Effects of Xylitol on Tumor Progression in Syngeneic Mice Cancer Models

Mark Cannon, Ashlee Cosantino, Mari Tesch, Fernando Valerio-Pascua, Franck Rahaghi, Lori Tran, Navdeep Chandel, Nayereh Ghoreishi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Xylitol; tumor progression; syngeneic mice models; cancer treatment; melanoma; mammary carcinoma; mouse cancer models; sugar alcohol; oncology; metabolomics

Online: 6 May 2024 (08:05:33 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0168.v1

Preparedness, Prevention, Investigation, and Response to the Emergence of Mpox in Khartoum, Sudan in 2022

Yousif Ali, Emmanuel Edwar Siddig, Mohammed Osman, Nouh Saad Mohamed, Ahmed Musa, Ayman Ahmed

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Mpox; Outbreak; Pandemic Preparedness and Response; global health emergency of international concern; epidemiology, Zoonoses, One Health; Global Health Security

Online: 4 June 2024 (10:43:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0846.v1

DPEP Inhibits Cancer Cell Glucose Uptake, Glycolysis and Survival by Upregulating Tumor Suppressor TXNIP

Qing Zhou, Trang Thi Thu Nguyen, Jeong-Yeon Mun, Markus D Siegelin, Lloyd A Greene

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: TXNIP; glycolysis; CEBPB; CEBPD; ATF5; cell-penetrating; apoptosis; Dpep; glucose uptake

Online: 13 May 2024 (12:21:07 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202409.0999.v1

Assessing the Feasibility of Handheld Cameras to Increase Access to Teleretinal Diabetic Retinopathy Screenings in Safety-Net Clinics in Los Angeles

Gabrielle Green, Roxana Flores, Elvia Figueroa, Tony Kuo, Lauren Daskivich

Subject: Public Health And Healthcare, Primary Health Care Keywords: Teleretinal diabetic retinopathy screenings; handheld cameras; safety-net; diabetes; feasibility

Online: 12 September 2024 (16:01:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0459.v1

Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion

Dewi Megawati, Jeannine N. Stroup, Chorong Park, Taylor Clarkson, Loubna Tazi, Greg Brennan, Stefan Rothenburg

Subject: Biology And Life Sciences, Virology Keywords: Protein kinase R, poxviruses, K3L, yatapoxvirus, translational regulation

Online: 7 June 2024 (08:08:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.2567.v1

Peripancreatic Head Paraganglioma Versus Neuroendocrine Tumor, a Roller Coaster Diagnostic Dilemma in Fine Needle Aspiration Cytology with a Note: “A Definite Diagnosis Cannot Be Concluded”

Zahida Niaz, Babikir Ismail, Abdullah Yahya Al Farai, Ramesh Babu Telugu, Ibrahim Hassan Al Haddabi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Paraganglioma; Neuroendocrine neoplasm; Synaptophysin

Online: 31 July 2024 (11:38:28 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202404.1562.v1

Clip Closure and PuraStat for Prevention of Clinically Significant Delayed Bleeding after Colorectal Endoscopic Submucosal Dissection: A Prospective, Observational Study

Mihai Ciocirlan, Dana Bilous, Andrei Gila, Daniel Corneliu Leucuta, Daniela Elena Mihaila, Adrian Tulin, Anca Gheorghiu, Elena Tianu, Catalina Vladut

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: endoscopic submucosal dissection; clip closure; PuraStat; muscle retracting sign; colorectal mixed neuroendocrine carcinoma

Online: 24 April 2024 (09:58:17 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.0894.v1

The Association between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank

Qiuge Zhang, Xueting Qi, Zhaoguo Wang, Dongfeng Zhang, Tong Wang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: sleep disorder; diet; vitamin c; UK Biobank

Online: 11 September 2024 (15:20:48 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202407.0360.v1

Infection Prevention and Control (IPC) Strategies According to the Type of Multidrug Resistant (MDR) Bacteria and Candida Auris in Intensive Care (ICU): A Pragmatic Resume, Pathogens R0, and Cost-Effectiveness Analysis

Chiara Fanelli, Laura Pistidda, Pierpaolo Terragni, Daniela Pasero

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Infection prevention and control; hospital-acquired infections; outbreak; multidrug resistant bacteria; acinetobacter baumanii; candida auris; vre; kpc; basic reproduction number; decolonization

Online: 3 July 2024 (16:11:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1916.v1

TIM3 or HAVCR2 in Breast Cancer Instead of Suppression May Invoke Immune Action in Tumor Micro Environment

ANUPAM BASU, ARUNITA GHOSH, Barnali Dolui, Banani Majumdar, Pallavi Krishna, Arghya Bandopadhaya

Subject: Biology And Life Sciences, Life Sciences Keywords: Breast Cancer; ; Triple negative breast cancer; T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3); HAVCR-2; TCGA; BRCA; TIMER2.0; UALCAN; GEPIA

Online: 29 January 2024 (02:11:05 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1390.v1

Suppression PCR-Based Selective Enrichment Sequencing for Pathogen and Antimicrobial Resistance Detection on Cell-Free DNA in Sepsis - A Targeted, Blood Culture Independent Approach for Rapid Pathogen and Resistance Diagnostics in Septic Patients

Mirko Sonntag, Vanessa K. Elgeti, Yevhen Vainshtein, Lucca Jenner, Jan Mueller, Thorsten Brenner, Sebastian O. Decker, Kai Sohn

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: sepsis; antimicrobial resistances; cell-free DNA; precision diagnostics; Next-Generation sequencing; suppression PCR; real-time diagnostics; nanopore sequencing

Online: 22 April 2024 (10:13:14 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202402.0641.v1

Plant-Derived Bioactive Compounds: Exploring Neuroprotective, Metabolic, and Hepatoprotective Effects for Health Promotion and Disease Prevention

Rosa Direito, Sandra Maria Barbalho, Bruno Sepodes, Maria Eduardo Figueira

Subject: Biology And Life Sciences, Food Science And Technology Keywords: by-products; berries; artichoke; grapevine; gooseberry; polygonoideae plants; olive oil; inflammation

Online: 12 February 2024 (07:41:38 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.0464.v1

Evaluation of Psychosomatic, Respiratory, and Neurocognitive Health in COVID-19 Survivors 12 Months after ICU Discharge

Nicolas Germann, Daria Amozova, Kristina Göhl-Freyn, Tim Fischer, Manuel Frischknecht, Gian-Reto Kleger, Urs Pietsch, Miodrag Filipovic, Martin H. Brutsche, Thomas Frauenfelder, Christian R. Kahlert, Dagmar A. Schmid, Werner C. Albrich

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; Intensive Unit Care; ICU; Predictive Model; Psychosomatic Health

Online: 5 July 2024 (00:23:15 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1101.v1

Hydrogeochemical Characteristics of Earthquake-Related varied-temperature Springs along the Eastern Kunlun Fault Zone, China

Chao Lu, Xiaocheng Zhou, Jiyi Jiang, Jingchao Li, Jing Li, Jing Wu, Xiaoyi Zhu, Jiang Li, Gaoyuan Xing, Shihan Cui

Subject: Environmental And Earth Sciences, Other Keywords: varied-temperature water; hydrogeochemistry; isotopes; seismic precursor; Eastern Kunlun Fault

Online: 19 March 2024 (08:53:36 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.1264.v1

Microwave Corona Breakdown Suppression of Microstrip Coupled-Line Filter Using Lacquer Coating

Ming Ye, Shaoguang Hu, Rui Wang, Yong Zhang, Yongning He

Subject: Engineering, Electrical And Electronic Engineering Keywords: coupled-line filter; dielectric coating; microstrip circuits; microwave corona breakdown suppression ;

Online: 18 June 2024 (13:36:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.2037.v1

A Comparison of Tools That Identify Tumor Cells by Inferring CNVs from Single-Cell Experiments in Pancreatic Ductal Adenocarcinoma

Daisy J. A. Oketch, Matteo Giulietti, Francesco Piva

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pancreatic ductal adenocarcinoma (PDAC); single-cell RNA sequencing (scRNA-seq); Copy number variations (CNVs).

Online: 25 July 2024 (12:07:10 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202405.1745.v1

Early Mediterranean-Based Nutritional Intervention Reduces the Rate of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Post-Hoc Analysis of the San Carlos Gestational Prevention Study

Rocio Martin-O´Connor, Ana M. Ramos-Leví, Verónica Melero, María Arnoriaga-Rodríguez, Ana Barabash, Johanna Valerio, Laura Del Valle, María Paz De Miguel Novoa, Angel Díiaz, Cristina Familiar, Inmaculada Moraga, Alejandra Durán, Martín Cuesta, Maria Jose Torrejón, Mercedes Martinez-Novillo, Clara Marcuello, Mario Pazos, Miguel Ángel Rubio-Herrera, Pilar Matía-Martín, Alfonso Luis Calle-Pascual

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: obesity; overweight; metabolic syndrome; fasting blood glucose; mediterranean diet

Online: 27 May 2024 (13:30:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0429.v1

Timber-Based Strategies for Seismic Collapse Prevention and Energy Performance Improvement in Masonry Buildings

Davide Cassol, Maja Danovska, Alessandro Prada, And Ivan Giongo

Subject: Engineering, Civil Engineering Keywords: unreinforced masonry; seismic retrofit; energy efficiency; timber panels; timber strong-backs; thermal transmittance u-value; periodic thermal properties; transient method; response factors

Online: 7 November 2023 (09:32:52 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201611.0067.v1

Review on Usage of Vancomycin in Livestock and Humans: Maintaining its Efficacy, Prevention of Resistance and Alternative Therapy

P. N. K. WIJESEKARA, W. W. Kumbukgolla, Jayaweera Arachchige Asela Sampath Jayaweera, D. S. Rawat

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: vancomycin; broad view; veterinary use at a glance; rational use; alternatives

Online: 12 November 2016 (11:09:37 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1653.v2

The p53 tumor suppressor protein activates transcription of DUSP13 isoform from the alternative promoter in intron

Małgorzata Krześniak, Barbara Łasut-Szyszka, Agnieszka Będzińska, Agnieszka Gdowicz-Kłosok, Marek Rusin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: p53; MDM2; DUSP13; alternative promoter; dual-specificity phosphatase

Online: 26 February 2024 (16:55:16 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202408.2145.v1

Viruses Identified in Shrews (Soricidae) and Their Biomedical Significance

Huan-Yu Gong, Rui-Xu Chen, Su-Mei Tan, Xiu Wang, Ji-Ming Chen, Yuan-Long Zhang, Ming Liao

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: shrew; virus; diversity; public health; epidemiology; risk

Online: 29 August 2024 (12:13:55 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202408.2245.v1

Comparative Performance of Autoencoders and Traditional Machine Learning Algorithms in Clinical Data Analysis for Predicting Post-Staged GKRS Tumor Dynamics

Simona Ruxandra Volovăț, Tudor Ovidiu Popa, Dragoș Rusu, Lăcrămioara Ochiuz, Decebal Vasincu, Maricel Agop, Călin Gheorghe Buzea, Cristian Constantin Volovăț

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: gamma knife radiosurgery (GKRS); brain metastasis; tumor dynamics forecasting; machine learning models; autoencoders

Online: 2 September 2024 (11:20:28 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.0075.v1

Influence of the Opening Time Interval of Gate Signals on Suppression of Horizontally-Polarized Signal of an Infrared Pulsed Laser

You Wang, Jing Liu

Subject: Physical Sciences, Optics And Photonics Keywords: Nd:YVO4 pulsed lasers; “ match-head” effect; Giant pulse suppression; Abnormal horizontally polarized emission; Slope duration of RF signals

Online: 2 September 2024 (11:00:18 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202407.2238.v2

Challenges and Advances in Cervical Cancer Prevention for HIV-Positive Individuals

Angel Justiz-Vaillant, Darren Gopaul, Reinand Thompson, Odalis Asin-Milan, Rodolfo Arrozarena-Fundora, Sachin Soodeen, Chandrashekhar Unakal

Subject: Biology And Life Sciences, Virology Keywords: HPV; Prevalence; Vaccination strategy; HPV screening; Cervical intraepithelial neoplasia

Online: 19 September 2024 (11:47:05 CEST)

Show abstract| Download PDF| Share

Since the identification of acquired immunodeficiency syndrome (AIDS) in 1981, approximately 85.6 million people have been infected with HIV, resulting in 40.4 million deaths. As of 2022, 53% of the 39 million people living with HIV are women and girls. Despite the advent of antiretroviral therapy (ART) improving survival rates, cervical cancer remains prevalent among HIV-infected individuals. By 2030, cervical cancer is projected to cause 727,500 new cases and 432,000 deaths globally. Human papillomavirus (HPV) is a well-known cause of cervical cancer, with HIV infection exacerbating the prevalence of high-risk HPV (HR-HPV) and cervical intraepithelial neoplasia (CIN). HIV and HPV share transmission routes, and HIV worsens cervical carcinogenesis by inhibiting tumour suppressor genes and altering cell cycle regulation. Chronic inflammation and cytokine imbalances, notably increased IL-10 levels, are linked to cervical cancer progression. Despite ART improving overall health, cervical cancer remains a significant issue, highlighting the need for better screening and prevention measures. A cross-sectional study in Brazil evaluated cytokine levels in cervicovaginal lavage among HIV-positive women, revealing a high prevalence of specific HPV types. ART has been shown to reduce the likelihood of developing squamous intraepithelial lesions (SILs) and HR-HPV prevalence, although its impact on invasive cervical cancer remains inconclusive. In a study in Accra, 250 sexually active HIV-positive women exhibited a high HPV prevalence, emphasising the need for regular screening. HPV testing, visual inspection with acetic acid (VIA), and cytology-based tests are primary screening methods, each with specific advantages and limitations. A systematic review and meta-analysis indicated that ART is associated with a lower prevalence of HR-HPV and high-grade cervical lesions, suggesting that early ART initiation may reduce cervical lesion incidence and progression. HPV is a significant cause of sexually transmitted diseases, with high prevalence in sub-Saharan Africa. Studies show a substantial burden of HPV among men in the region, underscoring the potential benefits of HPV vaccination programs. A study in Tanzania highlighted a high prevalence of HR-HPV among HIV-positive men, suggesting the efficacy of HPV vaccines irrespective of HIV status. Cervical cancer rates in sub-Saharan Africa are alarmingly high, necessitating targeted vaccination and prevention strategies.

Preprint CASE REPORT | doi:10.20944/preprints202407.1852.v1

A Rare Case of Breast Metastasis from a Primary Lung Tumor: Case Report

Raquel Diaz, Federica Murelli, Letizia Cuniolo, Chiara Cornacchia, Francesca Depaoli, Cecilia Margarino, Chiara Boccardo, Marco Gipponi, Simonetta Franchelli, Marianna Pesce, Barbara Massa, Silvia Bozzano, Valentina Barbero, Franco De Cian, Piero Fregatti

Subject: Medicine And Pharmacology, Surgery Keywords: breast cancer; breast metastasis; lung cancer

Online: 24 July 2024 (07:22:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1606.v1

Dietary Vitamin D Intake in Premenopausal Moroccan Women: Food Sources, Socio-Demographic Determinants and Correlation with 25-Hydroxyvitamin D Levels

Noura Zouine, Ilham Lhilali, Lode Godderis, Adil El Midaoui, Samir El Jaafari, Younes Zegzouti Filali

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: dietary intake; food sources; food fortification; sociodemographic; serum 25-hydroxyvitamin D; sun exposure; BMI; premenopausal women

Online: 20 September 2024 (09:32:24 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.1414.v1

The Veterinarian’s Role in Biocontainment Research Animal Facilities and Prevention of Spread of Pathogens in Africa

John Kudakwashe Chipangura, Abdussamad M. Abdussamad, David I. Lewis

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Veterinarian; Biocontainment research animal facility; Epicentre; Pathogens; Contamination

Online: 22 April 2024 (14:02:12 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.2067.v1

Maternal Vaccination for the Prevention of Infantile RSV Disease: An Overview of the Authorized, In-Progress, and Unsuccessful Vaccine Candidates.

Georgios Papazisis, Xanthippi Topalidou

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: infant immunity; maternal antibody transfer; respiratory syncytial virus; maternal immunization; RSV vaccine; clinical trial; safety; immunogenicity

Online: 30 May 2024 (14:23:14 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.2143.v1

Development of Novel Bioluminescent Biosensors Monitoring Conformation and Activity of Merlin Tumor Suppressor

Alex Pipchuk, Tynan Kelly, Madeleine Carew, Christopher Nicol, And Xiaolong Yang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Hippo Pathway; Merlin; tumor suppressor; Biosensor; NanoLuc; NanoBiT; Cell contact inhibition

Online: 28 December 2023 (05:31:44 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0960.v1

Bridging the Gap: Exploring Interpretability in Deep Learning Models for Brain Tumor Classification from MRI Images

Wandile Nhlapho, Marcellin Atemkeng, Yusuf Brima, Jean-Claude Ndogmo

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: transfer learning; deep learning; brain tumor classification; explanability and interpretability; Grad-Cam++; integrated gradients

Online: 19 February 2024 (10:21:08 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1649.v1

Targeting MutT homolog 1 (MTH1) for breast cancer suppression by a novel MTH1 inhibitor MA-24 with tumor-selective toxicity

Nannan Kang, Jun Ma, Yuling Hu, Rongrong Di, Lei Wang, Xuanling Zhang, Yisheng Lai, Yu Liu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Breast cancer, MutT homolog 1(MTH1), Antitumor activity, Oxidized nucleotide, MA-24

Online: 21 December 2023 (11:49:21 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202001.0295.v1

Suppression of Hepatocyte Nuclear Factor 4 Alpha by Long-Term Infection of Hepatitis B Virus Contributes to Tumor Cell Proliferation

Soree Park, Yea Na Ha, Mehrangiz Dezhbord, Ah Ram Lee, Eun-Sook Park, Yong Kwang Park, Juhee Won, Na Yeon Kim, Soo Yeun Choo, Jae Jin Shin, Chang Hyun Ahn, Kyun-Hwan Kim

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis B virus; hepatocyte nuclear factor 4 alpha; long-term infection; ERK signaling pathway

Online: 25 January 2020 (15:25:57 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202009.0197.v2

Scholarship Suppression: Theoretical Perspectives and Emerging Trends

Sean Stevens, Lee Jussim, Nathan Honeycutt

Subject: Social Sciences, Psychology Keywords: academic freedom; free speech; censorship; free inquiry; thought suppression

Online: 12 October 2020 (10:07:22 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0293.v1

Predicting Tumor Dynamics Post - staged GKRS: Machine Learning Models in Brain Metastases Prognosis

Ana Maria Trofin, Calin Gh. Buzea, Razvan Buga, Maricel Agop, Lacramioara Ochiuz, Dragoș Teodor Iancu, Lucian Eva

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: gamma knife radiosurgery (GKRS); brain metastasis; tumor dynamics forecasting; machine learning models; feature importance

Online: 6 May 2024 (10:47:26 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0571.v1

Unselective Measurement of Tumor‐to‐Stroma Proportion in Colon Cancer at the Invasion Front– an Elusive Prognostic Factor. Original Patient Data and Review of the Literature

Zsolt Fekete, Patricia Ignat, Amelia Cristina Resiga, Nicolae Todor, Alina-Simona Muntean, Liliana Resiga, Sebastian Curcean, Gabriel Lazar, Alexandra Gherman, Dan Eniu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: fibrosis; tumor stroma; stroma to tumor ratio; pathology markers; colon cancer; adjuvant treatment; invasion front

Online: 8 April 2024 (14:35:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1167.v1

Discovery of Novel Potential Prognostic Marker and Targeted Therapy to Overcome Chemotherapy Resistance in an Advanced Stage Wilms’ Tumor

Pongsakorn Choochuen, Natakorn Nokchan, Natthapon Khongcharoen, Wison Laochareonsuk, Komwit Surachat, Thirachit Chotsampancharoen, Thanit Sila, Surasak Sangkhathat

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Wilms’ tumor; Chemotherapy resistance; Biomarkers; Somatic mutation; Targeted therapy; Cancer-driver mutation

Online: 17 April 2024 (15:03:01 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Search Results

38270 articles found