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Preprint ARTICLE | doi:10.20944/preprints202406.0388.v1

Human Upper Limb Movement Classification using Machine Learning on Sensor Data

Sabahat Gulrez, Azizur Rehman, Ashad Kabir

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Machine learning; Upper limb; Movement

Online: 6 June 2024 (12:42:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1093.v1

IoT Wearable Sensors for Automatic Boxing Punch Recognition and Classification Based on Upper Limb Biomechanics

Saravanan Manoharan, John Warburton, Ravi Sadananda Hegde, Ranganathan Srinivasan, Babji Srinivasan

Subject: Engineering, Bioengineering Keywords: IoT Wearables; punch Detection and Classification; Computer Vision; Punch Key Performance Indicator (KPI)

Online: 14 July 2024 (03:11:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0384.v1

Controlling Upper Limb Prostheses Using Sonomyography (SMG): A Review

Vaheh Nazari, Yong-Ping Zheng

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Controlling system; human machine interface; machine learning; non-invasive sensor; prosthesis, sonomyography.

Online: 23 January 2023 (01:43:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1235.v1

Patient’s Healthy Limb Motion Characteristics Based Assist-as-Needed Control Strategy for Upper-Limb Rehabilitation Robot

Bingjing Guo, Zhenzhu Li, Mingxiang Huang, Xiangpan Li, Jianhai Han

Subject: Engineering, Mechanical Engineering Keywords: upper-limb rehabilitation robot; assist-as-needed control; endpoint stiffness estimation; stiffness mapping algorithm; surface electromyographic signal

Online: 16 January 2024 (12:33:07 CET)

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The implementation of a progressive rehabilitation training model to promote patients’ motivation efforts can greatly restore the damaged central nervous system function in patients. The patients’ active engagement can be effectively stimulated by assist-as-needed (AAN) robot rehabilitation training. However, its application in robotic therapy has been hindered by a simple determination method of robot assisted torque which focuses on the evaluation only of the affected limb's movement ability. Moreover, the expected effect of assistance depends on the designer, which deviates from the patient's expectations, and its applicability to different patients is deficient. In this study, we propose a control method with personalized treatment features based on the idea of estimating and mapping the stiffness of the patient’s healthy limbs. This control method comprises an interactive control module in the task-oriented space based on the quantitative evaluation of motion needs and an inner loop position control module for the pneumatic swing cylinder in the joint space. An upper limb endpoint stiffness estimation model is constructed and a parameter identification algorithm is designed. The upper limb endpoint stiffness which characterizes the patient's ability to complete training movements is obtained by collecting surface electromyographic (sEMG) signals and human-robot interaction forces during patient movement. Then the motor needs of the affected limb when completing the same movement are quantified based on the performance of the healthy limb. A stiffness mapping algorithm is designed to dynamically adjust the rehabilitation training trajectory and auxiliary force of the robot based on the actual movement ability of the affected limb, achieving AAN control. Experimental studies were conducted on a self-developed pneumatic upper limb rehabilitation robot, and the results showed that the proposed AAN control method can effectively estimate the patient's movement needs and achieve progressive rehabilitation training. The rehabilitation training robot that simulates the movement characteristics of the patient's healthy limbs drives the affected limb, making the intensity of the rehabilitation training task more in line with the patient's pre-morbid limb use habits, and also beneficial for the consistency of bilateral limb movements.

Preprint REVIEW | doi:10.20944/preprints202206.0083.v1

On the Role of Robotic Assistance in Upper-Limb Neurorehabilitation

Aravind Nehrujee, Sujatha Srinivasan, Sivakumar Balasubramanian

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: robotic assistance; Hebbian learning; sensorimotor recovery; upper-limb rehabilitation; stroke; re-habilitation robots

Online: 6 June 2022 (10:08:13 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202407.0355.v1

A Novel de Novo Missense Mutation in KIF1A Associated with Young-Onset Upper-Limb Amyotrophic Lateral Sclerosis

Emilien Bernard, Florent Cluse, Adrien Bohic, Marc Hermier, Cédric Raoul, Pascal Leblanc, Claire Guissart

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Amyotrophic Lateral Sclerosis; Genome sequencing; KIF1A; de novo mutation

Online: 3 July 2024 (15:27:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0290.v1

Intelligent Image Recognition System for Preventing Wrong Side Upper Limb Surgery

Yi-Chao Wu, Chao-Yun Chang, Yu-Tse Huang, Sung-Yuan Chen, Cheng-Hsuan Chen, Hsuan-Kai Kao

Subject: Engineering, Bioengineering Keywords: Intelligent Image Recognition; Left and Right Upper Limb Dislocation Surgery; Accuracy Rate; Recall Rate; IRB

Online: 5 September 2023 (09:20:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1375.v1

Enhancing Upper Limb Stroke Rehabilitation with Electromyography-Monitored Virtual Reality-Based Games

Zunaidi Ibrahim, Basri Noor Cahyadi, Azlan Aziz, Ahmad Shamil

Subject: Engineering, Control And Systems Engineering Keywords: Upper limb rehabilitation; VR Games Rehabilitation; Electromyography (EMG); Deltoid Muscle Recovery; Kinect Xbox; Control Rehabilitation

Online: 18 September 2024 (08:21:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0099.v1

Artificial Intelligent Image Recognition System for Preventing Wrong Side Upper Limb Surgery

Yi-Chao Wu, Chao-Yun Chang, Yu-Tse Huang, Sung-Yuan Chen, Cheng-Hsuan Chen, Hsuan-Kai Kao

Subject: Engineering, Bioengineering Keywords: Intelligent Image Recognition; Left and Right Upper Limb Dislocation Surgery; Accuracy Rate; Recall Rate; IRB

Online: 3 October 2023 (09:17:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1124.v1

A Scoping Review on Technology-Based Approaches for Upper Limb Motor Rehabilitation after Stroke. Are We Really Targeting Severe Impairment?

Emma Colamarino, Giovanni Morone, Jlenia Toppi, Angela Riccio, Febo Cincotti, Donatella Mattia, Floriana Pichiorri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: technological interventions; motor rehabilitation; upper limb; stroke; severe impairment; Exoskeleton; Neuroplasticity; Rehabilitation; Robotic training; Brain Computer Interfaces; Virtual Reality

Online: 15 August 2024 (06:28:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0051.v1

A Wearable Device for Upper Limb Rehabilitation and Assistance Based on Fluid Actuators and Myoelectric Control

Cristina-Maria Biriș, Sever-Gabriel Racz, Claudia-Emilia Gîrjob, Radu-Dumitru Grovu, Dan-Mihai Rusu

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: soft robotics, elastomer actuator, rehabilitation, wearable device, myoelectric control

Online: 1 August 2023 (10:27:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202111.0065.v1

Upper Limb Robotic Rehabilitation for Patients With Cervical Spinal Cord Injury: A Comprehensive Review

Giovanni Morone, Alessandro De Sire, Alex Martino Cinnera, Matteo Paci, Luca Perrero, Marco Invernizzi, Lorenzo Lippi, Marialuisa Gandolfi, Michela Agostini, Irene Aprile, Emanuela Casanova, Dario Marino, Giuseppe La Rosa, Federica Bressi, Silvia Sterzi, Daniele Giansanti, Alberto Battistini, Sandra Miccinilli, Serena Filoni, Monica Sicari, Salvatore Petrozzino, Claudio Marcello Solaro, Stefano Gargano, Paolo Benanti, Paolo Boldrini, Donatella Bonaiuti, Enrico Castelli, Francesco Draicchio, Vincenzo Falabella, Silvia Galeri, Francesca Gimigliano, Mauro Grigioni, Stefano Mazzoleni, Stefano Mazzon, Franco Molteni, Maurizio Petrarca, Alessandro Picelli, Federico Posteraro, Michele Senatore, Giuseppe Turchetti, Sofia Straudi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cervical spinal cord injury; Arm function; Exoskeleton; Robot-assisted therapy; Robotic therapy; Rehabilitation.

Online: 3 November 2021 (08:35:46 CET)

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The upper extremities limitation represents one of the essential functional impairments in patients with cervical spinal cord injury. Electromechanics assisted devices and robots are increasingly used in neurorehabilitation to help functional improvement in patients with neurological diseases. This review aimed to systematically report the evidence-based, state-of-art on clinical applications and robotic-assisted arm training (RAT) in motor and functional recovery in subjects affected by cervical spinal cord injury. The present study has been carried out within the framework of the Italian Consensus Conference on "Rehabilitation assisted by robotic and electromechanical devices for persons with disability of neurological origin" (CICERONE). PubMed/MEDLINE, Cochrane Library, and Physiotherapy Evidence Database (PEDro) databases were systematically searched from inception to September 2021. The 10-item PEDro scale assessed the study quality for the RCT and the AMSTAR-2 for the systematic review. Two different authors rated the studies included in this review. If consensus was not achieved after discussion, a third reviewer was interrogated. The 5-item Oxford CEBM scale was used to rate the level of evidence. A total of 11 studies were included. The selected studies were: two systematic reviews, two RCTs, one parallel-group controlled trial, one longitudinal intervention study and five case series. One RCT was scored as a high-quality study, while the systematic review was of low quality. RAT was reported as feasible and safe. Initial positive effects of RAT were found for arm function and quality of movement in addition to conventional therapy. The high clinical heterogeneity of treatment programs and the variety of robot devices could severely affect the generalizability of the study results; therefore, future studies are warranted to standardize the type of intervention and evaluate the role of robotic-assisted training in subjects affected by cervical spinal cord injury.

Preprint ARTICLE | doi:10.20944/preprints202402.0744.v1

A Rapid Control Prototyping and Hardware-in-the Loop Approach for Upper Limb Robotic Exoskeletons Control

Giulia Bodo, Federico Tessari, Stefano Buccelli, Matteo Laffranchi

Subject: Engineering, Control And Systems Engineering Keywords: Rehabilitative Robotics; Compliant actuation; Robotic Control; Upper Limb Exoskeleton; Rapid Control Prototyping

Online: 13 February 2024 (12:26:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0643.v1

Effects of Training and Calibration Data on Surface Electro-Myogram-Based Recognition for Upper Limb Amputees

Pan Yao, Kaifeng Wang, Weiwei Xia, Yusen Guo, Tiezhu Liu, Mengdi Han, Guangyang Gou, Chunxiu Liu, Ning Xue

Subject: Engineering, Bioengineering Keywords: surface electromyogram; cross-session gesture recognition; model calibration; amputee; intelligent prostheses

Online: 8 December 2023 (16:10:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0160.v1

Methodology for the Design of Rehabilitation Robots: Application in an Exoskeleton for Upper Limb Rehabilitation

Giorgio Mackenzie Cruz Martinez, Luis Adrian Zuñiga Aviles

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: methodology; exoskeleton; upper limb rehabilitation; design; digital twin

Online: 14 June 2020 (03:27:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1878.v1

New Design Options for Container Barges with Improved Navigability on the Danube

Bianca Duldner-Borca, Laura Hoerandner, Bernhard Bieringer, Reza Khanbilverdi, Lisa-Maria Putz-Egger

Subject: Engineering, Transportation Science And Technology Keywords: barge design; navigability; low water level; container transport; naval architecture; CAD; Danube

Online: 1 April 2024 (07:26:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0021.v1

Robot-Assisted Therapy Influence on Kinematic and EMG Activity in the Upper Limb for Children with Cerebral Palsy

Sana Raouafi, Maxime Raison, Sofiane Achiche

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: cerebral palsy; robot assisted therapy; EMG; kinematic

Online: 3 January 2020 (02:38:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0311.v1

Feasibility and Usability Study of a Robot-Assisted Complex Upper and Lower Limb Rehabilitation System in Patients with Stroke

Kyoung Tae Kim, Yongmin Choi, Jang Hyuk Cho, Soyoung Lee

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: robot-assisted gait training; rehabilitation; stroke; cardiorespiratory fitness; robotics; disability; locomotion

Online: 23 March 2022 (08:40:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0915.v1

Exploring Methodological Issues in Mental Practice for Post-stroke Paralytic Lateral Upper Limb Function: A Scoping Review

Akira Nakashima, Ryohei Okamura, Takefumi Moriuchi, Kengo Fujiwara, Toshio Higashi, Kounosuke Tomori

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Mental practice; stroke; upper limb function; methodology

Online: 12 January 2024 (04:00:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0355.v1

Neck Muscle Vibration Alters Upper Limb Proprioception as Demonstrated by Changes in Accuracy and Precision During an Elbow Repositioning Task

Hailey Tabbert, Ushani Ambalavanar, Bernadette Murphy

Subject: Social Sciences, Behavior Sciences Keywords: Neck Muscle Vibration; Proprioception; Body Schema

Online: 23 September 2022 (03:45:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1479.v1

Diagnosis of Chronic Granulomatous Disease: Strengths and Challenges in the Genomic Era

Conor John O’Donovan, Lay Teng Tan, Mohd Azri Zainal Abidin, Marion Ruth Roderick, Alexandros Grammatikos, Jolanta Bernatoniene

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Inborn errors of immunity (IEI); Chronic granulomatous disease (CGD); NADPH oxidase; Nitroblue tetrazolium (NBT); Dihydrorhodamine (DHR); Genetic testing; Genomic testing; Screening

Online: 18 July 2024 (14:38:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0089.v1

Evgeny Blagovechtchenski, Maria Koriakina, Dimitri Bredikhin, Olga Agranovich, Dzerassa Kadieva, Evgenia Ermolovich, Iiro P Jääskeläinen, Anna N Shestakova

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cognitive function; arthrogryposis; obstetrics palsy; children; motor disorder

Online: 6 December 2022 (02:31:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1071.v1

Error-enhancement for upper limb rehabilitation in the chronic phase after stroke: a 5-day pre-post intervention study

Marjan Coremans, Eli Carmeli, Ineke De Bauw, Bea Essers, Robin Lemmens, Geert Verheyden

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: stroke; upper limb rehabilitation; error-enhancement

Online: 14 December 2023 (10:44:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.1050.v1

The Role of Chemerin in Upper Gastrointestinal Cancer

Adam Mylonakis, Maximos Frountzas, Irene Lidoriki, Alexandros Kozadinos, Areti Kalfoutzou, Eva Karanikki, Ilianna Tsikrikou, Maria Kyriakidou, Dimitrios Theodorou, Konstantinos G. Toutouzas, Dimitrios Schizas

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Chemerin; Gastric cancer; Esophageal cancer; Obesity; Biomarker

Online: 13 September 2024 (04:30:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0050.v1

Enhancing Upper Limb Functionality, Gross and Fine Motor Skills, Autonomy, and Quality of Life in Acute Stroke Patients: A Mirror Therapy, Cognitive Therapeutic Exercise, and Task-Oriented Training

Jessica Fernández-Solana, Rodrigo Vélez-Santamaría, Adrián Moreno-Villanueva, Sergio Álvarez-Pardo, Jerónimo J. González-Bernal, Mirian Santamaría-Peláez, Josefa González-Santos

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: mirror therapy; cognitive therapeutic exercise; task-oriented training; upper limb; gross notor; fine motor; autonomy; quality of life; acute stroke

Online: 1 February 2024 (13:50:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1694.v1

Impact of Shaking Exercise on Functional Recovery in Patients with Chronic Post-Stroke Upper Limb Paralysis: A Multicenter, Open-Label, Quasi-Randomized Controlled Trial

Takuya Hada, Toyohiro Hamaguchi, Masahiro Abo

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: stroke rehabilitation; upper limb paralysis; home-based training; self-training device; botulinum toxin type A

Online: 27 May 2024 (07:50:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0368.v1

Application of Low-Intensity Modified Constraint-Induced Movement Therapy to Improve the Affecter Upper Limb Functionality in Infantile Hemiplegia with Moderate Manual Ability. Case Series

Rocío Palomo-Carrión, Rita-Pilar Romero-Galisteo, Elena Piñero-Pinto, Purificación López-Muñoz, Helena Romay-Barrero, Francisco García-Muro

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: family; infantile hemiplegia; modified Constraint-Induced Movement Therapy; Physical Therapy modalities; upper extremity.

Online: 17 July 2020 (08:04:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0357.v1

Characterization of Fermented Grains in the Upper and Lower Layers during NongXiangXing Baijiu Fermentation

Jie Deng, Zhiqiang Ren, Chaojiu He, Chunhui Wei, Jun Xie, Zhiguo Huang

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Baijiu; solid-state fermentation; microbial diversity; volatile compounds

Online: 4 September 2024 (11:25:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0025.v1

A Protocol for Identifying Potentially Repurposable Drugs Using Online Tools and Databases

Aditi Chattopadhyay, Madhavi Ganapathiraju

Subject: Medicine And Pharmacology, Other Keywords: drug repurposing; translational bioinformatics; transcriptomics; transcriptome analysis; drug discovery; protocol; gene expression

Online: 9 October 2016 (08:42:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1664.v1

Limb Salvage and Survival in Chronic Limb-Threatening Ischemia: The Need for Fast-Track Team-Based Approach

Giorgio Ventoruzzo, Giulia Mazzitelli, Umberto Ruzzi, Francesco Liistro, Alessia Scatena, Eugenio Martelli

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: peripheral arterial disease; critical limb ischemia; chronic limb-threatening ischemia; survival; mortality; limb salvage

Online: 25 August 2023 (02:41:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1523.v1

Accurate Calculation of Upper Biomass Volume of Single Trees Using Matrixial Representation of LiDAR Data

Fayez Tarsha Kurdi, Elżbieta Lewandowicz, Zahra Gharineiat, Jie Shan

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: LiDAR; tree modeling; upper biomass; tree crown; tree trunk; point cloud

Online: 23 April 2024 (17:23:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0268.v1

Extensive Limb Lengthening for Achondroplasia and Hypochondroplasia

Dror Paley

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: achondroplasia; hypochondroplasia; dwarfism; short-limb; short stature; FGFR3; skeletal dysplasia; genetic condition; extensive limb lengthening

Online: 12 May 2021 (11:22:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1715.v1

Percutaneous Deep Venous Arterialization for Limb Salvage of No Option Patients with Chronic Limb-Threatening Ischemia

Stavros Spiliopoulos, Efstathia Davoutis, Nikolaos-Achilleas Arkoudis, Kaji Sritharan, Symeon Lechareas

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic limb-threatening ischemia; peripheral arterial disease; endovascular treatment; tibial vessels; percutaneous deep venous arterialization

Online: 26 September 2023 (04:44:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0018.v1

Restoring Upper Limb Function by Combined Repetitive Transcranial Magnetic Stimulation and Occupational Therapy in Patients with Chronic Stroke: A Stratified Analysis Factoring the Severity of Motor Paralysis using a Multicenter Cohort Study Database

Daigo Sakamoto, Toyohiro Hamaguchi, Kai Murata, Hiroshi Ito, Yasuhide Nakayama, Masahiro Abo

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: stroke; occupational therapy; activities of daily living; goal setting; transcranial magnetic stimulation: upper extremity; motor paralysis

Online: 1 November 2022 (04:46:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1804.v1

The Effect of Lower Limb Combined Neuromuscular Electrical Stimulation on Skeletal Muscle Cross-sectional Area and Inflammatory Signaling

Amal Alharbi, Jia Li, Erika Womack, Matthew Farrow, Ceren Yarar-Fisher

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Spinal Cord Injury; Neuromuscular Electrical Stimulation; Inflammatory Signaling; Muscle Cross-Sectional Area; Myofiber Adaptation

Online: 28 April 2024 (08:02:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0049.v1

Optimization of Maize-Vegetable (Okra and Roselle) Intercrops in Northern, Upper West and Upper East Regions of Ghana

Jean Baptiste S. Tignegre, Abdul Rahman Nurudeen, Paul Alhassan Zaato, Asamoah Larbi, Albert Rouamba, Takemore Chagomoka, Fred Kiziito

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: maize; okra; roselle; intercrops; sole crop; land equivalent ratios; productivity

Online: 6 October 2022 (06:20:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0827.v1

Assessing the Impact of Climate Change on Food Security in Northern Ghana: Causes and Coping Strategies in the Upper East Region

Gifty Akapule, Abdul-wahab Tahiru, Patrick Tandoh-offin, Helene Garti

Subject: Environmental And Earth Sciences, Environmental Science Keywords: climate change; food security; Ghana; consumption

Online: 10 September 2024 (15:12:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0062.v1

Crustal and Upper Mantle Density Structure Beneath the Qinghai-Tibet Plateau and Its Surrounding Areas Derived from EGM2008 Geoid Anomalies

Honglei Li, Jian Fang

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Qinghai-Tibet Plateau; geoid anomaly inversion; crustal and upper mantle density construction

Online: 15 October 2016 (08:25:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0230.v1

Definition of a Multi-omics Signature for Esophageal Adenocarcinoma Prognosis Prediction

Luca Lambroia, Carola Conca Dioguardi, Simone Puccio, Andrea Pansa, Giorgia Alvisi, Gianluca Basso, Javier Cibella, Federico S. Colombo, Salvatore Marano, Silvia Basato, Rita Alfieri, Simone Giudici, Carlo Castoro, Clelia Peano

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Esophageal-Adenocarcinoma; Cancer; immunotherapy; treatment; single-cell RNA; single-cell sequencing; RNA sequencing; transcriptional signature; response to therapy; immune infiltrate.

Online: 3 July 2024 (00:25:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0986.v1

Towards a Remote Patient Monitoring Platform for Comprehensive Risk Evaluation for People with Diabetic Foot Ulcers

Gozde Cay, M.G. Finco, Jason Garcia, Jill L. McNitt-Gray, David G. Armstrong, Bijan Najafi

Subject: Engineering, Bioengineering Keywords: smart offloading; diabetes; diabetic foot ulcer; telemedicine; digital health; remote patient monitoring; personalized care

Online: 15 April 2024 (13:45:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1739.v1

Fasting Triglycerides in the Upper Normal Range Are Independently Associated with an Increased Risk of Diabetes Mortality

Yutang Wang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: triglyceride; diabetes; hypertension; cardiovascular disease; survival

Online: 29 February 2024 (12:53:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0486.v1

Same Organ, Two Cancers: Complete Analysis of Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas

Sorin Vamesu, Oana Andreea Ursica, Serban Eduard Milea, Mariana Deacu, Mariana Aşchie, Anca Florentina Mitroi, Voinea Felix, Mihaela Butcaru Pundiche, Cristian Ionut Orasanu, Raluca Ioana Voda

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: renal cell carcinoma, upper tract urothelial carcinoma, perineural invasion, risk factor, hematuria

Online: 7 June 2024 (10:55:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1341.v1

Mine Productivity Upper Bounds and Truck Dispatch Rules

Adriano Chaves Lisboa, Felipe Luz Barbosa Castro, Pedro Vinícius Almeida Borges de Venâncio

Subject: Engineering, Mining And Mineral Processing Keywords: mine productivity; upper bound; truck dispatch rule

Online: 23 October 2023 (05:42:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1449.v1

Evaluation of Physical and Mental Health in Adults Who Underwent Limb-Lengthening Procedures with Circular External Fixators during Childhood or Adolescence

Alessandro Depaoli, Marina Magnani, Agnese Casamenti, Marco Ramella, Grazia Chiara Menozzi, Giovanni Gallone, Marianna Viotto, Gino Rocca, Giovanni Trisolino

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: limb lengthening; Ilizarov; external fixation; congenital; pediatric; Patient-Reported Outcomes; Short Form 36; Stanmore Limb Reconstruction Score

Online: 20 August 2024 (12:35:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0506.v1

Upper Back Distinguishing Work-Related Musculoskeletal Problems among Quay and Rubber Tyred Gantry Crane Operators Working in Deep-Sea Port

Teerayut Sa-ngiamsak, Anamai Thetkathuek

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: port crane operators; quay crane; rubber tyred gantry crane; work-related musculoskeletal problem; perceived discomfort

Online: 8 May 2024 (14:03:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0617.v1

Upper and Lower Bounds to Pull-Out Loading of Inclined Hooked End Steel Fibres Embedded in Concrete

David W. A. Rees, Sadoon Abdallah

Subject: Engineering, Civil Engineering Keywords: Hooked-end fibre; SFRC; pull-out bounds; transverse isotropy; fibre orientation

Online: 11 June 2024 (08:17:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0347.v1

Energy and Information Fluxes at Upper Ocean Density Fronts

Pablo Cornejo, Adolfo Bahamondes

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: Submesoscale; Turbulence; Frontogenesis; Energy cascade; Mutual communication; Ocean density fronts

Online: 18 November 2022 (03:21:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0415.v1

Current Trends and Confounding Factors in Myoelectric Control: Limb Position and Contraction Intensity

Evan Campbell, Angkoon Phinyomark, Erik Scheme

Subject: Medicine And Pharmacology, Other Keywords: electromyography; EMG; feature extraction; feature selection; myoelectric control; classification; pattern recognition; prosthetics; wearables; amputee

Online: 28 February 2020 (02:09:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.0175.v1

Review and Analysis of Platform-Related Performance of Rehabilitation Lower Limb Exoskeletons

Hossein Karami, Stefano Maludrottu, Christian Vassallo, Matteo Laffranchi, Lorenzo De Michieli

Subject: Engineering, Bioengineering Keywords: Powered lower limb exoskeletons; rehabilitation and assistance; performance criteria; neurological disorders; auxiliary devices; control strategies; effectiveness of PLLE

Online: 2 August 2023 (10:04:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0011.v1

Soft Smart Garments for Lower Limb Joint Position Analysis

Massimo Totaro, Alessio Mondini, Chiara Lucarotti, Tommaso Poliero, Giovanni Cairoli, Jesus Ortiz, Lucia Beccai

Subject: Engineering, Electrical And Electronic Engineering Keywords: wearable system; strain sensor; bending; soft tactile sensor; textile; capacitive sensor; exoskeleton; human motion monitoring

Online: 5 September 2017 (03:44:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0754.v1

Diversity, Regeneration Potential, and Natural Restoration of Miombo along an Anthropization Gradient in the Rural Area of Lubumbashi (Upper-Katanga, D.R. Congo)

Dieu-donné Nghonda N’tambwe, Héritier Muteya Khoji, Waselin Salomon, Fidèle Mushagalusa Cuma, François Malaisse, Quentin Ponette, Yannick Sikuzani Useni, Wilfried Kalenga Masengo, Jan Bogaert

Subject: Environmental And Earth Sciences, Ecology Keywords: Anthropogenic pressure; deforestation; forest degradation; floristic diversity; natural regeneration; miombo woodlands.

Online: 12 June 2024 (04:41:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1863.v1

Adjoint Solver-Based Analysis of Mouth-Tongue Morphologies on Vapor Deposition in the Upper Airway

Mohamed Talaat, Xiuhua Si, Jinxiang Xi

Subject: Engineering, Bioengineering Keywords: morphological effect; adjoint solver; shape sensitivity; computational fluid dynamics (CFD); mu-cus-tissue layer; vapor transport; wall absorption; Acetaldehyde; Benzene

Online: 29 March 2024 (13:16:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0137.v1

Upper and Lower H^m Estimates for Solutions to Dissipative Systems

Robert Guterres, César Niche, Cilon Perusato, Paulo Zingano

Subject: Computer Science And Mathematics, Analysis Keywords: dissipative systems; upper and lower estimates; decay estimates; monotonicity method

Online: 8 July 2022 (10:13:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1538.v1

Limb Temperature Observations in the Stratosphere and Mesosphere Derived From the OMPS Sensor

Pedro Da Costa Louro, Philippe Keckhut, Alain Hauchecorne, Mustapha Meftah, Glen Jaross, Antoine Mangin

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Limb observations; stratosphere; mesosphere; temperature; OMPS; Cubesat; Observations

Online: 21 August 2024 (09:37:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0003.v1

Examination of Lower Limb Microcirculation in Diabetic Patients With and Without Intermittent Claudication

Katalin Biró, Barbara Sándor, Kinga Tótsimon, Katalin Koltai, Krisztina Fendrik, Dóra Endrei, Judit Vekasi, Kalman Toth, Gábor Késmárky

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: diabetes mellitus; lower extremity artery disease; red blood cell aggregation, transcutaneous partial tissue oxygen pressure

Online: 1 June 2023 (02:41:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0084.v1

Evaluation of a New Simplified Approach for Upper Superficial Impacted Wisdom Teeth Extraction. A Retrospective Split-Mouth Clinical Study

Alberto Materni, Karol Alí Apaza Alccayhuaman, Alberto Maltagliati, Daniele Botticelli, Stefano Benedicenti

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: third molar extraction; impacted tooth; flap design; oral surgery; maxillofacial surgery; glue; cyanoacrylate

Online: 4 March 2024 (02:46:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2316.v1

Innovation in Skills and Sustainable Development in Italian Upper Secondary Technical Education and the Professional Role of Construction, Environment, and Territory Technicians

Andrea Pompigna, Gianluigi Ferrario

Subject: Social Sciences, Education Keywords: Education for Sustainable Development (ESD); Technical and Vocational Education; Curriculum Innovation; Professional Competencies; Sustainable Mobility

Online: 30 July 2024 (00:14:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1133.v1

Upper Bound Limit Analysis of Deep Tunnel Face Support Pressure with Nonlinear Failure Criterion under Pore Water Conditions

Zihan Yang, Yongxin Li, Jingshu Xu

Subject: Engineering, Civil Engineering Keywords: ; deep tunnel face; pore water pressure; nonlinear failure criterion; upper bound theorem; failure mechanism; numerical simulation ;

Online: 15 July 2024 (07:51:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0145.v4

Gilbreath Equation, Gilbreath Polynomials, Upper and Lower Bound for Gilbreath Conjecture

Riccardo Gatti

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Gilbreath conjecture; Gilbreath sequence; Gilbreath equation; integer sequence; prime numbers; number theory

Online: 21 February 2023 (14:30:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0152.v1

Lower and Upper Bounds for Some Degree-Based Indices of Graphs

Gul Ozkan Kizilirmak, Emre Sevgi, Serife Buyukkose, Ismail Naci Cangul

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: graph; topological graph index

Online: 8 November 2022 (10:20:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0512.v1

Objective and Subjective Evaluation of a Passive Exoskeleton for Upper Limbs

Berenger Le Tellier, Thomas Albouy, Kevin Lebel

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: MSDs; exoskeleton; upper limb assistance; EMG; balance test; subjective questionnaire

Online: 26 November 2021 (18:09:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0741.v1

Inter-Limb Asymmetry in Female Sepak Takraw Players: An Observational Study

Htet Zayar, Christopher Mawhinney, Kornkit Chaijenkij

Subject: Physical Sciences, Other Keywords: between-limb differences; limb dominance; jump landing; kappa coefficient

Online: 11 June 2024 (14:28:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1198.v1

Reflections on Endogenous Biological Drivers in Diabetic Lower Limb Wounds Recurrence

Jorge Berlanga-Acosta, Ariana Garcia-Ojalvo, Gerardo Guillen-Nieto, Marta Ayala-Avila

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetic foot ulcer; ulcer remission; ulcer recurrence; ulcer relapse; diabetic complications; metabolic memory

Online: 29 April 2023 (03:39:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0514.v1

Barefoot vs Shod Running: An Analysis of Lower Limb Joint Forces

James Paxton, Graham Arnold, Sadiq Nasir, Weijie Wang, Rami Abboud

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Running; Joint force; Barefoot; Osteoarthritis; Injury

Online: 28 November 2022 (10:53:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1734.v1

Metabolic and Transcriptional Analysis Reveals Flavonoid Involvement in the Drought Stress Response of Mulberry Leaves

Guo Chen, Dong Li, Pei Yao, Fengyao Chen, Jianglian Yuan, Bi Ma, Zhen Yang, Biyue Ding, Ningjia He

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: drought stress; mulberry; flavonoids biosynthesis; diversified utilization

Online: 27 May 2024 (10:33:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0048.v1

Increased Corticospinal Excitability and Muscular Activity in a Lower Limb Reaction Task under Psychological Pressure

Yoshifumi Tanaka, Tatsunori Shimo

Subject: Social Sciences, Behavior Sciences Keywords: stress; transcranial magnetic stimulation; spinal reflex; reaction time; co-contraction

Online: 10 April 2017 (05:59:46 CEST)

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Working Paper ARTICLE

Visual Biofeedback Tool for Quantitative Pressure Monitoring in Lower-Limb Prosthetic Sockets

Shruti Turner, Shivali Jain, Akhil Patel, Matthew O Hopkins, Alison H McGregor

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: prosthetics; prosthetic socket; prosthetic socket fitting; biofeedback; rehabilitation; amputation

Online: 6 October 2021 (12:58:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0193.v1

Current Status of Cell-Based Therapy in Patients with Critical Limb Ischemia

Frantisek Jaluvka, Peter Ihnat, Juraj Madaric, Vaclav Prochazka

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Cell therapy, Peripheral arterial disease, Bone marrow, Adipose tissue, Mesenchymal stem cells, Exosome, Critical limb ischemia.

Online: 4 November 2020 (12:37:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0149.v1

Motion Intention Estimation for Active Power-Assist Lower Limb Exoskeleton Robot (APAL)

Mantian Li, Jing Deng, Fusheng Zha, Shiyin Qiu, Xin Wang

Subject: Engineering, Mechanical Engineering Keywords: motion intention estimation; active power-assist; exoskeleton robot; inverse dynamics

Online: 11 June 2018 (10:08:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0288.v1

SailBuoy Ocean Currents:Low Cost Upper Layer Ocean Current Measurements

Nellie Wullenweber, Lars Robert Hole, Peygham Ghaffari, Inger Graves, Harald Tholo, Lionel Camus

Subject: Environmental And Earth Sciences, Oceanography Keywords: SailBuoy; ADCP; Ocean current; Observation

Online: 21 June 2022 (05:33:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1558.v1

Serum Calcium Levels Approaching the Upper Limit of Normal Can Predict Prostate Cancer Relapse to the Bone and Beyond in Patients Managed with Radiotherapy: Mature Data at 10 Years

Zsolt Fekete, Patricia Ignat, Henrietta Jakab, Nicolae Todor, István Péter László, Alina-Simona Muntean, Sebastian Curcean, Adina Nemeș, Dumitrița Nuțu, Gabriel Kacsó

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: serum calcium; prostate cancer; follow-up; tumor markers; early intervention; prognostic factors; predictive factors; metastases

Online: 25 April 2024 (08:39:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1849.v1

Restless Sleep Disorder and Periodic Limb Movements During Sleep in Children with a History of Prematurity

Lourdes M. DelRosso, Hovig Artinian, Maria P. Mogavero, Oliviero Bruni, Raffaele Ferri

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: restless sleep disorder; periodic leg movements during sleep; prematurity; iron deficiency

Online: 28 August 2023 (10:29:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201901.0293.v1

The Homuncular Jigsaw: Investigations of Phantom Limb and Body Awareness Following Brachial Plexus Block or Avulsion

Mariella Pazzaglia, Erik Leemhuis, Anna Maria Giannini, Patrick Haggard

Subject: Social Sciences, Behavior Sciences Keywords: phantom limb, somatotopy, brachial plexus, deafferentation rehabilitation, anesthetic block.

Online: 29 January 2019 (09:46:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0486.v1

Endoscopic and Histopathological Findings in the Upper Gastrointestinal Tract in Pediatric Chron’s Disease

Dunja Putniković, Jovan Jevtić, Nina Ristić, Ivan D Milovanovich, Miloš Đuknić, Milica Radusinović, Nevena Popovac, Irena Đorđić, Zoran Leković, Radmila M Janković

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Crohn’ s, granuloma; endoscopy; esophagogastroduodenoscopy; colonoscopy; histopathology

Online: 8 March 2024 (04:09:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0365.v1

Neurological outcome and respiratory insufficiency in intramedullary tumors of the upper cervical spine

Kateryna Goloshchapova, Maria Goldberg, Bernhard Meyer, Maria Wostrack, Vicki Marie Butenschoen

Subject: Medicine And Pharmacology, Surgery Keywords: Intramedullary spinal cord tumours (IMSCT), upper cervical spine, neurological deterioration, respiratory insufficiency

Online: 6 July 2023 (07:45:05 CEST)

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Background and Objectives: Intramedullary spinal cord tumors (IMSCT) are rare entities. Especially, a location in the upper cervical spine as a highly eloquent region carries the risk of postoperative neurological deficits, such as tetraparesis or respiratory dysfunction. Evidence for respiratory dysfunction is scarce. The aim of this study was to describe the early and late postoperative clinical course of this highly eloquent tumours. Patients and Methods: This is a single-centre retrospective cohort study. We included 35 patients with IMSCT at levels of craniocervical junction to C4 who underwent surgical treatment between January 2008 and December 2022. The authors analysed the patients' preoperative status, tumour- and surgery-specific characteristics, and follow-up functional status. Results: The study cohort included 22 patients with grade II ependymoma (62.9%), 2 low-grade astrocytomas (5.7%), 2 glioblastomas (5.7%), 6 hemangioblastomas (17.1%), 2 metastases (5.7%), and 1 patient with partially intramedullary schwannoma (2.9%). Gross total resection was achieved in 76% of patients. Early dorsal column related symptoms and motor deterioration occurred in 64% and 44% of patients, respectively. At a follow-up of 3.27 ± 3.83 years, 43% and 33% of patients preserved postoperative sensory and motor deterioration, respectively. The median McCormick Scale grade was 2 in the preoperative and late postoperative periods, respectively (p=0.0897, α=0.05). Only two out of 35 patients (5.7%) developed new intermittent respiratory dysfunction, of whom two were transient. There were no surgery-related deaths. Conclusions: The surgery of IMSCT of the upper cervical spine could be performed without major procedure-related risk. Roughly a half of the patients develop new neurological deficit in the immediate postoperative period. However, most of the patients still maintain functional independence. The rate of respiratory insufficiency is low and is strongly influenced by the rapid neurological deterioration in high-grade tumours.

Preprint ARTICLE | doi:10.20944/preprints202010.0476.v1

Morphotectonic Analysis of the Upper Guajira, Colombia. A GIS and Remote Sensing Approach

Juan David Solano Acosta, Ana Ibis Despaigne Diaz, Jillian Pearse

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Remote sensing; Morphotectonic analysis; Lineaments; Riedel shear model; Upper Guajira; Caribbean plate

Online: 23 October 2020 (09:51:51 CEST)

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This study uses Landsat 8 and Digital Elevation Models (DEM) to show the dominant orientations of digital lineaments and morphotectonic features between measured trends and the tectonic evolution of the Upper Guajira, Colombia, in the northernmost region of the South American plate. Data from Landsat-8 and hillshaded images of three Digital Elevation Model (DEM) images with different resolutions (SRTM: 90m, ASTER-GDEM: 30m and Alos-Palsar: 12.5m), were used for the extraction and mapping of morpholineaments, drainage network and morphological features. Lineaments were analyzed by means of north azimuth frequency, length, density distributions, lithological distributions and geochronological periods. Tectonic control was supported by using the digitized geological map created by the Colombian Geological Service (SGC). Lineaments and faults were analyzed through the interpretation of a Riedel shear model as a result of the transtensional/transpressional tectonic arrangement of the Caribbean and South American plates. The directional trends of lineaments and faults indicate two dominant directions: NE-SW and E-W. The azimuth distribution analysis of measured structures and drainage channels show similar trends, except for some differences in the predominant directions of some drainage channels. The similarity in the orientation of lineaments, faults and drainage system highlights the degree of control exerted by underlying structures on the surface geomorphological features. Drainage channel classification illustrates the morphological and neo-tectonic complexity of the region. The extracted lineaments were divided into five geochronological groups based on the main ages of host rock formations according to the Colombian Geological Service (SGC) geological map. From the Cretaceous onward, the lineament azimuth frequency rotates from a NE-SW trend to a prominent E-W direction, which resembles the translation that Caribbean plate has been undergoing since the Cretaceous. Our results confirm that Remote Sensing techniques are reliable and useful to study the morphotectonic of an area and can be applied to zones of difficult access.

Preprint ARTICLE | doi:10.20944/preprints202405.1007.v1

Development and Evaluation of a Solar Milk Pasteurizer for the Savanna Ecological Zone of West Africa

Iddrisu Ibrahim, Paul Tengey, Joseph Atia Ayariga, Junhuan Xu, Boakai K. Robertson, Olufemi S. Ajayi, James Owusu-Kwarteng

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: pasteurization; solar pasteurizer; milk treatment; coliform bacteria; pathogens

Online: 15 May 2024 (08:52:35 CEST)

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Solar pasteurization, as a means of treating milk in remote rural areas without electrical power, is based on using solar energy to thermally inactivate pathogenic microorganisms at temperatures below the boiling point to maintain or improve milk quality. A solar milk pasteurizer of flat‐plate water‐heating glass acting as the solar collector, connected to a stainless-steel cylindrical milk vat, was constructed and evaluated in Navrongo, in the tropical savanna zone of Ghana, West Africa. The novel approach taken in this project is to integrate the solar collection and heat exchanger into a single unit using materials and fabrication techniques readily available in the developing world. The vat comprises a 1.5 mm thick stainless steel cylindrical tank, a 2.2 cm wide hot water jacket, and an outer layer of 5.0 mm thick aluminium foil insulation. Hot water produced by the collector was used for pasteurizing milk. The optimum quantity of milk that this device could pasteurize under the study conditions was 8 L. The device could pasteurize raw milk to a maximum temperature of 74 °C at 14:00 h GMT. The ambient temperature during the pasteurization ranged from 30 °C to 43 °C. The microbial analysis before and after the pasteurization was done, and the result shows that the total bacteria count before pasteurization was 6.6x10⁶ log CFU/mL per unit volume, and the total bacteria count after pasteurization was 1.0x10² log CFU/mL. By acceptable standards, the total bacteria count after pasteurization is within a safe range for consumption, and coliform counts were negative. The solar milk pasteurization system is cost-effective. Hence, it is appropriate for milk producers in arid pastoral areas without electricity to adopt the solar pasteurizer as an alternative to firewood as a fuel source for milk pasteurization. This approach can potentially create a cottage industry that may also play a crucial role as a water treatment technology that will improve the health of rural populations.

Preprint ARTICLE | doi:10.20944/preprints202406.0367.v1

Upper Airway Alarmin Cytokine Expression in Asthma of Different Severities

Hazel Marriott, Marc Duchesne, Subhabrata Moitra, Isobel Okoye, Luke Gerla, Irvin Mayers, Jalal Moolji, Adil Adatia, Paige Lacy

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Nasal brushings; TSLP; IL-25; IL-33; cytokeratin-8; epithelial cells

Online: 6 June 2024 (11:47:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0239.v1

Upper-Bound General Circulation of the Ocean: a Theoretical Exposition

Hsien-Wang Ou

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: general ocean circulation; Sverdrup dynamics, potential vorticity homogenization; thermal/dynamical coupling; upper-bound circulation

Online: 14 September 2021 (12:32:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0686.v1

The Role of Biomaterials in Upper Digestive Tract Transoral Reconstruction

Raluca Grigore, Bogdan Popescu, Serban Vifor Gabriel Bertesteanu, Cornelia Nichita, Irina Doinita Oasa, Gloria Simona Munteanu, Alexandru Nicolaescu, Paula Luiza Bejenaru, Catrinel Beatrice Simion Antonie, Dragos Ene, Razvan Ene

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: malignant neoplasia; transoral reconstruction; polydimethyl siloxane; Ag nanoparticles; fatigue strenght; prosthesis

Online: 28 December 2020 (11:24:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1867.v1

Assessment of the Effectiveness of Vibration Therapy and Passive Rest on the Recovery of Muscular Strength and Plasma Lactate Levels in the Upper Limbs After Intense Anaerobic Exercise in Elite Boxers and Kickboxers

Wiesław Chwała, Wacław Mirek, Tadeusz Ambroży, Wojciech Wąsacz, Łukasz Rydzik

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: vibration therapy; passive rest; muscle recovery; lactate levels; isokinetic dynamometry

Online: 28 May 2024 (12:59:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1682.v1

Yield and Forage Characteristics of Winter Rye Cultivars for Use within the Upper Midwest

Julija A. Cubins, James O. Eckberg, Axel Garcia y Garcia, Gregg A. Johnson, Jochum Wiersma, Samantha Wells

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Winter rye; cereal rye; phenotypic diversity; biomass yield; forage quality

Online: 23 January 2024 (09:57:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1945.v1

Groundwater Level Trend Analysis and Prediction in the Upper Crocodile (West) Basin, South Africa

Tsholofelo Mmankwane Tladi, Julius Musyoka Ndambuki, Thomas Otieno Olwal, Sophia Sudi Rwanga

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Rainfall; Groundwater; Mann-Kendall; Upper Crocodile; Characterisation; Cross-correlation; Autocorrelation; lag time; Gradient Boosting; Machine Learning

Online: 29 May 2023 (02:19:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0567.v1

Establishment of a Sheep Model for Hind limb Peripheral Nerve Injury: Common Peroneal Nerve

Rui D. Alvites, Mariana V. Branquinho, Ana Catarina Sousa, Federica Zen, Monica Maurina, Stefania Raimondo, Carla Mendonça, Luís Miguel Atayde, Stefano Geuna, Artur S. P. Varejão, Ana Colette Maurício

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Peripheral Nerve Injury; Peripheral Nerve Regeneration; Peroneal Common Nerve; Animal Model; Sheep Model; Nerve Anatomy; Neurological Exam; Nerve Stereology

Online: 22 December 2020 (16:07:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0706.v1

Influence of Kinesio Tape on Lower Limb Muscular Activity after Knee Joint Rehabilitation Program

Hossam El-Gazzar, Abdel Basset Abdel gawad, Abdel-Rahman Akl

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Kinesio tape; injury-prevention; electromyography

Online: 30 July 2020 (07:44:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0104.v1

Comparative Distal Limb Anatomy Reveals a Primitive Trait in 2 Breeds of Equus caballus

Sharon May-Davis, Zefanja Vermeulen, Wendy Y. Brown

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: 2nd, 3rd, 4th interosseous muscle; Dutch Konik; Bosnian mountain horse; donkey; Przewalski; zebra; atavism

Online: 9 April 2019 (11:32:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1188.v1

Reappraisal of Duodenal Exclusions and Biliopancreatic Limb Length in Metabolic Surgery for Nonobese Patients with Type 2 Diabetes

Kyung Yul Hur

Subject: Medicine And Pharmacology, Surgery Keywords: metabolic surgery; type 2 diabetes; postoperative hyperglycemia; duodenal exclusion; biliopancreatic limb length; altered epithelial identity; GIP

Online: 19 September 2023 (03:49:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0678.v1

COVID-19 Vaccines for Optimizing Immunity in the Upper Respiratory Tract

Ranjan Ramasamy

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: adaptive immunity to COVID-19; clinical vaccine trials; COVID-19; COVID-19 vaccines; innate immunity to COVID-19; mucosal vaccines; nasal vaccines; SARS-CoV-2; upper respiratory tract immunity; vaccine safety

Online: 11 October 2023 (10:52:38 CEST)

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Working Paper HYPOTHESIS

Upper Limit on the Thermodynamic Information Content of an Action Potential

Sterling Street

Subject: Biology And Life Sciences, Biophysics Keywords: information; entropy; energy; thermodynamics; Landauer's principle; action potential

Online: 4 February 2020 (04:42:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0388.v1

Three-Dimensional Lower Limb Kinematics from Accelerometers and Gyroscopes with Simple and Minimal Functional Calibration Tasks: Validation on Asymptomatic Participants

Lena Carcreff, Gautier Grouvel, Gabriel Payen, Fabien Massé, Stéphane Armand

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: inertial measurement units; gait kinematics; lower limbs; tridimensional kinematics; clinical gait analysis

Online: 28 June 2022 (16:06:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2409.v1

Devising a Simple Evaluation Method for Assessing Motor Coordination in the Upper and Lower Limbs

Runjie Li, Chisato Yamamoto, Tetsuya Miyazaki, Tomoyuki Matsui, Megumi Gonno, Teruo Nomura, Kohei Okado, Masashi Ito, Toru Morihara, Noriyuki Kida

Subject: Biology And Life Sciences, Other Keywords: motor coordination of the upper and lower limbs; motor coordination training; simple evaluation method

Online: 30 July 2024 (10:32:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0215.v1

Geochemical and Mineralogical Features of Triassic Dolomites From the Area of Upper Silesia in Poland

Katarzyna J. Jadwiga Stanienda-Pilecki, Rafał Jendruś

Subject: Environmental And Earth Sciences, Geography Keywords: dolomites; microscopic analysis; X-Ray Diffraction; X-Ray Fluorescence; Electron microprobe analysis; geochemical properties

Online: 5 December 2023 (06:03:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1135.v1

A Feasibility Study of the RESP-8 Tool: Enhancing Pharmacist-Led Triage for Upper Respiratory Tract Infections

Eleftherios Teperikidis, Andreas Vitsos, Angeliki Kokkini, Maria Fesatidou, Sophia Apostolou, Anna Sidiropoulou, Dionysis Evgenidis, Eleftheria Ztriva, Athena Myrou, Georgia Kaiafa, Eleni Karlafti, Stylianos Daios, Thomas Tegos, Christos Savopoulos

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Upper respiratory tract infections, URTI, pharmacists, RESP-8 tool, medical evaluation, public health.

Online: 17 June 2024 (10:34:55 CEST)

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Background: Upper respiratory tract infections (URTIs) are a major public health concern due to their high incidence and potential for complications. Pharmacists often serve as the first point of contact for patients with URTIs. This study aims to develop and evaluate the RESP-8 tool to assist pharmacists in determining the need for medical evaluation. Methods: This prospective interventional cohort study was conducted over six months (October 2023 to March 2024) in community pharmacies. Participants included adults aged 18 years and older presenting with URTI symptoms. Pharmacists used the RESP-8 tool, which comprises eight criteria to assess the need for medical referral. Data on medical history, symptom duration, and progression were recorded. The primary outcome was the feasibility of implementing the RESP-8 tool. Secondary outcomes included the accuracy of the tool, the percentage of patients recommended for medical evaluation, and compliance with these recommendations. Results: A total of 64 participants were included, with an average age of 55.7 years. Pharmacists recommended medical evaluation for 75% (48/64) of patients using the RESP-8 tool. Among these, 70.83% (34/48) complied with the recommendation. The tool demonstrated high accuracy in identifying patients needing further medical evaluation, with only two noted errors. All compliant patients received appropriate treatment without complications. The tool was easy to implement, taking less than 5 minutes per patient. Discussion: The RESP-8 tool effectively guided pharmacists in recommending medical evaluations for URTI patients. The high compliance rate indicates patient trust in pharmacists' guidance. While the study's small sample size limits generalizability, the results are promising. Future studies with larger populations are necessary to validate these findings and further refine the tool. Conclusion: The RESP-8 tool shows potential in enhancing pharmacists' ability to make informed decisions about medical referrals for URTIs, ultimately improving patient outcomes and optimizing healthcare resource management.

Preprint ARTICLE | doi:10.20944/preprints202407.2520.v1

A Platform Technology for VR Biofeedback Training under Operant Conditioning for Functional Lower Limb Weakness

Anirban Dutta, Abhijit Das

Subject: Engineering, Bioengineering Keywords: functional neurological disorder; functional motor disorder; operant conditioning; sensory attenuation and amplification; functional near-infrared spectroscopy; electroencephalography

Online: 31 July 2024 (09:39:24 CEST)

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Functional neurological disorder (FND) is a complex condition that involves a disruption in the brain's ability to properly integrate sensory input and prior expectations, leading to motor dysfunction in functional motor disorders (FMD). This study investigates the role of sensory attenuation and the sense of agency in FMD, focusing on how these mechanisms can be leveraged for therapeutic interventions. Sensory attenuation, the brain's ability to predict and reduce the intensity of self-generated sensory inputs, is impaired in FMD, leading to a reduced sense of agency. This impairment disrupts motor control and contributes to the perception of involuntary movements.We propose using a bipedal reaching virtual reality (VR) task combined with a haptic ankle device to explore and potentially rehabilitate these impairments. In this task, foot positions are represented by VR objects, with initial weighting favoring the unaffected limb. This weighting gradually shifts to the affected limb as its involvement increases under operant conditioning. The task occasionally introduces perturbations to probe motor-related processing and feedback correction, providing a sensitive measure of visuomotor control. Additionally, we incorporate neuroimaging techniques, specifically functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), to monitor brain activity and assess the effectiveness of these interventions. This approach aims to enhance understanding of the neural mechanisms underlying FND and develop targeted therapies that improve motor control by leveraging the interplay between sensory attenuation and amplification.Our findings could provide valuable insights into the treatment of FND, emphasizing the importance of feedback modulation and the integration of modern technologies like VR and haptic feedback in therapeutic interventions. This research has the potential to significantly improve the prognosis and quality of life for individuals with FND.

Preprint ARTICLE | doi:10.20944/preprints202401.1593.v1

The Lower Limb Muscle Co-activation Map during Human Locomotion: From Slow Walking to Running.

Lorenzo Fiori, Stefano Filippo Castiglia, Giorgia Chini, Francesco Draicchio, Floriana Sacco, Mariano Serrao, Antonella Tatarelli, Tiwana Varrecchia, Alberto Ranavolo

Subject: Engineering, Bioengineering Keywords: Muscle coactivations, Walking, Running, Spinal map, sEMG

Online: 23 January 2024 (00:13:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1285.v1

Improving the Clinical Utility of Platelet Count in Primary Care with Age- and Sex-Stratified Upper Thresholds Suggestive of an Undiagnosed Cancer: A Cohort Study Set in Primary Care in England, Canada, and Australia

Luke T. A. Mounce, Raff Calitri, Willie Hamilton, Meena Rafiq, Jon D. Emery, Vasily Giannakeas, Joanne Kotsopoulos, Sarah E. R. Bailey

Subject: Public Health And Healthcare, Primary Health Care Keywords: cancer; diagnosis; primary care; family medicine; full blood count; platelet count

Online: 19 April 2024 (14:37:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2298.v1

The Effects of High-Intensity, Low-Duration and Low-Intensity, High-Duration Hamstrings Static Stretching on Contralateral Limb Performance

Emily Jodean Philpott, Mohammadmahdi Bahrami, Mahta Sardroodian, David George Behm

Subject: Other, Biology And Life Sciences Keywords: Range of motion; maximal voluntary isometric contraction; muscle activation; stretch tolerance; flexibility

Online: 29 July 2024 (11:48:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0390.v1

The Impact of Sciatic Nerve Injury on Extracellular Matrix of Lower Limb Muscle and Thoracolumbar Fascia: An Observational Study

Xiaoxiao Zhao, Caterina Fede, Lucia Petrelli, Carmelo Pirri, Elena Stocco, Chenglei Fan, Andrea Porzionato, Raffaele De Caro, Stefano Masiero, Carla Stecco

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: extracellular matrix; peripheral nerve injury; hyaluronan; collagen; intramuscular connective tissue; thoracolumbar fascia

Online: 4 July 2024 (05:58:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0110.v1

Assessing the Suitability of CHA2DS2-VASc for Predicting Adverse Limb Events and Cardiovascular Outcomes in Peripheral Artery Disease Patients

Yu-Tsung Cheng, Fu-Lan Chang, Po-Hsien Li, Wen-Chien Lu, Chien-Shan Chiu

Subject: Public Health And Healthcare, Other Keywords: Peripheral artery disease (PAD); modified cumulative risk (MCR) score; CHA2DS2-VASc; Major adverse cardiovascular events (MACE); Major adverse limb events (MALE); percutaneous coronary intervention (PCI)

Online: 2 May 2024 (09:41:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2040.v1

Recurrent Non-variceal Upper Gastrointestinal Bleeding among Patients Receiving Dual Antiplatelet Therapy

Ah Young Yoo, Moon Kyung Joo, Jong-Jae Park, Beom Jae Lee, Seung Han Kim, Won Shik Kim, Hoon Jai Chun

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: dual antiplatelet therapy; upper gastrointestinal tract; bleeding; mortality

Online: 30 August 2023 (07:19:06 CEST)

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