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Preprint ARTICLE | doi:10.20944/preprints202408.1291.v1

Development of Smallpox Antibody Testing and Surveillance Following Smallpox Vaccination in the Republic of Korea

Hwachul Shin, SangEun Lee, Myung-Min Choi, Hwajung Yi, Yoon-Seok Chung

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: smallpox; Vaccinia virus; smallpox vaccine; antibody titer; ELISA; bioterrorism

Online: 20 August 2024 (04:55:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0920.v1

The Diagnostic Challenge of Cystic Echinococcosis in Humans: First Assessment of Underreporting Rates in Mongolia

Bolor Bold, Christian Schindler, Uranshagai Narankhuu, Agiimaa Shagj, Erdenebileg Bavuujav, Sonin Sodov, Tsogbadrakh Nyamdorj, Jakob Zinsstag

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: cystic echinococcosis 1; Mongolia 2; clinical guideline 5; burden of disease 6; Echinococcus granulosus 6

Online: 13 June 2024 (14:54:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0033.v1

Establish and Apply a Safe and Convenient Pseudovirus-Based Assay to Detect Neutralizing Antibodies against Influenza A (H7N9) Virus

Li Zhang, Jing Lu, Jingxing Li, Rong Tang, Haiyan Peng, Fanyue Meng, Yuemei Hu

Subject: Biology And Life Sciences, Virology Keywords: H7N9 avian influenza; pseudovirus; neutralization assay; relative luminescence units (RLU)

Online: 6 January 2017 (10:21:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0030.v2

Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China

Chao Wang, Shuang Li, Tao Li, Shanfa Yu, Junming Dai, Xiaoman Liu, Xiaojun Zhu, Yuqing Ji, Jin Wang

Subject: Social Sciences, Psychology Keywords: occupational stress; job burden-capital model; structural equation model; depression; well-being

Online: 4 August 2016 (12:47:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0180.v1

The Distal Promoter of the B438L Gene of African Swine Fever Virus Is Responsible for the mRNA Transcription of the B438L and the Alternatively Spliced B169L

Hongwei Cao, Hao Deng, Yanjin Wang, Diqiu Liu, Lian-Feng Li, Meilin Li, Dingkun Peng, Jingwen Dai, Jiaqi Li, Hua-Ji Qiu, Su Li

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: African swine fever virus; B438L promoter; transcription initiation; B169L protein

Online: 3 May 2024 (09:46:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0026.v1

Molecular Prevalence, Genetic Diversity, and Tissue Tropism of Bartonella Species in Small Mammals from Yunnan Province, China

Pei-Yu Han, Fen-Hui Xu, Jia-Wei Tian, Jun-Ying Zhao, Ze Yang, Wei Kong, Bo Wang, Li-Jun Guo, Yun-Zhi Zhang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Bartonella; small mammals; genetic diversity; evolution; tissue tropism

Online: 1 April 2024 (17:07:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2546.v1

Dynamics of Mammarenavirus Wenzhouense Acute Infection in the Rodent Rattus norvegicus

ShanShan Du, XueFei Deng, Xiaoxia Huang, TieZhu Liu, Aqian Li, Qin Wang, TingTing Tian, Chuan Li, ZhangQi Zheng, QiHan Lin, ZhuoWei Li, Shiwen Wang, Jiandong Li

Subject: Public Health And Healthcare, Other Keywords: Wenzhou virus; acute infection; virus shedding, transmission; rodents; arenavirus

Online: 31 July 2024 (15:21:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0600.v1

Characterization of Avian Influenza Viruses Detected in Kenyan Live Bird Markets and Wild Bird Habitats Reveal Genetically Diverse Subtypes and High Proportion of A(H9N2), 2018-2020

Peninah Munyua, Eric Osoro, Joyce Jones, George Njogu, Genyan Yang, Elizabeth Hunsperger, Christine Szablewski, Ruth Njoroge, Doris Marwanga, Harry Oyas, Ben Andagalu, Romona Ndanyi, Nancy Otieno, Vincent Obanda, Carolyne Nasimiyu, Obadiah Njagi, Juliana DaSilva, Yunho Jang, John R Barnes, Gideon Emukule, Clayton Onyango, Charles Davis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Africa; surveillance; poultry diseases; avian influenza; low pathogenic

Online: 8 August 2024 (08:53:37 CEST)

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Following the detection of highly pathogenic avian influenza (HPAI) virus in countries bordering Kenya to the west, we conducted surveillance among domestic and wild birds along the shores of Lake Victoria. In addition, between 2018 and 2020, we conducted surveillance among poultry and poultry workers in live bird markets and among wild migratory birds in various lakes that are resting sites during migration to assess introduction and circulation of avian influenza viruses in these populations. We tested 7,464 specimens (oropharyngeal and cloacal swabs) from poultry and 6,531 fresh fecal specimens from wild birds for influenza A viruses by real-time RT-PCR. Influenza was detected in 3.9% (n=292) of specimens collected from poultry and 0.2% (n=10) of fecal specimens from wild birds. On hemagglutinin subtyping, most of the influenza A positives from poultry (274/292, 93.8%) were H9. Of 34 H9 specimens randomly selected for further subtyping, all were H9N2. On phylogenetic analysis, these viruses were genetically similar to other H9 viruses detected in East Africa. Only two of the ten influenza A positive specimens from the wild bird fecal specimens were successfully subtyped; sequencing analysis of one specimen collected in 2018 was identified as low pathogenicity avian influenza H5N2 virus of the Eurasian lineage and the second specimen, collected in 2020, was subtyped as H11. A total of 18 OP/NS swabs from poultry workers with ARI (12%) were collected; none were positive for influenza A virus. We observed significant circulation of H9N2 influenza viruses in poultry in live bird markets in Kenya. During the same period, low pathogenic H5N2 virus was detected in a fecal specimen collected in a site hosting a variety of migratory and resident birds. Although HPAI H5N8 was not detected in this survey, these results highlight the potential for introduction and establishment of highly pathogenic avian influenza viruses in poultry populations and the associated risk of spillover to human populations.

Preprint ARTICLE | doi:10.20944/preprints202406.1937.v1

Emergence of recombinant SARS-CoV-2 variants in California, 2020-2022

Rahil Ryder, Emily Smith, Deva Borthwick, Jesse Elder, Mayuri Panditrao, Christina Morales, Debra A. Wadford

Subject: Public Health And Healthcare, Other Keywords: SARS-CoV-2; genomic epidemiology; genomic surveillance; recombination; whole-genome sequencing; California COVIDNet

Online: 27 June 2024 (11:03:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2477.v1

Sublethal Sodium Hypochlorite Exposure: Impact on Resistance-Nodulation-cell Division (RND) Efflux Pump Overexpression, and Cross-Resistance to Imipenem

Ji-Hyun Nam, Jung Sik Yoo

Subject: Public Health And Healthcare, Primary Health Care Keywords: cross-resistance; imipenem antibiotics; NaOCl disinfectant; resistance-nodulation-cell division (RND) efflux pump

Online: 31 July 2024 (08:32:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0348.v1

Accuracy of Anti-SARS-CoV2 Antibody in Comparison with Surrogate Viral Neutralization Test in Person Living with HIV, Systemic Lupus Erythematosus and Chronic Kidney Disease

Marita Restie Tiara, Chrisan Bimo Prayuda, Tara Titian Maulidya, Hofiya Djauhari, Dadang Suhendar, Rudi Wisaksana, Laniyati Hamijoyo, Rudi Supriyadi, Agnes Rengga Indrati, Bachti Alisjahbana

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; vaccination; antibody; immunoassay; neutralization antibody

Online: 4 April 2024 (05:53:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0015.v1

Detection of Dengue Virus 1 and Mammalian Orthoreovirus 3, with Novel Reassortments, in a South African Family Returning from Thailand, 2017

Petrus Jansen van Vuren, Rhys H. Parry, Janusz T. Paweska

Subject: Biology And Life Sciences, Virology Keywords: dengue virus; mammalian orthoreovirus; MRV; imported infections; clinical metagenomics; metagenomics

Online: 1 August 2024 (11:13:04 CEST)

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In July 2017, a family of three members; a 46-year-old male, a 45-year-old female and their 8-year-old daughter, returned to South Africa from Thailand. They presented symptoms consistent with mosquito-borne diseases, including fever, headaches, severe body aches and nausea. Mosquito bites in all family members suggested recent exposure to arthropod-borne viruses. Dengue virus 1 (Genus Orthoflavivirus) was isolated (isolate no. SA397) from the serum of the 45-year-old female via intracerebral injection in neonatal mice and subsequent passage in VeroE6 cells. Phylogenetic analysis of this strain indicated close genetic identity with cosmopolitan genotype 1 DENV1 strains from Southeast Asia, assigned to major lineage K, minor lineage 1 (DENV1I_K.1), such as GZ8H (99.92%) collected in November 2018 from China and DV1I-TM19-74 isolate (99.72%) identified in Bangkok, Thailand, in 2019. Serum samples from the 46-year-old male yielded a virus isolate that could not be confirmed as DENV1, prompting unbiased metagenomic sequencing for virus identification and characterization. Illumina sequencing identified multiple segments of a Mammalian orthoreovirus (MRV), designated Human/SA395/SA/2017. Genomic and phylogenetic analysis classified Human/SA395/SA/2017 as MRV-3 and assigned a tentative genotype MRV-3d based on the S1 segment. Genomic analyses suggested Human/SA395/SA/2017 may have originated from reassortments of segments among swine, bat, and human MRVs. The closest identity of the viral attachment protein σ1 (S1) was related to a human isolate identified from Tahiti, French Polynesia, in 1960. This indicates ongoing circulation and cocirculation of Southeast Asian and Polynesian strains, but detailed knowledge is hampered by limited availability of genomic surveillance. This case represents a rare concurrent importation of two distinct viruses with different transmission routes in the same family with similar clinical presentations. It highlights the complexities of diagnosing diseases with similar sequelae in travellers returning from tropical areas.

Preprint COMMUNICATION | doi:10.20944/preprints202409.0501.v1

Prospect on Damage Control in Current ASD Intervention

Qi Zhang, Qiang Li

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism; Immune stress; Brain damage; Damage control

Online: 6 September 2024 (09:40:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1322.v1

Community Directed Vector Control to Accelerate Onchocerciasis Elimination

Benjamin Jacob, Edwin Michael, Thomas Raymond Unnasch

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Onchocerca volvulus; Simulium; river blindness; remote sensing; trap

Online: 22 February 2024 (16:10:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1729.v1

Immunogenicity Persistence of Different Immunization Regimens of Rabies Vaccine in the 10–60 Years Age Group: a Follow-up Report Based on Phase III Clinical Trial

Yunpeng Wang, Zhiang Wu, Jia Li, Shouchun Cao, Leitai Shi, Danhua Zhao, Zhaojun Mo, Haiyan Liang, Xiaohong Wu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: four-dose immunization regimen; five-dose immunization regimen; immunogenicity persistence; rabies; vaccine

Online: 23 August 2024 (12:08:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1151.v1

Whole-Genome Sequencing Analysis of Antimicrobial Resistance, Virulence Factors, and Genetic Diversity of Salmonella Isolated from Wenzhou, China

Yafang Jin, Yi Li, Shaojie Huang, Chengji Hong, Xucong Feng, Huidi Cai, Yanmei Xia, Shengkai Li, Leyi Zhang, Yongliang Lou, Wanchun Guan

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Salmonella; antimicrobial resistance; pathogenicity islands; cgMLST; Whole genome sequencing

Online: 16 September 2024 (03:20:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0192.v1

Correlating Quantitative and Genomic SARS-CoV-2 Wastewater Data with Clinical Metrics in Metropolitan Perth, Western Australia

Jake Gazeley, Terence Lee, Daniel R Knight, Alexander Shivarev, Cameron Gordon, David Speers, Dylan D Barth, Jelena Maticevic, Meredith Hodge, Paul Armstrong, Paul Knight, Sandra Sjollema, Avram Levy

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Wastewater-based epidemiology; SARS-CoV-2; COVID-19; surveillance system; correlation analysis; genomics

Online: 5 March 2024 (09:07:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1263.v1

Optimizing Traffic Flow Through Congestion Management at Peshawar Toll Plaza: A Data-Driven Approach

Adil Hussain, Muhammad Afzal, Tariq Tariq

Subject: Computer Science And Mathematics, Analysis Keywords: PTV Vissim; Toll Plaza optimization; Traffic flow; Toll-collecting effectiveness; Data analysis; Vehicle classifications; intelligent traffic management systems

Online: 20 June 2024 (10:46:17 CEST)

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Toll plaza optimization is essential for improving traffic flow and easing congestion on road networks. This study aims to suggest and assess potential optimization solutions for the Peshawar toll plaza, considering variables like traffic volume, toll-collecting effectiveness, and customer facilitation. Different resources are used for data collection, like the National Highway Authority of Pakistan. Physical data is collected from the established Toll Plaza of Peshawar, along with the development of each line. The goal of this study is to suggest and assess potential optimization solutions for the Peshawar toll plaza, considering variables like traffic volume, toll-collecting effectiveness, and customer happiness. The analysis of present traffic patterns, the detection of bottlenecks, and the creation of plans to ease congestion and enhance overall traffic flow are all part of the optimization process. The approaches used in this study include data analysis, simulation, and traffic modeling. PTV VISSIM is software for transportation planning, design, and analysis. The simulations consider various conditions, such as variable traffic volumes, toll collection methods, and lane configurations. When comparing the different optimization strategies, performance indicators like trip time, latency, and queue length are utilized to determine which approach is practical. Waiting time Vs. Existing each lane, etc, is explained. In the end, comparing queue lengths and throughput across different lane scenarios shows that maximizing throughput with existing lanes yields up to 45% improvement with E-tag lanes, 40% with existing E-tag lanes, 38% with E-tag plus additional toll and cash lanes, 32% with three cash lanes, and 28% with two E-tag lanes. Failure to regularly monitor and adjust the existing lane pattern scenario based on traffic patterns can lead to queues being 20% longer. Without proactive evaluation and optimization, there is a potential 63% opportunity for queue length improvement

Preprint ARTICLE | doi:10.20944/preprints202002.0153.v1

Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk

Dahmana Handi, Laurent Granjon, Christophe Diagne, Bernard Davoust, Florence Fenollar, Oleg Mediannikov

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Pathogens host; zoonotic disease; rodents; Bartonella; Borrelia crocidurae; Anaplasmataceae; Piroplasmida; Hepatozoon.

Online: 11 February 2020 (15:22:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1259.v1

An Overlooked Group of Citizen Scientists in NIS Information: Shell Collectors and Their Contribution to Molluscan NIS Diversity

Argyro Zenetos, Cristiane DELONGUEVILLE, Roland SCAILLET

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Alien species; Mediterranean Sea; mollusca; citizen science; amateur malacologists

Online: 18 April 2024 (12:30:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0351.v1

Efficacy and Immunogenicity of rKVAC85B in a BCG Prime-Boost Regimen Against H37Rv and HN878 Tuberculosis Strains

Eunkyung Shin, Jin-Seung Yun, Young-Ran Lee, Hye-Ran Cha, Soo-Min Kim, Sung-Jae Shin, Sang-Won Lee, Gyung Tae Chung, Dokeun Kim, Jung Sik Yoo, Jong-Seok Kim, Hye-Sook Jeong

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Mycobacterium tuberculosis; tuberculosis; vaccine; attenuated vaccinia virus; Antigen 85B; immunogenicity; bacterial loads

Online: 6 March 2024 (11:04:56 CET)

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Working Paper REVIEW

A Generalizable One Health Framework for the Control of Zoonotic Diseases

Ria Ghai, Ryan Wallace, James Kile, Trevor Shoemaker, Antonio Vieira, Maria Negron, Sean Shadomy, Julie Sinclair, Grace Goryoka, Stephanie Salyer, Casey Barton Behravesh

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: One Health; zoonotic disease; zoonotic disease control; anthrax; brucellosis; rabies; rift valley fever; zoonotic influenza

Online: 24 September 2021 (14:19:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0582.v1

Seroconversion and Kinetics of Vibriocidal Antibodies during the First 90 Days of Re-vaccination with Oral Cholera Vaccine in an Endemic Population

Caroline Cleopatra Chisenga, Bernard Phiri, Harriet Ngombe, Mutinta Muchimba, Kalo Musukuma, Suwilanji Silwamba, Natasha Makabilo Laban, Charlie Luchen, Fraser Liswaniso, Kennedy Chibesa, Cynthia Mubanga, Kapambwe Mwape, Michelo Simuyandi, Adam F. Cunningham, David A Sack, Samuel Bosomprah

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Vibrio Cholerae; Shanchol Vaccine; Immunogenicity; HIV; Waning; Cholera Priority Areas

Online: 9 February 2024 (11:38:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1723.v1

Effectiveness of Three Front-of-Pack Food Labels in Guiding Consumer Identification of Nutrients of Concern and Purchase Intentions in Kenya: A Randomized Controlled Trial

Shukri F Mohamed, Caroline H Karugu, Samuel Iddi, Veronica Ojiambo, Caliph Kirui, Gershim Asiki

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: front-of-pack-labels (FOPL); warning labels (WL); packaged foods; salt; sugar; saturated fats; fat; randomized controlled trial (RCT); Kenya ;

Online: 23 September 2024 (12:00:17 CEST)

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Background: Front-of-pack-labels (FOPLs) on packaged foods provide consumers with essential information about the nutritional content of food products, enabling them to make informed choices and align their dietary habits with their health goals. However, evidence on the comprehensibility, use, and effectiveness of FOPLs remains limited, particularly in low- and middle-income countries like Kenya. Objective: In this study, we assessed the effectiveness of three FOPLs in helping consumers identify excess nutrients of concern in packaged food products and their potential influence on food purchases in Kenya. Methods: A total of 2198 shoppers with diverse backgrounds were recruited from selected supermarkets in three Kenyan main cities (Nairobi, Mombasa, Kisumu) and a small town (Garissa). Participants were randomized to three FOPLs: Red and green Octagon label (RG), Red and Green Octagon with icons (RGI) and a black Octagon Warning label (WL). In the control phase, participants were shown unlabeled images of packaged food products and they responded to a set of questions. In the experimental phase, the same product images were presented with one of the three front-of-pack labels they were randomized to, and participants answered the same questions again. Differences in the proportions of participants correctly identifying the nutrients of concern and the changes in intention to purchase unhealthy foods before and after exposure to FOPLs were analyzed using frequency tables and Chi-Square tests. The effectiveness of the three FOPLs was further assessed using a modified Poisson regression. Results: Results showed that exposure to FOPLs significantly improvement participants' ability to correctly identify nutrients of concern across various food categories. Additionally, FOPLs reduced consumers’ intentions to purchase unhealthy foods, with the Warning Labels (WL) emerging as particularly effective in enhancing consumers' understanding of product healthiness and reducing the intention to purchase unhealthy foods compared to the other two FOPLs. Conclusion: These findings underscore the potential role of FOPLs, particularly the WL as an effective regulatory tool for promoting healthier food choices in Kenya.

Preprint ARTICLE | doi:10.20944/preprints202403.1215.v1

Surveillance of Bacterial Load and Multi-drug Resistant Bacteria on Surfaces of Public Restrooms

Khadega Ibrahim, Maisha Tahsin, Aninda Rahman, Shaikh Mizanoor Rahman, MD Mizanur Rahman

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Public Restrooms; Contamination; Coliforms; Gram-positive; Gram-negative; Antibiotic Sensi-tivity; Antibiotic Resistance; Multidrug Resistant

Online: 21 March 2024 (02:03:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.1735.v1

Heartland Virus: An Evolving Story Of An Emerging Zoonotic And Vector-Borne Disease

Emily K. Mantlo, Nicholas J. Haley

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Heartland Virus; Bandavirus; Amblyomma americanum; Haemaphysalis longicornis; vector-borne disease; Severe Fever with Thrombocytopenia Syndrome Virus

Online: 26 July 2023 (10:23:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0773.v1

Propionic Acidemia, Methylmalonic Acidemia, and cblC Defect: Comparison of Untargeted Metabolomic Profiles

Anna Sidorina, Giulio Catesini, Elisa Sacchetti, Cristiano Rizzo, Carlo Dionisi-Vici

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: methylmalonic acidemia; propionic acidemia; cblC deficiency; untargeted metabolomics

Online: 12 June 2024 (12:23:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1093.v1

Detection of Human Adenovirus and Rotavirus in Untreated Wastewater in Lusaka, Zambia: Opportunity for Establishment of Wastewater Surveillance System for the Community

Ngonda Saasa, Ethel M’kandawire, Joseph Ndebe, Mulenga Mwenda, Fred Chimpukutu, Andrew Nalishuwa Mukubesa, Fred Njobvu, Doreen Mainza Shempela, Jay Sikalima, Carol Chiyesu, Bruce Muvwanga, Sarah M. Nampokolwe, Clement Sulwe, Thokozile Khondiwa, Todd Jennings, Ameck Kamanga, Edgar Simulundu, Conceptor Mulube, Wizaso Mwasinga, Jelaimo Mumeka, John Simwanza, Patrick Sakubita, Otridah Kapona, Chilufya Susan Aneta Mulenga, Musole Chipoya, Kunda Musonda, Nathan Kapata, Nyambe Sinyange, Muzala Kapina, Joyce Siwila, Misheck Shawa, Masahiro Kajihara, Ayato Takada, Hirofumi Sawa, Simulyamana A. Choonga, Roma Chilengi, Earnest Muyunda, King S. Nalubamba, Bernard M. Hang’ombe

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Wastewater; Adenovirus; Rotavirus; Enteric virus; concentration methods

Online: 19 March 2024 (05:18:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0102.v1

Facial Expression Recognition with Fusion Features Extracted from Salient Facial Areas

Yanpeng Liu, Yibin Li, Xin Ma, Rui Song

Subject: Computer Science And Mathematics, Computer Science Keywords: facial expression recognition; fusion features; salient facial areas; hand-crafted features; feature correction

Online: 24 January 2017 (03:28:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1296.v1

Causal Meta-Reinforcement Learning for Multimodal Remote Sensing Data Classification

Wei Zhang, Xuesong Wang, Haoyu Wang, Yuhu Cheng

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Multimodal data; remote sensing; reinforcement learning; meta-learning; causal learning

Online: 22 February 2024 (15:30:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0054.v1

Research on Fault Detection by Flow Sequence Algorithm with Deep Learning Model for Industrial Internet of Things

Dongfeng Lei, Liang Zhao, Dengfeng Chen

Subject: Engineering, Control And Systems Engineering Keywords: Industrial Internet of Things; Deep learning; Subsequence classification; Fault diagnosis

Online: 1 March 2024 (14:05:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0002.v2

Small UAS-Based Wind Feature Identification System Part 1: Integration and Validation

Leopoldo Rodriguez Salazar, Jose A. Cobano, Anibal Ollero

Subject: Engineering, Control And Systems Engineering Keywords: wind prediction; wind estimation; UAS; wind shear; gust; multi-platform integration

Online: 18 January 2017 (09:44:54 CET)

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This paper presents a system for identification of wind features, such as gusts and wind shear. These are of particular interest in the context of energy-efficient navigation of Small Unmanned Aerial Systems (UAS). The proposed system generates real-time wind vector estimates and a novel algorithm to generate wind field predictions. Estimations are based on the integration of an off-the-shelf navigation system and airspeed readings in a so-called direct approach. Wind predictions use atmospheric models to characterize the wind field with different statistical analyses. During the prediction stage, the system is able to incorporate, in a big-data approach, wind measurements from previous flights in order to enhance the approximations. Wind estimates are classified and fitted into a Weibull probability density function. A Genetic Algorithm (GA) is utilized to determine the shaping and scale parameters of the distribution, which are employed to determine the most probable wind speed at a certain position. The system uses this information to characterize a wind shear or a discrete gust and also utilizes a Gaussian Process regression to characterize continuous gusts. The knowledge of the wind features is crucial for computing energy-efficient trajectories with low cost and payload. Therefore, the system provides a solution that does not require any additional sensors. The system architecture presents a modular decentralized approach, in which the main parts of the system are separated in modules and the exchange of information is managed by a communication handler to enhance upgradeability and maintainability. Validation is done providing preliminary results of both simulations and Software-In-The-Loop testing. Telemetry data collected from real flights, performed in the Seville Metropolitan Area in Andalusia (Spain), was used for testing. Results show that wind estimation and predictions can be calculated at 1 Hz and a wind map can be updated at 0.4 Hz. Predictions show a convergence time with a 95% confidence interval of approximately 30 s.

Preprint ARTICLE | doi:10.20944/preprints202406.1443.v1

Bayesian Modelling of Travel Times on the Example of Food Delivery: Part 2 - Model Creation and Handling Uncertainty

Jan Pomykacz, Justyna Gibas, Jerzy Baranowski

Subject: Engineering, Control And Systems Engineering Keywords: online food delivery (OFD); delivery time estimation; Bayesian inference; generalized linear models

Online: 20 June 2024 (14:28:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0789.v1

Molecular Identification and Prevalence of the Mite Carpoglyphus lactis (Acarina: Carpoglyphidae) in Apis mellifera in the Republic of Korea

Thi-Thu Nguyen, Mi-Sun Yoo, Hyang-Sim Lee, So Youn Youn, Se-Ji Lee, Su-Kyoung Seo, Jaemyung Kim, Yun Sang Cho

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Apis mellifera; Carpoglyphus lactis; Cytochrome c oxidase subunit 1 (COI) gene; Molecular identification; Republic of Korea

Online: 13 March 2024 (16:10:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0029.v1

An Optimized Energy Management Strategy for Preheating Vehicle-Mounted Li-Ion Batteries at Subzero Temperatures

Tao Zhu, Haitao Min, Yuanbin Yu, Zhongmin Zhao, Tao Xu, Yang Chen, Xinyong Li

Subject: Engineering, Automotive Engineering Keywords: electric vehicle; battery heat generation; battery degradation; vehicle operation cost; preheating target temperature; heating system

Online: 6 December 2016 (07:46:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0578.v1

Point of Common Connection Voltage Modulated Direct Power Control with Disturbance Observer to Increase of Renewable Energy Acceptance in Power System

Yong Woo Jeong, Woo Young Choi

Subject: Engineering, Electrical And Electronic Engineering Keywords: Grid voltage modulated power control; Point of common connection; Energy storage system; Voltage source inverter; Disturbance observer; Total harmonic distortion

Online: 9 September 2024 (08:00:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0622.v1

A Novel Energy Replenishment Algorithm to Increase Network performance of Rechargeable Wireless Sensor Network

Tariq Tariq, Zhu Wei, Kashif Naseer Qureshi, Muhammad Uzair, Adil Hussain, Muhammad Asif Khosa

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Wireless Recharging; Mobile Charger; Sensor Network; WSN

Online: 9 September 2024 (09:03:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0081.v1

Error Model of the Measurement Chain Containing the Discrete Wavelet Transform Algorithm

Marian Kampik, Jerzy Roj, Łukasz Dróżdż

Subject: Computer Science And Mathematics, Signal Processing Keywords: measurement chain error model; uncertainty estimation; discrete wavelet transform

Online: 2 April 2024 (02:27:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0010.v1

Synergistic Effect of Coadministration of Haemophilus influenzae and Neisseria meningitidis Vaccines on Immune Responses to Meningitis in Mouse Model

Randa H. Ali, Nourtan F. Abdeltawab, Osama A. Hady, Magdy A. Amin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Haemophilus influenza; Neisseria meningitidis; meningitis; vaccine efficacy evaluation; immunization schedule.

Online: 2 January 2017 (18:14:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.1585.v1

One Health Scoping Review of the Epidemiology of Human Fascioliasis across Africa for the Period 2000–2022

Moses Adriko, Edridah M. Tukahebwa, Miph B. Musoke, David Muwanguzi, Stellah Nambuya, Patrick Vudriko, Kalinda Chester, Samson Mukaratirwa, Moses J. Chimbari, Anna-Sofie Stensgaard, Birgitte Vennervald, Lawrence Mugisha

Subject: Public Health And Healthcare, Other Keywords: human-fascioliasis; prevalence; epidemiology; Africa; One-Health

Online: 25 April 2024 (15:07:38 CEST)

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(1)Background: Fascioliasis is considered a neglected tropical disease affecting an estimated 17 million people in more than 70 countries worldwide. The highest prevalence of human fascioliasis is found in regions where livestock farming and consumption of raw or undercooked freshwater plants are common, such as parts of Africa, Asia, Europe, and Latin America. It is responsible for over 90,000 disability-adjusted years of life due to associated abdominal complications. We conducted a study to investigate the prevalence of human fascioliasis through a systematic review and meta-analysis of all available literature in Sun-Saharan Africa.(2). Methods: We screened a total of 126 publications using pubmed online search engine databases; Web of Science and CAB for articles published within a 20-year period between 2000 and 2022. We used a comprehensive search method using a combination of terms, parasite and disease names. The initial search resulted in a screening of articles by title, abstracts and full texts. The relevant information on the prevalence of human fascioliasis in Africa was extracted. Of the 126 publications, 33 articles were selected for meta-analysis. The essential information required was extracted from these documents and determined through statistical analysis in Microsoft Excel for calculating the prevalence of human fascioliasis in sub-Saharan Africa. The variance of each study was assessed using a bimodal distribution and heterogeneity assessment using a I2 index. Analysis was performed using random effects models.(3)Results: A total of 271 articles were searched through the database search and 33 articles were eligible studies that provided qualitative information on the prevalence of human fascioliasis in Africa. These make up 12.17% (n=33). The pooled prevalence estimates for human fascioliasis are 0.032% (IVhet PPE: 0.032% (95%CI 1.4-6.53). The highest prevalence rate was observed in Egypt with a prevalence of 100%. The prevalence of human fascioliasis is very high in some sub-Saharan countries, partly due to neglect of diagnostics, demonstrating the bias of available information for decision-making in human fascioliasis across Africa, given the spatial presence, scarcity and incompleteness are region.(4)Conclusions: The prevalence of Human fascioliasis is very high in some Sub-Saharan Countries partly due to neglect in diagnostics. This presents how highly focal with spatial occurrences, scarcity and patchy the available information for decision making is on Human fascioliasis across the Sub-Saharan African region.

Preprint ARTICLE | doi:10.20944/preprints202408.0202.v1

A Method for Recognition and Coordinate Reference of Autono-Mous Underwater Vehicle to Inspected Objects of Industrial Sub-Sea Structures Using Stereo Images

Valery Bobkov, Alexey Kudryashov

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: autonomous underwater vehicle (AUV); subsea production systems (SPS); computer vision; stereo; visual navigation

Online: 6 August 2024 (03:44:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0075.v1

EEG Signal Recognition Based on Wavelet Transform and ACCLN Network

Xuebin Qin, Jun Deng, Mei Wang, Yizhe Zhang, Pai Wang

Subject: Computer Science And Mathematics, Signal Processing Keywords: BCI; recognition; feature extraction; ACCLN network; RBF network

Online: 19 October 2016 (10:09:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0012.v1

Flexible Techniques to Detect Typical Hidden Errors in Large Longitudinal Datasets

Renato Bruni, Cinzia Daraio, Simone Di Leo

Subject: Computer Science And Mathematics, Computer Science Keywords: big data; information processing; information reconstruction; data quality: longitudinal data sequences

Online: 1 March 2024 (10:33:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1236.v1

Comparative Analysis of Dietary Habits and Obesity Prediction: Body Mass Index versus Body Fat Percentage Classification using Bioelectrical Impedance Analysis

Denisa Pescari, Monica Simina Mihuta, Andreea Bena, Dana Stoian

Subject: Public Health And Healthcare, Primary Health Care Keywords: obesity; overweight; bioimpedance; adipose tissue; dietary habits; body mass index

Online: 16 August 2024 (10:34:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0038.v1

Reconstructing Historical VOC Concentrations in Drinking Water for Epidemiological Studies at a U.S. Military Base: Summary of Results

Morris L. Maslia, Mustafa M. Aral, Perri Z. Ruckart, Frank J. Bove

Subject: Environmental And Earth Sciences, Environmental Science Keywords: historical reconstruction; modeling; drinking water; water quality; VOC; epidemiological study; health study; Camp Lejeune

Online: 4 August 2016 (10:09:23 CEST)

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A U.S. government health agency conducted epidemiological studies to evaluate whether exposures to drinking water contaminated with volatile organic compounds at U.S. Marine Corps Base Camp Lejeune, North Carolina, were associated with increased health risks to children and adults. These health studies required knowledge of contaminant concentrations in drinking water—at monthly intervals—delivered to family housing, barracks, and other facilities within the study area. Because concentration data were limited or unavailable during much of the period of contamination (1950s–1985), the historical reconstruction process was used to quantify estimates of monthly mean contaminant-specific concentrations. This paper integrates many efforts, reports, and papers into a synthesis of the overall approach to, and results from, a drinking-water historical reconstruction study. Results show that at the Tarawa Terrace water treatment plant (WTP) reconstructed (simulated) tetrachloroethylene (PCE) concentrations reached a maximum monthly average value of 183 micrograms per liter (ug/L) compared to a one-time maximum measured value of 215 ug/L and exceeded the U.S. Environmental Protection Agency’s current maximum contaminant level (MCL) of 5 ug/L during the period November 1957–February 1987. At the Hadnot Point WTP, reconstructed trichloroethylene (TCE) concentrations reached a maximum monthly average value of 783 ug/L compared to a one-time maximum measured value of 1,400 ug/L during the period August 1953–December 1984. The Hadnot Point WTP also provided contaminated drinking water to the Holcomb Boulevard housing area continuously prior to June 1972, when the Holcomb Boulevard WTP came on line (maximum reconstructed TCE concentration of 32 ug/L) and intermittently during the period June 1972–February 1985 (maximum reconstructed TCE concentration of 66 ug/L). Applying the historical reconstruction process to quantify contaminant-specific monthly drinking-water concentrations is advantageous for epidemiological studies when compared to using the classical exposed versus unexposed approach.

Preprint ARTICLE | doi:10.20944/preprints202407.0234.v1

Asymmetric Convolution Guided Multipath Fusion Real-Time Semantic Segmentation Networks

Jie Liu, Bing Zhao, Ming Tian

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Semantic segmentation; Asymmetric convolution; Feature misalignment; High-level semantic information

Online: 3 July 2024 (00:20:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0914.v1

Tuning of PID Controllers using Reinforcement Learning for Nonlinear Systems Control

Gheorghe Bujgoi, Dorin Sendrescu

Subject: Engineering, Control And Systems Engineering Keywords: learning-based control; nonlinear systems control; PID controller; bioprocess

Online: 15 March 2024 (12:12:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.0049.v1

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Sevastianos Chatzidavid, Pagona Flevari, Ioanna Tombrou, Georgios Anastasiadis, Maria Dimopoulou

Subject: Medicine And Pharmacology, Hematology Keywords: Sickle cell disease; Pulmonary hypertension; Gene polymorphisms; Gene sequencing

Online: 1 April 2024 (12:44:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1861.v1

Stability Analysis and Dynamic Simulations for Gravity Gradient of a Large Rigid Space Structure

Chenglei Tang, Jialiang Sun, Dongping Jin

Subject: Engineering, Aerospace Engineering Keywords: Stability analysis; Gravity gradient; Large rigid space structure; Orbit dynamics; Natural coordinate formulation

Online: 29 March 2024 (13:45:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0732.v1

Optimizing the Scheduling of Teaching Activities in a Faculty

Francis Patrick Diallo, Cătălin Tudose

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: automatic timetable generation; faculty scheduling; metaheuristics algorithms; resource utilization; scheduling conflicts; scalability; Timefold

Online: 10 September 2024 (10:04:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0099.v1

Advanced Glycation Endproducts form During Ovalbumin Digestion in the Presence of Fructose

Alejandro Gugliucci, Yasmin Bains, Russell Caccavello

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: ovalbumin, allergy; advanced glycation; fructose; fructositis; receptor for advanced glycation end products; inflammation; asthma; chlorogenic acid; Ilex paraguariensis; high fructose corn syrup

Online: 28 February 2017 (10:41:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0400.v1

Development of an Adaptive Fuzzy Integral-Derivative Line-of-Sight Guidance Law for Bathymetric LiDAR Onboard USV

Guoqing Zhou, Jinhuang Wu, Ke Gao, Naihui Song, Guoshuai Jia, Xiang Zhou, Jiasheng Xu, Xia Wang

Subject: Engineering, Marine Engineering Keywords: Line-of-sight guidance law; Unmanned surface vessel; Path-tracking; Fuzzy control; Heading control

Online: 7 June 2024 (02:56:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1509.v1

Evolution and Analysis of Water Yield under the Change of Land Use and Climate Change based on the PLUS-InVEST Model: A Case Study of the Yellow River Basin in Henan Province

Xiaoyu Ma, Shasha Liu, Lin Guo, Junzheng Zhang, Chen Feng, Mengyuan Feng, Yilun Li

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: PLUS model; InVEST model; water yield; land use/land cover; geodetector

Online: 18 July 2024 (23:47:58 CEST)

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Understanding the interrelationships between land use, climate change, and regional water yield is critical for effective water resource management and ecosystem protection. However, comprehensive insights into how water yield evolves under different land use scenarios and climate change remain elusive. This study employs the Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) models, Patch-generating Land Use Simulation (PLUS) model, and Geodetector within a unified framework to evaluate the dynamics of land use, water yield, and their relationships with various factors (meteorological, social, economic, etc.). To forecast the Land Use/Cover Change (LUCC) pattern of the Yellow River Basin by 2030, three scenarios were considered: economic development priority (Scenario1), ecological development priority(Scenario2), and cropland development priority(Scenario3). Climate change scenarios were constructed using CMIP6 data, representing low stress (SSP119), medium stress (SSP245), and high stress (SSP585) conditions. The results show the following: (1) From 2000 to 2020, cropland was predominant in the Yellow River Basin, Henan Province, with significant land conversion to impervious land (construction land) and forest land; (2) Water yield changes during this period were primarily influenced by meteorological factors, with land use changes having negligible impact; (3) By 2030, the water yield of Scenario1 is highest among different land use scenarios, marginally surpassing ecological development priority by 0.5%; (4) Climate scenarios reveal significant disparities, with SSP126 yielding 67% higher water production than SSP245, driven predominantly by precipitation; (5) Geodetector analysis identifies precipitation as the most influential single factor, with significant interactions among meteorological and socio-economic factors. These findings offer valuable insights for policymakers and researchers in formulating land use and water resource management strategies.

Preprint ARTICLE | doi:10.20944/preprints202407.1019.v1

A Rationally Designed H5 Hemagglutinin Subunit Vaccine Provides Broad-Spectrum Protection against Various H5Nx highly Pathogenic Avian Influenza Viruses in Chickens

Xuxiao Zhang, Xin Li, Fushou Zhang, Xiaoping Cui, Xiaoqin Guo, Zhi Sun, Pengju Guo, Ming Liao, Ning Chen

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: avian influenza virus; H5 subtype; subunit vaccine; broad protection

Online: 12 July 2024 (08:42:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1228.v1

Real-Time Document Collaboration System Using Orchestrated Containers

Daniel Iovescu, Cătălin Tudose

Subject: Computer Science And Mathematics, Computer Science Keywords: collaborative work; design document collaboration software; dependable systems; microservices pattern; cloud computing; orchestrated cloud environment; independent containers; collaborative technologies; distributed system architecture

Online: 19 August 2024 (04:26:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0310.v1

Evaluating Mobility in Parkinson’s Disease through Wearable Sensors: A Systematic Review of Digital Biomarkers

Carlos Polvorinos-Fernández, Luis Sigcha, Luigi Borzì, Gabriella Olmo, César Asensio, Juan Manuel López, Guillermo de Arcas, Ignacio Pavón

Subject: Engineering, Bioengineering Keywords: Parkinson’ s disease; digital biomarkers; motor symptoms; ; wearables; body-worn sensors; machine learning

Online: 4 September 2024 (08:32:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0103.v1

Carbon Footprint Optimization with Data Resolution Conversion via Kalman Filter for Smart Energy Hub

Mohammed Mahmoud Khattab, Ahmed Abdelrahim, Eman Youssef, Mostafa Saad Hamad, Rania Elmanfaloty

Subject: Engineering, Control And Systems Engineering Keywords: Smart energy hub; carbon footprin; , dynamic pricing; Kalman filter

Online: 1 August 2024 (17:03:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0894.v1

The Association between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank

Qiuge Zhang, Xueting Qi, Zhaoguo Wang, Dongfeng Zhang, Tong Wang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: sleep disorder; diet; vitamin c; UK Biobank

Online: 11 September 2024 (15:20:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0003.v1

A Single-Stage Buck-Boost Three-Level Neutral-Point-Clamped Inverter with Two Input Sources for the Grid-Tied Photovoltaic Power Generation

Xuefeng Ge, Feng Gao, Mengxing Chen

Subject: Engineering, Electrical And Electronic Engineering Keywords: neutral-point-clamped inverter; buck-boost inverter; single stage conversion; photovoltaic inverter

Online: 1 March 2017 (09:31:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.2006.v1

A High Dimensional and High Sigma Statistical Model for SRAM Read Access Yield Estimation

Dong Xu Zhang, Gang Lu Li, Si Rui Yan

Subject: Engineering, Electrical And Electronic Engineering Keywords: SRAM; Yield Analysis; High Sigma; High Dimension

Online: 30 May 2024 (10:52:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1647.v1

Study on the Mechanical and Aging Properties of an Antibacterial Composite Resin Loaded with Fluoride‐Doped Nano‐Zirconia Fillers

Liyuan Zheng, Yi Zhang, Yuming Bai, Qianju Wu

Subject: Public Health And Healthcare, Other Keywords: Composite resin; Nano-zirconia fillers; Fluoride-releasing; Antibacterial property; Aging test

Online: 29 February 2024 (08:09:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1799.v1

Motor-Control Notions in Health and Disease (What Controls Motor Control?)

Payam Dibaj, Uwe Windhorst

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Motor control; kinematics and kinetics; motoneuron; central pattern generators; reflex; internal models; neural networks; sensory-motor learning; cerebellum; neurological diseases; movement disorders

Online: 29 March 2024 (09:16:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2150.v1

Development of Bio-Products to Enhance Growth-Promoting and Disease Control of Economic Plants

Wilawan Chuaboon, Dusit Athinuwat

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Beneficial bacteria; plant growth promoting

Online: 29 August 2024 (12:19:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1332.v1

Fault-Tolerant Optimal Consensus Control for Heterogeneous Multi-agent System

Yandong Li, Yongan Liu, Ling Zhu, Zehua Zhang

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: uncrewed aerial vehicle; uncrewed ground vehicle; heterogeneous multi-agent system; actuator failures; consensus; Lyapunov stability theory; optimal method

Online: 16 July 2024 (12:28:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0518.v1

‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update

Ranjit Sah, Jaffer Shah, Priyanka Rao, Bijaya Kumar Padhi, Aroop Mohanty, Mohd Iqbal Yatoo, Deepak Chandran, Nahed A El Sh, Praveen SV, Talha Bin Emran, Chiranjib Chakraborty, Kuldeep Dhama

Subject: Biology And Life Sciences, Virology Keywords: Langya virus; henipavirus; animal spillover; zoonosis; public health concerns; prevention and control measures

Online: 28 January 2023 (04:53:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1658.v1

Congenital Rubella Syndrome Burden is Unlikely to Increase with Introduction of Rubella Containing Vaccine

Kurt Frey

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: rubella; congenital rubella syndrome; vaccine introduction; agent-based model

Online: 25 April 2024 (10:15:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1566.v2

Weather Forecasting Using Machine Learning Techniques: Rainfall and Temperature Analysis

Adil Hussain, Ayesha Aslam, Sajib Tripura, VIneet Dhanawat, Varun Shinde

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: rainfall prediction; temperature prediction; ensemble classifier; rain prediction; weather prediction

Online: 13 September 2024 (11:43:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1263.v1

Therapeutic Effect of Shikimic Acid on Heat Stress-Induced Myocardial Damage: Assessment via Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments

Yan Gu, Jingyi Zhang, Min Zheng, Yuyang Qin, Haohong Zheng, Yanchun Hu, Jialiang Xin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Network pharmacology; Heat Stress; Myocardial damage; Shikimic acid; Molecular docking; Molecular dynamics simulation

Online: 19 August 2024 (09:22:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0463.v1

Diagnostic Accuracy of Saliva-Based Testing as a Vibrio cholerae Surveillance Tool

Caroline Cleopatra Chisenga, Bernard Phiri, Harriet Ng'ombe, Mutinta Muchimba, Fraser Liswaniso, Biana Bernshtein, Adam F Cunningham, David Sack, Samuel Bosomprah

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: saliva; vibriocidal antibodies; Cholera; natural infection

Online: 8 March 2024 (03:52:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.2034.v1

Research of Stroke Patient Occurence Associate with Meteorological Factors in Guizhou Mountain Area

Xi Guo, PingXiao Che, XiFou Zhao, ChaoShi Mu, DongYuan Hu, QiangGuo Liu, Juan Wang, Biao Wang, TingTing Liao, HengYuan Yang, Hua Wang, JingYa Zhi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Data fusion; Meteorological factor; Stroke incidence rate; Mountain area

Online: 30 May 2024 (10:51:40 CEST)

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As previous study in many countries shown that stroke patient onsets are not distributed randomly, but associate with meteorological factors. However, the relationship between stroke occurence and meteorological factors remain unknown in mountain area in Guizhou China. This paper firstly introduces multi-source fusion data which is integrated by the mountain meteorological factor, geographic mapping elevation information data and stroke population monitoring of Guizhou province. Mainly elaborates from a few aspects, which concludes data collection, data sorting, data extraction, data cleaning and data production in detail. A completed and detailed meteorological stroke data set was successfully established and multi-source data fusion was realized by the use of Gbase and unified data service interface of Guizhou meteorological big data cloud platform. And we report the impact of meteorological variables in Guizhou mountain area climate on stroke. In this study, we performed a statistical fusion data between January 2017 and December 2020 about stroke incidence rate and meteorological factors respectively, for instance, concerning the mean (Mean), maximum (Max), minimum (Min), median (Median), standard deviation (Std) . We calculated stroke rates (date stroke occurence)/(year stroke occurence) and we investigated the distribution of days included in the label. Results: the distribution of the incidence rate basically conforms to the normal distribution with the label Max 0.007399, label Min 0.000204, label Mean 0.002738, label Median 0.002643, label Std 0.00076. We observed a positive significant correlation of stroke incidence rate directly proportional to the daily temperature difference (between 0 and 20 degrees Celsius), as the value of this factor exhibits variation larger, the incidence rate is gradually increasing. And we investigated from the Pearson correlation coefficients that stroke incidence increasing when meteorological factors at low humidity (less than 40% (RH 80%), temperature higher than 31℃); the 24-hour daily temperature difference varies between 6 and 10℃ (6

Preprint ARTICLE | doi:10.20944/preprints202405.1572.v1

Simulation of the Active Corrector of Power Factor as a Means of Improving the Electromagnetic Compatibility and Energy Efficiency of Electric Locomotive’s Auxiliary Electric Drive

Anatoliy Lavrentyev, Mikhail Pustovetov

Subject: Engineering, Electrical And Electronic Engineering Keywords: power factor active correction; cascaded loops control; AC electric locomotive; auxiliary electric drive; current control loop; voltage control loop; energy saving; electromagnetic compatibility

Online: 23 May 2024 (16:55:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0099.v1

CO₂ Gasification Reactivity of Chars Derived From Zhundong Coal

Yun Liu, Yanjun Guan, Kai Zhang

Subject: Engineering, Control And Systems Engineering Keywords: Zhundong coal; char; CO2 gasification; alkali and alkaline earth metals

Online: 23 January 2017 (09:27:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2290.v1

Enhancing Air Quality Predictions on University Campuses: A Machine Learning Approach to PM2.5 Forecasting at the University of Petroșani

Fabian Arun Panaite, Cosmin Rus, Monica Leba, Andreea Cristina Ionica, Michael Windisch

Subject: Engineering, Control And Systems Engineering Keywords: Environmental Monitoring; Pollutant Analysis; IoT Sensors; Predictive Analytics; Urban Sustainability

Online: 30 July 2024 (09:03:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0539.v1

Genetic Polymorphisms of Il-18 and Their Association with Infectious Diseases – An Update

Durga Arumugam, Janani Semalaiyappan, Balamurugan Mookiah, Vijesh Sreedhar Kuttiatt

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: cytokines; IL-18; gene polymorphism; infectious diseases; precision medicine

Online: 7 September 2024 (15:51:14 CEST)

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Cytokines play a substantial role in the pathophysiology of infectious diseases. Consequently, genetic polymorphisms in cytokine genes can have profound effect on the susceptibility to or protection from infections and also influence the clinical manifestations, disease severity as well as outcome. The objective of this brief narrative review is to provide an update on the recent research findings on the role of genetic polymorphisms of IL-18, a recently discovered cytokine on certain infectious diseases of public health relevance. The current review suggests there is a significant impact of IL-18 polymorphisms on different infectious diseases. The presence of G and T alleles at position -656 is suggested to have a probable protective effect against VL. The −137G/−607C (GC) and −137C/−607C (CC) haplotypes in the promoter region are associated with increased susceptibility to severe malarial anemia. SNPs rs544354 and rs574429 (GC) are linked to a higher risk of P. falciparum infection and increased parasitemia. The -137 C/C genotype and -137 G allele (with G/G genotype) are associated with faster progression to AIDS. In contrast, the IL-18 genotype does not seem to affect overall HIV susceptibility but influences disease progression. The G and GG genotypes at position -137 and allele A at position -607 are likely associated with protection against HBV infection. Conversely, the C allele at position -137 is linked to increased susceptibility to HBV infections. The GG genotype of IL-18 -137 G > C variant is associated with increased susceptibility to pulmonary tuberculosis (PTB). The AC genotype of IL-18 -607A>C has been linked to PTB susceptibility, particularly in patients with co-morbid diabetes mellitus. SNPs −137G/C, 113T/G, and +127C/T are associated with susceptibility to H. pylori infection, indicating that these genetic variants may influence the risk of H. pylori-related diseases. There are conflicting results in studies conducted in different populations (e.g., genetic polymorphism, studies conducted in India and China against HBV infection) highlighting the need for further research with larger sample sizes to resolve discrepancies. Due to the variability in findings, extensive studies in diverse populations are needed to better understand the impact of IL-18 polymorphisms.

Preprint REVIEW | doi:10.20944/preprints202408.2262.v1

Exploiting Venom Toxins in Paratransgenesis to Prevent Mosquito-Borne Disease

Stephanie French, Rachael Da Silva, Janet Storm, Christida E. Wastika, India Cullen, Martijn ten Have, Grant L. Hughes, Cassandra M. Modahl

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Plasmodium; rift valley fever virus; yellow fever virus; Japanese encephalitis virus; West Nile virus; chikungunya virus; dengue virus; zika virus; snake; scorpion; spider; Aedes; Anopheles

Online: 30 August 2024 (16:49:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1875.v1

Improved Performance of the PMSM Sensorless Control System Based on DTC Strategy and SMC Using Fractional Order and Fractal Dimension Calculus

Marcel Nicola, Claudiu Ionel Nicola, Dan Selișteanu, Cosmin Ionete, Dorin Șendrescu

Subject: Engineering, Control And Systems Engineering Keywords: Direct Torque Control; Fractional Order Calculus; Sliding Mode Control; Equilibrium Optimizer

Online: 29 May 2024 (07:07:06 CEST)

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Starting from the fact that one of the global control strategies of the Permanent Magnet Synchronous Motor (PMSM), namely the Direct Torque Control (DTC) type control strategy, is characterised by the fact that the inner flux and torque control loop usually uses hysteresis ON-OFF type controllers and the oscillations introduced by them have to be cancelled out by the outer speed loop controller (which is usually a PI speed controller and whose performance is good around the global operating points and for relatively small variations of the external parameters and disturbances caused in particular by the load torque variation), while retaining the advantages of the DTC strategy, this paper presents the improvement of the performance of the PMSM sensorless control system using Proportional Integrator (PI), PI Equilibrium Optimizer Algorithm (EOA), Fractional Order (FO) PI, Tilt Integral Derivative (TID) and FO Lead-Lag for constant flux, and Sliding Mode Control (SMC) and FOSMC for variable flux. The performance indicators of the control system are the usual ones: response time, settling time, overshoot, steady-state error and speed ripple, plus another one given by the fractal dimension (FD) of the PMSM rotor speed signal, and the hypothesis that the FD of the controlled signal is higher when the control system provides better performance is verified. The paper also presents the basic equations of the PMSM, based on which the synthesis of integer and fractional controllers, the synthesis of an observer for estimating the PMSM rotor speed, electromagnetic torque and stator flux are presented. The comparison of the performance of the proposed control systems and the demonstration of the parametric robustness are performed by numerical simulations in Matlab/Simulink using Simscape Electrical and Fractional Order Modelling and Control (FOMCON). Real-time control based on an embedded system using a TMS320F28379D controller demonstrates the good performance of the PMSM sensorless control system based on the DTC strategy in a complete hardware-in-the-loop (HIL) implementation.

Preprint ARTICLE | doi:10.20944/preprints202408.0336.v1

Steady-state Fault Propagation Characteristics and Fault Isolation in Cascade Electro-hydraulic Control System

Yang Zhang, Rulin Zhou, Lingyu Meng, Jian Shi, Kaixian Ba

Subject: Engineering, Mechanical Engineering Keywords: Fault Diagnosis; Electro-hydraulic Control System; Fault Propagation Characteristics; Turbofan engine

Online: 6 August 2024 (08:27:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1653.v1

Development of a Rapid Detection Method for Ethylene Glycol and Glycolic Acid in Feline Samples: A Response to Increasing Antifreeze Poisoning Incidents in Korea

HyunYoung Chae, Jae Won Byun, Go-Eun Shin, Kyunghyun Lee, Ah-Young Kim, Bok-Kyung Ku, Md Akil Hossain, Tae-Wan Kim, JeongWoo Kang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Antifreeze poisoning; Ethylene glycol; Glycolic acid; Rapid determination method

Online: 21 September 2024 (06:15:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0342.v1

Current-Mode Control of a Distributed Buck Converter with a Lossy Transmission Line

Klaus Röbenack, Daniel Gerbet

Subject: Engineering, Electrical And Electronic Engineering Keywords: switched-mode power supple; buck converter; step-down converter; transmission line; distributed systems; Padé; approximants; PI control

Online: 3 July 2024 (14:14:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1163.v1

Assessment of the Efficacy of the Antihistamine Drug Rupatadine Used Alone or in Combination against Mycobacteria

Xirong Tian, Wanli Ma, Buhari Yusuf, Biyi Su, Jinxing Hu, Tianyu Zhang

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Mycobacteria; Drug resistance; Rupatadine; Drug repurposing; Nonreplicating

Online: 17 June 2024 (15:53:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1094.v1

African Swine Fever Virus Immunosuppression and Virulence Related Gene

Tao Huang, Fangtao Li, Yingju Xia, Junjie Zhao, Yuanyuan Zhu, Yebing Liu, Yingjuan Qian, Xingqi Zou

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: ASFV; immunosuppression; virulence-related genes; pathways

Online: 17 June 2024 (07:57:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1615.v1

Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis – a Pilot Prospective Observational Cohort Study

Lazar A. Chisavu, Viviana M. Ivan, Adelina Mihaescu, Flavia Chisavu, Oana Schiller, Luciana Marc, Flaviu Bob, Adalbert Schiller

Subject: Medicine And Pharmacology, Internal Medicine Keywords: hemodialysis; mortality; cardio-vascular disease; novel biomarkers; cardiac function and structure

Online: 28 February 2024 (13:52:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0096.v1

The Isolation, Purification and Active Mechanism of Sea Cucumber Bone-Strengthening Functional Peptides

Moyi Cheng, Meilian Yang, Xin Mu, Ziqian Jing, Ming Du, Jian Jiao, Zhenyu Wang

Subject: Biology And Life Sciences, Food Science And Technology Keywords: protein, osteoporosis, MC3T3-E1 cells, peptide

Online: 1 April 2024 (14:39:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0546.v1

Multi-Time-Scale Energy Storage Optimization Configuration for Power Balance in Distribution Systems

Qiuyu Lu, Xiaoman Zhang, Yinguo Yang, Qianwen Hu, Guobing Wu, Yuxiong Huang, Yang Liu, Gengfeng Li

Subject: Engineering, Electrical And Electronic Engineering Keywords: energy storage planning; multiple time scales; power balance

Online: 11 March 2024 (09:31:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0332.v1

Electrolyzed Water Treatment for the Control of the Zoonotic Pathogen Vibrio vulnificus in Aquaculture: A One Health Per-Spective

Pablo Ibányez-Payá, Adolfo Blasco, José V. Ros-Lis, Belén Fouz, Carmen Amaro

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Vibrio vulnificus; electrolyzed water; One Health; vibriosis; hypochlorous acid; zoonotic pathogen; sustainable control measures

Online: 4 September 2024 (12:07:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1384.v1

Characteristic Features of Lif Parameters of Microalgae Alexandrium catenella and Their Dependence on Temperature

Alexander Popik, Sergey Voznesenskiy, Tatiana Dunkay, Evgeniy Gamayunov, Tatiana Orlova

Subject: Physical Sciences, Optics And Photonics Keywords: Alexandrium catenella; Prorocentrum cordatum; HAB; laser-induced fluorescence; fluorescence temperature curves; identification

Online: 20 August 2024 (03:39:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0006.v1

Hydrochemical Characteristics and Water Quality Assessment of Surface Water at Xiahe County in Tibetan Plateau Pastoral of China

Qian Zhang, Shengli Wang, Muhammad Yousaf, Zhongren Nan, Shuixian Wang, Jianmin Ma, Depeng Wang, Fei Zang

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: surface water; Tibetan Plateau pastoral area; Xiahe County; hydrochemical characteristics; fuzzy comprehensive method; water quality

Online: 2 August 2016 (04:20:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1737.v1

Building Information Modeling and Digital Twin Approaches in Building Automation and Distributed IoT Networks – Review and New Challenges Discussion

Gabriela Walczyk, Andrzej Ożadowicz

Subject: Engineering, Electrical And Electronic Engineering Keywords: building information modeling; digital twin; building automation and control systems; internet of things; energy efficiency; EN ISO 52120; smart readiness indicator

Online: 27 May 2024 (11:20:51 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202409.1377.v2

Tellurium-Doped Bioactive Glassinduces Ferroptosis in Osteosarcoma Cells Regardless of FSP1

Elzbieta Pańczyszyn, Mari Lallukka, Mara Gagliardi, Valentina Saverio, Romina Monzani, Marta Miola, Enrica Verné, Marco Corazzari

Subject: Biology And Life Sciences, Life Sciences Keywords: Ferroptosis; Tellurium; osteosarcoma; FSP1; bioactive glass

Online: 19 September 2024 (11:51:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1309.v1

Conserved Functions of Orthohepadnavirus X Proteins to Inhibit Type-I Interferon Signaling

Amonrat Choonnasard, Maya Shofa, Tamaki Okabayashi, Akatsuki Saito

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Orthohepadnavirus, X protein, domestic cat hepadnavirus (DCH), hepatitis B virus (HBV), interferon-β signaling pathway

Online: 22 February 2024 (13:25:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1995.v1

Bacterial and Viral Co-Infections in COVID-19 Patients: Etiology and Clinical Impact

Iveta Rumenova Madzharova, Ivelina Trifonova, Neli Stoyanova Korsun, Viktoria Levterova, Petar Velikov, Silvya Voleva, Ivan Ivanov, Daniel Ivanov, Ralitsa Yordanova, Tatiana Tcherveniakova, Svetla Angelova, Iva Christova

Subject: Public Health And Healthcare, Other Keywords: SARS-CoV-2; co-infection; respiratory viruses; Haemophilus influenzae; RSV

Online: 28 August 2024 (05:13:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0722.v1

Benchmarking of DNA Extraction Methods for Metagenomics, 16S rRNA Databases and Assessment of the Skimmed Milk Flocculation for Bacterial Enrichment for Metagenomics from Water Samples

Deyan Donchev, Ivan Stoikov, Antonia Diukendjieva, Ivan N. Ivanov

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: skimmed milk flocculation; vacuum filtration; bacterial metagenomics; benchmarking; DNA extraction; water samples; taxonomic composition; MIQ score; mock standard

Online: 10 September 2024 (10:08:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.2145.v1

Viruses Identified in Shrews (Soricidae) and Their Biomedical Significance

Huan-Yu Gong, Rui-Xu Chen, Su-Mei Tan, Xiu Wang, Ji-Ming Chen, Yuan-Long Zhang, Ming Liao

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: shrew; virus; diversity; public health; epidemiology; risk

Online: 29 August 2024 (12:13:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0189.v1

Promoting Effect of Inorganic Alkali on Carbon Dioxide Adsorption in Amine-Modified MCM-41

Yang Teng, Lijiao Li, Gang Xu, Kai Zhang, Kaixi Li

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: amine-modified MCM-41; CO2 adsorption; inorganic alkali; alkali amounts

Online: 22 August 2016 (05:47:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0829.v1

GRK5KO Mouse Mirrors Mild Cognitive Impairment due to Alzheimer’s Disease

William Z. Suo

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer’s disease; Mild cognitive impairment due to Alzheimer’s disease; aging; animal model; GRK5 deficiency; GRK5 knockout mouse.

Online: 12 April 2024 (08:03:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0203.v1

Antibiotic Treatment of Carbapenem-Resistant Acinetobacter baumannii Infections in View of the Newly Developed β-Lactams: A Narrative Review of the Existing Evidence

Francesca Serapide, Maurizio Guastalegname, Sara Palma Gullì, Rosaria Lionello, Andrea Bruni, Eugenio Garofalo, Federico Longhini, Enrico Maria Trecarichi, Alessandro Russo

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Acinetobacter baumannii; carbapenem-resistance; sulbactam-durlobactam; cefiderocol; guidelines; real-world evidence

Online: 6 May 2024 (08:47:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0243.v1

Generation of an Alzheimer’s Disease Model Derived from Induced Pluripotent Stem Cells with an APP Gene Mutation

Yena Kim, Binna Yun, Byoung Seok Ye, Bo-Young Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s disease; amyloid precursor protein; cerebral organoid; disease modeling; drug screening; induced pluripotent stem cells; organoids; tau pathology

Online: 6 May 2024 (07:37:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1110.v1

Modeling of the 4th Generation Toyota Prius Traction Machine as the Reference for Future Designs

Michal Gierczynski, Rafal Jakubowski, Emil Kupiec, Miroslaw Seredynski, Maciej Jaworski, Lech Grzesiak

Subject: Engineering, Electrical And Electronic Engineering Keywords: Field Weakening; Finite Element Method Model; Internal Permanent Magnet Synchronous Motor; Reverse Engineering; Toyota Prius

Online: 14 August 2024 (19:43:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1499.v1

Spectrum and Incidences of Adverse Reactions Post-immunizations in Taiwanese Population (2014 – 2019): An Analysis Using the National Vaccine Injury Compensation Program

Wan-Chun Lai, Chin-Hui Yang, Yhu-Chering Huang, Nan-Cheng Chiu, Chih-Jung Chen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: vaccine reactogenicity; adverse reactions; adverse events following immunization; vaccine injury compensation program

Online: 21 August 2024 (00:13:53 CEST)

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