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Study reveals how NPAS4 regulates drug-context associations and impacts relapse

Most people wouldn't think twice after seeing sugar spilled on a counter. But for someone with a history of cocaine use, this visual cue could trigger powerful associations with their past drug use and a compulsive urge to seek the drug.

9 Aug 2024

Controllable chiral switching in double-helical foldamers for advanced molecular systems

The deoxyribonucleic acid or DNA, the molecular system that carries the genetic information of living organisms, can transcribe and amplify information using its two helical strands.

9 Aug 2024

Novel molecular signaling pathway found to play a crucial role in maintaining the skin barrier

Our skin–the body's largest organ–provides the first line of defense against infections and many other threats to our health.

9 Aug 2024

Columbia study reveals bacteria create free-floating genes, challenging genetic code norms

Since the genetic code was first deciphered in the 1960s, our genes seemed like an open book. By reading and decoding our chromosomes as linear strings of letters, like sentences in a novel, we can identify the genes in our genome and learn why changes in a gene's code affect health.

9 Aug 2024

New insights into topoisomerase I inhibition reveal potential pathways for cancer therapies

A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a protein crucial for many biological processes in cells.

8 Aug 2024

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced ISM6331, potential best-in-class pan-TEAD inhibitor, has received the U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for the treatment of mesothelioma, following the grant of Orphan Drug Designation (ODD) in June 2024. It brings the total number of IND-approved molecules of Insilico to nine.

8 Aug 2024

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Using zebrafish "Avatars", an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López – a former PhD student at the lab now working at the Universidad de las Américas in Quito, Ecuador – and colleagues studied the initial steps of the Bacillus Calmette-Guérin (BCG) vaccine's action on bladder cancer cells.

8 Aug 2024

Breakthrough molecule reverses Alzheimer's symptoms

In a new study, a molecule identified and synthesized by UCLA Health researchers was shown to restore cognitive functions in mice with symptoms of Alzheimer's disease by effectively jumpstarting the brain's memory circuitry.

8 Aug 2024

Nasal microbiome composition influences how well multi-resistant bugs can thrive in the nose

Whether dangerous staphylococci survive in the nose depends on what other bacteria are present - and how they obtain iron.

7 Aug 2024

How social drinking and dopamine influence alcohol-induced euphoria in fruit flies

Grab a drink with friends at happy hour and you're likely to feel chatty, friendly and upbeat. But grab a drink alone and you may experience feelings of depression.

6 Aug 2024

New target identified for melanoma resistant to current therapies

Some proteins, such as programmed cell death protein 1 (PD1), can stop the immune system from attacking cancer cells and, therefore, support the growth of cancer.

6 Aug 2024

Dopamine treatment can reduce Alzheimer's plaques and improve memory

A new way to combat Alzheimer's disease has been discovered by Takaomi Saido and his team at the RIKEN Center for Brain Science (CBS) in Japan.

6 Aug 2024

New dual-purpose contrast agent revolutionizes PET and MRI integration for enhanced diagnosis

A research team from IOCB Prague, working in collaboration with the University of Tübingen, Germany, and the Faculty of Science, Charles University, has developed a new type of contrast agent that can be used in both magnetic resonance imaging (MRI) and positron emission tomography (PET).

5 Aug 2024

Cannabigerol shows promise in reducing anxiety and stress, study finds

Whether the phytocannabinoid cannabigerol impacted mood, stress, and anxiety and caused any related adverse effects of cognitive or motor impairment.

5 Aug 2024

Novel antibiotic compound shows promise against drug-resistant bacteria and flesh-eating infections

Researchers at Washington University School of Medicine in St. Louis have developed a novel compound that effectively clears bacterial infections in mice, including those that can result in rare but potentially fatal "flesh-eating" illnesses.

2 Aug 2024

How machine learning is accelerating research in structural biology

For Lucas Farnung, there is no question more fascinating than how a single fertilized egg develops into a fully-functioning human.

2 Aug 2024

Using advanced CRISPR to boost efficiency of CAR-T cell therapies

CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the USA and a year later in Europe for treating acute lymphoblastic leukemia (ALL).

2 Aug 2024

Researchers identify strategy to design safer opioids

Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose.

2 Aug 2024

Single-cell RNA sequencing sheds light on stroke-induced brain damage

Strokes lead to irreversible damage to the brain and are one of the most common causes of dependency or death.

1 Aug 2024

Researchers develop highly reactive RNA building blocks for enhanced chip production

An international research team led by the University of Vienna has succeeded in developing a new version of RNA building blocks with higher chemical reactivity and photosensitivity. This can significantly reduce the production time of RNA chips used in biotechnological and medical research. The chemical synthesis of these chips is now twice as fast and seven times more efficient. The results of the research were recently published in the prestigious journal Science Advances.

1 Aug 2024

Molecule News and Research

Study reveals how NPAS4 regulates drug-context associations and impacts relapse

Controllable chiral switching in double-helical foldamers for advanced molecular systems

Novel molecular signaling pathway found to play a crucial role in maintaining the skin barrier

Columbia study reveals bacteria create free-floating genes, challenging genetic code norms

New insights into topoisomerase I inhibition reveal potential pathways for cancer therapies

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Breakthrough molecule reverses Alzheimer's symptoms

Nasal microbiome composition influences how well multi-resistant bugs can thrive in the nose

How social drinking and dopamine influence alcohol-induced euphoria in fruit flies

New target identified for melanoma resistant to current therapies

Dopamine treatment can reduce Alzheimer's plaques and improve memory

New dual-purpose contrast agent revolutionizes PET and MRI integration for enhanced diagnosis

Cannabigerol shows promise in reducing anxiety and stress, study finds

Novel antibiotic compound shows promise against drug-resistant bacteria and flesh-eating infections

How machine learning is accelerating research in structural biology

Using advanced CRISPR to boost efficiency of CAR-T cell therapies

Researchers identify strategy to design safer opioids

Single-cell RNA sequencing sheds light on stroke-induced brain damage

Researchers develop highly reactive RNA building blocks for enhanced chip production

A new way of characterising biomolecules eBook

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

A Discussion with Hologic’s Tim Simpson on the Future of Cervical Cancer Screening

From Waste to Taste: The Transformative Power of Fermented Foods

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