Biomedical papers, 2023 (vol. 167), issue 2

Reviews

Current causes of mesothelioma: how has the asbestos ban changed the perspective?

Magdalena Janosikova, Marie Nakladalova, Ladislav Stepanek

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):99-108 | DOI: 10.5507/bp.2023.008  

This paper maps the etiology of mesothelioma with respect to current risks and the situation where the asbestos ban is in place.  It shows what other factors may apply and under what circumstances. Also, what are the possible routes of asbestos exposure today.

Postdischarge nausea and vomiting (PDNV) in children: A review and observational study

Michal Frelich, Vojtech Vodicka, Ondrej Jor, Filip Bursa, Martin Formanek, Peter Sklienka, Vaclav Prochazka

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):109-115 | DOI: 10.5507/bp.2023.020  

Postdischarge nausea and vomiting (PDNV) is the main cause of patient´s discomfort, worsens postoperative morbidity and put the child at risk of dehydrataion, dehiscence of surgical wound, bleeding and hospital readmission in the most serious cases. This paper reviews currently available data on the incidence, risk factors and management of postdischarge nausea and vomiting (PDNV) in pediatric patients. This narrative review is extended by an observational study of the incidence of PDNV.

Expansive intracardiac leiomyosarcoma - a combined therapeutic approach resulting in survival with complete remission. A literature review and case report

Jan Juchelka, Martin Simek, Pavel Marcian, Jiri Ehrmann, Petr Santavy

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):116-120 | DOI: 10.5507/bp.2022.011  

A literature review and report of a rare, highly malignant and unusually large heart tumor, where an individually tailored combination of complex surgical and oncological treatment resulted in long-term survival with complete remission of the disease.

Original papers

Analysis of cerebrospinal fluid cells by flow cytometry: Comparison to conventional cytology

David Zeman, Kamila Revendova, Radovan Bunganic, Marketa Ryzi, Petra Masarovicova, Pavlina Kusnierova, Vera Kotrlova, Pavel Hradilek, David Stejskal, Vojtech Thon

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):121-130 | DOI: 10.5507/bp.2022.021  

Cerebrospinal fluid cells were analyzed by both conventional cytology and flow cytometry in 42 patients; basic subpopulations of CSF cells could be determined by flow cytometry even in samples with normal cell counts using no more than 2.4 mL CSF. The ratio of lymphocytes to monocytes was higher for cytocentrifuged CSF sediment after precentrifugation but comparable between flow cytometry and cytocentrifuged native CSF; the proportion of granulocytes was higher in flow cytometry compared to conventional cytology.

Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction

Karin Chytilova, Adela Galandakova, Katerina Valentova, Peter Tvrdy

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):131-138 | DOI: 10.5507/bp.2021.055  

Inflammatory periodontal diseases are related to dental plaque formation and are influenced by its microbial composition and the host immune system. The dry socket (alveolar osteitis), which may occur as an inflammatory complication after third molar extraction, is similar in many ways. For this reason, efforts are currently underway to formulate preparations that inhibit dental plaque formation and suppress inflammation. The results of this pilot study show that the combination of the phenolic fraction of Lonicera caerulea fruit and Macleaya cordata alkaloids has beneficial effects on antioxidant imbalance and inflammation both in vitro and in a clinical study.

Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx

Richard Pink, Jaroslav Michalek, David Kral, Michal Mozola, Pavel Benes, Saskova Lenka, Zdenek Dvorak

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):139-144 | DOI: 10.5507/bp.2021.062  

This evaluation clearly shows the connection between type of bone invasion, tumour differentiation and MDV and this can be used in the diagnosis of tumours of the oral cavity and oropharynx and in determining the radicality of the oncological therapy.

Preoperative nutritional support for patients undergoing elective colorectal cancer surgery - does it really work?

Milan Tesar, Veronika Kozusnikova, Lubomir Martinek, Stefan Durdik, Peter Ihnat

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):145-151 | DOI: 10.5507/bp.2022.009  

The authors evaluated the effect of preoperative oral nutritional supplements (ONS) on the self-sufficiency, physical, and nutritional status of patients who had elective colorectal resections. Patient self-sufficiency in the postoperative period was comparable between groups (P=0.313), the prevalence of postoperative complications was also comparable (P=0.73). Physical and nutritional status were not influenced by preoperative ONS. Preoperative administration of ONS in patients undergoing elective colorectal surgery did not reduce postoperative morbidity or enhance recovery.

Driver and actionable mutations in younger patients with lung cancer - are we searching properly?

Monika Bratova, Kristian Brat, Zdenek Pavlovsky, Jiri Sana, Ondrej Slaby

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):152-156 | DOI: 10.5507/bp.2023.012  

Lung cancer is a leading cause of cancer deaths. Although the most affected age group is in the 6th decade occasionally we meet very young patients with the disease. The authors looked at a group of young patients under 40 years with this diagnosis, its characteristics, the diversity of the group and the potential pathogenesis of lung cancer at such a young age. Data of 17 individuals diagnosed during 2011–2020 at the Department of Respiratory Diseases, University Hospital Brno, Czech Republic, were analysed. From 8 valid samples, we detected actionable mutation in 75% patients.

Painless form of chronic pancreatitis - multicentre study

Petr Dite, Marie Precechtelova, Martina Bojkova, Martin Lovecek, Radek Ambroz, Arnost Martinek, Jiri Dolina

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):157-161 | DOI: 10.5507/bp.2023.019  

Approximately one in ten patients with chronic pancreatitis have primary painless disease with the major being attributed to an idiopathic etiology. Knowledge of the prominent symptoms is important for diagnosis – these patients may have any combination of pancreatic steatorrhea, diabetes mellitus, pancreatic calcifications and unclear loss of body-weight. Even if the incidence of this form of chronic pancreatitis is relatively low, early diagnosis is paramount.  Further research on this patient population is necessary.

The predictive value of the systemic immune-inflammatory index for left atrial appendage thrombus in non-valvular atrial fibrillation

Fatih Koca, Fatih Levent, Baris Sensoy, Erhan Tenekecioglu

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):162-168 | DOI: 10.5507/bp.2023.007  

To the best of the authors‘ knowledge, there has been so far no investigation on any association between the systemic immune-inflammatory index and left atrial appendage thrombus in non-valvular atrial fibrillation.

Impact of admitting department on the management of acute coronary syndrome after an out of hospital cardiac arrest

Pavel Jansky, Zuzana Motovska, Josef Kroupa, Petr Waldauf, Petr Kafka, Jiri Knot, Jiri Jarkovsky

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):169-176 | DOI: 10.5507/bp.2022.044  

This article compares the approach of a cardiac care unit (CCU) and the general intensive care unit (GICU) to the management of patients after Out-of-Hospital Cardiac Arrest (OHCA) of coronary etiology. Specifically, it concerns compliance with recommendations for myocardial revascularization and appropriate pharmacotherapy. It was found that adherence was higher in CCU in all monitored parameters.

Pharmacotherapy of diabetes mellitus in patients with heart failure - a nation-wide analysis of contemporary treatment

Marek Vicha, Tomas Skala, Libor Jelinek, Ludek Pavlu, Jiri Jarkovsky, Ladislav Dusek, Klara Benesova, Milos Taborsky

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):177-184 | DOI: 10.5507/bp.2021.069  

Summary of the evolution of the use of insulin and non-insulin therapy in people with heart failure and diabetes mellitus. A positive trend in the use of new oral antidiabetic drugs is evident. Some of these are becoming an integral part of heart failure therapy.

Clinical presentation and pulmonary function tests in post-acute COVID-19 patients

Samuel Genzor, Petr Jakubec, Milan Sova, Jan Mizera, Pavol Joppa, Radim Burget, Pavol Pobeha

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):185-191 | DOI: 10.5507/bp.2022.039  

This is an analysis of post-acute COVID symptoms and the pulmonary function test (PFT) results in patients surviving the native strain of the virus (Wuhan variant). There were 785 subjects (345 male) mean age 53.8 (SD 14.6); PFT results showed a decrease with disease severity; anosmia during the acute phase was associated with mild course of the disease, persisting dyspnoea was more frequent in the more severe disease groups; female sex was identified as a possible risk factor for persisting symptoms in the post-acute phase.

Median nerve ultrasonography examination correlates with electrodiagnostic studies for the diagnosis of moderate to severe carpal tunnel syndrome

Pavel Potuznik, Petr Hosek, Rudolf Kotas

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):192-198 | DOI: 10.5507/bp.2021.068  

Ultrasonography is a reliable alternative to electrodiagnosis for diagnosing moderate to severe carpal tunnel syndrome. The data demonstrate that the median nerve cross-sectional area had  the best diagnostic ability of  the  parameters tested. The median nerve cross-sectional area at the tunnel inlet, for instance at a suggested threshold value of 12 mm2, could substantially help us indicate surgical CTS treatment.

Case report

Bilateral optic neuropathy as a complication of allogeneic hematopoietic stem cell transplantation

Jan Lestak, Petr Mlcak, Adam Kuba, Klara Maresova, Martin Kyncl, Jaroslav Tintera, Martin Fus

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):199-207 | DOI: 10.5507/bp.2021.056  

This case study describes a rare neuro-ophthalmological complication of allogenic hematopoietic stem cell transplantation. Marked reduction of visual acuity on both eyes accompanied by bilateral optic disc edema firstly led to diagnosis of retrobulbar neuritis. Following complete ophthalmological examination supplemented by functional MRI, we established a multifactorial etiology with the participation of vascular and inflammatory changes.

Short communication

Population pharmacokinetics of three alternative prophylactic antibiotics during cardiac surgery with extracorporeal circulation

Petr Santavy, Vendula Kubickova, Martin Sima, Karel Urbanek

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):208-211 | DOI: 10.5507/bp.2022.033  

A prospective pharmacokinetic study was carried out on patients undergoing cardiac surgery using extracorporeal circulation, to describe the population pharmacokinetics of prophylactically administered ampicillin, cefazolin and ciprofloxacin. Measured serum concentration-time profiles of the three antibiotics were analyzed using a nonlinear mixed-effects modeling approach. The main factor determining the achievement of the PK/PD target was found to be eGFR in ampicillin and cefazolin and body weight in ciprofloxacin.