Inferences, questions and possibilities in Toll-like receptor signalling.

Beutler B

doi:10.1038/nature02761

Inferences, questions and possibilities in Toll-like receptor signalling.

Beutler B ¹

Affiliations

1. Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA.
Authors
Beutler B¹
(1 author)

Nature, 01 Jul 2004, 430(6996):257-263
https://doi.org/10.1038/nature02761 PMID: 15241424

Review

Abstract

The Toll-like receptors (TLRs) are the key proteins that allow mammals--whether immunologically naive or experienced--to detect microbes. They lie at the core of our inherited resistance to disease, initiating most of the phenomena that occur in the course of infection. Quasi-infectious stimuli that have been used for decades to study inflammatory mechanisms can activate the TLR family of proteins. And it now seems that many inflammatory processes, both sterile and infectious, may depend on TLR signalling. We are in a good position to apply our understanding of TLR signalling to a range of challenges in immunology and medicine.

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Read article at publisher's site: https://doi.org/10.1038/nature02761

References

Articles referenced by this article (85)

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Data

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This data has been provided by curated databases and other sources that have cited the article.

Proteins in UniProt (Showing 5 of 7)

Toll-like receptor 2(UniProt - O60603)
Pulmonary surfactant-associated protein A1(UniProt - Q8IWL2)
Monocyte differentiation antigen CD14(UniProt - P08571)
Toll-like receptor 1(UniProt - Q15399)
Pulmonary surfactant-associated protein A2(UniProt - Q8IWL1)

Go to all (7) records in UniProt

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Search life-sciences literature (44,389,261 articles, preprints and more)

Inferences, questions and possibilities in Toll-like receptor signalling.

Affiliations

Authors

Abstract

Full text links

References

Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product.

The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults.

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.

Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses.

Toll-like receptors: critical proteins linking innate and acquired immunity.

Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.

Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Revisiting the evolution of bow-tie architecture in signaling networks.

The Recombinant Profilin from Free-Living Amoebae Induced Allergic Immune Responses via TLR2.

Maintenance of homeostasis by TLR4 ligands.

The Effect of Heparin and Other Exogenous Glycosaminoglycans (GAGs) in Reducing IL-1β-Induced Pro-Inflammatory Cytokine IL-8 and IL-6 mRNA Expression and the Potential Role for Reducing Inflammation.

Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination.

Data

Data that cites the article

Proteins in UniProt (Showing 5 of 7)

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Inferences, questions and possibilities in Toll-like receptor signalling.

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Abstract

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