Abstract
Objective
Calcium antagonists, angiotensin-converting enzyme (ACE) inhibitors and other drug classes either alone or in combination have been recommended for the treatment of hypertension. Nifedipine gastrointestinal therapeutic system (GITS) 20 mg is a new low-dose formulation with an improved tolerability. The aim of the present study was to compare the effects of nifedipine GITS 20 mg and enalapril 20 mg on blood pressure and circulating adhesion molecules in hypertensive patients.Methods
This randomized, double-blind, multicentre trial compared the blood pressure lowering effects of a 12-week treatment of nifedipine GITS 20 mg vs enalapril 20 mg in 264 patients with mild-to-moderate hypertension.Results
Nifedipine GITS 20 mg induced a reduction of clinic blood pressure, which was similar to that observed with enalapril 20 mg. Nifedipine GITS and enalapril lowered mean sitting diastolic blood pressure by 11.8 and 12.4 mmHg, respectively, while systolic blood pressure was reduced by 15.3 and 16.3 mmHg, respectively. Ambulatory blood pressure monitoring-derived blood pressure data showed similar results in both groups without any statistically significant differences between treatments. Both enalapril and nifedipine tended to reduce ICAM-1 and E-selectin, while only nifedipine reduced von Willebrand factor. Both treatments were well tolerated.Conclusions
Our findings demonstrate a similar antihypertensive effectiveness of a low dose (20 mg) of nifedipine GITS in comparison with a standard dose of enalapril (20 mg). Given its clinical efficacy and good tolerability, low-dose nifedipine GITS may be considered a valuable treatment option for hypertensive patients.Citations & impact
Impact metrics
Citations of article over time
Smart citations by scite.ai
Explore citation contexts and check if this article has been
supported or disputed.
https://scite.ai/reports/10.1080/08037050510034257
Article citations
A network meta-analysis comparative the efficacy of angiotensin-converting enzyme inhibitors and calcium channel blockers in hypertension.
Medicine (Baltimore), 103(24):e37856, 01 Jun 2024
Cited by: 0 articles | PMID: 38875375 | PMCID: PMC11175899
ABO gene polymorphisms are associated with acute coronary syndrome and with plasma concentration of HDL-cholesterol and triglycerides.
Biomol Biomed, 23(6):1125-1135, 03 Nov 2023
Cited by: 0 articles | PMID: 37334748 | PMCID: PMC10655879
New Ideas for the Prevention and Treatment of Preeclampsia and Their Molecular Inspirations.
Int J Mol Sci, 24(15):12100, 28 Jul 2023
Cited by: 4 articles | PMID: 37569476 | PMCID: PMC10418829
Review Free full text in Europe PMC
Angiotensin-converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta-analysis.
J Clin Hypertens (Greenwich), 25(8):661-688, 07 Jul 2023
Cited by: 1 article | PMID: 37417783 | PMCID: PMC10423763
Review Free full text in Europe PMC
Mathematical modeling of antihypertensive therapy.
Front Physiol, 13:1070115, 14 Dec 2022
Cited by: 2 articles | PMID: 36589434 | PMCID: PMC9795234
Go to all (13) article citations
Similar Articles
To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.
Equivalent reduction of proteinuria in hypertensives by either nifedipine GITS or enalapril: disparate effects on neurohormones and ambulatory blood pressure and the influence of salt.
Cardiology, 88 Suppl 3:38-42, 01 Jan 1997
Cited by: 7 articles | PMID: 9397292
Comparative effects of felodipine ER, amlodipine and nifedipine GITS on 24 h blood pressure control and trough to peak ratios in mild to moderate ambulatory hypertension: a forced titration study.
Can J Cardiol, 14(5):682-688, 01 May 1998
Cited by: 8 articles | PMID: 9627524
Underestimation of 24-hour hypotensive efficacy of nifedipine GITS versus enalapril: ambulatory recording as an adjunct to clinical blood pressure measurement.
Blood Press, 9(4):221-226, 01 Jan 2000
Cited by: 2 articles | PMID: 11055475
Angiotensin converting enzyme inhibition and dihydropyridine calcium channel blockade in the treatment of left ventricular hypertrophy in arterial hypertension.
Minerva Cardioangiol, 50(3):169-174, 01 Jun 2002
Cited by: 5 articles | PMID: 12107398
Review
Trough:peak ratio of the blood pressure response to dihydropyridine calcium antagonists. Italian Nifedipine GITS Study Group.
J Hypertens Suppl, 12(8):S97-106, 01 Nov 1994
Cited by: 5 articles | PMID: 7707165
Review