Regulatory T cells and immune tolerance.

Sakaguchi S; Yamaguchi T; Nomura T; Ono M

doi:10.1016/j.cell.2008.05.009

Regulatory T cells and immune tolerance.

Affiliations

1. Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Authors
Sakaguchi S¹
(1 author)

ORCIDs linked to this article

Cell, 01 May 2008, 133(5):775-787
https://doi.org/10.1016/j.cell.2008.05.009 PMID: 18510923

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Abstract

Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.

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References

Articles referenced by this article (114)

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Deciphering the role of protein kinase A in the control of FoxP3 expression in regulatory T cells in health and autoimmunity.
Lepore MT, Bruzzaniti S, La Rocca C, Fusco C, Carbone F, Mottola M, Zuccarelli B, Lanzillo R, Brescia Morra V, Maniscalco GT, De Simone S, Procaccini C, Porcellini A, De Rosa V, Galgani M, Cassano S, Matarese G
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Recombinant FOXN1 fusion protein increases T cell generation in old mice.
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9-cis-retinoic acid signaling in Sertoli cells regulates their immunomodulatory function to control lymphocyte physiology and Treg differentiation.
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https://en.wikipedia.org/wiki/Regulatory_T_cell

Search life-sciences literature (44,654,770 articles, preprints and more)

Regulatory T cells and immune tolerance.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Dependence of self-tolerance on TRAF6-directed development of thymic stroma.

Interleukin-2-dependent mechanisms of tolerance and immunity in vivo.

In vivo instruction of suppressor commitment in naive T cells.

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells.

Human CD4+CD25+ regulatory T cells.

Natural regulatory T cells in infectious disease.

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity.

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation.

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.

Cyclophosphamide-induced type-1 diabetes in the NOD mouse is associated with a reduction of CD4+CD25+Foxp3+ regulatory T cells.

Citations & impact

Impact metrics

Citations of article over time

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Article citations

Immunosuppressive tumor microenvironment in the progression, metastasis, and therapy of hepatocellular carcinoma: from bench to bedside.

Dual blockade immunotherapy targeting PD-1/PD-L1 and CTLA-4 in lung cancer.

Deciphering the role of protein kinase A in the control of FoxP3 expression in regulatory T cells in health and autoimmunity.

Recombinant FOXN1 fusion protein increases T cell generation in old mice.

9-cis-retinoic acid signaling in Sertoli cells regulates their immunomodulatory function to control lymphocyte physiology and Treg differentiation.

Other citations

Wikipedia

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Search life-sciences literature (44,654,770 articles, preprints and more)

Regulatory T cells and immune tolerance.

Author information

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Authors

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Abstract

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References

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