BBC Russian
Svoboda | Graniru | BBC Russia | Golosameriki | Facebook

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Interleukin-4 induces secretion of CSF for granulocytes and CSF for macrophages by peripheral blood monocytes.

Author information

Affiliations

  • 1. Department of Hematology, Johannes Gutenberg University, Mainz, FRG.
      Authors
    • Wieser M 1
    (1 author)

Blood, 01 Apr 1989, 73(5):1105-1108
PMID: 2467700 

Abstract 

T cells are known to interact cooperatively with monocytes to produce Colony-Stimulating Factors (CSF), although T cell-mediated signals leading to CSF secretion by monocytes are not completely understood. We have made use of Northern blot hybridization and specific bioassays to study the effects of the T cell product interleukin-4 (IL-4) on monocyte CSF expression. The results suggest a previously unrecognized role of IL-4 as a CSF inducer since exposure of monocytes to IL-4 resulted in accumulation of transcripts for granulocyte-CSF (G-CSF) and macrophage-CSF (M-CSF). Consequently, IL-4-activated monocytes released factors in their culture supernatants biologically and antigenically indistinguishable from G- and M-CSF.

Full text links 

Free to read at www.bloodjournal.org
http://www.bloodjournal.org/cgi/content/abstract/73/5/1105

Citations & impact 

Impact metrics

60
Citations
Jump to Citations

Citations of article over time

Article citations

Go to all (60) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.