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The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos.

Author information

Affiliations

  • 1. The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345 Gothenburg, Sweden; Institute for Clinical Molecular Biology, University of Kiel, Schittenhelmstraße 12, 24105 Kiel, Germany.
      Authors
    • Sommer F 1
    (1 author)
  • 2. The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345 Gothenburg, Sweden.
      Authors
    • Ståhlman M 2
    (1 author)
  • 3. Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, NC 27701, USA.
      Authors
    • Ilkayeva O 3
    • Newgard CB 3
    (2 authors)
  • 4. Faculty of Forestry and Wildlife Management, Hedmark University College, 2418 Elverum, Norway; Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, 90183 Umeå, Sweden.
      Authors
    • Arnemo JM 4
    (1 author)
  • 5. Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, 90183 Umeå, Sweden.
      Authors
    • Kindberg J 5
    (1 author)
    • Show all (7)

ORCIDs linked to this article

Cell Reports, 04 Feb 2016, 14(7):1655-1661
https://doi.org/10.1016/j.celrep.2016.01.026 PMID: 26854221 

A comment on this article appears in "Bears Arouse Interest in Microbiota's Role in Health." Trends Microbiol. 2016 Apr;24(4):245-6.

Abstract 

Hibernation is an adaptation that helps many animals to conserve energy during food shortage in winter. Brown bears double their fat depots during summer and use these stored lipids during hibernation. Although bears seasonally become obese, they remain metabolically healthy. We analyzed the microbiota of free-ranging brown bears during their active phase and hibernation. Compared to the active phase, hibernation microbiota had reduced diversity, reduced levels of Firmicutes and Actinobacteria, and increased levels of Bacteroidetes. Several metabolites involved in lipid metabolism, including triglycerides, cholesterol, and bile acids, were also affected by hibernation. Transplantation of the bear microbiota from summer and winter to germ-free mice transferred some of the seasonal metabolic features and demonstrated that the summer microbiota promoted adiposity without impairing glucose tolerance, suggesting that seasonal variation in the microbiota may contribute to host energy metabolism in the hibernating brown bear.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.celrep.2016.01.026

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S2211124716000474/pdfUnpaywall

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Funding 

Funders who supported this work.

European Research Council (1)

IngaBritt och Arne Lundbergs Forskningsstiftelse

    Knut och Alice Wallenbergs Stiftelse

      Lundbeck Foundation (2)

      Lundbeckfonden (1)

      Miljødirektoratet

        NNF Center for Basic Metabolic Research (1)

        Naturvårdsverket

          Norges Forskningsråd

            Novo Nordisk Fonden (1)

            Sahlgrenska Universitetssjukhuset

              Stiftelsen för Strategisk Forskning

                Svenska Jägareförbundet

                  Torsten Söderbergs Stiftelse

                    Vetenskapsrådet

                      Världsnaturfonden WWF

                        Västra Götalandsregionen