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The effect of host genetics on the gut microbiome.

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Affiliations

  • 1. University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
      Authors
    • Bonder MJ 1
    • Kurilshikov A 1
    • Tigchelaar EF 1, 2
    • Deelen P 1
    • Zhernakova DV 1
    • Jankipersadsing SA 1, 8
    • Cenit MC 1
    • Swertz MA 1
    • Li Y 1
    • Kumar V 1
    • Franke L 1
    • Wijmenga C 1
    • Fu J 1, 8
    • Zhernakova A 1, 2
    (14 authors)
  • 2. Top Institute Food and Nutrition, Wageningen, the Netherlands.
      Authors
    • Tigchelaar EF 1, 2
    • Mujagic Z 2, 6
    • Zhernakova A 1, 2
    (3 authors)
  • 3. University of Groningen, University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, the Netherlands.
      Authors
    • Imhann F 3
    • Vila AV 3
    • Weersma RK 3
    (3 authors)
  • 4. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
      Authors
    • Vatanen T 4
    • Schirmer M 4
    • Xavier RJ 4
    (3 authors)
  • 5. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
      Authors
    • Smeekens SP 5
    • Jaeger M 5
    • Oosting M 5
    • Joosten L 5
    • Netea MG 5
    (5 authors)
    • Show all (8)

ORCIDs linked to this article

Show all (16)

Nature Genetics, 03 Oct 2016, 48(11):1407-1412
https://doi.org/10.1038/ng.3663 PMID: 27694959 

A comment on this article appears in ""Nature versus Nurture" and the indigenous microbiome." J Public Health Emerg. 2017 Mar;1:.

Abstract 

The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10-8. Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10-6. Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F-CD207 at 2p13.3 and CLEC4A-FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus (P = 3.45 × 10-8) and provide evidence of a gene-diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host-microbe interactions to gain better insight into human health.

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Read article at publisher's site: https://doi.org/10.1038/ng.3663

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