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Association of host genome with intestinal microbial composition in a large healthy cohort.

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  • 1. Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
      Authors
    • Turpin W 1
    • Silverberg MS 1, 2
    • Kevans D 1
    • Smith MI 1, 2
    • Croitoru K 1, 2
    (5 authors)
  • 2. Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
      Authors
    • Espin-Garcia O 2, 3
    • Silverberg MS 1, 2
    • Smith MI 1, 2
    • Croitoru K 1, 2
    (4 authors)
  • 3. Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
      Authors
    • Espin-Garcia O 2, 3
    • Xu W 3
    • Xu L 3
    • Shestopaloff K 3
    • Paterson AD 3
    (5 authors)
  • 4. Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
      Authors
    • Guttman DS 4
    (1 author)
  • 5. Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
      Authors
    • Griffiths A 5
    (1 author)
    • Show all (8)

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Nature Genetics, 03 Oct 2016, 48(11):1413-1417
https://doi.org/10.1038/ng.3693 PMID: 27694960 

Abstract 

Intestinal microbiota is known to be important in health and disease. Its composition is influenced by both environmental and host factors. Few large-scale studies have evaluated the association between host genetic variation and the composition of microbiota. We recruited a cohort of 1,561 healthy individuals, of whom 270 belong in 123 families, and found that almost one-third of fecal bacterial taxa were heritable. In addition, we identified 58 SNPs associated with the relative abundance of 33 taxa in 1,098 discovery subjects. Among these, four loci were replicated in a second cohort of 463 subjects: rs62171178 (nearest gene UBR3) associated with Rikenellaceae, rs1394174 (CNTN6) associated with Faecalibacterium, rs59846192 (DMRTB1) associated with Lachnospira, and rs28473221 (SALL3) associated with Eubacterium. After correction for multiple testing, 6 of the 58 associations remained significant, one of which replicated. These results identify associations between specific genetic variants and the gut microbiome.

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