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The human beta-globin gene contains a downstream developmental specific enhancer.

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Nucleic Acids Research, 01 Jul 1987, 15(14):5739-5747
https://doi.org/10.1093/nar/15.14.5739 PMID: 3039464 PMCID: PMC306019

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Abstract 

The human beta-globin gene is part of a multigene family and is expressed specifically in adult human erythroid tissue (for review, 1). When the human beta-globin is introduced into fertilized mouse eggs, it is first activated in foetal liver and remains expressed in adult erythroid tissues. It therefore mimicks the pattern of expression of its murine counterpart. It has previously been shown in tissue culture and transgenic mice that sequences downstream from the beta-globin promoter are involved in this regulation. We now show that at least part of these sequences are located 0.5-1.2kb downstream from the poly A addition site and constitute a transcriptional enhancer element that is erythroid and developmental specific.

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Nucleic Acids Res. 1987 Jul 24; 15(14): 5739–5747.
PMCID: PMC306019
PMID: 3039464

The human beta-globin gene contains a downstream developmental specific enhancer.

G Kollias, J Hurst, E deBoer, and F Grosveld
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Abstract

The human beta-globin gene is part of a multigene family and is expressed specifically in adult human erythroid tissue (for review, 1). When the human beta-globin is introduced into fertilized mouse eggs, it is first activated in foetal liver and remains expressed in adult erythroid tissues. It therefore mimicks the pattern of expression of its murine counterpart. It has previously been shown in tissue culture and transgenic mice that sequences downstream from the beta-globin promoter are involved in this regulation. We now show that at least part of these sequences are located 0.5-1.2kb downstream from the poly A addition site and constitute a transcriptional enhancer element that is erythroid and developmental specific.

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Selected References

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