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Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs.

The Journal of Clinical Investigation, 01 Oct 1981, 68(4):1106-1107
https://doi.org/10.1172/jci110335 PMID: 7287903 PMCID: PMC370900

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Abstract 

To determine whether gastric inhibitory polypeptide (GIP) promotes the clearance of chylomicron triglycerides (TG) from the circulation in dogs, chyle collected from donor dogs via a thoracic duct fistula was infused at a rate of 2 ml/min i.v. into normal recipient dogs during an infusion of either porcine GIP (1 microgram/kg per h) or saline as a control. In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 +/- 4 mg/dl vs. 82 +/- 18 mg/dl (P less than 0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood. The results suggest that GIP may play a physiologic role in the disposition of ingested fat.

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Logo of jcinvestThe Journal of Clinical Investigation
J Clin Invest. 1981 Oct; 68(4): 1106–1107.
PMCID: PMC370900
PMID: 7287903

Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs.

T Wasada, K McCorkle, V Harris, K Kawai, B Howard, and R H Unger
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Abstract

To determine whether gastric inhibitory polypeptide (GIP) promotes the clearance of chylomicron triglycerides (TG) from the circulation in dogs, chyle collected from donor dogs via a thoracic duct fistula was infused at a rate of 2 ml/min i.v. into normal recipient dogs during an infusion of either porcine GIP (1 microgram/kg per h) or saline as a control. In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 +/- 4 mg/dl vs. 82 +/- 18 mg/dl (P less than 0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood. The results suggest that GIP may play a physiologic role in the disposition of ingested fat.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Eckel RH, Fujimoto WY, Brunzell JD. Gastric inhibitory polypeptide enhanced lipoprotein lipase activity in cultured preadipocytes. Diabetes. 1979 Dec;28(12):1141–1142. [Abstract] [Google Scholar]
  • Dupre J, Ross SA, Watson D, Brown JC. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab. 1973 Nov;37(5):826–828. [Abstract] [Google Scholar]
  • Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973 May;19(5):476–482. [Abstract] [Google Scholar]
  • YALOW RS, BERSON SA. Immunoassay of endogenous plasma insulin in man. J Clin Invest. 1960 Jul;39:1157–1175. [Europe PMC free article] [Abstract] [Google Scholar]
  • Harris V, Conlon JM, Srikant CB, McCorkle K, Schusdziarra V, Ipp E, Unger RH. Measurements of somatostatin-like immunoreactivity in plasma. Clin Chim Acta. 1978 Jul 15;87(2):275–283. [Abstract] [Google Scholar]
  • Falko JM, Crockett SE, Cataland S, Mazzaferri EL. Gastric inhibitory polypeptide (GIP) stimulated by fat ingestion in man. J Clin Endocrinol Metab. 1975 Aug;41(2):260–265. [Abstract] [Google Scholar]
  • Pederson RA, Schubert HE, Brown JC. Gastric inhibitory polypeptide. Its physiologic release and insulinotropic action in the dog. Diabetes. 1975 Dec;24(12):1050–1056. [Abstract] [Google Scholar]
  • Rouiller D, Schusdziarra V, Harris V, Unger RH. Release of pancreatic and gastric somatostatin-like immunoreactivity in response to the octapeptide of cholecystokinin, secretin gastric inhibitory polypeptide, and gastrin-17 in dogs. Endocrinology. 1980 Aug;107(2):524–529. [Abstract] [Google Scholar]
  • Böttger I, Dobbs R, Faloona GR, Unger RH. The effects of triglyceride absorption upon glucagon, insulin, and gut glucagon-like immunoreactivity. J Clin Invest. 1973 Oct;52(10):2532–2541. [Europe PMC free article] [Abstract] [Google Scholar]
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NIADDK NIH HHS (2)