BBC Russian
Svoboda | Graniru | BBC Russia | Golosameriki | Facebook

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.

Author information

Affiliations

  • 1. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
      Authors
    • Borén T 1
    (1 author)

Science, 01 Dec 1993, 262(5141):1892-1895
https://doi.org/10.1126/science.8018146 PMID: 8018146 

A comment on this article appears in "Blood type and the risk of gastric disease." Science. 1994 Jun 3;264(5164):1386-8. A comment on this article appears in "New bind for ulcer bacterium." Science. 1993 Dec 17;262(5141):1817.

Abstract 

Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. The Lewis(b) (Le(b)) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Leb antigen or antibodies to the Leb antigen inhibited bacterial binding. Gastric tissue lacking Leb expression did not bind H. pylori. Bacteria did not bind to Leb antigen substituted with a terminal GalNAc alpha 1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.

Full text links 

Read article at publisher's site: https://doi.org/10.1126/science.8018146

Citations & impact 

Impact metrics

628
Citations
Jump to Citations
6
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/1430299
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/1430299

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1126/science.8018146

Supporting
Mentioning
Contrasting
16
718
1

Article citations

Go to all (628) article citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

FIC NIH HHS (1)