| PMC full text: | Published online 2023 Dec 1. doi: 10.17305/bb.2023.9244
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Table 3
Association of ABO polymorphisms with ACS accordance to the inheritance models
| Polymorphic site (rsID-number) | Model | Genotype | ACS patient, n ═ 611 (n[%]) | Controls, n ═ 676 (n[%]) | OR (95%CI) | P-value |
|---|---|---|---|---|---|---|
| rs8176746 | Co-dominant | GG GT TT | 540 (0.884) 69 (0.113) 2 (0.003) | 555 (0.821) 112 (0.166) 9 (0.013) | 0.17 (0.03–0.97) | 0.0004 |
| Dominant | GG GT + TT | 540 (0.884) 71 (0.116) | 555 (0.821) 121 (0.179) | 0.49 (0.34–0.72) | 0.0002 | |
| Recessive | GG + GT TT | 609 (0.997) 2 (0.003) | 667 (0.987) 9 (0.013) | 0.19 (0.03–1.06) | 0.039 | |
| Over-dominant | GG + TT GT | 542 (0.887) 69 (0.113) | 564 (0.834) 112 (0.166) | 0.53 (0.36–0.77) | 0.0009 | |
| Additive | – | – | – | 0.50 (0.35–0.71) | 0.0001 | |
| rs8176740 | Co-dominant | TT TA AA | 180 (0.294) 296 (0.484) 135 (0.221) | 167 (0.247) 332 (0.492) 176 (0.261) | 0.69 (0.49–1.00) | 0.041 |
| Dominant | TT TA + AA | 180 (0.295) 431 (0.705) | 167 (0.247) 508 (0.753) | 0.71 (0.53–0.95) | 0.022 | |
| Recessive | TT + TA AA | 476 (0.779) 135 (0.221) | 499 (0.739) 176 (0.261) | 0.90 (0.65–1.21) | 0.479 | |
| Over-dominant | TT + AA TA | 315 (0.515) 296 (0.485) | 343 (0.508) 332 (0.492) | 0.83 (0.64–1.07) | 0.149 | |
| Additive | – | – | – | 0.84 (0.70–1.00) | 0.039 | |
| rs579459 | Co-dominant | TT TC CC | 438 (0.717) 157 (0.257) 16 (0.026) | 445 (0.659) 200 (0.296) 30 (0.044) | 0.75 (0.53–0.97) | 0.081 |
| Dominant | TT TC + CC | 438 (0.717) 173 (0.283) | 445 (0.659) 230 (0.341) | 0.72 (0.54–0.96) | 0.025 | |
| Recessive | TT + TC CC | 595 (0.974) 16 (0.026) | 645 (0.956) 30 (0.044) | 0.82 (0.40–1.71) | 0.599 | |
| Over-dominant | TT + CC TC | 454 (0.743) 157 (0.257) | 475 (0.704) 200 (0.296) | 0.73 (0.54–0.98) | 0.035 | |
| Additive | – | – | – | 0.77 (0.60–0.99) | 0.037 |
The P-values were calculated by the logistic regression analysis, and ORs were adjusted for gender, age, blood pressure, BMI, glucose, total cholesterol, HDL-C, triglycerides, and smoking habit. Bold: P < 0.05; ACS: Acute coronary syndrome; OR: Odds ratio; CI: Confidence interval.