| PMC full text: | Science. Author manuscript; available in PMC 2009 Feb 22. Published in final edited form as: Science. 2007 May 11; 316(5826): 889–894. Published online 2007 Apr 12. doi: 10.1126/science.1141634 |
Table 2
Association of BMI (corrected for sex) and birth weight (corrected for sex and gestational age) with rs9939609 genotypes in children. P values represent the change in log BMI per A allele. BMI presented as geometric means and back-transformed 95% confidence intervals.
| Cohort | Age (years) | Males (%) | N | Mean trait value (95% CI) by genotype | P | ||
|---|---|---|---|---|---|---|---|
| TT | AT | AA | |||||
| Children* | |||||||
| ALSPAC | 7 | 51 | 5969 | 16.00 (15.92, 16.07) | 16.11 (16.04, 16.18) | 16.31 (16.19, 16.43) | 3 × 10−5 |
| 8 | 50 | 4871 | 16.80 (16.70, 16.90) | 17.01 (16.92, 17.09) | 17.29 (17.14, 17.45) | 1 × 10−7 | |
| 9 | 50 | 5459 | 17.20 (17.08, 17.31) | 17.53 (17.43, 17.63) | 17.86 (17.69, 18.04) | 5 × 10−11 | |
| 10 | 50 | 5273 | 17.66 (17.54, 17.79) | 18.05 (17.94, 18.17) | 18.37 (18.18, 18.57) | 1 × 10−10 | |
| 11 | 49 | 5010 | 18.46 (18.32, 18.61) | 18.82 (18.70, 18.94) | 19.20 (18.98, 19.42) | 7 × 10−9 | |
| NFBC1966 (age 14) | 14 | 47 | 4203 | 19.14 (19.02, 19.26) | 19.25 (19.14, 19.36) | 19.38 (19.19, 19.57) | 0.04 |
| Birth† | |||||||
| ALSPAC | 0 | 51 | 7477 | 3438 (3422, 3455) | 3452 (3437, 3466) | 3454 (3429, 3480) | 0.21 |
| NFBC1966 | 0 | 47 | 4320 | 3523 (3501, 3546) | 3538 (3518, 3558) | 3536 (3501, 3571) | 0.42 |
*ALSPAC children are offspring of the participants included in the adult study (Table 1), and data are shown at five available ages. NFBC1966 children are the same participants as those in the adult study (Table 1).
†ALSPAC birth data are for the same participants as those in the children study. NFBC1966 birth data are for the same participants as those in the children and adult studies. Non-singleton births and individuals born at gestation <36 weeks were excluded from the birth-weight analysis.