Mendelian randomization in health research: Using appropriate genetic variants and avoiding biased estimates

doi:10.1016/j.ehb.2013.12.002

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PMC full text:

Econ Hum Biol. 2014 Mar; 13(100): 99–106.

doi: 10.1016/j.ehb.2013.12.002

Table 2

Results of data simulation showing unbiased estimate from two-stage least-squares regression in the presence of confounding.

Model	Beta (95% CI)^a
Y on X (linear regression)	0.26 (0.25, 0.28)
Y on X (two stage least squares)	−0.29 (−0.37, −0.21)

^aTrue value of beta from simulation is −0.3.