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Impact of malaria on genetic polymorphism and genetic diseases in Africans and African Americans.

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Affiliations

  • 1. Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
      Authors
    • Miller LH 1
    (1 author)

Proceedings of the National Academy of Sciences of the United States of America, 01 Mar 1994, 91(7):2415-2419
https://doi.org/10.1073/pnas.91.7.2415 PMID: 8146132 PMCID: PMC43381

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Abstract 

The high mortality from malaria in sub-Sahara Africa selected multiple genes that give the population a selective advantage. Identification of the genetic basis for resistance may suggest unusual approaches to development of malarial vaccines and antimalarial drugs. Some of these genes may be deleterious, although of selective advantage within the African setting, and need to be identified for counseling for disease prevention.

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Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7): 2415–2419.
PMCID: PMC43381
PMID: 8146132

Impact of malaria on genetic polymorphism and genetic diseases in Africans and African Americans.

L H Miller
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Abstract

The high mortality from malaria in sub-Sahara Africa selected multiple genes that give the population a selective advantage. Identification of the genetic basis for resistance may suggest unusual approaches to development of malarial vaccines and antimalarial drugs. Some of these genes may be deleterious, although of selective advantage within the African setting, and need to be identified for counseling for disease prevention.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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