Autophagic lysosome reformation (ALR) is the terminal step of autophagy and is essential for maintaining lysosome homeostasis during autophagy. During ALR, tubules are extruded from autolysosomes, and small vesicles named proto-lysosomes, which are composed of lysosomal membrane components, are generated from these tubules. Eventually, proto-lysosomes mature into functional lysosomes. In this review, we will summarize recent progress in understanding the regulation, mechanisms and physiological functions of ALR.
Keywords: KIF5B; autophagic lysosome reformation (ALR); autophagy; clathrin; in vitro reconstitution; membrane deformation; phospholipid.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.