Diklofenamid
Diklofenamid (dihlorfenamid) je sulfonamid i inhibitor karbonske anhidraze iz meta-disulfamoilbenzenske klase.[6][7]
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(IUPAC) ime | |||
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4,5-dihlorobenzen-1,3-disulfonamid | |||
Klinički podaci | |||
AHFS/Drugs.com | Internacionalno ime leka | ||
MedlinePlus | a601233 | ||
Identifikatori | |||
CAS broj | 120-97-8 | ||
ATC kod | S01EC02 | ||
PubChem[1][2] | 3038 | ||
DrugBank | DB01144 | ||
ChemSpider[3] | 2930 | ||
UNII | VVJ6673MHY ![]() | ||
KEGG[4] | D00518 ![]() | ||
ChEBI | CHEBI:101085 ![]() | ||
ChEMBL[5] | CHEMBL17 ![]() | ||
Hemijski podaci | |||
Formula | C6H6Cl2N2O4S2 | ||
Mol. masa | 305,16 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakokinetički podaci | |||
Vezivanje za proteine plazme | 55% | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Upotreba
urediDiklofenamid se često koristi za tretiranje epolepsije.[8]
References
uredi- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Tawil R, McDermott M, Brown R, Shapiro B, Ptacek L, McManis P, Dalakas M, Spector S, Mendell J, Hahn A, Griggs R (2000). „Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis.”. Ann Neurol 47 (1): 46–53. DOI:10.1002/1531-8249(200001)47:1<46::AID-ANA9>3.0.CO;2-H. PMID 10632100.
- ↑ Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S (1991). „[Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences]”. Eisei Shikenjo Hokoku 109 (109): 148–50. PMID 1364383.
- ↑ Rucquoy M.; Sorel L.. „Diclofenamide in the treatment of therapy-resistant epilepsy.”. PubMed. Pristupljeno 13. 5. 2013.