Welcome to the Carbohydrate-Active enZYmes Database
The May 2024 update of CAZy
After an amazing CBM15 conference in Ghent (Belgia), this month, we officialized two novel CBM families, CBM102 and CBM103, both with laminarin-binding members described by Zühlke and coworkers.
We also implemented the division into subfamilies of the GH123 family.
This was done according to the initial presentation of the two first subfamilies last year by Moreno Prieto and coworkers, recently completed by two additional subfamilies by Sumida and coworkers.
However, please note that their group numbering do not correspond to the subfamily numbering : group 1 is GH123_4 ; group 2 is GH123_5 ; group 3 is GH123_3 ; group 4 is GH123_2 and group GH123 is GH123_1).
Most of these subfamilies (apart GH123_1) were previously classified as GH_nc given their weak signals of homology to characterized GH123(_1) members.
CAZy now offers a platform facility that provides either automatic annotation or human curation services for your data.
The fully automatic annotation is to provide users with high quality and most up-to-date results.
However, since automatic annotation is never error-free, and while we are working at constantly improving our pipeline, a "human curation" service also exists for the highest-quality analyses.
Because human curation requires expertise and time, and because such resources are limited, a query for human curation will have to be validated by the CAZy scientific committee.
If you are interested, please visit CAZy bioinformatics web page and contact : [email protected].
The CAZy database describes the families of structurally-related catalytic and carbohydrate-binding modules (or functional domains) of enzymes that degrade, modify, or create glycosidic bonds.
Online since 1998, CAZy is a specialist database dedicated to the display and analysis of genomic, structural and biochemical information on Carbohydrate-Active Enzymes (CAZymes).
CAZy data are accessible either by browsing sequence-based families or by browsing the content of genomes in carbohydrate-active enzymes. New genomes are added regularly shortly after they appear in the daily releases of GenBank.
New families are created based on published evidence for the activity of at least one member of the family and all families are regularly updated, both in content and in description.
An original aspect of the CAZy database is its attempt to cover all carbohydrate-active enzymes across organisms and across subfields of glycosciences. Please let us know if some families have escaped our attention, we will be happy to add them !
For a more extensive encyclopedic resource on the particular features of carbohydrate active enzymes, please visit CAZypedia, a web site driven by the scientific community that studies these enzymes.
PULDB is a database of Polysaccharide Utilization Loci (PULs) in Bacteroidetes. PULDB displays information on experimentally determined and predicted PULs for a number of Bacteroidetes genomes.
A new reference for the CAZy database : We summarized the recent changes in the CAZy database, and evolution during the last eight years in an article published the Nucleic Acids Research (Database Issue), with a specific focus on functional annotations.
Read the full paper.
Associated Modules currently covered
Carbohydrate-active enzymes often display a modular structure with non-catalytic modules appended to the enzymes above
Carbohydrate-Binding Modules (CBMs) : adhesion to carbohydrates
Genome analysis by CAZy
Family distribution and/or protein listings of the carbohydrate-active enzymes and associated proteins identified in genomes
Genomes by Kingdom :